Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium
Identifieur interne : 001E16 ( Pmc/Corpus ); précédent : 001E15; suivant : 001E17Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium
Auteurs : Silvia De Sanjose ; Yolanda Benavente ; Claire M. Vajdic ; Eric A. Engels ; Lindsay M. Morton ; Paige M. Bracci ; John J. Spinelli ; Tongzhang Zheng ; Yawei Zhang ; Silvia Franceschi ; Renato Talamini ; Elizabeth A. Holly ; Andrew E. Grulich ; James R. Cerhan ; Patricia Hartge ; Wendy Cozen ; Paolo Boffetta ; Paul Brennan ; Marc Maynadié ; Pierluigi Cocco ; Ramon Bosch ; Lenka Foretova ; Anthony Staines ; Nikolaus Becker ; Alexandra NietersSource :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-3565 ] ; 2008.
Abstract
Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin’s lymphoma (NHL) subtypes after HCV infection.
The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded.
HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40–2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44–4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68–2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14–5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65–1.60).
These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).
Url:
DOI: 10.1016/j.cgh.2008.02.011
PubMed: 18387498
PubMed Central: 3962672
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Vajdic</name><affiliation><nlm:aff id="A2">National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Engels, Eric A" sort="Engels, Eric A" uniqKey="Engels E" first="Eric A." last="Engels">Eric A. Engels</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</nlm:aff></affiliation></author><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</nlm:aff></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</nlm:aff></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name><affiliation><nlm:aff id="A5">Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, Canada</nlm:aff></affiliation></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name><affiliation><nlm:aff id="A7">Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Talamini, Renato" sort="Talamini, Renato" uniqKey="Talamini R" first="Renato" last="Talamini">Renato Talamini</name><affiliation><nlm:aff id="A8">Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, Italy</nlm:aff></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</nlm:aff></affiliation></author><author><name sortKey="Grulich, Andrew E" sort="Grulich, Andrew E" uniqKey="Grulich A" first="Andrew E." last="Grulich">Andrew E. Grulich</name><affiliation><nlm:aff id="A2">National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R." last="Cerhan">James R. Cerhan</name><affiliation><nlm:aff id="A9">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</nlm:aff></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation><nlm:aff id="A10">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation><nlm:aff id="A7">Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A7">Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name><affiliation><nlm:aff id="A11">Registre des Hemopathies Malignes de Cote d’Or, Faculte de Medecine de Dijon, Dijon, France</nlm:aff></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:aff id="A12">Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ramon" sort="Bosch, Ramon" uniqKey="Bosch R" first="Ramon" last="Bosch">Ramon Bosch</name><affiliation><nlm:aff id="A13">Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain</nlm:aff></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:aff id="A14">Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name><affiliation><nlm:aff id="A15">Department of Public Health, Public Health University College, Dublin, Irelandy</nlm:aff></affiliation></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><affiliation><nlm:aff id="A16">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation><nlm:aff id="A16">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18387498</idno><idno type="pmc">3962672</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962672</idno><idno type="RBID">PMC:3962672</idno><idno type="doi">10.1016/j.cgh.2008.02.011</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001E16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium</title><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:aff id="A1">Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d’Investigació Biomèdica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name><affiliation><nlm:aff id="A1">Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d’Investigació Biomèdica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M." last="Vajdic">Claire M. Vajdic</name><affiliation><nlm:aff id="A2">National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Engels, Eric A" sort="Engels, Eric A" uniqKey="Engels E" first="Eric A." last="Engels">Eric A. Engels</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</nlm:aff></affiliation></author><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M." last="Morton">Lindsay M. Morton</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</nlm:aff></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M." last="Bracci">Paige M. Bracci</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</nlm:aff></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J." last="Spinelli">John J. Spinelli</name><affiliation><nlm:aff id="A5">Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, Canada</nlm:aff></affiliation></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation><nlm:aff id="A6">Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut</nlm:aff></affiliation></author><author><name sortKey="Franceschi, Silvia" sort="Franceschi, Silvia" uniqKey="Franceschi S" first="Silvia" last="Franceschi">Silvia Franceschi</name><affiliation><nlm:aff id="A7">Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Talamini, Renato" sort="Talamini, Renato" uniqKey="Talamini R" first="Renato" last="Talamini">Renato Talamini</name><affiliation><nlm:aff id="A8">Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, Italy</nlm:aff></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A." last="Holly">Elizabeth A. Holly</name><affiliation><nlm:aff id="A4">Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</nlm:aff></affiliation></author><author><name sortKey="Grulich, Andrew E" sort="Grulich, Andrew E" uniqKey="Grulich A" first="Andrew E." last="Grulich">Andrew E. Grulich</name><affiliation><nlm:aff id="A2">National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia</nlm:aff></affiliation></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R." last="Cerhan">James R. Cerhan</name><affiliation><nlm:aff id="A9">Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation><nlm:aff id="A3">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</nlm:aff></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation><nlm:aff id="A10">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation><nlm:aff id="A7">Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A7">Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadié">Marc Maynadié</name><affiliation><nlm:aff id="A11">Registre des Hemopathies Malignes de Cote d’Or, Faculte de Medecine de Dijon, Dijon, France</nlm:aff></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:aff id="A12">Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ramon" sort="Bosch, Ramon" uniqKey="Bosch R" first="Ramon" last="Bosch">Ramon Bosch</name><affiliation><nlm:aff id="A13">Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain</nlm:aff></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:aff id="A14">Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name><affiliation><nlm:aff id="A15">Department of Public Health, Public Health University College, Dublin, Irelandy</nlm:aff></affiliation></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><affiliation><nlm:aff id="A16">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation><nlm:aff id="A16">Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</title><idno type="ISSN">1542-3565</idno><idno type="eISSN">1542-7714</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background & Aims</title><p id="P1">Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin’s lymphoma (NHL) subtypes after HCV infection.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded.</p></sec><sec id="S3"><title>Results</title><p id="P3">HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40–2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44–4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68–2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14–5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65–1.60).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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Hepatol.</journal-id><journal-title-group><journal-title>Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</journal-title></journal-title-group><issn pub-type="ppub">1542-3565</issn><issn pub-type="epub">1542-7714</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18387498</article-id><article-id pub-id-type="pmc">3962672</article-id><article-id pub-id-type="doi">10.1016/j.cgh.2008.02.011</article-id><article-id pub-id-type="manuscript">NIHMS557278</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Hepatitis C and Non-Hodgkin Lymphoma Among 4784 Cases and 6269 Controls From the International Lymphoma Epidemiology Consortium</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>de Sanjose</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Benavente</surname><given-names>Yolanda</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Vajdic</surname><given-names>Claire M.</given-names></name><xref ref-type="aff" rid="A2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Engels</surname><given-names>Eric A.</given-names></name><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Morton</surname><given-names>Lindsay M.</given-names></name><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Bracci</surname><given-names>Paige M.</given-names></name><xref ref-type="aff" rid="A4">_</xref></contrib><contrib contrib-type="author"><name><surname>Spinelli</surname><given-names>John J.</given-names></name><xref ref-type="aff" rid="A5">¶</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Tongzhang</given-names></name><xref ref-type="aff" rid="A6">#</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Yawei</given-names></name><xref ref-type="aff" rid="A6">#</xref></contrib><contrib contrib-type="author"><name><surname>Franceschi</surname><given-names>Silvia</given-names></name><xref ref-type="aff" rid="A7">**</xref></contrib><contrib contrib-type="author"><name><surname>Talamini</surname><given-names>Renato</given-names></name><xref ref-type="aff" rid="A8">‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Holly</surname><given-names>Elizabeth A.</given-names></name><xref ref-type="aff" rid="A4">_</xref></contrib><contrib contrib-type="author"><name><surname>Grulich</surname><given-names>Andrew E.</given-names></name><xref ref-type="aff" rid="A2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Cerhan</surname><given-names>James R.</given-names></name><xref ref-type="aff" rid="A9">§§</xref></contrib><contrib contrib-type="author"><name><surname>Hartge</surname><given-names>Patricia</given-names></name><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Cozen</surname><given-names>Wendy</given-names></name><xref ref-type="aff" rid="A10">_ _</xref></contrib><contrib contrib-type="author"><name><surname>Boffetta</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A7">**</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A7">**</xref></contrib><contrib contrib-type="author"><name><surname>Maynadié</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="A11">¶¶</xref></contrib><contrib contrib-type="author"><name><surname>Cocco</surname><given-names>Pierluigi</given-names></name><xref ref-type="aff" rid="A12">##</xref></contrib><contrib contrib-type="author"><name><surname>Bosch</surname><given-names>Ramon</given-names></name><xref ref-type="aff" rid="A13">***</xref></contrib><contrib contrib-type="author"><name><surname>Foretova</surname><given-names>Lenka</given-names></name><xref ref-type="aff" rid="A14">‡‡‡</xref></contrib><contrib contrib-type="author"><name><surname>Staines</surname><given-names>Anthony</given-names></name><xref ref-type="aff" rid="A15">§§§</xref></contrib><contrib contrib-type="author"><name><surname>Becker</surname><given-names>Nikolaus</given-names></name><xref ref-type="aff" rid="A16">_ __</xref></contrib><contrib contrib-type="author"><name><surname>Nieters</surname><given-names>Alexandra</given-names></name><xref ref-type="aff" rid="A16">_ __</xref></contrib></contrib-group><aff id="A1"><label>*</label>Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d’Investigació Biomèdica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain</aff><aff id="A2"><label>‡</label>National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia</aff><aff id="A3"><label>§</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland</aff><aff id="A4"><label>_</label>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</aff><aff id="A5"><label>¶</label>Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, Canada</aff><aff id="A6"><label>#</label>Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut</aff><aff id="A7"><label>**</label>Genetic Epidemiology Group, International Agency for Research in Cancer, Lyon, France</aff><aff id="A8"><label>‡‡</label>Epidemiology and Biostatistics Unit, Aviano Cancer Centre, Aviano, Italy</aff><aff id="A9"><label>§§</label>Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota</aff><aff id="A10"><label>_ _</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</aff><aff id="A11"><label>¶¶</label>Registre des Hemopathies Malignes de Cote d’Or, Faculte de Medecine de Dijon, Dijon, France</aff><aff id="A12"><label>##</label>Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy</aff><aff id="A13"><label>***</label>Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain</aff><aff id="A14"><label>‡‡‡</label>Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</aff><aff id="A15"><label>§§§</label>Department of Public Health, Public Health University College, Dublin, Irelandy</aff><aff id="A16"><label>_ __</label>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany</aff><author-notes><corresp id="cor1"><bold>Corresponding Author</bold>: Silvia de Sanjosé, MD, PhD, Unit of Infections and Cancer, Catalan Institut of Oncology, Institut d’Investigació Biomèdica de Bellvitge, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Gran Via km 2.7, 08907 L’Hospitalet de Llobregat, <email>iconcologia.net</email>; fax: (34) 93 2607787. Barcelona, Spain. <email>s.sanjose@iconcologia.net</email>; fax: (34) 93 2607787</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>3</month><year>2014</year></pub-date><volume>6</volume><issue>4</issue><fpage>451</fpage><lpage>458</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.cgh.2008.02.011</pmc-comment>
<abstract><sec id="S1"><title>Background & Aims</title><p id="P1">Increasing evidence points towards a role of hepatitis C virus (HCV) infection in causing malignant lymphomas. We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin’s lymphoma (NHL) subtypes after HCV infection.</p></sec><sec id="S2"><title>Methods</title><p id="P2">The analysis included 7 member studies from the International Lymphoma Epidemiology Consortium (InterLymph) based in Europe, North America, and Australia. Adult cases of NHL (n = 4784) were diagnosed between 1988 and 2004 and controls (n = 6269) were matched by age, sex, and study center. All studies used third-generation enzyme-linked immunosorbent assays to test for antibodies against HCV in serum samples. Participants who were human immunodeficiency virus positive or were organ-transplant recipients were excluded.</p></sec><sec id="S3"><title>Results</title><p id="P3">HCV infection was detected in 172 NHL cases (3.60%) and in 169 (2.70%) controls (odds ratio [OR], 1.78; 95% confidence interval [CI], 1.40–2.25). In subtype-specific analyses, HCV prevalence was associated with marginal zone lymphoma (OR, 2.47; 95% CI, 1.44–4.23), diffuse large B-cell lymphoma (OR, 2.24; 95% CI, 1.68–2.99), and lymphoplasmacytic lymphoma (OR, 2.57; 95% CI, 1.14–5.79). Notably, risk estimates were not increased for follicular lymphoma (OR, 1.02; 95% CI, 0.65–1.60).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">These results confirm the association between HCV infection and NHL and specific B-NHL subtypes (diffuse large B-cell lymphoma, marginal zone lymphoma, and lymphoplasmacytic lymphoma).</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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