AustralieFrV1, Pmc, Corpus, bibRecord, 001E15

Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis

Identifieur interne : 001E15 ( Pmc/Corpus ); précédent : 001E14; suivant : 001E16

Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis

Auteurs : Azeez Butali ; Julian Little ; Cécile Chevrier ; Sylvian Cordier ; Regine Steegers-Theunissen ; Astanand Jugessur ; Bola Oladugba ; Peter A. Mossey

Source :

Birth defects research. Part A, Clinical and molecular teratology [ 1542-0752 ] ; 2013.

RBID : PMC:3745533

Abstract

Background

This study examines gene-environment interaction (GEI) between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analyticapproach on four studies that used similar methods.

Methods

We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal MTHFR C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non syndromic cleft palate (CP)] and control groups.

Results

There was a reduced risk of CL(P) with maternal folic acid use (p=0.008; OR=0.70, 95% CI: 0.65–0.94) and with supplements containing folic acid (p=0.028, OR=0.80, 95% CI: 0.65–0.94). Maternal smoking increased the risk of both CL(P) (p<10e−3; OR=1.62, 95% CI: 1.35–1.95) and CP (p=0.028; OR=1.38, 95% CI: 1.04–1.83). No significant risk was observed with either maternal or fetal MTHFR C677T genotypes.

Conclusion

This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745533

DOI: 10.1002/bdra.23133
PubMed: 23670871
PubMed Central: 3745533

Links to Exploration step

PMC:3745533

Le document en format XML

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 C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis</title>
<author><name sortKey="Butali, Azeez" sort="Butali, Azeez" uniqKey="Butali A" first="Azeez" last="Butali">Azeez Butali</name>
<affiliation><nlm:aff id="A1">Department of Pediatrics, University of Iowa, U.S.A</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name>
<affiliation><nlm:aff id="A2">Department of Epidemiology and Community Medicine, University of Ottawa, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chevrier, Cecile" sort="Chevrier, Cecile" uniqKey="Chevrier C" first="Cécile" last="Chevrier">Cécile Chevrier</name>
<affiliation><nlm:aff id="A3">Institut National de la Santé et de Recherche Médicale, Rennes, France</nlm:aff>
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<author><name sortKey="Cordier, Sylvian" sort="Cordier, Sylvian" uniqKey="Cordier S" first="Sylvian" last="Cordier">Sylvian Cordier</name>
<affiliation><nlm:aff id="A3">Institut National de la Santé et de Recherche Médicale, Rennes, France</nlm:aff>
</affiliation>
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<author><name sortKey="Steegers Theunissen, Regine" sort="Steegers Theunissen, Regine" uniqKey="Steegers Theunissen R" first="Regine" last="Steegers-Theunissen">Regine Steegers-Theunissen</name>
<affiliation><nlm:aff id="A4">Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands</nlm:aff>
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<affiliation><nlm:aff id="A5">Department of Epidemiology, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff>
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<author><name sortKey="Jugessur, Astanand" sort="Jugessur, Astanand" uniqKey="Jugessur A" first="Astanand" last="Jugessur">Astanand Jugessur</name>
<affiliation><nlm:aff id="A6">Division of Epidemiology, Norwegian Institute of Public Health, N-0403 Oslo, Norway</nlm:aff>
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<affiliation><nlm:aff id="A7">Craniofacial Research, Murdoch Childrens Research Institute, Royal Children's Hospital, 3052 Parkville, Australia</nlm:aff>
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<author><name sortKey="Oladugba, Bola" sort="Oladugba, Bola" uniqKey="Oladugba B" first="Bola" last="Oladugba">Bola Oladugba</name>
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<author><name sortKey="Mossey, Peter A" sort="Mossey, Peter A" uniqKey="Mossey P" first="Peter A." last="Mossey">Peter A. Mossey</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Folic Acid Supplementation Use and the <italic>MTHFR</italic>
 C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis</title>
<author><name sortKey="Butali, Azeez" sort="Butali, Azeez" uniqKey="Butali A" first="Azeez" last="Butali">Azeez Butali</name>
<affiliation><nlm:aff id="A1">Department of Pediatrics, University of Iowa, U.S.A</nlm:aff>
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<author><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name>
<affiliation><nlm:aff id="A2">Department of Epidemiology and Community Medicine, University of Ottawa, Canada</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chevrier, Cecile" sort="Chevrier, Cecile" uniqKey="Chevrier C" first="Cécile" last="Chevrier">Cécile Chevrier</name>
<affiliation><nlm:aff id="A3">Institut National de la Santé et de Recherche Médicale, Rennes, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cordier, Sylvian" sort="Cordier, Sylvian" uniqKey="Cordier S" first="Sylvian" last="Cordier">Sylvian Cordier</name>
<affiliation><nlm:aff id="A3">Institut National de la Santé et de Recherche Médicale, Rennes, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Steegers Theunissen, Regine" sort="Steegers Theunissen, Regine" uniqKey="Steegers Theunissen R" first="Regine" last="Steegers-Theunissen">Regine Steegers-Theunissen</name>
<affiliation><nlm:aff id="A4">Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">Department of Epidemiology, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jugessur, Astanand" sort="Jugessur, Astanand" uniqKey="Jugessur A" first="Astanand" last="Jugessur">Astanand Jugessur</name>
<affiliation><nlm:aff id="A6">Division of Epidemiology, Norwegian Institute of Public Health, N-0403 Oslo, Norway</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A7">Craniofacial Research, Murdoch Childrens Research Institute, Royal Children's Hospital, 3052 Parkville, Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oladugba, Bola" sort="Oladugba, Bola" uniqKey="Oladugba B" first="Bola" last="Oladugba">Bola Oladugba</name>
<affiliation><nlm:aff id="A8">Department of Statistics, University of Nigeria, Nsukka, Nigeria</nlm:aff>
</affiliation>
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<author><name sortKey="Mossey, Peter A" sort="Mossey, Peter A" uniqKey="Mossey P" first="Peter A." last="Mossey">Peter A. Mossey</name>
<affiliation><nlm:aff id="A9">Dundee Dental School and Hospital, University of Dundee, UK</nlm:aff>
</affiliation>
</author>
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<series><title level="j">Birth defects research. Part A, Clinical and molecular teratology</title>
<idno type="ISSN">1542-0752</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">This study examines gene-environment interaction (GEI) between the <italic>MTHFR</italic>
 C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analyticapproach on four studies that used similar methods.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal <italic>MTHFR</italic>
 C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non syndromic cleft palate (CP)] and control groups.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There was a reduced risk of CL(P) with maternal folic acid use (<italic>p</italic>
=0.008; OR=0.70, 95% CI: 0.65–0.94) and with supplements containing folic acid (<italic>p</italic>
=0.028, OR=0.80, 95% CI: 0.65–0.94). Maternal smoking increased the risk of both CL(P) (<italic>p</italic>
<10e−3; OR=1.62, 95% CI: 1.35–1.95) and CP (<italic>p</italic>
=0.028; OR=1.38, 95% CI: 1.04–1.83). No significant risk was observed with either maternal or fetal <italic>MTHFR</italic>
 C677T genotypes.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101155107</journal-id>
<journal-id journal-id-type="pubmed-jr-id">30290</journal-id>
<journal-id journal-id-type="nlm-ta">Birth Defects Res A Clin Mol Teratol</journal-id>
<journal-id journal-id-type="iso-abbrev">Birth Defects Res. Part A Clin. Mol. Teratol.</journal-id>
<journal-title-group><journal-title>Birth defects research. Part A, Clinical and molecular teratology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1542-0752</issn>
<issn pub-type="epub">1542-0760</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23670871</article-id>
<article-id pub-id-type="pmc">3745533</article-id>
<article-id pub-id-type="doi">10.1002/bdra.23133</article-id>
<article-id pub-id-type="manuscript">NIHMS464334</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Folic Acid Supplementation Use and the <italic>MTHFR</italic>
 C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Butali</surname>
<given-names>Azeez</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Little</surname>
<given-names>Julian</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chevrier</surname>
<given-names>Cécile</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cordier</surname>
<given-names>Sylvian</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Steegers-Theunissen</surname>
<given-names>Regine</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jugessur</surname>
<given-names>Astanand</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oladugba</surname>
<given-names>Bola</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mossey</surname>
<given-names>Peter A.</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Pediatrics, University of Iowa, U.S.A</aff>
<aff id="A2"><label>2</label>
Department of Epidemiology and Community Medicine, University of Ottawa, Canada</aff>
<aff id="A3"><label>3</label>
Institut National de la Santé et de Recherche Médicale, Rennes, France</aff>
<aff id="A4"><label>4</label>
Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands</aff>
<aff id="A5"><label>5</label>
Department of Epidemiology, Radboud University Medical Center, Nijmegen, The Netherlands</aff>
<aff id="A6"><label>6</label>
Division of Epidemiology, Norwegian Institute of Public Health, N-0403 Oslo, Norway</aff>
<aff id="A7"><label>7</label>
Craniofacial Research, Murdoch Childrens Research Institute, Royal Children's Hospital, 3052 Parkville, Australia</aff>
<aff id="A8"><label>8</label>
Department of Statistics, University of Nigeria, Nsukka, Nigeria</aff>
<aff id="A9"><label>9</label>
Dundee Dental School and Hospital, University of Dundee, UK</aff>
<author-notes><corresp id="cor1">Corresponding Author: Azeez Butali, Department of Pediatrics, University of Iowa, 500 Newton Road, Iowa City, Iowa. 52242, <email>Azeez-butali@uiowa.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>22</day>
<month>4</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>5</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>8</month>
<year>2014</year>
</pub-date>
<volume>97</volume>
<issue>8</issue>
<elocation-id>10.1002/bdra.23133</elocation-id>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">This study examines gene-environment interaction (GEI) between the <italic>MTHFR</italic>
 C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analyticapproach on four studies that used similar methods.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal <italic>MTHFR</italic>
 C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non syndromic cleft palate (CP)] and control groups.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There was a reduced risk of CL(P) with maternal folic acid use (<italic>p</italic>
=0.008; OR=0.70, 95% CI: 0.65–0.94) and with supplements containing folic acid (<italic>p</italic>
=0.028, OR=0.80, 95% CI: 0.65–0.94). Maternal smoking increased the risk of both CL(P) (<italic>p</italic>
<10e−3; OR=1.62, 95% CI: 1.35–1.95) and CP (<italic>p</italic>
=0.028; OR=1.38, 95% CI: 1.04–1.83). No significant risk was observed with either maternal or fetal <italic>MTHFR</italic>
 C677T genotypes.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.</p>
</sec>
</abstract>
<kwd-group><kwd>Cleft lip and palate</kwd>
<kwd><italic>MTHFR</italic>
</kwd>
<kwd>Folic acid</kwd>
<kwd>Individual patient data</kwd>
<kwd>pooled-analysis</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source>
<award-id>K99 DE022378 || DE</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis

Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki