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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors</title><author><name sortKey="Torchia, Jonathon" sort="Torchia, Jonathon" uniqKey="Torchia J" first="Jonathon" last="Torchia">Jonathon Torchia</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Golbourn, Brian" sort="Golbourn, Brian" uniqKey="Golbourn B" first="Brian" last="Golbourn">Brian Golbourn</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Feng, Shengrui" sort="Feng, Shengrui" uniqKey="Feng S" first="Shengrui" last="Feng">Shengrui Feng</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Ho, King Ching" sort="Ho, King Ching" uniqKey="Ho K" first="King Ching" last="Ho">King Ching Ho</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Sin Chan, Patrick" sort="Sin Chan, Patrick" uniqKey="Sin Chan P" first="Patrick" last="Sin-Chan">Patrick Sin-Chan</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Vasiljevic, Alexandre" sort="Vasiljevic, Alexandre" uniqKey="Vasiljevic A" first="Alexandre" last="Vasiljevic">Alexandre Vasiljevic</name><affiliation><nlm:aff id="A15">Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France</nlm:aff></affiliation></author><author><name sortKey="Norman, Joseph D" sort="Norman, Joseph D" uniqKey="Norman J" first="Joseph D." last="Norman">Joseph D. Norman</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Guilhamon, Paul" sort="Guilhamon, Paul" uniqKey="Guilhamon P" first="Paul" last="Guilhamon">Paul Guilhamon</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Garzia, Livia" sort="Garzia, Livia" uniqKey="Garzia L" first="Livia" last="Garzia">Livia Garzia</name><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Agamez, Natalia R" sort="Agamez, Natalia R" uniqKey="Agamez N" first="Natalia R." last="Agamez">Natalia R. Agamez</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Picard, Daniel" sort="Picard, Daniel" uniqKey="Picard D" first="Daniel" last="Picard">Daniel Picard</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="De Antonellis, Pasqualino" sort="De Antonellis, Pasqualino" uniqKey="De Antonellis P" first="Pasqualino" last="De Antonellis">Pasqualino De Antonellis</name><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Khuong Quang, Dong Anh" sort="Khuong Quang, Dong Anh" uniqKey="Khuong Quang D" first="Dong-Anh" last="Khuong-Quang">Dong-Anh Khuong-Quang</name><affiliation><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Planello, Aline C" sort="Planello, Aline C" uniqKey="Planello A" first="Aline C." last="Planello">Aline C. Planello</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Zeller, Constanze" sort="Zeller, Constanze" uniqKey="Zeller C" first="Constanze" last="Zeller">Constanze Zeller</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Barsyte Lovejoy, Dalia" sort="Barsyte Lovejoy, Dalia" uniqKey="Barsyte Lovejoy D" first="Dalia" last="Barsyte-Lovejoy">Dalia Barsyte-Lovejoy</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Lafay Cousin, Lucie" sort="Lafay Cousin, Lucie" uniqKey="Lafay Cousin L" first="Lucie" last="Lafay-Cousin">Lucie Lafay-Cousin</name><affiliation><nlm:aff id="A20">Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Letourneau, Louis" sort="Letourneau, Louis" uniqKey="Letourneau L" first="Louis" last="Letourneau">Louis Letourneau</name><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Bourgey, Mathieu" sort="Bourgey, Mathieu" uniqKey="Bourgey M" first="Mathieu" last="Bourgey">Mathieu Bourgey</name><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Gendoo, Deena M A" sort="Gendoo, Deena M A" uniqKey="Gendoo D" first="Deena M. A." last="Gendoo">Deena M. A. Gendoo</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Dzamba, Misko" sort="Dzamba, Misko" uniqKey="Dzamba M" first="Misko" last="Dzamba">Misko Dzamba</name><affiliation><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Barszczyk, Mark" sort="Barszczyk, Mark" uniqKey="Barszczyk M" first="Mark" last="Barszczyk">Mark Barszczyk</name><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Medina, Tiago" sort="Medina, Tiago" uniqKey="Medina T" first="Tiago" last="Medina">Tiago Medina</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Riemenschneider, Alexandra N" sort="Riemenschneider, Alexandra N" uniqKey="Riemenschneider A" first="Alexandra N." last="Riemenschneider">Alexandra N. Riemenschneider</name><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Morrissy, A Sorana" sort="Morrissy, A Sorana" uniqKey="Morrissy A" first="A. Sorana" last="Morrissy">A. Sorana Morrissy</name><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Ra, Young Shin" sort="Ra, Young Shin" uniqKey="Ra Y" first="Young-Shin" last="Ra">Young-Shin Ra</name><affiliation><nlm:aff id="A22">Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea</nlm:aff></affiliation></author><author><name sortKey="Ramaswamy, Vijay" sort="Ramaswamy, Vijay" uniqKey="Ramaswamy V" first="Vijay" last="Ramaswamy">Vijay Ramaswamy</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Dunham, Christopher P" sort="Dunham, Christopher P" uniqKey="Dunham C" first="Christopher P." last="Dunham">Christopher P. Dunham</name><affiliation><nlm:aff id="A23">Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff></affiliation></author><author><name sortKey="Yip, Stephen" sort="Yip, Stephen" uniqKey="Yip S" first="Stephen" last="Yip">Stephen Yip</name><affiliation><nlm:aff id="A25">Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Ng, Ho Keung" sort="Ng, Ho Keung" uniqKey="Ng H" first="Ho-Keung" last="Ng">Ho-Keung Ng</name><affiliation><nlm:aff id="A26">Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Lu, Jian Qiang" sort="Lu, Jian Qiang" uniqKey="Lu J" first="Jian-Qiang" last="Lu">Jian-Qiang Lu</name><affiliation><nlm:aff id="A27">Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Mehta, Vivek" sort="Mehta, Vivek" uniqKey="Mehta V" first="Vivek" last="Mehta">Vivek Mehta</name><affiliation><nlm:aff id="A28">Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Steffen" sort="Albrecht, Steffen" uniqKey="Albrecht S" first="Steffen" last="Albrecht">Steffen Albrecht</name><affiliation><nlm:aff id="A18">Department of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="Jose" last="Pimentel">Jose Pimentel</name><affiliation><nlm:aff id="A30">Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff></affiliation></author><author><name sortKey="Chan, Jennifer A" sort="Chan, Jennifer A" uniqKey="Chan J" first="Jennifer A." last="Chan">Jennifer A. Chan</name><affiliation><nlm:aff id="A21">Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada</nlm:aff></affiliation></author><author><name sortKey="Somers, Gino R" sort="Somers, Gino R" uniqKey="Somers G" first="Gino R." last="Somers">Gino R. Somers</name><affiliation><nlm:aff id="A12">Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Faria, Claudia C" sort="Faria, Claudia C" uniqKey="Faria C" first="Claudia C." last="Faria">Claudia C. Faria</name><affiliation><nlm:aff id="A31">Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff></affiliation></author><author><name sortKey="Roque, Lucia" sort="Roque, Lucia" uniqKey="Roque L" first="Lucia" last="Roque">Lucia Roque</name><affiliation><nlm:aff id="A32">Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal</nlm:aff></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation><nlm:aff id="A33">Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA</nlm:aff></affiliation></author><author><name sortKey="Hoffman, Lindsey M" sort="Hoffman, Lindsey M" uniqKey="Hoffman L" first="Lindsey M." last="Hoffman">Lindsey M. Hoffman</name><affiliation><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff></affiliation></author><author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name><affiliation><nlm:aff id="A35">Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Yin" sort="Wang, Yin" uniqKey="Wang Y" first="Yin" last="Wang">Yin Wang</name><affiliation><nlm:aff id="A36">Research Institute of Health Development Strategies, Fudan University, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Choi, Seung Ah" sort="Choi, Seung Ah" uniqKey="Choi S" first="Seung Ah" last="Choi">Seung Ah Choi</name><affiliation><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff></affiliation></author><author><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R." last="Hansford">Jordan R. Hansford</name><affiliation><nlm:aff id="A38">Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia</nlm:aff></affiliation></author><author><name sortKey="Catchpoole, Daniel" sort="Catchpoole, Daniel" uniqKey="Catchpoole D" first="Daniel" last="Catchpoole">Daniel Catchpoole</name><affiliation><nlm:aff id="A39">Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia</nlm:aff></affiliation></author><author><name sortKey="Birks, Diane K" sort="Birks, Diane K" uniqKey="Birks D" first="Diane K." last="Birks">Diane K. Birks</name><affiliation><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff></affiliation></author><author><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K." last="Foreman">Nicholas K. Foreman</name><affiliation><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff></affiliation></author><author><name sortKey="Strother, Doug" sort="Strother, Doug" uniqKey="Strother D" first="Doug" last="Strother">Doug Strother</name><affiliation><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Klekner, Almos" sort="Klekner, Almos" uniqKey="Klekner A" first="Almos" last="Klekner">Almos Klekner</name><affiliation><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff></affiliation></author><author><name sortKey="Bognar, Laszl" sort="Bognar, Laszl" uniqKey="Bognar L" first="Laszl" last="Bognár">Laszl Bognár</name><affiliation><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff></affiliation></author><author><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name><affiliation><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff></affiliation></author><author><name sortKey="Hauser, Peter" sort="Hauser, Peter" uniqKey="Hauser P" first="Péter" last="Hauser">Péter Hauser</name><affiliation><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation><nlm:aff id="A42">Department of Histopathology, University of Szeged, Szeged 6720, Hungary</nlm:aff></affiliation></author><author><name sortKey="Wilson, Beverly" sort="Wilson, Beverly" uniqKey="Wilson B" first="Beverly" last="Wilson">Beverly Wilson</name><affiliation><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name><affiliation><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff></affiliation></author><author><name sortKey="Carret, Anne Sophie" sort="Carret, Anne Sophie" uniqKey="Carret A" first="Anne-Sophie" last="Carret">Anne-Sophie Carret</name><affiliation><nlm:aff id="A43">Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada</nlm:aff></affiliation></author><author><name sortKey="Van Meter, Timothy E" sort="Van Meter, Timothy E" uniqKey="Van Meter T" first="Timothy E." last="Van Meter">Timothy E. Van Meter</name><affiliation><nlm:aff id="A44">Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA</nlm:aff></affiliation></author><author><name sortKey="Hwang, Eugene I" sort="Hwang, Eugene I" uniqKey="Hwang E" first="Eugene I." last="Hwang">Eugene I. Hwang</name><affiliation><nlm:aff id="A45">Department of Oncology, Children’s National Medical Center, Washington, DC 20010, USA</nlm:aff></affiliation></author><author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><affiliation><nlm:aff id="A46">Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff></affiliation></author><author><name sortKey="Chiou, Shih Hwa" sort="Chiou, Shih Hwa" uniqKey="Chiou S" first="Shih-Hwa" last="Chiou">Shih-Hwa Chiou</name><affiliation><nlm:aff id="A47">Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Hideo" sort="Nakamura, Hideo" uniqKey="Nakamura H" first="Hideo" last="Nakamura">Hideo Nakamura</name><affiliation><nlm:aff id="A48">Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan</nlm:aff></affiliation></author><author><name sortKey="Toledano, Helen" sort="Toledano, Helen" uniqKey="Toledano H" first="Helen" last="Toledano">Helen Toledano</name><affiliation><nlm:aff id="A49">Department of Pediatric Hematology Oncology, Children’s Medical Center of Israel, Petach Tikva 49202, Isreal</nlm:aff></affiliation></author><author><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name><affiliation><nlm:aff id="A50">Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel</nlm:aff></affiliation></author><author><name sortKey="Fults, Daniel" sort="Fults, Daniel" uniqKey="Fults D" first="Daniel" last="Fults">Daniel Fults</name><affiliation><nlm:aff id="A51">Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author><author><name sortKey="Wataya, Takafumi" sort="Wataya, Takafumi" uniqKey="Wataya T" first="Takafumi" last="Wataya">Takafumi Wataya</name><affiliation><nlm:aff id="A52">Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, Japan</nlm:aff></affiliation></author><author><name sortKey="Fryer, Chris" sort="Fryer, Chris" uniqKey="Fryer C" first="Chris" last="Fryer">Chris Fryer</name><affiliation><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff></affiliation></author><author><name sortKey="Eisenstat, David D" sort="Eisenstat, David D" uniqKey="Eisenstat D" first="David D." last="Eisenstat">David D. Eisenstat</name><affiliation><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Scheinemann, Katrin" sort="Scheinemann, Katrin" uniqKey="Scheinemann K" first="Katrin" last="Scheinemann">Katrin Scheinemann</name><affiliation><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff></affiliation></author><author><name sortKey="Fleming, Adam J" sort="Fleming, Adam J" uniqKey="Fleming A" first="Adam J." last="Fleming">Adam J. Fleming</name><affiliation><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff></affiliation></author><author><name sortKey="Johnston, Donna L" sort="Johnston, Donna L" uniqKey="Johnston D" first="Donna L." last="Johnston">Donna L. Johnston</name><affiliation><nlm:aff id="A54">Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff></affiliation></author><author><name sortKey="Michaud, Jean" sort="Michaud, Jean" uniqKey="Michaud J" first="Jean" last="Michaud">Jean Michaud</name><affiliation><nlm:aff id="A55">Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff></affiliation></author><author><name sortKey="Zelcer, Shayna" sort="Zelcer, Shayna" uniqKey="Zelcer S" first="Shayna" last="Zelcer">Shayna Zelcer</name><affiliation><nlm:aff id="A56">Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5, Canada</nlm:aff></affiliation></author><author><name sortKey="Hammond, Robert" sort="Hammond, Robert" uniqKey="Hammond R" first="Robert" last="Hammond">Robert Hammond</name><affiliation><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff></affiliation></author><author><name sortKey="Afzal, Samina" sort="Afzal, Samina" uniqKey="Afzal S" first="Samina" last="Afzal">Samina Afzal</name><affiliation><nlm:aff id="A58">Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada</nlm:aff></affiliation></author><author><name sortKey="Ramsay, David A" sort="Ramsay, David A" uniqKey="Ramsay D" first="David A." last="Ramsay">David A. Ramsay</name><affiliation><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff></affiliation></author><author><name sortKey="Sirachainan, Nongnuch" sort="Sirachainan, Nongnuch" uniqKey="Sirachainan N" first="Nongnuch" last="Sirachainan">Nongnuch Sirachainan</name><affiliation><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff></affiliation></author><author><name sortKey="Hongeng, Suradej" sort="Hongeng, Suradej" uniqKey="Hongeng S" first="Suradej" last="Hongeng">Suradej Hongeng</name><affiliation><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff></affiliation></author><author><name sortKey="Larbcharoensub, Noppadol" sort="Larbcharoensub, Noppadol" uniqKey="Larbcharoensub N" first="Noppadol" last="Larbcharoensub">Noppadol Larbcharoensub</name><affiliation><nlm:aff id="A60">Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Grundy, Richard G" sort="Grundy, Richard G" uniqKey="Grundy R" first="Richard G." last="Grundy">Richard G. Grundy</name><affiliation><nlm:aff id="A61">Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England</nlm:aff></affiliation></author><author><name sortKey="Lulla, Rishi R" sort="Lulla, Rishi R" uniqKey="Lulla R" first="Rishi R." last="Lulla">Rishi R. Lulla</name><affiliation><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff></affiliation></author><author><name sortKey="Fangusaro, Jason R" sort="Fangusaro, Jason R" uniqKey="Fangusaro J" first="Jason R." last="Fangusaro">Jason R. Fangusaro</name><affiliation><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff></affiliation></author><author><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Grant, Ronald" sort="Grant, Ronald" uniqKey="Grant R" first="Ronald" last="Grant">Ronald Grant</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Mcglade, C Jane" sort="Mcglade, C Jane" uniqKey="Mcglade C" first="C. Jane" last="Mcglade">C. Jane Mcglade</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Nicolaides, Theodore" sort="Nicolaides, Theodore" uniqKey="Nicolaides T" first="Theodore" last="Nicolaides">Theodore Nicolaides</name><affiliation><nlm:aff id="A63">Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff></affiliation></author><author><name sortKey="Tihan, Tarik" sort="Tihan, Tarik" uniqKey="Tihan T" first="Tarik" last="Tihan">Tarik Tihan</name><affiliation><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff></affiliation></author><author><name sortKey="Phillips, Joanna" sort="Phillips, Joanna" uniqKey="Phillips J" first="Joanna" last="Phillips">Joanna Phillips</name><affiliation><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff></affiliation></author><author><name sortKey="Majewski, Jacek" sort="Majewski, Jacek" uniqKey="Majewski J" first="Jacek" last="Majewski">Jacek Majewski</name><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Montpetit, Alexandre" sort="Montpetit, Alexandre" uniqKey="Montpetit A" first="Alexandre" last="Montpetit">Alexandre Montpetit</name><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Bourque, Guillaume" sort="Bourque, Guillaume" uniqKey="Bourque G" first="Guillaume" last="Bourque">Guillaume Bourque</name><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Bader, Gary D" sort="Bader, Gary D" uniqKey="Bader G" first="Gary D." last="Bader">Gary D. Bader</name><affiliation><nlm:aff id="A4">Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Reddy, Alyssa T" sort="Reddy, Alyssa T" uniqKey="Reddy A" first="Alyssa T." last="Reddy">Alyssa T. Reddy</name><affiliation><nlm:aff id="A65">Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA</nlm:aff></affiliation></author><author><name sortKey="Gillespie, G Yancey" sort="Gillespie, G Yancey" uniqKey="Gillespie G" first="G. Yancey" last="Gillespie">G. Yancey Gillespie</name><affiliation><nlm:aff id="A66">Department of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA</nlm:aff></affiliation></author><author><name sortKey="Warmuth Metz, Monika" sort="Warmuth Metz, Monika" uniqKey="Warmuth Metz M" first="Monika" last="Warmuth-Metz">Monika Warmuth-Metz</name><affiliation><nlm:aff id="A67">Department of Neuroradiology, University of Würzburg, Würzburg 97070, Germany</nlm:aff></affiliation></author><author><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name><affiliation><nlm:aff id="A68">Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Lupien, Mathieu" sort="Lupien, Mathieu" uniqKey="Lupien M" first="Mathieu" last="Lupien">Mathieu Lupien</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Brudno, Michael" sort="Brudno, Michael" uniqKey="Brudno M" first="Michael" last="Brudno">Michael Brudno</name><affiliation><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name><affiliation><nlm:aff id="A69">Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff></affiliation></author><author><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name><affiliation><nlm:aff id="A70">Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany</nlm:aff></affiliation></author><author><name sortKey="Judkins, Alexander R" sort="Judkins, Alexander R" uniqKey="Judkins A" first="Alexander R." last="Judkins">Alexander R. Judkins</name><affiliation><nlm:aff id="A71">Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA</nlm:aff></affiliation></author><author><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Kim, Seung Ki" sort="Kim, Seung Ki" uniqKey="Kim S" first="Seung-Ki" last="Kim">Seung-Ki Kim</name><affiliation><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff></affiliation></author><author><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B." last="Dirks">Peter B. Dirks</name><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Erdreich Epstein, Anat" sort="Erdreich Epstein, Anat" uniqKey="Erdreich Epstein A" first="Anat" last="Erdreich-Epstein">Anat Erdreich-Epstein</name><affiliation><nlm:aff id="A72">Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA</nlm:aff></affiliation></author><author><name sortKey="Arrowsmith, Cheryl H" sort="Arrowsmith, Cheryl H" uniqKey="Arrowsmith C" first="Cheryl H." last="Arrowsmith">Cheryl H. Arrowsmith</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="De Carvalho, Daniel D" sort="De Carvalho, Daniel D" uniqKey="De Carvalho D" first="Daniel D." last="De Carvalho">Daniel D. De Carvalho</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Rutka, James T" sort="Rutka, James T" uniqKey="Rutka J" first="James T." last="Rutka">James T. Rutka</name><affiliation><nlm:aff id="A6">Department of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><affiliation><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27960086</idno><idno type="pmc">5500911</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911</idno><idno type="RBID">PMC:5500911</idno><idno type="doi">10.1016/j.ccell.2016.11.003</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001E04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors</title><author><name sortKey="Torchia, Jonathon" sort="Torchia, Jonathon" uniqKey="Torchia J" first="Jonathon" last="Torchia">Jonathon Torchia</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Golbourn, Brian" sort="Golbourn, Brian" uniqKey="Golbourn B" first="Brian" last="Golbourn">Brian Golbourn</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Feng, Shengrui" sort="Feng, Shengrui" uniqKey="Feng S" first="Shengrui" last="Feng">Shengrui Feng</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Ho, King Ching" sort="Ho, King Ching" uniqKey="Ho K" first="King Ching" last="Ho">King Ching Ho</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Sin Chan, Patrick" sort="Sin Chan, Patrick" uniqKey="Sin Chan P" first="Patrick" last="Sin-Chan">Patrick Sin-Chan</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Vasiljevic, Alexandre" sort="Vasiljevic, Alexandre" uniqKey="Vasiljevic A" first="Alexandre" last="Vasiljevic">Alexandre Vasiljevic</name><affiliation><nlm:aff id="A15">Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France</nlm:aff></affiliation></author><author><name sortKey="Norman, Joseph D" sort="Norman, Joseph D" uniqKey="Norman J" first="Joseph D." last="Norman">Joseph D. Norman</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Guilhamon, Paul" sort="Guilhamon, Paul" uniqKey="Guilhamon P" first="Paul" last="Guilhamon">Paul Guilhamon</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Garzia, Livia" sort="Garzia, Livia" uniqKey="Garzia L" first="Livia" last="Garzia">Livia Garzia</name><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Agamez, Natalia R" sort="Agamez, Natalia R" uniqKey="Agamez N" first="Natalia R." last="Agamez">Natalia R. Agamez</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Lu, Mei" sort="Lu, Mei" uniqKey="Lu M" first="Mei" last="Lu">Mei Lu</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Chan, Tiffany S" sort="Chan, Tiffany S" uniqKey="Chan T" first="Tiffany S." last="Chan">Tiffany S. Chan</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Picard, Daniel" sort="Picard, Daniel" uniqKey="Picard D" first="Daniel" last="Picard">Daniel Picard</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="De Antonellis, Pasqualino" sort="De Antonellis, Pasqualino" uniqKey="De Antonellis P" first="Pasqualino" last="De Antonellis">Pasqualino De Antonellis</name><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Khuong Quang, Dong Anh" sort="Khuong Quang, Dong Anh" uniqKey="Khuong Quang D" first="Dong-Anh" last="Khuong-Quang">Dong-Anh Khuong-Quang</name><affiliation><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Planello, Aline C" sort="Planello, Aline C" uniqKey="Planello A" first="Aline C." last="Planello">Aline C. Planello</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Zeller, Constanze" sort="Zeller, Constanze" uniqKey="Zeller C" first="Constanze" last="Zeller">Constanze Zeller</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Barsyte Lovejoy, Dalia" sort="Barsyte Lovejoy, Dalia" uniqKey="Barsyte Lovejoy D" first="Dalia" last="Barsyte-Lovejoy">Dalia Barsyte-Lovejoy</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Lafay Cousin, Lucie" sort="Lafay Cousin, Lucie" uniqKey="Lafay Cousin L" first="Lucie" last="Lafay-Cousin">Lucie Lafay-Cousin</name><affiliation><nlm:aff id="A20">Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8, Canada</nlm:aff></affiliation></author><author><name sortKey="Letourneau, Louis" sort="Letourneau, Louis" uniqKey="Letourneau L" first="Louis" last="Letourneau">Louis Letourneau</name><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Bourgey, Mathieu" sort="Bourgey, Mathieu" uniqKey="Bourgey M" first="Mathieu" last="Bourgey">Mathieu Bourgey</name><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Yu, Man" sort="Yu, Man" uniqKey="Yu M" first="Man" last="Yu">Man Yu</name><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Gendoo, Deena M A" sort="Gendoo, Deena M A" uniqKey="Gendoo D" first="Deena M. A." last="Gendoo">Deena M. A. Gendoo</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Dzamba, Misko" sort="Dzamba, Misko" uniqKey="Dzamba M" first="Misko" last="Dzamba">Misko Dzamba</name><affiliation><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Barszczyk, Mark" sort="Barszczyk, Mark" uniqKey="Barszczyk M" first="Mark" last="Barszczyk">Mark Barszczyk</name><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Medina, Tiago" sort="Medina, Tiago" uniqKey="Medina T" first="Tiago" last="Medina">Tiago Medina</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Riemenschneider, Alexandra N" sort="Riemenschneider, Alexandra N" uniqKey="Riemenschneider A" first="Alexandra N." last="Riemenschneider">Alexandra N. Riemenschneider</name><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Morrissy, A Sorana" sort="Morrissy, A Sorana" uniqKey="Morrissy A" first="A. Sorana" last="Morrissy">A. Sorana Morrissy</name><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Ra, Young Shin" sort="Ra, Young Shin" uniqKey="Ra Y" first="Young-Shin" last="Ra">Young-Shin Ra</name><affiliation><nlm:aff id="A22">Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea</nlm:aff></affiliation></author><author><name sortKey="Ramaswamy, Vijay" sort="Ramaswamy, Vijay" uniqKey="Ramaswamy V" first="Vijay" last="Ramaswamy">Vijay Ramaswamy</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Remke, Marc" sort="Remke, Marc" uniqKey="Remke M" first="Marc" last="Remke">Marc Remke</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Dunham, Christopher P" sort="Dunham, Christopher P" uniqKey="Dunham C" first="Christopher P." last="Dunham">Christopher P. Dunham</name><affiliation><nlm:aff id="A23">Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff></affiliation></author><author><name sortKey="Yip, Stephen" sort="Yip, Stephen" uniqKey="Yip S" first="Stephen" last="Yip">Stephen Yip</name><affiliation><nlm:aff id="A25">Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Ng, Ho Keung" sort="Ng, Ho Keung" uniqKey="Ng H" first="Ho-Keung" last="Ng">Ho-Keung Ng</name><affiliation><nlm:aff id="A26">Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China</nlm:aff></affiliation></author><author><name sortKey="Lu, Jian Qiang" sort="Lu, Jian Qiang" uniqKey="Lu J" first="Jian-Qiang" last="Lu">Jian-Qiang Lu</name><affiliation><nlm:aff id="A27">Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Mehta, Vivek" sort="Mehta, Vivek" uniqKey="Mehta V" first="Vivek" last="Mehta">Vivek Mehta</name><affiliation><nlm:aff id="A28">Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Albrecht, Steffen" sort="Albrecht, Steffen" uniqKey="Albrecht S" first="Steffen" last="Albrecht">Steffen Albrecht</name><affiliation><nlm:aff id="A18">Department of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Pimentel, Jose" sort="Pimentel, Jose" uniqKey="Pimentel J" first="Jose" last="Pimentel">Jose Pimentel</name><affiliation><nlm:aff id="A30">Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff></affiliation></author><author><name sortKey="Chan, Jennifer A" sort="Chan, Jennifer A" uniqKey="Chan J" first="Jennifer A." last="Chan">Jennifer A. Chan</name><affiliation><nlm:aff id="A21">Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada</nlm:aff></affiliation></author><author><name sortKey="Somers, Gino R" sort="Somers, Gino R" uniqKey="Somers G" first="Gino R." last="Somers">Gino R. Somers</name><affiliation><nlm:aff id="A12">Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Faria, Claudia C" sort="Faria, Claudia C" uniqKey="Faria C" first="Claudia C." last="Faria">Claudia C. Faria</name><affiliation><nlm:aff id="A31">Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</nlm:aff></affiliation></author><author><name sortKey="Roque, Lucia" sort="Roque, Lucia" uniqKey="Roque L" first="Lucia" last="Roque">Lucia Roque</name><affiliation><nlm:aff id="A32">Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal</nlm:aff></affiliation></author><author><name sortKey="Fouladi, Maryam" sort="Fouladi, Maryam" uniqKey="Fouladi M" first="Maryam" last="Fouladi">Maryam Fouladi</name><affiliation><nlm:aff id="A33">Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA</nlm:aff></affiliation></author><author><name sortKey="Hoffman, Lindsey M" sort="Hoffman, Lindsey M" uniqKey="Hoffman L" first="Lindsey M." last="Hoffman">Lindsey M. Hoffman</name><affiliation><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff></affiliation></author><author><name sortKey="Moore, Andrew S" sort="Moore, Andrew S" uniqKey="Moore A" first="Andrew S." last="Moore">Andrew S. Moore</name><affiliation><nlm:aff id="A35">Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia</nlm:aff></affiliation></author><author><name sortKey="Wang, Yin" sort="Wang, Yin" uniqKey="Wang Y" first="Yin" last="Wang">Yin Wang</name><affiliation><nlm:aff id="A36">Research Institute of Health Development Strategies, Fudan University, Shanghai 200032, China</nlm:aff></affiliation></author><author><name sortKey="Choi, Seung Ah" sort="Choi, Seung Ah" uniqKey="Choi S" first="Seung Ah" last="Choi">Seung Ah Choi</name><affiliation><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff></affiliation></author><author><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R." last="Hansford">Jordan R. Hansford</name><affiliation><nlm:aff id="A38">Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia</nlm:aff></affiliation></author><author><name sortKey="Catchpoole, Daniel" sort="Catchpoole, Daniel" uniqKey="Catchpoole D" first="Daniel" last="Catchpoole">Daniel Catchpoole</name><affiliation><nlm:aff id="A39">Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia</nlm:aff></affiliation></author><author><name sortKey="Birks, Diane K" sort="Birks, Diane K" uniqKey="Birks D" first="Diane K." last="Birks">Diane K. Birks</name><affiliation><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff></affiliation></author><author><name sortKey="Foreman, Nicholas K" sort="Foreman, Nicholas K" uniqKey="Foreman N" first="Nicholas K." last="Foreman">Nicholas K. Foreman</name><affiliation><nlm:aff id="A34">Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</nlm:aff></affiliation></author><author><name sortKey="Strother, Doug" sort="Strother, Doug" uniqKey="Strother D" first="Doug" last="Strother">Doug Strother</name><affiliation><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Klekner, Almos" sort="Klekner, Almos" uniqKey="Klekner A" first="Almos" last="Klekner">Almos Klekner</name><affiliation><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff></affiliation></author><author><name sortKey="Bognar, Laszl" sort="Bognar, Laszl" uniqKey="Bognar L" first="Laszl" last="Bognár">Laszl Bognár</name><affiliation><nlm:aff id="A40">Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</nlm:aff></affiliation></author><author><name sortKey="Garami, Mikl S" sort="Garami, Mikl S" uniqKey="Garami M" first="Mikl S" last="Garami">Mikl S Garami</name><affiliation><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff></affiliation></author><author><name sortKey="Hauser, Peter" sort="Hauser, Peter" uniqKey="Hauser P" first="Péter" last="Hauser">Péter Hauser</name><affiliation><nlm:aff id="A41">Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</nlm:aff></affiliation></author><author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobágyi">Tibor Hortobágyi</name><affiliation><nlm:aff id="A42">Department of Histopathology, University of Szeged, Szeged 6720, Hungary</nlm:aff></affiliation></author><author><name sortKey="Wilson, Beverly" sort="Wilson, Beverly" uniqKey="Wilson B" first="Beverly" last="Wilson">Beverly Wilson</name><affiliation><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Hukin, Juliette" sort="Hukin, Juliette" uniqKey="Hukin J" first="Juliette" last="Hukin">Juliette Hukin</name><affiliation><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff></affiliation></author><author><name sortKey="Carret, Anne Sophie" sort="Carret, Anne Sophie" uniqKey="Carret A" first="Anne-Sophie" last="Carret">Anne-Sophie Carret</name><affiliation><nlm:aff id="A43">Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada</nlm:aff></affiliation></author><author><name sortKey="Van Meter, Timothy E" sort="Van Meter, Timothy E" uniqKey="Van Meter T" first="Timothy E." last="Van Meter">Timothy E. Van Meter</name><affiliation><nlm:aff id="A44">Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA</nlm:aff></affiliation></author><author><name sortKey="Hwang, Eugene I" sort="Hwang, Eugene I" uniqKey="Hwang E" first="Eugene I." last="Hwang">Eugene I. Hwang</name><affiliation><nlm:aff id="A45">Department of Oncology, Children’s National Medical Center, Washington, DC 20010, USA</nlm:aff></affiliation></author><author><name sortKey="Gajjar, Amar" sort="Gajjar, Amar" uniqKey="Gajjar A" first="Amar" last="Gajjar">Amar Gajjar</name><affiliation><nlm:aff id="A46">Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff></affiliation></author><author><name sortKey="Chiou, Shih Hwa" sort="Chiou, Shih Hwa" uniqKey="Chiou S" first="Shih-Hwa" last="Chiou">Shih-Hwa Chiou</name><affiliation><nlm:aff id="A47">Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Hideo" sort="Nakamura, Hideo" uniqKey="Nakamura H" first="Hideo" last="Nakamura">Hideo Nakamura</name><affiliation><nlm:aff id="A48">Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan</nlm:aff></affiliation></author><author><name sortKey="Toledano, Helen" sort="Toledano, Helen" uniqKey="Toledano H" first="Helen" last="Toledano">Helen Toledano</name><affiliation><nlm:aff id="A49">Department of Pediatric Hematology Oncology, Children’s Medical Center of Israel, Petach Tikva 49202, Isreal</nlm:aff></affiliation></author><author><name sortKey="Fried, Iris" sort="Fried, Iris" uniqKey="Fried I" first="Iris" last="Fried">Iris Fried</name><affiliation><nlm:aff id="A50">Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel</nlm:aff></affiliation></author><author><name sortKey="Fults, Daniel" sort="Fults, Daniel" uniqKey="Fults D" first="Daniel" last="Fults">Daniel Fults</name><affiliation><nlm:aff id="A51">Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author><author><name sortKey="Wataya, Takafumi" sort="Wataya, Takafumi" uniqKey="Wataya T" first="Takafumi" last="Wataya">Takafumi Wataya</name><affiliation><nlm:aff id="A52">Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, Japan</nlm:aff></affiliation></author><author><name sortKey="Fryer, Chris" sort="Fryer, Chris" uniqKey="Fryer C" first="Chris" last="Fryer">Chris Fryer</name><affiliation><nlm:aff id="A24">Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</nlm:aff></affiliation></author><author><name sortKey="Eisenstat, David D" sort="Eisenstat, David D" uniqKey="Eisenstat D" first="David D." last="Eisenstat">David D. Eisenstat</name><affiliation><nlm:aff id="A29">Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</nlm:aff></affiliation></author><author><name sortKey="Scheinemann, Katrin" sort="Scheinemann, Katrin" uniqKey="Scheinemann K" first="Katrin" last="Scheinemann">Katrin Scheinemann</name><affiliation><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff></affiliation></author><author><name sortKey="Fleming, Adam J" sort="Fleming, Adam J" uniqKey="Fleming A" first="Adam J." last="Fleming">Adam J. Fleming</name><affiliation><nlm:aff id="A53">Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</nlm:aff></affiliation></author><author><name sortKey="Johnston, Donna L" sort="Johnston, Donna L" uniqKey="Johnston D" first="Donna L." last="Johnston">Donna L. Johnston</name><affiliation><nlm:aff id="A54">Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff></affiliation></author><author><name sortKey="Michaud, Jean" sort="Michaud, Jean" uniqKey="Michaud J" first="Jean" last="Michaud">Jean Michaud</name><affiliation><nlm:aff id="A55">Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</nlm:aff></affiliation></author><author><name sortKey="Zelcer, Shayna" sort="Zelcer, Shayna" uniqKey="Zelcer S" first="Shayna" last="Zelcer">Shayna Zelcer</name><affiliation><nlm:aff id="A56">Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5, Canada</nlm:aff></affiliation></author><author><name sortKey="Hammond, Robert" sort="Hammond, Robert" uniqKey="Hammond R" first="Robert" last="Hammond">Robert Hammond</name><affiliation><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff></affiliation></author><author><name sortKey="Afzal, Samina" sort="Afzal, Samina" uniqKey="Afzal S" first="Samina" last="Afzal">Samina Afzal</name><affiliation><nlm:aff id="A58">Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada</nlm:aff></affiliation></author><author><name sortKey="Ramsay, David A" sort="Ramsay, David A" uniqKey="Ramsay D" first="David A." last="Ramsay">David A. Ramsay</name><affiliation><nlm:aff id="A57">Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</nlm:aff></affiliation></author><author><name sortKey="Sirachainan, Nongnuch" sort="Sirachainan, Nongnuch" uniqKey="Sirachainan N" first="Nongnuch" last="Sirachainan">Nongnuch Sirachainan</name><affiliation><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff></affiliation></author><author><name sortKey="Hongeng, Suradej" sort="Hongeng, Suradej" uniqKey="Hongeng S" first="Suradej" last="Hongeng">Suradej Hongeng</name><affiliation><nlm:aff id="A59">Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</nlm:aff></affiliation></author><author><name sortKey="Larbcharoensub, Noppadol" sort="Larbcharoensub, Noppadol" uniqKey="Larbcharoensub N" first="Noppadol" last="Larbcharoensub">Noppadol Larbcharoensub</name><affiliation><nlm:aff id="A60">Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand</nlm:aff></affiliation></author><author><name sortKey="Grundy, Richard G" sort="Grundy, Richard G" uniqKey="Grundy R" first="Richard G." last="Grundy">Richard G. Grundy</name><affiliation><nlm:aff id="A61">Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England</nlm:aff></affiliation></author><author><name sortKey="Lulla, Rishi R" sort="Lulla, Rishi R" uniqKey="Lulla R" first="Rishi R." last="Lulla">Rishi R. Lulla</name><affiliation><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff></affiliation></author><author><name sortKey="Fangusaro, Jason R" sort="Fangusaro, Jason R" uniqKey="Fangusaro J" first="Jason R." last="Fangusaro">Jason R. Fangusaro</name><affiliation><nlm:aff id="A62">Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</nlm:aff></affiliation></author><author><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Bartels, Ute" sort="Bartels, Ute" uniqKey="Bartels U" first="Ute" last="Bartels">Ute Bartels</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Grant, Ronald" sort="Grant, Ronald" uniqKey="Grant R" first="Ronald" last="Grant">Ronald Grant</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Malkin, David" sort="Malkin, David" uniqKey="Malkin D" first="David" last="Malkin">David Malkin</name><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Mcglade, C Jane" sort="Mcglade, C Jane" uniqKey="Mcglade C" first="C. Jane" last="Mcglade">C. Jane Mcglade</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Nicolaides, Theodore" sort="Nicolaides, Theodore" uniqKey="Nicolaides T" first="Theodore" last="Nicolaides">Theodore Nicolaides</name><affiliation><nlm:aff id="A63">Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff></affiliation></author><author><name sortKey="Tihan, Tarik" sort="Tihan, Tarik" uniqKey="Tihan T" first="Tarik" last="Tihan">Tarik Tihan</name><affiliation><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff></affiliation></author><author><name sortKey="Phillips, Joanna" sort="Phillips, Joanna" uniqKey="Phillips J" first="Joanna" last="Phillips">Joanna Phillips</name><affiliation><nlm:aff id="A64">Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</nlm:aff></affiliation></author><author><name sortKey="Majewski, Jacek" sort="Majewski, Jacek" uniqKey="Majewski J" first="Jacek" last="Majewski">Jacek Majewski</name><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Montpetit, Alexandre" sort="Montpetit, Alexandre" uniqKey="Montpetit A" first="Alexandre" last="Montpetit">Alexandre Montpetit</name><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Bourque, Guillaume" sort="Bourque, Guillaume" uniqKey="Bourque G" first="Guillaume" last="Bourque">Guillaume Bourque</name><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A19">Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Bader, Gary D" sort="Bader, Gary D" uniqKey="Bader G" first="Gary D." last="Bader">Gary D. Bader</name><affiliation><nlm:aff id="A4">Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation></author><author><name sortKey="Reddy, Alyssa T" sort="Reddy, Alyssa T" uniqKey="Reddy A" first="Alyssa T." last="Reddy">Alyssa T. Reddy</name><affiliation><nlm:aff id="A65">Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA</nlm:aff></affiliation></author><author><name sortKey="Gillespie, G Yancey" sort="Gillespie, G Yancey" uniqKey="Gillespie G" first="G. Yancey" last="Gillespie">G. Yancey Gillespie</name><affiliation><nlm:aff id="A66">Department of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA</nlm:aff></affiliation></author><author><name sortKey="Warmuth Metz, Monika" sort="Warmuth Metz, Monika" uniqKey="Warmuth Metz M" first="Monika" last="Warmuth-Metz">Monika Warmuth-Metz</name><affiliation><nlm:aff id="A67">Department of Neuroradiology, University of Würzburg, Würzburg 97070, Germany</nlm:aff></affiliation></author><author><name sortKey="Rutkowski, Stefan" sort="Rutkowski, Stefan" uniqKey="Rutkowski S" first="Stefan" last="Rutkowski">Stefan Rutkowski</name><affiliation><nlm:aff id="A68">Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Lupien, Mathieu" sort="Lupien, Mathieu" uniqKey="Lupien M" first="Mathieu" last="Lupien">Mathieu Lupien</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Brudno, Michael" sort="Brudno, Michael" uniqKey="Brudno M" first="Michael" last="Brudno">Michael Brudno</name><affiliation><nlm:aff id="A5">Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Schuller, Ulrich" sort="Schuller, Ulrich" uniqKey="Schuller U" first="Ulrich" last="Schüller">Ulrich Schüller</name><affiliation><nlm:aff id="A69">Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</nlm:aff></affiliation></author><author><name sortKey="Pietsch, Torsten" sort="Pietsch, Torsten" uniqKey="Pietsch T" first="Torsten" last="Pietsch">Torsten Pietsch</name><affiliation><nlm:aff id="A70">Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany</nlm:aff></affiliation></author><author><name sortKey="Judkins, Alexander R" sort="Judkins, Alexander R" uniqKey="Judkins A" first="Alexander R." last="Judkins">Alexander R. Judkins</name><affiliation><nlm:aff id="A71">Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA</nlm:aff></affiliation></author><author><name sortKey="Hawkins, Cynthia E" sort="Hawkins, Cynthia E" uniqKey="Hawkins C" first="Cynthia E." last="Hawkins">Cynthia E. Hawkins</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Bouffet, Eric" sort="Bouffet, Eric" uniqKey="Bouffet E" first="Eric" last="Bouffet">Eric Bouffet</name><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Kim, Seung Ki" sort="Kim, Seung Ki" uniqKey="Kim S" first="Seung-Ki" last="Kim">Seung-Ki Kim</name><affiliation><nlm:aff id="A37">Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</nlm:aff></affiliation></author><author><name sortKey="Dirks, Peter B" sort="Dirks, Peter B" uniqKey="Dirks P" first="Peter B." last="Dirks">Peter B. Dirks</name><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Taylor, Michael D" sort="Taylor, Michael D" uniqKey="Taylor M" first="Michael D." last="Taylor">Michael D. Taylor</name><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A10">Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Erdreich Epstein, Anat" sort="Erdreich Epstein, Anat" uniqKey="Erdreich Epstein A" first="Anat" last="Erdreich-Epstein">Anat Erdreich-Epstein</name><affiliation><nlm:aff id="A72">Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA</nlm:aff></affiliation></author><author><name sortKey="Arrowsmith, Cheryl H" sort="Arrowsmith, Cheryl H" uniqKey="Arrowsmith C" first="Cheryl H." last="Arrowsmith">Cheryl H. Arrowsmith</name><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="De Carvalho, Daniel D" sort="De Carvalho, Daniel D" uniqKey="De Carvalho D" first="Daniel D." last="De Carvalho">Daniel D. De Carvalho</name><affiliation><nlm:aff id="A3">Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A14">Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</nlm:aff></affiliation></author><author><name sortKey="Rutka, James T" sort="Rutka, James T" uniqKey="Rutka J" first="James T." last="Rutka">James T. Rutka</name><affiliation><nlm:aff id="A6">Department of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A8">Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author><author><name sortKey="Jabado, Nada" sort="Jabado, Nada" uniqKey="Jabado N" first="Nada" last="Jabado">Nada Jabado</name><affiliation><nlm:aff id="A16">Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A17">Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</nlm:aff></affiliation></author><author><name sortKey="Huang, Annie" sort="Huang, Annie" uniqKey="Huang A" first="Annie" last="Huang">Annie Huang</name><affiliation><nlm:aff id="A1">Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation><affiliation><nlm:aff id="A13">Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="ISSN">1535-6108</idno><idno type="eISSN">1878-3686</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P1">We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101130617</journal-id><journal-id journal-id-type="pubmed-jr-id">29778</journal-id><journal-id journal-id-type="nlm-ta">Cancer Cell</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Cell</journal-id><journal-title-group><journal-title>Cancer cell</journal-title></journal-title-group><issn pub-type="ppub">1535-6108</issn><issn pub-type="epub">1878-3686</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27960086</article-id><article-id pub-id-type="pmc">5500911</article-id><article-id pub-id-type="doi">10.1016/j.ccell.2016.11.003</article-id><article-id pub-id-type="manuscript">NIHMS870627</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Torchia</surname><given-names>Jonathon</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref><xref rid="FN2" ref-type="author-notes">73</xref></contrib><contrib contrib-type="author"><name><surname>Golbourn</surname><given-names>Brian</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A13">13</xref><xref rid="FN2" ref-type="author-notes">73</xref></contrib><contrib contrib-type="author"><name><surname>Feng</surname><given-names>Shengrui</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A14">14</xref><xref rid="FN2" ref-type="author-notes">73</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>King Ching</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref><xref rid="FN2" ref-type="author-notes">73</xref></contrib><contrib contrib-type="author"><name><surname>Sin-Chan</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Vasiljevic</surname><given-names>Alexandre</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Norman</surname><given-names>Joseph D.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Guilhamon</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Garzia</surname><given-names>Livia</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Agamez</surname><given-names>Natalia R.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Lu</surname><given-names>Mei</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Tiffany S.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Picard</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>de Antonellis</surname><given-names>Pasqualino</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Khuong-Quang</surname><given-names>Dong-Anh</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Planello</surname><given-names>Aline C.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Zeller</surname><given-names>Constanze</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Barsyte-Lovejoy</surname><given-names>Dalia</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Lafay-Cousin</surname><given-names>Lucie</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Letourneau</surname><given-names>Louis</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Bourgey</surname><given-names>Mathieu</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Man</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Gendoo</surname><given-names>Deena M.A.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Dzamba</surname><given-names>Misko</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Barszczyk</surname><given-names>Mark</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Medina</surname><given-names>Tiago</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Riemenschneider</surname><given-names>Alexandra N.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Morrissy</surname><given-names>A. Sorana</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Ra</surname><given-names>Young-Shin</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Ramaswamy</surname><given-names>Vijay</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Remke</surname><given-names>Marc</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Dunham</surname><given-names>Christopher P.</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Yip</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib 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R.</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Faria</surname><given-names>Claudia C.</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Roque</surname><given-names>Lucia</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Fouladi</surname><given-names>Maryam</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Hoffman</surname><given-names>Lindsey M.</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Moore</surname><given-names>Andrew S.</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yin</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib 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D.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Scheinemann</surname><given-names>Katrin</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Fleming</surname><given-names>Adam J.</given-names></name><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Johnston</surname><given-names>Donna L.</given-names></name><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Michaud</surname><given-names>Jean</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Zelcer</surname><given-names>Shayna</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Hammond</surname><given-names>Robert</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Afzal</surname><given-names>Samina</given-names></name><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Ramsay</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Sirachainan</surname><given-names>Nongnuch</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Hongeng</surname><given-names>Suradej</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Larbcharoensub</surname><given-names>Noppadol</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Grundy</surname><given-names>Richard G.</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib 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contrib-type="author"><name><surname>McGlade</surname><given-names>C. Jane</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Nicolaides</surname><given-names>Theodore</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Tihan</surname><given-names>Tarik</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Joanna</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Majewski</surname><given-names>Jacek</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Montpetit</surname><given-names>Alexandre</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Bourque</surname><given-names>Guillaume</given-names></name><xref ref-type="aff" rid="A17">17</xref><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Bader</surname><given-names>Gary D.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Reddy</surname><given-names>Alyssa T.</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Gillespie</surname><given-names>G. Yancey</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Warmuth-Metz</surname><given-names>Monika</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Rutkowski</surname><given-names>Stefan</given-names></name><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Tabori</surname><given-names>Uri</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Lupien</surname><given-names>Mathieu</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Brudno</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Schüller</surname><given-names>Ulrich</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Pietsch</surname><given-names>Torsten</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Judkins</surname><given-names>Alexander R.</given-names></name><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Hawkins</surname><given-names>Cynthia E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Bouffet</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Seung-Ki</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Dirks</surname><given-names>Peter B.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Taylor</surname><given-names>Michael D.</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Erdreich-Epstein</surname><given-names>Anat</given-names></name><xref ref-type="aff" rid="A72">72</xref></contrib><contrib contrib-type="author"><name><surname>Arrowsmith</surname><given-names>Cheryl H.</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>De Carvalho</surname><given-names>Daniel D.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A14">14</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Rutka</surname><given-names>James T.</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A13">13</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Jabado</surname><given-names>Nada</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Annie</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A13">13</xref><xref rid="FN3" ref-type="author-notes">74</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada</aff><aff id="A2"><label>2</label>Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada</aff><aff id="A3"><label>3</label>Department of Medical Biophysics, University of Toronto, Toronto, ON M5G0A4, Canada</aff><aff id="A4"><label>4</label>Department of Molecular Genetics, University of Toronto, Toronto, ON M5G0A4, Canada</aff><aff id="A5"><label>5</label>Department of Computer Science, University of Toronto, Toronto, ON M5G0A4, Canada</aff><aff id="A6"><label>6</label>Department of Surgery, University of Toronto, Toronto, ON M5G0A4, Canada</aff><aff id="A7"><label>7</label>Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A8"><label>8</label>Division of Neurosurgery, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A9"><label>9</label>Division of Pathology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A10"><label>10</label>Program in Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A11"><label>11</label>Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A12"><label>12</label>Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A13"><label>13</label>Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada</aff><aff id="A14"><label>14</label>Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G1L7, Canada</aff><aff id="A15"><label>15</label>Department of Pathology, Groupement Hospitalier Est, CHU de Lyon, Lyon-Bron 69677, France</aff><aff id="A16"><label>16</label>Department of Pediatrics, McGill University, Montreal, QC H3Z2Z3, Canada</aff><aff id="A17"><label>17</label>Department of Human Genetics, McGill University, Montreal, QC H3Z2Z3, Canada</aff><aff id="A18"><label>18</label>Department of Pathology, McGill University, Montreal, QC H3Z2Z3, Canada</aff><aff id="A19"><label>19</label>Genome Quebec Innovation Centre, McGill University, Montreal, QC H3A1A4, Canada</aff><aff id="A20"><label>20</label>Division of Pediatric Hematology/Oncology, Alberta Children’s Hospital, AB T3B6A8, Canada</aff><aff id="A21"><label>21</label>Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB T2N1N4, Canada</aff><aff id="A22"><label>22</label>Department of Neurosurgery, Asan Medical Center, Seoul 138-736, Korea</aff><aff id="A23"><label>23</label>Division of Anatomic Pathology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</aff><aff id="A24"><label>24</label>Division of Hematology and Oncology, Children’s and Women’s Health Centre of B.C, University of British Columbia, Vancouver, BC V6H3N1, Canada</aff><aff id="A25"><label>25</label>Department of Pathology & Laboratory Medicine, University of British Columbia, V6T1Z3, Canada</aff><aff id="A26"><label>26</label>Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China</aff><aff id="A27"><label>27</label>Laboratory Medicine and Pathology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</aff><aff id="A28"><label>28</label>Division of Neurosurgery, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</aff><aff id="A29"><label>29</label>Division of Pediatric Hematology/Oncology, Stollery Children’s Hospital, University of Alberta, Edmonton, AB T2W3N2, Canada</aff><aff id="A30"><label>30</label>Divison of Pathology, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</aff><aff id="A31"><label>31</label>Department of Neurosurgery, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon 1649-035, Portugal</aff><aff id="A32"><label>32</label>Cytometry and Cytogenetic Laboratory, CIPM, Portuguese Cancer Institute, Lisbon 1099-023, Portugal</aff><aff id="A33"><label>33</label>Division of Oncology, Department of Cancer and Blood Diseases, Cincinnati Children’s Hospital, Cincinnati, OH 45229, USA</aff><aff id="A34"><label>34</label>Department of Pediatrics, University of Colorado, Denver, CO 80045, USA</aff><aff id="A35"><label>35</label>Oncology Service, Children’s Health Queensland Hospital; University of Queensland Diamantina Institute, Brisbane, QLD 4102, Australia</aff><aff id="A36"><label>36</label>Research Institute of Health Development Strategies, Fudan University, Shanghai 200032, China</aff><aff id="A37"><label>37</label>Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital, Seoul 03080, Korea</aff><aff id="A38"><label>38</label>Royal Children’s Hospital, Murdoch Children’s Research Institute, Melbourne, VIC 3052, Australia</aff><aff id="A39"><label>39</label>Children’s Cancer Research Unit, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia</aff><aff id="A40"><label>40</label>Department of Neurosurgery, University of Debrecen, Debrecen 4032, Hungary</aff><aff id="A41"><label>41</label>Second Department of Pediatrics, Semmelweis University, Budapest 1094, Hungary</aff><aff id="A42"><label>42</label>Department of Histopathology, University of Szeged, Szeged 6720, Hungary</aff><aff id="A43"><label>43</label>Department of Pediatrics, Division of Hematology-Oncology, Université de Montréal/CHU Sainte-Justine, Montreal, QC H3T1C5, Canada</aff><aff id="A44"><label>44</label>Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0631, USA</aff><aff id="A45"><label>45</label>Department of Oncology, Children’s National Medical Center, Washington, DC 20010, USA</aff><aff id="A46"><label>46</label>Division of Neuro-Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</aff><aff id="A47"><label>47</label>Department of Medical Research, Taipei Veterans General Hospital and National Yang-Ming University, Taipei 112, Taiwan</aff><aff id="A48"><label>48</label>Department of Neurosurgery, Kumamoto University, Kumamoto 860-8556, Japan</aff><aff id="A49"><label>49</label>Department of Pediatric Hematology Oncology, Children’s Medical Center of Israel, Petach Tikva 49202, Isreal</aff><aff id="A50"><label>50</label>Department of Pediatric Hematology-Oncology, Hadassah Hebrew University Medical Center, Jerusalem 91120, Israel</aff><aff id="A51"><label>51</label>Department of Neurosurgery, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA</aff><aff id="A52"><label>52</label>Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, Japan</aff><aff id="A53"><label>53</label>Department of Pediatrics, McMaster University, Hamilton, ON L8S4K1, Canada</aff><aff id="A54"><label>54</label>Department of Pediatrics, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</aff><aff id="A55"><label>55</label>Pathology and Laboratory Medicine, Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON K1H8L1, Canada</aff><aff id="A56"><label>56</label>Division of Pediatric Hematology/Oncology, Children’s Hospital, London Health Sciences Center, London, ON N6A5A5, Canada</aff><aff id="A57"><label>57</label>Department of Pathology and Laboratory Medicine, Children’s Hospital of Western Ontario, University of Western Ontario, London, ON N6A5W9, Canada</aff><aff id="A58"><label>58</label>Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada</aff><aff id="A59"><label>59</label>Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10300, Thailand</aff><aff id="A60"><label>60</label>Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand</aff><aff id="A61"><label>61</label>Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG72RD, England</aff><aff id="A62"><label>62</label>Division of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA</aff><aff id="A63"><label>63</label>Department of Pediatrics (Hematology/Oncology), University of California, San Francisco, San Francisco, CA 94143-0112, USA</aff><aff id="A64"><label>64</label>Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA</aff><aff id="A65"><label>65</label>Department of Pediatric Hematology and Oncology, University of Alabama, Birmingham, AL 35233, USA</aff><aff id="A66"><label>66</label>Department of Neurosurgery, University of Alabama, Birmingham, AL 35233, USA</aff><aff id="A67"><label>67</label>Department of Neuroradiology, University of Würzburg, Würzburg 97070, Germany</aff><aff id="A68"><label>68</label>Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</aff><aff id="A69"><label>69</label>Department of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany</aff><aff id="A70"><label>70</label>Institute for Neuropathology, University of Bonn Medical Center, Bonn 53105, Germany</aff><aff id="A71"><label>71</label>Department of Pathology & Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA</aff><aff id="A72"><label>72</label>Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA</aff><author-notes><corresp id="FN1"><label>*</label>Correspondence: <email>ddecarv@uhnresearch.ca</email> (D.D.D.C.), <email>james.rutka@sickkids.ca</email> (J.T.R.), <email>nada.jabado@mcgill.ca</email> (N.J.), <email>annie.huang@sickkids.ca</email> (A.H.)</corresp><fn id="FN2"><label>73</label><p>Co-first author</p></fn><fn id="FN3"><label>74</label><p>Lead Contact</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>5</day><month>5</month><year>2017</year></pub-date><pub-date pub-type="ppub"><day>12</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>7</month><year>2017</year></pub-date><volume>30</volume><issue>6</issue><fpage>891</fpage><lpage>908</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.ccell.2016.11.003</pmc-comment>
<abstract id="Abs1"><title>SUMMARY</title><p id="P1">We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.</p></abstract><abstract abstract-type="graphical" id="Abs2"><title>In Brief</title><p id="P2">Torchia et al. show that atypical teratoid rhabdoid tumors (ATRTs) are composed of three epigenetic subgroups that correlate with differential cellular responses to a panel of signaling and epigenetic inhibitors. Specifically, dasatinib and nilotinib are identified as promising therapeutics for group 2 ATRTs.</p><p id="P3"><graphic xlink:href="nihms870627u1.jpg" position="anchor" orientation="portrait"></graphic></p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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