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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson’s disease: a large-scale international study</title>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
</author>
<author><name sortKey="Nelson, Lorene M" sort="Nelson, Lorene M" uniqKey="Nelson L" first="Lorene M" last="Nelson">Lorene M. Nelson</name>
</author>
<author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P A" last="Ioannidis">John P A. Ioannidis</name>
</author>
<author><name sortKey="Fiske, Brian K" sort="Fiske, Brian K" uniqKey="Fiske B" first="Brian K" last="Fiske">Brian K. Fiske</name>
</author>
<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
</author>
<author><name sortKey="Belin, Andrea Carmine" sort="Belin, Andrea Carmine" uniqKey="Belin A" first="Andrea Carmine" last="Belin">Andrea Carmine Belin</name>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A" last="Factor">Stewart A. Factor</name>
</author>
<author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M" last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
</author>
<author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S" last="Higgins">Donald S. Higgins</name>
</author>
<author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
</author>
<author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
</author>
<author><name sortKey="Mayeux, Richard P" sort="Mayeux, Richard P" uniqKey="Mayeux R" first="Richard P" last="Mayeux">Richard P. Mayeux</name>
</author>
<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</author>
<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
</author>
<author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
</author>
<author><name sortKey="Van Den Eeden, Stephen K" sort="Van Den Eeden, Stephen K" uniqKey="Van Den Eeden S" first="Stephen K" last="Van Den Eeden">Stephen K. Van Den Eeden</name>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name>
</author>
<author><name sortKey="Dehem, Marie" sort="Dehem, Marie" uniqKey="Dehem M" first="Marie" last="Dehem">Marie Dehem</name>
</author>
<author><name sortKey="Montimurro, Jennifer S" sort="Montimurro, Jennifer S" uniqKey="Montimurro J" first="Jennifer S" last="Montimurro">Jennifer S. Montimurro</name>
</author>
<author><name sortKey="Southwick, Audrey" sort="Southwick, Audrey" uniqKey="Southwick A" first="Audrey" last="Southwick">Audrey Southwick</name>
</author>
<author><name sortKey="Myers, Richard M" sort="Myers, Richard M" uniqKey="Myers R" first="Richard M" last="Myers">Richard M. Myers</name>
</author>
<author><name sortKey="Trikalinos, Thomas A" sort="Trikalinos, Thomas A" uniqKey="Trikalinos T" first="Thomas A" last="Trikalinos">Thomas A. Trikalinos</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17052658</idno>
<idno type="pmc">3636768</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636768</idno>
<idno type="RBID">PMC:3636768</idno>
<idno type="doi">10.1016/S1474-4422(06)70579-8</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">001E05</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E05</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson’s disease: a large-scale international study</title>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
</author>
<author><name sortKey="Nelson, Lorene M" sort="Nelson, Lorene M" uniqKey="Nelson L" first="Lorene M" last="Nelson">Lorene M. Nelson</name>
</author>
<author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P A" last="Ioannidis">John P A. Ioannidis</name>
</author>
<author><name sortKey="Fiske, Brian K" sort="Fiske, Brian K" uniqKey="Fiske B" first="Brian K" last="Fiske">Brian K. Fiske</name>
</author>
<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
</author>
<author><name sortKey="Belin, Andrea Carmine" sort="Belin, Andrea Carmine" uniqKey="Belin A" first="Andrea Carmine" last="Belin">Andrea Carmine Belin</name>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A" last="Factor">Stewart A. Factor</name>
</author>
<author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M" last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
</author>
<author><name sortKey="Higgins, Donald S" sort="Higgins, Donald S" uniqKey="Higgins D" first="Donald S" last="Higgins">Donald S. Higgins</name>
</author>
<author><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
</author>
<author><name sortKey="Marder, Karen S" sort="Marder, Karen S" uniqKey="Marder K" first="Karen S" last="Marder">Karen S. Marder</name>
</author>
<author><name sortKey="Mayeux, Richard P" sort="Mayeux, Richard P" uniqKey="Mayeux R" first="Richard P" last="Mayeux">Richard P. Mayeux</name>
</author>
<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D" last="Mellick">George D. Mellick</name>
</author>
<author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John G" last="Nutt">John G. Nutt</name>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
</author>
<author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
</author>
<author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name>
</author>
<author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name>
</author>
<author><name sortKey="Van Den Eeden, Stephen K" sort="Van Den Eeden, Stephen K" uniqKey="Van Den Eeden S" first="Stephen K" last="Van Den Eeden">Stephen K. Van Den Eeden</name>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name>
</author>
<author><name sortKey="Dehem, Marie" sort="Dehem, Marie" uniqKey="Dehem M" first="Marie" last="Dehem">Marie Dehem</name>
</author>
<author><name sortKey="Montimurro, Jennifer S" sort="Montimurro, Jennifer S" uniqKey="Montimurro J" first="Jennifer S" last="Montimurro">Jennifer S. Montimurro</name>
</author>
<author><name sortKey="Southwick, Audrey" sort="Southwick, Audrey" uniqKey="Southwick A" first="Audrey" last="Southwick">Audrey Southwick</name>
</author>
<author><name sortKey="Myers, Richard M" sort="Myers, Richard M" uniqKey="Myers R" first="Richard M" last="Myers">Richard M. Myers</name>
</author>
<author><name sortKey="Trikalinos, Thomas A" sort="Trikalinos, Thomas A" uniqKey="Trikalinos T" first="Thomas A" last="Trikalinos">Thomas A. Trikalinos</name>
</author>
</analytic>
<series><title level="j">Lancet neurology</title>
<idno type="ISSN">1474-4422</idno>
<idno type="eISSN">1474-4465</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Summary</title>
<sec id="S1"><title>Background</title>
<p id="P1">A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson’s disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Investigators from three Michael J Fox Foundation for Parkinson’s Research-funded genetics consortia—comprising 14 teams—contributed DNA samples from 5526 patients with Parkinson’s disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies.</p>
</sec>
<sec id="S3"><title>Findings</title>
<p id="P3">In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0·89 to 1·09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0·95 to 1.08); there was little heterogeneity except for SNP rs7520966.</p>
</sec>
<sec id="S4"><title>Interpretation</title>
<p id="P4">Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson’s disease.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101139309</journal-id>
<journal-id journal-id-type="pubmed-jr-id">30413</journal-id>
<journal-id journal-id-type="nlm-ta">Lancet Neurol</journal-id>
<journal-id journal-id-type="iso-abbrev">Lancet Neurol</journal-id>
<journal-title-group><journal-title>Lancet neurology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1474-4422</issn>
<issn pub-type="epub">1474-4465</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17052658</article-id>
<article-id pub-id-type="pmc">3636768</article-id>
<article-id pub-id-type="doi">10.1016/S1474-4422(06)70579-8</article-id>
<article-id pub-id-type="manuscript">NIHMS457053</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson’s disease: a large-scale international study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Elbaz</surname>
<given-names>Alexis</given-names>
</name>
<degrees>MD</degrees>
<aff id="A1">INSERM, Unit 708, Paris, France</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Nelson</surname>
<given-names>Lorene M</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A2">Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Payami</surname>
<given-names>Haydeh</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A3">Wadsworth Center, New York State Department of Health, Albany, NY, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Ioannidis</surname>
<given-names>John P A</given-names>
</name>
<degrees>MD</degrees>
<aff id="A4">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Fiske</surname>
<given-names>Brian K</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A5">The Michael J Fox Foundation for Parkinson’s Research, New York, NY, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Annesi</surname>
<given-names>Grazia</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A6">Institute of Neurological Sciences, National Research Council, Mangone, Italy</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Belin</surname>
<given-names>Andrea Carmine</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A7">Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Factor</surname>
<given-names>Stewart A</given-names>
</name>
<degrees>DO</degrees>
<aff id="A8">Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Ferrarese</surname>
<given-names>Carlo</given-names>
</name>
<degrees>MD</degrees>
<aff id="A9">Department of Neuroscience-Section of Neurology, University of Milano-Bicocca Ospedale San Gerardo, Monza, Italy</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Hadjigeorgiou</surname>
<given-names>Georgios M</given-names>
</name>
<degrees>MD</degrees>
<aff id="A10">University of Thessaly, School of Medicine, Larissa, Greece</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Higgins</surname>
<given-names>Donald S</given-names>
</name>
<degrees>MD</degrees>
<aff id="A11">Parkinson’s Disease and Movement Disorder Clinic, Albany Medical Center, Albany, NY, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Kawakami</surname>
<given-names>Hideshi</given-names>
</name>
<degrees>MD</degrees>
<aff id="A12">Department of Epidemiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Krüger</surname>
<given-names>Rejko</given-names>
</name>
<degrees>MD</degrees>
<aff id="A13">Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Marder</surname>
<given-names>Karen S</given-names>
</name>
<degrees>MD</degrees>
<aff id="A14">The Gertrude H Sergivesky Center, New York, NY, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Mayeux</surname>
<given-names>Richard P</given-names>
</name>
<degrees>MD</degrees>
<aff id="A15">The Gertrude H Sergivesky Center, New York, NY, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Mellick</surname>
<given-names>George D</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A16">Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Australia</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Nutt</surname>
<given-names>John G</given-names>
</name>
<degrees>MD</degrees>
<aff id="A17">Department of Neurology, Oregon Health & Science University, Portland, OR, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Ritz</surname>
<given-names>Beate</given-names>
</name>
<degrees>MD</degrees>
<aff id="A18">Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Samii</surname>
<given-names>Ali</given-names>
</name>
<degrees>MD</degrees>
<aff id="A19">Parkinson Disease Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Tanner</surname>
<given-names>Caroline M</given-names>
</name>
<degrees>MD</degrees>
<aff id="A20">The Parkinson’s Institute, Sunnyvale, CA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Van Broeckhoven</surname>
<given-names>Christine</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A21">Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Antwerpen, Belgium</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Van Den Eeden</surname>
<given-names>Stephen K</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A22">Division of Research, Kaiser Foundation Research Institute, Oakland, CA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Wirdefeldt</surname>
<given-names>Karin</given-names>
</name>
<degrees>MD</degrees>
<aff id="A23">Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Zabetian</surname>
<given-names>Cyrus P</given-names>
</name>
<degrees>MD</degrees>
<aff id="A24">Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington, Seattle, WA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Dehem</surname>
<given-names>Marie</given-names>
</name>
<degrees>PhD</degrees>
<aff id="A25">Genoscreen, Lille, France</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Montimurro</surname>
<given-names>Jennifer S</given-names>
</name>
<degrees>BS</degrees>
<aff id="A26">Wadsworth Center, New York State Department of Health, Albany, NY, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Southwick</surname>
<given-names>Audrey</given-names>
</name>
<aff id="A27">Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Myers</surname>
<given-names>Richard M</given-names>
</name>
<aff id="A28">Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Trikalinos</surname>
<given-names>Thomas A</given-names>
</name>
<degrees>MD</degrees>
<aff id="A29">Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece</aff>
</contrib>
</contrib-group>
<author-notes><corresp id="CR1">Correspondence to: Brian K Fiske, The Michael J Fox Foundation for Parkinson’s Research, Grand Central Station, PO Box 4777, New York, NY 10163, USA, <email>bfiske@michaeljfox.org</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>4</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>11</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>26</day>
<month>4</month>
<year>2013</year>
</pub-date>
<volume>5</volume>
<issue>11</issue>
<fpage>917</fpage>
<lpage>923</lpage>
<abstract><title>Summary</title>
<sec id="S1"><title>Background</title>
<p id="P1">A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson’s disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Investigators from three Michael J Fox Foundation for Parkinson’s Research-funded genetics consortia—comprising 14 teams—contributed DNA samples from 5526 patients with Parkinson’s disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies.</p>
</sec>
<sec id="S3"><title>Findings</title>
<p id="P3">In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0·89 to 1·09). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0·95 to 1.08); there was little heterogeneity except for SNP rs7520966.</p>
</sec>
<sec id="S4"><title>Interpretation</title>
<p id="P4">Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson’s disease.</p>
</sec>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Environmental Health Sciences : NIEHS</funding-source>
<award-id>R01 ES010544 || ES</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Environmental Health Sciences : NIEHS</funding-source>
<award-id>P01 ES016732 || ES</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
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