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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New gene functions in megakaryopoiesis and platelet formation</title><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A1">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Cvejic, Ana" sort="Cvejic, Ana" uniqKey="Cvejic A" first="Ana" last="Cvejic">Ana Cvejic</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation><nlm:aff id="A4">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455-0354, USA</nlm:aff></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="A6">San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Serbanovic Canic, Jovana" sort="Serbanovic Canic, Jovana" uniqKey="Serbanovic Canic J" first="Jovana" last="Serbanovic-Canic">Jovana Serbanovic-Canic</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Elling, Ulrich" sort="Elling, Ulrich" uniqKey="Elling U" first="Ulrich" last="Elling">Ulrich Elling</name><affiliation><nlm:aff id="A7">IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name><affiliation><nlm:aff id="A8">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Labrune, Yann" sort="Labrune, Yann" uniqKey="Labrune Y" first="Yann" last="Labrune">Yann Labrune</name><affiliation><nlm:aff id="A10">CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A13">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Okada, Yukinori" sort="Okada, Yukinori" uniqKey="Okada Y" first="Yukinori" last="Okada">Yukinori Okada</name><affiliation><nlm:aff id="A14">Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A102">University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="A17">Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A18">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A19">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A20">Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195-0001, USA</nlm:aff></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation><nlm:aff id="A21">Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation><nlm:aff id="A22">Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A25">Interdisciplinary Centre for Clinical Research, University of Leipzig, Inselstr. 22, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Estonian Biocenter, Riia 23b, 51010, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><affiliation><nlm:aff id="A31">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Nutrition-Dietetics, Harokopio University, Athens 17671, Greece</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="A34">Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Schoot, C Ellen" sort="Van Der Schoot, C Ellen" uniqKey="Van Der Schoot C" first="C. Ellen" last="Van Der Schoot">C. Ellen Van Der Schoot</name><affiliation><nlm:aff id="A37">Department of Experimental Immunohaematology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Allayee, Hooman" sort="Allayee, Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name><affiliation><nlm:aff id="A31">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation></author><author><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018Villejuif, 94807France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">University Paris Sud 11,UMRS 1018, Villejuif, 94807 France</nlm:aff></affiliation></author><author><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><affiliation><nlm:aff id="A40">Service de Médecine Interne, CHUV, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation><nlm:aff id="A41">Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, mmc 303, 420 Delaware St SE, Minneapolis, Minnesota 55455, USA</nlm:aff></affiliation></author><author><name sortKey="Baumeister, Sebastian E" sort="Baumeister, Sebastian E" uniqKey="Baumeister S" first="Sebastian E." last="Baumeister">Sebastian E. Baumeister</name><affiliation><nlm:aff id="A42">Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Biino, Ginevra" sort="Biino, Ginevra" uniqKey="Biino G" first="Ginevra" last="Biino">Ginevra Biino</name><affiliation><nlm:aff id="A34">Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Shardna Life Sciences, Loc. Piscinamanna 09010 Pula (CA), Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Institute of Molecular Genetics-CNR Via Abbiategrasso 207, 27100 Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Bomba, Lorenzo" sort="Bomba, Lorenzo" uniqKey="Bomba L" first="Lorenzo" last="Bomba">Lorenzo Bomba</name><affiliation><nlm:aff id="A45">Istituto di Zootecnica, Universita’ Cattolica del Sacro Cuore sede Piacenza, via Emilia Parmense 84, 29122 Piacenza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><affiliation><nlm:aff id="A10">CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="François" last="Cambien">François Cambien</name><affiliation><nlm:aff id="A46">INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6) and Medical School, 91 Bd de l’Hôpital, 75013 Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A19">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="D Damo, Pio" sort="D Damo, Pio" uniqKey="D Damo P" first="Pio" last="D Damo">Pio D Damo</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A102">University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</nlm:aff></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation><nlm:aff id="A12">Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A47">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A19">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A49">MRC-HPA Centre for Environment and Health, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A50">Universität zu Lübeck, Medizinische Klinik 2, Lübeck Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Nordic Center of Cardiovascular Research, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><nlm:aff id="A51">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Falchi, Mario" sort="Falchi, Mario" uniqKey="Falchi M" first="Mario" last="Falchi">Mario Falchi</name><affiliation><nlm:aff id="A52">Department of Genomics of Common Disease, School of Public Health, Imperial College London, The Commonwealth Building, The Hammersmith Hospital, Du Care Road, London W12 ONN, UK</nlm:aff></affiliation></author><author><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name><affiliation><nlm:aff id="A41">Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, mmc 303, 420 Delaware St SE, Minneapolis, Minnesota 55455, USA</nlm:aff></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><nlm:aff id="A4">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455-0354, USA</nlm:aff></affiliation></author><author><name sortKey="Frazer, Ian H" sort="Frazer, Ian H" uniqKey="Frazer I" first="Ian H." last="Frazer">Ian H. Frazer</name><affiliation><nlm:aff id="A53">The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A54">Department of Medicine, Boston University, Boston, Massachusetts 02118, USA.</nlm:aff></affiliation></author><author><name sortKey="Hammond, Chris" sort="Hammond, Chris" uniqKey="Hammond C" first="Chris" last="Hammond">Chris Hammond</name><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A55">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R." last="Heckbert">Susan R. Heckbert</name><affiliation><nlm:aff id="A56">Department of Epidemiology, University of Washington, Seattle, Washington 98195-7236, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A58">Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><affiliation><nlm:aff id="A59">Department of Medical Genetics, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A60">Unit for Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation><nlm:aff id="A61">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Clinical Gerontology Unit, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Kuhnel, Brigitte" sort="Kuhnel, Brigitte" uniqKey="Kuhnel B" first="Brigitte" last="Kühnel">Brigitte Kühnel</name><affiliation><nlm:aff id="A1">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kyrtsonis, Marie Christine" sort="Kyrtsonis, Marie Christine" uniqKey="Kyrtsonis M" first="Marie-Christine" last="Kyrtsonis">Marie-Christine Kyrtsonis</name><affiliation><nlm:aff id="A63">First Department of Propedeutic Internal Medicine and Hematology Department, National and Kapodistrian University of Athens Medical School, Laikon General Hospital,Athens 11727, Greece</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A64">Oxford Centre for Diabetes,Endocrinologyand Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation><nlm:aff id="A65">Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Maschio, Andrea" sort="Maschio, Andrea" uniqKey="Maschio A" first="Andrea" last="Maschio">Andrea Maschio</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A65">Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA</nlm:aff></affiliation></author><author><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation><nlm:aff id="A67">Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A69">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation><nlm:aff id="A70">Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University Kiel, 24105 Kiel, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Popgen Biobank, University Clinic Schleswig-Holstein, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A72">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A55">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">National Institute for Health and Welfare, Aapistie 1, Oulu 90220, Finland</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A22">Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Pullat, Janne" sort="Pullat, Janne" uniqKey="Pullat J" first="Janne" last="Pullat">Janne Pullat</name><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A51">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A75">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="A17">Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A76">Institute of Diagnostics, Clinical Chemistry, University of Oulu, Box 5000Y, University of Oulu, Oulu 90014, Finland</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="A6">San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A8">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A78">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224-6825, USA</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="A21">Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name><affiliation><nlm:aff id="A50">Universität zu Lübeck, Medizinische Klinik 2, Lübeck Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Nordic Center of Cardiovascular Research, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation><nlm:aff id="A79">Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name><affiliation><nlm:aff id="A56">Department of Epidemiology, University of Washington, Seattle, Washington 98195-7236, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, Washington 98108, USA</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A72">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Geriatric Medicine Unit, The University of Edinburgh, Royal Victoria, Craigleith Road, Edinburgh EH4 2DN, UK</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A82">Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation><nlm:aff id="A14">Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</nlm:aff></affiliation></author><author><name sortKey="Tang, W H Wilson" sort="Tang, W H Wilson" uniqKey="Tang W" first="W. H. Wilson" last="Tang">W. H. Wilson Tang</name><affiliation><nlm:aff id="A83">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name><affiliation><nlm:aff id="A75">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation><nlm:aff id="A85">Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, Edinburgh EH4 2XU, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A86">The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin Midlothian EH25 9RG, UK</nlm:aff></affiliation></author><author><name sortKey="Thein, Swee Lay" sort="Thein, Swee Lay" uniqKey="Thein S" first="Swee Lay" last="Thein">Swee Lay Thein</name><affiliation><nlm:aff id="A87">Department of Molecular Haematology, King’s College London, 125 Coldharbour Lane, London SE5 9NU, UK</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A82">Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="A18">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="A47">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Wiggins, Kerri L" sort="Wiggins, Kerri L" uniqKey="Wiggins K" first="Kerri L." last="Wiggins">Kerri L. Wiggins</name><affiliation><nlm:aff id="A20">Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195-0001, USA</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yang, Tsun Po" sort="Yang, Tsun Po" uniqKey="Yang T" first="Tsun-Po" last="Yang">Tsun-Po Yang</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A89">Department of Physiatrics, Lapland Central Hospital, Rovaniemi, 96101, Finland</nlm:aff></affiliation></author><author><name sortKey="Bradley, John R" sort="Bradley, John R" uniqKey="Bradley J" first="John R." last="Bradley">John R. Bradley</name><affiliation><nlm:aff id="A77">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A33">Department of Nutrition-Dietetics, Harokopio University, Athens 17671, Greece</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A102">University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</nlm:aff></affiliation></author><author><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><affiliation><nlm:aff id="A83">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Estonian Biocenter, Riia 23b, 51010, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="A34">Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Shardna Life Sciences, Loc. Piscinamanna 09010 Pula (CA), Italy</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21208, USA.</nlm:aff></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation><nlm:aff id="A91">Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zwaginga, Jaap Jan" sort="Zwaginga, Jaap Jan" uniqKey="Zwaginga J" first="Jaap-Jan" last="Zwaginga">Jaap-Jan Zwaginga</name><affiliation><nlm:aff id="A92">Sanquin Research Leiden, Jon J. van Rood Center for Clinical Transfusion research, and the Department of Immuno-hematology and Blood Transfusion, Leiden University Medical Center, 2333 Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation><nlm:aff id="A21">Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A10">CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Genomics of Common Disease, School of Public Health, Imperial College London, The Commonwealth Building, The Hammersmith Hospital, Du Care Road, London W12 ONN, UK</nlm:aff></affiliation></author><author><name sortKey="Ganesh, Santhi K" sort="Ganesh, Santhi K" uniqKey="Ganesh S" first="Santhi K." last="Ganesh">Santhi K. Ganesh</name><affiliation><nlm:aff id="A93">Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Institute of Health Sciences, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A95">National Institute for Health and Welfare, Biocenter Oulu, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A48">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A57">Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Akkerman, Jan Willem N" sort="Akkerman, Jan Willem N" uniqKey="Akkerman J" first="Jan-Willem N." last="Akkerman">Jan-Willem N. Akkerman</name><affiliation><nlm:aff id="A97">Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="A17">Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:aff id="A98">Institute for Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Jupe, Steve" sort="Jupe, Steve" uniqKey="Jupe S" first="Steve" last="Jupe">Steve Jupe</name><affiliation><nlm:aff id="A99">Proteomics Services, EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Kamatani, Naoyuki" sort="Kamatani, Naoyuki" uniqKey="Kamatani N" first="Naoyuki" last="Kamatani">Naoyuki Kamatani</name><affiliation><nlm:aff id="A14">Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</nlm:aff></affiliation></author><author><name sortKey="Khadake, Jyoti" sort="Khadake, Jyoti" uniqKey="Khadake J" first="Jyoti" last="Khadake">Jyoti Khadake</name><affiliation><nlm:aff id="A99">Proteomics Services, EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A79">Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name><affiliation><nlm:aff id="A7">IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A64">Oxford Centre for Diabetes,Endocrinologyand Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Stemple, Derek" sort="Stemple, Derek" uniqKey="Stemple D" first="Derek" last="Stemple">Derek Stemple</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="A6">San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Institute of Molecular Genetics-CNR Via Abbiategrasso 207, 27100 Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Wernisch, Lorenz" sort="Wernisch, Lorenz" uniqKey="Wernisch L" first="Lorenz" last="Wernisch">Lorenz Wernisch</name><affiliation><nlm:aff id="A100">MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A22">Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A100">MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22139419</idno><idno type="pmc">3335296</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335296</idno><idno type="RBID">PMC:3335296</idno><idno type="doi">10.1038/nature10659</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001D31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">New gene functions in megakaryopoiesis and platelet formation</title><author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name><affiliation><nlm:aff id="A1">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Radhakrishnan, Aparna" sort="Radhakrishnan, Aparna" uniqKey="Radhakrishnan A" first="Aparna" last="Radhakrishnan">Aparna Radhakrishnan</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Cvejic, Ana" sort="Cvejic, Ana" uniqKey="Cvejic A" first="Ana" last="Cvejic">Ana Cvejic</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation><nlm:aff id="A4">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455-0354, USA</nlm:aff></affiliation></author><author><name sortKey="Porcu, Eleonora" sort="Porcu, Eleonora" uniqKey="Porcu E" first="Eleonora" last="Porcu">Eleonora Porcu</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name><affiliation><nlm:aff id="A6">San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Serbanovic Canic, Jovana" sort="Serbanovic Canic, Jovana" uniqKey="Serbanovic Canic J" first="Jovana" last="Serbanovic-Canic">Jovana Serbanovic-Canic</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Elling, Ulrich" sort="Elling, Ulrich" uniqKey="Elling U" first="Ulrich" last="Elling">Ulrich Elling</name><affiliation><nlm:aff id="A7">IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name><affiliation><nlm:aff id="A8">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Labrune, Yann" sort="Labrune, Yann" uniqKey="Labrune Y" first="Yann" last="Labrune">Yann Labrune</name><affiliation><nlm:aff id="A10">CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M." last="Lopez">Lorna M. Lopez</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name><affiliation><nlm:aff id="A13">Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Meacham, Stuart" sort="Meacham, Stuart" uniqKey="Meacham S" first="Stuart" last="Meacham">Stuart Meacham</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Okada, Yukinori" sort="Okada, Yukinori" uniqKey="Okada Y" first="Yukinori" last="Okada">Yukinori Okada</name><affiliation><nlm:aff id="A14">Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Nicola" sort="Pirastu, Nicola" uniqKey="Pirastu N" first="Nicola" last="Pirastu">Nicola Pirastu</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A102">University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</nlm:aff></affiliation></author><author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name><affiliation><nlm:aff id="A17">Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:aff id="A18">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Voss, Katrin" sort="Voss, Katrin" uniqKey="Voss K" first="Katrin" last="Voss">Katrin Voss</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Zhang, Weihua" sort="Zhang, Weihua" uniqKey="Zhang W" first="Weihua" last="Zhang">Weihua Zhang</name><affiliation><nlm:aff id="A19">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Ramirez Solis, Ramiro" sort="Ramirez Solis, Ramiro" uniqKey="Ramirez Solis R" first="Ramiro" last="Ramirez-Solis">Ramiro Ramirez-Solis</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation><nlm:aff id="A20">Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195-0001, USA</nlm:aff></affiliation></author><author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name><affiliation><nlm:aff id="A21">Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Gogele, Martin" sort="Gogele, Martin" uniqKey="Gogele M" first="Martin" last="Gögele">Martin Gögele</name><affiliation><nlm:aff id="A22">Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Hottenga, Jouke Jan" sort="Hottenga, Jouke Jan" uniqKey="Hottenga J" first="Jouke-Jan" last="Hottenga">Jouke-Jan Hottenga</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name><affiliation><nlm:aff id="A25">Interdisciplinary Centre for Clinical Research, University of Leipzig, Inselstr. 22, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="O Eilly, Paul F" sort="O Eilly, Paul F" uniqKey="O Eilly P" first="Paul F." last="O Eilly">Paul F. O Eilly</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Estonian Biocenter, Riia 23b, 51010, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Hartiala, Jaana" sort="Hartiala, Jaana" uniqKey="Hartiala J" first="Jaana" last="Hartiala">Jaana Hartiala</name><affiliation><nlm:aff id="A31">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation></author><author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Department of Nutrition-Dietetics, Harokopio University, Athens 17671, Greece</nlm:aff></affiliation></author><author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name><affiliation><nlm:aff id="A34">Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</nlm:aff></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation></author><author><name sortKey="Stephens, Jonathan" sort="Stephens, Jonathan" uniqKey="Stephens J" first="Jonathan" last="Stephens">Jonathan Stephens</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Van Der Schoot, C Ellen" sort="Van Der Schoot, C Ellen" uniqKey="Van Der Schoot C" first="C. Ellen" last="Van Der Schoot">C. Ellen Van Der Schoot</name><affiliation><nlm:aff id="A37">Department of Experimental Immunohaematology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Allayee, Hooman" sort="Allayee, Hooman" uniqKey="Allayee H" first="Hooman" last="Allayee">Hooman Allayee</name><affiliation><nlm:aff id="A31">Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A32">Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</nlm:aff></affiliation></author><author><name sortKey="Attwood, Antony" sort="Attwood, Antony" uniqKey="Attwood A" first="Antony" last="Attwood">Antony Attwood</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:aff id="A38">Inserm, CESP Centre for research in Epidemiology and Population Health, U1018Villejuif, 94807France</nlm:aff></affiliation><affiliation><nlm:aff id="A39">University Paris Sud 11,UMRS 1018, Villejuif, 94807 France</nlm:aff></affiliation></author><author><name sortKey="Bastardot, Francois" sort="Bastardot, Francois" uniqKey="Bastardot F" first="François" last="Bastardot">François Bastardot</name><affiliation><nlm:aff id="A40">Service de Médecine Interne, CHUV, 1011 Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation><nlm:aff id="A41">Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, mmc 303, 420 Delaware St SE, Minneapolis, Minnesota 55455, USA</nlm:aff></affiliation></author><author><name sortKey="Baumeister, Sebastian E" sort="Baumeister, Sebastian E" uniqKey="Baumeister S" first="Sebastian E." last="Baumeister">Sebastian E. Baumeister</name><affiliation><nlm:aff id="A42">Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Biino, Ginevra" sort="Biino, Ginevra" uniqKey="Biino G" first="Ginevra" last="Biino">Ginevra Biino</name><affiliation><nlm:aff id="A34">Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Shardna Life Sciences, Loc. Piscinamanna 09010 Pula (CA), Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Institute of Molecular Genetics-CNR Via Abbiategrasso 207, 27100 Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Bomba, Lorenzo" sort="Bomba, Lorenzo" uniqKey="Bomba L" first="Lorenzo" last="Bomba">Lorenzo Bomba</name><affiliation><nlm:aff id="A45">Istituto di Zootecnica, Universita’ Cattolica del Sacro Cuore sede Piacenza, via Emilia Parmense 84, 29122 Piacenza, Italy</nlm:aff></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><affiliation><nlm:aff id="A10">CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</nlm:aff></affiliation></author><author><name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="François" last="Cambien">François Cambien</name><affiliation><nlm:aff id="A46">INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6) and Medical School, 91 Bd de l’Hôpital, 75013 Paris, France.</nlm:aff></affiliation></author><author><name sortKey="Chambers, John C" sort="Chambers, John C" uniqKey="Chambers J" first="John C." last="Chambers">John C. Chambers</name><affiliation><nlm:aff id="A19">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="D Damo, Pio" sort="D Damo, Pio" uniqKey="D Damo P" first="Pio" last="D Damo">Pio D Damo</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A102">University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</nlm:aff></affiliation></author><author><name sortKey="Davies, Gail" sort="Davies, Gail" uniqKey="Davies G" first="Gail" last="Davies">Gail Davies</name><affiliation><nlm:aff id="A12">Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="De Boer, Rudolf A" sort="De Boer, Rudolf A" uniqKey="De Boer R" first="Rudolf A." last="De Boer">Rudolf A. De Boer</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J. C." last="De Geus">Eco J. C. De Geus</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Doring, Angela" sort="Doring, Angela" uniqKey="Doring A" first="Angela" last="Döring">Angela Döring</name><affiliation><nlm:aff id="A47">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A48">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><nlm:aff id="A19">Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A49">MRC-HPA Centre for Environment and Health, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK</nlm:aff></affiliation></author><author><name sortKey="Erdmann, Jeanette" sort="Erdmann, Jeanette" uniqKey="Erdmann J" first="Jeanette" last="Erdmann">Jeanette Erdmann</name><affiliation><nlm:aff id="A50">Universität zu Lübeck, Medizinische Klinik 2, Lübeck Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Nordic Center of Cardiovascular Research, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><nlm:aff id="A51">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Falchi, Mario" sort="Falchi, Mario" uniqKey="Falchi M" first="Mario" last="Falchi">Mario Falchi</name><affiliation><nlm:aff id="A52">Department of Genomics of Common Disease, School of Public Health, Imperial College London, The Commonwealth Building, The Hammersmith Hospital, Du Care Road, London W12 ONN, UK</nlm:aff></affiliation></author><author><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name><affiliation><nlm:aff id="A41">Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, mmc 303, 420 Delaware St SE, Minneapolis, Minnesota 55455, USA</nlm:aff></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name><affiliation><nlm:aff id="A4">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455-0354, USA</nlm:aff></affiliation></author><author><name sortKey="Frazer, Ian H" sort="Frazer, Ian H" uniqKey="Frazer I" first="Ian H." last="Frazer">Ian H. Frazer</name><affiliation><nlm:aff id="A53">The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.</nlm:aff></affiliation></author><author><name sortKey="Gibson, Quince D" sort="Gibson, Quince D" uniqKey="Gibson Q" first="Quince D." last="Gibson">Quince D. Gibson</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation></author><author><name sortKey="Glazer, Nicole L" sort="Glazer, Nicole L" uniqKey="Glazer N" first="Nicole L." last="Glazer">Nicole L. Glazer</name><affiliation><nlm:aff id="A54">Department of Medicine, Boston University, Boston, Massachusetts 02118, USA.</nlm:aff></affiliation></author><author><name sortKey="Hammond, Chris" sort="Hammond, Chris" uniqKey="Hammond C" first="Chris" last="Hammond">Chris Hammond</name><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name><affiliation><nlm:aff id="A55">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation></author><author><name sortKey="Heckbert, Susan R" sort="Heckbert, Susan R" uniqKey="Heckbert S" first="Susan R." last="Heckbert">Susan R. Heckbert</name><affiliation><nlm:aff id="A56">Department of Epidemiology, University of Washington, Seattle, Washington 98195-7236, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation></author><author><name sortKey="Hengstenberg, Christian" sort="Hengstenberg, Christian" uniqKey="Hengstenberg C" first="Christian" last="Hengstenberg">Christian Hengstenberg</name><affiliation><nlm:aff id="A58">Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hersch, Micha" sort="Hersch, Micha" uniqKey="Hersch M" first="Micha" last="Hersch">Micha Hersch</name><affiliation><nlm:aff id="A59">Department of Medical Genetics, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name><affiliation><nlm:aff id="A60">Unit for Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Jolley, Jennifer" sort="Jolley, Jennifer" uniqKey="Jolley J" first="Jennifer" last="Jolley">Jennifer Jolley</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay Tee" last="Khaw">Kay Tee Khaw</name><affiliation><nlm:aff id="A61">Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A62">Clinical Gerontology Unit, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Kuhnel, Brigitte" sort="Kuhnel, Brigitte" uniqKey="Kuhnel B" first="Brigitte" last="Kühnel">Brigitte Kühnel</name><affiliation><nlm:aff id="A1">Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kyrtsonis, Marie Christine" sort="Kyrtsonis, Marie Christine" uniqKey="Kyrtsonis M" first="Marie-Christine" last="Kyrtsonis">Marie-Christine Kyrtsonis</name><affiliation><nlm:aff id="A63">First Department of Propedeutic Internal Medicine and Hematology Department, National and Kapodistrian University of Athens Medical School, Laikon General Hospital,Athens 11727, Greece</nlm:aff></affiliation></author><author><name sortKey="Lagou, Vasiliki" sort="Lagou, Vasiliki" uniqKey="Lagou V" first="Vasiliki" last="Lagou">Vasiliki Lagou</name><affiliation><nlm:aff id="A64">Oxford Centre for Diabetes,Endocrinologyand Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Lloyd Jones, Heather" sort="Lloyd Jones, Heather" uniqKey="Lloyd Jones H" first="Heather" last="Lloyd-Jones">Heather Lloyd-Jones</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation></author><author><name sortKey="Lumley, Thomas" sort="Lumley, Thomas" uniqKey="Lumley T" first="Thomas" last="Lumley">Thomas Lumley</name><affiliation><nlm:aff id="A65">Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA</nlm:aff></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Maschio, Andrea" sort="Maschio, Andrea" uniqKey="Maschio A" first="Andrea" last="Maschio">Andrea Maschio</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Leach, Irene Mateo" sort="Leach, Irene Mateo" uniqKey="Leach I" first="Irene Mateo" last="Leach">Irene Mateo Leach</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:aff id="A65">Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA</nlm:aff></affiliation></author><author><name sortKey="Memari, Yasin" sort="Memari, Yasin" uniqKey="Memari Y" first="Yasin" last="Memari">Yasin Memari</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Nakamura, Yusuke" sort="Nakamura, Yusuke" uniqKey="Nakamura Y" first="Yusuke" last="Nakamura">Yusuke Nakamura</name><affiliation><nlm:aff id="A67">Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</nlm:aff></affiliation></author><author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name><affiliation><nlm:aff id="A68">Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Navis, Gerjan" sort="Navis, Gerjan" uniqKey="Navis G" first="Gerjan" last="Navis">Gerjan Navis</name><affiliation><nlm:aff id="A69">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation><nlm:aff id="A70">Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University Kiel, 24105 Kiel, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A71">Popgen Biobank, University Clinic Schleswig-Holstein, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation><nlm:aff id="A72">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Porteous, David J" sort="Porteous, David J" uniqKey="Porteous D" first="David J." last="Porteous">David J. Porteous</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A73">Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK</nlm:aff></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name><affiliation><nlm:aff id="A55">Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A74">National Institute for Health and Welfare, Aapistie 1, Oulu 90220, Finland</nlm:aff></affiliation></author><author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><affiliation><nlm:aff id="A22">Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Pullat, Janne" sort="Pullat, Janne" uniqKey="Pullat J" first="Janne" last="Pullat">Janne Pullat</name><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name><affiliation><nlm:aff id="A51">MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK</nlm:aff></affiliation></author><author><name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I." last="Rotter">Jerome I. Rotter</name><affiliation><nlm:aff id="A75">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name><affiliation><nlm:aff id="A17">Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Ruokonen, Aimo" sort="Ruokonen, Aimo" uniqKey="Ruokonen A" first="Aimo" last="Ruokonen">Aimo Ruokonen</name><affiliation><nlm:aff id="A76">Institute of Diagnostics, Clinical Chemistry, University of Oulu, Box 5000Y, University of Oulu, Oulu 90014, Finland</nlm:aff></affiliation></author><author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name><affiliation><nlm:aff id="A6">San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</nlm:aff></affiliation></author><author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J." last="Samani">Nilesh J. Samani</name><affiliation><nlm:aff id="A8">Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A9">Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK</nlm:aff></affiliation></author><author><name sortKey="Sambrook, Jennifer" sort="Sambrook, Jennifer" uniqKey="Sambrook J" first="Jennifer" last="Sambrook">Jennifer Sambrook</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Schlessinger, David" sort="Schlessinger, David" uniqKey="Schlessinger D" first="David" last="Schlessinger">David Schlessinger</name><affiliation><nlm:aff id="A78">Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224-6825, USA</nlm:aff></affiliation></author><author><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name><affiliation><nlm:aff id="A21">Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Schunkert, Heribert" sort="Schunkert, Heribert" uniqKey="Schunkert H" first="Heribert" last="Schunkert">Heribert Schunkert</name><affiliation><nlm:aff id="A50">Universität zu Lübeck, Medizinische Klinik 2, Lübeck Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A101">Nordic Center of Cardiovascular Research, Lubeck, Germany</nlm:aff></affiliation></author><author><name sortKey="Scott, James" sort="Scott, James" uniqKey="Scott J" first="James" last="Scott">James Scott</name><affiliation><nlm:aff id="A79">Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name><affiliation><nlm:aff id="A56">Department of Epidemiology, University of Washington, Seattle, Washington 98195-7236, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A57">Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A80">Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, Washington 98108, USA</nlm:aff></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:aff id="A72">Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M." last="Starr">John M. Starr</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A81">Geriatric Medicine Unit, The University of Edinburgh, Royal Victoria, Craigleith Road, Edinburgh EH4 2DN, UK</nlm:aff></affiliation></author><author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name><affiliation><nlm:aff id="A82">Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation><nlm:aff id="A14">Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</nlm:aff></affiliation></author><author><name sortKey="Tang, W H Wilson" sort="Tang, W H Wilson" uniqKey="Tang W" first="W. H. Wilson" last="Tang">W. H. Wilson Tang</name><affiliation><nlm:aff id="A83">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A84">Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name><affiliation><nlm:aff id="A75">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</nlm:aff></affiliation></author><author><name sortKey="Tenesa, Albert" sort="Tenesa, Albert" uniqKey="Tenesa A" first="Albert" last="Tenesa">Albert Tenesa</name><affiliation><nlm:aff id="A85">Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, Edinburgh EH4 2XU, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A86">The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin Midlothian EH25 9RG, UK</nlm:aff></affiliation></author><author><name sortKey="Thein, Swee Lay" sort="Thein, Swee Lay" uniqKey="Thein S" first="Swee Lay" last="Thein">Swee Lay Thein</name><affiliation><nlm:aff id="A87">Department of Molecular Haematology, King’s College London, 125 Coldharbour Lane, London SE5 9NU, UK</nlm:aff></affiliation></author><author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name><affiliation><nlm:aff id="A82">Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany</nlm:aff></affiliation></author><author><name sortKey="Uda, Manuela" sort="Uda, Manuela" uniqKey="Uda M" first="Manuela" last="Uda">Manuela Uda</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation></author><author><name sortKey="Van Veldhuisen, Dirk J" sort="Van Veldhuisen, Dirk J" uniqKey="Van Veldhuisen D" first="Dirk J." last="Van Veldhuisen">Dirk J. Van Veldhuisen</name><affiliation><nlm:aff id="A36">Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Visscher, Peter M" sort="Visscher, Peter M" uniqKey="Visscher P" first="Peter M." last="Visscher">Peter M. Visscher</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:aff id="A18">Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Wichmann, H Erich" sort="Wichmann, H Erich" uniqKey="Wichmann H" first="H.-Erich" last="Wichmann">H.-Erich Wichmann</name><affiliation><nlm:aff id="A47">Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A88">Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Wiggins, Kerri L" sort="Wiggins, Kerri L" uniqKey="Wiggins K" first="Kerri L." last="Wiggins">Kerri L. Wiggins</name><affiliation><nlm:aff id="A20">Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195-0001, USA</nlm:aff></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Yang, Tsun Po" sort="Yang, Tsun Po" uniqKey="Yang T" first="Tsun-Po" last="Yang">Tsun-Po Yang</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Zitting, Paavo" sort="Zitting, Paavo" uniqKey="Zitting P" first="Paavo" last="Zitting">Paavo Zitting</name><affiliation><nlm:aff id="A89">Department of Physiatrics, Lapland Central Hospital, Rovaniemi, 96101, Finland</nlm:aff></affiliation></author><author><name sortKey="Bradley, John R" sort="Bradley, John R" uniqKey="Bradley J" first="John R." last="Bradley">John R. Bradley</name><affiliation><nlm:aff id="A77">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name><affiliation><nlm:aff id="A33">Department of Nutrition-Dietetics, Harokopio University, Athens 17671, Greece</nlm:aff></affiliation></author><author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name><affiliation><nlm:aff id="A16">Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A102">University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</nlm:aff></affiliation></author><author><name sortKey="Hazen, Stanley L" sort="Hazen, Stanley L" uniqKey="Hazen S" first="Stanley L." last="Hazen">Stanley L. Hazen</name><affiliation><nlm:aff id="A83">Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name><affiliation><nlm:aff id="A28">Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Estonian Biocenter, Riia 23b, 51010, Tartu, Estonia</nlm:aff></affiliation><affiliation><nlm:aff id="A30">Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</nlm:aff></affiliation></author><author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name><affiliation><nlm:aff id="A34">Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A43">Shardna Life Sciences, Loc. Piscinamanna 09010 Pula (CA), Italy</nlm:aff></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A35">University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A90">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21208, USA.</nlm:aff></affiliation></author><author><name sortKey="Van Pelt, L Joost" sort="Van Pelt, L Joost" uniqKey="Van Pelt L" first="L. Joost" last="Van Pelt">L. Joost Van Pelt</name><affiliation><nlm:aff id="A91">Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Zwaginga, Jaap Jan" sort="Zwaginga, Jaap Jan" uniqKey="Zwaginga J" first="Jaap-Jan" last="Zwaginga">Jaap-Jan Zwaginga</name><affiliation><nlm:aff id="A92">Sanquin Research Leiden, Jon J. van Rood Center for Clinical Transfusion research, and the Department of Immuno-hematology and Blood Transfusion, Leiden University Medical Center, 2333 Leiden, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:aff id="A23">Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><affiliation><nlm:aff id="A11">Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</nlm:aff></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation><nlm:aff id="A21">Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</nlm:aff></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:aff id="A10">CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</nlm:aff></affiliation><affiliation><nlm:aff id="A52">Department of Genomics of Common Disease, School of Public Health, Imperial College London, The Commonwealth Building, The Hammersmith Hospital, Du Care Road, London W12 ONN, UK</nlm:aff></affiliation></author><author><name sortKey="Ganesh, Santhi K" sort="Ganesh, Santhi K" uniqKey="Ganesh S" first="Santhi K." last="Ganesh">Santhi K. Ganesh</name><affiliation><nlm:aff id="A93">Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA</nlm:aff></affiliation></author><author><name sortKey="Jarvelin, Marjo Riitta" sort="Jarvelin, Marjo Riitta" uniqKey="Jarvelin M" first="Marjo-Riitta" last="Jarvelin">Marjo-Riitta Jarvelin</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A94">Institute of Health Sciences, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation><affiliation><nlm:aff id="A95">National Institute for Health and Welfare, Biocenter Oulu, University of Oulu, Aapistie 7, Oulu, 90220 Finland</nlm:aff></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation><nlm:aff id="A48">Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name><affiliation><nlm:aff id="A57">Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A96">Department of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98101-1448, USA</nlm:aff></affiliation></author><author><name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name><affiliation><nlm:aff id="A27">Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</nlm:aff></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:aff id="A24">MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Akkerman, Jan Willem N" sort="Akkerman, Jan Willem N" uniqKey="Akkerman J" first="Jan-Willem N." last="Akkerman">Jan-Willem N. Akkerman</name><affiliation><nlm:aff id="A97">Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name><affiliation><nlm:aff id="A17">Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:aff id="A98">Institute for Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</nlm:aff></affiliation></author><author><name sortKey="Jupe, Steve" sort="Jupe, Steve" uniqKey="Jupe S" first="Steve" last="Jupe">Steve Jupe</name><affiliation><nlm:aff id="A99">Proteomics Services, EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Kamatani, Naoyuki" sort="Kamatani, Naoyuki" uniqKey="Kamatani N" first="Naoyuki" last="Kamatani">Naoyuki Kamatani</name><affiliation><nlm:aff id="A14">Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</nlm:aff></affiliation></author><author><name sortKey="Khadake, Jyoti" sort="Khadake, Jyoti" uniqKey="Khadake J" first="Jyoti" last="Khadake">Jyoti Khadake</name><affiliation><nlm:aff id="A99">Proteomics Services, EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</nlm:aff></affiliation></author><author><name sortKey="Kooner, Jaspal S" sort="Kooner, Jaspal S" uniqKey="Kooner J" first="Jaspal S." last="Kooner">Jaspal S. Kooner</name><affiliation><nlm:aff id="A79">Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, London W12 0HS, UK</nlm:aff></affiliation></author><author><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name><affiliation><nlm:aff id="A7">IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</nlm:aff></affiliation></author><author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name><affiliation><nlm:aff id="A64">Oxford Centre for Diabetes,Endocrinologyand Metabolism, University of Oxford, Oxford OX3 7LJ, UK</nlm:aff></affiliation></author><author><name sortKey="Stemple, Derek" sort="Stemple, Derek" uniqKey="Stemple D" first="Derek" last="Stemple">Derek Stemple</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author><author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name><affiliation><nlm:aff id="A6">San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</nlm:aff></affiliation><affiliation><nlm:aff id="A44">Institute of Molecular Genetics-CNR Via Abbiategrasso 207, 27100 Pavia, Italy</nlm:aff></affiliation></author><author><name sortKey="Wernisch, Lorenz" sort="Wernisch, Lorenz" uniqKey="Wernisch L" first="Lorenz" last="Wernisch">Lorenz Wernisch</name><affiliation><nlm:aff id="A100">MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK</nlm:aff></affiliation></author><author><name sortKey="Sanna, Serena" sort="Sanna, Serena" uniqKey="Sanna S" first="Serena" last="Sanna">Serena Sanna</name><affiliation><nlm:aff id="A5">Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</nlm:aff></affiliation></author><author><name sortKey="Hicks, Andrew A" sort="Hicks, Andrew A" uniqKey="Hicks A" first="Andrew A." last="Hicks">Andrew A. Hicks</name><affiliation><nlm:aff id="A22">Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</nlm:aff></affiliation></author><author><name sortKey="Rendon, Augusto" sort="Rendon, Augusto" uniqKey="Rendon A" first="Augusto" last="Rendon">Augusto Rendon</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A100">MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Manuel A" sort="Ferreira, Manuel A" uniqKey="Ferreira M" first="Manuel A." last="Ferreira">Manuel A. Ferreira</name><affiliation><nlm:aff id="A66">Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</nlm:aff></affiliation></author><author><name sortKey="Ouwehand, Willem H" sort="Ouwehand, Willem H" uniqKey="Ouwehand W" first="Willem H." last="Ouwehand">Willem H. Ouwehand</name><affiliation><nlm:aff id="A2">Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A77">NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</nlm:aff></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation><nlm:aff id="A3">Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><idno type="eISSN">1476-4687</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation. These genes show megakaryocyte-specific gene expression patterns and extensive network connectivity. Using gene silencing in <italic>Danio rerio</italic> and <italic>Drosophila melanogaster</italic>, we identified 11 of the genes as novel regulators of blood cell formation. Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0410462</journal-id><journal-id journal-id-type="pubmed-jr-id">6011</journal-id><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-id journal-id-type="iso-abbrev">Nature</journal-id><journal-title-group><journal-title>Nature</journal-title></journal-title-group><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22139419</article-id><article-id pub-id-type="pmc">3335296</article-id><article-id pub-id-type="doi">10.1038/nature10659</article-id><article-id pub-id-type="manuscript">NIHMS362305</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>New gene functions in megakaryopoiesis and platelet formation</article-title></title-group><contrib-group><contrib 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Joost</given-names></name><xref ref-type="aff" rid="A91">91</xref></contrib><contrib contrib-type="author"><name><surname>Zwaginga</surname><given-names>Jaap-Jan</given-names></name><xref ref-type="aff" rid="A92">92</xref></contrib><contrib contrib-type="author"><name><surname>Boomsma</surname><given-names>Dorret I.</given-names></name><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Deary</surname><given-names>Ian J.</given-names></name><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Franke</surname><given-names>Andre</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Froguel</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Ganesh</surname><given-names>Santhi K.</given-names></name><xref ref-type="aff" rid="A93">93</xref></contrib><contrib contrib-type="author"><name><surname>Jarvelin</surname><given-names>Marjo-Riitta</given-names></name><xref ref-type="aff" rid="A26">26</xref><xref ref-type="aff" rid="A94">94</xref><xref ref-type="aff" rid="A95">95</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G.</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Meisinger</surname><given-names>Christa</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Psaty</surname><given-names>Bruce M.</given-names></name><xref ref-type="aff" rid="A57">57</xref><xref ref-type="aff" rid="A96">96</xref></contrib><contrib contrib-type="author"><name><surname>Spector</surname><given-names>Timothy D.</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Wareham</surname><given-names>Nicholas J.</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Akkerman</surname><given-names>Jan-Willem N.</given-names></name><xref ref-type="aff" rid="A97">97</xref></contrib><contrib contrib-type="author"><name><surname>Ciullo</surname><given-names>Marina</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Deloukas</surname><given-names>Panos</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Greinacher</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="A98">98</xref></contrib><contrib contrib-type="author"><name><surname>Jupe</surname><given-names>Steve</given-names></name><xref ref-type="aff" rid="A99">99</xref></contrib><contrib contrib-type="author"><name><surname>Kamatani</surname><given-names>Naoyuki</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Khadake</surname><given-names>Jyoti</given-names></name><xref ref-type="aff" rid="A99">99</xref></contrib><contrib contrib-type="author"><name><surname>Kooner</surname><given-names>Jaspal S.</given-names></name><xref ref-type="aff" rid="A79">79</xref></contrib><contrib contrib-type="author"><name><surname>Penninger</surname><given-names>Josef</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Prokopenko</surname><given-names>Inga</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Stemple</surname><given-names>Derek</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Toniolo</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Wernisch</surname><given-names>Lorenz</given-names></name><xref ref-type="aff" rid="A100">100</xref></contrib><contrib contrib-type="author"><name><surname>Sanna</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="A5">5</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Hicks</surname><given-names>Andrew A.</given-names></name><xref ref-type="aff" rid="A22">22</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Rendon</surname><given-names>Augusto</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A100">100</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ferreira</surname><given-names>Manuel A.</given-names></name><xref ref-type="aff" rid="A66">66</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ouwehand</surname><given-names>Willem H.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A77">77</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Soranzo</surname><given-names>Nicole</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</aff><aff id="A2"><label>2</label>Department of Haematology, University of Cambridge & NHS Blood and Transplant, Cambridge CB2 0PT, UK</aff><aff id="A3"><label>3</label>Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH/1SA, UK</aff><aff id="A4"><label>4</label>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota 55455-0354, USA</aff><aff id="A5"><label>5</label>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy</aff><aff id="A6"><label>6</label>San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy</aff><aff id="A7"><label>7</label>IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria</aff><aff id="A8"><label>8</label>Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK</aff><aff id="A9"><label>9</label>Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK</aff><aff id="A10"><label>10</label>CNRS-UMR-8199, Institut de Biologie de Lille, 1 Rue du Professor Calmette, BP245, 59019 Lille Cedex, France</aff><aff id="A11"><label>11</label>Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, The University of Edinburgh, Edinburgh EH8 9JZ, UK.</aff><aff id="A12"><label>12</label>Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK</aff><aff id="A13"><label>13</label>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK</aff><aff id="A14"><label>14</label>Laboratory for Statistical Analysis, RIKEN Center for Genomic Medicine, Institute ofPhysical and Chemical Research,1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan</aff><aff id="A15"><label>15</label>Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan</aff><aff id="A16"><label>16</label>Institute for Maternal and Child Health — IRCCS ‘Burlo Garofolo’ — via dell’Istria 65/1, 34137 Trieste, Italy</aff><aff id="A17"><label>17</label>Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Via P. Castellino 111, 8031 Naples, Italy</aff><aff id="A18"><label>18</label>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany</aff><aff id="A19"><label>19</label>Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, St Mary’s Campus, London W2 1PG, UK</aff><aff id="A20"><label>20</label>Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Seattle, Washington 98195-0001, USA</aff><aff id="A21"><label>21</label>Institute of Clinical Molecular Biology, Christian-Albrechts-University, 24105 Kiel, Germany</aff><aff id="A22"><label>22</label>Centre for Biomedicine, EuropeanAcademy Bozen/Bolzano, Viale Druso 1, 39100 Bolzano, Italy</aff><aff id="A23"><label>23</label>Department of Biological Psychology, VU University Amsterdam, De Boelelaan 1105, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands</aff><aff id="A24"><label>24</label>MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Box 285, Cambridge CB2 0QQ, UK</aff><aff id="A25"><label>25</label>Interdisciplinary Centre for Clinical Research, University of Leipzig, Inselstr. 22, 04103 Leipzig, Germany</aff><aff id="A26"><label>26</label>Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK</aff><aff id="A27"><label>27</label>Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK</aff><aff id="A28"><label>28</label>Estonian Genome Center, University of Tartu, Tiigi 61b, 50410 Tartu, Estonia</aff><aff id="A29"><label>29</label>Estonian Biocenter, Riia 23b, 51010, Tartu, Estonia</aff><aff id="A30"><label>30</label>Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia</aff><aff id="A31"><label>31</label>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</aff><aff id="A32"><label>32</label>Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089-9075, USA</aff><aff id="A33"><label>33</label>Department of Nutrition-Dietetics, Harokopio University, Athens 17671, Greece</aff><aff id="A34"><label>34</label>Institute of Population Genetics, National Council of Research, 07100 Sassari, Italy</aff><aff id="A35"><label>35</label>University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, Maryland 21201-1559, USA</aff><aff id="A36"><label>36</label>Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands</aff><aff id="A37"><label>37</label>Department of Experimental Immunohaematology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands</aff><aff id="A38"><label>38</label>Inserm, CESP Centre for research in Epidemiology and Population Health, U1018Villejuif, 94807France</aff><aff id="A39"><label>39</label>University Paris Sud 11,UMRS 1018, Villejuif, 94807 France</aff><aff id="A40"><label>40</label>Service de Médecine Interne, CHUV, 1011 Lausanne, Switzerland</aff><aff id="A41"><label>41</label>Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, mmc 303, 420 Delaware St SE, Minneapolis, Minnesota 55455, USA</aff><aff id="A42"><label>42</label>Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</aff><aff id="A43"><label>43</label>Shardna Life Sciences, Loc. Piscinamanna 09010 Pula (CA), Italy</aff><aff id="A44"><label>44</label>Institute of Molecular Genetics-CNR Via Abbiategrasso 207, 27100 Pavia, Italy</aff><aff id="A45"><label>45</label>Istituto di Zootecnica, Universita’ Cattolica del Sacro Cuore sede Piacenza, via Emilia Parmense 84, 29122 Piacenza, Italy</aff><aff id="A46"><label>46</label>INSERM UMRS 937, Pierre and Marie Curie University (UPMC, Paris 6) and Medical School, 91 Bd de l’Hôpital, 75013 Paris, France.</aff><aff id="A47"><label>47</label>Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</aff><aff id="A48"><label>48</label>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</aff><aff id="A49"><label>49</label>MRC-HPA Centre for Environment and Health, Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK</aff><aff id="A50"><label>50</label>Universität zu Lübeck, Medizinische Klinik 2, Lübeck Germany</aff><aff id="A51"><label>51</label>MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK</aff><aff id="A52"><label>52</label>Department of Genomics of Common Disease, School of Public Health, Imperial College London, The Commonwealth Building, The Hammersmith Hospital, Du Care Road, London W12 ONN, UK</aff><aff id="A53"><label>53</label>The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia.</aff><aff id="A54"><label>54</label>Department of Medicine, Boston University, Boston, Massachusetts 02118, USA.</aff><aff id="A55"><label>55</label>Department of Clinical Sciences/Obstetrics and Gynecology, University of Oulu, Aapistie 7, Oulu, 90220 Finland</aff><aff id="A56"><label>56</label>Department of Epidemiology, University of Washington, Seattle, Washington 98195-7236, USA</aff><aff id="A57"><label>57</label>Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101-1448, USA</aff><aff id="A58"><label>58</label>Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany</aff><aff id="A59"><label>59</label>Department of Medical Genetics, University of Lausanne, and Swiss Institute of Bioinformatics, Lausanne, Switzerland</aff><aff id="A60"><label>60</label>Unit for Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr.1, 85764 Neuherberg, Germany</aff><aff id="A61"><label>61</label>Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK</aff><aff id="A62"><label>62</label>Clinical Gerontology Unit, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK</aff><aff id="A63"><label>63</label>First Department of Propedeutic Internal Medicine and Hematology Department, National and Kapodistrian University of Athens Medical School, Laikon General Hospital,Athens 11727, Greece</aff><aff id="A64"><label>64</label>Oxford Centre for Diabetes,Endocrinologyand Metabolism, University of Oxford, Oxford OX3 7LJ, UK</aff><aff id="A65"><label>65</label>Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA</aff><aff id="A66"><label>66</label>Genetic Epidemiology, Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston Road, Herston 4006, Queensland, Australia</aff><aff id="A67"><label>67</label>Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan</aff><aff id="A68"><label>68</label>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</aff><aff id="A69"><label>69</label>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</aff><aff id="A70"><label>70</label>Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University Kiel, 24105 Kiel, Germany</aff><aff id="A71"><label>71</label>Popgen Biobank, University Clinic Schleswig-Holstein, 24105 Kiel, Germany</aff><aff id="A72"><label>72</label>Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands</aff><aff id="A73"><label>73</label>Medical Genetics Section, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK</aff><aff id="A74"><label>74</label>National Institute for Health and Welfare, Aapistie 1, Oulu 90220, Finland</aff><aff id="A75"><label>75</label>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA</aff><aff id="A76"><label>76</label>Institute of Diagnostics, Clinical Chemistry, University of Oulu, Box 5000Y, University of Oulu, Oulu 90014, Finland</aff><aff id="A77"><label>77</label>NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK</aff><aff id="A78"><label>78</label>Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224-6825, USA</aff><aff id="A79"><label>79</label>Faculty of Medicine, National Heart and Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, London W12 0HS, UK</aff><aff id="A80"><label>80</label>Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, Washington 98108, USA</aff><aff id="A81"><label>81</label>Geriatric Medicine Unit, The University of Edinburgh, Royal Victoria, Craigleith Road, Edinburgh EH4 2DN, UK</aff><aff id="A82"><label>82</label>Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany</aff><aff id="A83"><label>83</label>Center for Cardiovascular Diagnostics and Prevention, Department of Cell Biology and Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA</aff><aff id="A84"><label>84</label>Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA</aff><aff id="A85"><label>85</label>Institute of Genetics and Molecular Medicine, MRC Human Genetics Unit, Edinburgh EH4 2XU, UK</aff><aff id="A86"><label>86</label>The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin Midlothian EH25 9RG, UK</aff><aff id="A87"><label>87</label>Department of Molecular Haematology, King’s College London, 125 Coldharbour Lane, London SE5 9NU, UK</aff><aff id="A88"><label>88</label>Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität and Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany</aff><aff id="A89"><label>89</label>Department of Physiatrics, Lapland Central Hospital, Rovaniemi, 96101, Finland</aff><aff id="A90"><label>90</label>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland 21208, USA.</aff><aff id="A91"><label>91</label>Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ, Groningen, The Netherlands</aff><aff id="A92"><label>92</label>Sanquin Research Leiden, Jon J. van Rood Center for Clinical Transfusion research, and the Department of Immuno-hematology and Blood Transfusion, Leiden University Medical Center, 2333 Leiden, The Netherlands</aff><aff id="A93"><label>93</label>Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA</aff><aff id="A94"><label>94</label>Institute of Health Sciences, University of Oulu, Aapistie 7, Oulu, 90220 Finland</aff><aff id="A95"><label>95</label>National Institute for Health and Welfare, Biocenter Oulu, University of Oulu, Aapistie 7, Oulu, 90220 Finland</aff><aff id="A96"><label>96</label>Department of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington 98101-1448, USA</aff><aff id="A97"><label>97</label>Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, 3584 CX Utrecht, Netherlands</aff><aff id="A98"><label>98</label>Institute for Immunology and Transfusion Medicine, Ernst-Moritz-Arndt-University Greifswald, 17475 Greifswald, Germany</aff><aff id="A99"><label>99</label>Proteomics Services, EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK</aff><aff id="A100"><label>100</label>MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 0SR, UK</aff><aff id="A101"><label>101</label>Nordic Center of Cardiovascular Research, Lubeck, Germany</aff><aff id="A102"><label>102</label>University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.</aff><author-notes><corresp id="CR1">Correspondence and requests for materials should be addressed to C.G. (<email>christian.gieger@helmholtz-muenchen.de</email>), W.H.O. (who1000@cam.ac.uk) or N.S. (<email>ns6@sanger.ac.uk</email>).</corresp><fn fn-type="equal" id="FN1"><label>*</label><p id="P1">These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>3</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>30</day><month>11</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>24</day><month>4</month><year>2012</year></pub-date><volume>480</volume><issue>7376</issue><fpage>201</fpage><lpage>208</lpage><permissions><copyright-statement>©2011 Macmillan Publishers Limited. All rights reserved</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P2">Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry, followed by extensive biological and functional assessment. We identified 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation. These genes show megakaryocyte-specific gene expression patterns and extensive network connectivity. Using gene silencing in <italic>Danio rerio</italic> and <italic>Drosophila melanogaster</italic>, we identified 11 of the genes as novel regulators of blood cell formation. Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function.</p></abstract><funding-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055021 || HC</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055020 || HC</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055015 || HC</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>UL1 RR025005-05 || RR</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>U54 RR020278-06 || RR</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>U01 HL084756-03 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>U01 HL072515-06 || HL</award-id></award-group><award-group><funding-source country="United States">National Institute of General Medical Sciences : NIGMS</funding-source><award-id>U01 GM074518-04 || GM</award-id></award-group><award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source><award-id>RL1 MH083268-05 || MH</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>R01 HL088119-04 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>R01 HL087679-03 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>R01 HL087641-03 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>R01 HL086694-05 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>R01 HL068986-06 || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>R01 HL059367-11 || HL</award-id></award-group><award-group><funding-source country="United States">National Institute of General Medical Sciences : NIGMS</funding-source><award-id>R01 GM053275-14 || GM</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG018728-05S1 || AG</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC085079 || HC</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055022 || HC</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055019 || HC</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055018 || HC</award-id></award-group><award-group><funding-source country="United States">Division of Epidemiology & Clinical Applications : NHLBI</funding-source><award-id>N01 HC055016 || HC</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>M01 RR016500-08 || RR</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>K12 RR023250-05 || RR</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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