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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A global benchmark study using affinity-based biosensors</title><author><name sortKey="Rich, Rebecca L" sort="Rich, Rebecca L" uniqKey="Rich R" first="Rebecca L." last="Rich">Rebecca L. Rich</name><affiliation><nlm:aff id="A1">Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author><author><name sortKey="Papalia, Giuseppe A" sort="Papalia, Giuseppe A" uniqKey="Papalia G" first="Giuseppe A." last="Papalia">Giuseppe A. Papalia</name><affiliation><nlm:aff id="A1">Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author><author><name sortKey="Flynn, Peter J" sort="Flynn, Peter J" uniqKey="Flynn P" first="Peter J." last="Flynn">Peter J. Flynn</name><affiliation><nlm:aff id="A2">KaloBios Pharmaceuticals, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Furneisen, Jamie" sort="Furneisen, Jamie" uniqKey="Furneisen J" first="Jamie" last="Furneisen">Jamie Furneisen</name><affiliation><nlm:aff id="A3">Schering–Plough Biopharma, Palo Alto, CA 94304, USA</nlm:aff></affiliation></author><author><name sortKey="Quinn, John" sort="Quinn, John" uniqKey="Quinn J" first="John" last="Quinn">John Quinn</name><affiliation><nlm:aff id="A4">Nomadics, Oklahoma City, OK 73104, USA</nlm:aff></affiliation></author><author><name sortKey="Klein, Joshua S" sort="Klein, Joshua S" uniqKey="Klein J" first="Joshua S." last="Klein">Joshua S. Klein</name><affiliation><nlm:aff id="A5">Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA 91125, USA</nlm:aff></affiliation></author><author><name sortKey="Katsamba, Phini S" sort="Katsamba, Phini S" uniqKey="Katsamba P" first="Phini S." last="Katsamba">Phini S. Katsamba</name><affiliation><nlm:aff id="A6">Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA</nlm:aff></affiliation></author><author><name sortKey="Waddell, M Brent" sort="Waddell, M Brent" uniqKey="Waddell M" first="M. Brent" last="Waddell">M. Brent Waddell</name><affiliation><nlm:aff id="A7">Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, Michael" sort="Scott, Michael" uniqKey="Scott M" first="Michael" last="Scott">Michael Scott</name><affiliation><nlm:aff id="A8">University of Zurich, CH-8057 Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Thompson, Joshua" sort="Thompson, Joshua" uniqKey="Thompson J" first="Joshua" last="Thompson">Joshua Thompson</name><affiliation><nlm:aff id="A9">Molecular Probes/Invitrogen, Eugene, OR 97402, USA</nlm:aff></affiliation></author><author><name sortKey="Berlier, Judie" sort="Berlier, Judie" uniqKey="Berlier J" first="Judie" last="Berlier">Judie Berlier</name><affiliation><nlm:aff id="A9">Molecular Probes/Invitrogen, Eugene, OR 97402, USA</nlm:aff></affiliation></author><author><name sortKey="Corry, Schuyler" sort="Corry, Schuyler" uniqKey="Corry S" first="Schuyler" last="Corry">Schuyler Corry</name><affiliation><nlm:aff id="A9">Molecular Probes/Invitrogen, Eugene, OR 97402, USA</nlm:aff></affiliation></author><author><name sortKey="Baltzinger, Mireille" sort="Baltzinger, Mireille" uniqKey="Baltzinger M" first="Mireille" last="Baltzinger">Mireille Baltzinger</name><affiliation><nlm:aff id="A10">University of Strasbourg, 67412 Illkirch, France</nlm:aff></affiliation></author><author><name sortKey="Zeder Lutz, Gabrielle" sort="Zeder Lutz, Gabrielle" uniqKey="Zeder Lutz G" first="Gabrielle" last="Zeder-Lutz">Gabrielle Zeder-Lutz</name><affiliation><nlm:aff id="A10">University of Strasbourg, 67412 Illkirch, France</nlm:aff></affiliation></author><author><name sortKey="Schoenemann, Andreas" sort="Schoenemann, Andreas" uniqKey="Schoenemann A" first="Andreas" last="Schoenemann">Andreas Schoenemann</name><affiliation><nlm:aff id="A11">Merck KGaA, D-64293 Darmstadt, Germany</nlm:aff></affiliation></author><author><name sortKey="Clabbers, Anca" sort="Clabbers, Anca" uniqKey="Clabbers A" first="Anca" last="Clabbers">Anca Clabbers</name><affiliation><nlm:aff id="A12">Abbott Bioresearch Center, Worcester, MA 01605, USA</nlm:aff></affiliation></author><author><name sortKey="Wieckowski, Sebastien" sort="Wieckowski, Sebastien" uniqKey="Wieckowski S" first="Sebastien" last="Wieckowski">Sebastien Wieckowski</name><affiliation><nlm:aff id="A13">Institute of Molecular and Cellular Biology, University of Strasbourg, 67084 Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Murphy, Mary M" sort="Murphy, Mary M" uniqKey="Murphy M" first="Mary M." last="Murphy">Mary M. Murphy</name><affiliation><nlm:aff id="A14">Reichert, Depew, NY 14043, USA</nlm:aff></affiliation></author><author><name sortKey="Page, Phillip" sort="Page, Phillip" uniqKey="Page P" first="Phillip" last="Page">Phillip Page</name><affiliation><nlm:aff id="A14">Reichert, Depew, NY 14043, USA</nlm:aff></affiliation></author><author><name sortKey="Ryan, Thomas E" sort="Ryan, Thomas E" uniqKey="Ryan T" first="Thomas E." last="Ryan">Thomas E. Ryan</name><affiliation><nlm:aff id="A14">Reichert, Depew, NY 14043, USA</nlm:aff></affiliation></author><author><name sortKey="Duffner, Jay" sort="Duffner, Jay" uniqKey="Duffner J" first="Jay" last="Duffner">Jay Duffner</name><affiliation><nlm:aff id="A15">Momenta Pharmaceuticals, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Ganguly, Tanmoy" sort="Ganguly, Tanmoy" uniqKey="Ganguly T" first="Tanmoy" last="Ganguly">Tanmoy Ganguly</name><affiliation><nlm:aff id="A15">Momenta Pharmaceuticals, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Corbin, John" sort="Corbin, John" uniqKey="Corbin J" first="John" last="Corbin">John Corbin</name><affiliation><nlm:aff id="A16">XOMA (U.S.), Emeryville, CA 94608, USA</nlm:aff></affiliation></author><author><name sortKey="Gautam, Satyen" sort="Gautam, Satyen" uniqKey="Gautam S" first="Satyen" last="Gautam">Satyen Gautam</name><affiliation><nlm:aff id="A17">Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 119260, Singapore</nlm:aff></affiliation></author><author><name sortKey="Anderluh, Gregor" sort="Anderluh, Gregor" uniqKey="Anderluh G" first="Gregor" last="Anderluh">Gregor Anderluh</name><affiliation><nlm:aff id="A18">Department of Biology, University of Ljubljiana, 1000 Ljubljiana, Slovenia</nlm:aff></affiliation></author><author><name sortKey="Bavdek, Andrej" sort="Bavdek, Andrej" uniqKey="Bavdek A" first="Andrej" last="Bavdek">Andrej Bavdek</name><affiliation><nlm:aff id="A18">Department of Biology, University of Ljubljiana, 1000 Ljubljiana, Slovenia</nlm:aff></affiliation></author><author><name sortKey="Reichmann, Dana" sort="Reichmann, Dana" uniqKey="Reichmann D" first="Dana" last="Reichmann">Dana Reichmann</name><affiliation><nlm:aff id="A19">Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel</nlm:aff></affiliation></author><author><name sortKey="Yadav, Satya P" sort="Yadav, Satya P" uniqKey="Yadav S" first="Satya P." last="Yadav">Satya P. Yadav</name><affiliation><nlm:aff id="A20">Molecular Biotechnology Core Laboratory, Cleveland Clinic Foundation, Cleveland, OH 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Hommema, Eric" sort="Hommema, Eric" uniqKey="Hommema E" first="Eric" last="Hommema">Eric Hommema</name><affiliation><nlm:aff id="A21">ThermoFisher Scientific, Rockford, IL 61101, USA</nlm:aff></affiliation></author><author><name sortKey="Pol, Ewa" sort="Pol, Ewa" uniqKey="Pol E" first="Ewa" last="Pol">Ewa Pol</name><affiliation><nlm:aff id="A22">Biacore/GE Healthcare, SE-754 50 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Drake, Andrew" sort="Drake, Andrew" uniqKey="Drake A" first="Andrew" last="Drake">Andrew Drake</name><affiliation><nlm:aff id="A23">AstraZeneca, Hayward, CA 94545, USA</nlm:aff></affiliation></author><author><name sortKey="Klakamp, Scott" sort="Klakamp, Scott" uniqKey="Klakamp S" first="Scott" last="Klakamp">Scott Klakamp</name><affiliation><nlm:aff id="A23">AstraZeneca, Hayward, CA 94545, USA</nlm:aff></affiliation></author><author><name sortKey="Chapman, Trevor" sort="Chapman, Trevor" uniqKey="Chapman T" first="Trevor" last="Chapman">Trevor Chapman</name><affiliation><nlm:aff id="A24">Neurodegeneration Research Department, GlaxoSmithKline, Harlow CM19 5AW, UK</nlm:aff></affiliation></author><author><name sortKey="Kernaghan, Dawn" sort="Kernaghan, Dawn" uniqKey="Kernaghan D" first="Dawn" last="Kernaghan">Dawn Kernaghan</name><affiliation><nlm:aff id="A25">MedImmune, Gaithersburg, MD 20878, USA</nlm:aff></affiliation></author><author><name sortKey="Miller, Ken" sort="Miller, Ken" uniqKey="Miller K" first="Ken" last="Miller">Ken Miller</name><affiliation><nlm:aff id="A25">MedImmune, Gaithersburg, MD 20878, USA</nlm:aff></affiliation></author><author><name sortKey="Schuman, Jason" sort="Schuman, Jason" uniqKey="Schuman J" first="Jason" last="Schuman">Jason Schuman</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Lindquist, Kevin" sort="Lindquist, Kevin" uniqKey="Lindquist K" first="Kevin" last="Lindquist">Kevin Lindquist</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Herlihy, Kara" sort="Herlihy, Kara" uniqKey="Herlihy K" first="Kara" last="Herlihy">Kara Herlihy</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Murphy, Michael B" sort="Murphy, Michael B" uniqKey="Murphy M" first="Michael B." last="Murphy">Michael B. Murphy</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Bohnsack, Richard" sort="Bohnsack, Richard" uniqKey="Bohnsack R" first="Richard" last="Bohnsack">Richard Bohnsack</name><affiliation><nlm:aff id="A27">Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA</nlm:aff></affiliation></author><author><name sortKey="Andrien, Bruce" sort="Andrien, Bruce" uniqKey="Andrien B" first="Bruce" last="Andrien">Bruce Andrien</name><affiliation><nlm:aff id="A28">Alexion Pharmaceuticals, Cheshire, CT 06410, USA</nlm:aff></affiliation></author><author><name sortKey="Brandani, Pietro" sort="Brandani, Pietro" uniqKey="Brandani P" first="Pietro" last="Brandani">Pietro Brandani</name><affiliation><nlm:aff id="A29">Applied Biosystems, Foster City, CA 94404, USA</nlm:aff></affiliation></author><author><name sortKey="Terwey, Danny" sort="Terwey, Danny" uniqKey="Terwey D" first="Danny" last="Terwey">Danny Terwey</name><affiliation><nlm:aff id="A30">diaDexus, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Millican, Rohn" sort="Millican, Rohn" uniqKey="Millican R" first="Rohn" last="Millican">Rohn Millican</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Darling, Ryan J" sort="Darling, Ryan J" uniqKey="Darling R" first="Ryan J." last="Darling">Ryan J. Darling</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Liann" sort="Wang, Liann" uniqKey="Wang L" first="Liann" last="Wang">Liann Wang</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Carter, Quincy" sort="Carter, Quincy" uniqKey="Carter Q" first="Quincy" last="Carter">Quincy Carter</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Dotzlaf, Joe" sort="Dotzlaf, Joe" uniqKey="Dotzlaf J" first="Joe" last="Dotzlaf">Joe Dotzlaf</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Lopez Sagaseta, Jacinto" sort="Lopez Sagaseta, Jacinto" uniqKey="Lopez Sagaseta J" first="Jacinto" last="Lopez-Sagaseta">Jacinto Lopez-Sagaseta</name><affiliation><nlm:aff id="A32">Laboratory of Thrombosis and Haemostasis, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Campbell, Islay" sort="Campbell, Islay" uniqKey="Campbell I" first="Islay" last="Campbell">Islay Campbell</name><affiliation><nlm:aff id="A33">EMD Lexigen Research Center, Billerica, MA 01821, USA</nlm:aff></affiliation></author><author><name sortKey="Torreri, Paola" sort="Torreri, Paola" uniqKey="Torreri P" first="Paola" last="Torreri">Paola Torreri</name><affiliation><nlm:aff id="A34">Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Hoos, Sylviane" sort="Hoos, Sylviane" uniqKey="Hoos S" first="Sylviane" last="Hoos">Sylviane Hoos</name><affiliation><nlm:aff id="A35">Department of Structural Biology and Chemistry, Pasteur Institute, 75724 Paris, France</nlm:aff></affiliation></author><author><name sortKey="England, Patrick" sort="England, Patrick" uniqKey="England P" first="Patrick" last="England">Patrick England</name><affiliation><nlm:aff id="A35">Department of Structural Biology and Chemistry, Pasteur Institute, 75724 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation><nlm:aff id="A36">Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA</nlm:aff></affiliation></author><author><name sortKey="Abdiche, Yasmina" sort="Abdiche, Yasmina" uniqKey="Abdiche Y" first="Yasmina" last="Abdiche">Yasmina Abdiche</name><affiliation><nlm:aff id="A37">Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Malashock, Daniel" sort="Malashock, Daniel" uniqKey="Malashock D" first="Daniel" last="Malashock">Daniel Malashock</name><affiliation><nlm:aff id="A37">Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Pinkerton, Alanna" sort="Pinkerton, Alanna" uniqKey="Pinkerton A" first="Alanna" last="Pinkerton">Alanna Pinkerton</name><affiliation><nlm:aff id="A37">Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><nlm:aff id="A38">PDL BioPharma, Fremont, CA 94555, USA</nlm:aff></affiliation></author><author><name sortKey="Lafer, Eileen" sort="Lafer, Eileen" uniqKey="Lafer E" first="Eileen" last="Lafer">Eileen Lafer</name><affiliation><nlm:aff id="A39">Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA</nlm:aff></affiliation></author><author><name sortKey="Hinck, Cynthia" sort="Hinck, Cynthia" uniqKey="Hinck C" first="Cynthia" last="Hinck">Cynthia Hinck</name><affiliation><nlm:aff id="A39">Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA</nlm:aff></affiliation></author><author><name sortKey="Thompson, Kevin" sort="Thompson, Kevin" uniqKey="Thompson K" first="Kevin" last="Thompson">Kevin Thompson</name><affiliation><nlm:aff id="A40">Akubio, Cambridge CB4 0GJ, UK</nlm:aff></affiliation></author><author><name sortKey="Primo, Carmelo Di" sort="Primo, Carmelo Di" uniqKey="Primo C" first="Carmelo Di" last="Primo">Carmelo Di Primo</name><affiliation><nlm:aff id="A41">INSERM U869, Institut Europeen de Chimie et Biologie, University of Bordeaux, 33607 Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Joyce, Alison" sort="Joyce, Alison" uniqKey="Joyce A" first="Alison" last="Joyce">Alison Joyce</name><affiliation><nlm:aff id="A42">Wyeth Research, Cambridge, MA 02140, USA</nlm:aff></affiliation></author><author><name sortKey="Brooks, Jonathan" sort="Brooks, Jonathan" uniqKey="Brooks J" first="Jonathan" last="Brooks">Jonathan Brooks</name><affiliation><nlm:aff id="A42">Wyeth Research, Cambridge, MA 02140, USA</nlm:aff></affiliation></author><author><name sortKey="Torta, Federico" sort="Torta, Federico" uniqKey="Torta F" first="Federico" last="Torta">Federico Torta</name><affiliation><nlm:aff id="A43">Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bagge Hagel, Anne Birgitte" sort="Bagge Hagel, Anne Birgitte" uniqKey="Bagge Hagel A" first="Anne Birgitte" last="Bagge Hagel">Anne Birgitte Bagge Hagel</name><affiliation><nlm:aff id="A44">NovoNordisk, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Krarup, Janus" sort="Krarup, Janus" uniqKey="Krarup J" first="Janus" last="Krarup">Janus Krarup</name><affiliation><nlm:aff id="A44">NovoNordisk, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pass, Jesper" sort="Pass, Jesper" uniqKey="Pass J" first="Jesper" last="Pass">Jesper Pass</name><affiliation><nlm:aff id="A44">NovoNordisk, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Monica" sort="Ferreira, Monica" uniqKey="Ferreira M" first="Monica" last="Ferreira">Monica Ferreira</name><affiliation><nlm:aff id="A45">Södertörns University College, 14152 Huddinge, Sweden</nlm:aff></affiliation></author><author><name sortKey="Shikov, Sergei" sort="Shikov, Sergei" uniqKey="Shikov S" first="Sergei" last="Shikov">Sergei Shikov</name><affiliation><nlm:aff id="A46">Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA</nlm:aff></affiliation></author><author><name sortKey="Mikolajczyk, Malgorzata" sort="Mikolajczyk, Malgorzata" uniqKey="Mikolajczyk M" first="Malgorzata" last="Mikolajczyk">Malgorzata Mikolajczyk</name><affiliation><nlm:aff id="A47">U.S. Food and Drug Administration, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Abe, Yuki" sort="Abe, Yuki" uniqKey="Abe Y" first="Yuki" last="Abe">Yuki Abe</name><affiliation><nlm:aff id="A48">Department of Biochemical Engineering, University College London, London WC1E 7JE, UK</nlm:aff></affiliation></author><author><name sortKey="Barbato, Gaetano" sort="Barbato, Gaetano" uniqKey="Barbato G" first="Gaetano" last="Barbato">Gaetano Barbato</name><affiliation><nlm:aff id="A49">Merck, 00040 Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Giannetti, Anthony M" sort="Giannetti, Anthony M" uniqKey="Giannetti A" first="Anthony M." last="Giannetti">Anthony M. Giannetti</name><affiliation><nlm:aff id="A50">Roche, Palo Alto, CA 94304, USA</nlm:aff></affiliation></author><author><name sortKey="Krishnamoorthy, Ganeshram" sort="Krishnamoorthy, Ganeshram" uniqKey="Krishnamoorthy G" first="Ganeshram" last="Krishnamoorthy">Ganeshram Krishnamoorthy</name><affiliation><nlm:aff id="A51">University of Twente, 7500AE Enschede, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beusink, Bianca" sort="Beusink, Bianca" uniqKey="Beusink B" first="Bianca" last="Beusink">Bianca Beusink</name><affiliation><nlm:aff id="A51">University of Twente, 7500AE Enschede, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Satpaev, Daulet" sort="Satpaev, Daulet" uniqKey="Satpaev D" first="Daulet" last="Satpaev">Daulet Satpaev</name><affiliation><nlm:aff id="A52">Agensys, Santa Monica, CA 90404, USA</nlm:aff></affiliation></author><author><name sortKey="Tsang, Tiffany" sort="Tsang, Tiffany" uniqKey="Tsang T" first="Tiffany" last="Tsang">Tiffany Tsang</name><affiliation><nlm:aff id="A53">Novartis, Emeryville, CA 94608, USA</nlm:aff></affiliation></author><author><name sortKey="Fang, Eric" sort="Fang, Eric" uniqKey="Fang E" first="Eric" last="Fang">Eric Fang</name><affiliation><nlm:aff id="A53">Novartis, Emeryville, CA 94608, USA</nlm:aff></affiliation></author><author><name sortKey="Partridge, James" sort="Partridge, James" uniqKey="Partridge J" first="James" last="Partridge">James Partridge</name><affiliation><nlm:aff id="A54">Massachusetts Institute of Technology, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Brohawn, Stephen" sort="Brohawn, Stephen" uniqKey="Brohawn S" first="Stephen" last="Brohawn">Stephen Brohawn</name><affiliation><nlm:aff id="A54">Massachusetts Institute of Technology, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Horn, James" sort="Horn, James" uniqKey="Horn J" first="James" last="Horn">James Horn</name><affiliation><nlm:aff id="A55">Northern Illinois University, DeKalb, IL 60115, USA</nlm:aff></affiliation></author><author><name sortKey="Pritsch, Otto" sort="Pritsch, Otto" uniqKey="Pritsch O" first="Otto" last="Pritsch">Otto Pritsch</name><affiliation><nlm:aff id="A56">Pasteur Institute of Montevideo, CP 11400 Montevideo, Uruguay</nlm:aff></affiliation></author><author><name sortKey="Obal, Gonzalo" sort="Obal, Gonzalo" uniqKey="Obal G" first="Gonzalo" last="Obal">Gonzalo Obal</name><affiliation><nlm:aff id="A56">Pasteur Institute of Montevideo, CP 11400 Montevideo, Uruguay</nlm:aff></affiliation></author><author><name sortKey="Nilapwar, Sanjay" sort="Nilapwar, Sanjay" uniqKey="Nilapwar S" first="Sanjay" last="Nilapwar">Sanjay Nilapwar</name><affiliation><nlm:aff id="A57">University of Manchester, Manchester M1 7ND, UK</nlm:aff></affiliation></author><author><name sortKey="Busby, Ben" sort="Busby, Ben" uniqKey="Busby B" first="Ben" last="Busby">Ben Busby</name><affiliation><nlm:aff id="A58">Department of Physiology, University of Maryland, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Gutierrez Sanchez, Gerardo" sort="Gutierrez Sanchez, Gerardo" uniqKey="Gutierrez Sanchez G" first="Gerardo" last="Gutierrez-Sanchez">Gerardo Gutierrez-Sanchez</name><affiliation><nlm:aff id="A59">Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA</nlm:aff></affiliation></author><author><name sortKey="Gupta, Ruchira Das" sort="Gupta, Ruchira Das" uniqKey="Gupta R" first="Ruchira Das" last="Gupta">Ruchira Das Gupta</name><affiliation><nlm:aff id="A60">Adnexus Therapeutics, Waltham, MA 02453, USA</nlm:aff></affiliation></author><author><name sortKey="Canepa, Sylvie" sort="Canepa, Sylvie" uniqKey="Canepa S" first="Sylvie" last="Canepa">Sylvie Canepa</name><affiliation><nlm:aff id="A61">University of Tours, 37380 Nouzilly, France</nlm:aff></affiliation></author><author><name sortKey="Witte, Krista" sort="Witte, Krista" uniqKey="Witte K" first="Krista" last="Witte">Krista Witte</name><affiliation><nlm:aff id="A62">ForteBio, Menlo Park, CA 94025, USA</nlm:aff></affiliation></author><author><name sortKey="Nikolovska Coleska, Zaneta" sort="Nikolovska Coleska, Zaneta" uniqKey="Nikolovska Coleska Z" first="Zaneta" last="Nikolovska-Coleska">Zaneta Nikolovska-Coleska</name><affiliation><nlm:aff id="A63">University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Cho, Yun Hee" sort="Cho, Yun Hee" uniqKey="Cho Y" first="Yun Hee" last="Cho">Yun Hee Cho</name><affiliation><nlm:aff id="A64">Human Genome Sciences, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="D Gata, Roberta" sort="D Gata, Roberta" uniqKey="D Gata R" first="Roberta" last="D Gata">Roberta D Gata</name><affiliation><nlm:aff id="A65">Department of Chemical Sciences, University of Catania, 95125 Catania, Italy</nlm:aff></affiliation></author><author><name sortKey="Schlick, Kristian" sort="Schlick, Kristian" uniqKey="Schlick K" first="Kristian" last="Schlick">Kristian Schlick</name><affiliation><nlm:aff id="A66">Montana State University, Bozeman, MT 59717, USA</nlm:aff></affiliation></author><author><name sortKey="Calvert, Rosy" sort="Calvert, Rosy" uniqKey="Calvert R" first="Rosy" last="Calvert">Rosy Calvert</name><affiliation><nlm:aff id="A67">GKT School of Biomedical Sciences, London SE1 1UL, UK</nlm:aff></affiliation></author><author><name sortKey="Munoz, Eva M" sort="Munoz, Eva M" uniqKey="Munoz E" first="Eva M." last="Munoz">Eva M. Munoz</name><affiliation><nlm:aff id="A68">Organic and Pharmaceutical Chemistry Department, Complutense University, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Hernaiz, Maria Jose" sort="Hernaiz, Maria Jose" uniqKey="Hernaiz M" first="Maria Jose" last="Hernaiz">Maria Jose Hernaiz</name><affiliation><nlm:aff id="A68">Organic and Pharmaceutical Chemistry Department, Complutense University, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Bravman, Tsafir" sort="Bravman, Tsafir" uniqKey="Bravman T" first="Tsafir" last="Bravman">Tsafir Bravman</name><affiliation><nlm:aff id="A69">Bio-Rad Haifa, 32000 Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Dines, Monica" sort="Dines, Monica" uniqKey="Dines M" first="Monica" last="Dines">Monica Dines</name><affiliation><nlm:aff id="A69">Bio-Rad Haifa, 32000 Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Yang, Min Hsiang" sort="Yang, Min Hsiang" uniqKey="Yang M" first="Min-Hsiang" last="Yang">Min-Hsiang Yang</name><affiliation><nlm:aff id="A70">Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Puskas, Agnes" sort="Puskas, Agnes" uniqKey="Puskas A" first="Agnes" last="Puskas">Agnes Puskas</name><affiliation><nlm:aff id="A71">University of Texas Medical School at Houston, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Boni, Erica" sort="Boni, Erica" uniqKey="Boni E" first="Erica" last="Boni">Erica Boni</name><affiliation><nlm:aff id="A72">Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jiejin" sort="Li, Jiejin" uniqKey="Li J" first="Jiejin" last="Li">Jiejin Li</name><affiliation><nlm:aff id="A73">Division of Molecular Structure, National Institute of Medical Research (UK), London NW7 1AA, UK</nlm:aff></affiliation></author><author><name sortKey="Wear, Martin" sort="Wear, Martin" uniqKey="Wear M" first="Martin" last="Wear">Martin Wear</name><affiliation><nlm:aff id="A74">Centre for Translational and Chemical Biology, Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK</nlm:aff></affiliation></author><author><name sortKey="Grinberg, Asya" sort="Grinberg, Asya" uniqKey="Grinberg A" first="Asya" last="Grinberg">Asya Grinberg</name><affiliation><nlm:aff id="A75">Acceleron Pharma, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Baardsnes, Jason" sort="Baardsnes, Jason" uniqKey="Baardsnes J" first="Jason" last="Baardsnes">Jason Baardsnes</name><affiliation><nlm:aff id="A76">National Research Council (Canada), Biotechnology Research Institute, Montreal, Que., Canada H4P 2R2</nlm:aff></affiliation></author><author><name sortKey="Dolezal, Olan" sort="Dolezal, Olan" uniqKey="Dolezal O" first="Olan" last="Dolezal">Olan Dolezal</name><affiliation><nlm:aff id="A77">CSIRO Health Sciences and Nutrition, Parkville, VIC 3052, Australia</nlm:aff></affiliation></author><author><name sortKey="Gainey, Melicia" sort="Gainey, Melicia" uniqKey="Gainey M" first="Melicia" last="Gainey">Melicia Gainey</name><affiliation><nlm:aff id="A78">Battelle Biomedical Research Center, Columbus, OH 43201, USA</nlm:aff></affiliation></author><author><name sortKey="Anderson, Henrik" sort="Anderson, Henrik" uniqKey="Anderson H" first="Henrik" last="Anderson">Henrik Anderson</name><affiliation><nlm:aff id="A79">Attana AB, SE-113 47 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Peng, Jinlin" sort="Peng, Jinlin" uniqKey="Peng J" first="Jinlin" last="Peng">Jinlin Peng</name><affiliation><nlm:aff id="A80">Corning, Corning, NY 14831, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Mark" sort="Lewis, Mark" uniqKey="Lewis M" first="Mark" last="Lewis">Mark Lewis</name><affiliation><nlm:aff id="A80">Corning, Corning, NY 14831, USA</nlm:aff></affiliation></author><author><name sortKey="Spies, Peter" sort="Spies, Peter" uniqKey="Spies P" first="Peter" last="Spies">Peter Spies</name><affiliation><nlm:aff id="A81">School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland, CH-4132 Muttenz, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Trinh, Quyhn" sort="Trinh, Quyhn" uniqKey="Trinh Q" first="Quyhn" last="Trinh">Quyhn Trinh</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Bibikov, Sergei" sort="Bibikov, Sergei" uniqKey="Bibikov S" first="Sergei" last="Bibikov">Sergei Bibikov</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Raymond, Jill" sort="Raymond, Jill" uniqKey="Raymond J" first="Jill" last="Raymond">Jill Raymond</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Yousef, Mohammed" sort="Yousef, Mohammed" uniqKey="Yousef M" first="Mohammed" last="Yousef">Mohammed Yousef</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Chandrasekaran, Vidya" sort="Chandrasekaran, Vidya" uniqKey="Chandrasekaran V" first="Vidya" last="Chandrasekaran">Vidya Chandrasekaran</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Feng, Yuguo" sort="Feng, Yuguo" uniqKey="Feng Y" first="Yuguo" last="Feng">Yuguo Feng</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Emerick, Anne" sort="Emerick, Anne" uniqKey="Emerick A" first="Anne" last="Emerick">Anne Emerick</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Mundodo, Suparna" sort="Mundodo, Suparna" uniqKey="Mundodo S" first="Suparna" last="Mundodo">Suparna Mundodo</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Guimaraes, Rejane" sort="Guimaraes, Rejane" uniqKey="Guimaraes R" first="Rejane" last="Guimaraes">Rejane Guimaraes</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Mcgirr, Katy" sort="Mcgirr, Katy" uniqKey="Mcgirr K" first="Katy" last="Mcgirr">Katy Mcgirr</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Yue Ji" sort="Li, Yue Ji" uniqKey="Li Y" first="Yue-Ji" last="Li">Yue-Ji Li</name><affiliation><nlm:aff id="A83">Monsanto, Chesterfield, MO 63198, USA</nlm:aff></affiliation></author><author><name sortKey="Hughes, Heather" sort="Hughes, Heather" uniqKey="Hughes H" first="Heather" last="Hughes">Heather Hughes</name><affiliation><nlm:aff id="A84">Genzyme, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Mantz, Hubert" sort="Mantz, Hubert" uniqKey="Mantz H" first="Hubert" last="Mantz">Hubert Mantz</name><affiliation><nlm:aff id="A85">Saarland University, D-66041 Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Skrabana, Rostislav" sort="Skrabana, Rostislav" uniqKey="Skrabana R" first="Rostislav" last="Skrabana">Rostislav Skrabana</name><affiliation><nlm:aff id="A86">Institute of Neuroimmunology of SAS, 84510 Bratislava, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Witmer, Mark" sort="Witmer, Mark" uniqKey="Witmer M" first="Mark" last="Witmer">Mark Witmer</name><affiliation><nlm:aff id="A87">Bristol–Myers Squibb, Princeton, NJ 08543, USA</nlm:aff></affiliation></author><author><name sortKey="Ballard, Joshua" sort="Ballard, Joshua" uniqKey="Ballard J" first="Joshua" last="Ballard">Joshua Ballard</name><affiliation><nlm:aff id="A88">Array Biopharma, Boulder, CO 80301, USA</nlm:aff></affiliation></author><author><name sortKey="Martin, Loic" sort="Martin, Loic" uniqKey="Martin L" first="Loic" last="Martin">Loic Martin</name><affiliation><nlm:aff id="A89">CEA, iBiTecs, Service d’Ingénierie Moléculaire des Protéines, 91191 Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Skladal, Petr" sort="Skladal, Petr" uniqKey="Skladal P" first="Petr" last="Skladal">Petr Skladal</name><affiliation><nlm:aff id="A90">Department of Biochemistry, Masaryk University, 61137 Brno, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Korza, George" sort="Korza, George" uniqKey="Korza G" first="George" last="Korza">George Korza</name><affiliation><nlm:aff id="A91">University of Connecticut Health Center, Farmington, CT 06030, USA</nlm:aff></affiliation></author><author><name sortKey="Laird Offringa, Ite" sort="Laird Offringa, Ite" uniqKey="Laird Offringa I" first="Ite" last="Laird-Offringa">Ite Laird-Offringa</name><affiliation><nlm:aff id="A92">University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Charlene S" sort="Lee, Charlene S" uniqKey="Lee C" first="Charlene S." last="Lee">Charlene S. Lee</name><affiliation><nlm:aff id="A92">University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Khadir, Abdelkrim" sort="Khadir, Abdelkrim" uniqKey="Khadir A" first="Abdelkrim" last="Khadir">Abdelkrim Khadir</name><affiliation><nlm:aff id="A93">GeminX Biotechnologies, Montreal, Que., Canada H2X 2H7</nlm:aff></affiliation></author><author><name sortKey="Podlaski, Frank" sort="Podlaski, Frank" uniqKey="Podlaski F" first="Frank" last="Podlaski">Frank Podlaski</name><affiliation><nlm:aff id="A94">Hoffman–La Roche, Nutley, NJ 07110, USA</nlm:aff></affiliation></author><author><name sortKey="Neuner, Phillippe" sort="Neuner, Phillippe" uniqKey="Neuner P" first="Phillippe" last="Neuner">Phillippe Neuner</name><affiliation><nlm:aff id="A95">IRBM, Pomezia, 00040 Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Rothacker, Julie" sort="Rothacker, Julie" uniqKey="Rothacker J" first="Julie" last="Rothacker">Julie Rothacker</name><affiliation><nlm:aff id="A96">Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia</nlm:aff></affiliation></author><author><name sortKey="Rafique, Ashique" sort="Rafique, Ashique" uniqKey="Rafique A" first="Ashique" last="Rafique">Ashique Rafique</name><affiliation><nlm:aff id="A97">Regeneron, Tarrytown, NY 10591, USA</nlm:aff></affiliation></author><author><name sortKey="Dankbar, Nico" sort="Dankbar, Nico" uniqKey="Dankbar N" first="Nico" last="Dankbar">Nico Dankbar</name><affiliation><nlm:aff id="A98">University of Muenster, D-48149 Muenster, Germany</nlm:aff></affiliation></author><author><name sortKey="Kainz, Peter" sort="Kainz, Peter" uniqKey="Kainz P" first="Peter" last="Kainz">Peter Kainz</name><affiliation><nlm:aff id="A99">Department of Molecular Biology, University of Salzburg, A-5020 Salzburg, Austria</nlm:aff></affiliation></author><author><name sortKey="Gedig, Erk" sort="Gedig, Erk" uniqKey="Gedig E" first="Erk" last="Gedig">Erk Gedig</name><affiliation><nlm:aff id="A100">XanTec Bioanalytics, D-48149 Muenster, Germany</nlm:aff></affiliation></author><author><name sortKey="Vuyisich, Momchilo" sort="Vuyisich, Momchilo" uniqKey="Vuyisich M" first="Momchilo" last="Vuyisich">Momchilo Vuyisich</name><affiliation><nlm:aff id="A101">Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA</nlm:aff></affiliation></author><author><name sortKey="Boozer, Christina" sort="Boozer, Christina" uniqKey="Boozer C" first="Christina" last="Boozer">Christina Boozer</name><affiliation><nlm:aff id="A102">Lumera, Bothell, WA 98011, USA</nlm:aff></affiliation></author><author><name sortKey="Ly, Nguyen" sort="Ly, Nguyen" uniqKey="Ly N" first="Nguyen" last="Ly">Nguyen Ly</name><affiliation><nlm:aff id="A103">Arizona State University, Tempe, AZ 85287, USA</nlm:aff></affiliation></author><author><name sortKey="Toews, Mark" sort="Toews, Mark" uniqKey="Toews M" first="Mark" last="Toews">Mark Toews</name><affiliation><nlm:aff id="A104">Dyax, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Uren, Aykut" sort="Uren, Aykut" uniqKey="Uren A" first="Aykut" last="Uren">Aykut Uren</name><affiliation><nlm:aff id="A105">Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA</nlm:aff></affiliation></author><author><name sortKey="Kalyuzhniy, Oleksandr" sort="Kalyuzhniy, Oleksandr" uniqKey="Kalyuzhniy O" first="Oleksandr" last="Kalyuzhniy">Oleksandr Kalyuzhniy</name><affiliation><nlm:aff id="A106">Department of Biochemistry, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Kenneth" sort="Lewis, Kenneth" uniqKey="Lewis K" first="Kenneth" last="Lewis">Kenneth Lewis</name><affiliation><nlm:aff id="A107">Zymogenetics, Seattle, WA 98102, USA</nlm:aff></affiliation></author><author><name sortKey="Chomey, Eugene" sort="Chomey, Eugene" uniqKey="Chomey E" first="Eugene" last="Chomey">Eugene Chomey</name><affiliation><nlm:aff id="A108">Bio-Rad Canada, Edmonton, Alta., Canada T6R 2W6</nlm:aff></affiliation></author><author><name sortKey="Pak, Brian J" sort="Pak, Brian J" uniqKey="Pak B" first="Brian J." last="Pak">Brian J. Pak</name><affiliation><nlm:aff id="A109">Bio-Rad Canada, Toronto, Ont., Canada</nlm:aff></affiliation></author><author><name sortKey="Myszka, David G" sort="Myszka, David G" uniqKey="Myszka D" first="David G." last="Myszka">David G. Myszka</name><affiliation><nlm:aff id="A1">Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19133223</idno><idno type="pmc">3793259</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793259</idno><idno type="RBID">PMC:3793259</idno><idno type="doi">10.1016/j.ab.2008.11.021</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001C91</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C91</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A global benchmark study using affinity-based biosensors</title><author><name sortKey="Rich, Rebecca L" sort="Rich, Rebecca L" uniqKey="Rich R" first="Rebecca L." last="Rich">Rebecca L. Rich</name><affiliation><nlm:aff id="A1">Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author><author><name sortKey="Papalia, Giuseppe A" sort="Papalia, Giuseppe A" uniqKey="Papalia G" first="Giuseppe A." last="Papalia">Giuseppe A. Papalia</name><affiliation><nlm:aff id="A1">Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author><author><name sortKey="Flynn, Peter J" sort="Flynn, Peter J" uniqKey="Flynn P" first="Peter J." last="Flynn">Peter J. Flynn</name><affiliation><nlm:aff id="A2">KaloBios Pharmaceuticals, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Furneisen, Jamie" sort="Furneisen, Jamie" uniqKey="Furneisen J" first="Jamie" last="Furneisen">Jamie Furneisen</name><affiliation><nlm:aff id="A3">Schering–Plough Biopharma, Palo Alto, CA 94304, USA</nlm:aff></affiliation></author><author><name sortKey="Quinn, John" sort="Quinn, John" uniqKey="Quinn J" first="John" last="Quinn">John Quinn</name><affiliation><nlm:aff id="A4">Nomadics, Oklahoma City, OK 73104, USA</nlm:aff></affiliation></author><author><name sortKey="Klein, Joshua S" sort="Klein, Joshua S" uniqKey="Klein J" first="Joshua S." last="Klein">Joshua S. Klein</name><affiliation><nlm:aff id="A5">Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA 91125, USA</nlm:aff></affiliation></author><author><name sortKey="Katsamba, Phini S" sort="Katsamba, Phini S" uniqKey="Katsamba P" first="Phini S." last="Katsamba">Phini S. Katsamba</name><affiliation><nlm:aff id="A6">Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA</nlm:aff></affiliation></author><author><name sortKey="Waddell, M Brent" sort="Waddell, M Brent" uniqKey="Waddell M" first="M. Brent" last="Waddell">M. Brent Waddell</name><affiliation><nlm:aff id="A7">Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</nlm:aff></affiliation></author><author><name sortKey="Scott, Michael" sort="Scott, Michael" uniqKey="Scott M" first="Michael" last="Scott">Michael Scott</name><affiliation><nlm:aff id="A8">University of Zurich, CH-8057 Zurich, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Thompson, Joshua" sort="Thompson, Joshua" uniqKey="Thompson J" first="Joshua" last="Thompson">Joshua Thompson</name><affiliation><nlm:aff id="A9">Molecular Probes/Invitrogen, Eugene, OR 97402, USA</nlm:aff></affiliation></author><author><name sortKey="Berlier, Judie" sort="Berlier, Judie" uniqKey="Berlier J" first="Judie" last="Berlier">Judie Berlier</name><affiliation><nlm:aff id="A9">Molecular Probes/Invitrogen, Eugene, OR 97402, USA</nlm:aff></affiliation></author><author><name sortKey="Corry, Schuyler" sort="Corry, Schuyler" uniqKey="Corry S" first="Schuyler" last="Corry">Schuyler Corry</name><affiliation><nlm:aff id="A9">Molecular Probes/Invitrogen, Eugene, OR 97402, USA</nlm:aff></affiliation></author><author><name sortKey="Baltzinger, Mireille" sort="Baltzinger, Mireille" uniqKey="Baltzinger M" first="Mireille" last="Baltzinger">Mireille Baltzinger</name><affiliation><nlm:aff id="A10">University of Strasbourg, 67412 Illkirch, France</nlm:aff></affiliation></author><author><name sortKey="Zeder Lutz, Gabrielle" sort="Zeder Lutz, Gabrielle" uniqKey="Zeder Lutz G" first="Gabrielle" last="Zeder-Lutz">Gabrielle Zeder-Lutz</name><affiliation><nlm:aff id="A10">University of Strasbourg, 67412 Illkirch, France</nlm:aff></affiliation></author><author><name sortKey="Schoenemann, Andreas" sort="Schoenemann, Andreas" uniqKey="Schoenemann A" first="Andreas" last="Schoenemann">Andreas Schoenemann</name><affiliation><nlm:aff id="A11">Merck KGaA, D-64293 Darmstadt, Germany</nlm:aff></affiliation></author><author><name sortKey="Clabbers, Anca" sort="Clabbers, Anca" uniqKey="Clabbers A" first="Anca" last="Clabbers">Anca Clabbers</name><affiliation><nlm:aff id="A12">Abbott Bioresearch Center, Worcester, MA 01605, USA</nlm:aff></affiliation></author><author><name sortKey="Wieckowski, Sebastien" sort="Wieckowski, Sebastien" uniqKey="Wieckowski S" first="Sebastien" last="Wieckowski">Sebastien Wieckowski</name><affiliation><nlm:aff id="A13">Institute of Molecular and Cellular Biology, University of Strasbourg, 67084 Strasbourg, France</nlm:aff></affiliation></author><author><name sortKey="Murphy, Mary M" sort="Murphy, Mary M" uniqKey="Murphy M" first="Mary M." last="Murphy">Mary M. Murphy</name><affiliation><nlm:aff id="A14">Reichert, Depew, NY 14043, USA</nlm:aff></affiliation></author><author><name sortKey="Page, Phillip" sort="Page, Phillip" uniqKey="Page P" first="Phillip" last="Page">Phillip Page</name><affiliation><nlm:aff id="A14">Reichert, Depew, NY 14043, USA</nlm:aff></affiliation></author><author><name sortKey="Ryan, Thomas E" sort="Ryan, Thomas E" uniqKey="Ryan T" first="Thomas E." last="Ryan">Thomas E. Ryan</name><affiliation><nlm:aff id="A14">Reichert, Depew, NY 14043, USA</nlm:aff></affiliation></author><author><name sortKey="Duffner, Jay" sort="Duffner, Jay" uniqKey="Duffner J" first="Jay" last="Duffner">Jay Duffner</name><affiliation><nlm:aff id="A15">Momenta Pharmaceuticals, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Ganguly, Tanmoy" sort="Ganguly, Tanmoy" uniqKey="Ganguly T" first="Tanmoy" last="Ganguly">Tanmoy Ganguly</name><affiliation><nlm:aff id="A15">Momenta Pharmaceuticals, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Corbin, John" sort="Corbin, John" uniqKey="Corbin J" first="John" last="Corbin">John Corbin</name><affiliation><nlm:aff id="A16">XOMA (U.S.), Emeryville, CA 94608, USA</nlm:aff></affiliation></author><author><name sortKey="Gautam, Satyen" sort="Gautam, Satyen" uniqKey="Gautam S" first="Satyen" last="Gautam">Satyen Gautam</name><affiliation><nlm:aff id="A17">Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 119260, Singapore</nlm:aff></affiliation></author><author><name sortKey="Anderluh, Gregor" sort="Anderluh, Gregor" uniqKey="Anderluh G" first="Gregor" last="Anderluh">Gregor Anderluh</name><affiliation><nlm:aff id="A18">Department of Biology, University of Ljubljiana, 1000 Ljubljiana, Slovenia</nlm:aff></affiliation></author><author><name sortKey="Bavdek, Andrej" sort="Bavdek, Andrej" uniqKey="Bavdek A" first="Andrej" last="Bavdek">Andrej Bavdek</name><affiliation><nlm:aff id="A18">Department of Biology, University of Ljubljiana, 1000 Ljubljiana, Slovenia</nlm:aff></affiliation></author><author><name sortKey="Reichmann, Dana" sort="Reichmann, Dana" uniqKey="Reichmann D" first="Dana" last="Reichmann">Dana Reichmann</name><affiliation><nlm:aff id="A19">Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel</nlm:aff></affiliation></author><author><name sortKey="Yadav, Satya P" sort="Yadav, Satya P" uniqKey="Yadav S" first="Satya P." last="Yadav">Satya P. Yadav</name><affiliation><nlm:aff id="A20">Molecular Biotechnology Core Laboratory, Cleveland Clinic Foundation, Cleveland, OH 44195, USA</nlm:aff></affiliation></author><author><name sortKey="Hommema, Eric" sort="Hommema, Eric" uniqKey="Hommema E" first="Eric" last="Hommema">Eric Hommema</name><affiliation><nlm:aff id="A21">ThermoFisher Scientific, Rockford, IL 61101, USA</nlm:aff></affiliation></author><author><name sortKey="Pol, Ewa" sort="Pol, Ewa" uniqKey="Pol E" first="Ewa" last="Pol">Ewa Pol</name><affiliation><nlm:aff id="A22">Biacore/GE Healthcare, SE-754 50 Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Drake, Andrew" sort="Drake, Andrew" uniqKey="Drake A" first="Andrew" last="Drake">Andrew Drake</name><affiliation><nlm:aff id="A23">AstraZeneca, Hayward, CA 94545, USA</nlm:aff></affiliation></author><author><name sortKey="Klakamp, Scott" sort="Klakamp, Scott" uniqKey="Klakamp S" first="Scott" last="Klakamp">Scott Klakamp</name><affiliation><nlm:aff id="A23">AstraZeneca, Hayward, CA 94545, USA</nlm:aff></affiliation></author><author><name sortKey="Chapman, Trevor" sort="Chapman, Trevor" uniqKey="Chapman T" first="Trevor" last="Chapman">Trevor Chapman</name><affiliation><nlm:aff id="A24">Neurodegeneration Research Department, GlaxoSmithKline, Harlow CM19 5AW, UK</nlm:aff></affiliation></author><author><name sortKey="Kernaghan, Dawn" sort="Kernaghan, Dawn" uniqKey="Kernaghan D" first="Dawn" last="Kernaghan">Dawn Kernaghan</name><affiliation><nlm:aff id="A25">MedImmune, Gaithersburg, MD 20878, USA</nlm:aff></affiliation></author><author><name sortKey="Miller, Ken" sort="Miller, Ken" uniqKey="Miller K" first="Ken" last="Miller">Ken Miller</name><affiliation><nlm:aff id="A25">MedImmune, Gaithersburg, MD 20878, USA</nlm:aff></affiliation></author><author><name sortKey="Schuman, Jason" sort="Schuman, Jason" uniqKey="Schuman J" first="Jason" last="Schuman">Jason Schuman</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Lindquist, Kevin" sort="Lindquist, Kevin" uniqKey="Lindquist K" first="Kevin" last="Lindquist">Kevin Lindquist</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Herlihy, Kara" sort="Herlihy, Kara" uniqKey="Herlihy K" first="Kara" last="Herlihy">Kara Herlihy</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Murphy, Michael B" sort="Murphy, Michael B" uniqKey="Murphy M" first="Michael B." last="Murphy">Michael B. Murphy</name><affiliation><nlm:aff id="A26">Biacore/GE Healthcare, Piscataway, NJ 08854, USA</nlm:aff></affiliation></author><author><name sortKey="Bohnsack, Richard" sort="Bohnsack, Richard" uniqKey="Bohnsack R" first="Richard" last="Bohnsack">Richard Bohnsack</name><affiliation><nlm:aff id="A27">Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA</nlm:aff></affiliation></author><author><name sortKey="Andrien, Bruce" sort="Andrien, Bruce" uniqKey="Andrien B" first="Bruce" last="Andrien">Bruce Andrien</name><affiliation><nlm:aff id="A28">Alexion Pharmaceuticals, Cheshire, CT 06410, USA</nlm:aff></affiliation></author><author><name sortKey="Brandani, Pietro" sort="Brandani, Pietro" uniqKey="Brandani P" first="Pietro" last="Brandani">Pietro Brandani</name><affiliation><nlm:aff id="A29">Applied Biosystems, Foster City, CA 94404, USA</nlm:aff></affiliation></author><author><name sortKey="Terwey, Danny" sort="Terwey, Danny" uniqKey="Terwey D" first="Danny" last="Terwey">Danny Terwey</name><affiliation><nlm:aff id="A30">diaDexus, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Millican, Rohn" sort="Millican, Rohn" uniqKey="Millican R" first="Rohn" last="Millican">Rohn Millican</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Darling, Ryan J" sort="Darling, Ryan J" uniqKey="Darling R" first="Ryan J." last="Darling">Ryan J. Darling</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Liann" sort="Wang, Liann" uniqKey="Wang L" first="Liann" last="Wang">Liann Wang</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Carter, Quincy" sort="Carter, Quincy" uniqKey="Carter Q" first="Quincy" last="Carter">Quincy Carter</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Dotzlaf, Joe" sort="Dotzlaf, Joe" uniqKey="Dotzlaf J" first="Joe" last="Dotzlaf">Joe Dotzlaf</name><affiliation><nlm:aff id="A31">Eli Lilly, Indianapolis, IN 46285, USA</nlm:aff></affiliation></author><author><name sortKey="Lopez Sagaseta, Jacinto" sort="Lopez Sagaseta, Jacinto" uniqKey="Lopez Sagaseta J" first="Jacinto" last="Lopez-Sagaseta">Jacinto Lopez-Sagaseta</name><affiliation><nlm:aff id="A32">Laboratory of Thrombosis and Haemostasis, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain</nlm:aff></affiliation></author><author><name sortKey="Campbell, Islay" sort="Campbell, Islay" uniqKey="Campbell I" first="Islay" last="Campbell">Islay Campbell</name><affiliation><nlm:aff id="A33">EMD Lexigen Research Center, Billerica, MA 01821, USA</nlm:aff></affiliation></author><author><name sortKey="Torreri, Paola" sort="Torreri, Paola" uniqKey="Torreri P" first="Paola" last="Torreri">Paola Torreri</name><affiliation><nlm:aff id="A34">Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Hoos, Sylviane" sort="Hoos, Sylviane" uniqKey="Hoos S" first="Sylviane" last="Hoos">Sylviane Hoos</name><affiliation><nlm:aff id="A35">Department of Structural Biology and Chemistry, Pasteur Institute, 75724 Paris, France</nlm:aff></affiliation></author><author><name sortKey="England, Patrick" sort="England, Patrick" uniqKey="England P" first="Patrick" last="England">Patrick England</name><affiliation><nlm:aff id="A35">Department of Structural Biology and Chemistry, Pasteur Institute, 75724 Paris, France</nlm:aff></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation><nlm:aff id="A36">Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA</nlm:aff></affiliation></author><author><name sortKey="Abdiche, Yasmina" sort="Abdiche, Yasmina" uniqKey="Abdiche Y" first="Yasmina" last="Abdiche">Yasmina Abdiche</name><affiliation><nlm:aff id="A37">Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Malashock, Daniel" sort="Malashock, Daniel" uniqKey="Malashock D" first="Daniel" last="Malashock">Daniel Malashock</name><affiliation><nlm:aff id="A37">Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Pinkerton, Alanna" sort="Pinkerton, Alanna" uniqKey="Pinkerton A" first="Alanna" last="Pinkerton">Alanna Pinkerton</name><affiliation><nlm:aff id="A37">Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</nlm:aff></affiliation></author><author><name sortKey="Wong, Melanie" sort="Wong, Melanie" uniqKey="Wong M" first="Melanie" last="Wong">Melanie Wong</name><affiliation><nlm:aff id="A38">PDL BioPharma, Fremont, CA 94555, USA</nlm:aff></affiliation></author><author><name sortKey="Lafer, Eileen" sort="Lafer, Eileen" uniqKey="Lafer E" first="Eileen" last="Lafer">Eileen Lafer</name><affiliation><nlm:aff id="A39">Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA</nlm:aff></affiliation></author><author><name sortKey="Hinck, Cynthia" sort="Hinck, Cynthia" uniqKey="Hinck C" first="Cynthia" last="Hinck">Cynthia Hinck</name><affiliation><nlm:aff id="A39">Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA</nlm:aff></affiliation></author><author><name sortKey="Thompson, Kevin" sort="Thompson, Kevin" uniqKey="Thompson K" first="Kevin" last="Thompson">Kevin Thompson</name><affiliation><nlm:aff id="A40">Akubio, Cambridge CB4 0GJ, UK</nlm:aff></affiliation></author><author><name sortKey="Primo, Carmelo Di" sort="Primo, Carmelo Di" uniqKey="Primo C" first="Carmelo Di" last="Primo">Carmelo Di Primo</name><affiliation><nlm:aff id="A41">INSERM U869, Institut Europeen de Chimie et Biologie, University of Bordeaux, 33607 Pessac, France</nlm:aff></affiliation></author><author><name sortKey="Joyce, Alison" sort="Joyce, Alison" uniqKey="Joyce A" first="Alison" last="Joyce">Alison Joyce</name><affiliation><nlm:aff id="A42">Wyeth Research, Cambridge, MA 02140, USA</nlm:aff></affiliation></author><author><name sortKey="Brooks, Jonathan" sort="Brooks, Jonathan" uniqKey="Brooks J" first="Jonathan" last="Brooks">Jonathan Brooks</name><affiliation><nlm:aff id="A42">Wyeth Research, Cambridge, MA 02140, USA</nlm:aff></affiliation></author><author><name sortKey="Torta, Federico" sort="Torta, Federico" uniqKey="Torta F" first="Federico" last="Torta">Federico Torta</name><affiliation><nlm:aff id="A43">Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark</nlm:aff></affiliation></author><author><name sortKey="Bagge Hagel, Anne Birgitte" sort="Bagge Hagel, Anne Birgitte" uniqKey="Bagge Hagel A" first="Anne Birgitte" last="Bagge Hagel">Anne Birgitte Bagge Hagel</name><affiliation><nlm:aff id="A44">NovoNordisk, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Krarup, Janus" sort="Krarup, Janus" uniqKey="Krarup J" first="Janus" last="Krarup">Janus Krarup</name><affiliation><nlm:aff id="A44">NovoNordisk, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Pass, Jesper" sort="Pass, Jesper" uniqKey="Pass J" first="Jesper" last="Pass">Jesper Pass</name><affiliation><nlm:aff id="A44">NovoNordisk, 2820 Gentofte, Denmark</nlm:aff></affiliation></author><author><name sortKey="Ferreira, Monica" sort="Ferreira, Monica" uniqKey="Ferreira M" first="Monica" last="Ferreira">Monica Ferreira</name><affiliation><nlm:aff id="A45">Södertörns University College, 14152 Huddinge, Sweden</nlm:aff></affiliation></author><author><name sortKey="Shikov, Sergei" sort="Shikov, Sergei" uniqKey="Shikov S" first="Sergei" last="Shikov">Sergei Shikov</name><affiliation><nlm:aff id="A46">Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA</nlm:aff></affiliation></author><author><name sortKey="Mikolajczyk, Malgorzata" sort="Mikolajczyk, Malgorzata" uniqKey="Mikolajczyk M" first="Malgorzata" last="Mikolajczyk">Malgorzata Mikolajczyk</name><affiliation><nlm:aff id="A47">U.S. Food and Drug Administration, Bethesda, MD 20892, USA</nlm:aff></affiliation></author><author><name sortKey="Abe, Yuki" sort="Abe, Yuki" uniqKey="Abe Y" first="Yuki" last="Abe">Yuki Abe</name><affiliation><nlm:aff id="A48">Department of Biochemical Engineering, University College London, London WC1E 7JE, UK</nlm:aff></affiliation></author><author><name sortKey="Barbato, Gaetano" sort="Barbato, Gaetano" uniqKey="Barbato G" first="Gaetano" last="Barbato">Gaetano Barbato</name><affiliation><nlm:aff id="A49">Merck, 00040 Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Giannetti, Anthony M" sort="Giannetti, Anthony M" uniqKey="Giannetti A" first="Anthony M." last="Giannetti">Anthony M. Giannetti</name><affiliation><nlm:aff id="A50">Roche, Palo Alto, CA 94304, USA</nlm:aff></affiliation></author><author><name sortKey="Krishnamoorthy, Ganeshram" sort="Krishnamoorthy, Ganeshram" uniqKey="Krishnamoorthy G" first="Ganeshram" last="Krishnamoorthy">Ganeshram Krishnamoorthy</name><affiliation><nlm:aff id="A51">University of Twente, 7500AE Enschede, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Beusink, Bianca" sort="Beusink, Bianca" uniqKey="Beusink B" first="Bianca" last="Beusink">Bianca Beusink</name><affiliation><nlm:aff id="A51">University of Twente, 7500AE Enschede, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Satpaev, Daulet" sort="Satpaev, Daulet" uniqKey="Satpaev D" first="Daulet" last="Satpaev">Daulet Satpaev</name><affiliation><nlm:aff id="A52">Agensys, Santa Monica, CA 90404, USA</nlm:aff></affiliation></author><author><name sortKey="Tsang, Tiffany" sort="Tsang, Tiffany" uniqKey="Tsang T" first="Tiffany" last="Tsang">Tiffany Tsang</name><affiliation><nlm:aff id="A53">Novartis, Emeryville, CA 94608, USA</nlm:aff></affiliation></author><author><name sortKey="Fang, Eric" sort="Fang, Eric" uniqKey="Fang E" first="Eric" last="Fang">Eric Fang</name><affiliation><nlm:aff id="A53">Novartis, Emeryville, CA 94608, USA</nlm:aff></affiliation></author><author><name sortKey="Partridge, James" sort="Partridge, James" uniqKey="Partridge J" first="James" last="Partridge">James Partridge</name><affiliation><nlm:aff id="A54">Massachusetts Institute of Technology, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Brohawn, Stephen" sort="Brohawn, Stephen" uniqKey="Brohawn S" first="Stephen" last="Brohawn">Stephen Brohawn</name><affiliation><nlm:aff id="A54">Massachusetts Institute of Technology, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Horn, James" sort="Horn, James" uniqKey="Horn J" first="James" last="Horn">James Horn</name><affiliation><nlm:aff id="A55">Northern Illinois University, DeKalb, IL 60115, USA</nlm:aff></affiliation></author><author><name sortKey="Pritsch, Otto" sort="Pritsch, Otto" uniqKey="Pritsch O" first="Otto" last="Pritsch">Otto Pritsch</name><affiliation><nlm:aff id="A56">Pasteur Institute of Montevideo, CP 11400 Montevideo, Uruguay</nlm:aff></affiliation></author><author><name sortKey="Obal, Gonzalo" sort="Obal, Gonzalo" uniqKey="Obal G" first="Gonzalo" last="Obal">Gonzalo Obal</name><affiliation><nlm:aff id="A56">Pasteur Institute of Montevideo, CP 11400 Montevideo, Uruguay</nlm:aff></affiliation></author><author><name sortKey="Nilapwar, Sanjay" sort="Nilapwar, Sanjay" uniqKey="Nilapwar S" first="Sanjay" last="Nilapwar">Sanjay Nilapwar</name><affiliation><nlm:aff id="A57">University of Manchester, Manchester M1 7ND, UK</nlm:aff></affiliation></author><author><name sortKey="Busby, Ben" sort="Busby, Ben" uniqKey="Busby B" first="Ben" last="Busby">Ben Busby</name><affiliation><nlm:aff id="A58">Department of Physiology, University of Maryland, Baltimore, MD 21201, USA</nlm:aff></affiliation></author><author><name sortKey="Gutierrez Sanchez, Gerardo" sort="Gutierrez Sanchez, Gerardo" uniqKey="Gutierrez Sanchez G" first="Gerardo" last="Gutierrez-Sanchez">Gerardo Gutierrez-Sanchez</name><affiliation><nlm:aff id="A59">Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA</nlm:aff></affiliation></author><author><name sortKey="Gupta, Ruchira Das" sort="Gupta, Ruchira Das" uniqKey="Gupta R" first="Ruchira Das" last="Gupta">Ruchira Das Gupta</name><affiliation><nlm:aff id="A60">Adnexus Therapeutics, Waltham, MA 02453, USA</nlm:aff></affiliation></author><author><name sortKey="Canepa, Sylvie" sort="Canepa, Sylvie" uniqKey="Canepa S" first="Sylvie" last="Canepa">Sylvie Canepa</name><affiliation><nlm:aff id="A61">University of Tours, 37380 Nouzilly, France</nlm:aff></affiliation></author><author><name sortKey="Witte, Krista" sort="Witte, Krista" uniqKey="Witte K" first="Krista" last="Witte">Krista Witte</name><affiliation><nlm:aff id="A62">ForteBio, Menlo Park, CA 94025, USA</nlm:aff></affiliation></author><author><name sortKey="Nikolovska Coleska, Zaneta" sort="Nikolovska Coleska, Zaneta" uniqKey="Nikolovska Coleska Z" first="Zaneta" last="Nikolovska-Coleska">Zaneta Nikolovska-Coleska</name><affiliation><nlm:aff id="A63">University of Michigan, Ann Arbor, MI 48109, USA</nlm:aff></affiliation></author><author><name sortKey="Cho, Yun Hee" sort="Cho, Yun Hee" uniqKey="Cho Y" first="Yun Hee" last="Cho">Yun Hee Cho</name><affiliation><nlm:aff id="A64">Human Genome Sciences, Rockville, MD 20850, USA</nlm:aff></affiliation></author><author><name sortKey="D Gata, Roberta" sort="D Gata, Roberta" uniqKey="D Gata R" first="Roberta" last="D Gata">Roberta D Gata</name><affiliation><nlm:aff id="A65">Department of Chemical Sciences, University of Catania, 95125 Catania, Italy</nlm:aff></affiliation></author><author><name sortKey="Schlick, Kristian" sort="Schlick, Kristian" uniqKey="Schlick K" first="Kristian" last="Schlick">Kristian Schlick</name><affiliation><nlm:aff id="A66">Montana State University, Bozeman, MT 59717, USA</nlm:aff></affiliation></author><author><name sortKey="Calvert, Rosy" sort="Calvert, Rosy" uniqKey="Calvert R" first="Rosy" last="Calvert">Rosy Calvert</name><affiliation><nlm:aff id="A67">GKT School of Biomedical Sciences, London SE1 1UL, UK</nlm:aff></affiliation></author><author><name sortKey="Munoz, Eva M" sort="Munoz, Eva M" uniqKey="Munoz E" first="Eva M." last="Munoz">Eva M. Munoz</name><affiliation><nlm:aff id="A68">Organic and Pharmaceutical Chemistry Department, Complutense University, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Hernaiz, Maria Jose" sort="Hernaiz, Maria Jose" uniqKey="Hernaiz M" first="Maria Jose" last="Hernaiz">Maria Jose Hernaiz</name><affiliation><nlm:aff id="A68">Organic and Pharmaceutical Chemistry Department, Complutense University, 28040 Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Bravman, Tsafir" sort="Bravman, Tsafir" uniqKey="Bravman T" first="Tsafir" last="Bravman">Tsafir Bravman</name><affiliation><nlm:aff id="A69">Bio-Rad Haifa, 32000 Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Dines, Monica" sort="Dines, Monica" uniqKey="Dines M" first="Monica" last="Dines">Monica Dines</name><affiliation><nlm:aff id="A69">Bio-Rad Haifa, 32000 Haifa, Israel</nlm:aff></affiliation></author><author><name sortKey="Yang, Min Hsiang" sort="Yang, Min Hsiang" uniqKey="Yang M" first="Min-Hsiang" last="Yang">Min-Hsiang Yang</name><affiliation><nlm:aff id="A70">Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan</nlm:aff></affiliation></author><author><name sortKey="Puskas, Agnes" sort="Puskas, Agnes" uniqKey="Puskas A" first="Agnes" last="Puskas">Agnes Puskas</name><affiliation><nlm:aff id="A71">University of Texas Medical School at Houston, Houston, TX 77030, USA</nlm:aff></affiliation></author><author><name sortKey="Boni, Erica" sort="Boni, Erica" uniqKey="Boni E" first="Erica" last="Boni">Erica Boni</name><affiliation><nlm:aff id="A72">Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Jiejin" sort="Li, Jiejin" uniqKey="Li J" first="Jiejin" last="Li">Jiejin Li</name><affiliation><nlm:aff id="A73">Division of Molecular Structure, National Institute of Medical Research (UK), London NW7 1AA, UK</nlm:aff></affiliation></author><author><name sortKey="Wear, Martin" sort="Wear, Martin" uniqKey="Wear M" first="Martin" last="Wear">Martin Wear</name><affiliation><nlm:aff id="A74">Centre for Translational and Chemical Biology, Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK</nlm:aff></affiliation></author><author><name sortKey="Grinberg, Asya" sort="Grinberg, Asya" uniqKey="Grinberg A" first="Asya" last="Grinberg">Asya Grinberg</name><affiliation><nlm:aff id="A75">Acceleron Pharma, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Baardsnes, Jason" sort="Baardsnes, Jason" uniqKey="Baardsnes J" first="Jason" last="Baardsnes">Jason Baardsnes</name><affiliation><nlm:aff id="A76">National Research Council (Canada), Biotechnology Research Institute, Montreal, Que., Canada H4P 2R2</nlm:aff></affiliation></author><author><name sortKey="Dolezal, Olan" sort="Dolezal, Olan" uniqKey="Dolezal O" first="Olan" last="Dolezal">Olan Dolezal</name><affiliation><nlm:aff id="A77">CSIRO Health Sciences and Nutrition, Parkville, VIC 3052, Australia</nlm:aff></affiliation></author><author><name sortKey="Gainey, Melicia" sort="Gainey, Melicia" uniqKey="Gainey M" first="Melicia" last="Gainey">Melicia Gainey</name><affiliation><nlm:aff id="A78">Battelle Biomedical Research Center, Columbus, OH 43201, USA</nlm:aff></affiliation></author><author><name sortKey="Anderson, Henrik" sort="Anderson, Henrik" uniqKey="Anderson H" first="Henrik" last="Anderson">Henrik Anderson</name><affiliation><nlm:aff id="A79">Attana AB, SE-113 47 Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Peng, Jinlin" sort="Peng, Jinlin" uniqKey="Peng J" first="Jinlin" last="Peng">Jinlin Peng</name><affiliation><nlm:aff id="A80">Corning, Corning, NY 14831, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Mark" sort="Lewis, Mark" uniqKey="Lewis M" first="Mark" last="Lewis">Mark Lewis</name><affiliation><nlm:aff id="A80">Corning, Corning, NY 14831, USA</nlm:aff></affiliation></author><author><name sortKey="Spies, Peter" sort="Spies, Peter" uniqKey="Spies P" first="Peter" last="Spies">Peter Spies</name><affiliation><nlm:aff id="A81">School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland, CH-4132 Muttenz, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Trinh, Quyhn" sort="Trinh, Quyhn" uniqKey="Trinh Q" first="Quyhn" last="Trinh">Quyhn Trinh</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Bibikov, Sergei" sort="Bibikov, Sergei" uniqKey="Bibikov S" first="Sergei" last="Bibikov">Sergei Bibikov</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Raymond, Jill" sort="Raymond, Jill" uniqKey="Raymond J" first="Jill" last="Raymond">Jill Raymond</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Yousef, Mohammed" sort="Yousef, Mohammed" uniqKey="Yousef M" first="Mohammed" last="Yousef">Mohammed Yousef</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Chandrasekaran, Vidya" sort="Chandrasekaran, Vidya" uniqKey="Chandrasekaran V" first="Vidya" last="Chandrasekaran">Vidya Chandrasekaran</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Feng, Yuguo" sort="Feng, Yuguo" uniqKey="Feng Y" first="Yuguo" last="Feng">Yuguo Feng</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Emerick, Anne" sort="Emerick, Anne" uniqKey="Emerick A" first="Anne" last="Emerick">Anne Emerick</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Mundodo, Suparna" sort="Mundodo, Suparna" uniqKey="Mundodo S" first="Suparna" last="Mundodo">Suparna Mundodo</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Guimaraes, Rejane" sort="Guimaraes, Rejane" uniqKey="Guimaraes R" first="Rejane" last="Guimaraes">Rejane Guimaraes</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Mcgirr, Katy" sort="Mcgirr, Katy" uniqKey="Mcgirr K" first="Katy" last="Mcgirr">Katy Mcgirr</name><affiliation><nlm:aff id="A82">Bio-Rad, Hercules, CA 94547, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Yue Ji" sort="Li, Yue Ji" uniqKey="Li Y" first="Yue-Ji" last="Li">Yue-Ji Li</name><affiliation><nlm:aff id="A83">Monsanto, Chesterfield, MO 63198, USA</nlm:aff></affiliation></author><author><name sortKey="Hughes, Heather" sort="Hughes, Heather" uniqKey="Hughes H" first="Heather" last="Hughes">Heather Hughes</name><affiliation><nlm:aff id="A84">Genzyme, Cambridge, MA 02142, USA</nlm:aff></affiliation></author><author><name sortKey="Mantz, Hubert" sort="Mantz, Hubert" uniqKey="Mantz H" first="Hubert" last="Mantz">Hubert Mantz</name><affiliation><nlm:aff id="A85">Saarland University, D-66041 Saarbrücken, Germany</nlm:aff></affiliation></author><author><name sortKey="Skrabana, Rostislav" sort="Skrabana, Rostislav" uniqKey="Skrabana R" first="Rostislav" last="Skrabana">Rostislav Skrabana</name><affiliation><nlm:aff id="A86">Institute of Neuroimmunology of SAS, 84510 Bratislava, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Witmer, Mark" sort="Witmer, Mark" uniqKey="Witmer M" first="Mark" last="Witmer">Mark Witmer</name><affiliation><nlm:aff id="A87">Bristol–Myers Squibb, Princeton, NJ 08543, USA</nlm:aff></affiliation></author><author><name sortKey="Ballard, Joshua" sort="Ballard, Joshua" uniqKey="Ballard J" first="Joshua" last="Ballard">Joshua Ballard</name><affiliation><nlm:aff id="A88">Array Biopharma, Boulder, CO 80301, USA</nlm:aff></affiliation></author><author><name sortKey="Martin, Loic" sort="Martin, Loic" uniqKey="Martin L" first="Loic" last="Martin">Loic Martin</name><affiliation><nlm:aff id="A89">CEA, iBiTecs, Service d’Ingénierie Moléculaire des Protéines, 91191 Gif sur Yvette, France</nlm:aff></affiliation></author><author><name sortKey="Skladal, Petr" sort="Skladal, Petr" uniqKey="Skladal P" first="Petr" last="Skladal">Petr Skladal</name><affiliation><nlm:aff id="A90">Department of Biochemistry, Masaryk University, 61137 Brno, Czech Republic</nlm:aff></affiliation></author><author><name sortKey="Korza, George" sort="Korza, George" uniqKey="Korza G" first="George" last="Korza">George Korza</name><affiliation><nlm:aff id="A91">University of Connecticut Health Center, Farmington, CT 06030, USA</nlm:aff></affiliation></author><author><name sortKey="Laird Offringa, Ite" sort="Laird Offringa, Ite" uniqKey="Laird Offringa I" first="Ite" last="Laird-Offringa">Ite Laird-Offringa</name><affiliation><nlm:aff id="A92">University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Lee, Charlene S" sort="Lee, Charlene S" uniqKey="Lee C" first="Charlene S." last="Lee">Charlene S. Lee</name><affiliation><nlm:aff id="A92">University of Southern California, Los Angeles, CA 90033, USA</nlm:aff></affiliation></author><author><name sortKey="Khadir, Abdelkrim" sort="Khadir, Abdelkrim" uniqKey="Khadir A" first="Abdelkrim" last="Khadir">Abdelkrim Khadir</name><affiliation><nlm:aff id="A93">GeminX Biotechnologies, Montreal, Que., Canada H2X 2H7</nlm:aff></affiliation></author><author><name sortKey="Podlaski, Frank" sort="Podlaski, Frank" uniqKey="Podlaski F" first="Frank" last="Podlaski">Frank Podlaski</name><affiliation><nlm:aff id="A94">Hoffman–La Roche, Nutley, NJ 07110, USA</nlm:aff></affiliation></author><author><name sortKey="Neuner, Phillippe" sort="Neuner, Phillippe" uniqKey="Neuner P" first="Phillippe" last="Neuner">Phillippe Neuner</name><affiliation><nlm:aff id="A95">IRBM, Pomezia, 00040 Rome, Italy</nlm:aff></affiliation></author><author><name sortKey="Rothacker, Julie" sort="Rothacker, Julie" uniqKey="Rothacker J" first="Julie" last="Rothacker">Julie Rothacker</name><affiliation><nlm:aff id="A96">Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia</nlm:aff></affiliation></author><author><name sortKey="Rafique, Ashique" sort="Rafique, Ashique" uniqKey="Rafique A" first="Ashique" last="Rafique">Ashique Rafique</name><affiliation><nlm:aff id="A97">Regeneron, Tarrytown, NY 10591, USA</nlm:aff></affiliation></author><author><name sortKey="Dankbar, Nico" sort="Dankbar, Nico" uniqKey="Dankbar N" first="Nico" last="Dankbar">Nico Dankbar</name><affiliation><nlm:aff id="A98">University of Muenster, D-48149 Muenster, Germany</nlm:aff></affiliation></author><author><name sortKey="Kainz, Peter" sort="Kainz, Peter" uniqKey="Kainz P" first="Peter" last="Kainz">Peter Kainz</name><affiliation><nlm:aff id="A99">Department of Molecular Biology, University of Salzburg, A-5020 Salzburg, Austria</nlm:aff></affiliation></author><author><name sortKey="Gedig, Erk" sort="Gedig, Erk" uniqKey="Gedig E" first="Erk" last="Gedig">Erk Gedig</name><affiliation><nlm:aff id="A100">XanTec Bioanalytics, D-48149 Muenster, Germany</nlm:aff></affiliation></author><author><name sortKey="Vuyisich, Momchilo" sort="Vuyisich, Momchilo" uniqKey="Vuyisich M" first="Momchilo" last="Vuyisich">Momchilo Vuyisich</name><affiliation><nlm:aff id="A101">Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA</nlm:aff></affiliation></author><author><name sortKey="Boozer, Christina" sort="Boozer, Christina" uniqKey="Boozer C" first="Christina" last="Boozer">Christina Boozer</name><affiliation><nlm:aff id="A102">Lumera, Bothell, WA 98011, USA</nlm:aff></affiliation></author><author><name sortKey="Ly, Nguyen" sort="Ly, Nguyen" uniqKey="Ly N" first="Nguyen" last="Ly">Nguyen Ly</name><affiliation><nlm:aff id="A103">Arizona State University, Tempe, AZ 85287, USA</nlm:aff></affiliation></author><author><name sortKey="Toews, Mark" sort="Toews, Mark" uniqKey="Toews M" first="Mark" last="Toews">Mark Toews</name><affiliation><nlm:aff id="A104">Dyax, Cambridge, MA 02139, USA</nlm:aff></affiliation></author><author><name sortKey="Uren, Aykut" sort="Uren, Aykut" uniqKey="Uren A" first="Aykut" last="Uren">Aykut Uren</name><affiliation><nlm:aff id="A105">Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA</nlm:aff></affiliation></author><author><name sortKey="Kalyuzhniy, Oleksandr" sort="Kalyuzhniy, Oleksandr" uniqKey="Kalyuzhniy O" first="Oleksandr" last="Kalyuzhniy">Oleksandr Kalyuzhniy</name><affiliation><nlm:aff id="A106">Department of Biochemistry, University of Washington, Seattle, WA 98195, USA</nlm:aff></affiliation></author><author><name sortKey="Lewis, Kenneth" sort="Lewis, Kenneth" uniqKey="Lewis K" first="Kenneth" last="Lewis">Kenneth Lewis</name><affiliation><nlm:aff id="A107">Zymogenetics, Seattle, WA 98102, USA</nlm:aff></affiliation></author><author><name sortKey="Chomey, Eugene" sort="Chomey, Eugene" uniqKey="Chomey E" first="Eugene" last="Chomey">Eugene Chomey</name><affiliation><nlm:aff id="A108">Bio-Rad Canada, Edmonton, Alta., Canada T6R 2W6</nlm:aff></affiliation></author><author><name sortKey="Pak, Brian J" sort="Pak, Brian J" uniqKey="Pak B" first="Brian J." last="Pak">Brian J. Pak</name><affiliation><nlm:aff id="A109">Bio-Rad Canada, Toronto, Ont., Canada</nlm:aff></affiliation></author><author><name sortKey="Myszka, David G" sort="Myszka, David G" uniqKey="Myszka D" first="David G." last="Myszka">David G. Myszka</name><affiliation><nlm:aff id="A1">Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Analytical biochemistry</title><idno type="ISSN">0003-2697</idno><idno type="eISSN">1096-0309</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione <italic>S</italic>-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0370535</journal-id><journal-id journal-id-type="pubmed-jr-id">518</journal-id><journal-id journal-id-type="nlm-ta">Anal Biochem</journal-id><journal-id journal-id-type="iso-abbrev">Anal. Biochem.</journal-id><journal-title-group><journal-title>Analytical biochemistry</journal-title></journal-title-group><issn pub-type="ppub">0003-2697</issn><issn pub-type="epub">1096-0309</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19133223</article-id><article-id pub-id-type="pmc">3793259</article-id><article-id pub-id-type="doi">10.1016/j.ab.2008.11.021</article-id><article-id pub-id-type="manuscript">NIHMS500790</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>A global benchmark study using affinity-based biosensors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rich</surname><given-names>Rebecca L.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Papalia</surname><given-names>Giuseppe A.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Flynn</surname><given-names>Peter J.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Furneisen</surname><given-names>Jamie</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Quinn</surname><given-names>John</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Klein</surname><given-names>Joshua S.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Katsamba</surname><given-names>Phini S.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Waddell</surname><given-names>M. 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contrib-type="author"><name><surname>Chomey</surname><given-names>Eugene</given-names></name><xref ref-type="aff" rid="A108">dd</xref></contrib><contrib contrib-type="author"><name><surname>Pak</surname><given-names>Brian J.</given-names></name><xref ref-type="aff" rid="A109">de</xref></contrib><contrib contrib-type="author"><name><surname>Myszka</surname><given-names>David G.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA</aff><aff id="A2"><label>b</label>KaloBios Pharmaceuticals, South San Francisco, CA 94080, USA</aff><aff id="A3"><label>c</label>Schering–Plough Biopharma, Palo Alto, CA 94304, USA</aff><aff id="A4"><label>d</label>Nomadics, Oklahoma City, OK 73104, USA</aff><aff id="A5"><label>e</label>Biochemistry and Molecular Biophysics, California Institute of Technology, Pasadena, CA 91125, USA</aff><aff id="A6"><label>f</label>Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA</aff><aff id="A7"><label>g</label>Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA</aff><aff id="A8"><label>h</label>University of Zurich, CH-8057 Zurich, Switzerland</aff><aff id="A9"><label>i</label>Molecular Probes/Invitrogen, Eugene, OR 97402, USA</aff><aff id="A10"><label>j</label>University of Strasbourg, 67412 Illkirch, France</aff><aff id="A11"><label>k</label>Merck KGaA, D-64293 Darmstadt, Germany</aff><aff id="A12"><label>l</label>Abbott Bioresearch Center, Worcester, MA 01605, USA</aff><aff id="A13"><label>m</label>Institute of Molecular and Cellular Biology, University of Strasbourg, 67084 Strasbourg, France</aff><aff id="A14"><label>n</label>Reichert, Depew, NY 14043, USA</aff><aff id="A15"><label>o</label>Momenta Pharmaceuticals, Cambridge, MA 02142, USA</aff><aff id="A16"><label>p</label>XOMA (U.S.), Emeryville, CA 94608, USA</aff><aff id="A17"><label>q</label>Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 119260, Singapore</aff><aff id="A18"><label>r</label>Department of Biology, University of Ljubljiana, 1000 Ljubljiana, Slovenia</aff><aff id="A19"><label>s</label>Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel</aff><aff id="A20"><label>t</label>Molecular Biotechnology Core Laboratory, Cleveland Clinic Foundation, Cleveland, OH 44195, USA</aff><aff id="A21"><label>u</label>ThermoFisher Scientific, Rockford, IL 61101, USA</aff><aff id="A22"><label>v</label>Biacore/GE Healthcare, SE-754 50 Uppsala, Sweden</aff><aff id="A23"><label>w</label>AstraZeneca, Hayward, CA 94545, USA</aff><aff id="A24"><label>x</label>Neurodegeneration Research Department, GlaxoSmithKline, Harlow CM19 5AW, UK</aff><aff id="A25"><label>y</label>MedImmune, Gaithersburg, MD 20878, USA</aff><aff id="A26"><label>z</label>Biacore/GE Healthcare, Piscataway, NJ 08854, USA</aff><aff id="A27"><label>aa</label>Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA</aff><aff id="A28"><label>ab</label>Alexion Pharmaceuticals, Cheshire, CT 06410, USA</aff><aff id="A29"><label>ac</label>Applied Biosystems, Foster City, CA 94404, USA</aff><aff id="A30"><label>ad</label>diaDexus, South San Francisco, CA 94080, USA</aff><aff id="A31"><label>ae</label>Eli Lilly, Indianapolis, IN 46285, USA</aff><aff id="A32"><label>af</label>Laboratory of Thrombosis and Haemostasis, Center for Applied Medical Research, University of Navarra, 31008 Pamplona, Spain</aff><aff id="A33"><label>ag</label>EMD Lexigen Research Center, Billerica, MA 01821, USA</aff><aff id="A34"><label>ah</label>Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, 00161 Rome, Italy</aff><aff id="A35"><label>ai</label>Department of Structural Biology and Chemistry, Pasteur Institute, 75724 Paris, France</aff><aff id="A36"><label>aj</label>Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA</aff><aff id="A37"><label>ak</label>Pfizer/Rinat Laboratories, South San Francisco, CA 94080, USA</aff><aff id="A38"><label>al</label>PDL BioPharma, Fremont, CA 94555, USA</aff><aff id="A39"><label>am</label>Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA</aff><aff id="A40"><label>an</label>Akubio, Cambridge CB4 0GJ, UK</aff><aff id="A41"><label>ao</label>INSERM U869, Institut Europeen de Chimie et Biologie, University of Bordeaux, 33607 Pessac, France</aff><aff id="A42"><label>ap</label>Wyeth Research, Cambridge, MA 02140, USA</aff><aff id="A43"><label>aq</label>Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark</aff><aff id="A44"><label>ar</label>NovoNordisk, 2820 Gentofte, Denmark</aff><aff id="A45"><label>as</label>Södertörns University College, 14152 Huddinge, Sweden</aff><aff id="A46"><label>at</label>Department of Biochemistry, Temple University, Philadelphia, PA 19140, USA</aff><aff id="A47"><label>au</label>U.S. Food and Drug Administration, Bethesda, MD 20892, USA</aff><aff id="A48"><label>av</label>Department of Biochemical Engineering, University College London, London WC1E 7JE, UK</aff><aff id="A49"><label>aw</label>Merck, 00040 Rome, Italy</aff><aff id="A50"><label>ax</label>Roche, Palo Alto, CA 94304, USA</aff><aff id="A51"><label>ay</label>University of Twente, 7500AE Enschede, The Netherlands</aff><aff id="A52"><label>az</label>Agensys, Santa Monica, CA 90404, USA</aff><aff id="A53"><label>ba</label>Novartis, Emeryville, CA 94608, USA</aff><aff id="A54"><label>bb</label>Massachusetts Institute of Technology, Cambridge, MA 02139, USA</aff><aff id="A55"><label>bc</label>Northern Illinois University, DeKalb, IL 60115, USA</aff><aff id="A56"><label>bd</label>Pasteur Institute of Montevideo, CP 11400 Montevideo, Uruguay</aff><aff id="A57"><label>be</label>University of Manchester, Manchester M1 7ND, UK</aff><aff id="A58"><label>bf</label>Department of Physiology, University of Maryland, Baltimore, MD 21201, USA</aff><aff id="A59"><label>bg</label>Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA</aff><aff id="A60"><label>bh</label>Adnexus Therapeutics, Waltham, MA 02453, USA</aff><aff id="A61"><label>bi</label>University of Tours, 37380 Nouzilly, France</aff><aff id="A62"><label>bj</label>ForteBio, Menlo Park, CA 94025, USA</aff><aff id="A63"><label>bk</label>University of Michigan, Ann Arbor, MI 48109, USA</aff><aff id="A64"><label>bl</label>Human Genome Sciences, Rockville, MD 20850, USA</aff><aff id="A65"><label>bm</label>Department of Chemical Sciences, University of Catania, 95125 Catania, Italy</aff><aff id="A66"><label>bn</label>Montana State University, Bozeman, MT 59717, USA</aff><aff id="A67"><label>bo</label>GKT School of Biomedical Sciences, London SE1 1UL, UK</aff><aff id="A68"><label>bp</label>Organic and Pharmaceutical Chemistry Department, Complutense University, 28040 Madrid, Spain</aff><aff id="A69"><label>bq</label>Bio-Rad Haifa, 32000 Haifa, Israel</aff><aff id="A70"><label>br</label>Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan</aff><aff id="A71"><label>bs</label>University of Texas Medical School at Houston, Houston, TX 77030, USA</aff><aff id="A72"><label>bt</label>Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA</aff><aff id="A73"><label>bu</label>Division of Molecular Structure, National Institute of Medical Research (UK), London NW7 1AA, UK</aff><aff id="A74"><label>bv</label>Centre for Translational and Chemical Biology, Institute of Structural and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK</aff><aff id="A75"><label>bw</label>Acceleron Pharma, Cambridge, MA 02139, USA</aff><aff id="A76"><label>bx</label>National Research Council (Canada), Biotechnology Research Institute, Montreal, Que., Canada H4P 2R2</aff><aff id="A77"><label>by</label>CSIRO Health Sciences and Nutrition, Parkville, VIC 3052, Australia</aff><aff id="A78"><label>bz</label>Battelle Biomedical Research Center, Columbus, OH 43201, USA</aff><aff id="A79"><label>ca</label>Attana AB, SE-113 47 Stockholm, Sweden</aff><aff id="A80"><label>cb</label>Corning, Corning, NY 14831, USA</aff><aff id="A81"><label>cc</label>School of Life Sciences, Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland, CH-4132 Muttenz, Switzerland</aff><aff id="A82"><label>cd</label>Bio-Rad, Hercules, CA 94547, USA</aff><aff id="A83"><label>ce</label>Monsanto, Chesterfield, MO 63198, USA</aff><aff id="A84"><label>cf</label>Genzyme, Cambridge, MA 02142, USA</aff><aff id="A85"><label>cg</label>Saarland University, D-66041 Saarbrücken, Germany</aff><aff id="A86"><label>ch</label>Institute of Neuroimmunology of SAS, 84510 Bratislava, Slovakia</aff><aff id="A87"><label>ci</label>Bristol–Myers Squibb, Princeton, NJ 08543, USA</aff><aff id="A88"><label>cj</label>Array Biopharma, Boulder, CO 80301, USA</aff><aff id="A89"><label>ck</label>CEA, iBiTecs, Service d’Ingénierie Moléculaire des Protéines, 91191 Gif sur Yvette, France</aff><aff id="A90"><label>cl</label>Department of Biochemistry, Masaryk University, 61137 Brno, Czech Republic</aff><aff id="A91"><label>cm</label>University of Connecticut Health Center, Farmington, CT 06030, USA</aff><aff id="A92"><label>cn</label>University of Southern California, Los Angeles, CA 90033, USA</aff><aff id="A93"><label>co</label>GeminX Biotechnologies, Montreal, Que., Canada H2X 2H7</aff><aff id="A94"><label>cp</label>Hoffman–La Roche, Nutley, NJ 07110, USA</aff><aff id="A95"><label>cq</label>IRBM, Pomezia, 00040 Rome, Italy</aff><aff id="A96"><label>cr</label>Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Vic. 3050, Australia</aff><aff id="A97"><label>cs</label>Regeneron, Tarrytown, NY 10591, USA</aff><aff id="A98"><label>ct</label>University of Muenster, D-48149 Muenster, Germany</aff><aff id="A99"><label>cu</label>Department of Molecular Biology, University of Salzburg, A-5020 Salzburg, Austria</aff><aff id="A100"><label>cv</label>XanTec Bioanalytics, D-48149 Muenster, Germany</aff><aff id="A101"><label>cw</label>Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA</aff><aff id="A102"><label>cx</label>Lumera, Bothell, WA 98011, USA</aff><aff id="A103"><label>cy</label>Arizona State University, Tempe, AZ 85287, USA</aff><aff id="A104"><label>cz</label>Dyax, Cambridge, MA 02139, USA</aff><aff id="A105"><label>da</label>Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA</aff><aff id="A106"><label>db</label>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA</aff><aff id="A107"><label>dc</label>Zymogenetics, Seattle, WA 98102, USA</aff><aff id="A108"><label>dd</label>Bio-Rad Canada, Edmonton, Alta., Canada T6R 2W6</aff><aff id="A109"><label>de</label>Bio-Rad Canada, Toronto, Ont., Canada</aff><author-notes><corresp id="cor1">Corresponding Author. David G. Myszka. Fax: +1 801 585 3015. <email>dmyszka@cores.utah.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>27</day><month>11</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>3</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>10</month><year>2013</year></pub-date><volume>386</volume><issue>2</issue><fpage>194</fpage><lpage>216</lpage><abstract><p id="P1">To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione <italic>S</italic>-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.</p></abstract><kwd-group><kwd>Biacore</kwd><kwd>Kinetics</kwd><kwd>Optical biosensor</kwd><kwd>Surface plasmon resonance</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>S10 RR027551 || RR</award-id></award-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>P30 CA051008 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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