Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study
Identifieur interne : 001830 ( Pmc/Corpus ); précédent : 001829; suivant : 001831Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study
Auteurs : Helen Kovari ; Caroline A. Sabin ; Bruno Ledergerber ; Lene Ryom ; Signe W. Worm ; Colette Smith ; Andrew Phillips ; Peter Reiss ; Eric Fontas ; Kathy Petoumenos ; Stéphane De Wit ; Philippe Morlat ; Jens D. Lundgren ; Rainer WeberSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2012.
Abstract
In a large prospective multicohort study 22 910 human immunodeficiency virus–positive participants without hepatitis B or C virus coinfection were followed for 114 478 patient-years. The incidence of liver-related death was low at 0.10 per 1000 patient-years. Liverrelated mortality due to antiretroviral drug-related toxicity was rare.
Url:
DOI: 10.1093/cid/cis919
PubMed: 23090925
PubMed Central: 3582358
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Sabin</name><affiliation><nlm:aff id="af2"><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Ledergerber, Bruno" sort="Ledergerber, Bruno" uniqKey="Ledergerber B" first="Bruno" last="Ledergerber">Bruno Ledergerber</name><affiliation><nlm:aff id="af1"><addr-line>Division of Infectious Diseases and Hospital Epidemiology</addr-line>,<institution>University Hospital Zurich, University of Zurich,</institution><country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name><affiliation><nlm:aff id="af3"><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name><affiliation><nlm:aff id="af3"><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name><affiliation><nlm:aff id="af2"><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name><affiliation><nlm:aff id="af2"><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation><nlm:aff id="af4"><addr-line>HIV Monitoring Foundation</addr-line>,<institution>Academic Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation><nlm:aff id="af5"><addr-line>Département de Santé Publique</addr-line>,<institution>Centre Hospitalier Universitaire</institution>,<addr-line>Nice</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Petoumenos, Kathy" sort="Petoumenos, Kathy" uniqKey="Petoumenos K" first="Kathy" last="Petoumenos">Kathy Petoumenos</name><affiliation><nlm:aff id="af6"><addr-line>National Centre in HIV Epidemiology and Clinical Research</addr-line>,<institution>University of New South Wales</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stéphane" last="De Wit">Stéphane De Wit</name><affiliation><nlm:aff id="af7"><addr-line>Department of Infectious Diseases</addr-line>,<institution>St Pierre University Hospital</institution>,<addr-line>Brussels, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Morlat, Philippe" sort="Morlat, Philippe" uniqKey="Morlat P" first="Philippe" last="Morlat">Philippe Morlat</name><affiliation><nlm:aff id="af8"><addr-line>Service de Medicine Interne et Maladies Infectieuses</addr-line>,<institution>Hopital Saint-André</institution>,<addr-line>CHU de Bordeaux</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation><nlm:aff id="af3"><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation><nlm:aff id="af1"><addr-line>Division of Infectious Diseases and Hospital Epidemiology</addr-line>,<institution>University Hospital Zurich, University of Zurich,</institution><country>Switzerland</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23090925</idno><idno type="pmc">3582358</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582358</idno><idno type="RBID">PMC:3582358</idno><idno type="doi">10.1093/cid/cis919</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001830</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001830</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study</title><author><name sortKey="Kovari, Helen" sort="Kovari, Helen" uniqKey="Kovari H" first="Helen" last="Kovari">Helen Kovari</name><affiliation><nlm:aff id="af1"><addr-line>Division of Infectious Diseases and Hospital Epidemiology</addr-line>,<institution>University Hospital Zurich, University of Zurich,</institution><country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Sabin, Caroline A" sort="Sabin, Caroline A" uniqKey="Sabin C" first="Caroline A." last="Sabin">Caroline A. Sabin</name><affiliation><nlm:aff id="af2"><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Ledergerber, Bruno" sort="Ledergerber, Bruno" uniqKey="Ledergerber B" first="Bruno" last="Ledergerber">Bruno Ledergerber</name><affiliation><nlm:aff id="af1"><addr-line>Division of Infectious Diseases and Hospital Epidemiology</addr-line>,<institution>University Hospital Zurich, University of Zurich,</institution><country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name><affiliation><nlm:aff id="af3"><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Worm, Signe W" sort="Worm, Signe W" uniqKey="Worm S" first="Signe W." last="Worm">Signe W. Worm</name><affiliation><nlm:aff id="af3"><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name><affiliation><nlm:aff id="af2"><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name><affiliation><nlm:aff id="af2"><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></nlm:aff></affiliation></author><author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name><affiliation><nlm:aff id="af4"><addr-line>HIV Monitoring Foundation</addr-line>,<institution>Academic Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Fontas, Eric" sort="Fontas, Eric" uniqKey="Fontas E" first="Eric" last="Fontas">Eric Fontas</name><affiliation><nlm:aff id="af5"><addr-line>Département de Santé Publique</addr-line>,<institution>Centre Hospitalier Universitaire</institution>,<addr-line>Nice</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Petoumenos, Kathy" sort="Petoumenos, Kathy" uniqKey="Petoumenos K" first="Kathy" last="Petoumenos">Kathy Petoumenos</name><affiliation><nlm:aff id="af6"><addr-line>National Centre in HIV Epidemiology and Clinical Research</addr-line>,<institution>University of New South Wales</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="De Wit, Stephane" sort="De Wit, Stephane" uniqKey="De Wit S" first="Stéphane" last="De Wit">Stéphane De Wit</name><affiliation><nlm:aff id="af7"><addr-line>Department of Infectious Diseases</addr-line>,<institution>St Pierre University Hospital</institution>,<addr-line>Brussels, Belgium</addr-line></nlm:aff></affiliation></author><author><name sortKey="Morlat, Philippe" sort="Morlat, Philippe" uniqKey="Morlat P" first="Philippe" last="Morlat">Philippe Morlat</name><affiliation><nlm:aff id="af8"><addr-line>Service de Medicine Interne et Maladies Infectieuses</addr-line>,<institution>Hopital Saint-André</institution>,<addr-line>CHU de Bordeaux</addr-line>,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D." last="Lundgren">Jens D. Lundgren</name><affiliation><nlm:aff id="af3"><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></nlm:aff></affiliation></author><author><name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name><affiliation><nlm:aff id="af1"><addr-line>Division of Infectious Diseases and Hospital Epidemiology</addr-line>,<institution>University Hospital Zurich, University of Zurich,</institution><country>Switzerland</country></nlm:aff></affiliation></author></analytic><series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In a large prospective multicohort study 22 910 human immunodeficiency virus–positive participants without hepatitis B or C virus coinfection were followed for 114 478 patient-years. The incidence of liver-related death was low at 0.10 per 1000 patient-years. Liverrelated mortality due to antiretroviral drug-related toxicity was rare.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Clin. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">cid</journal-id><journal-id journal-id-type="hwp">cid</journal-id><journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title></journal-title-group><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23090925</article-id><article-id pub-id-type="pmc">3582358</article-id><article-id pub-id-type="doi">10.1093/cid/cis919</article-id><article-id pub-id-type="publisher-id">cis919</article-id><article-categories><subj-group subj-group-type="heading"><subject>HIV/AIDS</subject></subj-group></article-categories><title-group><article-title>Antiretroviral Drug-Related Liver Mortality Among HIV-Positive Persons in the Absence of Hepatitis B or C Virus Coinfection: The Data Collection on Adverse Events of Anti-HIV Drugs Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kovari</surname><given-names>Helen</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sabin</surname><given-names>Caroline A.</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ledergerber</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ryom</surname><given-names>Lene</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Worm</surname><given-names>Signe W.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Smith</surname><given-names>Colette</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Reiss</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Fontas</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Petoumenos</surname><given-names>Kathy</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>De Wit</surname><given-names>Stéphane</given-names></name><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Morlat</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Lundgren</surname><given-names>Jens D.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Rainer</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Division of Infectious Diseases and Hospital Epidemiology</addr-line>,<institution>University Hospital Zurich, University of Zurich,</institution><country>Switzerland</country></aff><aff id="af2"><label>2</label><addr-line>Research Department of Infection and Population Health, Division of Population Health</addr-line>,<institution>Royal Free and University College</institution>,<addr-line>London</addr-line>,<country>United Kingdom</country></aff><aff id="af3"><label>3</label><addr-line>Copenhagen HIV Programme</addr-line>,<institution>University of Copenhagen</institution>,<country>Denmark</country></aff><aff id="af4"><label>4</label><addr-line>HIV Monitoring Foundation</addr-line>,<institution>Academic Medical Center</institution>,<addr-line>Amsterdam</addr-line>,<country>The Netherlands</country></aff><aff id="af5"><label>5</label><addr-line>Département de Santé Publique</addr-line>,<institution>Centre Hospitalier Universitaire</institution>,<addr-line>Nice</addr-line>,<country>France</country></aff><aff id="af6"><label>6</label><addr-line>National Centre in HIV Epidemiology and Clinical Research</addr-line>,<institution>University of New South Wales</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></aff><aff id="af7"><label>7</label><addr-line>Department of Infectious Diseases</addr-line>,<institution>St Pierre University Hospital</institution>,<addr-line>Brussels, Belgium</addr-line></aff><aff id="af8"><label>8</label><addr-line>Service de Medicine Interne et Maladies Infectieuses</addr-line>,<institution>Hopital Saint-André</institution>,<addr-line>CHU de Bordeaux</addr-line>,<country>France</country></aff><author-notes><corresp>Correspondence: Helen Kovari, MD, Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, CH-8091 Zurich, Switzerland (<email>helen.kovari@usz.ch</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>3</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>10</month><year>2012</year></pub-date><volume>56</volume><issue>6</issue><fpage>870</fpage><lpage>879</lpage><history><date date-type="received"><day>11</day><month>7</month><year>2012</year></date><date date-type="accepted"><day>11</day><month>10</month><year>2012</year></date></history><permissions><copyright-statement>© The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>.</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="cis919.pdf"></self-uri><abstract abstract-type="precis"><p>In a large prospective multicohort study 22 910 human immunodeficiency virus–positive participants without hepatitis B or C virus coinfection were followed for 114 478 patient-years. The incidence of liver-related death was low at 0.10 per 1000 patient-years. Liverrelated mortality due to antiretroviral drug-related toxicity was rare.</p></abstract><abstract><p><bold><italic>Background.</italic></bold> Liver diseases are the leading causes of death in human immunodeficiency virus (HIV)–positive persons since the widespread use of combination antiretroviral treatment (cART). Most of these deaths are due to hepatitis C (HCV) or B (HBV) virus coinfections. Little is known about other causes. Prolonged exposure to some antiretroviral drugs might increase hepatic mortality.</p><p><bold><italic>Methods.</italic></bold> All patients in the Data Collection on Adverse Events of Anti-HIV Drugs study without HCV or HBV coinfection were prospectively followed from date of entry until death or last follow-up. In patients with liver-related death, clinical charts were reviewed using a structured questionnaire.</p><p><bold><italic>Results.</italic></bold> We followed 22 910 participants without hepatitis virus coinfection for 114 478 person-years. There were 12 liver-related deaths (incidence, 0.10/1000 person-years); 7 due to severe alcohol use and 5 due to established ART-related toxicity. The rate of ART-related deaths in treatment-experienced persons was 0.04/1000 person-years (95% confidence interval, .01, .10).</p><p><bold><italic>Conclusions.</italic></bold> We found a low incidence of liver-related deaths in HIV-infected persons without HCV or HBV coinfection. Liver-related mortality because of ART-related toxicity was rare.</p></abstract><kwd-group><kwd>liver-related mortality</kwd><kwd>drug toxicity</kwd><kwd>antiretroviral therapy</kwd><kwd>HIV infection</kwd><kwd>cohort study</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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