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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise</title><author><name sortKey="Renoir, Thibault" sort="Renoir, Thibault" uniqKey="Renoir T" first="Thibault" last="Renoir">Thibault Renoir</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pang, Terence Yc" sort="Pang, Terence Yc" uniqKey="Pang T" first="Terence Yc" last="Pang">Terence Yc Pang</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zajac, Michelle S" sort="Zajac, Michelle S" uniqKey="Zajac M" first="Michelle S" last="Zajac">Michelle S. Zajac</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Grace" sort="Chan, Grace" uniqKey="Chan G" first="Grace" last="Chan">Grace Chan</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Du, Xin" sort="Du, Xin" uniqKey="Du X" first="Xin" last="Du">Xin Du</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leang, Leah" sort="Leang, Leah" uniqKey="Leang L" first="Leah" last="Leang">Leah Leang</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chevarin, Caroline" sort="Chevarin, Caroline" uniqKey="Chevarin C" first="Caroline" last="Chevarin">Caroline Chevarin</name><affiliation><nlm:aff id="au3"><institution>Inserm, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>UPMC, Univ Paris 06, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lanfumey, Laurence" sort="Lanfumey, Laurence" uniqKey="Lanfumey L" first="Laurence" last="Lanfumey">Laurence Lanfumey</name><affiliation><nlm:aff id="au3"><institution>Inserm, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>UPMC, Univ Paris 06, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hannan, Anthony J" sort="Hannan, Anthony J" uniqKey="Hannan A" first="Anthony J" last="Hannan">Anthony J. Hannan</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21718306</idno><idno type="pmc">3372723</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372723</idno><idno type="RBID">PMC:3372723</idno><idno type="doi">10.1111/j.1476-5381.2011.01567.x</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001813</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001813</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise</title><author><name sortKey="Renoir, Thibault" sort="Renoir, Thibault" uniqKey="Renoir T" first="Thibault" last="Renoir">Thibault Renoir</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Pang, Terence Yc" sort="Pang, Terence Yc" uniqKey="Pang T" first="Terence Yc" last="Pang">Terence Yc Pang</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zajac, Michelle S" sort="Zajac, Michelle S" uniqKey="Zajac M" first="Michelle S" last="Zajac">Michelle S. Zajac</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chan, Grace" sort="Chan, Grace" uniqKey="Chan G" first="Grace" last="Chan">Grace Chan</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Du, Xin" sort="Du, Xin" uniqKey="Du X" first="Xin" last="Du">Xin Du</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Leang, Leah" sort="Leang, Leah" uniqKey="Leang L" first="Leah" last="Leang">Leah Leang</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chevarin, Caroline" sort="Chevarin, Caroline" uniqKey="Chevarin C" first="Caroline" last="Chevarin">Caroline Chevarin</name><affiliation><nlm:aff id="au3"><institution>Inserm, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>UPMC, Univ Paris 06, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lanfumey, Laurence" sort="Lanfumey, Laurence" uniqKey="Lanfumey L" first="Laurence" last="Lanfumey">Laurence Lanfumey</name><affiliation><nlm:aff id="au3"><institution>Inserm, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au4"><institution>UPMC, Univ Paris 06, UMR S894</institution><addr-line>Paris, France</addr-line></nlm:aff></affiliation></author><author><name sortKey="Hannan, Anthony J" sort="Hannan, Anthony J" uniqKey="Hannan A" first="Anthony J" last="Hannan">Anthony J. Hannan</name><affiliation><nlm:aff id="au1"><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="au2"><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Pharmacology</title><idno type="ISSN">0007-1188</idno><idno type="eISSN">1476-5381</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND AND PURPOSE</title><p>Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation.</p></sec><sec><title>EXPERIMENTAL APPROACH</title><p>We performed tests of depression-related behaviours on female R6/1 HD mice that had been chronically treated with sertraline or provided with running-wheels. Functional assessments of 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors were performed by measuring behavioural and physiological responses following administration of specific agonists, in combination with analysis of hippocampal gene expression. Finally we assessed the effect of exercise on hippocampal cell proliferation.</p></sec><sec><title>KEY RESULTS</title><p>Female HD mice recorded increased immobility time in the forced-swimming test, reduced saccharin preference and a hyperthermic response to stress compared with wild-type animals. These alterations were improved by chronic sertraline treatment. Wheel-running also resulted in similar improvements with the exception of saccharin preference but failed to correct the hippocampal cell proliferation deficits displayed by HD mice. The benefits of sertraline treatment and exercise involved altered 5-HT<sub>1A</sub> autoreceptor function, as demonstrated by modulation of the exaggerated 8-OH-DPAT-induced hypothermia exhibited by female HD mice. On the other hand, sertraline treatment was unable to restore the reduced 5-HT<sub>1A</sub> and 5-HT<sub>2</sub> heteroceptor function observed in HD animals.</p></sec><sec><title>CONCLUSIONS AND IMPLICATIONS</title><p>We report for the first time a crucial role for 5-HT<sub>1A</sub> autoreceptor function in mediating the sex-specific depressive-like phenotype of female R6/1 HD mice. Our data further support a differential effect of chronic sertraline treatment and exercise on hippocampal cell proliferation despite common behavioural benefits.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Pharmacol</journal-id><journal-id journal-id-type="iso-abbrev">Br. J. Pharmacol</journal-id><journal-id journal-id-type="publisher-id">bph</journal-id><journal-title-group><journal-title>British Journal of Pharmacology</journal-title></journal-title-group><issn pub-type="ppub">0007-1188</issn><issn pub-type="epub">1476-5381</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21718306</article-id><article-id pub-id-type="pmc">3372723</article-id><article-id pub-id-type="doi">10.1111/j.1476-5381.2011.01567.x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Papers</subject></subj-group></article-categories><title-group><article-title>Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Renoir</surname><given-names>Thibault</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pang</surname><given-names>Terence YC</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zajac</surname><given-names>Michelle S</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Grace</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Du</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><contrib contrib-type="author"><name><surname>Leang</surname><given-names>Leah</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chevarin</surname><given-names>Caroline</given-names></name><xref ref-type="aff" rid="au3">3</xref><xref ref-type="aff" rid="au4">4</xref></contrib><contrib contrib-type="author"><name><surname>Lanfumey</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="au3">3</xref><xref ref-type="aff" rid="au4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hannan</surname><given-names>Anthony J</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><aff id="au1"><label>1</label><institution>Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Anatomy and Cell Biology, University of Melbourne</institution><addr-line>Parkville, Victoria, Australia</addr-line></aff><aff id="au3"><label>3</label><institution>Inserm, UMR S894</institution><addr-line>Paris, France</addr-line></aff><aff id="au4"><label>4</label><institution>UPMC, Univ Paris 06, UMR S894</institution><addr-line>Paris, France</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Thibault Renoir, Howard Florey Institute, University of Melbourne, Parkville, Vic. 3010, Australia. E-mail: <email>thibault.renoir@florey.edu.au</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2012</year></pub-date><volume>165</volume><issue>5</issue><fpage>1375</fpage><lpage>1389</lpage><history><date date-type="received"><day>02</day><month>11</month><year>2010</year></date><date date-type="rev-recd"><day>07</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>16</day><month>6</month><year>2011</year></date></history><permissions><copyright-statement>© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec><title>BACKGROUND AND PURPOSE</title><p>Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. Women are more prone to develop depression and such susceptibility might be related to 5-hydroxytryptaminergic (serotonergic) dysregulation.</p></sec><sec><title>EXPERIMENTAL APPROACH</title><p>We performed tests of depression-related behaviours on female R6/1 HD mice that had been chronically treated with sertraline or provided with running-wheels. Functional assessments of 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors were performed by measuring behavioural and physiological responses following administration of specific agonists, in combination with analysis of hippocampal gene expression. Finally we assessed the effect of exercise on hippocampal cell proliferation.</p></sec><sec><title>KEY RESULTS</title><p>Female HD mice recorded increased immobility time in the forced-swimming test, reduced saccharin preference and a hyperthermic response to stress compared with wild-type animals. These alterations were improved by chronic sertraline treatment. Wheel-running also resulted in similar improvements with the exception of saccharin preference but failed to correct the hippocampal cell proliferation deficits displayed by HD mice. The benefits of sertraline treatment and exercise involved altered 5-HT<sub>1A</sub> autoreceptor function, as demonstrated by modulation of the exaggerated 8-OH-DPAT-induced hypothermia exhibited by female HD mice. On the other hand, sertraline treatment was unable to restore the reduced 5-HT<sub>1A</sub> and 5-HT<sub>2</sub> heteroceptor function observed in HD animals.</p></sec><sec><title>CONCLUSIONS AND IMPLICATIONS</title><p>We report for the first time a crucial role for 5-HT<sub>1A</sub> autoreceptor function in mediating the sex-specific depressive-like phenotype of female R6/1 HD mice. Our data further support a differential effect of chronic sertraline treatment and exercise on hippocampal cell proliferation despite common behavioural benefits.</p></sec></abstract><kwd-group><kwd>depression</kwd><kwd>Huntington's disease</kwd><kwd>exercise</kwd><kwd>5-HT</kwd><kwd>serotonin</kwd><kwd>behaviour</kwd><kwd>neurogenesis</kwd><kwd>sertraline</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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