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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Consensus guidelines for the detection of immunogenic cell death</title><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Senovilla, Laura" sort="Senovilla, Laura" uniqKey="Senovilla L" first="Laura" last="Senovilla">Laura Senovilla</name><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0004"><institution>INSERM; U1015</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name><affiliation><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Vacchelli, Erika" sort="Vacchelli, Erika" uniqKey="Vacchelli E" first="Erika" last="Vacchelli">Erika Vacchelli</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0007"><institution>Molecular Cell Biology Laboratory; Department of Immunology; Institute of Biomedical Sciences; University of São Paulo</institution>; São Paulo,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Agostinis, Patrizia" sort="Agostinis, Patrizia" uniqKey="Agostinis P" first="Patrizia" last="Agostinis">Patrizia Agostinis</name><affiliation><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>; Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Apetoh, Lionel" sort="Apetoh, Lionel" uniqKey="Apetoh L" first="Lionel" last="Apetoh">Lionel Apetoh</name><affiliation><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>; Dijon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Aranda, Fernando" sort="Aranda, Fernando" uniqKey="Aranda F" first="Fernando" last="Aranda">Fernando Aranda</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Barnaba, Vincenzo" sort="Barnaba, Vincenzo" uniqKey="Barnaba V" first="Vincenzo" last="Barnaba">Vincenzo Barnaba</name><affiliation><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bloy, Norma" sort="Bloy, Norma" uniqKey="Bloy N" first="Norma" last="Bloy">Norma Bloy</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bracci, Laura" sort="Bracci, Laura" uniqKey="Bracci L" first="Laura" last="Bracci">Laura Bracci</name><affiliation><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Breckpot, Karine" sort="Breckpot, Karine" uniqKey="Breckpot K" first="Karine" last="Breckpot">Karine Breckpot</name><affiliation><nlm:aff id="af0015"><institution>Laboratory of Molecular and Cellular Therapy (LMCT); Department of Biomedical Sciences Medical School of the Free University of Brussels (VUB)</institution>; Jette,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Brough, David" sort="Brough, David" uniqKey="Brough D" first="David" last="Brough">David Brough</name><affiliation><nlm:aff id="af0016"><institution>Faculty of Life Sciences; University of Manchester</institution>; Manchester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Buque, Aitziber" sort="Buque, Aitziber" uniqKey="Buque A" first="Aitziber" last="Buqué">Aitziber Buqué</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Castro, Maria G" sort="Castro, Maria G" uniqKey="Castro M" first="Maria G." last="Castro">Maria G. Castro</name><affiliation><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>; Ann Arbor, MI<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name><affiliation><nlm:aff id="af0018"><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Colombo, Maria I" sort="Colombo, Maria I" uniqKey="Colombo M" first="Maria I." last="Colombo">Maria I. Colombo</name><affiliation><nlm:aff id="af0019"><institution>Laboratorio de Biología Celular y Molecular; Instituto de Histología y Embriología (IHEM); Facultad de Ciencias Médicas; Universidad Nacional de Cuyo; CONICET</institution>; Mendoza,<country>Argentina</country></nlm:aff></affiliation></author><author><name sortKey="Cremer, Isabelle" sort="Cremer, Isabelle" uniqKey="Cremer I" first="Isabelle" last="Cremer">Isabelle Cremer</name><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0021"><institution>Equipe 13; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name><affiliation><nlm:aff id="af0022"><institution>Department of Pathology; New York University School of Medicine</institution>; New York, NY<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Dini, Luciana" sort="Dini, Luciana" uniqKey="Dini L" first="Luciana" last="Dini">Luciana Dini</name><affiliation><nlm:aff id="af0023"><institution>Department of Biological and Environmental Science and Technology (DiSTeBA); University of Salento</institution>; Lecce,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Eliopoulos, Aristides G" sort="Eliopoulos, Aristides G" uniqKey="Eliopoulos A" first="Aristides G." last="Eliopoulos">Aristides G. Eliopoulos</name><affiliation><nlm:aff id="af0024"><institution>Molecular and Cellular Biology Laboratory; Division of Basic Sciences; University of Crete Medical School</institution>; Heraklion,<country>Greece</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0025"><institution>Institute of Molecular Biology and Biotechnology; Foundation of Research and Technology - Hellas</institution>; Heraklion,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Faggioni, Alberto" sort="Faggioni, Alberto" uniqKey="Faggioni A" first="Alberto" last="Faggioni">Alberto Faggioni</name><affiliation><nlm:aff id="af0018"><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Formenti, Silvia C" sort="Formenti, Silvia C" uniqKey="Formenti S" first="Silvia C." last="Formenti">Silvia C. Formenti</name><affiliation><nlm:aff id="af0026"><institution>Department of Radiation Oncology; NewYork University School of Medicine and Langone Medical Center</institution>; New York, NY<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Fu Kova, Jitka" sort="Fu Kova, Jitka" uniqKey="Fu Kova J" first="Jitka" last="Fu Ková">Jitka Fu Ková</name><affiliation><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup> Faculty of Medicine and University Hospital Motol, Charles University</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0028"><institution>Sotio</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Gabriele, Lucia" sort="Gabriele, Lucia" uniqKey="Gabriele L" first="Lucia" last="Gabriele">Lucia Gabriele</name><affiliation><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Gaipl, Udo S" sort="Gaipl, Udo S" uniqKey="Gaipl U" first="Udo S." last="Gaipl">Udo S. Gaipl</name><affiliation><nlm:aff id="af0029"><institution>Department of Radiation Oncology; University Hospital Erlangen; University of Erlangen-Nürnberg</institution>; Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0031"><institution>Laboratory of Integrative Cancer Immunology; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Garg, Abhishek" sort="Garg, Abhishek" uniqKey="Garg A" first="Abhishek" last="Garg">Abhishek Garg</name><affiliation><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>; Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name><affiliation><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>; Dijon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A." last="Giese">Nathalia A. Giese</name><affiliation><nlm:aff id="af0032"><institution>European Pancreas Center; Department of Surgery; University Hospital Heidelberg</institution>; Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name><affiliation><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hemminki, Akseli" sort="Hemminki, Akseli" uniqKey="Hemminki A" first="Akseli" last="Hemminki">Akseli Hemminki</name><affiliation><nlm:aff id="af0034"><institution>Cancer Gene Therapy Group; Transplantation laboratory; Haartman Institute; University of Helsinki</institution>; Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name><affiliation><nlm:aff id="af0035"><institution>Department of Internal Medicine 3; University of Erlangen-Nuremberg</institution>; Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hodge, James W" sort="Hodge, James W" uniqKey="Hodge J" first="James W." last="Hodge">James W. Hodge</name><affiliation><nlm:aff id="af0036"><institution>Laboratory of Tumor Immunology and Biology; Center for Cancer Research; National Cancer Institute (NCI), National Institutes of Health (NIH)</institution>; Bethesda, MD<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Holdenrieder, Stefan" sort="Holdenrieder, Stefan" uniqKey="Holdenrieder S" first="Stefan" last="Holdenrieder">Stefan Holdenrieder</name><affiliation><nlm:aff id="af0037"><institution>Institute of Clinical Chemistry and Clinical Pharmacology; University Hospital Bonn</institution>; Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Honeychurch, Jamie" sort="Honeychurch, Jamie" uniqKey="Honeychurch J" first="Jamie" last="Honeychurch">Jamie Honeychurch</name><affiliation><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>; Manchester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hu, Hong Min" sort="Hu, Hong Min" uniqKey="Hu H" first="Hong-Min" last="Hu">Hong-Min Hu</name><affiliation><nlm:aff id="af0039"><institution>Cancer Research and Biotherapy Center; Second Affiliated Hospital of Southeast University</institution>; Nanjing,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0040"><institution>Laboratory of Cancer Immunobiology; Earle A. Chiles Research Institute; Providence Portland Medical Center</institution>; Portland, OR<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Huang, Xing" sort="Huang, Xing" uniqKey="Huang X" first="Xing" last="Huang">Xing Huang</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Illidge, Tim M" sort="Illidge, Tim M" uniqKey="Illidge T" first="Tim M." last="Illidge">Tim M. Illidge</name><affiliation><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>; Manchester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kono, Koji" sort="Kono, Koji" uniqKey="Kono K" first="Koji" last="Kono">Koji Kono</name><affiliation><nlm:aff id="af0041"><institution>Department of Surgery; National University of Singapore</institution>; Singapore,<country>Singapore</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0042"><institution>Cancer Science Institute of Singapore; National University of Singapore</institution>; Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Korbelik, Mladen" sort="Korbelik, Mladen" uniqKey="Korbelik M" first="Mladen" last="Korbelik">Mladen Korbelik</name><affiliation><nlm:aff id="af0043"><institution>British Columbia Cancer Agency</institution>; Vancouver,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Krysko, Dmitri V" sort="Krysko, Dmitri V" uniqKey="Krysko D" first="Dmitri V." last="Krysko">Dmitri V. Krysko</name><affiliation><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><affiliation><nlm:aff id="af0046"><institution>Division of Cancer Medicine and Division of Research; Peter MacCallum Cancer Center; East Melbourne</institution>; Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Lowenstein, Pedro R" sort="Lowenstein, Pedro R" uniqKey="Lowenstein P" first="Pedro R." last="Lowenstein">Pedro R. Lowenstein</name><affiliation><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>; Ann Arbor, MI<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lugli, Enrico" sort="Lugli, Enrico" uniqKey="Lugli E" first="Enrico" last="Lugli">Enrico Lugli</name><affiliation><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>; Milan,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>; Rozzano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation><nlm:aff id="af0049"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff></affiliation></author><author><name sortKey="Manfredi, Angelo A" sort="Manfredi, Angelo A" uniqKey="Manfredi A" first="Angelo A." last="Manfredi">Angelo A. Manfredi</name><affiliation><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>; Milano,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>; Milano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Martins, Isabelle" sort="Martins, Isabelle" uniqKey="Martins I" first="Isabelle" last="Martins">Isabelle Martins</name><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0052"><institution>INSERM, U1030</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0053"><institution>Faculté de Médecine; Université Paris-Sud/Paris XI</institution>; Kremlin-Bicêtre,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mavilio, Domenico" sort="Mavilio, Domenico" uniqKey="Mavilio D" first="Domenico" last="Mavilio">Domenico Mavilio</name><affiliation><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>; Milan,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>; Rozzano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Menger, Laurie" sort="Menger, Laurie" uniqKey="Menger L" first="Laurie" last="Menger">Laurie Menger</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0054"><institution>Cancer Immunology Unit, Research Department of Haematology; University College London (UCL) Cancer Institute</institution>; London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Merendino, Nicol" sort="Merendino, Nicol" uniqKey="Merendino N" first="Nicol" last="Merendino">Nicol Merendino</name><affiliation><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>; Viterbo,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Michaud, Michael" sort="Michaud, Michael" uniqKey="Michaud M" first="Michael" last="Michaud">Michael Michaud</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mignot, Gregoire" sort="Mignot, Gregoire" uniqKey="Mignot G" first="Gregoire" last="Mignot">Gregoire Mignot</name><affiliation><nlm:aff id="af0056"><institution>Cellular and Molecular Immunology and Endocrinology</institution>, Oniris; Nantes,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mossman, Karen L" sort="Mossman, Karen L" uniqKey="Mossman K" first="Karen L." last="Mossman">Karen L. Mossman</name><affiliation><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Multhoff, Gabriele" sort="Multhoff, Gabriele" uniqKey="Multhoff G" first="Gabriele" last="Multhoff">Gabriele Multhoff</name><affiliation><nlm:aff id="af0059"><institution>Department of Radiation Oncology; Klinikum rechts der Isar; Technical University of Munich</institution>; Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Oehler, Rudolf" sort="Oehler, Rudolf" uniqKey="Oehler R" first="Rudolf" last="Oehler">Rudolf Oehler</name><affiliation><nlm:aff id="af0060"><institution>Comprehensive Cancer Center; Medical University of Vienna</institution>; Vienna,<country>Austria</country></nlm:aff></affiliation></author><author><name sortKey="Palombo, Fabio" sort="Palombo, Fabio" uniqKey="Palombo F" first="Fabio" last="Palombo">Fabio Palombo</name><affiliation><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Panaretakis, Theocharis" sort="Panaretakis, Theocharis" uniqKey="Panaretakis T" first="Theocharis" last="Panaretakis">Theocharis Panaretakis</name><affiliation><nlm:aff id="af0061"><institution>Department of Oncology-Pathology; Karolinska Institute</institution>; Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Pol, Jonathan" sort="Pol, Jonathan" uniqKey="Pol J" first="Jonathan" last="Pol">Jonathan Pol</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name><affiliation><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ricci, Jean Ehrland" sort="Ricci, Jean Ehrland" uniqKey="Ricci J" first="Jean-Ehrland" last="Ricci">Jean-Ehrland Ricci</name><affiliation><nlm:aff id="af0062"><institution>INSERM; U1065</institution>; Nice,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0063"><institution>Equipe “Contrôle Métabolique des Morts Cellulaires,” Center Méditerranéen de Médecine Moléculaire (C3M)</institution>; Nice,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0064"><institution>Faculté de Médecine; Université de Nice Sophia Antipolis</institution>; Nice,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0065"><institution>Centre Hospitalier Universitaire de Nice</institution>; Nice,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name><affiliation><nlm:aff id="af0066"><institution>Department of Oncology and Subalpine Center for Research and Experimental Medicine (CeRMS); University of Turin</institution>; Turin,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name><affiliation><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>; Milano,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>; Milano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Rubartelli, Anna" sort="Rubartelli, Anna" uniqKey="Rubartelli A" first="Anna" last="Rubartelli">Anna Rubartelli</name><affiliation><nlm:aff id="af0067"><institution>Cell Biology Unit; Azienda Ospedaliera Universitaria San Martino</institution>;<institution>Istituto Nazionale per la Ricerca sul Cancro</institution>; Genova,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name><affiliation><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name><affiliation><nlm:aff id="af0068"><institution>Immunology in Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute</institution>; Herston,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0069"><institution>School of Medicine, University of Queensland</institution>; Herston,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Sonnemann, Juergen" sort="Sonnemann, Juergen" uniqKey="Sonnemann J" first="Juergen" last="Sonnemann">Juergen Sonnemann</name><affiliation><nlm:aff id="af0070"><institution>Department of Pediatric Haematology and Oncology; Jena University Hospital, Children's Clinic</institution>; Jena,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Spisek, Radek" sort="Spisek, Radek" uniqKey="Spisek R" first="Radek" last="Spisek">Radek Spisek</name><affiliation><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup> Faculty of Medicine and University Hospital Motol, Charles University</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0028"><institution>Sotio</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Stagg, John" sort="Stagg, John" uniqKey="Stagg J" first="John" last="Stagg">John Stagg</name><affiliation><nlm:aff id="af0071"><institution>Centre de Recherche du Center Hospitalier de l’Université de Montréal; Faculté de Pharmacie, Université de Montréal</institution>; Montréal,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Sukkurwala, Abdul Qader" sort="Sukkurwala, Abdul Qader" uniqKey="Sukkurwala A" first="Abdul Qader" last="Sukkurwala">Abdul Qader Sukkurwala</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0072"><institution>Department of Pathology, Dow International Medical College; Dow University of Health Sciences</institution>; Karachi,<country>Pakistan</country></nlm:aff></affiliation></author><author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name><affiliation><nlm:aff id="af0073"><institution>INSERM; U970</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Thorburn, Andrew" sort="Thorburn, Andrew" uniqKey="Thorburn A" first="Andrew" last="Thorburn">Andrew Thorburn</name><affiliation><nlm:aff id="af0075"><institution>Department of Pharmacology; University of Colorado School of Medicine</institution>; Aurora, CO<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Thorne, Stephen H" sort="Thorne, Stephen H" uniqKey="Thorne S" first="Stephen H." last="Thorne">Stephen H. Thorne</name><affiliation><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Vandenabeele, Peter" sort="Vandenabeele, Peter" uniqKey="Vandenabeele P" first="Peter" last="Vandenabeele">Peter Vandenabeele</name><affiliation><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0076"><institution>Methusalem Program; Ghent University</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Velotti, Francesca" sort="Velotti, Francesca" uniqKey="Velotti F" first="Francesca" last="Velotti">Francesca Velotti</name><affiliation><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>; Viterbo,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Workenhe, Samuel T" sort="Workenhe, Samuel T" uniqKey="Workenhe S" first="Samuel T." last="Workenhe">Samuel T. Workenhe</name><affiliation><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Yang, Haining" sort="Yang, Haining" uniqKey="Yang H" first="Haining" last="Yang">Haining Yang</name><affiliation><nlm:aff id="af0077"><institution>University of Hawaii Cancer Center</institution>; Honolulu, HI<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Zong, Wei Xing" sort="Zong, Wei Xing" uniqKey="Zong W" first="Wei-Xing" last="Zong">Wei-Xing Zong</name><affiliation><nlm:aff id="af0078"><institution>Department of Molecular Genetics and Microbiology; Stony Brook University</institution>; Stony Brook, NY<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation><nlm:aff id="af0004"><institution>INSERM; U1015</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0079"><institution>Centre d’Investigation Clinique Biothérapie 507 (CICBT507); Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25941621</idno><idno type="pmc">4292729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292729</idno><idno type="RBID">PMC:4292729</idno><idno type="doi">10.4161/21624011.2014.955691</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000395</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000395</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Consensus guidelines for the detection of immunogenic cell death</title><author><name sortKey="Kepp, Oliver" sort="Kepp, Oliver" uniqKey="Kepp O" first="Oliver" last="Kepp">Oliver Kepp</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Senovilla, Laura" sort="Senovilla, Laura" uniqKey="Senovilla L" first="Laura" last="Senovilla">Laura Senovilla</name><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0004"><institution>INSERM; U1015</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Vitale, Ilio" sort="Vitale, Ilio" uniqKey="Vitale I" first="Ilio" last="Vitale">Ilio Vitale</name><affiliation><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Vacchelli, Erika" sort="Vacchelli, Erika" uniqKey="Vacchelli E" first="Erika" last="Vacchelli">Erika Vacchelli</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Adjemian, Sandy" sort="Adjemian, Sandy" uniqKey="Adjemian S" first="Sandy" last="Adjemian">Sandy Adjemian</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0007"><institution>Molecular Cell Biology Laboratory; Department of Immunology; Institute of Biomedical Sciences; University of São Paulo</institution>; São Paulo,<country>Brazil</country></nlm:aff></affiliation></author><author><name sortKey="Agostinis, Patrizia" sort="Agostinis, Patrizia" uniqKey="Agostinis P" first="Patrizia" last="Agostinis">Patrizia Agostinis</name><affiliation><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>; Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Apetoh, Lionel" sort="Apetoh, Lionel" uniqKey="Apetoh L" first="Lionel" last="Apetoh">Lionel Apetoh</name><affiliation><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>; Dijon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Aranda, Fernando" sort="Aranda, Fernando" uniqKey="Aranda F" first="Fernando" last="Aranda">Fernando Aranda</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Barnaba, Vincenzo" sort="Barnaba, Vincenzo" uniqKey="Barnaba V" first="Vincenzo" last="Barnaba">Vincenzo Barnaba</name><affiliation><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Bloy, Norma" sort="Bloy, Norma" uniqKey="Bloy N" first="Norma" last="Bloy">Norma Bloy</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bracci, Laura" sort="Bracci, Laura" uniqKey="Bracci L" first="Laura" last="Bracci">Laura Bracci</name><affiliation><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Breckpot, Karine" sort="Breckpot, Karine" uniqKey="Breckpot K" first="Karine" last="Breckpot">Karine Breckpot</name><affiliation><nlm:aff id="af0015"><institution>Laboratory of Molecular and Cellular Therapy (LMCT); Department of Biomedical Sciences Medical School of the Free University of Brussels (VUB)</institution>; Jette,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Brough, David" sort="Brough, David" uniqKey="Brough D" first="David" last="Brough">David Brough</name><affiliation><nlm:aff id="af0016"><institution>Faculty of Life Sciences; University of Manchester</institution>; Manchester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Buque, Aitziber" sort="Buque, Aitziber" uniqKey="Buque A" first="Aitziber" last="Buqué">Aitziber Buqué</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Castro, Maria G" sort="Castro, Maria G" uniqKey="Castro M" first="Maria G." last="Castro">Maria G. Castro</name><affiliation><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>; Ann Arbor, MI<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name><affiliation><nlm:aff id="af0018"><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Colombo, Maria I" sort="Colombo, Maria I" uniqKey="Colombo M" first="Maria I." last="Colombo">Maria I. Colombo</name><affiliation><nlm:aff id="af0019"><institution>Laboratorio de Biología Celular y Molecular; Instituto de Histología y Embriología (IHEM); Facultad de Ciencias Médicas; Universidad Nacional de Cuyo; CONICET</institution>; Mendoza,<country>Argentina</country></nlm:aff></affiliation></author><author><name sortKey="Cremer, Isabelle" sort="Cremer, Isabelle" uniqKey="Cremer I" first="Isabelle" last="Cremer">Isabelle Cremer</name><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0021"><institution>Equipe 13; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name><affiliation><nlm:aff id="af0022"><institution>Department of Pathology; New York University School of Medicine</institution>; New York, NY<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Dini, Luciana" sort="Dini, Luciana" uniqKey="Dini L" first="Luciana" last="Dini">Luciana Dini</name><affiliation><nlm:aff id="af0023"><institution>Department of Biological and Environmental Science and Technology (DiSTeBA); University of Salento</institution>; Lecce,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Eliopoulos, Aristides G" sort="Eliopoulos, Aristides G" uniqKey="Eliopoulos A" first="Aristides G." last="Eliopoulos">Aristides G. Eliopoulos</name><affiliation><nlm:aff id="af0024"><institution>Molecular and Cellular Biology Laboratory; Division of Basic Sciences; University of Crete Medical School</institution>; Heraklion,<country>Greece</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0025"><institution>Institute of Molecular Biology and Biotechnology; Foundation of Research and Technology - Hellas</institution>; Heraklion,<country>Greece</country></nlm:aff></affiliation></author><author><name sortKey="Faggioni, Alberto" sort="Faggioni, Alberto" uniqKey="Faggioni A" first="Alberto" last="Faggioni">Alberto Faggioni</name><affiliation><nlm:aff id="af0018"><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Formenti, Silvia C" sort="Formenti, Silvia C" uniqKey="Formenti S" first="Silvia C." last="Formenti">Silvia C. Formenti</name><affiliation><nlm:aff id="af0026"><institution>Department of Radiation Oncology; NewYork University School of Medicine and Langone Medical Center</institution>; New York, NY<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Fu Kova, Jitka" sort="Fu Kova, Jitka" uniqKey="Fu Kova J" first="Jitka" last="Fu Ková">Jitka Fu Ková</name><affiliation><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup> Faculty of Medicine and University Hospital Motol, Charles University</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0028"><institution>Sotio</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Gabriele, Lucia" sort="Gabriele, Lucia" uniqKey="Gabriele L" first="Lucia" last="Gabriele">Lucia Gabriele</name><affiliation><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Gaipl, Udo S" sort="Gaipl, Udo S" uniqKey="Gaipl U" first="Udo S." last="Gaipl">Udo S. Gaipl</name><affiliation><nlm:aff id="af0029"><institution>Department of Radiation Oncology; University Hospital Erlangen; University of Erlangen-Nürnberg</institution>; Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0020"><institution>Université Pierre et Marie Curie/Paris VI</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0031"><institution>Laboratory of Integrative Cancer Immunology; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Garg, Abhishek" sort="Garg, Abhishek" uniqKey="Garg A" first="Abhishek" last="Garg">Abhishek Garg</name><affiliation><nlm:aff id="af0008"><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>; Leuven,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Ghiringhelli, Francois" sort="Ghiringhelli, Francois" uniqKey="Ghiringhelli F" first="François" last="Ghiringhelli">François Ghiringhelli</name><affiliation><nlm:aff id="af0009"><institution>INSERM; UMR866</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0010"><institution>Centre Georges François Leclerc</institution>; Dijon,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0011"><institution>Université de Bourgogne</institution>; Dijon,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Giese, Nathalia A" sort="Giese, Nathalia A" uniqKey="Giese N" first="Nathalia A." last="Giese">Nathalia A. Giese</name><affiliation><nlm:aff id="af0032"><institution>European Pancreas Center; Department of Surgery; University Hospital Heidelberg</institution>; Heidelberg,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Guo, Zong Sheng" sort="Guo, Zong Sheng" uniqKey="Guo Z" first="Zong Sheng" last="Guo">Zong Sheng Guo</name><affiliation><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Hemminki, Akseli" sort="Hemminki, Akseli" uniqKey="Hemminki A" first="Akseli" last="Hemminki">Akseli Hemminki</name><affiliation><nlm:aff id="af0034"><institution>Cancer Gene Therapy Group; Transplantation laboratory; Haartman Institute; University of Helsinki</institution>; Helsinki,<country>Finland</country></nlm:aff></affiliation></author><author><name sortKey="Herrmann, Martin" sort="Herrmann, Martin" uniqKey="Herrmann M" first="Martin" last="Herrmann">Martin Herrmann</name><affiliation><nlm:aff id="af0035"><institution>Department of Internal Medicine 3; University of Erlangen-Nuremberg</institution>; Erlangen,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Hodge, James W" sort="Hodge, James W" uniqKey="Hodge J" first="James W." last="Hodge">James W. Hodge</name><affiliation><nlm:aff id="af0036"><institution>Laboratory of Tumor Immunology and Biology; Center for Cancer Research; National Cancer Institute (NCI), National Institutes of Health (NIH)</institution>; Bethesda, MD<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Holdenrieder, Stefan" sort="Holdenrieder, Stefan" uniqKey="Holdenrieder S" first="Stefan" last="Holdenrieder">Stefan Holdenrieder</name><affiliation><nlm:aff id="af0037"><institution>Institute of Clinical Chemistry and Clinical Pharmacology; University Hospital Bonn</institution>; Bonn,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Honeychurch, Jamie" sort="Honeychurch, Jamie" uniqKey="Honeychurch J" first="Jamie" last="Honeychurch">Jamie Honeychurch</name><affiliation><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>; Manchester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Hu, Hong Min" sort="Hu, Hong Min" uniqKey="Hu H" first="Hong-Min" last="Hu">Hong-Min Hu</name><affiliation><nlm:aff id="af0039"><institution>Cancer Research and Biotherapy Center; Second Affiliated Hospital of Southeast University</institution>; Nanjing,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0040"><institution>Laboratory of Cancer Immunobiology; Earle A. Chiles Research Institute; Providence Portland Medical Center</institution>; Portland, OR<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Huang, Xing" sort="Huang, Xing" uniqKey="Huang X" first="Xing" last="Huang">Xing Huang</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Illidge, Tim M" sort="Illidge, Tim M" uniqKey="Illidge T" first="Tim M." last="Illidge">Tim M. Illidge</name><affiliation><nlm:aff id="af0038"><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>; Manchester,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Kono, Koji" sort="Kono, Koji" uniqKey="Kono K" first="Koji" last="Kono">Koji Kono</name><affiliation><nlm:aff id="af0041"><institution>Department of Surgery; National University of Singapore</institution>; Singapore,<country>Singapore</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0042"><institution>Cancer Science Institute of Singapore; National University of Singapore</institution>; Singapore,<country>Singapore</country></nlm:aff></affiliation></author><author><name sortKey="Korbelik, Mladen" sort="Korbelik, Mladen" uniqKey="Korbelik M" first="Mladen" last="Korbelik">Mladen Korbelik</name><affiliation><nlm:aff id="af0043"><institution>British Columbia Cancer Agency</institution>; Vancouver,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Krysko, Dmitri V" sort="Krysko, Dmitri V" uniqKey="Krysko D" first="Dmitri V." last="Krysko">Dmitri V. Krysko</name><affiliation><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><affiliation><nlm:aff id="af0046"><institution>Division of Cancer Medicine and Division of Research; Peter MacCallum Cancer Center; East Melbourne</institution>; Victoria,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Lowenstein, Pedro R" sort="Lowenstein, Pedro R" uniqKey="Lowenstein P" first="Pedro R." last="Lowenstein">Pedro R. Lowenstein</name><affiliation><nlm:aff id="af0017"><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>; Ann Arbor, MI<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Lugli, Enrico" sort="Lugli, Enrico" uniqKey="Lugli E" first="Enrico" last="Lugli">Enrico Lugli</name><affiliation><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>; Milan,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>; Rozzano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ma, Yuting" sort="Ma, Yuting" uniqKey="Ma Y" first="Yuting" last="Ma">Yuting Ma</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation><nlm:aff id="af0049"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff></affiliation></author><author><name sortKey="Manfredi, Angelo A" sort="Manfredi, Angelo A" uniqKey="Manfredi A" first="Angelo A." last="Manfredi">Angelo A. Manfredi</name><affiliation><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>; Milano,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>; Milano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Martins, Isabelle" sort="Martins, Isabelle" uniqKey="Martins I" first="Isabelle" last="Martins">Isabelle Martins</name><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0052"><institution>INSERM, U1030</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0053"><institution>Faculté de Médecine; Université Paris-Sud/Paris XI</institution>; Kremlin-Bicêtre,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mavilio, Domenico" sort="Mavilio, Domenico" uniqKey="Mavilio D" first="Domenico" last="Mavilio">Domenico Mavilio</name><affiliation><nlm:aff id="af0047"><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>; Milan,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0048"><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>; Rozzano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Menger, Laurie" sort="Menger, Laurie" uniqKey="Menger L" first="Laurie" last="Menger">Laurie Menger</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0054"><institution>Cancer Immunology Unit, Research Department of Haematology; University College London (UCL) Cancer Institute</institution>; London,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Merendino, Nicol" sort="Merendino, Nicol" uniqKey="Merendino N" first="Nicol" last="Merendino">Nicol Merendino</name><affiliation><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>; Viterbo,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Michaud, Michael" sort="Michaud, Michael" uniqKey="Michaud M" first="Michael" last="Michaud">Michael Michaud</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mignot, Gregoire" sort="Mignot, Gregoire" uniqKey="Mignot G" first="Gregoire" last="Mignot">Gregoire Mignot</name><affiliation><nlm:aff id="af0056"><institution>Cellular and Molecular Immunology and Endocrinology</institution>, Oniris; Nantes,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Mossman, Karen L" sort="Mossman, Karen L" uniqKey="Mossman K" first="Karen L." last="Mossman">Karen L. Mossman</name><affiliation><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Multhoff, Gabriele" sort="Multhoff, Gabriele" uniqKey="Multhoff G" first="Gabriele" last="Multhoff">Gabriele Multhoff</name><affiliation><nlm:aff id="af0059"><institution>Department of Radiation Oncology; Klinikum rechts der Isar; Technical University of Munich</institution>; Munich,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Oehler, Rudolf" sort="Oehler, Rudolf" uniqKey="Oehler R" first="Rudolf" last="Oehler">Rudolf Oehler</name><affiliation><nlm:aff id="af0060"><institution>Comprehensive Cancer Center; Medical University of Vienna</institution>; Vienna,<country>Austria</country></nlm:aff></affiliation></author><author><name sortKey="Palombo, Fabio" sort="Palombo, Fabio" uniqKey="Palombo F" first="Fabio" last="Palombo">Fabio Palombo</name><affiliation><nlm:aff id="af0012"><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0013"><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Panaretakis, Theocharis" sort="Panaretakis, Theocharis" uniqKey="Panaretakis T" first="Theocharis" last="Panaretakis">Theocharis Panaretakis</name><affiliation><nlm:aff id="af0061"><institution>Department of Oncology-Pathology; Karolinska Institute</institution>; Stockholm,<country>Sweden</country></nlm:aff></affiliation></author><author><name sortKey="Pol, Jonathan" sort="Pol, Jonathan" uniqKey="Pol J" first="Jonathan" last="Pol">Jonathan Pol</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Proietti, Enrico" sort="Proietti, Enrico" uniqKey="Proietti E" first="Enrico" last="Proietti">Enrico Proietti</name><affiliation><nlm:aff id="af0014"><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Ricci, Jean Ehrland" sort="Ricci, Jean Ehrland" uniqKey="Ricci J" first="Jean-Ehrland" last="Ricci">Jean-Ehrland Ricci</name><affiliation><nlm:aff id="af0062"><institution>INSERM; U1065</institution>; Nice,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0063"><institution>Equipe “Contrôle Métabolique des Morts Cellulaires,” Center Méditerranéen de Médecine Moléculaire (C3M)</institution>; Nice,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0064"><institution>Faculté de Médecine; Université de Nice Sophia Antipolis</institution>; Nice,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0065"><institution>Centre Hospitalier Universitaire de Nice</institution>; Nice,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Riganti, Chiara" sort="Riganti, Chiara" uniqKey="Riganti C" first="Chiara" last="Riganti">Chiara Riganti</name><affiliation><nlm:aff id="af0066"><institution>Department of Oncology and Subalpine Center for Research and Experimental Medicine (CeRMS); University of Turin</institution>; Turin,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Rovere Querini, Patrizia" sort="Rovere Querini, Patrizia" uniqKey="Rovere Querini P" first="Patrizia" last="Rovere-Querini">Patrizia Rovere-Querini</name><affiliation><nlm:aff id="af0050"><institution>University Vita-Salute San Raffaele</institution>; Milano,<country>Italy</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0051"><institution>San Raffaele Scientific Institute</institution>; Milano,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Rubartelli, Anna" sort="Rubartelli, Anna" uniqKey="Rubartelli A" first="Anna" last="Rubartelli">Anna Rubartelli</name><affiliation><nlm:aff id="af0067"><institution>Cell Biology Unit; Azienda Ospedaliera Universitaria San Martino</institution>;<institution>Istituto Nazionale per la Ricerca sul Cancro</institution>; Genova,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Sistigu, Antonella" sort="Sistigu, Antonella" uniqKey="Sistigu A" first="Antonella" last="Sistigu">Antonella Sistigu</name><affiliation><nlm:aff id="af0005"><institution>Regina Elena National Cancer Institute</institution>; Rome,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J." last="Smyth">Mark J. Smyth</name><affiliation><nlm:aff id="af0068"><institution>Immunology in Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute</institution>; Herston,<country>Australia</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0069"><institution>School of Medicine, University of Queensland</institution>; Herston,<country>Australia</country></nlm:aff></affiliation></author><author><name sortKey="Sonnemann, Juergen" sort="Sonnemann, Juergen" uniqKey="Sonnemann J" first="Juergen" last="Sonnemann">Juergen Sonnemann</name><affiliation><nlm:aff id="af0070"><institution>Department of Pediatric Haematology and Oncology; Jena University Hospital, Children's Clinic</institution>; Jena,<country>Germany</country></nlm:aff></affiliation></author><author><name sortKey="Spisek, Radek" sort="Spisek, Radek" uniqKey="Spisek R" first="Radek" last="Spisek">Radek Spisek</name><affiliation><nlm:aff id="af0027"><institution>Department of Immunology; 2<sup>nd</sup> Faculty of Medicine and University Hospital Motol, Charles University</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0028"><institution>Sotio</institution>; Prague,<country>Czech Republic</country></nlm:aff></affiliation></author><author><name sortKey="Stagg, John" sort="Stagg, John" uniqKey="Stagg J" first="John" last="Stagg">John Stagg</name><affiliation><nlm:aff id="af0071"><institution>Centre de Recherche du Center Hospitalier de l’Université de Montréal; Faculté de Pharmacie, Université de Montréal</institution>; Montréal,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Sukkurwala, Abdul Qader" sort="Sukkurwala, Abdul Qader" uniqKey="Sukkurwala A" first="Abdul Qader" last="Sukkurwala">Abdul Qader Sukkurwala</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0072"><institution>Department of Pathology, Dow International Medical College; Dow University of Health Sciences</institution>; Karachi,<country>Pakistan</country></nlm:aff></affiliation></author><author><name sortKey="Tartour, Eric" sort="Tartour, Eric" uniqKey="Tartour E" first="Eric" last="Tartour">Eric Tartour</name><affiliation><nlm:aff id="af0073"><institution>INSERM; U970</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Thorburn, Andrew" sort="Thorburn, Andrew" uniqKey="Thorburn A" first="Andrew" last="Thorburn">Andrew Thorburn</name><affiliation><nlm:aff id="af0075"><institution>Department of Pharmacology; University of Colorado School of Medicine</institution>; Aurora, CO<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Thorne, Stephen H" sort="Thorne, Stephen H" uniqKey="Thorne S" first="Stephen H." last="Thorne">Stephen H. Thorne</name><affiliation><nlm:aff id="af0033"><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Vandenabeele, Peter" sort="Vandenabeele, Peter" uniqKey="Vandenabeele P" first="Peter" last="Vandenabeele">Peter Vandenabeele</name><affiliation><nlm:aff id="af0044"><institution>VIB Inflammation Research Center</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0045"><institution>Department of Biomedical Molecular Biology; Ghent University</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0076"><institution>Methusalem Program; Ghent University</institution>; Ghent,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Velotti, Francesca" sort="Velotti, Francesca" uniqKey="Velotti F" first="Francesca" last="Velotti">Francesca Velotti</name><affiliation><nlm:aff id="af0055"><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>; Viterbo,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Workenhe, Samuel T" sort="Workenhe, Samuel T" uniqKey="Workenhe S" first="Samuel T." last="Workenhe">Samuel T. Workenhe</name><affiliation><nlm:aff id="af0057"><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0058"><institution>Institute for Infectious Disease Research; McMaster University</institution>; Hamilton,<country>Canada</country></nlm:aff></affiliation></author><author><name sortKey="Yang, Haining" sort="Yang, Haining" uniqKey="Yang H" first="Haining" last="Yang">Haining Yang</name><affiliation><nlm:aff id="af0077"><institution>University of Hawaii Cancer Center</institution>; Honolulu, HI<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Zong, Wei Xing" sort="Zong, Wei Xing" uniqKey="Zong W" first="Wei-Xing" last="Zong">Wei-Xing Zong</name><affiliation><nlm:aff id="af0078"><institution>Department of Molecular Genetics and Microbiology; Stony Brook University</institution>; Stony Brook, NY<country>USA</country></nlm:aff></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation><nlm:aff id="af0004"><institution>INSERM; U1015</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0079"><institution>Centre d’Investigation Clinique Biothérapie 507 (CICBT507); Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0003"><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0074"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>; Paris,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><affiliation><nlm:aff id="af0001"><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0002"><institution>INSERM; U1138</institution>; Paris,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0006"><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></nlm:aff></affiliation><affiliation><nlm:aff id="af0030"><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff></affiliation></author></analytic><series><title level="j">Oncoimmunology</title><idno type="ISSN">2162-4011</idno><idno type="eISSN">2162-402X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named “immunogenic cell death” (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defects in the components that underlie the capacity of the immune system to perceive cell death as immunogenic negatively influence disease outcome among cancer patients treated with ICD inducers. Thus, ICD has profound clinical and therapeutic implications. Unfortunately, the gold-standard approach to detect ICD relies on vaccination experiments involving immunocompetent murine models and syngeneic cancer cells, an approach that is incompatible with large screening campaigns. Here, we outline strategies conceived to detect surrogate markers of ICD <italic>in vitro</italic> and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine. </p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncoimmunology</journal-id><journal-id journal-id-type="iso-abbrev">Oncoimmunology</journal-id><journal-id journal-id-type="pmc">KONI</journal-id><journal-title-group><journal-title>Oncoimmunology</journal-title></journal-title-group><issn pub-type="ppub">2162-4011</issn><issn pub-type="epub">2162-402X</issn><publisher><publisher-name>Taylor & Francis</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25941621</article-id><article-id pub-id-type="pmc">4292729</article-id><article-id pub-id-type="publisher-id">955691</article-id><article-id pub-id-type="doi">10.4161/21624011.2014.955691</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group><subj-group><subject>Review</subject></subj-group></article-categories><title-group><article-title>Consensus guidelines for the detection of immunogenic cell death</article-title><alt-title alt-title-type="running-title">Definition and assessment of ICD</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kepp</surname><given-names>Oliver</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0003"><sup>3</sup></xref><xref ref-type="author-notes" rid="afn0001"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Senovilla</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0003"><sup>3</sup></xref><xref ref-type="aff" rid="af0004"><sup>4</sup></xref><xref ref-type="author-notes" rid="afn0001"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vitale</surname><given-names>Ilio</given-names></name><xref ref-type="aff" rid="af0005"><sup>5</sup></xref></contrib><contrib 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contrib-type="author"><name><surname>Korbelik</surname><given-names>Mladen</given-names></name><xref ref-type="aff" rid="af0043"><sup>43</sup></xref></contrib><contrib contrib-type="author"><name><surname>Krysko</surname><given-names>Dmitri V.</given-names></name><xref ref-type="aff" rid="af0044"><sup>44</sup></xref><xref ref-type="aff" rid="af0045"><sup>45</sup></xref></contrib><contrib contrib-type="author"><name><surname>Loi</surname><given-names>Sherene</given-names></name><xref ref-type="aff" rid="af0046"><sup>46</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lowenstein</surname><given-names>Pedro R.</given-names></name><xref ref-type="aff" rid="af0017"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lugli</surname><given-names>Enrico</given-names></name><xref ref-type="aff" rid="af0047"><sup>47</sup></xref><xref ref-type="aff" rid="af0048"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Yuting</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Madeo</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="af0049"><sup>49</sup></xref></contrib><contrib contrib-type="author"><name><surname>Manfredi</surname><given-names>Angelo A.</given-names></name><xref ref-type="aff" rid="af0050"><sup>50</sup></xref><xref ref-type="aff" rid="af0051"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martins</surname><given-names>Isabelle</given-names></name><xref ref-type="aff" rid="af0006"><sup>6</sup></xref><xref ref-type="aff" rid="af0052"><sup>52</sup></xref><xref ref-type="aff" rid="af0053"><sup>53</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mavilio</surname><given-names>Domenico</given-names></name><xref ref-type="aff" rid="af0047"><sup>47</sup></xref><xref ref-type="aff" rid="af0048"><sup>48</sup></xref></contrib><contrib contrib-type="author"><name><surname>Menger</surname><given-names>Laurie</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref><xref ref-type="aff" rid="af0054"><sup>54</sup></xref></contrib><contrib contrib-type="author"><name><surname>Merendino</surname><given-names>Nicolò</given-names></name><xref ref-type="aff" rid="af0055"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Michaud</surname><given-names>Michael</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mignot</surname><given-names>Gregoire</given-names></name><xref ref-type="aff" rid="af0056"><sup>56</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mossman</surname><given-names>Karen L.</given-names></name><xref ref-type="aff" rid="af0057"><sup>57</sup></xref><xref ref-type="aff" rid="af0058"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Multhoff</surname><given-names>Gabriele</given-names></name><xref ref-type="aff" rid="af0059"><sup>59</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oehler</surname><given-names>Rudolf</given-names></name><xref ref-type="aff" rid="af0060"><sup>60</sup></xref></contrib><contrib contrib-type="author"><name><surname>Palombo</surname><given-names>Fabio</given-names></name><xref ref-type="aff" rid="af0012"><sup>12</sup></xref><xref ref-type="aff" rid="af0013"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Panaretakis</surname><given-names>Theocharis</given-names></name><xref ref-type="aff" rid="af0061"><sup>61</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pol</surname><given-names>Jonathan</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Proietti</surname><given-names>Enrico</given-names></name><xref ref-type="aff" rid="af0014"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ricci</surname><given-names>Jean-Ehrland</given-names></name><xref ref-type="aff" rid="af0062"><sup>62</sup></xref><xref ref-type="aff" rid="af0063"><sup>63</sup></xref><xref ref-type="aff" rid="af0064"><sup>64</sup></xref><xref ref-type="aff" rid="af0065"><sup>65</sup></xref></contrib><contrib contrib-type="author"><name><surname>Riganti</surname><given-names>Chiara</given-names></name><xref ref-type="aff" rid="af0066"><sup>66</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rovere-Querini</surname><given-names>Patrizia</given-names></name><xref ref-type="aff" rid="af0050"><sup>50</sup></xref><xref ref-type="aff" rid="af0051"><sup>51</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rubartelli</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="af0067"><sup>67</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sistigu</surname><given-names>Antonella</given-names></name><xref ref-type="aff" rid="af0005"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Smyth</surname><given-names>Mark J.</given-names></name><xref ref-type="aff" rid="af0068"><sup>68</sup></xref><xref ref-type="aff" rid="af0069"><sup>69</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sonnemann</surname><given-names>Juergen</given-names></name><xref ref-type="aff" rid="af0070"><sup>70</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spisek</surname><given-names>Radek</given-names></name><xref ref-type="aff" rid="af0027"><sup>27</sup></xref><xref ref-type="aff" rid="af0028"><sup>28</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stagg</surname><given-names>John</given-names></name><xref ref-type="aff" rid="af0071"><sup>71</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sukkurwala</surname><given-names>Abdul Qader</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref><xref ref-type="aff" rid="af0072"><sup>72</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tartour</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="af0073"><sup>73</sup></xref><xref ref-type="aff" rid="af0074"><sup>74</sup></xref></contrib><contrib contrib-type="author"><name><surname>Thorburn</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="af0075"><sup>75</sup></xref></contrib><contrib contrib-type="author"><name><surname>Thorne</surname><given-names>Stephen H.</given-names></name><xref ref-type="aff" rid="af0033"><sup>33</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vandenabeele</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="af0044"><sup>44</sup></xref><xref ref-type="aff" rid="af0045"><sup>45</sup></xref><xref ref-type="aff" rid="af0076"><sup>76</sup></xref></contrib><contrib contrib-type="author"><name><surname>Velotti</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="af0055"><sup>55</sup></xref></contrib><contrib contrib-type="author"><name><surname>Workenhe</surname><given-names>Samuel T.</given-names></name><xref ref-type="aff" rid="af0057"><sup>57</sup></xref><xref ref-type="aff" rid="af0058"><sup>58</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Haining</given-names></name><xref ref-type="aff" rid="af0077"><sup>77</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zong</surname><given-names>Wei-Xing</given-names></name><xref ref-type="aff" rid="af0078"><sup>78</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zitvogel</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="af0004"><sup>4</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref><xref ref-type="aff" rid="af0079"><sup>79</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kroemer</surname><given-names>Guido</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0003"><sup>3</sup></xref><xref ref-type="aff" rid="af0030"><sup>30</sup></xref><xref ref-type="aff" rid="af0074"><sup>74</sup></xref><xref ref-type="author-notes" rid="afn0002"><sup>‡</sup></xref><xref ref-type="corresp" rid="an0001"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Galluzzi</surname><given-names>Lorenzo</given-names></name><xref ref-type="aff" rid="af0001"><sup>1</sup></xref><xref ref-type="aff" rid="af0002"><sup>2</sup></xref><xref ref-type="aff" rid="af0006"><sup>6</sup></xref><xref ref-type="aff" rid="af0030"><sup>30</sup></xref><xref ref-type="author-notes" rid="afn0002"><sup>‡</sup></xref><xref ref-type="corresp" rid="an0001"><sup>*</sup></xref></contrib><aff id="af0001"><label>1</label><institution>Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></aff><aff id="af0002"><label>2</label><institution>INSERM; U1138</institution>; Paris,<country>France</country></aff><aff id="af0003"><label>3</label><institution>Metabolomics and Cell Biology Platforms; Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></aff><aff id="af0004"><label>4</label><institution>INSERM; U1015</institution>; Villejuif,<country>France</country></aff><aff id="af0005"><label>5</label><institution>Regina Elena National Cancer Institute</institution>; Rome,<country>Italy</country></aff><aff id="af0006"><label>6</label><institution>Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></aff><aff id="af0007"><label>7</label><institution>Molecular Cell Biology Laboratory; Department of Immunology; Institute of Biomedical Sciences; University of São Paulo</institution>; São Paulo,<country>Brazil</country></aff><aff id="af0008"><label>8</label><institution>Cell Death Research and Therapy (CDRT) Laboratory; Department of Cellular and Molecular Medicine; University of Leuven</institution>; Leuven,<country>Belgium</country></aff><aff id="af0009"><label>9</label><institution>INSERM; UMR866</institution>; Dijon,<country>France</country></aff><aff id="af0010"><label>10</label><institution>Centre Georges François Leclerc</institution>; Dijon,<country>France</country></aff><aff id="af0011"><label>11</label><institution>Université de Bourgogne</institution>; Dijon,<country>France</country></aff><aff id="af0012"><label>12</label><institution>Departement of Internal Medicine and Medical Sciences; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></aff><aff id="af0013"><label>13</label><institution>Istituto Pasteur; Fondazione Cenci Bolognetti</institution>; Rome,<country>Italy</country></aff><aff id="af0014"><label>14</label><institution>Department of Hematology; Oncology and Molecular Medicine; Istituto Superiore di Sanità (ISS)</institution>; Rome,<country>Italy</country></aff><aff id="af0015"><label>15</label><institution>Laboratory of Molecular and Cellular Therapy (LMCT); Department of Biomedical Sciences Medical School of the Free University of Brussels (VUB)</institution>; Jette,<country>Belgium</country></aff><aff id="af0016"><label>16</label><institution>Faculty of Life Sciences; University of Manchester</institution>; Manchester,<country>UK</country></aff><aff id="af0017"><label>17</label><institution>Department of Neurosurgery and Cell and Developmental Biology; University of Michigan School of Medicine</institution>; Ann Arbor, MI<country>USA</country></aff><aff id="af0018"><label>18</label><institution>Department of Experimental Medicine; University of Rome La Sapienza</institution>; Rome,<country>Italy</country></aff><aff id="af0019"><label>19</label><institution>Laboratorio de Biología Celular y Molecular; Instituto de Histología y Embriología (IHEM); Facultad de Ciencias Médicas; Universidad Nacional de Cuyo; CONICET</institution>; Mendoza,<country>Argentina</country></aff><aff id="af0020"><label>20</label><institution>Université Pierre et Marie Curie/Paris VI</institution>; Paris,<country>France</country></aff><aff id="af0021"><label>21</label><institution>Equipe 13; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></aff><aff id="af0022"><label>22</label><institution>Department of Pathology; New York University School of Medicine</institution>; New York, NY<country>USA</country></aff><aff id="af0023"><label>23</label><institution>Department of Biological and Environmental Science and Technology (DiSTeBA); University of Salento</institution>; Lecce,<country>Italy</country></aff><aff id="af0024"><label>24</label><institution>Molecular and Cellular Biology Laboratory; Division of Basic Sciences; University of Crete Medical School</institution>; Heraklion,<country>Greece</country></aff><aff id="af0025"><label>25</label><institution>Institute of Molecular Biology and Biotechnology; Foundation of Research and Technology - Hellas</institution>; Heraklion,<country>Greece</country></aff><aff id="af0026"><label>26</label><institution>Department of Radiation Oncology; NewYork University School of Medicine and Langone Medical Center</institution>; New York, NY<country>USA</country></aff><aff id="af0027"><label>27</label><institution>Department of Immunology; 2<sup>nd</sup> Faculty of Medicine and University Hospital Motol, Charles University</institution>; Prague,<country>Czech Republic</country></aff><aff id="af0028"><label>28</label><institution>Sotio</institution>; Prague,<country>Czech Republic</country></aff><aff id="af0029"><label>29</label><institution>Department of Radiation Oncology; University Hospital Erlangen; University of Erlangen-Nürnberg</institution>; Erlangen,<country>Germany</country></aff><aff id="af0030"><label>30</label><institution>Université Paris Descartes/Paris V; Sorbonne Paris Cité</institution>; Paris,<country>France</country></aff><aff id="af0031"><label>31</label><institution>Laboratory of Integrative Cancer Immunology; Center de Recherche des Cordeliers</institution>; Paris,<country>France</country></aff><aff id="af0032"><label>32</label><institution>European Pancreas Center; Department of Surgery; University Hospital Heidelberg</institution>; Heidelberg,<country>Germany</country></aff><aff id="af0033"><label>33</label><institution>Department of Surgery; University of Pittsburgh</institution>; Pittsburgh, PA<country>USA</country></aff><aff id="af0034"><label>34</label><institution>Cancer Gene Therapy Group; Transplantation laboratory; Haartman Institute; University of Helsinki</institution>; Helsinki,<country>Finland</country></aff><aff id="af0035"><label>35</label><institution>Department of Internal Medicine 3; University of Erlangen-Nuremberg</institution>; Erlangen,<country>Germany</country></aff><aff id="af0036"><label>36</label><institution>Laboratory of Tumor Immunology and Biology; Center for Cancer Research; National Cancer Institute (NCI), National Institutes of Health (NIH)</institution>; Bethesda, MD<country>USA</country></aff><aff id="af0037"><label>37</label><institution>Institute of Clinical Chemistry and Clinical Pharmacology; University Hospital Bonn</institution>; Bonn,<country>Germany</country></aff><aff id="af0038"><label>38</label><institution>Faculty of Medical and Human Sciences, Institute of Cancer Studies; Manchester Academic Health Sciences Center; University of Manchester</institution>; Manchester,<country>UK</country></aff><aff id="af0039"><label>39</label><institution>Cancer Research and Biotherapy Center; Second Affiliated Hospital of Southeast University</institution>; Nanjing,<country>China</country></aff><aff id="af0040"><label>40</label><institution>Laboratory of Cancer Immunobiology; Earle A. Chiles Research Institute; Providence Portland Medical Center</institution>; Portland, OR<country>USA</country></aff><aff id="af0041"><label>41</label><institution>Department of Surgery; National University of Singapore</institution>; Singapore,<country>Singapore</country></aff><aff id="af0042"><label>42</label><institution>Cancer Science Institute of Singapore; National University of Singapore</institution>; Singapore,<country>Singapore</country></aff><aff id="af0043"><label>43</label><institution>British Columbia Cancer Agency</institution>; Vancouver,<country>Canada</country></aff><aff id="af0044"><label>44</label><institution>VIB Inflammation Research Center</institution>; Ghent,<country>Belgium</country></aff><aff id="af0045"><label>45</label><institution>Department of Biomedical Molecular Biology; Ghent University</institution>; Ghent,<country>Belgium</country></aff><aff id="af0046"><label>46</label><institution>Division of Cancer Medicine and Division of Research; Peter MacCallum Cancer Center; East Melbourne</institution>; Victoria,<country>Australia</country></aff><aff id="af0047"><label>47</label><institution>Unit of Clinical and Experimental Immunology; Humanitas Clinical and Research Center</institution>; Milan,<country>Italy</country></aff><aff id="af0048"><label>48</label><institution>Department of Medical Biotechnologies and Translational Medicine, University of Milan</institution>; Rozzano,<country>Italy</country></aff><aff id="af0049"><label>49</label><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></aff><aff id="af0050"><label>50</label><institution>University Vita-Salute San Raffaele</institution>; Milano,<country>Italy</country></aff><aff id="af0051"><label>51</label><institution>San Raffaele Scientific Institute</institution>; Milano,<country>Italy</country></aff><aff id="af0052"><label>52</label><institution>INSERM, U1030</institution>; Villejuif,<country>France</country></aff><aff id="af0053"><label>53</label><institution>Faculté de Médecine; Université Paris-Sud/Paris XI</institution>; Kremlin-Bicêtre,<country>France</country></aff><aff id="af0054"><label>54</label><institution>Cancer Immunology Unit, Research Department of Haematology; University College London (UCL) Cancer Institute</institution>; London,<country>UK</country></aff><aff id="af0055"><label>55</label><institution>Department of Ecological and Biological Sciences (DEB), Tuscia University</institution>; Viterbo,<country>Italy</country></aff><aff id="af0056"><label>56</label><institution>Cellular and Molecular Immunology and Endocrinology</institution>, Oniris; Nantes,<country>France</country></aff><aff id="af0057"><label>57</label><institution>Department of Pathology and Molecular Medicine; McMaster Immunology Research Center</institution>; Hamilton,<country>Canada</country></aff><aff id="af0058"><label>58</label><institution>Institute for Infectious Disease Research; McMaster University</institution>; Hamilton,<country>Canada</country></aff><aff id="af0059"><label>59</label><institution>Department of Radiation Oncology; Klinikum rechts der Isar; Technical University of Munich</institution>; Munich,<country>Germany</country></aff><aff id="af0060"><label>60</label><institution>Comprehensive Cancer Center; Medical University of Vienna</institution>; Vienna,<country>Austria</country></aff><aff id="af0061"><label>61</label><institution>Department of Oncology-Pathology; Karolinska Institute</institution>; Stockholm,<country>Sweden</country></aff><aff id="af0062"><label>62</label><institution>INSERM; U1065</institution>; Nice,<country>France</country></aff><aff id="af0063"><label>63</label><institution>Equipe “Contrôle Métabolique des Morts Cellulaires,” Center Méditerranéen de Médecine Moléculaire (C3M)</institution>; Nice,<country>France</country></aff><aff id="af0064"><label>64</label><institution>Faculté de Médecine; Université de Nice Sophia Antipolis</institution>; Nice,<country>France</country></aff><aff id="af0065"><label>65</label><institution>Centre Hospitalier Universitaire de Nice</institution>; Nice,<country>France</country></aff><aff id="af0066"><label>66</label><institution>Department of Oncology and Subalpine Center for Research and Experimental Medicine (CeRMS); University of Turin</institution>; Turin,<country>Italy</country></aff><aff id="af0067"><label>67</label><institution>Cell Biology Unit; Azienda Ospedaliera Universitaria San Martino</institution>;<institution>Istituto Nazionale per la Ricerca sul Cancro</institution>; Genova,<country>Italy</country></aff><aff id="af0068"><label>68</label><institution>Immunology in Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute</institution>; Herston,<country>Australia</country></aff><aff id="af0069"><label>69</label><institution>School of Medicine, University of Queensland</institution>; Herston,<country>Australia</country></aff><aff id="af0070"><label>70</label><institution>Department of Pediatric Haematology and Oncology; Jena University Hospital, Children's Clinic</institution>; Jena,<country>Germany</country></aff><aff id="af0071"><label>71</label><institution>Centre de Recherche du Center Hospitalier de l’Université de Montréal; Faculté de Pharmacie, Université de Montréal</institution>; Montréal,<country>Canada</country></aff><aff id="af0072"><label>72</label><institution>Department of Pathology, Dow International Medical College; Dow University of Health Sciences</institution>; Karachi,<country>Pakistan</country></aff><aff id="af0073"><label>73</label><institution>INSERM; U970</institution>; Paris,<country>France</country></aff><aff id="af0074"><label>74</label><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou; AP-HP</institution>; Paris,<country>France</country></aff><aff id="af0075"><label>75</label><institution>Department of Pharmacology; University of Colorado School of Medicine</institution>; Aurora, CO<country>USA</country></aff><aff id="af0076"><label>76</label><institution>Methusalem Program; Ghent University</institution>; Ghent,<country>Belgium</country></aff><aff id="af0077"><label>77</label><institution>University of Hawaii Cancer Center</institution>; Honolulu, HI<country>USA</country></aff><aff id="af0078"><label>78</label><institution>Department of Molecular Genetics and Microbiology; Stony Brook University</institution>; Stony Brook, NY<country>USA</country></aff><aff id="af0079"><label>79</label><institution>Centre d’Investigation Clinique Biothérapie 507 (CICBT507); Gustave Roussy Cancer Campus</institution>; Villejuif,<country>France</country></aff></contrib-group><author-notes><fn id="afn0001"><label>†</label><p>These authors equally contributed to this work</p></fn><fn id="afn0002"><label>‡</label><p>These authors share senior co-authorship.</p></fn><corresp id="an0001"><label>*</label>Correspondence to: Lorenzo Galluzzi; Email: <email xlink:href="deadoc@vodafone.it">deadoc@vodafone.it</email>; Guido Kroemer; Email: <email xlink:href="kroemer@orange.fr">kroemer@orange.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>10</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="collection"><year>2014</year></pub-date><volume>3</volume><issue>9</issue><elocation-id seq="20">e955691</elocation-id><history><date date-type="received"><day>4</day><month>8</month><year>2014</year></date><date date-type="accepted"><day>4</day><month>8</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 Taylor & Francis Group, LLC</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Taylor & Francis Group, LLC</copyright-holder></permissions><self-uri content-type="pdf" xlink:href="koni-03-e955691.pdf"></self-uri><abstract><p>Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we named “immunogenic cell death” (ICD). ICD is preceded or accompanied by the emission of a series of immunostimulatory damage-associated molecular patterns (DAMPs) in a precise spatiotemporal configuration. Several anticancer agents that have been successfully employed in the clinic for decades, including various chemotherapeutics and radiotherapy, can elicit ICD. Moreover, defects in the components that underlie the capacity of the immune system to perceive cell death as immunogenic negatively influence disease outcome among cancer patients treated with ICD inducers. Thus, ICD has profound clinical and therapeutic implications. Unfortunately, the gold-standard approach to detect ICD relies on vaccination experiments involving immunocompetent murine models and syngeneic cancer cells, an approach that is incompatible with large screening campaigns. Here, we outline strategies conceived to detect surrogate markers of ICD <italic>in vitro</italic> and to screen large chemical libraries for putative ICD inducers, based on a high-content, high-throughput platform that we recently developed. Such a platform allows for the detection of multiple DAMPs, like cell surface-exposed calreticulin, extracellular ATP and high mobility group box 1 (HMGB1), and/or the processes that underlie their emission, such as endoplasmic reticulum stress, autophagy and necrotic plasma membrane permeabilization. We surmise that this technology will facilitate the development of next-generation anticancer regimens, which kill malignant cells and simultaneously convert them into a cancer-specific therapeutic vaccine. </p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>ATP release</kwd><kwd>autophagy</kwd><kwd>calreticulin</kwd><kwd>endoplasmic reticulum stress</kwd><kwd>HMGB1</kwd><kwd>immunotherapy</kwd></kwd-group><kwd-group kwd-group-type="author"><title>Abbreviations</title><kwd>APC, antigen-presenting cell</kwd><kwd>ATF6, activating transcription factor 6</kwd><kwd>BAK1, BCL2-antagonist/killer 1</kwd><kwd>BAX, BCL2-associated X protein</kwd><kwd>BCL2, B-cell CLL/lymphoma 2 protein</kwd><kwd>CALR, calreticulin</kwd><kwd>CTL, cytotoxic T lymphocyte</kwd><kwd>Δψ<sub>m</sub>, mitochondrial transmembrane potential</kwd><kwd>DAMP, damage-associated molecular pattern</kwd><kwd>DAPI, 4′,6-diamidino-2-phenylindole</kwd><kwd>DiOC<sub>6</sub>(3), 3,3′-dihexyloxacarbocyanine iodide</kwd><kwd>EIF2A, eukaryotic translation initiation factor 2A</kwd><kwd>ER, endoplasmic reticulum</kwd><kwd>FLT3LG, fms-related tyrosine kinase 3 ligand</kwd><kwd>G3BP1, GTPase activating protein (SH3 domain) binding protein 1</kwd><kwd>GFP, green fluorescent protein</kwd><kwd>H2B, histone 2B</kwd><kwd>HMGB1, high mobility group box 1</kwd><kwd>HSP, heat shock protein</kwd><kwd>HSV-1, herpes simplex virus type I</kwd><kwd>ICD, immunogenic cell death</kwd><kwd>IFN, interferon</kwd><kwd>IL, interleukin</kwd><kwd>MOMP, mitochondrial outer membrane permeabilization</kwd><kwd>PDIA3, protein disulfide isomerase family A</kwd><kwd>member 3</kwd><kwd>PI, propidium iodide</kwd><kwd>RFP, red fluorescent protein</kwd><kwd>TLR, Toll-like receptor</kwd><kwd>XBP1, X-box binding protein 1</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="1"></table-count><ref-count count="288"></ref-count><page-count count="19"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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