Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies123
Identifieur interne : 000168 ( Pmc/Corpus ); précédent : 000167; suivant : 000169Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies123
Auteurs : Timothy J. Key ; Paul N. Appleby ; Ruth C. Travis ; Demetrius Albanes ; Anthony J. Alberg ; Aurelio Barricarte ; Amanda Black ; Heiner Boeing ; H Bas Bueno-De-Mesquita ; June M. Chan ; Chu Chen ; Michael B. Cook ; Jenny L. Donovan ; Pilar Galan ; Rebecca Gilbert ; Graham G. Giles ; Edward Giovannucci ; Gary E. Goodman ; Phyllis J. Goodman ; Marc J. Gunter ; Freddie C. Hamdy ; Markku Heliövaara ; Kathy J. Helzlsouer ; Brian E. Henderson ; Serge Hercberg ; Judy Hoffman-Bolton ; Robert N. Hoover ; Mattias Johansson ; Kay-Tee Khaw ; Irena B. King ; Paul Knekt ; Laurence N. Kolonel ; Loic Le Marchand ; Satu M Nnistö ; Richard M. Martin ; Haakon E. Meyer ; Alison M. Mondul ; Kristin A. Moy ; David E. Neal ; Marian L. Neuhouser ; Domenico Palli ; Elizabeth A. Platz ; Camille Pouchieu ; Harri Rissanen ; Jeannette M. Schenk ; Gianluca Severi ; Meir J. Stampfer ; Anne Tj Nneland ; Mathilde Touvier ; Antonia Trichopoulou ; Stephanie J. Weinstein ; Regina G. Ziegler ; Cindy Ke Zhou ; Naomi E. AllenSource :
- The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2015.
Abstract
Url:
DOI: 10.3945/ajcn.115.114306
PubMed: 26447150
PubMed Central: 4625592
Links to Exploration step
PMC:4625592Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref></title><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation><nlm:aff id="aff1">Cancer Epidemiology Unit, Nuffield Department of Population Health,</nlm:aff></affiliation></author><author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N" last="Appleby">Paul N. Appleby</name><affiliation><nlm:aff id="aff1">Cancer Epidemiology Unit, Nuffield Department of Population Health,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="aff1">Cancer Epidemiology Unit, Nuffield Department of Population Health,</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Alberg, Anthony J" sort="Alberg, Anthony J" uniqKey="Alberg A" first="Anthony J" last="Alberg">Anthony J. Alberg</name><affiliation><nlm:aff id="aff5">Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;</nlm:aff></affiliation></author><author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name><affiliation><nlm:aff id="aff7">Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;</nlm:aff></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="aff8">Department of Epidemiology, German Institute of Human Nutrition Potsdam–Rehbruecke, Nuthetal, Germany;</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name><affiliation><nlm:aff id="aff12">Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;</nlm:aff></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:aff id="aff13">Public Health Sciences Division, Program in Epidemiology,</nlm:aff></affiliation></author><author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name><affiliation><nlm:aff id="aff18">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="aff19">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:aff></affiliation></author><author><name sortKey="Gilbert, Rebecca" sort="Gilbert, Rebecca" uniqKey="Gilbert R" first="Rebecca" last="Gilbert">Rebecca Gilbert</name><affiliation><nlm:aff id="aff18">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff20">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="aff21">Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA;</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation><nlm:aff id="aff23">Departments of Epidemiology and Environmental Health, University of Washington, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name><affiliation><nlm:aff id="aff14">SWOG Statistical Center,</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="aff11">School of Public Health, Imperial College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Department of Surgery</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="aff24">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation><nlm:aff id="aff25">Prevention and Research Center Mercy Medical Center, Baltimore, MD;</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="aff26">Keck School of Medicine, University of Southern California, Los Angeles, CA;</nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="aff19">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:aff></affiliation></author><author><name sortKey="Hoffman Bolton, Judy" sort="Hoffman Bolton, Judy" uniqKey="Hoffman Bolton J" first="Judy" last="Hoffman-Bolton">Judy Hoffman-Bolton</name><affiliation><nlm:aff id="aff27">George W Comstock Center for Public Health Research and Prevention, Hagerstown, MD;</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:aff id="aff28">International Agency for Research on Cancer, Lyon, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff29">Department for Biobank Research, Umeå University, Umeå, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff wicri:cut=" and" id="aff30">Department of Public Health and Primary Care</nlm:aff></affiliation></author><author><name sortKey="King, Irena B" sort="King, Irena B" uniqKey="King I" first="Irena B" last="King">Irena B. King</name><affiliation><nlm:aff id="aff15">Public Health Sciences Core Laboratories,</nlm:aff></affiliation><affiliation><nlm:aff id="aff40">Department of Internal Medicine, University of New Mexico, Albuquerque, NM</nlm:aff></affiliation></author><author><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name><affiliation><nlm:aff id="aff32">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:aff id="aff33">University of Hawaii Cancer Center, Honolulu, HI;</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="aff33">University of Hawaii Cancer Center, Honolulu, HI;</nlm:aff></affiliation></author><author><name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name><affiliation><nlm:aff id="aff24">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name><affiliation><nlm:aff id="aff18">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="aff35">National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Meyer, Haakon E" sort="Meyer, Haakon E" uniqKey="Meyer H" first="Haakon E" last="Meyer">Haakon E. Meyer</name><affiliation><nlm:aff id="aff36">Department of Community Medicine, Faculty of Medicine, University of Oslo and Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;</nlm:aff></affiliation></author><author><name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M" last="Mondul">Alison M. Mondul</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Moy, Kristin A" sort="Moy, Kristin A" uniqKey="Moy K" first="Kristin A" last="Moy">Kristin A. Moy</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name><affiliation><nlm:aff id="aff31">Department of Oncology, University of Cambridge, Cambridge, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L" last="Neuhouser">Marian L. Neuhouser</name><affiliation><nlm:aff wicri:cut=", and" id="aff16">Division of Public Health Sciences</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="aff37">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Florence, Italy;</nlm:aff></affiliation></author><author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name><affiliation><nlm:aff id="aff5">Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</nlm:aff></affiliation></author><author><name sortKey="Pouchieu, Camille" sort="Pouchieu, Camille" uniqKey="Pouchieu C" first="Camille" last="Pouchieu">Camille Pouchieu</name><affiliation><nlm:aff id="aff20">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Rissanen, Harri" sort="Rissanen, Harri" uniqKey="Rissanen H" first="Harri" last="Rissanen">Harri Rissanen</name><affiliation><nlm:aff id="aff32">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M" last="Schenk">Jeannette M. Schenk</name><affiliation><nlm:aff id="aff17">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="aff20">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:aff id="aff21">Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA;</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:aff id="aff38">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;</nlm:aff></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:aff id="aff19">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:aff></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:aff wicri:cut=" and" id="aff39">Hellenic Health Foundation and Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J" last="Weinstein">Stephanie J. Weinstein</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Zhou, Cindy Ke" sort="Zhou, Cindy Ke" uniqKey="Zhou C" first="Cindy Ke" last="Zhou">Cindy Ke Zhou</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name><affiliation><nlm:aff id="aff3">Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26447150</idno><idno type="pmc">4625592</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625592</idno><idno type="RBID">PMC:4625592</idno><idno type="doi">10.3945/ajcn.115.114306</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000168</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000168</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>3</sup></xref></title><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation><nlm:aff id="aff1">Cancer Epidemiology Unit, Nuffield Department of Population Health,</nlm:aff></affiliation></author><author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N" last="Appleby">Paul N. Appleby</name><affiliation><nlm:aff id="aff1">Cancer Epidemiology Unit, Nuffield Department of Population Health,</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="aff1">Cancer Epidemiology Unit, Nuffield Department of Population Health,</nlm:aff></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Alberg, Anthony J" sort="Alberg, Anthony J" uniqKey="Alberg A" first="Anthony J" last="Alberg">Anthony J. Alberg</name><affiliation><nlm:aff id="aff5">Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</nlm:aff></affiliation><affiliation><nlm:aff id="aff6">Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;</nlm:aff></affiliation></author><author><name sortKey="Barricarte, Aurelio" sort="Barricarte, Aurelio" uniqKey="Barricarte A" first="Aurelio" last="Barricarte">Aurelio Barricarte</name><affiliation><nlm:aff id="aff7">Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;</nlm:aff></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:aff id="aff8">Department of Epidemiology, German Institute of Human Nutrition Potsdam–Rehbruecke, Nuthetal, Germany;</nlm:aff></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name><affiliation><nlm:aff id="aff12">Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;</nlm:aff></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:aff id="aff13">Public Health Sciences Division, Program in Epidemiology,</nlm:aff></affiliation></author><author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name><affiliation><nlm:aff id="aff18">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:aff id="aff19">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:aff></affiliation></author><author><name sortKey="Gilbert, Rebecca" sort="Gilbert, Rebecca" uniqKey="Gilbert R" first="Rebecca" last="Gilbert">Rebecca Gilbert</name><affiliation><nlm:aff id="aff18">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:aff id="aff20">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="aff21">Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA;</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Goodman, Gary E" sort="Goodman, Gary E" uniqKey="Goodman G" first="Gary E" last="Goodman">Gary E. Goodman</name><affiliation><nlm:aff id="aff23">Departments of Epidemiology and Environmental Health, University of Washington, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Goodman, Phyllis J" sort="Goodman, Phyllis J" uniqKey="Goodman P" first="Phyllis J" last="Goodman">Phyllis J. Goodman</name><affiliation><nlm:aff id="aff14">SWOG Statistical Center,</nlm:aff></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:aff id="aff11">School of Public Health, Imperial College, London, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Department of Surgery</nlm:aff></affiliation></author><author><name sortKey="Heliovaara, Markku" sort="Heliovaara, Markku" uniqKey="Heliovaara M" first="Markku" last="Heliövaara">Markku Heliövaara</name><affiliation><nlm:aff id="aff24">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation><nlm:aff id="aff25">Prevention and Research Center Mercy Medical Center, Baltimore, MD;</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="aff26">Keck School of Medicine, University of Southern California, Los Angeles, CA;</nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="aff19">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:aff></affiliation></author><author><name sortKey="Hoffman Bolton, Judy" sort="Hoffman Bolton, Judy" uniqKey="Hoffman Bolton J" first="Judy" last="Hoffman-Bolton">Judy Hoffman-Bolton</name><affiliation><nlm:aff id="aff27">George W Comstock Center for Public Health Research and Prevention, Hagerstown, MD;</nlm:aff></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:aff id="aff28">International Agency for Research on Cancer, Lyon, France;</nlm:aff></affiliation><affiliation><nlm:aff id="aff29">Department for Biobank Research, Umeå University, Umeå, Sweden;</nlm:aff></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:aff wicri:cut=" and" id="aff30">Department of Public Health and Primary Care</nlm:aff></affiliation></author><author><name sortKey="King, Irena B" sort="King, Irena B" uniqKey="King I" first="Irena B" last="King">Irena B. King</name><affiliation><nlm:aff id="aff15">Public Health Sciences Core Laboratories,</nlm:aff></affiliation><affiliation><nlm:aff id="aff40">Department of Internal Medicine, University of New Mexico, Albuquerque, NM</nlm:aff></affiliation></author><author><name sortKey="Knekt, Paul" sort="Knekt, Paul" uniqKey="Knekt P" first="Paul" last="Knekt">Paul Knekt</name><affiliation><nlm:aff id="aff32">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Kolonel, Laurence N" sort="Kolonel, Laurence N" uniqKey="Kolonel L" first="Laurence N" last="Kolonel">Laurence N. Kolonel</name><affiliation><nlm:aff id="aff33">University of Hawaii Cancer Center, Honolulu, HI;</nlm:aff></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:aff id="aff33">University of Hawaii Cancer Center, Honolulu, HI;</nlm:aff></affiliation></author><author><name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name><affiliation><nlm:aff id="aff24">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name><affiliation><nlm:aff id="aff18">School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="aff34">Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom;</nlm:aff></affiliation><affiliation><nlm:aff id="aff35">National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Meyer, Haakon E" sort="Meyer, Haakon E" uniqKey="Meyer H" first="Haakon E" last="Meyer">Haakon E. Meyer</name><affiliation><nlm:aff id="aff36">Department of Community Medicine, Faculty of Medicine, University of Oslo and Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;</nlm:aff></affiliation></author><author><name sortKey="Mondul, Alison M" sort="Mondul, Alison M" uniqKey="Mondul A" first="Alison M" last="Mondul">Alison M. Mondul</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Moy, Kristin A" sort="Moy, Kristin A" uniqKey="Moy K" first="Kristin A" last="Moy">Kristin A. Moy</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name><affiliation><nlm:aff id="aff31">Department of Oncology, University of Cambridge, Cambridge, United Kingdom;</nlm:aff></affiliation></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L" last="Neuhouser">Marian L. Neuhouser</name><affiliation><nlm:aff wicri:cut=", and" id="aff16">Division of Public Health Sciences</nlm:aff></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:aff id="aff37">Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Florence, Italy;</nlm:aff></affiliation></author><author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name><affiliation><nlm:aff id="aff5">Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</nlm:aff></affiliation></author><author><name sortKey="Pouchieu, Camille" sort="Pouchieu, Camille" uniqKey="Pouchieu C" first="Camille" last="Pouchieu">Camille Pouchieu</name><affiliation><nlm:aff id="aff20">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Rissanen, Harri" sort="Rissanen, Harri" uniqKey="Rissanen H" first="Harri" last="Rissanen">Harri Rissanen</name><affiliation><nlm:aff id="aff32">National Institute for Health and Welfare, Helsinki, Finland;</nlm:aff></affiliation></author><author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M" last="Schenk">Jeannette M. Schenk</name><affiliation><nlm:aff id="aff17">Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA;</nlm:aff></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:aff id="aff20">Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</nlm:aff></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:aff id="aff21">Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA;</nlm:aff></affiliation><affiliation><nlm:aff id="aff22">Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</nlm:aff></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:aff id="aff38">Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;</nlm:aff></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:aff id="aff19">Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</nlm:aff></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:aff wicri:cut=" and" id="aff39">Hellenic Health Foundation and Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece</nlm:aff></affiliation></author><author><name sortKey="Weinstein, Stephanie J" sort="Weinstein, Stephanie J" uniqKey="Weinstein S" first="Stephanie J" last="Weinstein">Stephanie J. Weinstein</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Zhou, Cindy Ke" sort="Zhou, Cindy Ke" uniqKey="Zhou C" first="Cindy Ke" last="Zhou">Cindy Ke Zhou</name><affiliation><nlm:aff id="aff4">Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</nlm:aff></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name><affiliation><nlm:aff id="aff3">Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;</nlm:aff></affiliation></author></analytic><series><title level="j">The American Journal of Clinical Nutrition</title><idno type="ISSN">0002-9165</idno><idno type="eISSN">1938-3207</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.</p><p><bold>Objective:</bold> The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, α-tocopherol, and γ-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors.</p><p><bold>Design:</bold> Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets.</p><p><bold>Results:</bold> Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; <italic>P</italic>-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; <italic>P</italic>-trend = 0.015). For α-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; <italic>P</italic>-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; <italic>P</italic>-trend = 0.001). γ-Tocopherol was not associated with risk.</p><p><bold>Conclusions:</bold> Overall prostate cancer risk was positively associated with retinol and inversely associated with α-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and α-tocopherol. Whether these associations reflect causal relations is unclear.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Clin Nutr</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Clin. Nutr</journal-id><journal-id journal-id-type="publisher-id">ajcn</journal-id><journal-title-group><journal-title>The American Journal of Clinical Nutrition</journal-title></journal-title-group><issn pub-type="ppub">0002-9165</issn><issn pub-type="epub">1938-3207</issn><publisher><publisher-name>American Society for Nutrition</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26447150</article-id><article-id pub-id-type="pmc">4625592</article-id><article-id pub-id-type="publisher-id">114306</article-id><article-id pub-id-type="doi">10.3945/ajcn.115.114306</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cancer</subject></subj-group></article-categories><title-group><article-title>Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="author-notes" 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ref-type="aff" rid="aff32"><sup>35</sup></xref></contrib><contrib contrib-type="author"><name><surname>Schenk</surname><given-names>Jeannette M</given-names></name><xref ref-type="aff" rid="aff17"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Severi</surname><given-names>Gianluca</given-names></name><xref ref-type="aff" rid="aff20"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Stampfer</surname><given-names>Meir J</given-names></name><xref ref-type="aff" rid="aff21"><sup>24</sup></xref><xref ref-type="aff" rid="aff22"><sup>25</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tjønneland</surname><given-names>Anne</given-names></name><xref ref-type="aff" rid="aff38"><sup>41</sup></xref></contrib><contrib contrib-type="author"><name><surname>Touvier</surname><given-names>Mathilde</given-names></name><xref ref-type="aff" rid="aff19"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trichopoulou</surname><given-names>Antonia</given-names></name><xref ref-type="aff" rid="aff39"><sup>42</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weinstein</surname><given-names>Stephanie J</given-names></name><xref ref-type="aff" rid="aff4"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ziegler</surname><given-names>Regina G</given-names></name><xref ref-type="aff" rid="aff4"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Cindy Ke</given-names></name><xref ref-type="aff" rid="aff4"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Allen</surname><given-names>Naomi E</given-names></name><xref ref-type="aff" rid="aff3"><sup>6</sup></xref></contrib><on-behalf-of>on behalf of the Endogenous Hormones Nutritional BiomarkersProstate Cancer Collaborative Group</on-behalf-of><aff id="aff1"><label>4</label>Cancer Epidemiology Unit, Nuffield Department of Population Health,</aff><aff id="aff2"><label>5</label>Department of Surgery, and</aff><aff id="aff3"><label>6</label>Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;</aff><aff id="aff4"><label>7</label>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</aff><aff id="aff5"><label>8</label>Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</aff><aff id="aff6"><label>9</label>Hollings Cancer Center, Medical University of South Carolina, Charleston, SC;</aff><aff id="aff7"><label>10</label>Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;</aff><aff id="aff8"><label>11</label>Department of Epidemiology, German Institute of Human Nutrition Potsdam–Rehbruecke, Nuthetal, Germany;</aff><aff id="aff9"><label>12</label>National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands;</aff><aff id="aff10"><label>13</label>Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands;</aff><aff id="aff11"><label>14</label>School of Public Health, Imperial College, London, United Kingdom;</aff><aff id="aff12"><label>15</label>Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;</aff><aff id="aff13"><label>16</label>Public Health Sciences Division, Program in Epidemiology,</aff><aff id="aff14"><label>17</label>SWOG Statistical Center,</aff><aff id="aff15"><label>18</label>Public Health Sciences Core Laboratories,</aff><aff id="aff16"><label>19</label>Division of Public Health Sciences, and</aff><aff id="aff17"><label>20</label>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA;</aff><aff id="aff18"><label>21</label>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom;</aff><aff id="aff19"><label>22</label>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team (Nutritional Epidemiology Research Team), Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, Bobigny, France;</aff><aff id="aff20"><label>23</label>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</aff><aff id="aff21"><label>24</label>Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA;</aff><aff id="aff22"><label>25</label>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</aff><aff id="aff23"><label>26</label>Departments of Epidemiology and Environmental Health, University of Washington, Seattle, WA;</aff><aff id="aff24"><label>27</label>National Institute for Health and Welfare, Helsinki, Finland;</aff><aff id="aff25"><label>28</label>Prevention and Research Center Mercy Medical Center, Baltimore, MD;</aff><aff id="aff26"><label>29</label>Keck School of Medicine, University of Southern California, Los Angeles, CA;</aff><aff id="aff27"><label>30</label>George W Comstock Center for Public Health Research and Prevention, Hagerstown, MD;</aff><aff id="aff28"><label>31</label>International Agency for Research on Cancer, Lyon, France;</aff><aff id="aff29"><label>32</label>Department for Biobank Research, Umeå University, Umeå, Sweden;</aff><aff id="aff30"><label>33</label>Department of Public Health and Primary Care and</aff><aff id="aff31"><label>34</label>Department of Oncology, University of Cambridge, Cambridge, United Kingdom;</aff><aff id="aff32"><label>35</label>National Institute for Health and Welfare, Helsinki, Finland;</aff><aff id="aff33"><label>36</label>University of Hawaii Cancer Center, Honolulu, HI;</aff><aff id="aff34"><label>37</label>Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom;</aff><aff id="aff35"><label>38</label>National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;</aff><aff id="aff36"><label>39</label>Department of Community Medicine, Faculty of Medicine, University of Oslo and Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;</aff><aff id="aff37"><label>40</label>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Florence, Italy;</aff><aff id="aff38"><label>41</label>Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark;</aff><aff id="aff39"><label>42</label>Hellenic Health Foundation and Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece and</aff><aff id="aff40"><label>43</label>Department of Internal Medicine, University of New Mexico, Albuquerque, NM</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>To whom correspondence should be addressed. E-mail: <email>tim.key@ceu.ox.ac.uk</email>.</corresp><fn id="fn1" fn-type="supported-by"><label>1</label><p>Supported by Cancer Research UK grants C8221/A19170 and C570/A11691. Funding for the collaborating studies was as follows. Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: Supported in part by the Intramural Research Program of the NIH and the National Cancer Institute; also, this research was supported by US Public Health Service contracts N01-CN-45165, N01-RC-45035, N01-RC-37004, and HHSN261201000006C from the National Cancer Institute, Department of Health and Human Services. β-Carotene and Retinol Efficacy Trial: Supported by U01 CA63673, R01 CA96789, and N01 PC35142, all from the NIH, Department of Health and Human Services. CLUE I and II: Supported by CA 94028 from the National Cancer Institute, NIH. European Prospective Investigation into Cancer and Nutrition–Greece: Supported by the Hellenic Health Foundation. European Prospective Investigation into Cancer and Nutrition–Netherlands: Supported by the Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch Zorg Onderzoek Nederland, World Cancer Research Fund, Statistics Netherlands. Health Professionals Follow-Up Study: Supported by CA 55075 and CA 72036 from the National Cancer Institute and the NIH. Janus: The serum analysis of vitamins was supported by a grant from the Norwegian Cancer Society and the Throne Holst Foundation. Melbourne Collaborative Cohort Study (MCCS): Cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian National Health and Medical Research Council grants 209057, 251553, and 504711 and by infrastructure provided by Cancer Council Victoria. Multiethnic Cohort: Supported by National Cancer Institute grants P01 CA 33619, R37 CA 54281, and 1-UM1-CA164973. Prostate Cancer Prevention Trial: Supported by National Cancer Institute and NIH, CA37429 and P01 CA108964. Prostate testing for cancer and Treatment trial: Funded by the United Kingdom National Institute for Health Research Health Technology Assessment Programme (projects 96/20/06, 96/20/99, <ext-link ext-link-type="uri" xlink:href="www.hta/1230">www.hta/1230</ext-link>); the views and opinions expressed therein are those of the authors and do not necessarily reflect those of the Department of Health. The University of Bristol Integrated Epidemiology Unit is supported by the Medical Research Council and the University of Bristol. The Bristol Nutrition Biomedical Research Unit is funded by the National Institute for Health Research and is a partnership between the University Hospitals Bristol National Health Service Foundation Trust and the University of Bristol. SU.VI.MAX, SUpplémentation en VItamines et Minéraux Anti-oXydants trial: Supported by the Direction Générale de la Santé (French Ministry of Health) for laboratory assays.</p></fn><fn id="fn2"><label>2</label><p>The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.</p></fn><fn id="fn3"><label>3</label><p>Supplemental Tables 1–3 and Supplemental Figures 1–30 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at <ext-link ext-link-type="uri" xlink:href="http://ajcn.nutrition.org">http://ajcn.nutrition.org</ext-link>.</p></fn></author-notes><pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>7</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>102</volume><issue>5</issue><fpage>1142</fpage><lpage>1157</lpage><history><date date-type="received"><day>1</day><month>5</month><year>2015</year></date><date date-type="accepted"><day>1</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 American Society for Nutrition</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p><bold>Background:</bold> Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.</p><p><bold>Objective:</bold> The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, α-tocopherol, and γ-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors.</p><p><bold>Design:</bold> Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets.</p><p><bold>Results:</bold> Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; <italic>P</italic>-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; <italic>P</italic>-trend = 0.015). For α-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; <italic>P</italic>-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; <italic>P</italic>-trend = 0.001). γ-Tocopherol was not associated with risk.</p><p><bold>Conclusions:</bold> Overall prostate cancer risk was positively associated with retinol and inversely associated with α-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and α-tocopherol. Whether these associations reflect causal relations is unclear.</p></abstract><kwd-group><title>Keywords:</title><kwd>prostate cancer</kwd><kwd>carotenoids</kwd><kwd>retinol</kwd><kwd>tocopherols</kwd><kwd>vitamin E</kwd><kwd>vitamin A</kwd><kwd>pooled analysis</kwd><kwd>nested case-control study</kwd><kwd>biomarkers</kwd></kwd-group><counts><page-count count="16"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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