Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)
Identifieur interne : 002587 ( Pmc/Checkpoint ); précédent : 002586; suivant : 002588Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)
Auteurs : E. S. Siris [États-Unis] ; S. Gehlbach [États-Unis] ; J. D. Adachi [Canada] ; S. Boonen [Belgique] ; R. D. Chapurlat [France] ; J. E. Compston [Royaume-Uni] ; C. Cooper [Royaume-Uni] ; P. Delmas [France] ; A. Díez-Pérez [Espagne] ; F. H. Hooven [États-Unis] ; A. Z. Lacroix [États-Unis] ; J. C. Netelenbos [Pays-Bas] ; J. Pfeilschifter [Allemagne] ; M. Rossini [Italie] ; C. Roux [France] ; K. G. Saag [États-Unis] ; P. Sambrook [Australie] ; S. Silverman [États-Unis] ; N. B. Watts [États-Unis] ; A. Wyman [États-Unis] ; S. L. Greenspan [États-Unis]Source :
- Osteoporosis International [ 0937-941X ] ; 2010.
Abstract
We compared self-perception of fracture risk with actual risk among 60,393 postmenopausal women aged ≥55 years, using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Most postmenopausal women with risk factors failed to appreciate their actual risk for fracture. Improved education about osteoporosis risk factors is needed.
This study seeks to compare self-perception of fracture risk with actual risk among postmenopausal women using data from GLOW.
GLOW is an international, observational, cohort study involving 723 physician practices in 17 sites in ten countries in Europe, North America, and Australia. Participants included 60,393 women ≥55 years attended by their physician during the previous 24 months. The sample was enriched so that two thirds were ≥65 years. Baseline surveys were mailed October 2006 to February 2008. Main outcome measures were self-perception of fracture risk in women with elevated risk vs women of the same age and frequency of risk factors for fragility fracture.
In the overall study population, 19% (10,951/58,434) of women rated their risk of fracture as a little/much higher than that of women of the same age; 46% (27,138/58,434) said it was similar; 35% (20,345/58,434) believed it to be a little/much lower. Among women whose actual risk was increased based on the presence of any one of seven risk factors for fracture, the proportion who recognized their increased risk ranged from 19% for smokers to 39% for current users of glucocorticoid medication. Only 33% (4,185/12,612) of those with ≥2 risk factors perceived themselves as being at higher risk. Among women reporting a diagnosis of osteopenia or osteoporosis, only 25% and 43%, respectively, thought their risk was increased.
In this international, observational study, most postmenopausal women with risk factors failed to appreciate their actual risk for fracture.
Url:
DOI: 10.1007/s00198-010-1211-8
PubMed: 20358360
PubMed Central: 3017306
Affiliations:
- Allemagne, Australie, Belgique, Canada, Espagne, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Alabama, Angleterre, Angleterre de l'Est, Auvergne-Rhône-Alpes, Californie, Catalogne, Hollande-Septentrionale, Massachusetts, Nouvelle-Galles du Sud, Ohio, Ontario, Oxfordshire, Pennsylvanie, Rhône-Alpes, Washington (État), État de New York, Île-de-France
- Amsterdam, Barcelone, Cambridge, Hamilton (Ontario), Lyon, Oxford, Paris
- Université McMaster, Université d'Oxford, Université de Cambridge
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Gehlbach</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Outcomes Research, UMASS Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Adachi, J D" sort="Adachi, J D" uniqKey="Adachi J" first="J. D." last="Adachi">J. D. Adachi</name><affiliation wicri:level="4"><nlm:aff id="Aff2">St. Joseph’s Hospital, McMaster University, Hamilton, ON Canada</nlm:aff><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Boonen, S" sort="Boonen, S" uniqKey="Boonen S" first="S." last="Boonen">S. 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Cooper</name><affiliation wicri:level="1"><nlm:aff id="Aff6">MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff7">Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Musculoskeletal Sciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Delmas, P" sort="Delmas, P" uniqKey="Delmas P" first="P." last="Delmas">P. Delmas</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Diez Perez, A" sort="Diez Perez, A" uniqKey="Diez Perez A" first="A." last="Díez-Pérez">A. Díez-Pérez</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Department of Medicine, Hospital del Mar-IMIM-Autonomous, University of Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, Hospital del Mar-IMIM-Autonomous, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hooven, F H" sort="Hooven, F H" uniqKey="Hooven F" first="F. H." last="Hooven">F. H. Hooven</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Outcomes Research, UMASS Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Lacroix, A Z" sort="Lacroix, A Z" uniqKey="Lacroix A" first="A. Z." last="Lacroix">A. Z. Lacroix</name><affiliation wicri:level="2"><nlm:aff id="Aff11">Fred Hutchinson Cancer Research Center, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Netelenbos, J C" sort="Netelenbos, J C" uniqKey="Netelenbos J" first="J. C." last="Netelenbos">J. C. Netelenbos</name><affiliation wicri:level="3"><nlm:aff id="Aff12">Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pfeilschifter, J" sort="Pfeilschifter, J" uniqKey="Pfeilschifter J" first="J." last="Pfeilschifter">J. Pfeilschifter</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Rossini, M" sort="Rossini, M" uniqKey="Rossini M" first="M." last="Rossini">M. Rossini</name><affiliation wicri:level="1"><nlm:aff id="Aff14">Department of Rheumatology, University of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Rheumatology, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Roux, C" sort="Roux, C" uniqKey="Roux C" first="C." last="Roux">C. Roux</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris Descartes University, Cochin Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Saag, K G" sort="Saag, K G" uniqKey="Saag K" first="K. G." last="Saag">K. G. Saag</name><affiliation wicri:level="2"><nlm:aff id="Aff16">University of Alabama-Birmingham, Birmingham, AL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>University of Alabama-Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Sambrook, P" sort="Sambrook, P" uniqKey="Sambrook P" first="P." last="Sambrook">P. Sambrook</name><affiliation wicri:level="2"><nlm:aff id="Aff17">University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, NSW Australia</nlm:aff><country>Australie</country><placeName><region type="state">Nouvelle-Galles du Sud</region></placeName><wicri:cityArea>University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney</wicri:cityArea></affiliation></author><author><name sortKey="Silverman, S" sort="Silverman, S" uniqKey="Silverman S" first="S." last="Silverman">S. Silverman</name><affiliation wicri:level="2"><nlm:aff id="Aff18">Department of Rheumatology, Cedars-Sinai/UCLA, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Rheumatology, Cedars-Sinai/UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Watts, N B" sort="Watts, N B" uniqKey="Watts N" first="N. B." last="Watts">N. B. Watts</name><affiliation wicri:level="2"><nlm:aff id="Aff19">Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Wyman, A" sort="Wyman, A" uniqKey="Wyman A" first="A." last="Wyman">A. Wyman</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Outcomes Research, UMASS Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Greenspan, S L" sort="Greenspan, S L" uniqKey="Greenspan S" first="S. L." last="Greenspan">S. L. Greenspan</name><affiliation wicri:level="2"><nlm:aff id="Aff10">University of Pittsburgh, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20358360</idno><idno type="pmc">3017306</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017306</idno><idno type="RBID">PMC:3017306</idno><idno type="doi">10.1007/s00198-010-1211-8</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000E02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E02</idno><idno type="wicri:Area/Pmc/Curation">000C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C63</idno><idno type="wicri:Area/Pmc/Checkpoint">002587</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002587</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)</title><author><name sortKey="Siris, E S" sort="Siris, E S" uniqKey="Siris E" first="E. S." last="Siris">E. S. Siris</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Medicine, Columbia University Medical Center, 180 Fort Washington Avenue, Harkness Pavilion 9-964, New York, NY 10032 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Columbia University Medical Center, 180 Fort Washington Avenue, Harkness Pavilion 9-964, New York</wicri:cityArea></affiliation></author><author><name sortKey="Gehlbach, S" sort="Gehlbach, S" uniqKey="Gehlbach S" first="S." last="Gehlbach">S. Gehlbach</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Outcomes Research, UMASS Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Adachi, J D" sort="Adachi, J D" uniqKey="Adachi J" first="J. D." last="Adachi">J. D. Adachi</name><affiliation wicri:level="4"><nlm:aff id="Aff2">St. Joseph’s Hospital, McMaster University, Hamilton, ON Canada</nlm:aff><orgName type="university">Université McMaster</orgName><country>Canada</country><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Boonen, S" sort="Boonen, S" uniqKey="Boonen S" first="S." last="Boonen">S. Boonen</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Leuven University Center for Metabolic Bone Diseases, Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Leuven University Center for Metabolic Bone Diseases, Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Chapurlat, R D" sort="Chapurlat, R D" uniqKey="Chapurlat R" first="R. D." last="Chapurlat">R. D. Chapurlat</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Compston, J E" sort="Compston, J E" uniqKey="Compston J" first="J. E." last="Compston">J. E. Compston</name><affiliation wicri:level="4"><nlm:aff id="Aff5">School of Clinical Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Clinical Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C." last="Cooper">C. Cooper</name><affiliation wicri:level="1"><nlm:aff id="Aff6">MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff7">Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Musculoskeletal Sciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Delmas, P" sort="Delmas, P" uniqKey="Delmas P" first="P." last="Delmas">P. Delmas</name><affiliation wicri:level="3"><nlm:aff id="Aff4">Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Diez Perez, A" sort="Diez Perez, A" uniqKey="Diez Perez A" first="A." last="Díez-Pérez">A. Díez-Pérez</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Department of Medicine, Hospital del Mar-IMIM-Autonomous, University of Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Medicine, Hospital del Mar-IMIM-Autonomous, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Hooven, F H" sort="Hooven, F H" uniqKey="Hooven F" first="F. H." last="Hooven">F. H. Hooven</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Outcomes Research, UMASS Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Lacroix, A Z" sort="Lacroix, A Z" uniqKey="Lacroix A" first="A. Z." last="Lacroix">A. Z. Lacroix</name><affiliation wicri:level="2"><nlm:aff id="Aff11">Fred Hutchinson Cancer Research Center, Seattle, WA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Netelenbos, J C" sort="Netelenbos, J C" uniqKey="Netelenbos J" first="J. C." last="Netelenbos">J. C. Netelenbos</name><affiliation wicri:level="3"><nlm:aff id="Aff12">Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Pfeilschifter, J" sort="Pfeilschifter, J" uniqKey="Pfeilschifter J" first="J." last="Pfeilschifter">J. Pfeilschifter</name><affiliation wicri:level="1"><nlm:aff id="Aff13">Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Rossini, M" sort="Rossini, M" uniqKey="Rossini M" first="M." last="Rossini">M. Rossini</name><affiliation wicri:level="1"><nlm:aff id="Aff14">Department of Rheumatology, University of Verona, Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Rheumatology, University of Verona, Verona</wicri:regionArea><wicri:noRegion>Verona</wicri:noRegion></affiliation></author><author><name sortKey="Roux, C" sort="Roux, C" uniqKey="Roux C" first="C." last="Roux">C. Roux</name><affiliation wicri:level="3"><nlm:aff id="Aff15">Paris Descartes University, Cochin Hospital, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paris Descartes University, Cochin Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Saag, K G" sort="Saag, K G" uniqKey="Saag K" first="K. G." last="Saag">K. G. Saag</name><affiliation wicri:level="2"><nlm:aff id="Aff16">University of Alabama-Birmingham, Birmingham, AL USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>University of Alabama-Birmingham, Birmingham</wicri:cityArea></affiliation></author><author><name sortKey="Sambrook, P" sort="Sambrook, P" uniqKey="Sambrook P" first="P." last="Sambrook">P. Sambrook</name><affiliation wicri:level="2"><nlm:aff id="Aff17">University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, NSW Australia</nlm:aff><country>Australie</country><placeName><region type="state">Nouvelle-Galles du Sud</region></placeName><wicri:cityArea>University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney</wicri:cityArea></affiliation></author><author><name sortKey="Silverman, S" sort="Silverman, S" uniqKey="Silverman S" first="S." last="Silverman">S. Silverman</name><affiliation wicri:level="2"><nlm:aff id="Aff18">Department of Rheumatology, Cedars-Sinai/UCLA, Los Angeles, CA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Rheumatology, Cedars-Sinai/UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Watts, N B" sort="Watts, N B" uniqKey="Watts N" first="N. B." last="Watts">N. B. Watts</name><affiliation wicri:level="2"><nlm:aff id="Aff19">Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Wyman, A" sort="Wyman, A" uniqKey="Wyman A" first="A." last="Wyman">A. Wyman</name><affiliation wicri:level="2"><nlm:aff id="Aff9">Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Outcomes Research, UMASS Medical School, Worcester</wicri:cityArea></affiliation></author><author><name sortKey="Greenspan, S L" sort="Greenspan, S L" uniqKey="Greenspan S" first="S. L." last="Greenspan">S. L. Greenspan</name><affiliation wicri:level="2"><nlm:aff id="Aff10">University of Pittsburgh, Pittsburgh, PA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">Osteoporosis International</title><idno type="ISSN">0937-941X</idno><idno type="eISSN">1433-2965</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Summary</title><p>We compared self-perception of fracture risk with actual risk among 60,393 postmenopausal women aged ≥55 years, using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Most postmenopausal women with risk factors failed to appreciate their actual risk for fracture. Improved education about osteoporosis risk factors is needed.</p></sec><sec><title>Introduction</title><p>This study seeks to compare self-perception of fracture risk with actual risk among postmenopausal women using data from GLOW.</p></sec><sec><title>Methods</title><p>GLOW is an international, observational, cohort study involving 723 physician practices in 17 sites in ten countries in Europe, North America, and Australia. Participants included 60,393 women ≥55 years attended by their physician during the previous 24 months. The sample was enriched so that two thirds were ≥65 years. Baseline surveys were mailed October 2006 to February 2008. Main outcome measures were self-perception of fracture risk in women with elevated risk vs women of the same age and frequency of risk factors for fragility fracture.</p></sec><sec><title>Results</title><p>In the overall study population, 19% (10,951/58,434) of women rated their risk of fracture as a little/much higher than that of women of the same age; 46% (27,138/58,434) said it was similar; 35% (20,345/58,434) believed it to be a little/much lower. Among women whose actual risk was increased based on the presence of any one of seven risk factors for fracture, the proportion who recognized their increased risk ranged from 19% for smokers to 39% for current users of glucocorticoid medication. Only 33% (4,185/12,612) of those with ≥2 risk factors perceived themselves as being at higher risk. Among women reporting a diagnosis of osteopenia or osteoporosis, only 25% and 43%, respectively, thought their risk was increased.</p></sec><sec><title>Conclusion</title><p>In this international, observational study, most postmenopausal women with risk factors failed to appreciate their actual risk for fracture.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cranney, A" uniqKey="Cranney A">A Cranney</name></author><author><name sortKey="Guyatt, G" uniqKey="Guyatt G">G Guyatt</name></author><author><name sortKey="Griffith, L" uniqKey="Griffith L">L Griffith</name></author><author><name sortKey="Wells, G" uniqKey="Wells G">G Wells</name></author><author><name sortKey="Tugwell, P" uniqKey="Tugwell P">P Tugwell</name></author><author><name sortKey="Rosen, C" uniqKey="Rosen C">C Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sambrook, P" uniqKey="Sambrook P">P Sambrook</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elliot Gibson, V" uniqKey="Elliot Gibson V">V Elliot-Gibson</name></author><author><name sortKey="Bogoch, Er" uniqKey="Bogoch E">ER Bogoch</name></author><author><name sortKey="Jamal, Sa" uniqKey="Jamal S">SA Jamal</name></author><author><name sortKey="Beaton, De" uniqKey="Beaton D">DE Beaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giangregorio, L" uniqKey="Giangregorio L">L Giangregorio</name></author><author><name sortKey="Papaioannou, A" uniqKey="Papaioannou A">A Papaioannou</name></author><author><name sortKey="Cranney, A" uniqKey="Cranney A">A Cranney</name></author><author><name sortKey="Zytaruk, N" uniqKey="Zytaruk N">N Zytaruk</name></author><author><name sortKey="Adachi, Jd" uniqKey="Adachi J">JD 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sortKey="Thabane, L" uniqKey="Thabane L">L Thabane</name></author><author><name sortKey="Debeer, J" uniqKey="Debeer J">J DeBeer</name></author><author><name sortKey="Cranney, A" uniqKey="Cranney A">A Cranney</name></author><author><name sortKey="Dolovich, L" uniqKey="Dolovich L">L Dolovich</name></author><author><name sortKey="Adili, A" uniqKey="Adili A">A Adili</name></author><author><name sortKey="Adachi, Jd" uniqKey="Adachi J">JD Adachi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hooven, Fh" uniqKey="Hooven F">FH Hooven</name></author><author><name sortKey="Adachi, Jd" uniqKey="Adachi J">JD Adachi</name></author><author><name sortKey="Adami, S" uniqKey="Adami S">S Adami</name></author><author><name sortKey="Boonen, S" uniqKey="Boonen S">S Boonen</name></author><author><name sortKey="Compston, J" uniqKey="Compston J">J Compston</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Delmas, P" uniqKey="Delmas P">P Delmas</name></author><author><name sortKey="Diez Perez, A" uniqKey="Diez Perez A">A Diez-Perez</name></author><author><name sortKey="Gehlbach, S" uniqKey="Gehlbach S">S Gehlbach</name></author><author><name sortKey="Greenspan, Sl" uniqKey="Greenspan S">SL Greenspan</name></author><author><name sortKey="Lacroix, A" uniqKey="Lacroix A">A LaCroix</name></author><author><name sortKey="Lindsay, R" uniqKey="Lindsay R">R Lindsay</name></author><author><name sortKey="Netelenbos, Jc" uniqKey="Netelenbos J">JC Netelenbos</name></author><author><name sortKey="Pfeilschifter, J" uniqKey="Pfeilschifter J">J Pfeilschifter</name></author><author><name sortKey="Roux, C" uniqKey="Roux C">C Roux</name></author><author><name sortKey="Saag, Kg" uniqKey="Saag K">KG Saag</name></author><author><name sortKey="Sambrook, P" uniqKey="Sambrook P">P Sambrook</name></author><author><name sortKey="Silverman, S" uniqKey="Silverman S">S Silverman</name></author><author><name sortKey="Siris, E" uniqKey="Siris E">E Siris</name></author><author><name sortKey="Watts, Nb" uniqKey="Watts N">NB Watts</name></author><author><name sortKey="Anderson, Fa" uniqKey="Anderson F">FA Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haentjens, P" uniqKey="Haentjens P">P Haentjens</name></author><author><name sortKey="Johnell, O" uniqKey="Johnell O">O Johnell</name></author><author><name sortKey="Kanis, Ja" uniqKey="Kanis J">JA Kanis</name></author><author><name sortKey="Bouillon, R" uniqKey="Bouillon R">R Bouillon</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Lamraski, G" uniqKey="Lamraski G">G Lamraski</name></author><author><name sortKey="Vanderschueren, D" uniqKey="Vanderschueren D">D Vanderschueren</name></author><author><name sortKey="Kaufman, Jm" uniqKey="Kaufman J">JM Kaufman</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Osteoporos Int</journal-id><journal-title-group><journal-title>Osteoporosis International</journal-title></journal-title-group><issn pub-type="ppub">0937-941X</issn><issn pub-type="epub">1433-2965</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20358360</article-id><article-id pub-id-type="pmc">3017306</article-id><article-id pub-id-type="publisher-id">1211</article-id><article-id pub-id-type="doi">10.1007/s00198-010-1211-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Failure to perceive increased risk of fracture in women 55 years and older: the Global Longitudinal Study of Osteoporosis in Women (GLOW)</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Siris</surname><given-names>E. S.</given-names></name><address><phone>+1-212-3052529</phone><fax>+1-212-3056482</fax><email>es27@columbia.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gehlbach</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="Aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Adachi</surname><given-names>J. D.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Boonen</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chapurlat</surname><given-names>R. D.</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Compston</surname><given-names>J. E.</given-names></name><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Cooper</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="Aff6">6</xref><xref ref-type="aff" rid="Aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Delmas</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Díez-Pérez</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="Aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Hooven</surname><given-names>F. H.</given-names></name><xref ref-type="aff" rid="Aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>LaCroix</surname><given-names>A. Z.</given-names></name><xref ref-type="aff" rid="Aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Netelenbos</surname><given-names>J. C.</given-names></name><xref ref-type="aff" rid="Aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Pfeilschifter</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="Aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Rossini</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="Aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Roux</surname><given-names>C.</given-names></name><xref ref-type="aff" rid="Aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Saag</surname><given-names>K. G.</given-names></name><xref ref-type="aff" rid="Aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Sambrook</surname><given-names>P.</given-names></name><xref ref-type="aff" rid="Aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Silverman</surname><given-names>S.</given-names></name><xref ref-type="aff" rid="Aff18">18</xref></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>N. B.</given-names></name><xref ref-type="aff" rid="Aff19">19</xref></contrib><contrib contrib-type="author"><name><surname>Wyman</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="Aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Greenspan</surname><given-names>S. L.</given-names></name><xref ref-type="aff" rid="Aff10">10</xref></contrib><aff id="Aff1"><label>1</label>Department of Medicine, Columbia University Medical Center, 180 Fort Washington Avenue, Harkness Pavilion 9-964, New York, NY 10032 USA</aff><aff id="Aff2"><label>2</label>St. Joseph’s Hospital, McMaster University, Hamilton, ON Canada</aff><aff id="Aff3"><label>3</label>Leuven University Center for Metabolic Bone Diseases, Division of Geriatric Medicine, Katholieke Universiteit Leuven, Leuven, Belgium</aff><aff id="Aff4"><label>4</label>Division of Rheumatology, Hôpital E. Herriot, INSERM U831, Université de Lyon, Lyon, France</aff><aff id="Aff5"><label>5</label>School of Clinical Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK</aff><aff id="Aff6"><label>6</label>MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK</aff><aff id="Aff7"><label>7</label>Institute of Musculoskeletal Sciences, University of Oxford, Oxford, UK</aff><aff id="Aff8"><label>8</label>Department of Medicine, Hospital del Mar-IMIM-Autonomous, University of Barcelona, Barcelona, Spain</aff><aff id="Aff9"><label>9</label>Center for Outcomes Research, UMASS Medical School, Worcester, MA USA</aff><aff id="Aff10"><label>10</label>University of Pittsburgh, Pittsburgh, PA USA</aff><aff id="Aff11"><label>11</label>Fred Hutchinson Cancer Research Center, Seattle, WA USA</aff><aff id="Aff12"><label>12</label>Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="Aff13"><label>13</label>Department of Internal Medicine III, Alfried Krupp Krankenhaus, Essen, Germany</aff><aff id="Aff14"><label>14</label>Department of Rheumatology, University of Verona, Verona, Italy</aff><aff id="Aff15"><label>15</label>Paris Descartes University, Cochin Hospital, Paris, France</aff><aff id="Aff16"><label>16</label>University of Alabama-Birmingham, Birmingham, AL USA</aff><aff id="Aff17"><label>17</label>University of Sydney-Royal North Shore Hospital, St. Leonards, Sydney, NSW Australia</aff><aff id="Aff18"><label>18</label>Department of Rheumatology, Cedars-Sinai/UCLA, Los Angeles, CA USA</aff><aff id="Aff19"><label>19</label>Bone Health and Osteoporosis Center, University of Cincinnati, Cincinnati, OH USA</aff></contrib-group><pub-date pub-type="epub"><day>1</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>1</month><year>2011</year></pub-date><volume>22</volume><issue>1</issue><fpage>27</fpage><lpage>35</lpage><history><date date-type="received"><day>10</day><month>12</month><year>2009</year></date><date date-type="accepted"><day>2</day><month>2</month><year>2010</year></date></history><permissions><copyright-statement>© The Author(s) 2010</copyright-statement></permissions><abstract><sec><title>Summary</title><p>We compared self-perception of fracture risk with actual risk among 60,393 postmenopausal women aged ≥55 years, using data from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Most postmenopausal women with risk factors failed to appreciate their actual risk for fracture. Improved education about osteoporosis risk factors is needed.</p></sec><sec><title>Introduction</title><p>This study seeks to compare self-perception of fracture risk with actual risk among postmenopausal women using data from GLOW.</p></sec><sec><title>Methods</title><p>GLOW is an international, observational, cohort study involving 723 physician practices in 17 sites in ten countries in Europe, North America, and Australia. Participants included 60,393 women ≥55 years attended by their physician during the previous 24 months. The sample was enriched so that two thirds were ≥65 years. Baseline surveys were mailed October 2006 to February 2008. Main outcome measures were self-perception of fracture risk in women with elevated risk vs women of the same age and frequency of risk factors for fragility fracture.</p></sec><sec><title>Results</title><p>In the overall study population, 19% (10,951/58,434) of women rated their risk of fracture as a little/much higher than that of women of the same age; 46% (27,138/58,434) said it was similar; 35% (20,345/58,434) believed it to be a little/much lower. Among women whose actual risk was increased based on the presence of any one of seven risk factors for fracture, the proportion who recognized their increased risk ranged from 19% for smokers to 39% for current users of glucocorticoid medication. Only 33% (4,185/12,612) of those with ≥2 risk factors perceived themselves as being at higher risk. Among women reporting a diagnosis of osteopenia or osteoporosis, only 25% and 43%, respectively, thought their risk was increased.</p></sec><sec><title>Conclusion</title><p>In this international, observational study, most postmenopausal women with risk factors failed to appreciate their actual risk for fracture.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Osteoporosis</kwd><kwd>Postmenopausal</kwd><kwd>Risk factor</kwd><kwd>Women</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© International Osteoporosis Foundation and National Osteoporosis Foundation 2011</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Alabama</li><li>Angleterre</li><li>Angleterre de l'Est</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Catalogne</li><li>Hollande-Septentrionale</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Ontario</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Cambridge</li><li>Hamilton (Ontario)</li><li>Lyon</li><li>Oxford</li><li>Paris</li></settlement><orgName><li>Université McMaster</li><li>Université d'Oxford</li><li>Université de Cambridge</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Siris, E S" sort="Siris, E S" uniqKey="Siris E" first="E. S." last="Siris">E. S. Siris</name></region><name sortKey="Gehlbach, S" sort="Gehlbach, S" uniqKey="Gehlbach S" first="S." last="Gehlbach">S. Gehlbach</name><name sortKey="Greenspan, S L" sort="Greenspan, S L" uniqKey="Greenspan S" first="S. L." last="Greenspan">S. L. Greenspan</name><name sortKey="Hooven, F H" sort="Hooven, F H" uniqKey="Hooven F" first="F. H." last="Hooven">F. H. Hooven</name><name sortKey="Lacroix, A Z" sort="Lacroix, A Z" uniqKey="Lacroix A" first="A. Z." last="Lacroix">A. Z. Lacroix</name><name sortKey="Saag, K G" sort="Saag, K G" uniqKey="Saag K" first="K. G." last="Saag">K. G. Saag</name><name sortKey="Silverman, S" sort="Silverman, S" uniqKey="Silverman S" first="S." last="Silverman">S. Silverman</name><name sortKey="Watts, N B" sort="Watts, N B" uniqKey="Watts N" first="N. B." last="Watts">N. B. Watts</name><name sortKey="Wyman, A" sort="Wyman, A" uniqKey="Wyman A" first="A." last="Wyman">A. Wyman</name></country><country name="Canada"><region name="Ontario"><name sortKey="Adachi, J D" sort="Adachi, J D" uniqKey="Adachi J" first="J. D." last="Adachi">J. D. Adachi</name></region></country><country name="Belgique"><noRegion><name sortKey="Boonen, S" sort="Boonen, S" uniqKey="Boonen S" first="S." last="Boonen">S. Boonen</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Chapurlat, R D" sort="Chapurlat, R D" uniqKey="Chapurlat R" first="R. D." last="Chapurlat">R. D. Chapurlat</name></region><name sortKey="Delmas, P" sort="Delmas, P" uniqKey="Delmas P" first="P." last="Delmas">P. Delmas</name><name sortKey="Roux, C" sort="Roux, C" uniqKey="Roux C" first="C." last="Roux">C. Roux</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Compston, J E" sort="Compston, J E" uniqKey="Compston J" first="J. E." last="Compston">J. E. Compston</name></region><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C." last="Cooper">C. Cooper</name><name sortKey="Cooper, C" sort="Cooper, C" uniqKey="Cooper C" first="C." last="Cooper">C. Cooper</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Diez Perez, A" sort="Diez Perez, A" uniqKey="Diez Perez A" first="A." last="Díez-Pérez">A. Díez-Pérez</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Netelenbos, J C" sort="Netelenbos, J C" uniqKey="Netelenbos J" first="J. C." last="Netelenbos">J. C. Netelenbos</name></region></country><country name="Allemagne"><noRegion><name sortKey="Pfeilschifter, J" sort="Pfeilschifter, J" uniqKey="Pfeilschifter J" first="J." last="Pfeilschifter">J. Pfeilschifter</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Rossini, M" sort="Rossini, M" uniqKey="Rossini M" first="M." last="Rossini">M. Rossini</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Sambrook, P" sort="Sambrook, P" uniqKey="Sambrook P" first="P." last="Sambrook">P. Sambrook</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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