Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis
Identifieur interne : 001B29 ( Pmc/Checkpoint ); précédent : 001B28; suivant : 001B30Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis
Auteurs : Azeez Butali [États-Unis] ; Julian Little [Canada] ; Cécile Chevrier [France] ; Sylvian Cordier [France] ; Regine Steegers-Theunissen [Pays-Bas] ; Astanand Jugessur [Norvège, Australie] ; Bola Oladugba [Nigeria] ; Peter A. Mossey [Royaume-Uni]Source :
- Birth defects research. Part A, Clinical and molecular teratology [ 1542-0752 ] ; 2013.
Abstract
This study examines gene-environment interaction (GEI) between the
We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal
There was a reduced risk of CL(P) with maternal folic acid use (
This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.
Url:
DOI: 10.1002/bdra.23133
PubMed: 23670871
PubMed Central: 3745533
Affiliations:
- Australie, Canada, France, Nigeria, Norvège, Pays-Bas, Royaume-Uni, États-Unis
- Gueldre, Iowa, Région Bretagne
- Iowa City, Nimègue, Rennes
- Université de l'Iowa
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PMC:3745533Le document en format XML
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Mossey</name><affiliation wicri:level="1"><nlm:aff id="A9">Dundee Dental School and Hospital, University of Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dundee Dental School and Hospital, University of Dundee</wicri:regionArea><wicri:noRegion>University of Dundee</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23670871</idno><idno type="pmc">3745533</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745533</idno><idno type="RBID">PMC:3745533</idno><idno type="doi">10.1002/bdra.23133</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001E15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E15</idno><idno type="wicri:Area/Pmc/Curation">001C71</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C71</idno><idno type="wicri:Area/Pmc/Checkpoint">001B29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Folic Acid Supplementation Use and the <italic>MTHFR</italic> C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis</title><author><name sortKey="Butali, Azeez" sort="Butali, Azeez" uniqKey="Butali A" first="Azeez" last="Butali">Azeez Butali</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Pediatrics, University of Iowa, U.S.A</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Iowa</wicri:regionArea><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Epidemiology and Community Medicine, University of Ottawa, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Epidemiology and Community Medicine, University of Ottawa</wicri:regionArea><wicri:noRegion>University of Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Chevrier, Cecile" sort="Chevrier, Cecile" uniqKey="Chevrier C" first="Cécile" last="Chevrier">Cécile Chevrier</name><affiliation wicri:level="3"><nlm:aff id="A3">Institut National de la Santé et de Recherche Médicale, Rennes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de Recherche Médicale, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Cordier, Sylvian" sort="Cordier, Sylvian" uniqKey="Cordier S" first="Sylvian" last="Cordier">Sylvian Cordier</name><affiliation wicri:level="3"><nlm:aff id="A3">Institut National de la Santé et de Recherche Médicale, Rennes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de Recherche Médicale, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Steegers Theunissen, Regine" sort="Steegers Theunissen, Regine" uniqKey="Steegers Theunissen R" first="Regine" last="Steegers-Theunissen">Regine Steegers-Theunissen</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 DR Rotterdam</wicri:regionArea><wicri:noRegion>3000 DR Rotterdam</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A5">Department of Epidemiology, Radboud University Medical Center, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Radboud University Medical Center, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Jugessur, Astanand" sort="Jugessur, Astanand" uniqKey="Jugessur A" first="Astanand" last="Jugessur">Astanand Jugessur</name><affiliation wicri:level="1"><nlm:aff id="A6">Division of Epidemiology, Norwegian Institute of Public Health, N-0403 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Epidemiology, Norwegian Institute of Public Health, N-0403 Oslo</wicri:regionArea><wicri:noRegion>N-0403 Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A7">Craniofacial Research, Murdoch Childrens Research Institute, Royal Children's Hospital, 3052 Parkville, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Craniofacial Research, Murdoch Childrens Research Institute, Royal Children's Hospital, 3052 Parkville</wicri:regionArea><wicri:noRegion>3052 Parkville</wicri:noRegion></affiliation></author><author><name sortKey="Oladugba, Bola" sort="Oladugba, Bola" uniqKey="Oladugba B" first="Bola" last="Oladugba">Bola Oladugba</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Statistics, University of Nigeria, Nsukka, Nigeria</nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Statistics, University of Nigeria, Nsukka</wicri:regionArea><wicri:noRegion>Nsukka</wicri:noRegion></affiliation></author><author><name sortKey="Mossey, Peter A" sort="Mossey, Peter A" uniqKey="Mossey P" first="Peter A." last="Mossey">Peter A. Mossey</name><affiliation wicri:level="1"><nlm:aff id="A9">Dundee Dental School and Hospital, University of Dundee, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Dundee Dental School and Hospital, University of Dundee</wicri:regionArea><wicri:noRegion>University of Dundee</wicri:noRegion></affiliation></author></analytic><series><title level="j">Birth defects research. Part A, Clinical and molecular teratology</title><idno type="ISSN">1542-0752</idno><idno type="eISSN">1542-0760</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">This study examines gene-environment interaction (GEI) between the <italic>MTHFR</italic> C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analyticapproach on four studies that used similar methods.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal <italic>MTHFR</italic> C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non syndromic cleft palate (CP)] and control groups.</p></sec><sec id="S3"><title>Results</title><p id="P3">There was a reduced risk of CL(P) with maternal folic acid use (<italic>p</italic>=0.008; OR=0.70, 95% CI: 0.65–0.94) and with supplements containing folic acid (<italic>p</italic>=0.028, OR=0.80, 95% CI: 0.65–0.94). Maternal smoking increased the risk of both CL(P) (<italic>p</italic><10e−3; OR=1.62, 95% CI: 1.35–1.95) and CP (<italic>p</italic>=0.028; OR=1.38, 95% CI: 1.04–1.83). No significant risk was observed with either maternal or fetal <italic>MTHFR</italic> C677T genotypes.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101155107</journal-id><journal-id journal-id-type="pubmed-jr-id">30290</journal-id><journal-id journal-id-type="nlm-ta">Birth Defects Res A Clin Mol Teratol</journal-id><journal-id journal-id-type="iso-abbrev">Birth Defects Res. Part A Clin. Mol. Teratol.</journal-id><journal-title-group><journal-title>Birth defects research. Part A, Clinical and molecular teratology</journal-title></journal-title-group><issn pub-type="ppub">1542-0752</issn><issn pub-type="epub">1542-0760</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23670871</article-id><article-id pub-id-type="pmc">3745533</article-id><article-id pub-id-type="doi">10.1002/bdra.23133</article-id><article-id pub-id-type="manuscript">NIHMS464334</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Folic Acid Supplementation Use and the <italic>MTHFR</italic> C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Butali</surname><given-names>Azeez</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Little</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chevrier</surname><given-names>Cécile</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cordier</surname><given-names>Sylvian</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Steegers-Theunissen</surname><given-names>Regine</given-names></name><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Jugessur</surname><given-names>Astanand</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Oladugba</surname><given-names>Bola</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Mossey</surname><given-names>Peter A.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Pediatrics, University of Iowa, U.S.A</aff><aff id="A2"><label>2</label>Department of Epidemiology and Community Medicine, University of Ottawa, Canada</aff><aff id="A3"><label>3</label>Institut National de la Santé et de Recherche Médicale, Rennes, France</aff><aff id="A4"><label>4</label>Department of Obstetrics and Gynecology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands</aff><aff id="A5"><label>5</label>Department of Epidemiology, Radboud University Medical Center, Nijmegen, The Netherlands</aff><aff id="A6"><label>6</label>Division of Epidemiology, Norwegian Institute of Public Health, N-0403 Oslo, Norway</aff><aff id="A7"><label>7</label>Craniofacial Research, Murdoch Childrens Research Institute, Royal Children's Hospital, 3052 Parkville, Australia</aff><aff id="A8"><label>8</label>Department of Statistics, University of Nigeria, Nsukka, Nigeria</aff><aff id="A9"><label>9</label>Dundee Dental School and Hospital, University of Dundee, UK</aff><author-notes><corresp id="cor1">Corresponding Author: Azeez Butali, Department of Pediatrics, University of Iowa, 500 Newton Road, Iowa City, Iowa. 52242, <email>Azeez-butali@uiowa.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>4</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>13</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2014</year></pub-date><volume>97</volume><issue>8</issue><elocation-id>10.1002/bdra.23133</elocation-id><abstract><sec id="S1"><title>Background</title><p id="P1">This study examines gene-environment interaction (GEI) between the <italic>MTHFR</italic> C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). We used a pooled-analyticapproach on four studies that used similar methods.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We used logistic regression to analyse the pooled sample of 1149 isolated cases and 1161 controls. Fetal and maternal <italic>MTHFR</italic> C677T genotypes, and maternal periconceptional exposure to smoking, alcohol, vitamin containing folic acid and folic acid supplements were contrasted between the cleft types [non-syndromic clefts lip or without cleft palate (CL(P)) and non syndromic cleft palate (CP)] and control groups.</p></sec><sec id="S3"><title>Results</title><p id="P3">There was a reduced risk of CL(P) with maternal folic acid use (<italic>p</italic>=0.008; OR=0.70, 95% CI: 0.65–0.94) and with supplements containing folic acid (<italic>p</italic>=0.028, OR=0.80, 95% CI: 0.65–0.94). Maternal smoking increased the risk of both CL(P) (<italic>p</italic><10e−3; OR=1.62, 95% CI: 1.35–1.95) and CP (<italic>p</italic>=0.028; OR=1.38, 95% CI: 1.04–1.83). No significant risk was observed with either maternal or fetal <italic>MTHFR</italic> C677T genotypes.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">This individual paticipant data (IPD) meta-analysis affords greater statistical power and can help alleviate the problems associated with aggregate-level data-sharing. The result of this IPD meta-analysis is consistent with previous reports suggesting that folic acid and smoking influence OFC outcomes.</p></sec></abstract><kwd-group><kwd>Cleft lip and palate</kwd><kwd><italic>MTHFR</italic></kwd><kwd>Folic acid</kwd><kwd>Individual patient data</kwd><kwd>pooled-analysis</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>K99 DE022378 || DE</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Nigeria</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Gueldre</li><li>Iowa</li><li>Région Bretagne</li></region><settlement><li>Iowa City</li><li>Nimègue</li><li>Rennes</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Butali, Azeez" sort="Butali, Azeez" uniqKey="Butali A" first="Azeez" last="Butali">Azeez Butali</name></region></country><country name="Canada"><noRegion><name sortKey="Little, Julian" sort="Little, Julian" uniqKey="Little J" first="Julian" last="Little">Julian Little</name></noRegion></country><country name="France"><region name="Région Bretagne"><name sortKey="Chevrier, Cecile" sort="Chevrier, Cecile" uniqKey="Chevrier C" first="Cécile" last="Chevrier">Cécile Chevrier</name></region><name sortKey="Cordier, Sylvian" sort="Cordier, Sylvian" uniqKey="Cordier S" first="Sylvian" last="Cordier">Sylvian Cordier</name></country><country name="Pays-Bas"><noRegion><name sortKey="Steegers Theunissen, Regine" sort="Steegers Theunissen, Regine" uniqKey="Steegers Theunissen R" first="Regine" last="Steegers-Theunissen">Regine Steegers-Theunissen</name></noRegion><name sortKey="Steegers Theunissen, Regine" sort="Steegers Theunissen, Regine" uniqKey="Steegers Theunissen R" first="Regine" last="Steegers-Theunissen">Regine Steegers-Theunissen</name></country><country name="Norvège"><noRegion><name sortKey="Jugessur, Astanand" sort="Jugessur, Astanand" uniqKey="Jugessur A" first="Astanand" last="Jugessur">Astanand Jugessur</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Jugessur, Astanand" sort="Jugessur, Astanand" uniqKey="Jugessur A" first="Astanand" last="Jugessur">Astanand Jugessur</name></noRegion></country><country name="Nigeria"><noRegion><name sortKey="Oladugba, Bola" sort="Oladugba, Bola" uniqKey="Oladugba B" first="Bola" last="Oladugba">Bola Oladugba</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Mossey, Peter A" sort="Mossey, Peter A" uniqKey="Mossey P" first="Peter A." last="Mossey">Peter A. 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