The EF-Hand Ca2+ Binding Protein MICU Choreographs Mitochondrial Ca2+ Dynamics in Arabidopsis[OPEN]
Identifieur interne : 000C86 ( Pmc/Checkpoint ); précédent : 000C85; suivant : 000C87The EF-Hand Ca2+ Binding Protein MICU Choreographs Mitochondrial Ca2+ Dynamics in Arabidopsis[OPEN]
Auteurs : Stephan Wagner [Allemagne] ; Smrutisanjita Behera [Italie] ; Sara De Bortoli [Italie] ; David C. Logan [France] ; Philippe Fuchs [Allemagne] ; Luca Carraretto [Italie] ; Enrico Teardo [Italie] ; Laura Cendron [Italie] ; Thomas Nietzel [Allemagne] ; Magdalena Fü L [Allemagne] ; Fabrizio G. Doccula [Italie] ; Lorella Navazio [Italie] ; Mark D. Fricker [Royaume-Uni] ; Olivier Van Aken [Australie] ; Iris Finkemeier [Allemagne] ; Andreas J. Meyer [Allemagne] ; Ildik Szab [Italie] ; Alex Costa [Italie] ; Markus Schwarzl Nder [Allemagne]Source :
- The Plant Cell [ 1040-4651 ] ; 2015.
Abstract
The mitochondrial Ca2+ uptake protein At-MICU shapes mitochondrial Ca2+ dynamics, providing molecular in vivo evidence for the existence and function of a mitochondrial uniporter complex in plants.
Url:
DOI: 10.1105/tpc.15.00509
PubMed: 26530087
PubMed Central: 4682298
Affiliations:
- Allemagne, Australie, France, Italie, Royaume-Uni
- Angleterre, District de Cologne, District de Münster, Lombardie, Oxfordshire, Pays de la Loire, Rhénanie-du-Nord-Westphalie
- Angers, Bonn, Cologne, Milan, Münster, Oxford
- Université d'Angers, Université d'Oxford
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Fricker</name><affiliation wicri:level="4"><nlm:aff id="aff6">Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Plant Sciences, University of Oxford, Oxford OX1 3RB</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Van Aken, Olivier" sort="Van Aken, Olivier" uniqKey="Van Aken O" first="Olivier" last="Van Aken">Olivier Van Aken</name><affiliation wicri:level="1"><nlm:aff id="aff7">ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA 6009</wicri:regionArea><wicri:noRegion>WA 6009</wicri:noRegion></affiliation></author><author><name sortKey="Finkemeier, Iris" sort="Finkemeier, Iris" uniqKey="Finkemeier I" first="Iris" last="Finkemeier">Iris Finkemeier</name><affiliation wicri:level="3"><nlm:aff id="aff5">Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Institute for Plant Biology and Biotechnology, University of Münster, 48149 Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Plant Biology and Biotechnology, University of Münster, 48149 Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Meyer, Andreas J" sort="Meyer, Andreas J" uniqKey="Meyer A" first="Andreas J." last="Meyer">Andreas J. Meyer</name><affiliation wicri:level="3"><nlm:aff id="aff9">Department Chemical Signalling, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Chemical Signalling, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Szab, Ildik" sort="Szab, Ildik" uniqKey="Szab I" first="Ildik" last="Szab">Ildik Szab</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Alex" sort="Costa, Alex" uniqKey="Costa A" first="Alex" last="Costa">Alex Costa</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biosciences, University of Milan, 20133 Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biosciences, University of Milan, 20133 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10">Institute of Biophysics, Consiglio Nazionale delle Ricerche, 20133 Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biophysics, Consiglio Nazionale delle Ricerche, 20133 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Schwarzl Nder, Markus" sort="Schwarzl Nder, Markus" uniqKey="Schwarzl Nder M" first="Markus" last="Schwarzl Nder">Markus Schwarzl Nder</name><affiliation wicri:level="3"><nlm:aff id="aff1">Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26530087</idno><idno type="pmc">4682298</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682298</idno><idno type="RBID">PMC:4682298</idno><idno type="doi">10.1105/tpc.15.00509</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000217</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000217</idno><idno type="wicri:Area/Pmc/Curation">000217</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000217</idno><idno type="wicri:Area/Pmc/Checkpoint">000C86</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C86</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The EF-Hand Ca<sup>2+</sup> Binding Protein MICU Choreographs Mitochondrial Ca<sup>2+</sup> Dynamics in Arabidopsis<xref ref-type="fn" rid="fn1"><sup>[OPEN]</sup></xref></title><author><name sortKey="Wagner, Stephan" sort="Wagner, Stephan" uniqKey="Wagner S" first="Stephan" last="Wagner">Stephan Wagner</name><affiliation wicri:level="3"><nlm:aff id="aff1">Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Behera, Smrutisanjita" sort="Behera, Smrutisanjita" uniqKey="Behera S" first="Smrutisanjita" last="Behera">Smrutisanjita Behera</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biosciences, University of Milan, 20133 Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biosciences, University of Milan, 20133 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="De Bortoli, Sara" sort="De Bortoli, Sara" uniqKey="De Bortoli S" first="Sara" last="De Bortoli">Sara De Bortoli</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Logan, David C" sort="Logan, David C" uniqKey="Logan D" first="David C." last="Logan">David C. Logan</name><affiliation wicri:level="4"><nlm:aff id="aff4">Université d'Angers, INRA, Agrocampus Ouest, UMR 1345 Institut de Recherche en Horticulture et Semences, F-49045 Angers, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université d'Angers, INRA, Agrocampus Ouest, UMR 1345 Institut de Recherche en Horticulture et Semences, F-49045 Angers</wicri:regionArea><wicri:noRegion>49045 Angers</wicri:noRegion><orgName type="university">Université d'Angers</orgName><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Fuchs, Philippe" sort="Fuchs, Philippe" uniqKey="Fuchs P" first="Philippe" last="Fuchs">Philippe Fuchs</name><affiliation wicri:level="3"><nlm:aff id="aff1">Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Carraretto, Luca" sort="Carraretto, Luca" uniqKey="Carraretto L" first="Luca" last="Carraretto">Luca Carraretto</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Teardo, Enrico" sort="Teardo, Enrico" uniqKey="Teardo E" first="Enrico" last="Teardo">Enrico Teardo</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Cendron, Laura" sort="Cendron, Laura" uniqKey="Cendron L" first="Laura" last="Cendron">Laura Cendron</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Nietzel, Thomas" sort="Nietzel, Thomas" uniqKey="Nietzel T" first="Thomas" last="Nietzel">Thomas Nietzel</name><affiliation wicri:level="3"><nlm:aff id="aff1">Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Fu L, Magdalena" sort="Fu L, Magdalena" uniqKey="Fu L M" first="Magdalena" last="Fü L">Magdalena Fü L</name><affiliation wicri:level="3"><nlm:aff id="aff5">Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Doccula, Fabrizio G" sort="Doccula, Fabrizio G" uniqKey="Doccula F" first="Fabrizio G." last="Doccula">Fabrizio G. Doccula</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biosciences, University of Milan, 20133 Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biosciences, University of Milan, 20133 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Navazio, Lorella" sort="Navazio, Lorella" uniqKey="Navazio L" first="Lorella" last="Navazio">Lorella Navazio</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Fricker, Mark D" sort="Fricker, Mark D" uniqKey="Fricker M" first="Mark D." last="Fricker">Mark D. Fricker</name><affiliation wicri:level="4"><nlm:aff id="aff6">Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Plant Sciences, University of Oxford, Oxford OX1 3RB</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Van Aken, Olivier" sort="Van Aken, Olivier" uniqKey="Van Aken O" first="Olivier" last="Van Aken">Olivier Van Aken</name><affiliation wicri:level="1"><nlm:aff id="aff7">ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA 6009, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA 6009</wicri:regionArea><wicri:noRegion>WA 6009</wicri:noRegion></affiliation></author><author><name sortKey="Finkemeier, Iris" sort="Finkemeier, Iris" uniqKey="Finkemeier I" first="Iris" last="Finkemeier">Iris Finkemeier</name><affiliation wicri:level="3"><nlm:aff id="aff5">Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff8">Institute for Plant Biology and Biotechnology, University of Münster, 48149 Münster, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Plant Biology and Biotechnology, University of Münster, 48149 Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Meyer, Andreas J" sort="Meyer, Andreas J" uniqKey="Meyer A" first="Andreas J." last="Meyer">Andreas J. Meyer</name><affiliation wicri:level="3"><nlm:aff id="aff9">Department Chemical Signalling, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Chemical Signalling, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Szab, Ildik" sort="Szab, Ildik" uniqKey="Szab I" first="Ildik" last="Szab">Ildik Szab</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Biology, University of Padova, 35121 Padova, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Padova, 35121 Padova</wicri:regionArea><wicri:noRegion>35121 Padova</wicri:noRegion></affiliation></author><author><name sortKey="Costa, Alex" sort="Costa, Alex" uniqKey="Costa A" first="Alex" last="Costa">Alex Costa</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biosciences, University of Milan, 20133 Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biosciences, University of Milan, 20133 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10">Institute of Biophysics, Consiglio Nazionale delle Ricerche, 20133 Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biophysics, Consiglio Nazionale delle Ricerche, 20133 Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Schwarzl Nder, Markus" sort="Schwarzl Nder, Markus" uniqKey="Schwarzl Nder M" first="Markus" last="Schwarzl Nder">Markus Schwarzl Nder</name><affiliation wicri:level="3"><nlm:aff id="aff1">Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author></analytic><series><title level="j">The Plant Cell</title><idno type="ISSN">1040-4651</idno><idno type="eISSN">1532-298X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The mitochondrial Ca<sup>2+</sup> uptake protein At-MICU shapes mitochondrial Ca<sup>2+</sup> dynamics, providing molecular in vivo evidence for the existence and function of a mitochondrial uniporter complex in plants.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Cell</journal-id><journal-id journal-id-type="iso-abbrev">Plant Cell</journal-id><journal-id journal-id-type="hwp">plantcell</journal-id><journal-id journal-id-type="publisher-id">aspb</journal-id><journal-title-group><journal-title>The Plant Cell</journal-title></journal-title-group><issn pub-type="ppub">1040-4651</issn><issn pub-type="epub">1532-298X</issn><publisher><publisher-name>American Society of Plant Biologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26530087</article-id><article-id pub-id-type="pmc">4682298</article-id><article-id pub-id-type="publisher-id">TPC201500509RAR2</article-id><article-id pub-id-type="doi">10.1105/tpc.15.00509</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group></article-categories><title-group><article-title>The EF-Hand Ca<sup>2+</sup> Binding Protein MICU Choreographs Mitochondrial Ca<sup>2+</sup> Dynamics in Arabidopsis<xref ref-type="fn" rid="fn1"><sup>[OPEN]</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-5369-7911</contrib-id><name><surname>Wagner</surname><given-names>Stephan</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8749-6130</contrib-id><name><surname>Behera</surname><given-names>Smrutisanjita</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-3797-6966</contrib-id><name><surname>De Bortoli</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-8980-240X</contrib-id><name><surname>Logan</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-6379-853X</contrib-id><name><surname>Fuchs</surname><given-names>Philippe</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Carraretto</surname><given-names>Luca</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Teardo</surname><given-names>Enrico</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cendron</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-1934-1732</contrib-id><name><surname>Nietzel</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Füßl</surname><given-names>Magdalena</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author"><name><surname>Doccula</surname><given-names>Fabrizio G.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-5640-108X</contrib-id><name><surname>Navazio</surname><given-names>Lorella</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-8942-6897</contrib-id><name><surname>Fricker</surname><given-names>Mark D.</given-names></name><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-4024-968X</contrib-id><name><surname>Van Aken</surname><given-names>Olivier</given-names></name><xref ref-type="aff" rid="aff7"><sup>g</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-8972-4026</contrib-id><name><surname>Finkemeier</surname><given-names>Iris</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref><xref ref-type="aff" rid="aff8"><sup>h</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8144-4364</contrib-id><name><surname>Meyer</surname><given-names>Andreas J.</given-names></name><xref ref-type="aff" rid="aff9"><sup>i</sup></xref></contrib><contrib contrib-type="author"><name><surname>Szabò</surname><given-names>Ildikò</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2628-1176</contrib-id><name><surname>Costa</surname><given-names>Alex</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref ref-type="aff" rid="aff10"><sup>j</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-0796-8308</contrib-id><name><surname>Schwarzländer</surname><given-names>Markus</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>1</sup></xref></contrib><aff id="aff1"><label>a</label>Plant Energy Biology Lab, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</aff><aff id="aff2"><label>b</label>Department of Biosciences, University of Milan, 20133 Milan, Italy</aff><aff id="aff3"><label>c</label>Department of Biology, University of Padova, 35121 Padova, Italy</aff><aff id="aff4"><label>d</label>Université d'Angers, INRA, Agrocampus Ouest, UMR 1345 Institut de Recherche en Horticulture et Semences, F-49045 Angers, France</aff><aff id="aff5"><label>e</label>Plant Proteomics Group, Max-Planck-Institute for Plant Breeding Research, 50829 Cologne, Germany</aff><aff id="aff6"><label>f</label>Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom</aff><aff id="aff7"><label>g</label>ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA 6009, Australia</aff><aff id="aff8"><label>h</label>Institute for Plant Biology and Biotechnology, University of Münster, 48149 Münster, Germany</aff><aff id="aff9"><label>i</label>Department Chemical Signalling, Institute of Crop Science and Resource Conservation, University of Bonn, 53113 Bonn, Germany</aff><aff id="aff10"><label>j</label>Institute of Biophysics, Consiglio Nazionale delle Ricerche, 20133 Milan, Italy</aff></contrib-group><author-notes><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantcell.org/cgi/doi/10.1105/tpc.15.00509">www.plantcell.org/cgi/doi/10.1105/tpc.15.00509</ext-link></p></fn><corresp id="cor1"><label>1</label>Address correspondence to <email>markus.schwarzlander@uni-bonn.de</email>.</corresp><fn id="afn1"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantcell.org">www.plantcell.org</ext-link>) is: Markus Schwarzländer (<email>markus.schwarzlander@uni-bonn.de</email>).</p></fn></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>3</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>11</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>27</volume><issue>11</issue><fpage>3190</fpage><lpage>3212</lpage><history><date date-type="received"><day>10</day><month>6</month><year>2015</year></date><date date-type="rev-recd"><day>25</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 American Society of Plant Biologists. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri xlink:role="icon" xlink:href="PC_TPC201500509RAR2_ic1.gif"></self-uri><abstract abstract-type="precis"><p>The mitochondrial Ca<sup>2+</sup> uptake protein At-MICU shapes mitochondrial Ca<sup>2+</sup> dynamics, providing molecular in vivo evidence for the existence and function of a mitochondrial uniporter complex in plants.</p></abstract><abstract><p>Plant organelle function must constantly adjust to environmental conditions, which requires dynamic coordination. Ca<sup>2+</sup> signaling may play a central role in this process. Free Ca<sup>2+</sup> dynamics are tightly regulated and differ markedly between the cytosol, plastid stroma, and mitochondrial matrix. The mechanistic basis of compartment-specific Ca<sup>2+</sup> dynamics is poorly understood. Here, we studied the function of At-MICU, an EF-hand protein of <italic>Arabidopsis thaliana</italic> with homology to constituents of the mitochondrial Ca<sup>2+</sup> uniporter machinery in mammals. MICU binds Ca<sup>2+</sup> and localizes to the mitochondria in Arabidopsis. In vivo imaging of roots expressing a genetically encoded Ca<sup>2+</sup> sensor in the mitochondrial matrix revealed that lack of MICU increased resting concentrations of free Ca<sup>2+</sup> in the matrix. Furthermore, Ca<sup>2+</sup> elevations triggered by auxin and extracellular ATP occurred more rapidly and reached higher maximal concentrations in the mitochondria of <italic>micu</italic> mutants, whereas cytosolic Ca<sup>2+</sup> signatures remained unchanged. These findings support the idea that a conserved uniporter system, with composition and regulation distinct from the mammalian machinery, mediates mitochondrial Ca<sup>2+</sup> uptake in plants under in vivo conditions. They further suggest that MICU acts as a throttle that controls Ca<sup>2+</sup> uptake by moderating influx, thereby shaping Ca<sup>2+</sup> signatures in the matrix and preserving mitochondrial homeostasis. Our results open the door to genetic dissection of mitochondrial Ca<sup>2+</sup> signaling in plants.</p></abstract><counts><page-count count="23"></page-count></counts><custom-meta-group><custom-meta><meta-name> DJS Export </meta-name><meta-value>v1</meta-value></custom-meta></custom-meta-group></article-meta><notes><glossary><title>Glossary</title><def-list><def-item><term id="term1">MCUC</term><def id="def1"><p>mitochondrial Ca<sup>2+</sup> uniporter complex</p></def></def-item><def-item><term id="term2">IMM</term><def id="def2"><p>inner mitochondrial membrane</p></def></def-item><def-item><term id="term3">IMS</term><def id="def3"><p>intermembrane space</p></def></def-item><def-item><term id="term4">YC3.6</term><def id="def4"><p>Yellow Cameleon 3.6</p></def></def-item><def-item><term id="term5">FRET</term><def id="def5"><p>Förster resonance energy transfer</p></def></def-item><def-item><term id="term6">ROI</term><def id="def6"><p>region of interest</p></def></def-item><def-item><term id="term7">TMRM</term><def id="def7"><p>tetramethyl rhodamine methyl ester</p></def></def-item><def-item><term id="term8">NAA</term><def id="def8"><p>1-naphthaleneacetic acid</p></def></def-item><def-item><term id="term9">eATP</term><def id="def9"><p>extracellular ATP</p></def></def-item><def-item><term id="term10">OCR</term><def id="def10"><p>oxygen consumption rate</p></def></def-item><def-item><term id="term11">MS</term><def id="def11"><p>Murashige and Skoog</p></def></def-item></def-list></glossary></notes></front></pmc><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Cologne</li><li>District de Münster</li><li>Lombardie</li><li>Oxfordshire</li><li>Pays de la Loire</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Angers</li><li>Bonn</li><li>Cologne</li><li>Milan</li><li>Münster</li><li>Oxford</li></settlement><orgName><li>Université d'Angers</li><li>Université d'Oxford</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Wagner, Stephan" sort="Wagner, Stephan" uniqKey="Wagner S" first="Stephan" last="Wagner">Stephan Wagner</name></region><name sortKey="Finkemeier, Iris" sort="Finkemeier, Iris" uniqKey="Finkemeier I" first="Iris" last="Finkemeier">Iris Finkemeier</name><name sortKey="Finkemeier, Iris" sort="Finkemeier, Iris" uniqKey="Finkemeier I" first="Iris" last="Finkemeier">Iris Finkemeier</name><name sortKey="Fu L, Magdalena" sort="Fu L, Magdalena" uniqKey="Fu L M" first="Magdalena" last="Fü L">Magdalena Fü L</name><name sortKey="Fuchs, Philippe" sort="Fuchs, Philippe" uniqKey="Fuchs P" first="Philippe" last="Fuchs">Philippe Fuchs</name><name sortKey="Meyer, Andreas J" sort="Meyer, Andreas J" uniqKey="Meyer A" first="Andreas J." last="Meyer">Andreas J. Meyer</name><name sortKey="Nietzel, Thomas" sort="Nietzel, Thomas" uniqKey="Nietzel T" first="Thomas" last="Nietzel">Thomas Nietzel</name><name sortKey="Schwarzl Nder, Markus" sort="Schwarzl Nder, Markus" uniqKey="Schwarzl Nder M" first="Markus" last="Schwarzl Nder">Markus Schwarzl Nder</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Behera, Smrutisanjita" sort="Behera, Smrutisanjita" uniqKey="Behera S" first="Smrutisanjita" last="Behera">Smrutisanjita Behera</name></region><name sortKey="Carraretto, Luca" sort="Carraretto, Luca" uniqKey="Carraretto L" first="Luca" last="Carraretto">Luca Carraretto</name><name sortKey="Cendron, Laura" sort="Cendron, Laura" uniqKey="Cendron L" first="Laura" last="Cendron">Laura Cendron</name><name sortKey="Costa, Alex" sort="Costa, Alex" uniqKey="Costa A" first="Alex" last="Costa">Alex Costa</name><name sortKey="Costa, Alex" sort="Costa, Alex" uniqKey="Costa A" first="Alex" last="Costa">Alex Costa</name><name sortKey="De Bortoli, Sara" sort="De Bortoli, Sara" uniqKey="De Bortoli S" first="Sara" last="De Bortoli">Sara De Bortoli</name><name sortKey="Doccula, Fabrizio G" sort="Doccula, Fabrizio G" uniqKey="Doccula F" first="Fabrizio G." last="Doccula">Fabrizio G. Doccula</name><name sortKey="Navazio, Lorella" sort="Navazio, Lorella" uniqKey="Navazio L" first="Lorella" last="Navazio">Lorella Navazio</name><name sortKey="Szab, Ildik" sort="Szab, Ildik" uniqKey="Szab I" first="Ildik" last="Szab">Ildik Szab</name><name sortKey="Teardo, Enrico" sort="Teardo, Enrico" uniqKey="Teardo E" first="Enrico" last="Teardo">Enrico Teardo</name></country><country name="France"><region name="Pays de la Loire"><name sortKey="Logan, David C" sort="Logan, David C" uniqKey="Logan D" first="David C." last="Logan">David C. Logan</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fricker, Mark D" sort="Fricker, Mark D" uniqKey="Fricker M" first="Mark D." last="Fricker">Mark D. Fricker</name></region></country><country name="Australie"><noRegion><name sortKey="Van Aken, Olivier" sort="Van Aken, Olivier" uniqKey="Van Aken O" first="Olivier" last="Van Aken">Olivier Van Aken</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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