Identification of shared risk loci and pathways for bipolar disorder and schizophrenia
Identifieur interne : 000257 ( Pmc/Checkpoint ); précédent : 000256; suivant : 000258Identification of shared risk loci and pathways for bipolar disorder and schizophrenia
Auteurs : Andreas J. Forstner [Allemagne, Suisse] ; Julian Hecker [Allemagne] ; Andrea Hofmann [Allemagne] ; Anna Maaser [Allemagne] ; Céline S. Reinbold [Suisse] ; Thomas W. Mühleisen [Allemagne, Suisse] ; Markus Leber [Allemagne] ; Jana Strohmaier [Allemagne] ; Franziska Degenhardt [Allemagne] ; Jens Treutlein [Allemagne] ; Manuel Mattheisen [Allemagne, Danemark] ; Johannes Schumacher [Allemagne] ; Fabian Streit [Allemagne] ; Sandra Meier [Allemagne, Danemark] ; Stefan Herms [Allemagne, Suisse] ; Per Hoffmann [Allemagne, Suisse] ; André Lacour [Allemagne] ; Stephanie H. Witt [Allemagne] ; Andreas Reif [Allemagne] ; Bertram Müller-Myhsok [Allemagne, Royaume-Uni] ; Susanne Lucae [Allemagne] ; Wolfgang Maier [Allemagne] ; Markus Schwarz [Allemagne] ; Helmut Vedder [Allemagne] ; Jutta Kammerer-Ciernioch [Allemagne] ; Andrea Pfennig [Allemagne] ; Michael Bauer [Allemagne] ; Martin Hautzinger [Allemagne] ; Susanne Moebus [Allemagne] ; Lorena M. Schenk [Allemagne] ; Sascha B. Fischer [Suisse] ; Sugirthan Sivalingam [Allemagne] ; Piotr M. Czerski [Pologne] ; Joanna Hauser [Pologne] ; Jolanta Lissowska [Pologne] ; Neonila Szeszenia-Dabrowska [Pologne] ; Paul Brennan [France] ; James D. Mckay [France] ; Adam Wright [Australie] ; Philip B. Mitchell [Australie] ; Janice M. Fullerton [Australie] ; Peter R. Schofield [Australie] ; Grant W. Montgomery [Australie] ; Sarah E. Medland [Australie] ; Scott D. Gordon [Australie] ; Nicholas G. Martin [Australie] ; Valery Krasnov [Russie] ; Alexander Chuchalin [Russie] ; Gulja Babadjanova [Russie] ; Galina Pantelejeva [Russie] ; Lilia I. Abramova [Russie] ; Alexander S. Tiganov [Russie] ; Alexey Polonikov [Russie] ; Elza Khusnutdinova [Russie] ; Martin Alda [Canada, République tchèque] ; Cristiana Cruceanu [Canada] ; Guy A. Rouleau [Canada] ; Gustavo Turecki [Canada] ; Catherine Laprise [Canada] ; Fabio Rivas [Espagne] ; Fermin Mayoral [Espagne] ; Manolis Kogevinas [Espagne] ; Maria Grigoroiu-Serbanescu [Roumanie] ; Tim Becker [Allemagne] ; Thomas G. Schulze [Allemagne] ; Marcella Rietschel [Allemagne] ; Sven Cichon [Allemagne, Suisse] ; Heide Fier [Allemagne] ; Markus M. Nöthen [Allemagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (
Url:
DOI: 10.1371/journal.pone.0171595
PubMed: 28166306
PubMed Central: 5293228
Affiliations:
- Allemagne, Australie, Canada, Danemark, Espagne, France, Pologne, Roumanie, Royaume-Uni, Russie, République tchèque, Suisse
- Auvergne-Rhône-Alpes, Bade-Wurtemberg, Bavière, Catalogne, District de Cologne, District de Darmstadt, District de Dresde, District de Haute-Bavière, District de Karlsruhe, District de Tübingen, District fédéral central, Hesse (Land), Nouvelle-Galles du Sud, Québec, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Saxe (Land)
- Barcelone, Bonn, Dresde, Francfort-sur-le-Main, Lyon, Mannheim, Montréal, Moscou, Munich, Sydney, Tübingen
- Université McGill
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<author><name sortKey="Treutlein, Jens" sort="Treutlein, Jens" uniqKey="Treutlein J" first="Jens" last="Treutlein">Jens Treutlein</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name>
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<author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name>
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<author><name sortKey="Meier, Sandra" sort="Meier, Sandra" uniqKey="Meier S" first="Sandra" last="Meier">Sandra Meier</name>
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<author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
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</nlm:aff>
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</nlm:aff>
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<author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacour, Andre" sort="Lacour, Andre" uniqKey="Lacour A" first="André" last="Lacour">André Lacour</name>
<affiliation wicri:level="3"><nlm:aff id="aff014"><addr-line>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H." last="Witt">Stephanie H. Witt</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name>
<affiliation wicri:level="3"><nlm:aff id="aff015"><addr-line>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<affiliation wicri:level="3"><nlm:aff id="aff016"><addr-line>Max Planck Institute of Psychiatry, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff017"><addr-line>Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich Cluster for Systems Neurology (SyNergy), Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff018"><addr-line>University of Liverpool, Institute of Translational Medicine, Liverpool, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Liverpool, Institute of Translational Medicine, Liverpool</wicri:regionArea>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name>
<affiliation wicri:level="3"><nlm:aff id="aff016"><addr-line>Max Planck Institute of Psychiatry, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="3"><nlm:aff id="aff019"><addr-line>Department of Psychiatry, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Psychiatric Center Nordbaden, Wiesloch, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Psychiatric Center Nordbaden, Wiesloch</wicri:regionArea>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Psychiatric Center Nordbaden, Wiesloch, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Psychiatric Center Nordbaden, Wiesloch</wicri:regionArea>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name>
<affiliation wicri:level="1"><nlm:aff id="aff021"><addr-line>Center of Psychiatry Weinsberg, Weinsberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Psychiatry Weinsberg, Weinsberg</wicri:regionArea>
<wicri:noRegion>Weinsberg</wicri:noRegion>
<wicri:noRegion>Weinsberg</wicri:noRegion>
<wicri:noRegion>Weinsberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name>
<affiliation wicri:level="3"><nlm:aff id="aff023"><addr-line>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schenk, Lorena M" sort="Schenk, Lorena M" uniqKey="Schenk L" first="Lorena M." last="Schenk">Lorena M. Schenk</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fischer, Sascha B" sort="Fischer, Sascha B" uniqKey="Fischer S" first="Sascha B." last="Fischer">Sascha B. Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sivalingam, Sugirthan" sort="Sivalingam, Sugirthan" uniqKey="Sivalingam S" first="Sugirthan" last="Sivalingam">Sugirthan Sivalingam</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M." last="Czerski">Piotr M. Czerski</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="3"><nlm:aff id="aff028"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name>
<affiliation wicri:level="3"><nlm:aff id="aff029"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>School of Psychiatry, University of New South Wales, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff031"><addr-line>Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>School of Psychiatry, University of New South Wales, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff031"><addr-line>Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M." last="Fullerton">Janice M. Fullerton</name>
<affiliation wicri:level="3"><nlm:aff id="aff032"><addr-line>Neuroscience Research Australia, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
<affiliation wicri:level="3"><nlm:aff id="aff032"><addr-line>Neuroscience Research Australia, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name>
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<country xml:lang="fr">Australie</country>
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<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
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<country xml:lang="fr">Australie</country>
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</author>
<author><name sortKey="Krasnov, Valery" sort="Krasnov, Valery" uniqKey="Krasnov V" first="Valery" last="Krasnov">Valery Krasnov</name>
<affiliation wicri:level="3"><nlm:aff id="aff035"><addr-line>Moscow Research Institute of Psychiatry, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Moscow Research Institute of Psychiatry, Moscow</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name>
<affiliation wicri:level="3"><nlm:aff id="aff036"><addr-line>Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name>
<affiliation wicri:level="3"><nlm:aff id="aff036"><addr-line>Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name>
<affiliation wicri:level="3"><nlm:aff id="aff037"><addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I." last="Abramova">Lilia I. Abramova</name>
<affiliation wicri:level="3"><nlm:aff id="aff037"><addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S." last="Tiganov">Alexander S. Tiganov</name>
<affiliation wicri:level="3"><nlm:aff id="aff037"><addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Polonikov, Alexey" sort="Polonikov, Alexey" uniqKey="Polonikov A" first="Alexey" last="Polonikov">Alexey Polonikov</name>
<affiliation wicri:level="1"><nlm:aff id="aff038"><addr-line>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk</wicri:regionArea>
<wicri:noRegion>Kursk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff039"><addr-line>Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk</wicri:regionArea>
<wicri:noRegion>Kursk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name>
<affiliation wicri:level="1"><nlm:aff id="aff040"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea>
<wicri:noRegion>Ufa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff041"><addr-line>Department of Genetics and Fundamental Medicine of Bashkir State University, Ufa, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Genetics and Fundamental Medicine of Bashkir State University, Ufa</wicri:regionArea>
<wicri:noRegion>Ufa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name>
<affiliation wicri:level="1"><nlm:aff id="aff042"><addr-line>Department of Psychiatry, Dalhousie University, Halifax, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff043"><addr-line>National Institute of Mental Health, Klecany, Czech Republic</addr-line>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Mental Health, Klecany</wicri:regionArea>
<wicri:noRegion>Klecany</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name>
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</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff045"><addr-line>Department of Human Genetics, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Human Genetics, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff046"><addr-line>McGill Group for Suicide Studies & Douglas Research Institute, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill Group for Suicide Studies & Douglas Research Institute, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A." last="Rouleau">Guy A. Rouleau</name>
<affiliation wicri:level="4"><nlm:aff id="aff044"><addr-line>Montreal Neurological Institute, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
<affiliation wicri:level="4"><nlm:aff id="aff045"><addr-line>Department of Human Genetics, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Human Genetics, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff046"><addr-line>McGill Group for Suicide Studies & Douglas Research Institute, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill Group for Suicide Studies & Douglas Research Institute, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff047"><addr-line>Department of Psychiatry, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name>
<affiliation wicri:level="1"><nlm:aff id="aff048"><addr-line>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name>
<affiliation wicri:level="1"><nlm:aff id="aff049"><addr-line>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga</wicri:regionArea>
<wicri:noRegion>Malaga</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermin" last="Mayoral">Fermin Mayoral</name>
<affiliation wicri:level="1"><nlm:aff id="aff049"><addr-line>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga</wicri:regionArea>
<wicri:noRegion>Malaga</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name>
<affiliation wicri:level="3"><nlm:aff id="aff050"><addr-line>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania</addr-line>
</nlm:aff>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff052"><addr-line>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
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</affiliation>
</author>
<author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name>
<affiliation wicri:level="3"><nlm:aff id="aff053"><addr-line>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich</wicri:regionArea>
<wicri:noRegion>Juelich</wicri:noRegion>
<wicri:noRegion>Juelich</wicri:noRegion>
<wicri:noRegion>Juelich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fier, Heide" sort="Fier, Heide" uniqKey="Fier H" first="Heide" last="Fier">Heide Fier</name>
<affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Institute for Genomics Mathematics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Genomics Mathematics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of shared risk loci and pathways for bipolar disorder and schizophrenia</title>
<author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J." last="Forstner">Andreas J. Forstner</name>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
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<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Psychiatry (UPK), University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Psychiatry (UPK), University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hecker, Julian" sort="Hecker, Julian" uniqKey="Hecker J" first="Julian" last="Hecker">Julian Hecker</name>
<affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Institute for Genomics Mathematics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Genomics Mathematics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
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</affiliation>
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<author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maaser, Anna" sort="Maaser, Anna" uniqKey="Maaser A" first="Anna" last="Maaser">Anna Maaser</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reinbold, Celine S" sort="Reinbold, Celine S" uniqKey="Reinbold C" first="Céline S." last="Reinbold">Céline S. Reinbold</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich</wicri:regionArea>
<wicri:noRegion>Juelich</wicri:noRegion>
<wicri:noRegion>Juelich</wicri:noRegion>
<wicri:noRegion>Juelich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Leber, Markus" sort="Leber, Markus" uniqKey="Leber M" first="Markus" last="Leber">Markus Leber</name>
<affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Department of Psychiatry & Psychotherapy, University of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry & Psychotherapy, University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Treutlein, Jens" sort="Treutlein, Jens" uniqKey="Treutlein J" first="Jens" last="Treutlein">Jens Treutlein</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Department of Biomedicine and Centre for integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine and Centre for integrative Sequencing, iSEQ, Aarhus University, Aarhus</wicri:regionArea>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff012"><addr-line>The Lundbeck Foundation Initiative for integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>The Lundbeck Foundation Initiative for integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen</wicri:regionArea>
<wicri:noRegion>Aarhus and Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
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</affiliation>
</author>
<author><name sortKey="Streit, Fabian" sort="Streit, Fabian" uniqKey="Streit F" first="Fabian" last="Streit">Fabian Streit</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meier, Sandra" sort="Meier, Sandra" uniqKey="Meier S" first="Sandra" last="Meier">Sandra Meier</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff012"><addr-line>The Lundbeck Foundation Initiative for integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>The Lundbeck Foundation Initiative for integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen</wicri:regionArea>
<wicri:noRegion>Aarhus and Copenhagen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff013"><addr-line>National Centre Register-Based Research, Aarhus University, Aarhus, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>National Centre Register-Based Research, Aarhus University, Aarhus</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacour, Andre" sort="Lacour, Andre" uniqKey="Lacour A" first="André" last="Lacour">André Lacour</name>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H." last="Witt">Stephanie H. Witt</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name>
<affiliation wicri:level="3"><nlm:aff id="aff015"><addr-line>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff017"><addr-line>Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Munich Cluster for Systems Neurology (SyNergy), Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff018"><addr-line>University of Liverpool, Institute of Translational Medicine, Liverpool, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Liverpool, Institute of Translational Medicine, Liverpool</wicri:regionArea>
<wicri:noRegion>Liverpool</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name>
<affiliation wicri:level="3"><nlm:aff id="aff016"><addr-line>Max Planck Institute of Psychiatry, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="3"><nlm:aff id="aff019"><addr-line>Department of Psychiatry, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Psychiatric Center Nordbaden, Wiesloch, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Psychiatric Center Nordbaden, Wiesloch</wicri:regionArea>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name>
<affiliation wicri:level="1"><nlm:aff id="aff020"><addr-line>Psychiatric Center Nordbaden, Wiesloch, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Psychiatric Center Nordbaden, Wiesloch</wicri:regionArea>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
<wicri:noRegion>Wiesloch</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name>
<affiliation wicri:level="1"><nlm:aff id="aff021"><addr-line>Center of Psychiatry Weinsberg, Weinsberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center of Psychiatry Weinsberg, Weinsberg</wicri:regionArea>
<wicri:noRegion>Weinsberg</wicri:noRegion>
<wicri:noRegion>Weinsberg</wicri:noRegion>
<wicri:noRegion>Weinsberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name>
<affiliation wicri:level="3"><nlm:aff id="aff023"><addr-line>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen</wicri:regionArea>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schenk, Lorena M" sort="Schenk, Lorena M" uniqKey="Schenk L" first="Lorena M." last="Schenk">Lorena M. Schenk</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fischer, Sascha B" sort="Fischer, Sascha B" uniqKey="Fischer S" first="Sascha B." last="Fischer">Sascha B. Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sivalingam, Sugirthan" sort="Sivalingam, Sugirthan" uniqKey="Sivalingam S" first="Sugirthan" last="Sivalingam">Sugirthan Sivalingam</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M." last="Czerski">Piotr M. Czerski</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw</wicri:regionArea>
<wicri:noRegion>Warsaw</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
<affiliation wicri:level="3"><nlm:aff id="aff028"><addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D." last="Mckay">James D. Mckay</name>
<affiliation wicri:level="3"><nlm:aff id="aff029"><addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>School of Psychiatry, University of New South Wales, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff031"><addr-line>Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B." last="Mitchell">Philip B. Mitchell</name>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>School of Psychiatry, University of New South Wales, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff031"><addr-line>Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Black Dog Institute, Prince of Wales Hospital, Randwick</wicri:regionArea>
<wicri:noRegion>Randwick</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M." last="Fullerton">Janice M. Fullerton</name>
<affiliation wicri:level="3"><nlm:aff id="aff032"><addr-line>Neuroscience Research Australia, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
<affiliation wicri:level="3"><nlm:aff id="aff032"><addr-line>Neuroscience Research Australia, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W." last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D." last="Gordon">Scott D. Gordon</name>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="aff034"><addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krasnov, Valery" sort="Krasnov, Valery" uniqKey="Krasnov V" first="Valery" last="Krasnov">Valery Krasnov</name>
<affiliation wicri:level="3"><nlm:aff id="aff035"><addr-line>Moscow Research Institute of Psychiatry, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Moscow Research Institute of Psychiatry, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name>
<affiliation wicri:level="3"><nlm:aff id="aff036"><addr-line>Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name>
<affiliation wicri:level="3"><nlm:aff id="aff036"><addr-line>Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name>
<affiliation wicri:level="3"><nlm:aff id="aff037"><addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I." last="Abramova">Lilia I. Abramova</name>
<affiliation wicri:level="3"><nlm:aff id="aff037"><addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S." last="Tiganov">Alexander S. Tiganov</name>
<affiliation wicri:level="3"><nlm:aff id="aff037"><addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Polonikov, Alexey" sort="Polonikov, Alexey" uniqKey="Polonikov A" first="Alexey" last="Polonikov">Alexey Polonikov</name>
<affiliation wicri:level="1"><nlm:aff id="aff038"><addr-line>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk</wicri:regionArea>
<wicri:noRegion>Kursk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff039"><addr-line>Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk</wicri:regionArea>
<wicri:noRegion>Kursk</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name>
<affiliation wicri:level="1"><nlm:aff id="aff040"><addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa</wicri:regionArea>
<wicri:noRegion>Ufa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff041"><addr-line>Department of Genetics and Fundamental Medicine of Bashkir State University, Ufa, Russian Federation</addr-line>
</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Department of Genetics and Fundamental Medicine of Bashkir State University, Ufa</wicri:regionArea>
<wicri:noRegion>Ufa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name>
<affiliation wicri:level="1"><nlm:aff id="aff042"><addr-line>Department of Psychiatry, Dalhousie University, Halifax, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff043"><addr-line>National Institute of Mental Health, Klecany, Czech Republic</addr-line>
</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Mental Health, Klecany</wicri:regionArea>
<wicri:noRegion>Klecany</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name>
<affiliation wicri:level="4"><nlm:aff id="aff044"><addr-line>Montreal Neurological Institute, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff045"><addr-line>Department of Human Genetics, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Human Genetics, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff046"><addr-line>McGill Group for Suicide Studies & Douglas Research Institute, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill Group for Suicide Studies & Douglas Research Institute, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A." last="Rouleau">Guy A. Rouleau</name>
<affiliation wicri:level="4"><nlm:aff id="aff044"><addr-line>Montreal Neurological Institute, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Neurological Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
<affiliation wicri:level="4"><nlm:aff id="aff045"><addr-line>Department of Human Genetics, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Human Genetics, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff046"><addr-line>McGill Group for Suicide Studies & Douglas Research Institute, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill Group for Suicide Studies & Douglas Research Institute, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff047"><addr-line>Department of Psychiatry, McGill University, Montreal, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name>
<affiliation wicri:level="1"><nlm:aff id="aff048"><addr-line>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay</wicri:regionArea>
<wicri:noRegion>Saguenay</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name>
<affiliation wicri:level="1"><nlm:aff id="aff049"><addr-line>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga</wicri:regionArea>
<wicri:noRegion>Malaga</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermin" last="Mayoral">Fermin Mayoral</name>
<affiliation wicri:level="1"><nlm:aff id="aff049"><addr-line>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga</wicri:regionArea>
<wicri:noRegion>Malaga</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name>
<affiliation wicri:level="3"><nlm:aff id="aff050"><addr-line>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania</addr-line>
</nlm:aff>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<affiliation wicri:level="3"><nlm:aff id="aff014"><addr-line>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff052"><addr-line>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name>
<affiliation wicri:level="3"><nlm:aff id="aff053"><addr-line>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<affiliation wicri:level="3"><nlm:aff id="aff010"><addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich</wicri:regionArea>
<wicri:noRegion>Juelich</wicri:noRegion>
<wicri:noRegion>Juelich</wicri:noRegion>
<wicri:noRegion>Juelich</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fier, Heide" sort="Fier, Heide" uniqKey="Fier H" first="Heide" last="Fier">Heide Fier</name>
<affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Institute for Genomics Mathematics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Genomics Mathematics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genomics, Life & Brain Center, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (<italic>p = 1</italic>
.<italic>46x10</italic>
<sup><italic>-8</italic>
</sup>
). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near <italic>TRANK1</italic>
, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders.</p>
</div>
</front>
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</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Computational Biology</subject>
<subj-group><subject>Genome Analysis</subject>
<subj-group><subject>Genomic Databases</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Genetics</subject>
<subj-group><subject>Genomics</subject>
<subj-group><subject>Genome Analysis</subject>
<subj-group><subject>Genomic Databases</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Identification of shared risk loci and pathways for bipolar disorder and schizophrenia</article-title>
<alt-title alt-title-type="running-head">Shared bipolar disorder and schizophrenia risk loci</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Forstner</surname>
<given-names>Andreas J.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Hecker</surname>
<given-names>Julian</given-names>
</name>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hofmann</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff007"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-9440-0712</contrib-id>
<name><surname>Maaser</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-3394-3158</contrib-id>
<name><surname>Reinbold</surname>
<given-names>Céline S.</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mühleisen</surname>
<given-names>Thomas W.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff008"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leber</surname>
<given-names>Markus</given-names>
</name>
<xref ref-type="aff" rid="aff009"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Strohmaier</surname>
<given-names>Jana</given-names>
</name>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Degenhardt</surname>
<given-names>Franziska</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Treutlein</surname>
<given-names>Jens</given-names>
</name>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mattheisen</surname>
<given-names>Manuel</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff011"><sup>11</sup>
</xref>
<xref ref-type="aff" rid="aff012"><sup>12</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schumacher</surname>
<given-names>Johannes</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0003-1080-4339</contrib-id>
<name><surname>Streit</surname>
<given-names>Fabian</given-names>
</name>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meier</surname>
<given-names>Sandra</given-names>
</name>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
<xref ref-type="aff" rid="aff012"><sup>12</sup>
</xref>
<xref ref-type="aff" rid="aff013"><sup>13</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-2786-8200</contrib-id>
<name><surname>Herms</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoffmann</surname>
<given-names>Per</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lacour</surname>
<given-names>André</given-names>
</name>
<xref ref-type="aff" rid="aff014"><sup>14</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-1571-1468</contrib-id>
<name><surname>Witt</surname>
<given-names>Stephanie H.</given-names>
</name>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reif</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="aff015"><sup>15</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Müller-Myhsok</surname>
<given-names>Bertram</given-names>
</name>
<xref ref-type="aff" rid="aff016"><sup>16</sup>
</xref>
<xref ref-type="aff" rid="aff017"><sup>17</sup>
</xref>
<xref ref-type="aff" rid="aff018"><sup>18</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lucae</surname>
<given-names>Susanne</given-names>
</name>
<xref ref-type="aff" rid="aff016"><sup>16</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maier</surname>
<given-names>Wolfgang</given-names>
</name>
<xref ref-type="aff" rid="aff019"><sup>19</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schwarz</surname>
<given-names>Markus</given-names>
</name>
<xref ref-type="aff" rid="aff020"><sup>20</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vedder</surname>
<given-names>Helmut</given-names>
</name>
<xref ref-type="aff" rid="aff020"><sup>20</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kammerer-Ciernioch</surname>
<given-names>Jutta</given-names>
</name>
<xref ref-type="aff" rid="aff021"><sup>21</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pfennig</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="aff022"><sup>22</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bauer</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="aff022"><sup>22</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hautzinger</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="aff023"><sup>23</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moebus</surname>
<given-names>Susanne</given-names>
</name>
<xref ref-type="aff" rid="aff024"><sup>24</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schenk</surname>
<given-names>Lorena M.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0003-0336-0784</contrib-id>
<name><surname>Fischer</surname>
<given-names>Sascha B.</given-names>
</name>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-5239-5137</contrib-id>
<name><surname>Sivalingam</surname>
<given-names>Sugirthan</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Czerski</surname>
<given-names>Piotr M.</given-names>
</name>
<xref ref-type="aff" rid="aff025"><sup>25</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-6621-3493</contrib-id>
<name><surname>Hauser</surname>
<given-names>Joanna</given-names>
</name>
<xref ref-type="aff" rid="aff025"><sup>25</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lissowska</surname>
<given-names>Jolanta</given-names>
</name>
<xref ref-type="aff" rid="aff026"><sup>26</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szeszenia-Dabrowska</surname>
<given-names>Neonila</given-names>
</name>
<xref ref-type="aff" rid="aff027"><sup>27</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brennan</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="aff028"><sup>28</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McKay</surname>
<given-names>James D.</given-names>
</name>
<xref ref-type="aff" rid="aff029"><sup>29</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wright</surname>
<given-names>Adam</given-names>
</name>
<xref ref-type="aff" rid="aff030"><sup>30</sup>
</xref>
<xref ref-type="aff" rid="aff031"><sup>31</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-7954-5235</contrib-id>
<name><surname>Mitchell</surname>
<given-names>Philip B.</given-names>
</name>
<xref ref-type="aff" rid="aff030"><sup>30</sup>
</xref>
<xref ref-type="aff" rid="aff031"><sup>31</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fullerton</surname>
<given-names>Janice M.</given-names>
</name>
<xref ref-type="aff" rid="aff032"><sup>32</sup>
</xref>
<xref ref-type="aff" rid="aff033"><sup>33</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0003-2967-9662</contrib-id>
<name><surname>Schofield</surname>
<given-names>Peter R.</given-names>
</name>
<xref ref-type="aff" rid="aff032"><sup>32</sup>
</xref>
<xref ref-type="aff" rid="aff033"><sup>33</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Montgomery</surname>
<given-names>Grant W.</given-names>
</name>
<xref ref-type="aff" rid="aff034"><sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Medland</surname>
<given-names>Sarah E.</given-names>
</name>
<xref ref-type="aff" rid="aff034"><sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0001-7623-328X</contrib-id>
<name><surname>Gordon</surname>
<given-names>Scott D.</given-names>
</name>
<xref ref-type="aff" rid="aff034"><sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martin</surname>
<given-names>Nicholas G.</given-names>
</name>
<xref ref-type="aff" rid="aff034"><sup>34</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krasnov</surname>
<given-names>Valery</given-names>
</name>
<xref ref-type="aff" rid="aff035"><sup>35</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chuchalin</surname>
<given-names>Alexander</given-names>
</name>
<xref ref-type="aff" rid="aff036"><sup>36</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Babadjanova</surname>
<given-names>Gulja</given-names>
</name>
<xref ref-type="aff" rid="aff036"><sup>36</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pantelejeva</surname>
<given-names>Galina</given-names>
</name>
<xref ref-type="aff" rid="aff037"><sup>37</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abramova</surname>
<given-names>Lilia I.</given-names>
</name>
<xref ref-type="aff" rid="aff037"><sup>37</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tiganov</surname>
<given-names>Alexander S.</given-names>
</name>
<xref ref-type="aff" rid="aff037"><sup>37</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Polonikov</surname>
<given-names>Alexey</given-names>
</name>
<xref ref-type="aff" rid="aff038"><sup>38</sup>
</xref>
<xref ref-type="aff" rid="aff039"><sup>39</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khusnutdinova</surname>
<given-names>Elza</given-names>
</name>
<xref ref-type="aff" rid="aff040"><sup>40</sup>
</xref>
<xref ref-type="aff" rid="aff041"><sup>41</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0001-9544-3944</contrib-id>
<name><surname>Alda</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="aff042"><sup>42</sup>
</xref>
<xref ref-type="aff" rid="aff043"><sup>43</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-7799-5531</contrib-id>
<name><surname>Cruceanu</surname>
<given-names>Cristiana</given-names>
</name>
<xref ref-type="aff" rid="aff044"><sup>44</sup>
</xref>
<xref ref-type="aff" rid="aff045"><sup>45</sup>
</xref>
<xref ref-type="aff" rid="aff046"><sup>46</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rouleau</surname>
<given-names>Guy A.</given-names>
</name>
<xref ref-type="aff" rid="aff044"><sup>44</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Turecki</surname>
<given-names>Gustavo</given-names>
</name>
<xref ref-type="aff" rid="aff045"><sup>45</sup>
</xref>
<xref ref-type="aff" rid="aff046"><sup>46</sup>
</xref>
<xref ref-type="aff" rid="aff047"><sup>47</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Laprise</surname>
<given-names>Catherine</given-names>
</name>
<xref ref-type="aff" rid="aff048"><sup>48</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rivas</surname>
<given-names>Fabio</given-names>
</name>
<xref ref-type="aff" rid="aff049"><sup>49</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-9710-9672</contrib-id>
<name><surname>Mayoral</surname>
<given-names>Fermin</given-names>
</name>
<xref ref-type="aff" rid="aff049"><sup>49</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kogevinas</surname>
<given-names>Manolis</given-names>
</name>
<xref ref-type="aff" rid="aff050"><sup>50</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grigoroiu-Serbanescu</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="aff051"><sup>51</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Becker</surname>
<given-names>Tim</given-names>
</name>
<xref ref-type="aff" rid="aff014"><sup>14</sup>
</xref>
<xref ref-type="aff" rid="aff052"><sup>52</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schulze</surname>
<given-names>Thomas G.</given-names>
</name>
<xref ref-type="aff" rid="aff053"><sup>53</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-5236-6149</contrib-id>
<name><surname>Rietschel</surname>
<given-names>Marcella</given-names>
</name>
<xref ref-type="aff" rid="aff010"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cichon</surname>
<given-names>Sven</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff004"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff005"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff008"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fier</surname>
<given-names>Heide</given-names>
</name>
<xref ref-type="aff" rid="aff006"><sup>6</sup>
</xref>
<xref ref-type="author-notes" rid="econtrib001"><sup>‡</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nöthen</surname>
<given-names>Markus M.</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="econtrib001"><sup>‡</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Institute of Human Genetics, University of Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>Department of Psychiatry (UPK), University of Basel, Basel, Switzerland</addr-line>
</aff>
<aff id="aff004"><label>4</label>
<addr-line>Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland</addr-line>
</aff>
<aff id="aff005"><label>5</label>
<addr-line>Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland</addr-line>
</aff>
<aff id="aff006"><label>6</label>
<addr-line>Institute for Genomics Mathematics, University of Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff007"><label>7</label>
<addr-line>Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff008"><label>8</label>
<addr-line>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany</addr-line>
</aff>
<aff id="aff009"><label>9</label>
<addr-line>Department of Psychiatry & Psychotherapy, University of Cologne, Cologne, Germany</addr-line>
</aff>
<aff id="aff010"><label>10</label>
<addr-line>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany</addr-line>
</aff>
<aff id="aff011"><label>11</label>
<addr-line>Department of Biomedicine and Centre for integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark</addr-line>
</aff>
<aff id="aff012"><label>12</label>
<addr-line>The Lundbeck Foundation Initiative for integrative Psychiatric Research, iPSYCH, Aarhus and Copenhagen, Denmark</addr-line>
</aff>
<aff id="aff013"><label>13</label>
<addr-line>National Centre Register-Based Research, Aarhus University, Aarhus, Denmark</addr-line>
</aff>
<aff id="aff014"><label>14</label>
<addr-line>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany</addr-line>
</aff>
<aff id="aff015"><label>15</label>
<addr-line>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany</addr-line>
</aff>
<aff id="aff016"><label>16</label>
<addr-line>Max Planck Institute of Psychiatry, Munich, Germany</addr-line>
</aff>
<aff id="aff017"><label>17</label>
<addr-line>Munich Cluster for Systems Neurology (SyNergy), Munich, Germany</addr-line>
</aff>
<aff id="aff018"><label>18</label>
<addr-line>University of Liverpool, Institute of Translational Medicine, Liverpool, United Kingdom</addr-line>
</aff>
<aff id="aff019"><label>19</label>
<addr-line>Department of Psychiatry, University of Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff020"><label>20</label>
<addr-line>Psychiatric Center Nordbaden, Wiesloch, Germany</addr-line>
</aff>
<aff id="aff021"><label>21</label>
<addr-line>Center of Psychiatry Weinsberg, Weinsberg, Germany</addr-line>
</aff>
<aff id="aff022"><label>22</label>
<addr-line>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany</addr-line>
</aff>
<aff id="aff023"><label>23</label>
<addr-line>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen, Germany</addr-line>
</aff>
<aff id="aff024"><label>24</label>
<addr-line>Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany</addr-line>
</aff>
<aff id="aff025"><label>25</label>
<addr-line>Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland</addr-line>
</aff>
<aff id="aff026"><label>26</label>
<addr-line>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw, Poland</addr-line>
</aff>
<aff id="aff027"><label>27</label>
<addr-line>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland</addr-line>
</aff>
<aff id="aff028"><label>28</label>
<addr-line>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line>
</aff>
<aff id="aff029"><label>29</label>
<addr-line>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France</addr-line>
</aff>
<aff id="aff030"><label>30</label>
<addr-line>School of Psychiatry, University of New South Wales, Randwick, Australia</addr-line>
</aff>
<aff id="aff031"><label>31</label>
<addr-line>Black Dog Institute, Prince of Wales Hospital, Randwick, Australia</addr-line>
</aff>
<aff id="aff032"><label>32</label>
<addr-line>Neuroscience Research Australia, Sydney, Australia</addr-line>
</aff>
<aff id="aff033"><label>33</label>
<addr-line>School of Medical Sciences Faculty of Medicine, University of New South Wales, Sydney, Australia</addr-line>
</aff>
<aff id="aff034"><label>34</label>
<addr-line>Queensland Institute of Medical Research (QIMR), Brisbane, Australia</addr-line>
</aff>
<aff id="aff035"><label>35</label>
<addr-line>Moscow Research Institute of Psychiatry, Moscow, Russian Federation</addr-line>
</aff>
<aff id="aff036"><label>36</label>
<addr-line>Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation</addr-line>
</aff>
<aff id="aff037"><label>37</label>
<addr-line>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation</addr-line>
</aff>
<aff id="aff038"><label>38</label>
<addr-line>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation</addr-line>
</aff>
<aff id="aff039"><label>39</label>
<addr-line>Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russian Federation</addr-line>
</aff>
<aff id="aff040"><label>40</label>
<addr-line>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russian Federation</addr-line>
</aff>
<aff id="aff041"><label>41</label>
<addr-line>Department of Genetics and Fundamental Medicine of Bashkir State University, Ufa, Russian Federation</addr-line>
</aff>
<aff id="aff042"><label>42</label>
<addr-line>Department of Psychiatry, Dalhousie University, Halifax, Canada</addr-line>
</aff>
<aff id="aff043"><label>43</label>
<addr-line>National Institute of Mental Health, Klecany, Czech Republic</addr-line>
</aff>
<aff id="aff044"><label>44</label>
<addr-line>Montreal Neurological Institute, McGill University, Montreal, Canada</addr-line>
</aff>
<aff id="aff045"><label>45</label>
<addr-line>Department of Human Genetics, McGill University, Montreal, Canada</addr-line>
</aff>
<aff id="aff046"><label>46</label>
<addr-line>McGill Group for Suicide Studies & Douglas Research Institute, Montreal, Canada</addr-line>
</aff>
<aff id="aff047"><label>47</label>
<addr-line>Department of Psychiatry, McGill University, Montreal, Canada</addr-line>
</aff>
<aff id="aff048"><label>48</label>
<addr-line>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, Canada</addr-line>
</aff>
<aff id="aff049"><label>49</label>
<addr-line>Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain</addr-line>
</aff>
<aff id="aff050"><label>50</label>
<addr-line>Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain</addr-line>
</aff>
<aff id="aff051"><label>51</label>
<addr-line>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania</addr-line>
</aff>
<aff id="aff052"><label>52</label>
<addr-line>Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany</addr-line>
</aff>
<aff id="aff053"><label>53</label>
<addr-line>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Walss-Bass</surname>
<given-names>Consuelo</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>University of Texas Health Science Center at Houston, UNITED STATES</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceptualization:</bold>
AJF J. Hecker HF MMN.</p>
</list-item>
<list-item><p><bold>Data curation:</bold>
AJF J. Hecker HF MMN.</p>
</list-item>
<list-item><p><bold>Formal analysis:</bold>
AJF J. Hecker AH AM CSR LMS SBF SS MR SC HF MMN.</p>
</list-item>
<list-item><p><bold>Funding acquisition:</bold>
MB PBM NGM MA CL MG-S TGS MR SC MMN.</p>
</list-item>
<list-item><p><bold>Investigation:</bold>
AJF J. Hecker AH AM CSR TWM ML FD JT MM J. Schumacher FS S. Meier SH PH AL SHW TB HF.</p>
</list-item>
<list-item><p><bold>Methodology:</bold>
AJF J. Hecker HF MMN.</p>
</list-item>
<list-item><p><bold>Project administration:</bold>
AJF HF MMN.</p>
</list-item>
<list-item><p><bold>Resources:</bold>
J. Strohmaier FS AR BM-M SL WM MS HV JK-C A. Pfennig MB MH S. Moebus PMC J. Hauser JL NS-D PB JDM AW PBM JMF PRS GWM SEM SDG NGM VK AC GB GP LIA AST A. Polonikov EK MA CC GAR GT CL FR FM MK MG-S TGS MR MMN.</p>
</list-item>
<list-item><p><bold>Software:</bold>
J. Hecker AH AM CSR HF.</p>
</list-item>
<list-item><p><bold>Supervision:</bold>
AJF HF MMN.</p>
</list-item>
<list-item><p><bold>Validation:</bold>
AJF J. Hecker AM CSR HF MMN.</p>
</list-item>
<list-item><p><bold>Visualization:</bold>
AJF J. Hecker AH AM CSR HF MMN.</p>
</list-item>
<list-item><p><bold>Writing – original draft:</bold>
AJF J. Hecker AH CSR HF MMN.</p>
</list-item>
<list-item><p><bold>Writing – review & editing:</bold>
AC AH AJF AL AM A. Pfennig A. Polonikov AR AST AW BM-M CC CL CSR EK FD FR FM FS GAR GB GP GT GWM HF HV JDM J. Hecker J. Hauser JK-C JL JMF J. Strohmaier J. Schumacher JT LIA LMS MA MB MG-S MH MK ML MM MMN MR MS NGM NS-D PB PBM PH PMC PRS SBF SC SDG SEM SH SHW SL S. Meier S. Moebus SS TB TGS TWM VK WM.</p>
</list-item>
</list>
</p>
</fn>
<fn fn-type="other" id="econtrib001"><p>‡ These authors also contributed equally to this work.</p>
</fn>
<corresp id="cor001">* E-mail: <email>markus.noethen@uni-bonn.de</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>6</day>
<month>2</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>12</volume>
<issue>2</issue>
<elocation-id>e0171595</elocation-id>
<history><date date-type="received"><day>10</day>
<month>10</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>23</day>
<month>1</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© 2017 Forstner et al</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>Forstner et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pone.0171595.pdf"></self-uri>
<abstract><p>Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (<italic>p = 1</italic>
.<italic>46x10</italic>
<sup><italic>-8</italic>
</sup>
). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near <italic>TRANK1</italic>
, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders.</p>
</abstract>
<funding-group><funding-statement>The study was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A to M.M.N. and S.C., grant 01ZX1314G to M.R.). M.M.N. is a member of the DFG-funded Excellence-Cluster ImmunoSensation. M.M.N. also received support from the Alfried Krupp von Bohlen und Halbach-Stiftung. The study was supported by the German Research Foundation (DFG; grant FOR2107; RI908/11-1 to M.R.; NO246/10-1 to M.M.N.). The study was also supported by the Swiss National Science Foundation (SNSF, grant 156791 to S.C.). M.G.S. received grant no. 89/2012 from UEFISCDI, Romania. Canadian patients were genotyped within the ConLiGen project (<ext-link ext-link-type="uri" xlink:href="http://www.ConLiGen.org">www.ConLiGen.org</ext-link>
), with the support of a grant from the DFG to M.R., M.B., and T.G.S. (RI 908/7-1). Controls for Germany II were drawn from the Heinz Nixdorf Recall Study (HNR) cohort, which was established with the support of the Heinz Nixdorf Foundation. Recruitment of the Australian sample was supported by an Australian NHMRC program grant (number 1037196). The recruitment of the Canadian patients was supported by a grant from the Canadian Institutes of Health Research #64410 to M.A. The study also used data generated by the GABRIEL consortium (controls for the sample Russia). Funding for the generation of these data was provided by the European Commission as part of GABRIEL contract number 018996 under the Integrated Program LSH-2004-1.2.5-1. Post genomic approaches to understand the molecular basis of asthma aiming at a preventive or therapeutic control and the Wellcome Trust under award 084703. Canadian controls were drawn from the French Canadian study (SLSJ), which was supported in part by the Canada Research Chair Environment and genetics of respiratory diseases and allergy, the Canadian Institutes of Health Research (Operating grant No. MOP-13506), and the Quebec Respiratory Network of the Fonds de rechercheen Santé du Québec (FRQS). Polish controls were recruited by the International Agency for Research on Cancer (IARC)/Centre National de Genotypage (CNG) GWAS Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="1"></table-count>
<page-count count="14"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>Espagne</li>
<li>France</li>
<li>Pologne</li>
<li>Roumanie</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>République tchèque</li>
<li>Suisse</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>Catalogne</li>
<li>District de Cologne</li>
<li>District de Darmstadt</li>
<li>District de Dresde</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>District de Tübingen</li>
<li>District fédéral central</li>
<li>Hesse (Land)</li>
<li>Nouvelle-Galles du Sud</li>
<li>Québec</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>Rhône-Alpes</li>
<li>Saxe (Land)</li>
</region>
<settlement><li>Barcelone</li>
<li>Bonn</li>
<li>Dresde</li>
<li>Francfort-sur-le-Main</li>
<li>Lyon</li>
<li>Mannheim</li>
<li>Montréal</li>
<li>Moscou</li>
<li>Munich</li>
<li>Sydney</li>
<li>Tübingen</li>
</settlement>
<orgName><li>Université McGill</li>
</orgName>
</list>
<tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J." last="Forstner">Andreas J. Forstner</name>
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<name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name>
<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name>
<name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name>
<name sortKey="Fier, Heide" sort="Fier, Heide" uniqKey="Fier H" first="Heide" last="Fier">Heide Fier</name>
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<name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name>
<name sortKey="Hecker, Julian" sort="Hecker, Julian" uniqKey="Hecker J" first="Julian" last="Hecker">Julian Hecker</name>
<name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name>
<name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name>
<name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name>
<name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name>
<name sortKey="Lacour, Andre" sort="Lacour, Andre" uniqKey="Lacour A" first="André" last="Lacour">André Lacour</name>
<name sortKey="Leber, Markus" sort="Leber, Markus" uniqKey="Leber M" first="Markus" last="Leber">Markus Leber</name>
<name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name>
<name sortKey="Maaser, Anna" sort="Maaser, Anna" uniqKey="Maaser A" first="Anna" last="Maaser">Anna Maaser</name>
<name sortKey="Maaser, Anna" sort="Maaser, Anna" uniqKey="Maaser A" first="Anna" last="Maaser">Anna Maaser</name>
<name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name>
<name sortKey="Meier, Sandra" sort="Meier, Sandra" uniqKey="Meier S" first="Sandra" last="Meier">Sandra Meier</name>
<name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M." last="Nöthen">Markus M. Nöthen</name>
<name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name>
<name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name>
<name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<name sortKey="Schenk, Lorena M" sort="Schenk, Lorena M" uniqKey="Schenk L" first="Lorena M." last="Schenk">Lorena M. Schenk</name>
<name sortKey="Schenk, Lorena M" sort="Schenk, Lorena M" uniqKey="Schenk L" first="Lorena M." last="Schenk">Lorena M. Schenk</name>
<name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G." last="Schulze">Thomas G. Schulze</name>
<name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name>
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<name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name>
<name sortKey="Sivalingam, Sugirthan" sort="Sivalingam, Sugirthan" uniqKey="Sivalingam S" first="Sugirthan" last="Sivalingam">Sugirthan Sivalingam</name>
<name sortKey="Sivalingam, Sugirthan" sort="Sivalingam, Sugirthan" uniqKey="Sivalingam S" first="Sugirthan" last="Sivalingam">Sugirthan Sivalingam</name>
<name sortKey="Streit, Fabian" sort="Streit, Fabian" uniqKey="Streit F" first="Fabian" last="Streit">Fabian Streit</name>
<name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name>
<name sortKey="Treutlein, Jens" sort="Treutlein, Jens" uniqKey="Treutlein J" first="Jens" last="Treutlein">Jens Treutlein</name>
<name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name>
<name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H." last="Witt">Stephanie H. Witt</name>
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<country name="Suisse"><noRegion><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J." last="Forstner">Andreas J. Forstner</name>
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<name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
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<name sortKey="Fischer, Sascha B" sort="Fischer, Sascha B" uniqKey="Fischer S" first="Sascha B." last="Fischer">Sascha B. Fischer</name>
<name sortKey="Fischer, Sascha B" sort="Fischer, Sascha B" uniqKey="Fischer S" first="Sascha B." last="Fischer">Sascha B. Fischer</name>
<name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J." last="Forstner">Andreas J. Forstner</name>
<name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J." last="Forstner">Andreas J. Forstner</name>
<name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
<name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W." last="Mühleisen">Thomas W. Mühleisen</name>
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<name sortKey="Reinbold, Celine S" sort="Reinbold, Celine S" uniqKey="Reinbold C" first="Céline S." last="Reinbold">Céline S. Reinbold</name>
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<name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name>
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<country name="Canada"><noRegion><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name>
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<name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name>
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<name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
<name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
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<country name="République tchèque"><noRegion><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name>
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<country name="Espagne"><noRegion><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name>
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</noRegion>
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</tree>
</affiliations>
</record>
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