Outcome of intracerebral hemorrhage associated with different oral anticoagulants
Identifieur interne : 000164 ( Pmc/Checkpoint ); précédent : 000163; suivant : 000165Outcome of intracerebral hemorrhage associated with different oral anticoagulants
Auteurs : Duncan Wilson ; David J. Seiffge ; Christopher Traenka ; Ghazala Basir ; Jan C. Purrucker ; Timolaos Rizos ; Oluwaseun A. Sobowale ; Hanne Sallinen ; Shin-Joe Yeh ; Teddy Y. Wu ; Marc Ferrigno ; Rik Houben ; Floris H. B. M. Schreuder ; Luke A. Perry ; Jun Tanaka ; Marion Boulanger ; Rustam Al-Shahi Salman ; Hans R. J Ger ; Gareth Ambler ; Clare Shakeshaft ; Yusuke Yakushiji ; Philip M. C. Choi ; Julie Staals ; Charlotte Cordonnier ; Jiann-Shing Jeng ; Roland Veltkamp ; Dar Dowlatshahi ; Stefan T. Engelter ; Adrian R. Parry-Jones ; Atte Meretoja ; David J. WerringSource :
- Neurology [ 0028-3878 ] ; 2017.
Abstract
In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) and vitamin K antagonist–associated ICH (VKA-ICH).
We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours.
We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6–38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0–27.9) for VKA-ICH (
In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.
Url:
DOI: 10.1212/WNL.0000000000003886
PubMed: 28381513
PubMed Central: 5409844
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Purrucker</name></author><author><name sortKey="Rizos, Timolaos" sort="Rizos, Timolaos" uniqKey="Rizos T" first="Timolaos" last="Rizos">Timolaos Rizos</name></author><author><name sortKey="Sobowale, Oluwaseun A" sort="Sobowale, Oluwaseun A" uniqKey="Sobowale O" first="Oluwaseun A." last="Sobowale">Oluwaseun A. Sobowale</name></author><author><name sortKey="Sallinen, Hanne" sort="Sallinen, Hanne" uniqKey="Sallinen H" first="Hanne" last="Sallinen">Hanne Sallinen</name></author><author><name sortKey="Yeh, Shin Joe" sort="Yeh, Shin Joe" uniqKey="Yeh S" first="Shin-Joe" last="Yeh">Shin-Joe Yeh</name></author><author><name sortKey="Wu, Teddy Y" sort="Wu, Teddy Y" uniqKey="Wu T" first="Teddy Y." last="Wu">Teddy Y. Wu</name></author><author><name sortKey="Ferrigno, Marc" sort="Ferrigno, Marc" uniqKey="Ferrigno M" first="Marc" last="Ferrigno">Marc Ferrigno</name></author><author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name></author><author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name></author><author><name sortKey="Perry, Luke A" sort="Perry, Luke A" uniqKey="Perry L" first="Luke A." last="Perry">Luke A. Perry</name></author><author><name sortKey="Tanaka, Jun" sort="Tanaka, Jun" uniqKey="Tanaka J" first="Jun" last="Tanaka">Jun Tanaka</name></author><author><name sortKey="Boulanger, Marion" sort="Boulanger, Marion" uniqKey="Boulanger M" first="Marion" last="Boulanger">Marion Boulanger</name></author><author><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name></author><author><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name></author><author><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name></author><author><name sortKey="Shakeshaft, Clare" sort="Shakeshaft, Clare" uniqKey="Shakeshaft C" first="Clare" last="Shakeshaft">Clare Shakeshaft</name></author><author><name sortKey="Yakushiji, Yusuke" sort="Yakushiji, Yusuke" uniqKey="Yakushiji Y" first="Yusuke" last="Yakushiji">Yusuke Yakushiji</name></author><author><name sortKey="Choi, Philip M C" sort="Choi, Philip M C" uniqKey="Choi P" first="Philip M. C." last="Choi">Philip M. C. Choi</name></author><author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name></author><author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name></author><author><name sortKey="Jeng, Jiann Shing" sort="Jeng, Jiann Shing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name></author><author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name></author><author><name sortKey="Dowlatshahi, Dar" sort="Dowlatshahi, Dar" uniqKey="Dowlatshahi D" first="Dar" last="Dowlatshahi">Dar Dowlatshahi</name></author><author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name></author><author><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name></author><author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name></author><author><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J." last="Werring">David J. Werring</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28381513</idno><idno type="pmc">5409844</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409844</idno><idno type="RBID">PMC:5409844</idno><idno type="doi">10.1212/WNL.0000000000003886</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002797</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002797</idno><idno type="wicri:Area/Pmc/Curation">002647</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002647</idno><idno type="wicri:Area/Pmc/Checkpoint">000164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Outcome of intracerebral hemorrhage associated with different oral anticoagulants</title><author><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name></author><author><name sortKey="Seiffge, David J" sort="Seiffge, David J" uniqKey="Seiffge D" first="David J." last="Seiffge">David J. Seiffge</name></author><author><name sortKey="Traenka, Christopher" sort="Traenka, Christopher" uniqKey="Traenka C" first="Christopher" last="Traenka">Christopher Traenka</name></author><author><name sortKey="Basir, Ghazala" sort="Basir, Ghazala" uniqKey="Basir G" first="Ghazala" last="Basir">Ghazala Basir</name></author><author><name sortKey="Purrucker, Jan C" sort="Purrucker, Jan C" uniqKey="Purrucker J" first="Jan C." last="Purrucker">Jan C. Purrucker</name></author><author><name sortKey="Rizos, Timolaos" sort="Rizos, Timolaos" uniqKey="Rizos T" first="Timolaos" last="Rizos">Timolaos Rizos</name></author><author><name sortKey="Sobowale, Oluwaseun A" sort="Sobowale, Oluwaseun A" uniqKey="Sobowale O" first="Oluwaseun A." last="Sobowale">Oluwaseun A. Sobowale</name></author><author><name sortKey="Sallinen, Hanne" sort="Sallinen, Hanne" uniqKey="Sallinen H" first="Hanne" last="Sallinen">Hanne Sallinen</name></author><author><name sortKey="Yeh, Shin Joe" sort="Yeh, Shin Joe" uniqKey="Yeh S" first="Shin-Joe" last="Yeh">Shin-Joe Yeh</name></author><author><name sortKey="Wu, Teddy Y" sort="Wu, Teddy Y" uniqKey="Wu T" first="Teddy Y." last="Wu">Teddy Y. Wu</name></author><author><name sortKey="Ferrigno, Marc" sort="Ferrigno, Marc" uniqKey="Ferrigno M" first="Marc" last="Ferrigno">Marc Ferrigno</name></author><author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name></author><author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name></author><author><name sortKey="Perry, Luke A" sort="Perry, Luke A" uniqKey="Perry L" first="Luke A." last="Perry">Luke A. Perry</name></author><author><name sortKey="Tanaka, Jun" sort="Tanaka, Jun" uniqKey="Tanaka J" first="Jun" last="Tanaka">Jun Tanaka</name></author><author><name sortKey="Boulanger, Marion" sort="Boulanger, Marion" uniqKey="Boulanger M" first="Marion" last="Boulanger">Marion Boulanger</name></author><author><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name></author><author><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name></author><author><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name></author><author><name sortKey="Shakeshaft, Clare" sort="Shakeshaft, Clare" uniqKey="Shakeshaft C" first="Clare" last="Shakeshaft">Clare Shakeshaft</name></author><author><name sortKey="Yakushiji, Yusuke" sort="Yakushiji, Yusuke" uniqKey="Yakushiji Y" first="Yusuke" last="Yakushiji">Yusuke Yakushiji</name></author><author><name sortKey="Choi, Philip M C" sort="Choi, Philip M C" uniqKey="Choi P" first="Philip M. C." last="Choi">Philip M. C. Choi</name></author><author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name></author><author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name></author><author><name sortKey="Jeng, Jiann Shing" sort="Jeng, Jiann Shing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name></author><author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name></author><author><name sortKey="Dowlatshahi, Dar" sort="Dowlatshahi, Dar" uniqKey="Dowlatshahi D" first="Dar" last="Dowlatshahi">Dar Dowlatshahi</name></author><author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name></author><author><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name></author><author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name></author><author><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J." last="Werring">David J. Werring</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) and vitamin K antagonist–associated ICH (VKA-ICH).</p></sec><sec><title>Methods:</title><p>We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours.</p></sec><sec><title>Results:</title><p>We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6–38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0–27.9) for VKA-ICH (<italic>p</italic> = 0.78). We did not find any difference between NOAC-ICH and VKA-ICH for all-cause mortality within 90 days (33% for NOAC-ICH vs 31% for VKA-ICH [<italic>p</italic> = 0.64]; adjusted Cox hazard ratio (for NOAC-ICH vs VKA-ICH) 0.93 [95% confidence interval (CI) 0.52–1.64] [<italic>p</italic> = 0.79]), the rate of HE (NOAC-ICH n = 29/48 [40%] vs VKA-ICH n = 93/140 [34%] [<italic>p</italic> = 0.45]), or functional outcome at hospital discharge (NOAC-ICH vs VKA-ICH odds ratio 0.47; 95% CI 0.18–1.19 [<italic>p</italic> = 0.11]).</p></sec><sec><title>Conclusions:</title><p>In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ruff, Ct" uniqKey="Ruff C">CT Ruff</name></author><author><name sortKey="Giugliano, Rp" uniqKey="Giugliano R">RP 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sortKey="Klijn, Cj" uniqKey="Klijn C">CJ Klijn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sprigg, N" uniqKey="Sprigg N">N Sprigg</name></author><author><name sortKey="Renton, Cj" uniqKey="Renton C">CJ Renton</name></author><author><name sortKey="Dineen, Ra" uniqKey="Dineen R">RA Dineen</name></author><author><name sortKey="Kwong, Y" uniqKey="Kwong Y">Y Kwong</name></author><author><name sortKey="Bath, Pm" uniqKey="Bath P">PM Bath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Cs" uniqKey="Anderson C">CS Anderson</name></author><author><name sortKey="Heeley, E" uniqKey="Heeley E">E Heeley</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-id journal-id-type="iso-abbrev">Neurology</journal-id><journal-id journal-id-type="hwp">neurology</journal-id><journal-id journal-id-type="publisher-id">neur</journal-id><journal-id journal-id-type="pmc">neurology</journal-id><journal-id journal-id-type="publisher-id">NEUROLOGY</journal-id><journal-title-group><journal-title>Neurology</journal-title></journal-title-group><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name><publisher-loc>Hagerstown, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28381513</article-id><article-id pub-id-type="pmc">5409844</article-id><article-id pub-id-type="publisher-id">NEUROLOGY2016757070</article-id><article-id pub-id-type="doi">10.1212/WNL.0000000000003886</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>7</subject><subject>17</subject><subject>23</subject><subject>112</subject><subject>119</subject></subj-group><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Outcome of intracerebral hemorrhage associated with different oral anticoagulants</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wilson</surname><given-names>Duncan</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Seiffge</surname><given-names>David J.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Advisory board: Bayer, Pfizer</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>University Hospital Basel Science Fonds (personal fellowship)</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Swiss Heart Foundation</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Traenka</surname><given-names>Christopher</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>(1) Swiss Heart Foundation</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Basir</surname><given-names>Ghazala</given-names></name><degrees>MBBS, FCPS</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Purrucker</surname><given-names>Jan C.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Boehringer Ingelheim, speakers honoraria (outside the submitted work)Pfizer, travel and speakers honoraria (outside the submitted work)</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Rizos</surname><given-names>Timolaos</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>TR received consulting honoraria, speakers honoraria andtravel support from BMS Pfizer, Boehringer Ingelheim,Bayer HealthCare and Daiichi Sankyo.</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>TR received consulting honoraria, speakers honoraria andtravel support from BMS Pfizer, Boehringer Ingelheim,Bayer HealthCare and Daiichi Sankyo.</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Sobowale</surname><given-names>Oluwaseun A.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Sallinen</surname><given-names>Hanne</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>1) Teva, funding for travel to conference2) Genzyme, funding for travel to conference</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>1) Helsinki University Hospital, Finland</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>1) Maire Taponen Foundation, Finland.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Yeh</surname><given-names>Shin-Joe</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Teddy Y.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Ferrigno</surname><given-names>Marc</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Houben</surname><given-names>Rik</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Schreuder</surname><given-names>Floris H.B.M.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Perry</surname><given-names>Luke A.</given-names></name><degrees>BSc</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Tanaka</surname><given-names>Jun</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Boulanger</surname><given-names>Marion</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Al-Shahi Salman</surname><given-names>Rustam</given-names></name><degrees>FRCP Edin</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>(1) Cochrane Stroke Group, editor, 2009-present(2) Evidence-based Preclinical Medicine, senior editor, 2014-present(3) Trials, senior editor, 2016-present</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>UK Medical Research Council senior clinical fellowship (G1002605), 2011-2016. British Heart Foundation travel fellowship (FS/13/72/30531), 2013-2014.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Jäger</surname><given-names>Hans R.</given-names></name><degrees>MD, FRCR</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>I have received royalties for the following bookchapters:1.Saunders D, Jager HR, Murray A, Stevens J. In: GraingerRG, Allison DJ, Adams A, Dixon A, editors. Grainger andAllison Diagnostic Radiology: A Textbook of MedicalImaging. Churchill Livingstone</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>Sponsor: Biogen Activity: reader of MRI scans in context of largemulticenter drug trial in multiple sclerosisYear: 2005</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>2011-2014 NIHR Research for Patient Benefit Scheme UK(co-applicant) : ? 242,634 ?The Second European Carotid Surgery Trial (ECST-2): Pilotstudy?</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>University of Cambridge Fees for Examining PhD thesis 2008 and 2013</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>2010-2015 The Stroke Association / British HeartFoundation Joint Program Grant in Stroke (co-applicant): ? 939,718 ?Microbleeds and genetic risk factors to predictthe risk of intracranial haemorrhage in patients treatedwith anticoagulation following cardioembolic stroke due toatrial fibrillation?</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Ambler</surname><given-names>Gareth</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Journal of Colorectal Disease, Statistical Advisor, 2010-</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Shakeshaft</surname><given-names>Clare</given-names></name><degrees>MSc</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Yakushiji</surname><given-names>Yusuke</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Philip M.C.</given-names></name><degrees>MBChB, FRACP</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Staals</surname><given-names>Julie</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Cordonnier</surname><given-names>Charlotte</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Bayer, Medtronics, Daiichi Sankyo. Fees were paid to ADRINORD or Lille University Hospital research account. No personal funding.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>investigator in clinical trials for Pfizer, Astra-Zeneca. Fees were paid to ADRINORD or Lille University Hospital research account. No personal funding.</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Jeng</surname><given-names>Jiann-Shing</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Veltkamp</surname><given-names>Roland</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>(1) Bayer (2) Boehringer-Ingelheim (3) BMS/Pfizer (4)Daiichi Sankyo (5) Amgen (6) Sanofi</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>(1) Bayer (2) Boehringer Ingelheim (3) BMS/Pfizer (4) Sanofi Aventis (5) Roche (6) Apoplexmedicaltechnologies (7) St. Jude Medical (8) Daiichi Sankyo</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>(1) Morphosys (2) Daiichi Sankyo (3) Biogen</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>1) Bayer (2) Boehringer Ingelheim (3) BMS/Pfizer (4) Daiichi Sanky (Biogen)</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Deutsche Forschungsgemeinschaft DFG VE 196/3-1</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Else Kr?ner Fresenius Stiftung</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>Bayer</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Dowlatshahi</surname><given-names>Dar</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Bayer CanadaBMS</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Bayer, speaker honorariumBMS, speaker honorarium</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>International Journal of Stroke</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>Automatic detection of contrast extravasation on dynamic CTA.</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Octapharma unrestricted educational grant</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>CIHR</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Heart & Stroke Foundation of Canada</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Engelter</surname><given-names>Stefan T.</given-names></name><degrees>MD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Advisory boards for dabigatran (Boehringer-Ingelheim), andrivaroxaban (Bayer), and apixaban (BMS/Pfizer)Advisory board for Covidien</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Pharmaceutical Industry: financial support for participation on the European Stroke [Organisation]Conference (travel, accommodation) or for advisory board activities: Boehringer, Bayer, BMS/Pfizer, Covidien</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Member of the editorial board of STROKE (since 2006)</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>educational grant from Pfizer</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>(1)Swiss Heart Foundation.(2)Swiss National Science Foundation.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Parry-Jones</surname><given-names>Adrian R.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Meretoja</surname><given-names>Atte</given-names></name><degrees>MD, PhD, MSc</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>(1) Stryker, (2) Boehringer-Ingelheim, (3) Nestle, (4) Phagenesis</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>(1) Siemens, (2) Boehringer-Ingelheim, (3) Stryker</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>(1) International Journal of Stroke, editorial board member, 2013-, (2) European Stroke Journal, editorial board member, 2015-, (3) Stroke, editorial board member, 2016-</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>(1) Stryker, (2) Boehringer-Ingelheim, (3) Nestle, (4) Phagenesis</p></list-item></list></p><p><list list-type="order"><title>(1) Siemens, (2) Boehringer-Ingelheim, (3) Stryker</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>National Health and Medical Research Council, Australia, Chief Investigator, 2015-</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Werring</surname><given-names>David J.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Serving on scientific advisory boards for Allergan, Bayer, IXICO, and Amgen.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>Funding for speaking at an educational meeting by Bayer.</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>European Stroke Journal, Editorial Board Member, from 2016</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>Cerebral Microbleeds: Pathophysiology to Clinical Practice Cambridge University Press. Published 2011</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>Ixico Ltd. Provided input for a project on imaging of cerebral haemorrhage.</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>Dr Werring was UK PI for a clinical trial of ponezumab in cerebral amyloid angiopathy, which was sponsored and funded by Pfizer.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Clinical Senior Lectureship Award from Department of Health / Higher Education Funding Council For England2008-2013</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Grant funding from The Stroke Association / British Heart Foundation, and from the Rosetrees Trust.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><collab>And the CROMIS-2 collaborators</collab></contrib><aff>From the Stroke Research Center (D.W., C.S., D.J.W.) and Neuroradiological Academic Unit (H.R.J.), Department of Brain Repair and Rehabilitation, Institute of Neurology, and Department of Statistical Science (G.A.), UCL, London, UK; Stroke Center and Neurology (D.J.S., C.T., S.T.E.), University Hospital Basel, University of Basel, Switzerland; Ottawa Hospital Research Institute and University of Ottawa (G.B., D.D.), Canada; Department of Neurology (J.C.P., T.R.), Heidelberg University Hospital, Germany; Manchester Academic Health Sciences Center (O.A.S., A.R.P.-J.), Salford Royal NHS Foundation Trust, UK; Department of Neurology (H.S., A.M.), Helsinki University Hospital, Finland; Stroke Center & Department of Neurology (S.-J.Y., J.-S.J.), Department of Neurology, National Taiwan University Hospital, Taipei; Department of Medicine and neurology at the Royal Melbourne Hospital (T.Y.W., A.M.), University of Melbourne, Parkville, Australia; U1171–Degenerative & Vascular Cognitive Disorders (M.F., C.C.), Univ Lille, Inserm, CHU Lille, France; Department of Neurology (R.H., F.H.B.M.S., J.S.), Maastricht University Medical Center, the Netherlands; Department of Neurosciences (J.A.P., P.M.C.C.), Eastern Health, Melbourne, Australia; Division of Neurology, Department of Internal Medicine (J.T., Y.Y.), Saga University Faculty of Medicine, Japan; Division of Clinical Neurosciences (M.B., R.A.-S.S.), Center for Clinical Brain Sciences, School of Clinical Sciences, University of Edinburgh; Department of Stroke Medicine, Division of Brain Sciences (R.V.), Imperial College London, UK; and Neurorehabilitation Unit (S.T.E.), University of Basel and University Center for Medicine of Aging, Felix Platter Hospital, Switzerland.</aff></contrib-group><contrib-group><contrib contrib-type="collab"><collab>CROMIS-2 collaborators</collab></contrib><contrib contrib-type="collab"><name><surname>Shaw</surname><given-names>Louise</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Sword</surname><given-names>Jane</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Mohd</surname><given-names>Azlisham</given-names></name><degrees>MD Nor</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Sharma</surname><given-names>Pankaj</given-names></name><degrees>PhD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Kelly</surname><given-names>Deborah</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Harrington</surname><given-names>Frances</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Sprigg</surname><given-names>Nikola</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Randall</surname><given-names>Marc</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Smith</surname><given-names>Matthew</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Mahawish</surname><given-names>Karim</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Elmarim</surname><given-names>Abduelbaset</given-names></name><degrees>MD i</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Esisi</surname><given-names>Bernard</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Cullen</surname><given-names>Claire</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Nallasivam</surname><given-names>Arumug</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Price</surname><given-names>Christopher</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Barry</surname><given-names>Adrian</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Roffe</surname><given-names>Christine</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Coyle</surname><given-names>John</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Hassan</surname><given-names>Ahamad</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Lovelock</surname><given-names>Caroline</given-names></name><degrees>DPhil</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Birns</surname><given-names>Jonathan</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Cohen</surname><given-names>David</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Sekaran</surname><given-names>L</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Parry-Jones</surname><given-names>Adrian</given-names></name><degrees>PhD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Parry</surname><given-names>Anthea</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Hargroves</surname><given-names>David</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Proschel</surname><given-names>Harald</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Datta</surname><given-names>Prabel</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Darawil</surname><given-names>Khaled</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Manoj</surname><given-names>Aravindakshan</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Burn</surname><given-names>Mathew</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Patterson</surname><given-names>Chris</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Giallombardo</surname><given-names>Elio</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Smyth</surname><given-names>Nigel</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Mansoor</surname><given-names>Syed</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Anwar</surname><given-names>Ijaz</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Marsh</surname><given-names>Rachel</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Ispoglou</surname><given-names>Sissi</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Chadha</surname><given-names>Dinesh</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Prabhakaran</surname><given-names>Mathuri</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Meenakishundaram</surname><given-names>Sanjeevikumar</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>O'Connell</surname><given-names>Janice</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Scott</surname><given-names>Jon</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Krishnamurthy</surname><given-names>Vinodh</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Aghoram</surname><given-names>Prasanna</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>McCormick</surname><given-names>Michael</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>O’Mahony</surname><given-names>Paul</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Cooper</surname><given-names>Martin</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Choy</surname><given-names>Lillian</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Wilkinson</surname><given-names>Peter</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Leach</surname><given-names>Simon</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Caine</surname><given-names>Sarah</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Burger</surname><given-names>Ilse</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Gunathilagan</surname><given-names>Gunaratam</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Guyler</surname><given-names>Paul</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Emsley</surname><given-names>Hedley</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Davis</surname><given-names>Michelle</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Manawadu</surname><given-names>Dulka</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Pasco</surname><given-names>Kath</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Mamun</surname><given-names>Maam</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Luder</surname><given-names>Robert</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Sajid</surname><given-names>Mahmud</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Anwar</surname><given-names>Ijaz</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Okwera</surname><given-names>James</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Staals</surname><given-names>Julie</given-names></name><degrees>PhD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Warburton</surname><given-names>Elizabeth</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Saastamoinen</surname><given-names>Kari</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>England</surname><given-names>Timothy</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Putterill</surname><given-names>Janet</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Flossman</surname><given-names>Enrico</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Power</surname><given-names>Michael</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Dani</surname><given-names>Krishna</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Mangion</surname><given-names>David</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Corrigan</surname><given-names>John</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Suman</surname><given-names>Appu</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Corrigan</surname><given-names>John</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Lawrence</surname><given-names>Enas</given-names></name><degrees>MD</degrees><role>Dr</role></contrib><contrib contrib-type="collab"><name><surname>Vahidassr</surname><given-names>Djamil</given-names></name><degrees>MD</degrees><role>Dr</role></contrib></contrib-group><author-notes><corresp>Correspondence to David J. Werring: <email>d.werring@ucl.ac.uk</email></corresp><fn fn-type="other"><p>Coinvestigators are listed at <ext-link ext-link-type="uri" xlink:href="http://neurology.org/lookup/doi/10.1212/WNL.0000000000003886">Neurology.org</ext-link>.</p></fn><fn fn-type="financial-disclosure"><p>Go to <ext-link ext-link-type="uri" xlink:href="http://neurology.org/lookup/doi/10.1212/WNL.0000000000003886">Neurology.org</ext-link> for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was funded by British Heart Foundation.</p></fn></author-notes><pub-date pub-type="ppub"><day>02</day><month>5</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>02</day><month>5</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>88</volume><issue>18</issue><fpage>1693</fpage><lpage>1700</lpage><history><date date-type="received"><day>10</day><month>7</month><year>2016</year></date><date date-type="accepted"><day>18</day><month>1</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>American Academy of Neurology</copyright-holder><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License 4.0 (CC BY)</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="NEUROLOGY2016757070.pdf"></self-uri><abstract><sec><title>Objective:</title><p>In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) and vitamin K antagonist–associated ICH (VKA-ICH).</p></sec><sec><title>Methods:</title><p>We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours.</p></sec><sec><title>Results:</title><p>We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6–38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0–27.9) for VKA-ICH (<italic>p</italic> = 0.78). We did not find any difference between NOAC-ICH and VKA-ICH for all-cause mortality within 90 days (33% for NOAC-ICH vs 31% for VKA-ICH [<italic>p</italic> = 0.64]; adjusted Cox hazard ratio (for NOAC-ICH vs VKA-ICH) 0.93 [95% confidence interval (CI) 0.52–1.64] [<italic>p</italic> = 0.79]), the rate of HE (NOAC-ICH n = 29/48 [40%] vs VKA-ICH n = 93/140 [34%] [<italic>p</italic> = 0.45]), or functional outcome at hospital discharge (NOAC-ICH vs VKA-ICH odds ratio 0.47; 95% CI 0.18–1.19 [<italic>p</italic> = 0.11]).</p></sec><sec><title>Conclusions:</title><p>In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta><custom-meta><meta-name>special-property</meta-name><meta-value>podcast</meta-value></custom-meta><custom-meta><meta-name>special-property</meta-name><meta-value>ppage</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name><name sortKey="Basir, Ghazala" sort="Basir, Ghazala" uniqKey="Basir G" first="Ghazala" last="Basir">Ghazala Basir</name><name sortKey="Boulanger, Marion" sort="Boulanger, Marion" uniqKey="Boulanger M" first="Marion" last="Boulanger">Marion Boulanger</name><name sortKey="Choi, Philip M C" sort="Choi, Philip M C" uniqKey="Choi P" first="Philip M. C." last="Choi">Philip M. C. Choi</name><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name><name sortKey="Dowlatshahi, Dar" sort="Dowlatshahi, Dar" uniqKey="Dowlatshahi D" first="Dar" last="Dowlatshahi">Dar Dowlatshahi</name><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name><name sortKey="Ferrigno, Marc" sort="Ferrigno, Marc" uniqKey="Ferrigno M" first="Marc" last="Ferrigno">Marc Ferrigno</name><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name><name sortKey="Jeng, Jiann Shing" sort="Jeng, Jiann Shing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name><name sortKey="Perry, Luke A" sort="Perry, Luke A" uniqKey="Perry L" first="Luke A." last="Perry">Luke A. Perry</name><name sortKey="Purrucker, Jan C" sort="Purrucker, Jan C" uniqKey="Purrucker J" first="Jan C." last="Purrucker">Jan C. Purrucker</name><name sortKey="Rizos, Timolaos" sort="Rizos, Timolaos" uniqKey="Rizos T" first="Timolaos" last="Rizos">Timolaos Rizos</name><name sortKey="Sallinen, Hanne" sort="Sallinen, Hanne" uniqKey="Sallinen H" first="Hanne" last="Sallinen">Hanne Sallinen</name><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name><name sortKey="Seiffge, David J" sort="Seiffge, David J" uniqKey="Seiffge D" first="David J." last="Seiffge">David J. Seiffge</name><name sortKey="Shakeshaft, Clare" sort="Shakeshaft, Clare" uniqKey="Shakeshaft C" first="Clare" last="Shakeshaft">Clare Shakeshaft</name><name sortKey="Sobowale, Oluwaseun A" sort="Sobowale, Oluwaseun A" uniqKey="Sobowale O" first="Oluwaseun A." last="Sobowale">Oluwaseun A. Sobowale</name><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name><name sortKey="Tanaka, Jun" sort="Tanaka, Jun" uniqKey="Tanaka J" first="Jun" last="Tanaka">Jun Tanaka</name><name sortKey="Traenka, Christopher" sort="Traenka, Christopher" uniqKey="Traenka C" first="Christopher" last="Traenka">Christopher Traenka</name><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J." last="Werring">David J. Werring</name><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name><name sortKey="Wu, Teddy Y" sort="Wu, Teddy Y" uniqKey="Wu T" first="Teddy Y." last="Wu">Teddy Y. Wu</name><name sortKey="Yakushiji, Yusuke" sort="Yakushiji, Yusuke" uniqKey="Yakushiji Y" first="Yusuke" last="Yakushiji">Yusuke Yakushiji</name><name sortKey="Yeh, Shin Joe" sort="Yeh, Shin Joe" uniqKey="Yeh S" first="Shin-Joe" last="Yeh">Shin-Joe Yeh</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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