Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010
Identifieur interne : 005C98 ( PascalFrancis/Curation ); précédent : 005C97; suivant : 005C99Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010
Auteurs : A. N. Balamurugan [États-Unis] ; B. Naziruddin [États-Unis] ; A. Lockridge [États-Unis] ; M. Tiwari [États-Unis] ; G. Loganathan [États-Unis] ; M. Takita [États-Unis] ; S. Matsumoto [Japon] ; K. Papas [États-Unis] ; M. Trieger [États-Unis] ; H. Rainis [États-Unis] ; T. Kin [États-Unis] ; T. W. Kay [Australie] ; S. Wease [États-Unis] ; S. Messinger [États-Unis] ; C. Ricordi [États-Unis] ; R. Alejandro [États-Unis] ; J. Markmann [États-Unis] ; J. Kerr-Conti [France] ; M. R. Rickels [États-Unis] ; C. Liu [États-Unis] ; X. Zhang [États-Unis] ; P. Witkowski [États-Unis] ; A. Posselt [États-Unis] ; P. Maffi [Italie] ; A. Secchi [Italie] ; T. Berney [Suisse] ; P. J. O'Connell [Australie] ; B. J. Hering [États-Unis] ; F. B. Barton [États-Unis]Source :
- American journal of transplantation : (Print) [ 1600-6135 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme, Diabète, Santé publique.
English descriptors
- KwdEn :
Abstract
The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 103 IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</title>
<author><name sortKey="Balamurugan, A N" sort="Balamurugan, A N" uniqKey="Balamurugan A" first="A. N." last="Balamurugan">A. N. Balamurugan</name>
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<author><name sortKey="Naziruddin, B" sort="Naziruddin, B" uniqKey="Naziruddin B" first="B." last="Naziruddin">B. Naziruddin</name>
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<author><name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M." last="Tiwari">M. Tiwari</name>
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<author><name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G." last="Loganathan">G. Loganathan</name>
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<author><name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M." last="Takita">M. Takita</name>
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<author><name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S." last="Matsumoto">S. Matsumoto</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1>
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<s3>JPN</s3>
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<author><name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K." last="Papas">K. Papas</name>
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<author><name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M." last="Trieger">M. Trieger</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
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<author><name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H." last="Rainis">H. Rainis</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
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<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
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<author><name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T." last="Kin">T. Kin</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Clinical Islet Laboratory, University of Alberta</s1>
<s2>Edmonton, AB</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
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<author><name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T. W." last="Kay">T. W. Kay</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>St. Vincent's Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
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<country>Australie</country>
</affiliation>
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<author><name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S." last="Wease">S. Wease</name>
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<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
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</affiliation>
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<author><name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S." last="Messinger">S. Messinger</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Public Health Services, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
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<author><name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C." last="Ricordi">C. Ricordi</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
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</affiliation>
</author>
<author><name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R." last="Alejandro">R. Alejandro</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
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<author><name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J." last="Markmann">J. Markmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Surgery, Massachusetts General Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J." last="Kerr-Conti">J. Kerr-Conti</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Lille University Hospital</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
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<author><name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M. R." last="Rickels">M. R. Rickels</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Medicine, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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<author><name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C." last="Liu">C. Liu</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Surgery, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Feinberg School of Medicine, Northwestern University</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
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<country>États-Unis</country>
</affiliation>
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<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Surgery, University of Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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<author><name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A." last="Posselt">A. Posselt</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Surgery, University of California, San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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<author><name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P." last="Maffi">P. Maffi</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
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<country>Italie</country>
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<author><name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A." last="Secchi">A. Secchi</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
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<country>Italie</country>
</affiliation>
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<author><name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T." last="Berney">T. Berney</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Surgery, Geneva University Hospital</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
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<author><name sortKey="O Connell, P J" sort="O Connell, P J" uniqKey="O Connell P" first="P. J." last="O'Connell">P. J. O'Connell</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>27 aut.</sZ>
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<author><name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B. J." last="Hering">B. J. Hering</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>28 aut.</sZ>
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<country>États-Unis</country>
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<author><name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F. B." last="Barton">F. B. Barton</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
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<series><title level="j" type="main">American journal of transplantation : (Print)</title>
<title level="j" type="abbreviated">Am. j. transplant. : (Print)</title>
<idno type="ISSN">1600-6135</idno>
<imprint><date when="2014">2014</date>
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<seriesStmt><title level="j" type="main">American journal of transplantation : (Print)</title>
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<term>Characteristics</term>
<term>Diabetes mellitus</term>
<term>Graft</term>
<term>Homograft</term>
<term>Human</term>
<term>Langerhans islet</term>
<term>Public health</term>
<term>Register</term>
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<term>Ilot Langerhans</term>
<term>Caractéristiques</term>
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<term>Homme</term>
<term>Registre</term>
<term>Diabète</term>
<term>1999</term>
<term>Santé publique</term>
<term>2010</term>
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<front><div type="abstract" xml:lang="en">The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 10<sup>3 </sup>
IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.</div>
</front>
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<fA05><s2>14</s2>
</fA05>
<fA06><s2>11</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BALAMURUGAN (A. N.)</s1>
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<fA11 i1="16" i2="1"><s1>ALEJANDRO (R.)</s1>
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<fA11 i1="21" i2="1"><s1>ZHANG (X.)</s1>
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<fA11 i1="27" i2="1"><s1>O'CONNELL (P. J.)</s1>
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<fA11 i1="28" i2="1"><s1>HERING (B. J.)</s1>
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<fA11 i1="29" i2="1"><s1>BARTON (F. B.)</s1>
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<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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<fA14 i1="02"><s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1>
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<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="03"><s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1>
<s2>Tokushima</s2>
<s3>JPN</s3>
<sZ>7 aut.</sZ>
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<fA14 i1="04"><s1>Institute for Cellular Transplantation, University of Arizona</s1>
<s2>Tucson, AZ</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
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<fA14 i1="05"><s1>The EMMES Corporation</s1>
<s2>Rockville, MD</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>29 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Clinical Islet Laboratory, University of Alberta</s1>
<s2>Edmonton, AB</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>St. Vincent's Hospital</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
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<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Department of Surgery, Massachusetts General Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
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<fA14 i1="11"><s1>Lille University Hospital</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>18 aut.</sZ>
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<fA14 i1="12"><s1>Department of Medicine, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Department of Surgery, University of Pennsylvania</s1>
<s2>Philadelphia, PA</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Feinberg School of Medicine, Northwestern University</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Department of Surgery, University of Chicago</s1>
<s2>Chicago, IL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Department of Surgery, University of California, San Francisco</s1>
<s2>San Francisco, CA</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</fA14>
<fA14 i1="18"><s1>Department of Surgery, Geneva University Hospital</s1>
<s2>Geneva</s2>
<s3>CHE</s3>
<sZ>26 aut.</sZ>
</fA14>
<fA14 i1="19"><s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1>
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<sZ>27 aut.</sZ>
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<fA20><s1>2595-2606</s1>
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<fA61><s0>A</s0>
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<fA64 i1="01" i2="1"><s0>American journal of transplantation : (Print)</s0>
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</fA66>
<fC01 i1="01" l="ENG"><s0>The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 10<sup>3 </sup>
IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.</s0>
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<fC02 i1="01" i2="X"><s0>002B25</s0>
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<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Registre</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Register</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Registro</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Diabète</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Diabetes mellitus</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Diabetes</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>1999</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>1999</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>1999</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Santé publique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Public health</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>2010</s0>
<s4>INC</s4>
<s5>86</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pancréas endocrine</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Endocrine pancreas</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Páncreas endocrino</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>38</s5>
</fC07>
<fN21><s1>005</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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