Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010
Identifieur interne : 000155 ( PascalFrancis/Corpus ); précédent : 000154; suivant : 000156Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010
Auteurs : A. N. Balamurugan ; B. Naziruddin ; A. Lockridge ; M. Tiwari ; G. Loganathan ; M. Takita ; S. Matsumoto ; K. Papas ; M. Trieger ; H. Rainis ; T. Kin ; T. W. Kay ; S. Wease ; S. Messinger ; C. Ricordi ; R. Alejandro ; J. Markmann ; J. Kerr-Conti ; M. R. Rickels ; C. Liu ; X. Zhang ; P. Witkowski ; A. Posselt ; P. Maffi ; A. Secchi ; T. Berney ; P. J. O'Connell ; B. J. Hering ; F. B. BartonSource :
- American journal of transplantation : (Print) [ 1600-6135 ] ; 2014.
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English descriptors
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Abstract
The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 103 IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.
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Format Inist (serveur)
| NO : | PASCAL 15-0002622 INIST |
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| ET : | Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010 |
| AU : | BALAMURUGAN (A. N.); NAZIRUDDIN (B.); LOCKRIDGE (A.); TIWARI (M.); LOGANATHAN (G.); TAKITA (M.); MATSUMOTO (S.); PAPAS (K.); TRIEGER (M.); RAINIS (H.); KIN (T.); KAY (T. W.); WEASE (S.); MESSINGER (S.); RICORDI (C.); ALEJANDRO (R.); MARKMANN (J.); KERR-CONTI (J.); RICKELS (M. R.); LIU (C.); ZHANG (X.); WITKOWSKI (P.); POSSELT (A.); MAFFI (P.); SECCHI (A.); BERNEY (T.); O'CONNELL (P. J.); HERING (B. J.); BARTON (F. B.) |
| AF : | Schulze Diabetes Institute, Department of Surgery, University of Minnesota/Minneapolis, MN/Etats-Unis (1 aut., 3 aut., 4 aut., 5 aut., 28 aut.); Baylor Annette C. and Harold C. Simmons Transplant Institute/Dallas, TX/Etats-Unis (2 aut., 6 aut.); Research and Development Center, Otsuka Pharmaceutical Factory, Inc./Tokushima/Japon (7 aut.); Institute for Cellular Transplantation, University of Arizona/Tucson, AZ/Etats-Unis (8 aut.); The EMMES Corporation/Rockville, MD/Etats-Unis (9 aut., 10 aut., 13 aut., 29 aut.); Clinical Islet Laboratory, University of Alberta/Edmonton, AB/Etats-Unis (11 aut.); St. Vincent's Hospital/Melbourne/Australie (12 aut.); Department of Public Health Services, University of Miami/Miami, FL/Etats-Unis (14 aut.); Diabetes Research Institute, University of Miami/Miami, FL/Etats-Unis (15 aut., 16 aut.); Department of Surgery, Massachusetts General Hospital/Boston, MA/Etats-Unis (17 aut.); Lille University Hospital/Lille/France (18 aut.); Department of Medicine, University of Pennsylvania/Philadelphia, PA/Etats-Unis (19 aut.); Department of Surgery, University of Pennsylvania/Philadelphia, PA/Etats-Unis (20 aut.); Feinberg School of Medicine, Northwestern University/Chicago, IL/Etats-Unis (21 aut.); Department of Surgery, University of Chicago/Chicago, IL/Etats-Unis (22 aut.); Department of Surgery, University of California, San Francisco/San Francisco, CA/Etats-Unis (23 aut.); Vita-Salute, San Raffaele University/Milan/Italie (24 aut., 25 aut.); Department of Surgery, Geneva University Hospital/Geneva/Suisse (26 aut.); National Pancreas Transplant Unit, University of Sydney at Westmead Hospital/Sydney/Australie (27 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | American journal of transplantation : (Print); ISSN 1600-6135; Etats-Unis; Da. 2014; Vol. 14; No. 11; Pp. 2595-2606; Bibl. 58 ref. |
| LA : | Anglais |
| EA : | The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 103 IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period. |
| CC : | 002B25; 002B21E01A; 002B30A11 |
| FD : | Greffe; Ilot Langerhans; Caractéristiques; Homogreffe; Homme; Registre; Diabète; 1999; Santé publique; 2010 |
| FG : | Pancréas endocrine; Endocrinopathie |
| ED : | Graft; Langerhans islet; Characteristics; Homograft; Human; Register; Diabetes mellitus; 1999; Public health |
| EG : | Endocrine pancreas; Endocrinopathy |
| SD : | Injerto; Isla Langerhans; Características; Homoinjerto; Hombre; Registro; Diabetes; 1999; Salud pública |
| LO : | INIST-27587.354000502532940150 |
| ID : | 15-0002622 |
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Pascal:15-0002622Le document en format XML
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Simmons Transplant Institute</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lockridge, A" sort="Lockridge, A" uniqKey="Lockridge A" first="A." last="Lockridge">A. Lockridge</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M." last="Tiwari">M. Tiwari</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G." last="Loganathan">G. Loganathan</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M." last="Takita">M. Takita</name><affiliation><inist:fA14 i1="02"><s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S." last="Matsumoto">S. Matsumoto</name><affiliation><inist:fA14 i1="03"><s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1><s2>Tokushima</s2><s3>JPN</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K." last="Papas">K. Papas</name><affiliation><inist:fA14 i1="04"><s1>Institute for Cellular Transplantation, University of Arizona</s1><s2>Tucson, AZ</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M." last="Trieger">M. Trieger</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H." last="Rainis">H. Rainis</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T." last="Kin">T. Kin</name><affiliation><inist:fA14 i1="06"><s1>Clinical Islet Laboratory, University of Alberta</s1><s2>Edmonton, AB</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T. W." last="Kay">T. W. Kay</name><affiliation><inist:fA14 i1="07"><s1>St. Vincent's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S." last="Wease">S. Wease</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S." last="Messinger">S. Messinger</name><affiliation><inist:fA14 i1="08"><s1>Department of Public Health Services, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C." last="Ricordi">C. Ricordi</name><affiliation><inist:fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R." last="Alejandro">R. Alejandro</name><affiliation><inist:fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J." last="Markmann">J. Markmann</name><affiliation><inist:fA14 i1="10"><s1>Department of Surgery, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J." last="Kerr-Conti">J. Kerr-Conti</name><affiliation><inist:fA14 i1="11"><s1>Lille University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M. R." last="Rickels">M. R. Rickels</name><affiliation><inist:fA14 i1="12"><s1>Department of Medicine, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C." last="Liu">C. Liu</name><affiliation><inist:fA14 i1="13"><s1>Department of Surgery, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name><affiliation><inist:fA14 i1="14"><s1>Feinberg School of Medicine, Northwestern University</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P." last="Witkowski">P. Witkowski</name><affiliation><inist:fA14 i1="15"><s1>Department of Surgery, University of Chicago</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A." last="Posselt">A. Posselt</name><affiliation><inist:fA14 i1="16"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, CA</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P." last="Maffi">P. Maffi</name><affiliation><inist:fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A." last="Secchi">A. Secchi</name><affiliation><inist:fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T." last="Berney">T. Berney</name><affiliation><inist:fA14 i1="18"><s1>Department of Surgery, Geneva University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="O Connell, P J" sort="O Connell, P J" uniqKey="O Connell P" first="P. J." last="O'Connell">P. J. O'Connell</name><affiliation><inist:fA14 i1="19"><s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B. J." last="Hering">B. J. Hering</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F. B." last="Barton">F. B. Barton</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">15-0002622</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 15-0002622 INIST</idno><idno type="RBID">Pascal:15-0002622</idno><idno type="wicri:Area/PascalFrancis/Corpus">000155</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</title><author><name sortKey="Balamurugan, A N" sort="Balamurugan, A N" uniqKey="Balamurugan A" first="A. N." last="Balamurugan">A. N. Balamurugan</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Naziruddin, B" sort="Naziruddin, B" uniqKey="Naziruddin B" first="B." last="Naziruddin">B. Naziruddin</name><affiliation><inist:fA14 i1="02"><s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lockridge, A" sort="Lockridge, A" uniqKey="Lockridge A" first="A." last="Lockridge">A. Lockridge</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Tiwari, M" sort="Tiwari, M" uniqKey="Tiwari M" first="M." last="Tiwari">M. Tiwari</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Loganathan, G" sort="Loganathan, G" uniqKey="Loganathan G" first="G." last="Loganathan">G. Loganathan</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Takita, M" sort="Takita, M" uniqKey="Takita M" first="M." last="Takita">M. Takita</name><affiliation><inist:fA14 i1="02"><s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Matsumoto, S" sort="Matsumoto, S" uniqKey="Matsumoto S" first="S." last="Matsumoto">S. Matsumoto</name><affiliation><inist:fA14 i1="03"><s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1><s2>Tokushima</s2><s3>JPN</s3><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Papas, K" sort="Papas, K" uniqKey="Papas K" first="K." last="Papas">K. Papas</name><affiliation><inist:fA14 i1="04"><s1>Institute for Cellular Transplantation, University of Arizona</s1><s2>Tucson, AZ</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Trieger, M" sort="Trieger, M" uniqKey="Trieger M" first="M." last="Trieger">M. Trieger</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rainis, H" sort="Rainis, H" uniqKey="Rainis H" first="H." last="Rainis">H. Rainis</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kin, T" sort="Kin, T" uniqKey="Kin T" first="T." last="Kin">T. Kin</name><affiliation><inist:fA14 i1="06"><s1>Clinical Islet Laboratory, University of Alberta</s1><s2>Edmonton, AB</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kay, T W" sort="Kay, T W" uniqKey="Kay T" first="T. W." last="Kay">T. W. Kay</name><affiliation><inist:fA14 i1="07"><s1>St. Vincent's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wease, S" sort="Wease, S" uniqKey="Wease S" first="S." last="Wease">S. Wease</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Messinger, S" sort="Messinger, S" uniqKey="Messinger S" first="S." last="Messinger">S. Messinger</name><affiliation><inist:fA14 i1="08"><s1>Department of Public Health Services, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Ricordi, C" sort="Ricordi, C" uniqKey="Ricordi C" first="C." last="Ricordi">C. Ricordi</name><affiliation><inist:fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Alejandro, R" sort="Alejandro, R" uniqKey="Alejandro R" first="R." last="Alejandro">R. Alejandro</name><affiliation><inist:fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Markmann, J" sort="Markmann, J" uniqKey="Markmann J" first="J." last="Markmann">J. Markmann</name><affiliation><inist:fA14 i1="10"><s1>Department of Surgery, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kerr Conti, J" sort="Kerr Conti, J" uniqKey="Kerr Conti J" first="J." last="Kerr-Conti">J. Kerr-Conti</name><affiliation><inist:fA14 i1="11"><s1>Lille University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>18 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rickels, M R" sort="Rickels, M R" uniqKey="Rickels M" first="M. R." last="Rickels">M. R. Rickels</name><affiliation><inist:fA14 i1="12"><s1>Department of Medicine, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Liu, C" sort="Liu, C" uniqKey="Liu C" first="C." last="Liu">C. Liu</name><affiliation><inist:fA14 i1="13"><s1>Department of Surgery, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>20 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zhang, X" sort="Zhang, X" uniqKey="Zhang X" first="X." last="Zhang">X. Zhang</name><affiliation><inist:fA14 i1="14"><s1>Feinberg School of Medicine, Northwestern University</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>21 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Witkowski, P" sort="Witkowski, P" uniqKey="Witkowski P" first="P." last="Witkowski">P. Witkowski</name><affiliation><inist:fA14 i1="15"><s1>Department of Surgery, University of Chicago</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Posselt, A" sort="Posselt, A" uniqKey="Posselt A" first="A." last="Posselt">A. Posselt</name><affiliation><inist:fA14 i1="16"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, CA</s2><s3>USA</s3><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Maffi, P" sort="Maffi, P" uniqKey="Maffi P" first="P." last="Maffi">P. Maffi</name><affiliation><inist:fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Secchi, A" sort="Secchi, A" uniqKey="Secchi A" first="A." last="Secchi">A. Secchi</name><affiliation><inist:fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berney, T" sort="Berney, T" uniqKey="Berney T" first="T." last="Berney">T. Berney</name><affiliation><inist:fA14 i1="18"><s1>Department of Surgery, Geneva University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>26 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="O Connell, P J" sort="O Connell, P J" uniqKey="O Connell P" first="P. J." last="O'Connell">P. J. O'Connell</name><affiliation><inist:fA14 i1="19"><s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>27 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hering, B J" sort="Hering, B J" uniqKey="Hering B" first="B. J." last="Hering">B. J. Hering</name><affiliation><inist:fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Barton, F B" sort="Barton, F B" uniqKey="Barton F" first="F. B." last="Barton">F. B. Barton</name><affiliation><inist:fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">American journal of transplantation : (Print)</title><title level="j" type="abbreviated">Am. j. transplant. : (Print)</title><idno type="ISSN">1600-6135</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of transplantation : (Print)</title><title level="j" type="abbreviated">Am. j. transplant. : (Print)</title><idno type="ISSN">1600-6135</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1999</term><term>Characteristics</term><term>Diabetes mellitus</term><term>Graft</term><term>Homograft</term><term>Human</term><term>Langerhans islet</term><term>Public health</term><term>Register</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Greffe</term><term>Ilot Langerhans</term><term>Caractéristiques</term><term>Homogreffe</term><term>Homme</term><term>Registre</term><term>Diabète</term><term>1999</term><term>Santé publique</term><term>2010</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 10<sup>3 </sup>IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1600-6135</s0></fA01><fA03 i2="1"><s0>Am. j. transplant. : (Print)</s0></fA03><fA05><s2>14</s2></fA05><fA06><s2>11</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</s1></fA08><fA11 i1="01" i2="1"><s1>BALAMURUGAN (A. N.)</s1></fA11><fA11 i1="02" i2="1"><s1>NAZIRUDDIN (B.)</s1></fA11><fA11 i1="03" i2="1"><s1>LOCKRIDGE (A.)</s1></fA11><fA11 i1="04" i2="1"><s1>TIWARI (M.)</s1></fA11><fA11 i1="05" i2="1"><s1>LOGANATHAN (G.)</s1></fA11><fA11 i1="06" i2="1"><s1>TAKITA (M.)</s1></fA11><fA11 i1="07" i2="1"><s1>MATSUMOTO (S.)</s1></fA11><fA11 i1="08" i2="1"><s1>PAPAS (K.)</s1></fA11><fA11 i1="09" i2="1"><s1>TRIEGER (M.)</s1></fA11><fA11 i1="10" i2="1"><s1>RAINIS (H.)</s1></fA11><fA11 i1="11" i2="1"><s1>KIN (T.)</s1></fA11><fA11 i1="12" i2="1"><s1>KAY (T. W.)</s1></fA11><fA11 i1="13" i2="1"><s1>WEASE (S.)</s1></fA11><fA11 i1="14" i2="1"><s1>MESSINGER (S.)</s1></fA11><fA11 i1="15" i2="1"><s1>RICORDI (C.)</s1></fA11><fA11 i1="16" i2="1"><s1>ALEJANDRO (R.)</s1></fA11><fA11 i1="17" i2="1"><s1>MARKMANN (J.)</s1></fA11><fA11 i1="18" i2="1"><s1>KERR-CONTI (J.)</s1></fA11><fA11 i1="19" i2="1"><s1>RICKELS (M. R.)</s1></fA11><fA11 i1="20" i2="1"><s1>LIU (C.)</s1></fA11><fA11 i1="21" i2="1"><s1>ZHANG (X.)</s1></fA11><fA11 i1="22" i2="1"><s1>WITKOWSKI (P.)</s1></fA11><fA11 i1="23" i2="1"><s1>POSSELT (A.)</s1></fA11><fA11 i1="24" i2="1"><s1>MAFFI (P.)</s1></fA11><fA11 i1="25" i2="1"><s1>SECCHI (A.)</s1></fA11><fA11 i1="26" i2="1"><s1>BERNEY (T.)</s1></fA11><fA11 i1="27" i2="1"><s1>O'CONNELL (P. J.)</s1></fA11><fA11 i1="28" i2="1"><s1>HERING (B. J.)</s1></fA11><fA11 i1="29" i2="1"><s1>BARTON (F. B.)</s1></fA11><fA14 i1="01"><s1>Schulze Diabetes Institute, Department of Surgery, University of Minnesota</s1><s2>Minneapolis, MN</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>28 aut.</sZ></fA14><fA14 i1="02"><s1>Baylor Annette C. and Harold C. Simmons Transplant Institute</s1><s2>Dallas, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="03"><s1>Research and Development Center, Otsuka Pharmaceutical Factory, Inc.</s1><s2>Tokushima</s2><s3>JPN</s3><sZ>7 aut.</sZ></fA14><fA14 i1="04"><s1>Institute for Cellular Transplantation, University of Arizona</s1><s2>Tucson, AZ</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="05"><s1>The EMMES Corporation</s1><s2>Rockville, MD</s2><s3>USA</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>29 aut.</sZ></fA14><fA14 i1="06"><s1>Clinical Islet Laboratory, University of Alberta</s1><s2>Edmonton, AB</s2><s3>USA</s3><sZ>11 aut.</sZ></fA14><fA14 i1="07"><s1>St. Vincent's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>12 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Public Health Services, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="09"><s1>Diabetes Research Institute, University of Miami</s1><s2>Miami, FL</s2><s3>USA</s3><sZ>15 aut.</sZ><sZ>16 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Surgery, Massachusetts General Hospital</s1><s2>Boston, MA</s2><s3>USA</s3><sZ>17 aut.</sZ></fA14><fA14 i1="11"><s1>Lille University Hospital</s1><s2>Lille</s2><s3>FRA</s3><sZ>18 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Medicine, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>19 aut.</sZ></fA14><fA14 i1="13"><s1>Department of Surgery, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>20 aut.</sZ></fA14><fA14 i1="14"><s1>Feinberg School of Medicine, Northwestern University</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>21 aut.</sZ></fA14><fA14 i1="15"><s1>Department of Surgery, University of Chicago</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>22 aut.</sZ></fA14><fA14 i1="16"><s1>Department of Surgery, University of California, San Francisco</s1><s2>San Francisco, CA</s2><s3>USA</s3><sZ>23 aut.</sZ></fA14><fA14 i1="17"><s1>Vita-Salute, San Raffaele University</s1><s2>Milan</s2><s3>ITA</s3><sZ>24 aut.</sZ><sZ>25 aut.</sZ></fA14><fA14 i1="18"><s1>Department of Surgery, Geneva University Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>26 aut.</sZ></fA14><fA14 i1="19"><s1>National Pancreas Transplant Unit, University of Sydney at Westmead Hospital</s1><s2>Sydney</s2><s3>AUS</s3><sZ>27 aut.</sZ></fA14><fA20><s1>2595-2606</s1></fA20><fA21><s1>2014</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>27587</s2><s5>354000502532940150</s5></fA43><fA44><s0>0000</s0><s1>© 2015 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>58 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>15-0002622</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>American journal of transplantation : (Print)</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 10<sup>3 </sup>IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.</s0></fC01><fC02 i1="01" i2="X"><s0>002B25</s0></fC02><fC02 i1="02" i2="X"><s0>002B21E01A</s0></fC02><fC02 i1="03" i2="X"><s0>002B30A11</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Greffe</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Graft</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Injerto</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Ilot Langerhans</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Langerhans islet</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Isla Langerhans</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Caractéristiques</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Characteristics</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Características</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Homogreffe</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Homograft</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Homoinjerto</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Registre</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Register</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Registro</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Diabète</s0><s2>NM</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Diabetes mellitus</s0><s2>NM</s2><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Diabetes</s0><s2>NM</s2><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>1999</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>1999</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>1999</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Santé publique</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Public health</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Salud pública</s0><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>2010</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pancréas endocrine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Endocrine pancreas</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Páncreas endocrino</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Endocrinopathie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Endocrinopathy</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Endocrinopatía</s0><s5>38</s5></fC07><fN21><s1>005</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 15-0002622 INIST</NO><ET>Islet Product Characteristics and Factors Related to Successful Human Islet Transplantation From the Collaborative Islet Transplant Registry (CITR) 1999-2010</ET><AU>BALAMURUGAN (A. N.); NAZIRUDDIN (B.); LOCKRIDGE (A.); TIWARI (M.); LOGANATHAN (G.); TAKITA (M.); MATSUMOTO (S.); PAPAS (K.); TRIEGER (M.); RAINIS (H.); KIN (T.); KAY (T. W.); WEASE (S.); MESSINGER (S.); RICORDI (C.); ALEJANDRO (R.); MARKMANN (J.); KERR-CONTI (J.); RICKELS (M. R.); LIU (C.); ZHANG (X.); WITKOWSKI (P.); POSSELT (A.); MAFFI (P.); SECCHI (A.); BERNEY (T.); O'CONNELL (P. J.); HERING (B. J.); BARTON (F. B.)</AU><AF>Schulze Diabetes Institute, Department of Surgery, University of Minnesota/Minneapolis, MN/Etats-Unis (1 aut., 3 aut., 4 aut., 5 aut., 28 aut.); Baylor Annette C. and Harold C. Simmons Transplant Institute/Dallas, TX/Etats-Unis (2 aut., 6 aut.); Research and Development Center, Otsuka Pharmaceutical Factory, Inc./Tokushima/Japon (7 aut.); Institute for Cellular Transplantation, University of Arizona/Tucson, AZ/Etats-Unis (8 aut.); The EMMES Corporation/Rockville, MD/Etats-Unis (9 aut., 10 aut., 13 aut., 29 aut.); Clinical Islet Laboratory, University of Alberta/Edmonton, AB/Etats-Unis (11 aut.); St. Vincent's Hospital/Melbourne/Australie (12 aut.); Department of Public Health Services, University of Miami/Miami, FL/Etats-Unis (14 aut.); Diabetes Research Institute, University of Miami/Miami, FL/Etats-Unis (15 aut., 16 aut.); Department of Surgery, Massachusetts General Hospital/Boston, MA/Etats-Unis (17 aut.); Lille University Hospital/Lille/France (18 aut.); Department of Medicine, University of Pennsylvania/Philadelphia, PA/Etats-Unis (19 aut.); Department of Surgery, University of Pennsylvania/Philadelphia, PA/Etats-Unis (20 aut.); Feinberg School of Medicine, Northwestern University/Chicago, IL/Etats-Unis (21 aut.); Department of Surgery, University of Chicago/Chicago, IL/Etats-Unis (22 aut.); Department of Surgery, University of California, San Francisco/San Francisco, CA/Etats-Unis (23 aut.); Vita-Salute, San Raffaele University/Milan/Italie (24 aut., 25 aut.); Department of Surgery, Geneva University Hospital/Geneva/Suisse (26 aut.); National Pancreas Transplant Unit, University of Sydney at Westmead Hospital/Sydney/Australie (27 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>American journal of transplantation : (Print); ISSN 1600-6135; Etats-Unis; Da. 2014; Vol. 14; No. 11; Pp. 2595-2606; Bibl. 58 ref.</SO><LA>Anglais</LA><EA>The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p < 0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 × 10<sup>3 </sup>IEQ; p < 0.05). Islet purity and total number of β cells significantly improved over the study period (p < 0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.</EA><CC>002B25; 002B21E01A; 002B30A11</CC><FD>Greffe; Ilot Langerhans; Caractéristiques; Homogreffe; Homme; Registre; Diabète; 1999; Santé publique; 2010</FD><FG>Pancréas endocrine; Endocrinopathie</FG><ED>Graft; Langerhans islet; Characteristics; Homograft; Human; Register; Diabetes mellitus; 1999; Public health</ED><EG>Endocrine pancreas; Endocrinopathy</EG><SD>Injerto; Isla Langerhans; Características; Homoinjerto; Hombre; Registro; Diabetes; 1999; Salud pública</SD><LO>INIST-27587.354000502532940150</LO><ID>15-0002622</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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