A genome-wide association meta-analysis identifies new childhood obesity loci
Identifieur interne : 004B68 ( PascalFrancis/Curation ); précédent : 004B67; suivant : 004B69A genome-wide association meta-analysis identifies new childhood obesity loci
Auteurs : Jonathan P. Bradfield [États-Unis] ; H. Rob Taal [Pays-Bas] ; Nicholas J. Timpson [Royaume-Uni] ; Andre Scherag [Allemagne] ; Cecile Lecoeur [France] ; Nicole M. Warrington [Australie] ; Elina Hypponen [Royaume-Uni] ; Claus Hoist [Danemark] ; Beatriz Valcarcel [Royaume-Uni] ; Elisabeth Thiering [Allemagne] ; Rany M. Salem [États-Unis] ; Fredrick R. Schumacher ; Diana L. Cousminer ; Patrick M. A. Sleiman [États-Unis] ; JIANHUA ZHAO ; Robert I. Berkowitz ; Karani S. Vimaleswaran [Royaume-Uni] ; Ivonne Jarick ; Craig E. Pennell [Australie] ; David M. Evans [Royaume-Uni] ; Beate St Pourcain [Royaume-Uni] ; Diane J. Berry [Royaume-Uni] ; Dennis O. Mook-Kanamori [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; Ralf J. P. Van Der Valk [Pays-Bas] ; Johan C. De Jongste [Pays-Bas] ; Dirkje S. Postma ; Dorret I. Boomsma ; W. James Gauderman ; Mohamed T. Hassanein ; Cecilia M. Lindgren [Pays-Bas] ; Reedik M Gi ; Colin A. G. Boreham ; Charlotte E. Neville ; Luis A. Moreno ; Paul Elliott [Royaume-Uni] ; Anneli Pouta ; Anna-Liisa Hartikainen ; MINGYAO LI ; Olli Raitakari ; Terho Lehtim Ki ; Johan G. Eriksson ; Aarno Palotie ; Jean Dallongeville ; Shikta Das [Royaume-Uni] ; Panos Deloukas ; George Mcmahon ; Susan M. Ring ; John P. Kemp [Royaume-Uni] ; Jessica L. Buxton ; Alexandra I. F. Blakemore ; Mariona Bustamante ; Monica Guxens ; Joel N. Hirschhorn [États-Unis] ; Matthew W. Gillman ; Eskil Kreiner-Moller ; Hans BisgaardSource :
- Nature genetics [ 1061-4036 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Association.
English descriptors
- KwdEn :
Abstract
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10-9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1.
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<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
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<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
</author>
<author><name sortKey="Boreham, Colin A G" sort="Boreham, Colin A G" uniqKey="Boreham C" first="Colin A. G." last="Boreham">Colin A. G. Boreham</name>
</author>
<author><name sortKey="Neville, Charlotte E" sort="Neville, Charlotte E" uniqKey="Neville C" first="Charlotte E." last="Neville">Charlotte E. Neville</name>
</author>
<author><name sortKey="Moreno, Luis A" sort="Moreno, Luis A" uniqKey="Moreno L" first="Luis A." last="Moreno">Luis A. Moreno</name>
</author>
<author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
</author>
<author><name sortKey="Mingyao Li" sort="Mingyao Li" uniqKey="Mingyao Li" last="Mingyao Li">MINGYAO LI</name>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
</author>
<author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
</author>
<author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name>
</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
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<s3>GBR</s3>
<sZ>9 aut.</sZ>
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<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
</author>
<author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name>
</author>
<author><name sortKey="Bustamante, Mariona" sort="Bustamante, Mariona" uniqKey="Bustamante M" first="Mariona" last="Bustamante">Mariona Bustamante</name>
</author>
<author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
</author>
<author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W." last="Gillman">Matthew W. Gillman</name>
</author>
<author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0235785</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0235785 INIST</idno>
<idno type="RBID">Pascal:12-0235785</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001347</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004B68</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A genome-wide association meta-analysis identifies new childhood obesity loci</title>
<author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Rob Taal, H" sort="Rob Taal, H" uniqKey="Rob Taal H" first="H." last="Rob Taal">H. Rob Taal</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="Andre" last="Scherag">Andre Scherag</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hypponen">Elina Hypponen</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Hoist, Claus" sort="Hoist, Claus" uniqKey="Hoist C" first="Claus" last="Hoist">Claus Hoist</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute of Preventive Medicine, Copenhagen University Hospital</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
</affiliation>
</author>
<author><name sortKey="Valcarcel, Beatriz" sort="Valcarcel, Beatriz" uniqKey="Valcarcel B" first="Beatriz" last="Valcarcel">Beatriz Valcarcel</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Salem, Rany M" sort="Salem, Rany M" uniqKey="Salem R" first="Rany M." last="Salem">Rany M. Salem</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name>
</author>
<author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name>
</author>
<author><name sortKey="Sleiman, Patrick M A" sort="Sleiman, Patrick M A" uniqKey="Sleiman P" first="Patrick M. A." last="Sleiman">Patrick M. A. Sleiman</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Jianhua Zhao" sort="Jianhua Zhao" uniqKey="Jianhua Zhao" last="Jianhua Zhao">JIANHUA ZHAO</name>
</author>
<author><name sortKey="Berkowitz, Robert I" sort="Berkowitz, Robert I" uniqKey="Berkowitz R" first="Robert I." last="Berkowitz">Robert I. Berkowitz</name>
</author>
<author><name sortKey="Vimaleswaran, Karani S" sort="Vimaleswaran, Karani S" uniqKey="Vimaleswaran K" first="Karani S." last="Vimaleswaran">Karani S. Vimaleswaran</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
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<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
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<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Van Der Valk, Ralf J P" sort="Van Der Valk, Ralf J P" uniqKey="Van Der Valk R" first="Ralf J. P." last="Van Der Valk">Ralf J. P. Van Der Valk</name>
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<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="De Jongste, Johan C" sort="De Jongste, Johan C" uniqKey="De Jongste J" first="Johan C." last="De Jongste">Johan C. De Jongste</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name>
</author>
<author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name>
</author>
<author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name>
</author>
<author><name sortKey="Hassanein, Mohamed T" sort="Hassanein, Mohamed T" uniqKey="Hassanein M" first="Mohamed T." last="Hassanein">Mohamed T. Hassanein</name>
</author>
<author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
</author>
<author><name sortKey="Boreham, Colin A G" sort="Boreham, Colin A G" uniqKey="Boreham C" first="Colin A. G." last="Boreham">Colin A. G. Boreham</name>
</author>
<author><name sortKey="Neville, Charlotte E" sort="Neville, Charlotte E" uniqKey="Neville C" first="Charlotte E." last="Neville">Charlotte E. Neville</name>
</author>
<author><name sortKey="Moreno, Luis A" sort="Moreno, Luis A" uniqKey="Moreno L" first="Luis A." last="Moreno">Luis A. Moreno</name>
</author>
<author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name>
</author>
<author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name>
</author>
<author><name sortKey="Mingyao Li" sort="Mingyao Li" uniqKey="Mingyao Li" last="Mingyao Li">MINGYAO LI</name>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
</author>
<author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
</author>
<author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name>
</author>
<author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
</author>
<author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name>
</author>
<author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name>
</author>
<author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name>
</author>
<author><name sortKey="Bustamante, Mariona" sort="Bustamante, Mariona" uniqKey="Bustamante M" first="Mariona" last="Bustamante">Mariona Bustamante</name>
</author>
<author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name>
</author>
<author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W." last="Gillman">Matthew W. Gillman</name>
</author>
<author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name>
</author>
<author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Identification</term>
<term>Locus</term>
<term>Metaanalysis</term>
<term>Nutritional status</term>
<term>Obesity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Association</term>
<term>Métaanalyse</term>
<term>Identification</term>
<term>Locus</term>
<term>Etat nutritionnel</term>
<term>Obésité</term>
<term>Echelle du génome</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-<sup>6</sup>
in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-<sup>9</sup>
; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10<sup>-9</sup>
; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI<sup>1</sup>
.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1061-4036</s0>
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<fA02 i1="01"><s0>NGENEC</s0>
</fA02>
<fA03 i2="1"><s0>Nat. genet.</s0>
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<fA05><s2>44</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>A genome-wide association meta-analysis identifies new childhood obesity loci</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BRADFIELD (Jonathan P.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>ROB TAAL (H.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>TIMPSON (Nicholas J.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>SCHERAG (Andre)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LECOEUR (Cecile)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>WARRINGTON (Nicole M.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>HYPPONEN (Elina)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>HOIST (Claus)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>VALCARCEL (Beatriz)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>THIERING (Elisabeth)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>SALEM (Rany M.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>SCHUMACHER (Fredrick R.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>COUSMINER (Diana L.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>SLEIMAN (Patrick M. A.)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>JIANHUA ZHAO</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>BERKOWITZ (Robert I.)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>VIMALESWARAN (Karani S.)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>JARICK (Ivonne)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>PENNELL (Craig E.)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>EVANS (David M.)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>ST POURCAIN (Beate)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>BERRY (Diane J.)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>MOOK-KANAMORI (Dennis O.)</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>HOFMAN (Albert)</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>RIVADENEIRA (Fernando)</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>UITTERLINDEN (Andre G.)</s1>
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<fA11 i1="27" i2="1"><s1>DUIJN (Cornelia M.van)</s1>
</fA11>
<fA11 i1="28" i2="1"><s1>VAN DER VALK (Ralf J.P.)</s1>
</fA11>
<fA11 i1="29" i2="1"><s1>DE JONGSTE (Johan C.)</s1>
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</fA11>
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</fA11>
<fA11 i1="32" i2="1"><s1>GAUDERMAN (W. James)</s1>
</fA11>
<fA11 i1="33" i2="1"><s1>HASSANEIN (Mohamed T.)</s1>
</fA11>
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</fA11>
<fA11 i1="35" i2="1"><s1>MÄGI (Reedik)</s1>
</fA11>
<fA11 i1="36" i2="1"><s1>BOREHAM (Colin A. G.)</s1>
</fA11>
<fA11 i1="37" i2="1"><s1>NEVILLE (Charlotte E.)</s1>
</fA11>
<fA11 i1="38" i2="1"><s1>MORENO (Luis A.)</s1>
</fA11>
<fA11 i1="39" i2="1"><s1>ELLIOTT (Paul)</s1>
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<fA11 i1="40" i2="1"><s1>POUTA (Anneli)</s1>
</fA11>
<fA11 i1="41" i2="1"><s1>HARTIKAINEN (Anna-Liisa)</s1>
</fA11>
<fA11 i1="42" i2="1"><s1>MINGYAO LI</s1>
</fA11>
<fA11 i1="43" i2="1"><s1>RAITAKARI (Olli)</s1>
</fA11>
<fA11 i1="44" i2="1"><s1>LEHTIMÄKI (Terho)</s1>
</fA11>
<fA11 i1="45" i2="1"><s1>ERIKSSON (Johan G.)</s1>
</fA11>
<fA11 i1="46" i2="1"><s1>PALOTIE (Aarno)</s1>
</fA11>
<fA11 i1="47" i2="1"><s1>DALLONGEVILLE (Jean)</s1>
</fA11>
<fA11 i1="48" i2="1"><s1>DAS (Shikta)</s1>
</fA11>
<fA11 i1="49" i2="1"><s1>DELOUKAS (Panos)</s1>
</fA11>
<fA11 i1="50" i2="1"><s1>MCMAHON (George)</s1>
</fA11>
<fA11 i1="51" i2="1"><s1>RING (Susan M.)</s1>
</fA11>
<fA11 i1="52" i2="1"><s1>KEMP (John P.)</s1>
</fA11>
<fA11 i1="53" i2="1"><s1>BUXTON (Jessica L.)</s1>
</fA11>
<fA11 i1="54" i2="1"><s1>BLAKEMORE (Alexandra I. F.)</s1>
</fA11>
<fA11 i1="55" i2="1"><s1>BUSTAMANTE (Mariona)</s1>
</fA11>
<fA11 i1="56" i2="1"><s1>GUXENS (Monica)</s1>
</fA11>
<fA11 i1="57" i2="1"><s1>HIRSCHHORN (Joel N.)</s1>
</fA11>
<fA11 i1="58" i2="1"><s1>GILLMAN (Matthew W.)</s1>
</fA11>
<fA11 i1="59" i2="1"><s1>KREINER-MOLLER (Eskil)</s1>
</fA11>
<fA11 i1="60" i2="1"><s1>BISGAARD (Hans)</s1>
</fA11>
<fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1>
<s2>Philadelphia, Pennsylvania</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>34 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>34 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>2 aut.</sZ>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>52 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1>
<s2>Western Australia</s2>
<s3>AUS</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Institute of Preventive Medicine, Copenhagen University Hospital</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>9 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>48 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I</s1>
<s2>Neuherberg</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</fA14>
<fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
<sZ>57 aut.</sZ>
</fA14>
<fA20><s1>526-531</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>22883</s2>
<s5>354000507712530080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>14 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0235785</s0>
</fA47>
<fA60><s1>P</s1>
<s3>CR</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Nature genetics</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-<sup>6</sup>
in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-<sup>9</sup>
; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10<sup>-9</sup>
; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI<sup>1</sup>
.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A07</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B22B</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Association</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Association</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Asociación</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Métaanalyse</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Metaanalysis</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Meta-análisis</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Identification</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Identification</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Identificación</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Locus</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Locus</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Locus</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Etat nutritionnel</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Nutritional status</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Estado nutricional</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Obésité</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Obesity</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Obesidad</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Echelle du génome</s0>
<s4>INC</s4>
<s5>88</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Trouble de la nutrition</s0>
<s5>19</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nutrition disorder</s0>
<s5>19</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Trastorno nutricíon</s0>
<s5>19</s5>
</fC07>
<fN21><s1>177</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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