A genome-wide association meta-analysis identifies new childhood obesity loci
Identifieur interne : 001347 ( PascalFrancis/Corpus ); précédent : 001346; suivant : 001348A genome-wide association meta-analysis identifies new childhood obesity loci
Auteurs : Jonathan P. Bradfield ; H. Rob Taal ; Nicholas J. Timpson ; Andre Scherag ; Cecile Lecoeur ; Nicole M. Warrington ; Elina Hypponen ; Claus Hoist ; Beatriz Valcarcel ; Elisabeth Thiering ; Rany M. Salem ; Fredrick R. Schumacher ; Diana L. Cousminer ; Patrick M. A. Sleiman ; JIANHUA ZHAO ; Robert I. Berkowitz ; Karani S. Vimaleswaran ; Ivonne Jarick ; Craig E. Pennell ; David M. Evans ; Beate St Pourcain ; Diane J. Berry ; Dennis O. Mook-Kanamori ; Albert Hofman ; Fernando Rivadeneira ; Andre G. Uitterlinden ; Cornelia M. Van Duijn ; Ralf J. P. Van Der Valk ; Johan C. De Jongste ; Dirkje S. Postma ; Dorret I. Boomsma ; W. James Gauderman ; Mohamed T. Hassanein ; Cecilia M. Lindgren ; Reedik M Gi ; Colin A. G. Boreham ; Charlotte E. Neville ; Luis A. Moreno ; Paul Elliott ; Anneli Pouta ; Anna-Liisa Hartikainen ; MINGYAO LI ; Olli Raitakari ; Terho Lehtim Ki ; Johan G. Eriksson ; Aarno Palotie ; Jean Dallongeville ; Shikta Das ; Panos Deloukas ; George Mcmahon ; Susan M. Ring ; John P. Kemp ; Jessica L. Buxton ; Alexandra I. F. Blakemore ; Mariona Bustamante ; Monica Guxens ; Joel N. Hirschhorn ; Matthew W. Gillman ; Eskil Kreiner-Moller ; Hans BisgaardSource :
- Nature genetics [ 1061-4036 ] ; 2012.
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Abstract
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10-9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1.
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| NO : | PASCAL 12-0235785 INIST |
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| ET : | A genome-wide association meta-analysis identifies new childhood obesity loci |
| AU : | BRADFIELD (Jonathan P.); ROB TAAL (H.); TIMPSON (Nicholas J.); SCHERAG (Andre); LECOEUR (Cecile); WARRINGTON (Nicole M.); HYPPONEN (Elina); HOIST (Claus); VALCARCEL (Beatriz); THIERING (Elisabeth); SALEM (Rany M.); SCHUMACHER (Fredrick R.); COUSMINER (Diana L.); SLEIMAN (Patrick M. A.); JIANHUA ZHAO; BERKOWITZ (Robert I.); VIMALESWARAN (Karani S.); JARICK (Ivonne); PENNELL (Craig E.); EVANS (David M.); ST POURCAIN (Beate); BERRY (Diane J.); MOOK-KANAMORI (Dennis O.); HOFMAN (Albert); RIVADENEIRA (Fernando); UITTERLINDEN (Andre G.); DUIJN (Cornelia M.van); VAN DER VALK (Ralf J.P.); DE JONGSTE (Johan C.); POSTMA (Dirkje S.); BOOMSMA (Dorret I.); GAUDERMAN (W. James); HASSANEIN (Mohamed T.); LINDGREN (Cecilia M.); MÄGI (Reedik); BOREHAM (Colin A. G.); NEVILLE (Charlotte E.); MORENO (Luis A.); ELLIOTT (Paul); POUTA (Anneli); HARTIKAINEN (Anna-Liisa); MINGYAO LI; RAITAKARI (Olli); LEHTIMÄKI (Terho); ERIKSSON (Johan G.); PALOTIE (Aarno); DALLONGEVILLE (Jean); DAS (Shikta); DELOUKAS (Panos); MCMAHON (George); RING (Susan M.); KEMP (John P.); BUXTON (Jessica L.); BLAKEMORE (Alexandra I. F.); BUSTAMANTE (Mariona); GUXENS (Monica); HIRSCHHORN (Joel N.); GILLMAN (Matthew W.); KREINER-MOLLER (Eskil); BISGAARD (Hans) |
| AF : | Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia/Philadelphia, Pennsylvania/Etats-Unis (1 aut., 14 aut.); The Generation R Study Group, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 23 aut., 24 aut., 28 aut., 29 aut., 34 aut.); Department of Epidemiology, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 23 aut., 24 aut., 25 aut., 26 aut., 27 aut., 34 aut.); Department of Pediatrics, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 23 aut.); The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol/Bristol/Royaume-Uni (3 aut., 20 aut., 21 aut., 52 aut.); Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen/Essen/Allemagne (4 aut.); Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute/Lille/France (5 aut.); School of Women's and Infants' Health, University of Western Australia, Perth/Western Australia/Australie (6 aut., 19 aut.); Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health/London/Royaume-Uni (7 aut., 17 aut., 22 aut.); Institute of Preventive Medicine, Copenhagen University Hospital/Copenhagen/Danemark (8 aut.); Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London/London/Royaume-Uni (9 aut., 39 aut., 48 aut.); Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I/Neuherberg/Allemagne (10 aut.); Division of Genetics, Children's Hospital/Boston, Massachusetts/Etats-Unis (11 aut., 57 aut.); Division of Endocrinology, Children's Hospital/Boston, Massachusetts/Etats-Unis (11 aut., 57 aut.); Program in Genomics, Children's Hospital/Boston, Massachusetts/Etats-Unis (11 aut., 57 aut.); Metabolism Program, Broad Institute/Cambridge, Massachusetts/Etats-Unis (11 aut., 57 aut.); Program in Medical and Population Genetics, Broad Institute/Cambridge, Massachusetts/Etats-Unis (11 aut., 57 aut.) |
| DT : | Publication en série; Correspondance, lettre; Niveau analytique |
| SO : | Nature genetics; ISSN 1061-4036; Coden NGENEC; Etats-Unis; Da. 2012; Vol. 44; No. 5; Pp. 526-531; Bibl. 14 ref. |
| LA : | Anglais |
| EA : | Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10-9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI1. |
| CC : | 002A07; 002B22B |
| FD : | Association; Métaanalyse; Identification; Locus; Etat nutritionnel; Obésité; Echelle du génome |
| FG : | Trouble de la nutrition |
| ED : | Association; Metaanalysis; Identification; Locus; Nutritional status; Obesity |
| EG : | Nutrition disorder |
| SD : | Asociación; Meta-análisis; Identificación; Locus; Estado nutricional; Obesidad |
| LO : | INIST-22883.354000507712530080 |
| ID : | 12-0235785 |
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Pascal:12-0235785Le document en format XML
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Van Der Valk</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="De Jongste, Johan C" sort="De Jongste, Johan C" uniqKey="De Jongste J" first="Johan C." last="De Jongste">Johan C. De Jongste</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name></author><author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name></author><author><name sortKey="Hassanein, Mohamed T" sort="Hassanein, Mohamed T" uniqKey="Hassanein M" first="Mohamed T." last="Hassanein">Mohamed T. Hassanein</name></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name></author><author><name sortKey="Boreham, Colin A G" sort="Boreham, Colin A G" uniqKey="Boreham C" first="Colin A. G." last="Boreham">Colin A. G. Boreham</name></author><author><name sortKey="Neville, Charlotte E" sort="Neville, Charlotte E" uniqKey="Neville C" first="Charlotte E." last="Neville">Charlotte E. Neville</name></author><author><name sortKey="Moreno, Luis A" sort="Moreno, Luis A" uniqKey="Moreno L" first="Luis A." last="Moreno">Luis A. Moreno</name></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>39 aut.</sZ><sZ>48 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></author><author><name sortKey="Mingyao Li" sort="Mingyao Li" uniqKey="Mingyao Li" last="Mingyao Li">MINGYAO LI</name></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name></author><author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name></author><author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name><affiliation><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>39 aut.</sZ><sZ>48 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>52 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name></author><author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name></author><author><name sortKey="Bustamante, Mariona" sort="Bustamante, Mariona" uniqKey="Bustamante M" first="Mariona" last="Bustamante">Mariona Bustamante</name></author><author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W." last="Gillman">Matthew W. Gillman</name></author><author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name></author><author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0235785</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0235785 INIST</idno><idno type="RBID">Pascal:12-0235785</idno><idno type="wicri:Area/PascalFrancis/Corpus">001347</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A genome-wide association meta-analysis identifies new childhood obesity loci</title><author><name sortKey="Bradfield, Jonathan P" sort="Bradfield, Jonathan P" uniqKey="Bradfield J" first="Jonathan P." last="Bradfield">Jonathan P. Bradfield</name><affiliation><inist:fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rob Taal, H" sort="Rob Taal, H" uniqKey="Rob Taal H" first="H." last="Rob Taal">H. Rob Taal</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name><affiliation><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>52 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Scherag, Andre" sort="Scherag, Andre" uniqKey="Scherag A" first="Andre" last="Scherag">Andre Scherag</name><affiliation><inist:fA14 i1="06"><s1>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name><affiliation><inist:fA14 i1="07"><s1>Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute</s1><s2>Lille</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name><affiliation><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1><s2>Western Australia</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hypponen">Elina Hypponen</name><affiliation><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hoist, Claus" sort="Hoist, Claus" uniqKey="Hoist C" first="Claus" last="Hoist">Claus Hoist</name><affiliation><inist:fA14 i1="10"><s1>Institute of Preventive Medicine, Copenhagen University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Valcarcel, Beatriz" sort="Valcarcel, Beatriz" uniqKey="Valcarcel B" first="Beatriz" last="Valcarcel">Beatriz Valcarcel</name><affiliation><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>39 aut.</sZ><sZ>48 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Thiering, Elisabeth" sort="Thiering, Elisabeth" uniqKey="Thiering E" first="Elisabeth" last="Thiering">Elisabeth Thiering</name><affiliation><inist:fA14 i1="12"><s1>Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Salem, Rany M" sort="Salem, Rany M" uniqKey="Salem R" first="Rany M." last="Salem">Rany M. Salem</name><affiliation><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R." last="Schumacher">Fredrick R. Schumacher</name></author><author><name sortKey="Cousminer, Diana L" sort="Cousminer, Diana L" uniqKey="Cousminer D" first="Diana L." last="Cousminer">Diana L. Cousminer</name></author><author><name sortKey="Sleiman, Patrick M A" sort="Sleiman, Patrick M A" uniqKey="Sleiman P" first="Patrick M. A." last="Sleiman">Patrick M. A. Sleiman</name><affiliation><inist:fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jianhua Zhao" sort="Jianhua Zhao" uniqKey="Jianhua Zhao" last="Jianhua Zhao">JIANHUA ZHAO</name></author><author><name sortKey="Berkowitz, Robert I" sort="Berkowitz, Robert I" uniqKey="Berkowitz R" first="Robert I." last="Berkowitz">Robert I. Berkowitz</name></author><author><name sortKey="Vimaleswaran, Karani S" sort="Vimaleswaran, Karani S" uniqKey="Vimaleswaran K" first="Karani S." last="Vimaleswaran">Karani S. Vimaleswaran</name><affiliation><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jarick, Ivonne" sort="Jarick, Ivonne" uniqKey="Jarick I" first="Ivonne" last="Jarick">Ivonne Jarick</name></author><author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name><affiliation><inist:fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1><s2>Western Australia</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name><affiliation><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>52 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="St Pourcain, Beate" sort="St Pourcain, Beate" uniqKey="St Pourcain B" first="Beate" last="St Pourcain">Beate St Pourcain</name><affiliation><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>52 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berry, Diane J" sort="Berry, Diane J" uniqKey="Berry D" first="Diane J." last="Berry">Diane J. Berry</name><affiliation><inist:fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O." last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Duijn, Cornelia M Van" sort="Duijn, Cornelia M Van" uniqKey="Duijn C" first="Cornelia M. Van" last="Duijn">Cornelia M. Van Duijn</name><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Van Der Valk, Ralf J P" sort="Van Der Valk, Ralf J P" uniqKey="Van Der Valk R" first="Ralf J. P." last="Van Der Valk">Ralf J. P. Van Der Valk</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="De Jongste, Johan C" sort="De Jongste, Johan C" uniqKey="De Jongste J" first="Johan C." last="De Jongste">Johan C. De Jongste</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Postma, Dirkje S" sort="Postma, Dirkje S" uniqKey="Postma D" first="Dirkje S." last="Postma">Dirkje S. Postma</name></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I." last="Boomsma">Dorret I. Boomsma</name></author><author><name sortKey="Gauderman, W James" sort="Gauderman, W James" uniqKey="Gauderman W" first="W. James" last="Gauderman">W. James Gauderman</name></author><author><name sortKey="Hassanein, Mohamed T" sort="Hassanein, Mohamed T" uniqKey="Hassanein M" first="Mohamed T." last="Hassanein">Mohamed T. Hassanein</name></author><author><name sortKey="Lindgren, Cecilia M" sort="Lindgren, Cecilia M" uniqKey="Lindgren C" first="Cecilia M." last="Lindgren">Cecilia M. Lindgren</name><affiliation><inist:fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name></author><author><name sortKey="Boreham, Colin A G" sort="Boreham, Colin A G" uniqKey="Boreham C" first="Colin A. G." last="Boreham">Colin A. G. Boreham</name></author><author><name sortKey="Neville, Charlotte E" sort="Neville, Charlotte E" uniqKey="Neville C" first="Charlotte E." last="Neville">Charlotte E. Neville</name></author><author><name sortKey="Moreno, Luis A" sort="Moreno, Luis A" uniqKey="Moreno L" first="Luis A." last="Moreno">Luis A. Moreno</name></author><author><name sortKey="Elliott, Paul" sort="Elliott, Paul" uniqKey="Elliott P" first="Paul" last="Elliott">Paul Elliott</name><affiliation><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>39 aut.</sZ><sZ>48 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Pouta, Anneli" sort="Pouta, Anneli" uniqKey="Pouta A" first="Anneli" last="Pouta">Anneli Pouta</name></author><author><name sortKey="Hartikainen, Anna Liisa" sort="Hartikainen, Anna Liisa" uniqKey="Hartikainen A" first="Anna-Liisa" last="Hartikainen">Anna-Liisa Hartikainen</name></author><author><name sortKey="Mingyao Li" sort="Mingyao Li" uniqKey="Mingyao Li" last="Mingyao Li">MINGYAO LI</name></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G." last="Eriksson">Johan G. Eriksson</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name></author><author><name sortKey="Dallongeville, Jean" sort="Dallongeville, Jean" uniqKey="Dallongeville J" first="Jean" last="Dallongeville">Jean Dallongeville</name></author><author><name sortKey="Das, Shikta" sort="Das, Shikta" uniqKey="Das S" first="Shikta" last="Das">Shikta Das</name><affiliation><inist:fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>39 aut.</sZ><sZ>48 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name></author><author><name sortKey="Mcmahon, George" sort="Mcmahon, George" uniqKey="Mcmahon G" first="George" last="Mcmahon">George Mcmahon</name></author><author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name></author><author><name sortKey="Kemp, John P" sort="Kemp, John P" uniqKey="Kemp J" first="John P." last="Kemp">John P. Kemp</name><affiliation><inist:fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>52 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Buxton, Jessica L" sort="Buxton, Jessica L" uniqKey="Buxton J" first="Jessica L." last="Buxton">Jessica L. Buxton</name></author><author><name sortKey="Blakemore, Alexandra I F" sort="Blakemore, Alexandra I F" uniqKey="Blakemore A" first="Alexandra I. F." last="Blakemore">Alexandra I. F. Blakemore</name></author><author><name sortKey="Bustamante, Mariona" sort="Bustamante, Mariona" uniqKey="Bustamante M" first="Mariona" last="Bustamante">Mariona Bustamante</name></author><author><name sortKey="Guxens, Monica" sort="Guxens, Monica" uniqKey="Guxens M" first="Monica" last="Guxens">Monica Guxens</name></author><author><name sortKey="Hirschhorn, Joel N" sort="Hirschhorn, Joel N" uniqKey="Hirschhorn J" first="Joel N." last="Hirschhorn">Joel N. Hirschhorn</name><affiliation><inist:fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gillman, Matthew W" sort="Gillman, Matthew W" uniqKey="Gillman M" first="Matthew W." last="Gillman">Matthew W. Gillman</name></author><author><name sortKey="Kreiner Moller, Eskil" sort="Kreiner Moller, Eskil" uniqKey="Kreiner Moller E" first="Eskil" last="Kreiner-Moller">Eskil Kreiner-Moller</name></author><author><name sortKey="Bisgaard, Hans" sort="Bisgaard, Hans" uniqKey="Bisgaard H" first="Hans" last="Bisgaard">Hans Bisgaard</name></author></analytic><series><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Nature genetics</title><title level="j" type="abbreviated">Nat. genet.</title><idno type="ISSN">1061-4036</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Identification</term><term>Locus</term><term>Metaanalysis</term><term>Nutritional status</term><term>Obesity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Association</term><term>Métaanalyse</term><term>Identification</term><term>Locus</term><term>Etat nutritionnel</term><term>Obésité</term><term>Echelle du génome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-<sup>6</sup> in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-<sup>9</sup>; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10<sup>-9</sup>; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI<sup>1</sup>.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1061-4036</s0></fA01><fA02 i1="01"><s0>NGENEC</s0></fA02><fA03 i2="1"><s0>Nat. genet.</s0></fA03><fA05><s2>44</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>A genome-wide association meta-analysis identifies new childhood obesity loci</s1></fA08><fA11 i1="01" i2="1"><s1>BRADFIELD (Jonathan P.)</s1></fA11><fA11 i1="02" i2="1"><s1>ROB TAAL (H.)</s1></fA11><fA11 i1="03" i2="1"><s1>TIMPSON (Nicholas J.)</s1></fA11><fA11 i1="04" i2="1"><s1>SCHERAG (Andre)</s1></fA11><fA11 i1="05" i2="1"><s1>LECOEUR (Cecile)</s1></fA11><fA11 i1="06" i2="1"><s1>WARRINGTON (Nicole M.)</s1></fA11><fA11 i1="07" i2="1"><s1>HYPPONEN (Elina)</s1></fA11><fA11 i1="08" i2="1"><s1>HOIST (Claus)</s1></fA11><fA11 i1="09" i2="1"><s1>VALCARCEL (Beatriz)</s1></fA11><fA11 i1="10" i2="1"><s1>THIERING (Elisabeth)</s1></fA11><fA11 i1="11" i2="1"><s1>SALEM (Rany M.)</s1></fA11><fA11 i1="12" i2="1"><s1>SCHUMACHER (Fredrick R.)</s1></fA11><fA11 i1="13" i2="1"><s1>COUSMINER (Diana L.)</s1></fA11><fA11 i1="14" i2="1"><s1>SLEIMAN (Patrick M. A.)</s1></fA11><fA11 i1="15" i2="1"><s1>JIANHUA ZHAO</s1></fA11><fA11 i1="16" i2="1"><s1>BERKOWITZ (Robert I.)</s1></fA11><fA11 i1="17" i2="1"><s1>VIMALESWARAN (Karani S.)</s1></fA11><fA11 i1="18" i2="1"><s1>JARICK (Ivonne)</s1></fA11><fA11 i1="19" i2="1"><s1>PENNELL (Craig E.)</s1></fA11><fA11 i1="20" i2="1"><s1>EVANS (David M.)</s1></fA11><fA11 i1="21" i2="1"><s1>ST POURCAIN (Beate)</s1></fA11><fA11 i1="22" i2="1"><s1>BERRY (Diane J.)</s1></fA11><fA11 i1="23" i2="1"><s1>MOOK-KANAMORI (Dennis O.)</s1></fA11><fA11 i1="24" i2="1"><s1>HOFMAN (Albert)</s1></fA11><fA11 i1="25" i2="1"><s1>RIVADENEIRA (Fernando)</s1></fA11><fA11 i1="26" i2="1"><s1>UITTERLINDEN (Andre G.)</s1></fA11><fA11 i1="27" i2="1"><s1>DUIJN (Cornelia M.van)</s1></fA11><fA11 i1="28" i2="1"><s1>VAN DER VALK (Ralf J.P.)</s1></fA11><fA11 i1="29" i2="1"><s1>DE JONGSTE (Johan C.)</s1></fA11><fA11 i1="30" i2="1"><s1>POSTMA (Dirkje S.)</s1></fA11><fA11 i1="31" i2="1"><s1>BOOMSMA (Dorret I.)</s1></fA11><fA11 i1="32" i2="1"><s1>GAUDERMAN (W. James)</s1></fA11><fA11 i1="33" i2="1"><s1>HASSANEIN (Mohamed T.)</s1></fA11><fA11 i1="34" i2="1"><s1>LINDGREN (Cecilia M.)</s1></fA11><fA11 i1="35" i2="1"><s1>MÄGI (Reedik)</s1></fA11><fA11 i1="36" i2="1"><s1>BOREHAM (Colin A. G.)</s1></fA11><fA11 i1="37" i2="1"><s1>NEVILLE (Charlotte E.)</s1></fA11><fA11 i1="38" i2="1"><s1>MORENO (Luis A.)</s1></fA11><fA11 i1="39" i2="1"><s1>ELLIOTT (Paul)</s1></fA11><fA11 i1="40" i2="1"><s1>POUTA (Anneli)</s1></fA11><fA11 i1="41" i2="1"><s1>HARTIKAINEN (Anna-Liisa)</s1></fA11><fA11 i1="42" i2="1"><s1>MINGYAO LI</s1></fA11><fA11 i1="43" i2="1"><s1>RAITAKARI (Olli)</s1></fA11><fA11 i1="44" i2="1"><s1>LEHTIMÄKI (Terho)</s1></fA11><fA11 i1="45" i2="1"><s1>ERIKSSON (Johan G.)</s1></fA11><fA11 i1="46" i2="1"><s1>PALOTIE (Aarno)</s1></fA11><fA11 i1="47" i2="1"><s1>DALLONGEVILLE (Jean)</s1></fA11><fA11 i1="48" i2="1"><s1>DAS (Shikta)</s1></fA11><fA11 i1="49" i2="1"><s1>DELOUKAS (Panos)</s1></fA11><fA11 i1="50" i2="1"><s1>MCMAHON (George)</s1></fA11><fA11 i1="51" i2="1"><s1>RING (Susan M.)</s1></fA11><fA11 i1="52" i2="1"><s1>KEMP (John P.)</s1></fA11><fA11 i1="53" i2="1"><s1>BUXTON (Jessica L.)</s1></fA11><fA11 i1="54" i2="1"><s1>BLAKEMORE (Alexandra I. F.)</s1></fA11><fA11 i1="55" i2="1"><s1>BUSTAMANTE (Mariona)</s1></fA11><fA11 i1="56" i2="1"><s1>GUXENS (Monica)</s1></fA11><fA11 i1="57" i2="1"><s1>HIRSCHHORN (Joel N.)</s1></fA11><fA11 i1="58" i2="1"><s1>GILLMAN (Matthew W.)</s1></fA11><fA11 i1="59" i2="1"><s1>KREINER-MOLLER (Eskil)</s1></fA11><fA11 i1="60" i2="1"><s1>BISGAARD (Hans)</s1></fA11><fA14 i1="01"><s1>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="02"><s1>The Generation R Study Group, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>34 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Epidemiology, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ><sZ>24 aut.</sZ><sZ>25 aut.</sZ><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>34 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Pediatrics, Erasmus Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>23 aut.</sZ></fA14><fA14 i1="05"><s1>The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol</s1><s2>Bristol</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>52 aut.</sZ></fA14><fA14 i1="06"><s1>Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen</s1><s2>Essen</s2><s3>DEU</s3><sZ>4 aut.</sZ></fA14><fA14 i1="07"><s1>Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute</s1><s2>Lille</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="08"><s1>School of Women's and Infants' Health, University of Western Australia, Perth</s1><s2>Western Australia</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="09"><s1>Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>17 aut.</sZ><sZ>22 aut.</sZ></fA14><fA14 i1="10"><s1>Institute of Preventive Medicine, Copenhagen University Hospital</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>8 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ><sZ>39 aut.</sZ><sZ>48 aut.</sZ></fA14><fA14 i1="12"><s1>Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I</s1><s2>Neuherberg</s2><s3>DEU</s3><sZ>10 aut.</sZ></fA14><fA14 i1="13"><s1>Division of Genetics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></fA14><fA14 i1="14"><s1>Division of Endocrinology, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></fA14><fA14 i1="15"><s1>Program in Genomics, Children's Hospital</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></fA14><fA14 i1="16"><s1>Metabolism Program, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></fA14><fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>11 aut.</sZ><sZ>57 aut.</sZ></fA14><fA20><s1>526-531</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>22883</s2><s5>354000507712530080</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>14 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0235785</s0></fA47><fA60><s1>P</s1><s3>CR</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Nature genetics</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-<sup>6</sup> in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-<sup>9</sup>; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10<sup>-9</sup>; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI<sup>1</sup>.</s0></fC01><fC02 i1="01" i2="X"><s0>002A07</s0></fC02><fC02 i1="02" i2="X"><s0>002B22B</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Association</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Association</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Asociación</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Métaanalyse</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Metaanalysis</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Meta-análisis</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Identification</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Identification</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Identificación</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Locus</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Locus</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Locus</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Etat nutritionnel</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Nutritional status</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Estado nutricional</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Obésité</s0><s5>14</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Obesity</s0><s5>14</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Obesidad</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Echelle du génome</s0><s4>INC</s4><s5>88</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Trouble de la nutrition</s0><s5>19</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nutrition disorder</s0><s5>19</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Trastorno nutricíon</s0><s5>19</s5></fC07><fN21><s1>177</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0235785 INIST</NO><ET>A genome-wide association meta-analysis identifies new childhood obesity loci</ET><AU>BRADFIELD (Jonathan P.); ROB TAAL (H.); TIMPSON (Nicholas J.); SCHERAG (Andre); LECOEUR (Cecile); WARRINGTON (Nicole M.); HYPPONEN (Elina); HOIST (Claus); VALCARCEL (Beatriz); THIERING (Elisabeth); SALEM (Rany M.); SCHUMACHER (Fredrick R.); COUSMINER (Diana L.); SLEIMAN (Patrick M. A.); JIANHUA ZHAO; BERKOWITZ (Robert I.); VIMALESWARAN (Karani S.); JARICK (Ivonne); PENNELL (Craig E.); EVANS (David M.); ST POURCAIN (Beate); BERRY (Diane J.); MOOK-KANAMORI (Dennis O.); HOFMAN (Albert); RIVADENEIRA (Fernando); UITTERLINDEN (Andre G.); DUIJN (Cornelia M.van); VAN DER VALK (Ralf J.P.); DE JONGSTE (Johan C.); POSTMA (Dirkje S.); BOOMSMA (Dorret I.); GAUDERMAN (W. James); HASSANEIN (Mohamed T.); LINDGREN (Cecilia M.); MÄGI (Reedik); BOREHAM (Colin A. G.); NEVILLE (Charlotte E.); MORENO (Luis A.); ELLIOTT (Paul); POUTA (Anneli); HARTIKAINEN (Anna-Liisa); MINGYAO LI; RAITAKARI (Olli); LEHTIMÄKI (Terho); ERIKSSON (Johan G.); PALOTIE (Aarno); DALLONGEVILLE (Jean); DAS (Shikta); DELOUKAS (Panos); MCMAHON (George); RING (Susan M.); KEMP (John P.); BUXTON (Jessica L.); BLAKEMORE (Alexandra I. F.); BUSTAMANTE (Mariona); GUXENS (Monica); HIRSCHHORN (Joel N.); GILLMAN (Matthew W.); KREINER-MOLLER (Eskil); BISGAARD (Hans)</AU><AF>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia/Philadelphia, Pennsylvania/Etats-Unis (1 aut., 14 aut.); The Generation R Study Group, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 23 aut., 24 aut., 28 aut., 29 aut., 34 aut.); Department of Epidemiology, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 23 aut., 24 aut., 25 aut., 26 aut., 27 aut., 34 aut.); Department of Pediatrics, Erasmus Medical Center/Rotterdam/Pays-Bas (2 aut., 23 aut.); The Medical Research Council (MRC) Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol/Bristol/Royaume-Uni (3 aut., 20 aut., 21 aut., 52 aut.); Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen/Essen/Allemagne (4 aut.); Centre National de la Recherche Scientifique (CNRS) 8199, Universite Lille Nord de France, Pasteur Institute/Lille/France (5 aut.); School of Women's and Infants' Health, University of Western Australia, Perth/Western Australia/Australie (6 aut., 19 aut.); Centre for Paediatric Epidemiology and Biostatistics, MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health/London/Royaume-Uni (7 aut., 17 aut., 22 aut.); Institute of Preventive Medicine, Copenhagen University Hospital/Copenhagen/Danemark (8 aut.); Department of Epidemiology and Biostatistics, MRC-Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Faculty of Medicine, Imperial College London/London/Royaume-Uni (9 aut., 39 aut., 48 aut.); Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology I/Neuherberg/Allemagne (10 aut.); Division of Genetics, Children's Hospital/Boston, Massachusetts/Etats-Unis (11 aut., 57 aut.); Division of Endocrinology, Children's Hospital/Boston, Massachusetts/Etats-Unis (11 aut., 57 aut.); Program in Genomics, Children's Hospital/Boston, Massachusetts/Etats-Unis (11 aut., 57 aut.); Metabolism Program, Broad Institute/Cambridge, Massachusetts/Etats-Unis (11 aut., 57 aut.); Program in Medical and Population Genetics, Broad Institute/Cambridge, Massachusetts/Etats-Unis (11 aut., 57 aut.)</AF><DT>Publication en série; Correspondance, lettre; Niveau analytique</DT><SO>Nature genetics; ISSN 1061-4036; Coden NGENEC; Etats-Unis; Da. 2012; Vol. 44; No. 5; Pp. 526-531; Bibl. 14 ref.</SO><LA>Anglais</LA><EA>Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10-<sup>6</sup> in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 x 10-<sup>9</sup>; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 x 10<sup>-9</sup>; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI<sup>1</sup>.</EA><CC>002A07; 002B22B</CC><FD>Association; Métaanalyse; Identification; Locus; Etat nutritionnel; Obésité; Echelle du génome</FD><FG>Trouble de la nutrition</FG><ED>Association; Metaanalysis; Identification; Locus; Nutritional status; Obesity</ED><EG>Nutrition disorder</EG><SD>Asociación; Meta-análisis; Identificación; Locus; Estado nutricional; Obesidad</SD><LO>INIST-22883.354000507712530080</LO><ID>12-0235785</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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