Comparison of Histological Measures of Skin Photoaging
Identifieur interne : 004777 ( PascalFrancis/Curation ); précédent : 004776; suivant : 004778Comparison of Histological Measures of Skin Photoaging
Auteurs : M. C. Hughes [Royaume-Uni] ; C. Bredoux [France] ; F. Salas [France] ; D. Lombard [France] ; G. M. Strutton [Australie] ; A. Fourtanier [France] ; A. C. Green [Royaume-Uni]Source :
- Dermatology : (Basel) [ 1018-8665 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Australie.
English descriptors
- KwdEn :
Abstract
Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.
pA |
|
---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001732
Links to Exploration step
Pascal:12-0018800Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Comparison of Histological Measures of Skin Photoaging</title>
<author><name sortKey="Hughes, M C" sort="Hughes, M C" uniqKey="Hughes M" first="M. C." last="Hughes">M. C. Hughes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer and Populations Studies, Queensland Institute of Medical Research</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Bredoux, C" sort="Bredoux, C" uniqKey="Bredoux C" first="C." last="Bredoux">C. Bredoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Salas, F" sort="Salas, F" uniqKey="Salas F" first="F." last="Salas">F. Salas</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lombard, D" sort="Lombard, D" uniqKey="Lombard D" first="D." last="Lombard">D. Lombard</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Strutton, G M" sort="Strutton, G M" uniqKey="Strutton G" first="G. M." last="Strutton">G. M. Strutton</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Princess Alexandra Hospital</s1>
<s2>Brisbane, Qld.</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Fourtanier, A" sort="Fourtanier, A" uniqKey="Fourtanier A" first="A." last="Fourtanier">A. Fourtanier</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>L'Oréal Recherche</s1>
<s2>Clichy</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Green, A C" sort="Green, A C" uniqKey="Green A" first="A. C." last="Green">A. C. Green</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer and Populations Studies, Queensland Institute of Medical Research</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University of Manchester, Manchester Academic Health Sciences Centre</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0018800</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 12-0018800 INIST</idno>
<idno type="RBID">Pascal:12-0018800</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001732</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004777</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Comparison of Histological Measures of Skin Photoaging</title>
<author><name sortKey="Hughes, M C" sort="Hughes, M C" uniqKey="Hughes M" first="M. C." last="Hughes">M. C. Hughes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer and Populations Studies, Queensland Institute of Medical Research</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Bredoux, C" sort="Bredoux, C" uniqKey="Bredoux C" first="C." last="Bredoux">C. Bredoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Salas, F" sort="Salas, F" uniqKey="Salas F" first="F." last="Salas">F. Salas</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Lombard, D" sort="Lombard, D" uniqKey="Lombard D" first="D." last="Lombard">D. Lombard</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Strutton, G M" sort="Strutton, G M" uniqKey="Strutton G" first="G. M." last="Strutton">G. M. Strutton</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Princess Alexandra Hospital</s1>
<s2>Brisbane, Qld.</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Australie</country>
</affiliation>
</author>
<author><name sortKey="Fourtanier, A" sort="Fourtanier, A" uniqKey="Fourtanier A" first="A." last="Fourtanier">A. Fourtanier</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>L'Oréal Recherche</s1>
<s2>Clichy</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Green, A C" sort="Green, A C" uniqKey="Green A" first="A. C." last="Green">A. C. Green</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer and Populations Studies, Queensland Institute of Medical Research</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University of Manchester, Manchester Academic Health Sciences Centre</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Dermatology : (Basel)</title>
<title level="j" type="abbreviated">Dermatology : (Basel)</title>
<idno type="ISSN">1018-8665</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Dermatology : (Basel)</title>
<title level="j" type="abbreviated">Dermatology : (Basel)</title>
<idno type="ISSN">1018-8665</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Australia</term>
<term>Comparative study</term>
<term>Dermatology</term>
<term>Elastosis</term>
<term>Skin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Elastose</term>
<term>Etude comparative</term>
<term>Peau</term>
<term>Australie</term>
<term>Dermatologie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Australie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1018-8665</s0>
</fA01>
<fA03 i2="1"><s0>Dermatology : (Basel)</s0>
</fA03>
<fA05><s2>223</s2>
</fA05>
<fA06><s2>2</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Comparison of Histological Measures of Skin Photoaging</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>HUGHES (M. C.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BREDOUX (C.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>SALAS (F.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>LOMBARD (D.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>STRUTTON (G. M.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>FOURTANIER (A.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>GREEN (A. C.)</s1>
</fA11>
<fA14 i1="01"><s1>Cancer and Populations Studies, Queensland Institute of Medical Research</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Princess Alexandra Hospital</s1>
<s2>Brisbane, Qld.</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>L'Oréal Research and Innovation, Aulnay-sous-Bois</s1>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>L'Oréal Recherche</s1>
<s2>Clichy</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>University of Manchester, Manchester Academic Health Sciences Centre</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>140-151</s1>
</fA20>
<fA21><s1>2011</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>4530</s2>
<s5>354000507365380090</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>50 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0018800</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Dermatology : (Basel)</s0>
</fA64>
<fA66 i1="01"><s0>CHE</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B08</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B07</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Elastose</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Elastosis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Elastosis</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Peau</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Skin</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Piel</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Australie</s0>
<s2>NG</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Australia</s0>
<s2>NG</s2>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Australia</s0>
<s2>NG</s2>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Dermatologie</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Dermatology</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Dermatología</s0>
<s5>13</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Océanie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de la peau</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Skin disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Piel patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du tissu élastique</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Elastic tissue disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Tejido elástico patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>002</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004777 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 004777 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PascalFrancis |étape= Curation |type= RBID |clé= Pascal:12-0018800 |texte= Comparison of Histological Measures of Skin Photoaging }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |