AustralieFrV1, PascalFrancis, Curation, bibRecord, 004777

Comparison of Histological Measures of Skin Photoaging

Identifieur interne : 004777 ( PascalFrancis/Curation ); précédent : 004776; suivant : 004778

Comparison of Histological Measures of Skin Photoaging

Auteurs : M. C. Hughes [Royaume-Uni] ; C. Bredoux [France] ; F. Salas [France] ; D. Lombard [France] ; G. M. Strutton [Australie] ; A. Fourtanier [France] ; A. C. Green [Royaume-Uni]

Source :

Dermatology : (Basel) [ 1018-8665 ] ; 2011.

RBID : Pascal:12-0018800

Descripteurs français

Pascal (Inist)
- Elastose, Etude comparative, Peau, Australie, Dermatologie.
Wicri :
- geographic : Australie.

English descriptors

KwdEn :
- Australia, Comparative study, Dermatology, Elastosis, Skin.

Abstract

Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.

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A08	`01`	`1`	`ENG`	`@1 Comparison of Histological Measures of Skin Photoaging`
A11	`01`	`1`		`@1 HUGHES (M. C.)`
A11	`02`	`1`		`@1 BREDOUX (C.)`
A11	`03`	`1`		`@1 SALAS (F.)`
A11	`04`	`1`		`@1 LOMBARD (D.)`
A11	`05`	`1`		`@1 STRUTTON (G. M.)`
A11	`06`	`1`		`@1 FOURTANIER (A.)`
A11	`07`	`1`		`@1 GREEN (A. C.)`
A14	`01`			`@1 Cancer and Populations Studies, Queensland Institute of Medical Research @3 GBR @Z 1 aut. @Z 7 aut.`
A14	`02`			`@1 Princess Alexandra Hospital @2 Brisbane, Qld. @3 AUS @Z 5 aut.`
A14	`03`			`@1 L'Oréal Research and Innovation, Aulnay-sous-Bois @3 FRA @Z 2 aut. @Z 3 aut. @Z 4 aut.`
A14	`04`			`@1 L'Oréal Recherche @2 Clichy @3 FRA @Z 6 aut.`
A14	`05`			`@1 University of Manchester, Manchester Academic Health Sciences Centre @2 Manchester @3 GBR @Z 7 aut.`
A20				`@1 140-151`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 4530 @5 354000507365380090`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
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A64	`01`	`1`		`@0 Dermatology : (Basel)`
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C01	`01`		`ENG`	@0 Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.
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C03	`02`	`X`	`SPA`	`@0 Estudio comparativo @5 07`
C03	`03`	`X`	`FRE`	`@0 Peau @5 08`
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C07	`01`	`X`	`FRE`	`@0 Océanie @2 NG`
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C07	`01`	`X`	`SPA`	`@0 Oceania @2 NG`
C07	`02`	`X`	`FRE`	`@0 Pathologie de la peau @5 37`
C07	`02`	`X`	`ENG`	`@0 Skin disease @5 37`
C07	`02`	`X`	`SPA`	`@0 Piel patología @5 37`
C07	`03`	`X`	`FRE`	`@0 Pathologie du tissu élastique @5 38`
C07	`03`	`X`	`ENG`	`@0 Elastic tissue disease @5 38`
C07	`03`	`X`	`SPA`	`@0 Tejido elástico patología @5 38`
N21				`@1 002`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</div>
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<fC01 i1="01" l="ENG"><s0>Background: Dermal elastosis is considered the histological 'gold standard' for evaluation of skin photoaging, but the relation of the level of dermal elastosis to other histological indicators of photoaging is not clear. Objective: To investigate how various proposed histological measures of photoaging compare with the level of dermal elastosis. Methods: Prospective, community-based study in Southeast Queensland, Australia, among 89 participants aged 40-82 years. Quantitative histology was used to evaluate 8 biomarkers of photoaged skin, and associations between grades of dermal elastosis and each of the other 7 biomarkers were analysed using ordinal logistic regression models with proportional odds assumption, using histological grades of elastosis as the outcome. Results: Older age, male sex and high outdoor exposure levels were confirmed as predictors of high levels of dermal elastosis. After adjustment for age and sex, the only significant positive association with increasing elastosis grades was the proportion of p53-positive cells. Epidermal thickness, interdigitation index proportion of surface covered with melanin (% Fontana-Masson staining) and glycosaminoglycan content were not associated with elastosis in either crude or adjusted models. Conclusions: Among a range of suggested biomarkers of photoaged skin, only p53-positive cells appear to be strongly associated with the level of dermal elastosis.</s0>
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<s2>NG</s2>
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<fC07 i1="01" i2="X" l="SPA"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de la peau</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Skin disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Piel patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du  tissu élastique</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Elastic tissue disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Tejido elástico patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>002</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    PascalFrancis
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   |type=    RBID
   |clé=     Pascal:12-0018800
   |texte=   Comparison of Histological Measures of Skin Photoaging
}}

This area was generated with Dilib version V0.6.33.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Comparison of Histological Measures of Skin Photoaging

Comparison of Histological Measures of Skin Photoaging

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Abstract

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