AustralieFrV1, PascalFrancis, Corpus, bibRecord, 001623

Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

Identifieur interne : 001623 ( PascalFrancis/Corpus ); précédent : 001622; suivant : 001624

Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

Auteurs : Thibault Renoir ; Terence Y. Pang ; Laurence Lanfumey

Source :

Neuroscience and biobehavioral reviews [ 0149-7634 ] ; 2012.

RBID : Pascal:12-0073311

Descripteurs français

Pascal (Inist)
- Toxicité, Etat dépressif, Plasticité, Modèle animal, Substance toxicomanogène, Sérotonine, Système hypothalamohypophysosurrénalien, Neurogenèse, Article synthèse.

English descriptors

KwdEn :
- Animal model, Depression, Drug of abuse, Hypothalamohypophysoadrenal axis, Neurogenesis, Plasticity, Review, Serotonin, Toxicity.

Abstract

This review discusses recent research of mood disorders associated with the cessation of psychoactive substances, with an emphasis on preclinical studies that have been published in the last decade. Animal models exhibiting anhedonic and depressive-like behaviours associated with drug withdrawal have been used to study the neurobiology of mood disorders and have culminated in the identification of novel targets for the treatment of depressive-like symptoms. This review will introduce the behavioural as well as the neurochemical and plasticity changes in depressed patients and several animal models of depression. Following, we provide a more in-depth discussion of the role of serotonergic neurotransmission and Hypothalamic-Pituitary-Adrenal (HPA) axis regulation as well as the neurogenic changes occurring after chronic drug intake focusing on the withdrawal associated depression. Although we mainly focus on animal data, some relevant human studies are also discussed. Establishing the commonalities of depression and drug-seeking behaviour will allow us to elucidate the factors driving the high co-morbidity between mood disorders and drug dependence.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 12-0073311 INIST
ET :	Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models
AU :	RENOIR (Thibault); PANG (Terence Y.); LANFUMEY (Laurence)
AF :	Inserm UMR S894/75013 Paris/France (1 aut., 3 aut.); UPMC, Univ Paris 06, UMR S894/75013 Paris/France (1 aut., 3 aut.); Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne/Parkville/Australie (1 aut., 2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience and biobehavioral reviews; ISSN 0149-7634; Royaume-Uni; Da. 2012; Vol. 36; No. 1; Pp. 696-726; Bibl. 12 p.1/4
LA :	Anglais
EA :	This review discusses recent research of mood disorders associated with the cessation of psychoactive substances, with an emphasis on preclinical studies that have been published in the last decade. Animal models exhibiting anhedonic and depressive-like behaviours associated with drug withdrawal have been used to study the neurobiology of mood disorders and have culminated in the identification of novel targets for the treatment of depressive-like symptoms. This review will introduce the behavioural as well as the neurochemical and plasticity changes in depressed patients and several animal models of depression. Following, we provide a more in-depth discussion of the role of serotonergic neurotransmission and Hypothalamic-Pituitary-Adrenal (HPA) axis regulation as well as the neurogenic changes occurring after chronic drug intake focusing on the withdrawal associated depression. Although we mainly focus on animal data, some relevant human studies are also discussed. Establishing the commonalities of depression and drug-seeking behaviour will allow us to elucidate the factors driving the high co-morbidity between mood disorders and drug dependence.
CC :	002A26C; 002B18C07A
FD :	Toxicité; Etat dépressif; Plasticité; Modèle animal; Substance toxicomanogène; Sérotonine; Système hypothalamohypophysosurrénalien; Neurogenèse; Article synthèse
FG :	Trouble de l'humeur; Neurotransmetteur
ED :	Toxicity; Depression; Plasticity; Animal model; Drug of abuse; Serotonin; Hypothalamohypophysoadrenal axis; Neurogenesis; Review
EG :	Mood disorder; Neurotransmitter
SD :	Toxicidad; Estado depresivo; Plasticidad; Modelo animal; Sustancia toxicomanógena; Serotonina; Sistema hipotalamohipofisosuprarrenal; Neurogénesis; Artículo síntesis
LO :	INIST-18046.354000506708690430
ID :	12-0073311

Links to Exploration step

Pascal:12-0073311

Le document en format XML

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<ET>Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models</ET>
<AU>RENOIR (Thibault); PANG (Terence Y.); LANFUMEY (Laurence)</AU>
<AF>Inserm UMR S894/75013 Paris/France (1 aut., 3 aut.); UPMC, Univ Paris 06, UMR S894/75013 Paris/France (1 aut., 3 aut.); Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne/Parkville/Australie (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience and biobehavioral reviews; ISSN 0149-7634; Royaume-Uni; Da. 2012; Vol. 36; No. 1; Pp. 696-726; Bibl. 12 p.1/4</SO>
<LA>Anglais</LA>
<EA>This review discusses recent research of mood disorders associated with the cessation of psychoactive substances, with an emphasis on preclinical studies that have been published in the last decade. Animal models exhibiting anhedonic and depressive-like behaviours associated with drug withdrawal have been used to study the neurobiology of mood disorders and have culminated in the identification of novel targets for the treatment of depressive-like symptoms. This review will introduce the behavioural as well as the neurochemical and plasticity changes in depressed patients and several animal models of depression. Following, we provide a more in-depth discussion of the role of serotonergic neurotransmission and Hypothalamic-Pituitary-Adrenal (HPA) axis regulation as well as the neurogenic changes occurring after chronic drug intake focusing on the withdrawal associated depression. Although we mainly focus on animal data, some relevant human studies are also discussed. Establishing the commonalities of depression and drug-seeking behaviour will allow us to elucidate the factors driving the high co-morbidity between mood disorders and drug dependence.</EA>
<CC>002A26C; 002B18C07A</CC>
<FD>Toxicité; Etat dépressif; Plasticité; Modèle animal; Substance toxicomanogène; Sérotonine; Système hypothalamohypophysosurrénalien; Neurogenèse; Article synthèse</FD>
<FG>Trouble de l'humeur; Neurotransmetteur</FG>
<ED>Toxicity; Depression; Plasticity; Animal model; Drug of abuse; Serotonin; Hypothalamohypophysoadrenal axis; Neurogenesis; Review</ED>
<EG>Mood disorder; Neurotransmitter</EG>
<SD>Toxicidad; Estado depresivo; Plasticidad; Modelo animal; Sustancia toxicomanógena; Serotonina; Sistema hipotalamohipofisosuprarrenal; Neurogénesis; Artículo síntesis</SD>
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Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models

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