X-linked mental retardation : a comprehensive molecular screen of 47 candidate genes from a 7.4Mb interval in Xp11
Identifieur interne : 003507 ( PascalFrancis/Checkpoint ); précédent : 003506; suivant : 003508X-linked mental retardation : a comprehensive molecular screen of 47 candidate genes from a 7.4Mb interval in Xp11
Auteurs : Lars Riff Jensen [Allemagne] ; Steffen Lenzner [Allemagne] ; Bettina Moser [Allemagne] ; Kristine Freude [Allemagne] ; Andreas Tzschach [Allemagne] ; CHEN WEI [Allemagne] ; Jean-Pierre Fryns [Belgique] ; Jamel Chelly [France] ; Gillian Turner [Australie] ; Claude Moraine [France] ; Ben Hamel [Pays-Bas] ; Hans-Hilger Ropers [Allemagne] ; Andreas Walter Kuss [Allemagne]Source :
- European journal of human genetics [ 1018-4813 ] ; 2007.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Génétique.
English descriptors
- KwdEn :
Abstract
About 30% of the mutations causing nonsyndromic X-linked mental retardation (MRX) are thought to be located in Xp11 and in the pericentromeric region, with a particular clustering of gene defects in a 7.4Mb interval flanked by the genes ELK1 and ALAS2. To search for these mutations, 47 brain-expressed candidate genes located in this interval have been screened for mutations in up to 22 mental retardation (MR) families linked to this region. In total, we have identified 57 sequence variants in exons and splice sites of 27 genes. Based on these data, four novel MR genes were identified, but most of the sequence variants observed during this study have not yet been described. The purpose of this article is to present a comprehensive overview of this work and its outcome. It describes all sequence variants detected in 548 exons and their flanking sequences, including disease-causing mutations as well as possibly relevant polymorphic and silent sequence changes. We show that many of the studied genes are unlikely to play a major role in MRX. This information will help to avoid duplication of efforts in the ongoing endeavor to unravel the molecular causes of MRX.
Affiliations:
- Allemagne, Australie, Belgique, France, Pays-Bas
- Berlin, Centre-Val de Loire, Gueldre, Région Centre, Île-de-France
- Berlin, Nimègue, Paris, Tours
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level="a">X-linked mental retardation : a comprehensive molecular screen of 47 candidate genes from a 7.4Mb interval in Xp11</title><author><name sortKey="Riff Jensen, Lars" sort="Riff Jensen, Lars" uniqKey="Riff Jensen L" first="Lars" last="Riff Jensen">Lars Riff Jensen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lenzner, Steffen" sort="Lenzner, Steffen" uniqKey="Lenzner S" first="Steffen" last="Lenzner">Steffen Lenzner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Moser, Bettina" sort="Moser, Bettina" uniqKey="Moser B" first="Bettina" last="Moser">Bettina Moser</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Freude, Kristine" sort="Freude, Kristine" uniqKey="Freude K" first="Kristine" last="Freude">Kristine Freude</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tzschach, Andreas" sort="Tzschach, Andreas" uniqKey="Tzschach A" first="Andreas" last="Tzschach">Andreas Tzschach</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Chen Wei" sort="Chen Wei" uniqKey="Chen Wei" last="Chen Wei">CHEN WEI</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Fryns, Jean Pierre" sort="Fryns, Jean Pierre" uniqKey="Fryns J" first="Jean-Pierre" last="Fryns">Jean-Pierre Fryns</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre for Human Genetics, University Hospital Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>7 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Chelly, Jamel" sort="Chelly, Jamel" uniqKey="Chelly J" first="Jamel" last="Chelly">Jamel Chelly</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Departement de Génétique et Pathologie Moléculaire, Institut Cochin</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Turner, Gillian" sort="Turner, Gillian" uniqKey="Turner G" first="Gillian" last="Turner">Gillian Turner</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Hunter Genetics and University of Newcastle</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Hunter Genetics and University of Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Moraine, Claude" sort="Moraine, Claude" uniqKey="Moraine C" first="Claude" last="Moraine">Claude Moraine</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Services de Génétique-INSERM U316, CHU Bretonneau</s1><s2>Tours</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author><author><name sortKey="Hamel, Ben" sort="Hamel, Ben" uniqKey="Hamel B" first="Ben" last="Hamel">Ben Hamel</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Human Genetics, University Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>11 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Ropers, Hans Hilger" sort="Ropers, Hans Hilger" uniqKey="Ropers H" first="Hans-Hilger" last="Ropers">Hans-Hilger Ropers</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kuss, Andreas Walter" sort="Kuss, Andreas Walter" uniqKey="Kuss A" first="Andreas Walter" last="Kuss">Andreas Walter Kuss</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">European journal of human genetics</title><title level="j" type="abbreviated">Eur. j. hum. genet.</title><idno type="ISSN">1018-4813</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European journal of human genetics</title><title level="j" type="abbreviated">Eur. j. hum. genet.</title><idno type="ISSN">1018-4813</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Genetic determinism</term><term>Genetic disease</term><term>Genetics</term><term>Interval</term><term>Medical screening</term><term>Mental retardation</term><term>Mutation</term><term>Pathogenesis</term><term>Screening</term><term>Sex linked character</term><term>X-Chromosome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Arriération mentale</term><term>Maladie héréditaire</term><term>Chromosome X</term><term>Caractère lié au sexe</term><term>Dépistage</term><term>Pathogénie</term><term>Déterminisme génétique</term><term>Intervalle</term><term>Mutation</term><term>Criblage</term><term>Génétique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">About 30% of the mutations causing nonsyndromic X-linked mental retardation (MRX) are thought to be located in Xp11 and in the pericentromeric region, with a particular clustering of gene defects in a 7.4Mb interval flanked by the genes ELK1 and ALAS2. To search for these mutations, 47 brain-expressed candidate genes located in this interval have been screened for mutations in up to 22 mental retardation (MR) families linked to this region. In total, we have identified 57 sequence variants in exons and splice sites of 27 genes. Based on these data, four novel MR genes were identified, but most of the sequence variants observed during this study have not yet been described. The purpose of this article is to present a comprehensive overview of this work and its outcome. It describes all sequence variants detected in 548 exons and their flanking sequences, including disease-causing mutations as well as possibly relevant polymorphic and silent sequence changes. We show that many of the studied genes are unlikely to play a major role in MRX. This information will help to avoid duplication of efforts in the ongoing endeavor to unravel the molecular causes of MRX.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1018-4813</s0></fA01><fA03 i2="1"><s0>Eur. j. hum. genet.</s0></fA03><fA05><s2>15</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>X-linked mental retardation : a comprehensive molecular screen of 47 candidate genes from a 7.4Mb interval in Xp11</s1></fA08><fA11 i1="01" i2="1"><s1>RIFF JENSEN (Lars)</s1></fA11><fA11 i1="02" i2="1"><s1>LENZNER (Steffen)</s1></fA11><fA11 i1="03" i2="1"><s1>MOSER (Bettina)</s1></fA11><fA11 i1="04" i2="1"><s1>FREUDE (Kristine)</s1></fA11><fA11 i1="05" i2="1"><s1>TZSCHACH (Andreas)</s1></fA11><fA11 i1="06" i2="1"><s1>CHEN WEI</s1></fA11><fA11 i1="07" i2="1"><s1>FRYNS (Jean-Pierre)</s1></fA11><fA11 i1="08" i2="1"><s1>CHELLY (Jamel)</s1></fA11><fA11 i1="09" i2="1"><s1>TURNER (Gillian)</s1></fA11><fA11 i1="10" i2="1"><s1>MORAINE (Claude)</s1></fA11><fA11 i1="11" i2="1"><s1>HAMEL (Ben)</s1></fA11><fA11 i1="12" i2="1"><s1>ROPERS (Hans-Hilger)</s1></fA11><fA11 i1="13" i2="1"><s1>KUSS (Andreas Walter)</s1></fA11><fA14 i1="01"><s1>Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics</s1><s2>Berlin</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>Centre for Human Genetics, University Hospital Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Departement de Génétique et Pathologie Moléculaire, Institut Cochin</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="04"><s1>Hunter Genetics and University of Newcastle</s1><s2>New South Wales</s2><s3>AUS</s3><sZ>9 aut.</sZ></fA14><fA14 i1="05"><s1>Services de Génétique-INSERM U316, CHU Bretonneau</s1><s2>Tours</s2><s3>FRA</s3><sZ>10 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Human Genetics, University Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>11 aut.</sZ></fA14><fA20><s1>68-75</s1></fA20><fA21><s1>2007</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>27370</s2><s5>354000149695220110</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>27 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0423625</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>European journal of human genetics</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>About 30% of the mutations causing nonsyndromic X-linked mental retardation (MRX) are thought to be located in Xp11 and in the pericentromeric region, with a particular clustering of gene defects in a 7.4Mb interval flanked by the genes ELK1 and ALAS2. To search for these mutations, 47 brain-expressed candidate genes located in this interval have been screened for mutations in up to 22 mental retardation (MR) families linked to this region. In total, we have identified 57 sequence variants in exons and splice sites of 27 genes. Based on these data, four novel MR genes were identified, but most of the sequence variants observed during this study have not yet been described. The purpose of this article is to present a comprehensive overview of this work and its outcome. It describes all sequence variants detected in 548 exons and their flanking sequences, including disease-causing mutations as well as possibly relevant polymorphic and silent sequence changes. We show that many of the studied genes are unlikely to play a major role in MRX. This information will help to avoid duplication of efforts in the ongoing endeavor to unravel the molecular causes of MRX.</s0></fC01><fC02 i1="01" i2="X"><s0>002B23A</s0></fC02><fC02 i1="02" i2="X"><s0>002A04</s0></fC02><fC02 i1="03" i2="X"><s0>002A07</s0></fC02><fC02 i1="04" i2="X"><s0>002B18C12</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Arriération mentale</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Mental retardation</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Retraso mental</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Maladie héréditaire</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Genetic disease</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Chromosome X</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>X-Chromosome</s0><s5>10</s5><s6>«X»-Chromosome</s6></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Cromosoma X</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Caractère lié au sexe</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Sex linked character</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Carácter ligado al sexo</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Dépistage</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Medical screening</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Descubrimiento</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Pathogénie</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Pathogenesis</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Patogenia</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Déterminisme génétique</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Genetic determinism</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Determinismo genético</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Intervalle</s0><s5>15</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Interval</s0><s5>15</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Intervalo</s0><s5>15</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Mutation</s0><s5>16</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Mutation</s0><s5>16</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Mutación</s0><s5>16</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Criblage</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Screening</s0><s5>17</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Cernido</s0><s5>17</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Génétique</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Genetics</s0><s5>18</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Genética</s0><s5>18</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Déficience intellectuelle</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Intellectual deficiency</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Deficiencia intelectual</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Trouble développement</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Developmental disorder</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Trastorno desarrollo</s0><s5>38</s5></fC07><fN21><s1>274</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Pays-Bas</li></country><region><li>Berlin</li><li>Centre-Val de Loire</li><li>Gueldre</li><li>Région Centre</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Nimègue</li><li>Paris</li><li>Tours</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Riff Jensen, Lars" sort="Riff Jensen, Lars" uniqKey="Riff Jensen L" first="Lars" last="Riff Jensen">Lars Riff Jensen</name></region><name sortKey="Chen Wei" sort="Chen Wei" uniqKey="Chen Wei" last="Chen Wei">CHEN WEI</name><name sortKey="Freude, Kristine" sort="Freude, Kristine" uniqKey="Freude K" first="Kristine" last="Freude">Kristine Freude</name><name sortKey="Kuss, Andreas Walter" sort="Kuss, Andreas Walter" uniqKey="Kuss A" first="Andreas Walter" last="Kuss">Andreas Walter Kuss</name><name sortKey="Lenzner, Steffen" sort="Lenzner, Steffen" uniqKey="Lenzner S" first="Steffen" last="Lenzner">Steffen Lenzner</name><name sortKey="Moser, Bettina" sort="Moser, Bettina" uniqKey="Moser B" first="Bettina" last="Moser">Bettina Moser</name><name sortKey="Ropers, Hans Hilger" sort="Ropers, Hans Hilger" uniqKey="Ropers H" first="Hans-Hilger" last="Ropers">Hans-Hilger Ropers</name><name sortKey="Tzschach, Andreas" sort="Tzschach, Andreas" uniqKey="Tzschach A" first="Andreas" last="Tzschach">Andreas Tzschach</name></country><country name="Belgique"><noRegion><name sortKey="Fryns, Jean Pierre" sort="Fryns, Jean Pierre" uniqKey="Fryns J" first="Jean-Pierre" last="Fryns">Jean-Pierre Fryns</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Chelly, Jamel" sort="Chelly, Jamel" uniqKey="Chelly J" first="Jamel" last="Chelly">Jamel Chelly</name></region><name sortKey="Moraine, Claude" sort="Moraine, Claude" uniqKey="Moraine C" first="Claude" last="Moraine">Claude Moraine</name></country><country name="Australie"><noRegion><name sortKey="Turner, Gillian" sort="Turner, Gillian" uniqKey="Turner G" first="Gillian" last="Turner">Gillian Turner</name></noRegion></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Hamel, Ben" sort="Hamel, Ben" uniqKey="Hamel B" first="Ben" last="Hamel">Ben Hamel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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