Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
Identifieur interne : 001C74 ( PascalFrancis/Checkpoint ); précédent : 001C73; suivant : 001C75Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
Auteurs : Markus Juonala Juonala [Finlande] ; Costan G. Magnussen [Finlande, États-Unis, Australie] ; Gerald S. Berenson [France] ; Alison Venn [États-Unis] ; Trudy L. Burns [Canada] ; Matthew A. Sabin [Australie] ; Sathanur R. Srinivasan [France] ; Stephen R. Daniels [États-Unis] ; Patricia H. Davis [Canada] ; WEI CHEN [France] ; CONG SUN [Australie] ; Michael Cheung [Australie] ; Jorma S. A. Viikari [Finlande] ; Terence Dwyer [Australie] ; Olli T. Raitakari [Finlande]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).
Affiliations:
- Australie, Canada, Finlande, France, États-Unis
- Finlande occidentale, Iowa, Victoria (État)
- Iowa City, Melbourne, Turku
- Université de Melbourne, Université de l'Iowa
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:12-0004569Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</title><author><name sortKey="Juonala, Markus Juonala" sort="Juonala, Markus Juonala" uniqKey="Juonala M" first="Markus Juonala" last="Juonala">Markus Juonala Juonala</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hobart, TAS</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>New Orleans</wicri:noRegion><wicri:noRegion>Tulane University</wicri:noRegion><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hobart, TAS</wicri:noRegion></affiliation></author><author><name sortKey="Burns, Trudy L" sort="Burns, Trudy L" uniqKey="Burns T" first="Trudy L." last="Burns">Trudy L. Burns</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</wicri:noRegion><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Sabin, Matthew A" sort="Sabin, Matthew A" uniqKey="Sabin M" first="Matthew A." last="Sabin">Matthew A. Sabin</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>New Orleans</wicri:noRegion><wicri:noRegion>Tulane University</wicri:noRegion><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Daniels, Stephen R" sort="Daniels, Stephen R" uniqKey="Daniels S" first="Stephen R." last="Daniels">Stephen R. Daniels</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Pediatrics, University of Colorado Denver and Health Science Center</s1><s2>Aurora</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Aurora</wicri:noRegion></affiliation></author><author><name sortKey="Davis, Patricia H" sort="Davis, Patricia H" uniqKey="Davis P" first="Patricia H." last="Davis">Patricia H. Davis</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</wicri:noRegion><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>New Orleans</wicri:noRegion><wicri:noRegion>Tulane University</wicri:noRegion><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Cong Sun" sort="Cong Sun" uniqKey="Cong Sun" last="Cong Sun">CONG SUN</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Cheung, Michael" sort="Cheung, Michael" uniqKey="Cheung M" first="Michael" last="Cheung">Michael Cheung</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Clinical Physiology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0004569</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 12-0004569 INIST</idno><idno type="RBID">Pascal:12-0004569</idno><idno type="wicri:Area/PascalFrancis/Corpus">001763</idno><idno type="wicri:Area/PascalFrancis/Curation">004745</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001C74</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001C74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</title><author><name sortKey="Juonala, Markus Juonala" sort="Juonala, Markus Juonala" uniqKey="Juonala M" first="Markus Juonala" last="Juonala">Markus Juonala Juonala</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hobart, TAS</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>New Orleans</wicri:noRegion><wicri:noRegion>Tulane University</wicri:noRegion><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Hobart, TAS</wicri:noRegion></affiliation></author><author><name sortKey="Burns, Trudy L" sort="Burns, Trudy L" uniqKey="Burns T" first="Trudy L." last="Burns">Trudy L. Burns</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</wicri:noRegion><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Sabin, Matthew A" sort="Sabin, Matthew A" uniqKey="Sabin M" first="Matthew A." last="Sabin">Matthew A. Sabin</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>New Orleans</wicri:noRegion><wicri:noRegion>Tulane University</wicri:noRegion><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Daniels, Stephen R" sort="Daniels, Stephen R" uniqKey="Daniels S" first="Stephen R." last="Daniels">Stephen R. Daniels</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Pediatrics, University of Colorado Denver and Health Science Center</s1><s2>Aurora</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Aurora</wicri:noRegion></affiliation></author><author><name sortKey="Davis, Patricia H" sort="Davis, Patricia H" uniqKey="Davis P" first="Patricia H." last="Davis">Patricia H. Davis</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</wicri:noRegion><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>New Orleans</wicri:noRegion><wicri:noRegion>Tulane University</wicri:noRegion><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Cong Sun" sort="Cong Sun" uniqKey="Cong Sun" last="Cong Sun">CONG SUN</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Cheung, Michael" sort="Cheung, Michael" uniqKey="Cheung M" first="Michael" last="Cheung">Michael Cheung</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Clinical Physiology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>15 aut.</sZ></inist:fA14><country>Finlande</country><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose tissue</term><term>Adiposity</term><term>Adult</term><term>Cardiovascular disease</term><term>Cardiovascular risk</term><term>Child</term><term>Epidemiology</term><term>Medicine</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Enfant</term><term>Adiposité</term><term>Tissu adipeux</term><term>Adulte</term><term>Facteur risque</term><term>Risque cardiovasculaire</term><term>Epidémiologie</term><term>Médecine</term><term>Enfance</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term><term>Adulte</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-4793</s0></fA01><fA02 i1="01"><s0>NEJMAG</s0></fA02><fA03 i2="1"><s0>N. Engl. j. med.</s0></fA03><fA05><s2>365</s2></fA05><fA06><s2>20</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</s1></fA08><fA11 i1="01" i2="1"><s1>JUONALA (Markus Juonala)</s1></fA11><fA11 i1="02" i2="1"><s1>MAGNUSSEN (Costan G.)</s1></fA11><fA11 i1="03" i2="1"><s1>BERENSON (Gerald S.)</s1></fA11><fA11 i1="04" i2="1"><s1>VENN (Alison)</s1></fA11><fA11 i1="05" i2="1"><s1>BURNS (Trudy L.)</s1></fA11><fA11 i1="06" i2="1"><s1>SABIN (Matthew A.)</s1></fA11><fA11 i1="07" i2="1"><s1>SRINIVASAN (Sathanur R.)</s1></fA11><fA11 i1="08" i2="1"><s1>DANIELS (Stephen R.)</s1></fA11><fA11 i1="09" i2="1"><s1>DAVIS (Patricia H.)</s1></fA11><fA11 i1="10" i2="1"><s1>WEI CHEN</s1></fA11><fA11 i1="11" i2="1"><s1>CONG SUN</s1></fA11><fA11 i1="12" i2="1"><s1>CHEUNG (Michael)</s1></fA11><fA11 i1="13" i2="1"><s1>VIIKARI (Jorma S. A.)</s1></fA11><fA11 i1="14" i2="1"><s1>DWYER (Terence)</s1></fA11><fA11 i1="15" i2="1"><s1>RAITAKARI (Olli T.)</s1></fA11><fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Clinical Physiology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>15 aut.</sZ></fA14><fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>9 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Pediatrics, University of Colorado Denver and Health Science Center</s1><s2>Aurora</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1876-1885</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6013</s2><s5>354000507304160050</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>30 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0004569</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The New England journal of medicine</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).</s0></fC01><fC02 i1="01" i2="X"><s0>002B01</s0></fC02><fC02 i1="02" i2="X"><s0>002B30A01A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Enfant</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Child</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Niño</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Adiposité</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Adiposity</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Adiposidad</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tissu adipeux</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Adipose tissue</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tejido adiposo</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Adulte</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Adult</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Adulto</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Facteur risque</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Risk factor</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Risque cardiovasculaire</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Cardiovascular risk</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Riesgo cardiovascular</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Epidemiology</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Epidemiología</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Médecine</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Medicine</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Medicina</s0><s5>12</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Enfance</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fN21><s1>002</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Australie</li><li>Canada</li><li>Finlande</li><li>France</li><li>États-Unis</li></country><region><li>Finlande occidentale</li><li>Iowa</li><li>Victoria (État)</li></region><settlement><li>Iowa City</li><li>Melbourne</li><li>Turku</li></settlement><orgName><li>Université de Melbourne</li><li>Université de l'Iowa</li></orgName></list><tree><country name="Finlande"><region name="Finlande occidentale"><name sortKey="Juonala, Markus Juonala" sort="Juonala, Markus Juonala" uniqKey="Juonala M" first="Markus Juonala" last="Juonala">Markus Juonala Juonala</name></region><name sortKey="Juonala, Markus Juonala" sort="Juonala, Markus Juonala" uniqKey="Juonala M" first="Markus Juonala" last="Juonala">Markus Juonala Juonala</name><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name></country><country name="États-Unis"><noRegion><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name></noRegion><name sortKey="Daniels, Stephen R" sort="Daniels, Stephen R" uniqKey="Daniels S" first="Stephen R." last="Daniels">Stephen R. Daniels</name><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name></region><name sortKey="Cheung, Michael" sort="Cheung, Michael" uniqKey="Cheung M" first="Michael" last="Cheung">Michael Cheung</name><name sortKey="Cheung, Michael" sort="Cheung, Michael" uniqKey="Cheung M" first="Michael" last="Cheung">Michael Cheung</name><name sortKey="Cong Sun" sort="Cong Sun" uniqKey="Cong Sun" last="Cong Sun">CONG SUN</name><name sortKey="Cong Sun" sort="Cong Sun" uniqKey="Cong Sun" last="Cong Sun">CONG SUN</name><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name><name sortKey="Sabin, Matthew A" sort="Sabin, Matthew A" uniqKey="Sabin M" first="Matthew A." last="Sabin">Matthew A. Sabin</name><name sortKey="Sabin, Matthew A" sort="Sabin, Matthew A" uniqKey="Sabin M" first="Matthew A." last="Sabin">Matthew A. Sabin</name></country><country name="France"><noRegion><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name></noRegion><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name></country><country name="Canada"><region name="Iowa"><name sortKey="Burns, Trudy L" sort="Burns, Trudy L" uniqKey="Burns T" first="Trudy L." last="Burns">Trudy L. Burns</name></region><name sortKey="Davis, Patricia H" sort="Davis, Patricia H" uniqKey="Davis P" first="Patricia H." last="Davis">Patricia H. Davis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C74 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 001C74 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:12-0004569
|texte= Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
}}
| This area was generated with Dilib version V0.6.33. |  |