Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
Identifieur interne : 001763 ( PascalFrancis/Corpus ); précédent : 001762; suivant : 001764Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
Auteurs : Markus Juonala Juonala ; Costan G. Magnussen ; Gerald S. Berenson ; Alison Venn ; Trudy L. Burns ; Matthew A. Sabin ; Sathanur R. Srinivasan ; Stephen R. Daniels ; Patricia H. Davis ; WEI CHEN ; CONG SUN ; Michael Cheung ; Jorma S. A. Viikari ; Terence Dwyer ; Olli T. RaitakariSource :
- The New England journal of medicine [ 0028-4793 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
| pA |
|
|---|
Format Inist (serveur)
| NO : | PASCAL 12-0004569 INIST |
|---|---|
| ET : | Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors |
| AU : | JUONALA (Markus Juonala); MAGNUSSEN (Costan G.); BERENSON (Gerald S.); VENN (Alison); BURNS (Trudy L.); SABIN (Matthew A.); SRINIVASAN (Sathanur R.); DANIELS (Stephen R.); DAVIS (Patricia H.); WEI CHEN; CONG SUN; CHEUNG (Michael); VIIKARI (Jorma S. A.); DWYER (Terence); RAITAKARI (Olli T.) |
| AF : | Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital/Turku/Finlande (1 aut., 2 aut., 15 aut.); Department of Medicine, University of Turku and Turku University Hospital/Turku/Finlande (1 aut., 13 aut.); Department of Clinical Physiology, University of Turku and Turku University Hospital/Turku/Finlande (15 aut.); Menzies Research Institute, University of Tasmania/Hobart, TAS/Etats-Unis (2 aut., 4 aut.); Murdoch Childrens Research Institute and the University of Melbourne/Australie (2 aut., 6 aut., 11 aut., 12 aut., 14 aut.); Department of Paediatrics at the Royal Children's Hospital/Melbourne/Australie (6 aut., 11 aut., 12 aut.); Tulane Center for Cardiovascular Health, Tulane University/New Orleans/France (3 aut., 7 aut., 10 aut.); Department of Epidemiology, College of Public Health, University of Iowa, Iowa City/Canada (5 aut.); Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City/Canada (9 aut.); Department of Pediatrics, University of Colorado Denver and Health Science Center/Aurora/Etats-Unis (8 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | The New England journal of medicine; ISSN 0028-4793; Coden NEJMAG; Etats-Unis; Da. 2011; Vol. 365; No. 20; Pp. 1876-1885; Bibl. 30 ref. |
| LA : | Anglais |
| EA : | BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.). |
| CC : | 002B01; 002B30A01A |
| FD : | Pathologie de l'appareil circulatoire; Enfant; Adiposité; Tissu adipeux; Adulte; Facteur risque; Risque cardiovasculaire; Epidémiologie; Médecine; Enfance |
| FG : | Homme |
| ED : | Cardiovascular disease; Child; Adiposity; Adipose tissue; Adult; Risk factor; Cardiovascular risk; Epidemiology; Medicine |
| EG : | Human |
| SD : | Aparato circulatorio patología; Niño; Adiposidad; Tejido adiposo; Adulto; Factor riesgo; Riesgo cardiovascular; Epidemiología; Medicina |
| LO : | INIST-6013.354000507304160050 |
| ID : | 12-0004569 |
Links to Exploration step
Pascal:12-0004569Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</title><author><name sortKey="Juonala, Markus Juonala" sort="Juonala, Markus Juonala" uniqKey="Juonala M" first="Markus Juonala" last="Juonala">Markus Juonala Juonala</name><affiliation><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name><affiliation><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name><affiliation><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name><affiliation><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Burns, Trudy L" sort="Burns, Trudy L" uniqKey="Burns T" first="Trudy L." last="Burns">Trudy L. Burns</name><affiliation><inist:fA14 i1="08"><s1>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sabin, Matthew A" sort="Sabin, Matthew A" uniqKey="Sabin M" first="Matthew A." last="Sabin">Matthew A. Sabin</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><affiliation><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Daniels, Stephen R" sort="Daniels, Stephen R" uniqKey="Daniels S" first="Stephen R." last="Daniels">Stephen R. Daniels</name><affiliation><inist:fA14 i1="10"><s1>Department of Pediatrics, University of Colorado Denver and Health Science Center</s1><s2>Aurora</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Davis, Patricia H" sort="Davis, Patricia H" uniqKey="Davis P" first="Patricia H." last="Davis">Patricia H. Davis</name><affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cong Sun" sort="Cong Sun" uniqKey="Cong Sun" last="Cong Sun">CONG SUN</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cheung, Michael" sort="Cheung, Michael" uniqKey="Cheung M" first="Michael" last="Cheung">Michael Cheung</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name><affiliation><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Clinical Physiology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0004569</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 12-0004569 INIST</idno><idno type="RBID">Pascal:12-0004569</idno><idno type="wicri:Area/PascalFrancis/Corpus">001763</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</title><author><name sortKey="Juonala, Markus Juonala" sort="Juonala, Markus Juonala" uniqKey="Juonala M" first="Markus Juonala" last="Juonala">Markus Juonala Juonala</name><affiliation><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Magnussen, Costan G" sort="Magnussen, Costan G" uniqKey="Magnussen C" first="Costan G." last="Magnussen">Costan G. Magnussen</name><affiliation><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S." last="Berenson">Gerald S. Berenson</name><affiliation><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Venn, Alison" sort="Venn, Alison" uniqKey="Venn A" first="Alison" last="Venn">Alison Venn</name><affiliation><inist:fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Burns, Trudy L" sort="Burns, Trudy L" uniqKey="Burns T" first="Trudy L." last="Burns">Trudy L. Burns</name><affiliation><inist:fA14 i1="08"><s1>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Sabin, Matthew A" sort="Sabin, Matthew A" uniqKey="Sabin M" first="Matthew A." last="Sabin">Matthew A. Sabin</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Srinivasan, Sathanur R" sort="Srinivasan, Sathanur R" uniqKey="Srinivasan S" first="Sathanur R." last="Srinivasan">Sathanur R. Srinivasan</name><affiliation><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Daniels, Stephen R" sort="Daniels, Stephen R" uniqKey="Daniels S" first="Stephen R." last="Daniels">Stephen R. Daniels</name><affiliation><inist:fA14 i1="10"><s1>Department of Pediatrics, University of Colorado Denver and Health Science Center</s1><s2>Aurora</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Davis, Patricia H" sort="Davis, Patricia H" uniqKey="Davis P" first="Patricia H." last="Davis">Patricia H. Davis</name><affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wei Chen" sort="Wei Chen" uniqKey="Wei Chen" last="Wei Chen">WEI CHEN</name><affiliation><inist:fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cong Sun" sort="Cong Sun" uniqKey="Cong Sun" last="Cong Sun">CONG SUN</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cheung, Michael" sort="Cheung, Michael" uniqKey="Cheung M" first="Michael" last="Cheung">Michael Cheung</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Viikari, Jorma S A" sort="Viikari, Jorma S A" uniqKey="Viikari J" first="Jorma S. A." last="Viikari">Jorma S. A. Viikari</name><affiliation><inist:fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Dwyer, Terence" sort="Dwyer, Terence" uniqKey="Dwyer T" first="Terence" last="Dwyer">Terence Dwyer</name><affiliation><inist:fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Raitakari, Olli T" sort="Raitakari, Olli T" uniqKey="Raitakari O" first="Olli T." last="Raitakari">Olli T. Raitakari</name><affiliation><inist:fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Clinical Physiology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>15 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose tissue</term><term>Adiposity</term><term>Adult</term><term>Cardiovascular disease</term><term>Cardiovascular risk</term><term>Child</term><term>Epidemiology</term><term>Medicine</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil circulatoire</term><term>Enfant</term><term>Adiposité</term><term>Tissu adipeux</term><term>Adulte</term><term>Facteur risque</term><term>Risque cardiovasculaire</term><term>Epidémiologie</term><term>Médecine</term><term>Enfance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-4793</s0></fA01><fA02 i1="01"><s0>NEJMAG</s0></fA02><fA03 i2="1"><s0>N. Engl. j. med.</s0></fA03><fA05><s2>365</s2></fA05><fA06><s2>20</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</s1></fA08><fA11 i1="01" i2="1"><s1>JUONALA (Markus Juonala)</s1></fA11><fA11 i1="02" i2="1"><s1>MAGNUSSEN (Costan G.)</s1></fA11><fA11 i1="03" i2="1"><s1>BERENSON (Gerald S.)</s1></fA11><fA11 i1="04" i2="1"><s1>VENN (Alison)</s1></fA11><fA11 i1="05" i2="1"><s1>BURNS (Trudy L.)</s1></fA11><fA11 i1="06" i2="1"><s1>SABIN (Matthew A.)</s1></fA11><fA11 i1="07" i2="1"><s1>SRINIVASAN (Sathanur R.)</s1></fA11><fA11 i1="08" i2="1"><s1>DANIELS (Stephen R.)</s1></fA11><fA11 i1="09" i2="1"><s1>DAVIS (Patricia H.)</s1></fA11><fA11 i1="10" i2="1"><s1>WEI CHEN</s1></fA11><fA11 i1="11" i2="1"><s1>CONG SUN</s1></fA11><fA11 i1="12" i2="1"><s1>CHEUNG (Michael)</s1></fA11><fA11 i1="13" i2="1"><s1>VIIKARI (Jorma S. A.)</s1></fA11><fA11 i1="14" i2="1"><s1>DWYER (Terence)</s1></fA11><fA11 i1="15" i2="1"><s1>RAITAKARI (Olli T.)</s1></fA11><fA14 i1="01"><s1>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medicine, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Clinical Physiology, University of Turku and Turku University Hospital</s1><s2>Turku</s2><s3>FIN</s3><sZ>15 aut.</sZ></fA14><fA14 i1="04"><s1>Menzies Research Institute, University of Tasmania</s1><s2>Hobart, TAS</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Murdoch Childrens Research Institute and the University of Melbourne</s1><s3>AUS</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Paediatrics at the Royal Children's Hospital</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="07"><s1>Tulane Center for Cardiovascular Health, Tulane University</s1><s2>New Orleans</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Epidemiology, College of Public Health, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City</s1><s3>CAN</s3><sZ>9 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Pediatrics, University of Colorado Denver and Health Science Center</s1><s2>Aurora</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA20><s1>1876-1885</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6013</s2><s5>354000507304160050</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>30 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0004569</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The New England journal of medicine</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).</s0></fC01><fC02 i1="01" i2="X"><s0>002B01</s0></fC02><fC02 i1="02" i2="X"><s0>002B30A01A</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Enfant</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Child</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Niño</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Adiposité</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Adiposity</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Adiposidad</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tissu adipeux</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Adipose tissue</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tejido adiposo</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Adulte</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Adult</s0><s5>06</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Adulto</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Facteur risque</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Risk factor</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Factor riesgo</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Risque cardiovasculaire</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Cardiovascular risk</s0><s5>09</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Riesgo cardiovascular</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Epidémiologie</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Epidemiology</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Epidemiología</s0><s5>11</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Médecine</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Medicine</s0><s5>12</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Medicina</s0><s5>12</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Enfance</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0></fC07><fN21><s1>002</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 12-0004569 INIST</NO><ET>Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors</ET><AU>JUONALA (Markus Juonala); MAGNUSSEN (Costan G.); BERENSON (Gerald S.); VENN (Alison); BURNS (Trudy L.); SABIN (Matthew A.); SRINIVASAN (Sathanur R.); DANIELS (Stephen R.); DAVIS (Patricia H.); WEI CHEN; CONG SUN; CHEUNG (Michael); VIIKARI (Jorma S. A.); DWYER (Terence); RAITAKARI (Olli T.)</AU><AF>Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital/Turku/Finlande (1 aut., 2 aut., 15 aut.); Department of Medicine, University of Turku and Turku University Hospital/Turku/Finlande (1 aut., 13 aut.); Department of Clinical Physiology, University of Turku and Turku University Hospital/Turku/Finlande (15 aut.); Menzies Research Institute, University of Tasmania/Hobart, TAS/Etats-Unis (2 aut., 4 aut.); Murdoch Childrens Research Institute and the University of Melbourne/Australie (2 aut., 6 aut., 11 aut., 12 aut., 14 aut.); Department of Paediatrics at the Royal Children's Hospital/Melbourne/Australie (6 aut., 11 aut., 12 aut.); Tulane Center for Cardiovascular Health, Tulane University/New Orleans/France (3 aut., 7 aut., 10 aut.); Department of Epidemiology, College of Public Health, University of Iowa, Iowa City/Canada (5 aut.); Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City/Canada (9 aut.); Department of Pediatrics, University of Colorado Denver and Health Science Center/Aurora/Etats-Unis (8 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>The New England journal of medicine; ISSN 0028-4793; Coden NEJMAG; Etats-Unis; Da. 2011; Vol. 365; No. 20; Pp. 1876-1885; Bibl. 30 ref.</SO><LA>Anglais</LA><EA>BACKGROUND Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults. METHODS We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of the height in meters). The mean length of follow-up was 23 years. To define high adiposity status, international age-specific and sex-specific BMI cutoff points for overweight and obesity were used for children, and a BMI cutoff point of 30 was used for adults. RESULTS Data were available for 6328 subjects. Subjects with consistently high adiposity status from childhood to adulthood, as compared with persons who had a normal BMI as children and were nonobese as adults, had an increased risk of type 2 diabetes (relative risk, 5.4; 95% confidence interval [CI], 3.4 to 8.5), hypertension (relative risk, 2.7; 95% CI, 2.2 to 3.3), elevated low-density lipoprotein cholesterol levels (relative risk, 1.8; 95% CI, 1.4 to 2.3), reduced high-density lipoprotein cholesterol levels (relative risk, 2.1; 95% CI, 1.8 to 2.5), elevated triglyceride levels (relative risk, 3.0; 95% CI, 2.4 to 3.8), and carotid-artery atherosclerosis (increased intima-media thickness of the carotid artery) (relative risk, 1.7; 95% CI, 1.4 to 2.2) (P≤0.002 for all comparisons). Persons who were overweight or obese during childhood but were nonobese as adults had risks of the outcomes that were similar to those of persons who had a normal BMI consistently from childhood to adulthood (P>0.20 for all comparisons). CONCLUSIONS Overweight or obese children who were obese as adults had increased risks of type 2 diabetes, hypertension, dyslipidemia, and carotid-artery atherosclerosis. The risks of these outcomes among overweight or obese children who became nonobese by adulthood were similar to those among persons who were never obese. (Funded by the Academy of Finland and others.).</EA><CC>002B01; 002B30A01A</CC><FD>Pathologie de l'appareil circulatoire; Enfant; Adiposité; Tissu adipeux; Adulte; Facteur risque; Risque cardiovasculaire; Epidémiologie; Médecine; Enfance</FD><FG>Homme</FG><ED>Cardiovascular disease; Child; Adiposity; Adipose tissue; Adult; Risk factor; Cardiovascular risk; Epidemiology; Medicine</ED><EG>Human</EG><SD>Aparato circulatorio patología; Niño; Adiposidad; Tejido adiposo; Adulto; Factor riesgo; Riesgo cardiovascular; Epidemiología; Medicina</SD><LO>INIST-6013.354000507304160050</LO><ID>12-0004569</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001763 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 001763 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PascalFrancis
|étape= Corpus
|type= RBID
|clé= Pascal:12-0004569
|texte= Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors
}}
| This area was generated with Dilib version V0.6.33. |  |