A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation
Identifieur interne : 001408 ( PascalFrancis/Checkpoint ); précédent : 001407; suivant : 001409A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation
Auteurs : Runjan Chetty [Royaume-Uni] ; Pelvender Gill [Royaume-Uni] ; Dhirendra Govender [Afrique du Sud] ; Adrian Bateman [Royaume-Uni] ; HEE JIN CHANG [Corée du Sud] ; David Driman [Canada] ; Fraser Duthie [Royaume-Uni] ; Marisa Gomez [Espagne] ; Eleanor Jaynes [Royaume-Uni] ; CHEOK SOON LEE [Australie] ; Michael Locketz [Afrique du Sud] ; Claudia Mescoli [Italie] ; Corwyn Rowsell [Canada] ; Anne Rullier [France] ; Stefano Serra [Canada] ; Neil Shepherd [Royaume-Uni] ; Eva Szentgyorgyi [Canada] ; Rajkumar Vajpeyi [Canada] ; LAI MUN WANG [Royaume-Uni]Source :
- Virchows Archiv [ 0945-6317 ] ; 2012.
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Abstract
To ascertain the approach and degree of consensus of pathologists in the handling and regression grading of colorectal cancer resection specimens treated with neoadjuvant chemoradiation, a ten-part questionnaire was circulated to 18 gastrointestinal pathologists in eight countries. The questions were specific and addressed pertinent issues related to colorectal cancer with neoadjuvant chemoradiation. There is a lack of consensus on how to handle the specimen, number of sections taken, correlation with pre-and post-operative radiological imaging, and especially, regression grading schema employed. Consensus in the form of guidelines is required so that the pathological assessment of these specimens will provide clinically relevant information for patient management, irrespective of location.
Affiliations:
- Afrique du Sud, Australie, Canada, Corée du Sud, Espagne, France, Italie, Royaume-Uni
- Angleterre, Grand Londres, Nouvelle-Galles du Sud, Ontario, Oxfordshire
- Londres, Oxford, Sydney, Toronto
- Université d'Oxford, Université de Toronto
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation</title><author><name sortKey="Chetty, Runjan" sort="Chetty, Runjan" uniqKey="Chetty R" first="Runjan" last="Chetty">Runjan Chetty</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Gill, Pelvender" sort="Gill, Pelvender" uniqKey="Gill P" first="Pelvender" last="Gill">Pelvender Gill</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Govender, Dhirendra" sort="Govender, Dhirendra" uniqKey="Govender D" first="Dhirendra" last="Govender">Dhirendra Govender</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Anatomical Pathology, University of Cape Town/ Groote Schuur Hospital</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Bateman, Adrian" sort="Bateman, Adrian" uniqKey="Bateman A" first="Adrian" last="Bateman">Adrian Bateman</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Cellular Pathology, Southampton University Hospitals NHS Trust</s1><s2>Southampton</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Hee Jin Chang" sort="Hee Jin Chang" uniqKey="Hee Jin Chang" last="Hee Jin Chang">HEE JIN CHANG</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center for Colorectal Cancer, Research Institute & Hospital, National Cancer Center</s1><s2>Goyang</s2><s3>KOR</s3><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Driman, David" sort="Driman, David" uniqKey="Driman D" first="David" last="Driman">David Driman</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Pathology, London Health Sciences Centre/ University of Western Ontario</s1><s2>London</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Duthie, Fraser" sort="Duthie, Fraser" uniqKey="Duthie F" first="Fraser" last="Duthie">Fraser Duthie</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Pathology, Western Infirmary</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Gomez, Marisa" sort="Gomez, Marisa" uniqKey="Gomez M" first="Marisa" last="Gomez">Marisa Gomez</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Pathology, Hospital de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Jaynes, Eleanor" sort="Jaynes, Eleanor" uniqKey="Jaynes E" first="Eleanor" last="Jaynes">Eleanor Jaynes</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Cellular Pathology, Southampton University Hospitals NHS Trust</s1><s2>Southampton</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Cheok Soon Lee" sort="Cheok Soon Lee" uniqKey="Cheok Soon Lee" last="Cheok Soon Lee">CHEOK SOON LEE</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Pathology, Liverpool & Royal Prince Alfred Hospital, University of Western Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Locketz, Michael" sort="Locketz, Michael" uniqKey="Locketz M" first="Michael" last="Locketz">Michael Locketz</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Anatomical Pathology, University of Cape Town/ Groote Schuur Hospital</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Mescoli, Claudia" sort="Mescoli, Claudia" uniqKey="Mescoli C" first="Claudia" last="Mescoli">Claudia Mescoli</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Diagnostic Sciences & Special Therapies, Pathology Unit, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Rowsell, Corwyn" sort="Rowsell, Corwyn" uniqKey="Rowsell C" first="Corwyn" last="Rowsell">Corwyn Rowsell</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Pathology, Sunnybrook Health Science Center/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rullier, Anne" sort="Rullier, Anne" uniqKey="Rullier A" first="Anne" last="Rullier">Anne Rullier</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Pathology, CHU Bordeaux</s1><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>CHU Bordeaux</wicri:noRegion><wicri:noRegion>Department of Pathology, CHU Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Serra, Stefano" sort="Serra, Stefano" uniqKey="Serra S" first="Stefano" last="Serra">Stefano Serra</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Shepherd, Neil" sort="Shepherd, Neil" uniqKey="Shepherd N" first="Neil" last="Shepherd">Neil Shepherd</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital</s1><s2>Cheltenham</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cheltenham</wicri:noRegion></affiliation></author><author><name sortKey="Szentgyorgyi, Eva" sort="Szentgyorgyi, Eva" uniqKey="Szentgyorgyi E" first="Eva" last="Szentgyorgyi">Eva Szentgyorgyi</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Vajpeyi, Rajkumar" sort="Vajpeyi, Rajkumar" uniqKey="Vajpeyi R" first="Rajkumar" last="Vajpeyi">Rajkumar Vajpeyi</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Lai Mun Wang" sort="Lai Mun Wang" uniqKey="Lai Mun Wang" last="Lai Mun Wang">LAI MUN WANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0158054</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0158054 INIST</idno><idno type="RBID">Pascal:12-0158054</idno><idno type="wicri:Area/PascalFrancis/Corpus">001494</idno><idno type="wicri:Area/PascalFrancis/Curation">004A18</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001408</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001408</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation</title><author><name sortKey="Chetty, Runjan" sort="Chetty, Runjan" uniqKey="Chetty R" first="Runjan" last="Chetty">Runjan Chetty</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Gill, Pelvender" sort="Gill, Pelvender" uniqKey="Gill P" first="Pelvender" last="Gill">Pelvender Gill</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Govender, Dhirendra" sort="Govender, Dhirendra" uniqKey="Govender D" first="Dhirendra" last="Govender">Dhirendra Govender</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Anatomical Pathology, University of Cape Town/ Groote Schuur Hospital</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Bateman, Adrian" sort="Bateman, Adrian" uniqKey="Bateman A" first="Adrian" last="Bateman">Adrian Bateman</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Cellular Pathology, Southampton University Hospitals NHS Trust</s1><s2>Southampton</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Hee Jin Chang" sort="Hee Jin Chang" uniqKey="Hee Jin Chang" last="Hee Jin Chang">HEE JIN CHANG</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Center for Colorectal Cancer, Research Institute & Hospital, National Cancer Center</s1><s2>Goyang</s2><s3>KOR</s3><sZ>5 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>Goyang</wicri:noRegion></affiliation></author><author><name sortKey="Driman, David" sort="Driman, David" uniqKey="Driman D" first="David" last="Driman">David Driman</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Pathology, London Health Sciences Centre/ University of Western Ontario</s1><s2>London</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Duthie, Fraser" sort="Duthie, Fraser" uniqKey="Duthie F" first="Fraser" last="Duthie">Fraser Duthie</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Pathology, Western Infirmary</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Glasgow, Scotland</wicri:noRegion></affiliation></author><author><name sortKey="Gomez, Marisa" sort="Gomez, Marisa" uniqKey="Gomez M" first="Marisa" last="Gomez">Marisa Gomez</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Pathology, Hospital de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Jaynes, Eleanor" sort="Jaynes, Eleanor" uniqKey="Jaynes E" first="Eleanor" last="Jaynes">Eleanor Jaynes</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Cellular Pathology, Southampton University Hospitals NHS Trust</s1><s2>Southampton</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Cheok Soon Lee" sort="Cheok Soon Lee" uniqKey="Cheok Soon Lee" last="Cheok Soon Lee">CHEOK SOON LEE</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Pathology, Liverpool & Royal Prince Alfred Hospital, University of Western Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Locketz, Michael" sort="Locketz, Michael" uniqKey="Locketz M" first="Michael" last="Locketz">Michael Locketz</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Anatomical Pathology, University of Cape Town/ Groote Schuur Hospital</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Mescoli, Claudia" sort="Mescoli, Claudia" uniqKey="Mescoli C" first="Claudia" last="Mescoli">Claudia Mescoli</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Diagnostic Sciences & Special Therapies, Pathology Unit, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>12 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Rowsell, Corwyn" sort="Rowsell, Corwyn" uniqKey="Rowsell C" first="Corwyn" last="Rowsell">Corwyn Rowsell</name><affiliation wicri:level="4"><inist:fA14 i1="10"><s1>Department of Pathology, Sunnybrook Health Science Center/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Rullier, Anne" sort="Rullier, Anne" uniqKey="Rullier A" first="Anne" last="Rullier">Anne Rullier</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Pathology, CHU Bordeaux</s1><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>CHU Bordeaux</wicri:noRegion><wicri:noRegion>Department of Pathology, CHU Bordeaux</wicri:noRegion></affiliation></author><author><name sortKey="Serra, Stefano" sort="Serra, Stefano" uniqKey="Serra S" first="Stefano" last="Serra">Stefano Serra</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Shepherd, Neil" sort="Shepherd, Neil" uniqKey="Shepherd N" first="Neil" last="Shepherd">Neil Shepherd</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital</s1><s2>Cheltenham</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cheltenham</wicri:noRegion></affiliation></author><author><name sortKey="Szentgyorgyi, Eva" sort="Szentgyorgyi, Eva" uniqKey="Szentgyorgyi E" first="Eva" last="Szentgyorgyi">Eva Szentgyorgyi</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Vajpeyi, Rajkumar" sort="Vajpeyi, Rajkumar" uniqKey="Vajpeyi R" first="Rajkumar" last="Vajpeyi">Rajkumar Vajpeyi</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Lai Mun Wang" sort="Lai Mun Wang" uniqKey="Lai Mun Wang" last="Lai Mun Wang">LAI MUN WANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j" type="main">Virchows Archiv</title><title level="j" type="abbreviated">Virchows Arch.</title><idno type="ISSN">0945-6317</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Virchows Archiv</title><title level="j" type="abbreviated">Virchows Arch.</title><idno type="ISSN">0945-6317</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Chemotherapy</term><term>Colorectal cancer</term><term>Combined treatment</term><term>Histological grading</term><term>Neoadjuvant treatment</term><term>Radiotherapy</term><term>Regression</term><term>Surgical resection</term><term>Surveillance</term><term>Survey</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cancer colorectal</term><term>Surveillance</term><term>Enquête</term><term>Résection chirurgicale</term><term>Régression</term><term>Grade histologique</term><term>Traitement associé</term><term>Traitement néoadjuvant</term><term>Anatomopathologie</term><term>Radiothérapie</term><term>Chimiothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To ascertain the approach and degree of consensus of pathologists in the handling and regression grading of colorectal cancer resection specimens treated with neoadjuvant chemoradiation, a ten-part questionnaire was circulated to 18 gastrointestinal pathologists in eight countries. The questions were specific and addressed pertinent issues related to colorectal cancer with neoadjuvant chemoradiation. There is a lack of consensus on how to handle the specimen, number of sections taken, correlation with pre-and post-operative radiological imaging, and especially, regression grading schema employed. Consensus in the form of guidelines is required so that the pathological assessment of these specimens will provide clinically relevant information for patient management, irrespective of location.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0945-6317</s0></fA01><fA03 i2="1"><s0>Virchows Arch.</s0></fA03><fA05><s2>460</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation</s1></fA08><fA11 i1="01" i2="1"><s1>CHETTY (Runjan)</s1></fA11><fA11 i1="02" i2="1"><s1>GILL (Pelvender)</s1></fA11><fA11 i1="03" i2="1"><s1>GOVENDER (Dhirendra)</s1></fA11><fA11 i1="04" i2="1"><s1>BATEMAN (Adrian)</s1></fA11><fA11 i1="05" i2="1"><s1>HEE JIN CHANG</s1></fA11><fA11 i1="06" i2="1"><s1>DRIMAN (David)</s1></fA11><fA11 i1="07" i2="1"><s1>DUTHIE (Fraser)</s1></fA11><fA11 i1="08" i2="1"><s1>GOMEZ (Marisa)</s1></fA11><fA11 i1="09" i2="1"><s1>JAYNES (Eleanor)</s1></fA11><fA11 i1="10" i2="1"><s1>CHEOK SOON LEE</s1></fA11><fA11 i1="11" i2="1"><s1>LOCKETZ (Michael)</s1></fA11><fA11 i1="12" i2="1"><s1>MESCOLI (Claudia)</s1></fA11><fA11 i1="13" i2="1"><s1>ROWSELL (Corwyn)</s1></fA11><fA11 i1="14" i2="1"><s1>RULLIER (Anne)</s1></fA11><fA11 i1="15" i2="1"><s1>SERRA (Stefano)</s1></fA11><fA11 i1="16" i2="1"><s1>SHEPHERD (Neil)</s1></fA11><fA11 i1="17" i2="1"><s1>SZENTGYORGYI (Eva)</s1></fA11><fA11 i1="18" i2="1"><s1>VAJPEYI (Rajkumar)</s1></fA11><fA11 i1="19" i2="1"><s1>LAI MUN WANG</s1></fA11><fA14 i1="01"><s1>Department of Cellular Pathology/Biomedical Research Centre/ Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital and University of Oxford</s1><s2>Oxford</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>19 aut.</sZ></fA14><fA14 i1="02"><s1>Division of Anatomical Pathology, University of Cape Town/ Groote Schuur Hospital</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Cellular Pathology, Southampton University Hospitals NHS Trust</s1><s2>Southampton</s2><s3>GBR</s3><sZ>4 aut.</sZ><sZ>9 aut.</sZ></fA14><fA14 i1="04"><s1>Center for Colorectal Cancer, Research Institute & Hospital, National Cancer Center</s1><s2>Goyang</s2><s3>KOR</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Pathology, London Health Sciences Centre/ University of Western Ontario</s1><s2>London</s2><s3>CAN</s3><sZ>6 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Pathology, Western Infirmary</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Pathology, Hospital de Navarra</s1><s2>Pamplona</s2><s3>ESP</s3><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Pathology, Liverpool & Royal Prince Alfred Hospital, University of Western Sydney</s1><s2>Sydney</s2><s3>AUS</s3><sZ>10 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Diagnostic Sciences & Special Therapies, Pathology Unit, University of Padova</s1><s2>Padova</s2><s3>ITA</s3><sZ>12 aut.</sZ></fA14><fA14 i1="10"><s1>Department of Pathology, Sunnybrook Health Science Center/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>13 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Pathology, CHU Bordeaux</s1><s3>FRA</s3><sZ>14 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Pathology, University Health Network/University of Toronto</s1><s2>Toronto</s2><s3>CAN</s3><sZ>15 aut.</sZ><sZ>17 aut.</sZ><sZ>18 aut.</sZ></fA14><fA14 i1="13"><s1>Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital</s1><s2>Cheltenham</s2><s3>GBR</s3><sZ>16 aut.</sZ></fA14><fA20><s1>151-155</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>863</s2><s5>354000509751850040</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>21 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0158054</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Virchows Archiv</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>To ascertain the approach and degree of consensus of pathologists in the handling and regression grading of colorectal cancer resection specimens treated with neoadjuvant chemoradiation, a ten-part questionnaire was circulated to 18 gastrointestinal pathologists in eight countries. The questions were specific and addressed pertinent issues related to colorectal cancer with neoadjuvant chemoradiation. There is a lack of consensus on how to handle the specimen, number of sections taken, correlation with pre-and post-operative radiological imaging, and especially, regression grading schema employed. Consensus in the form of guidelines is required so that the pathological assessment of these specimens will provide clinically relevant information for patient management, irrespective of location.</s0></fC01><fC02 i1="01" i2="X"><s0>002B24O</s0></fC02><fC02 i1="02" i2="X"><s0>002B13B01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Cancer colorectal</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Colorectal cancer</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Cancer de colon y recto</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Surveillance</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Surveillance</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Vigilancia</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Enquête</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Survey</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Encuesta</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Résection 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sortKey="Bateman, Adrian" sort="Bateman, Adrian" uniqKey="Bateman A" first="Adrian" last="Bateman">Adrian Bateman</name><name sortKey="Duthie, Fraser" sort="Duthie, Fraser" uniqKey="Duthie F" first="Fraser" last="Duthie">Fraser Duthie</name><name sortKey="Gill, Pelvender" sort="Gill, Pelvender" uniqKey="Gill P" first="Pelvender" last="Gill">Pelvender Gill</name><name sortKey="Jaynes, Eleanor" sort="Jaynes, Eleanor" uniqKey="Jaynes E" first="Eleanor" last="Jaynes">Eleanor Jaynes</name><name sortKey="Lai Mun Wang" sort="Lai Mun Wang" uniqKey="Lai Mun Wang" last="Lai Mun Wang">LAI MUN WANG</name><name sortKey="Shepherd, Neil" sort="Shepherd, Neil" uniqKey="Shepherd N" first="Neil" last="Shepherd">Neil Shepherd</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Govender, Dhirendra" sort="Govender, Dhirendra" uniqKey="Govender D" first="Dhirendra" last="Govender">Dhirendra Govender</name></noRegion><name sortKey="Locketz, Michael" sort="Locketz, Michael" uniqKey="Locketz M" first="Michael" last="Locketz">Michael Locketz</name></country><country name="Corée du Sud"><noRegion><name sortKey="Hee Jin Chang" sort="Hee Jin Chang" uniqKey="Hee Jin Chang" last="Hee Jin Chang">HEE JIN CHANG</name></noRegion></country><country name="Canada"><region name="Angleterre"><name sortKey="Driman, David" sort="Driman, David" uniqKey="Driman D" first="David" last="Driman">David Driman</name></region><name sortKey="Rowsell, Corwyn" sort="Rowsell, Corwyn" uniqKey="Rowsell C" first="Corwyn" last="Rowsell">Corwyn Rowsell</name><name sortKey="Serra, Stefano" sort="Serra, Stefano" uniqKey="Serra S" first="Stefano" last="Serra">Stefano Serra</name><name sortKey="Szentgyorgyi, Eva" sort="Szentgyorgyi, Eva" uniqKey="Szentgyorgyi E" first="Eva" last="Szentgyorgyi">Eva Szentgyorgyi</name><name sortKey="Vajpeyi, Rajkumar" sort="Vajpeyi, Rajkumar" uniqKey="Vajpeyi R" first="Rajkumar" last="Vajpeyi">Rajkumar Vajpeyi</name></country><country name="Espagne"><noRegion><name sortKey="Gomez, Marisa" sort="Gomez, Marisa" uniqKey="Gomez M" first="Marisa" last="Gomez">Marisa Gomez</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Cheok Soon Lee" sort="Cheok Soon Lee" uniqKey="Cheok Soon Lee" last="Cheok Soon Lee">CHEOK SOON LEE</name></region></country><country name="Italie"><noRegion><name sortKey="Mescoli, Claudia" sort="Mescoli, Claudia" uniqKey="Mescoli C" first="Claudia" last="Mescoli">Claudia Mescoli</name></noRegion></country><country name="France"><noRegion><name sortKey="Rullier, Anne" sort="Rullier, Anne" uniqKey="Rullier A" first="Anne" last="Rullier">Anne Rullier</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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