The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.
Identifieur interne : 004D70 ( Ncbi/Merge ); précédent : 004D69; suivant : 004D71The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.
Auteurs : Roger S. Mcintyre [Canada] ; Michael W. Best [Canada] ; Christopher R. Bowie [Canada] ; Nicole E. Carmona [Canada] ; Danielle S. Cha [Canada] ; Yena Lee [Canada] ; Mehala Subramaniapillai [Canada] ; Rodrigo B. Mansur [Canada] ; Harry Barry [Irlande (pays)] ; Bernhard T. Baune [Australie] ; Larry Culpepper [États-Unis] ; Philippe Fossati [France] ; Tracy L. Greer [États-Unis] ; Catherine Harmer [Royaume-Uni] ; Esther Klag [Royaume-Uni] ; Raymond W. Lam [Canada] ; Hans-Ulrich Wittchen [Allemagne] ; John Harrison [Pays-Bas]Source :
- The Journal of clinical psychiatry [ 1555-2101 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Diagnostic assisté par ordinateur, Dépistage systématique, Femelle, Humains, Jeune adulte, Mâle, Psychométrie (), Reproductibilité des résultats, Récidive, Sujet âgé, Tests neuropsychologiques (), Trouble dépressif majeur (diagnostic), Trouble dépressif majeur (psychologie), Trouble dépressif majeur (épidémiologie), Troubles de la cognition (diagnostic), Troubles de la cognition (psychologie), Troubles de la cognition (épidémiologie), Valeurs de référence.
- MESH :
- diagnostic : Trouble dépressif majeur, Troubles de la cognition.
- psychologie : Trouble dépressif majeur, Troubles de la cognition.
- épidémiologie : Trouble dépressif majeur, Troubles de la cognition.
- Adolescent, Adulte, Adulte d'âge moyen, Diagnostic assisté par ordinateur, Dépistage systématique, Femelle, Humains, Jeune adulte, Mâle, Psychométrie, Reproductibilité des résultats, Récidive, Sujet âgé, Tests neuropsychologiques, Valeurs de référence.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Cognition Disorders (psychology), Depressive Disorder, Major (diagnosis), Depressive Disorder, Major (epidemiology), Depressive Disorder, Major (psychology), Diagnosis, Computer-Assisted, Female, Humans, Male, Mass Screening, Middle Aged, Neuropsychological Tests (statistics & numerical data), Psychometrics (statistics & numerical data), Recurrence, Reference Values, Reproducibility of Results, Young Adult.
- MESH :
- diagnosis : Cognition Disorders, Depressive Disorder, Major.
- epidemiology : Cognition Disorders, Depressive Disorder, Major.
- psychology : Cognition Disorders, Depressive Disorder, Major.
- statistics & numerical data : Neuropsychological Tests, Psychometrics.
- Adolescent, Adult, Aged, Diagnosis, Computer-Assisted, Female, Humans, Male, Mass Screening, Middle Aged, Recurrence, Reference Values, Reproducibility of Results, Young Adult.
Abstract
To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).
DOI: 10.4088/JCP.16m11329
PubMed: 28858441
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000932
- to stream PubMed, to step Curation: 000929
- to stream PubMed, to step Checkpoint: 000929
Links to Exploration step
pubmed:28858441Le document en format XML
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<author><name sortKey="Harrison, John" sort="Harrison, John" uniqKey="Harrison J" first="John" last="Harrison">John Harrison</name>
<affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center, VU Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Alzheimer Center, VU Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
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<series><title level="j">The Journal of clinical psychiatry</title>
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<imprint><date when="2017" type="published">2017</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (epidemiology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Depressive Disorder, Major (diagnosis)</term>
<term>Depressive Disorder, Major (epidemiology)</term>
<term>Depressive Disorder, Major (psychology)</term>
<term>Diagnosis, Computer-Assisted</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mass Screening</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests (statistics & numerical data)</term>
<term>Psychometrics (statistics & numerical data)</term>
<term>Recurrence</term>
<term>Reference Values</term>
<term>Reproducibility of Results</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Diagnostic assisté par ordinateur</term>
<term>Dépistage systématique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Psychométrie ()</term>
<term>Reproductibilité des résultats</term>
<term>Récidive</term>
<term>Sujet âgé</term>
<term>Tests neuropsychologiques ()</term>
<term>Trouble dépressif majeur (diagnostic)</term>
<term>Trouble dépressif majeur (psychologie)</term>
<term>Trouble dépressif majeur (épidémiologie)</term>
<term>Troubles de la cognition (diagnostic)</term>
<term>Troubles de la cognition (psychologie)</term>
<term>Troubles de la cognition (épidémiologie)</term>
<term>Valeurs de référence</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
<term>Depressive Disorder, Major</term>
</keywords>
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<term>Troubles de la cognition</term>
</keywords>
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<term>Depressive Disorder, Major</term>
</keywords>
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<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term>
<term>Depressive Disorder, Major</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neuropsychological Tests</term>
<term>Psychometrics</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Trouble dépressif majeur</term>
<term>Troubles de la cognition</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Diagnosis, Computer-Assisted</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mass Screening</term>
<term>Middle Aged</term>
<term>Recurrence</term>
<term>Reference Values</term>
<term>Reproducibility of Results</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
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<term>Dépistage systématique</term>
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<front><div type="abstract" xml:lang="en">To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28858441</PMID>
<DateCreated><Year>2017</Year>
<Month>08</Month>
<Day>31</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1555-2101</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>78</Volume>
<Issue>7</Issue>
<PubDate><Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of clinical psychiatry</Title>
<ISOAbbreviation>J Clin Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.</ArticleTitle>
<Pagination><MedlinePgn>873-881</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4088/JCP.16m11329</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">16m11329</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P < .001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov identifier: NCT02508493.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McIntyre</LastName>
<ForeName>Roger S</ForeName>
<Initials>RS</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry and Pharmacology, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, Brain and Cognition Discovery Foundation, 399 Bathurst St, Toronto, ON, Canada M5T 2S8. Roger.McIntyre@uhn.ca.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Brain and Cognition Discovery Foundation (BCDF), Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Medical Science, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Best</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo><Affiliation>Department of Psychology, Queen's University, Kingston, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bowie</LastName>
<ForeName>Christopher R</ForeName>
<Initials>CR</Initials>
<AffiliationInfo><Affiliation>Department of Psychology, Queen's University, Kingston, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centre for Addiction and Mental Health, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carmona</LastName>
<ForeName>Nicole E</ForeName>
<Initials>NE</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cha</LastName>
<ForeName>Danielle S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, University of Queensland, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Yena</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Medical Science, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Subramaniapillai</LastName>
<ForeName>Mehala</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mansur</LastName>
<ForeName>Rodrigo B</ForeName>
<Initials>RB</Initials>
<AffiliationInfo><Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barry</LastName>
<ForeName>Harry</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Stoneylane Clinic Drogheda, Co Louth, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baune</LastName>
<ForeName>Bernhard T</ForeName>
<Initials>BT</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Adelaide, Adelaide, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Culpepper</LastName>
<ForeName>Larry</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Department of Family Medicine, Boston University, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fossati</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle, ICM, Social and Affective Neuroscience (SAN) Team, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Greer</LastName>
<ForeName>Tracy L</ForeName>
<Initials>TL</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harmer</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Klag</LastName>
<ForeName>Esther</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Private practice, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lam</LastName>
<ForeName>Raymond W</ForeName>
<Initials>RW</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wittchen</LastName>
<ForeName>Hans-Ulrich</ForeName>
<Initials>HU</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Psychology and Psychotherapy and Centre of Clinical Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harrison</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Alzheimer Center, VU Medical Center, Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Metis Cognition Ltd, Warminster, United Kingdom.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>IoPPN, King's College, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList><AccessionNumber>NCT02508493</AccessionNumber>
</AccessionNumberList>
</DataBank>
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<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<MedlineJournalInfo><Country>United States</Country>
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<NlmUniqueID>7801243</NlmUniqueID>
<ISSNLinking>0160-6689</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
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</MeshHeading>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
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<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011594" MajorTopicYN="N">Psychometrics</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D012008" MajorTopicYN="N">Recurrence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>11</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>06</Month>
<Day>09</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2017</Year>
<Month>9</Month>
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<Hour>6</Hour>
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<li>Australie</li>
<li>Canada</li>
<li>France</li>
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<li>Royaume-Uni</li>
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<orgName><li>Université de Toronto</li>
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<name sortKey="Carmona, Nicole E" sort="Carmona, Nicole E" uniqKey="Carmona N" first="Nicole E" last="Carmona">Nicole E. Carmona</name>
<name sortKey="Cha, Danielle S" sort="Cha, Danielle S" uniqKey="Cha D" first="Danielle S" last="Cha">Danielle S. Cha</name>
<name sortKey="Lam, Raymond W" sort="Lam, Raymond W" uniqKey="Lam R" first="Raymond W" last="Lam">Raymond W. Lam</name>
<name sortKey="Lee, Yena" sort="Lee, Yena" uniqKey="Lee Y" first="Yena" last="Lee">Yena Lee</name>
<name sortKey="Mansur, Rodrigo B" sort="Mansur, Rodrigo B" uniqKey="Mansur R" first="Rodrigo B" last="Mansur">Rodrigo B. Mansur</name>
<name sortKey="Subramaniapillai, Mehala" sort="Subramaniapillai, Mehala" uniqKey="Subramaniapillai M" first="Mehala" last="Subramaniapillai">Mehala Subramaniapillai</name>
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<country name="Australie"><noRegion><name sortKey="Baune, Bernhard T" sort="Baune, Bernhard T" uniqKey="Baune B" first="Bernhard T" last="Baune">Bernhard T. Baune</name>
</noRegion>
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<country name="États-Unis"><region name="Massachusetts"><name sortKey="Culpepper, Larry" sort="Culpepper, Larry" uniqKey="Culpepper L" first="Larry" last="Culpepper">Larry Culpepper</name>
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<name sortKey="Greer, Tracy L" sort="Greer, Tracy L" uniqKey="Greer T" first="Tracy L" last="Greer">Tracy L. Greer</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Fossati, Philippe" sort="Fossati, Philippe" uniqKey="Fossati P" first="Philippe" last="Fossati">Philippe Fossati</name>
</region>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Harmer, Catherine" sort="Harmer, Catherine" uniqKey="Harmer C" first="Catherine" last="Harmer">Catherine Harmer</name>
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<country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Wittchen, Hans Ulrich" sort="Wittchen, Hans Ulrich" uniqKey="Wittchen H" first="Hans-Ulrich" last="Wittchen">Hans-Ulrich Wittchen</name>
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