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The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.

Identifieur interne : 000929 ( PubMed/Curation ); précédent : 000928; suivant : 000930

The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.

Auteurs : Roger S. Mcintyre [Canada] ; Michael W. Best [Canada] ; Christopher R. Bowie [Canada] ; Nicole E. Carmona [Canada] ; Danielle S. Cha [Canada] ; Yena Lee [Canada] ; Mehala Subramaniapillai [Canada] ; Rodrigo B. Mansur [Canada] ; Harry Barry [Irlande (pays)] ; Bernhard T. Baune [Australie] ; Larry Culpepper [États-Unis] ; Philippe Fossati [France] ; Tracy L. Greer [États-Unis] ; Catherine Harmer [Royaume-Uni] ; Esther Klag [Royaume-Uni] ; Raymond W. Lam [Canada] ; Hans-Ulrich Wittchen [Allemagne] ; John Harrison [Pays-Bas]

Source :

RBID : pubmed:28858441

Descripteurs français

English descriptors

Abstract

To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).

DOI: 10.4088/JCP.16m11329
PubMed: 28858441

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pubmed:28858441

Le document en format XML

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<nlm:affiliation>Stoneylane Clinic Drogheda, Co Louth, Ireland.</nlm:affiliation>
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<nlm:affiliation>Department of Psychiatry, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
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<name sortKey="Fossati, Philippe" sort="Fossati, Philippe" uniqKey="Fossati P" first="Philippe" last="Fossati">Philippe Fossati</name>
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<term>Tests neuropsychologiques</term>
<term>Valeurs de référence</term>
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<div type="abstract" xml:lang="en">To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Status="MEDLINE" Owner="NLM">
<PMID Version="1">28858441</PMID>
<DateCreated>
<Year>2017</Year>
<Month>08</Month>
<Day>31</Day>
</DateCreated>
<DateCompleted>
<Year>2017</Year>
<Month>09</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>09</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1555-2101</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>78</Volume>
<Issue>7</Issue>
<PubDate>
<Year>2017</Year>
<Month>Jul</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of clinical psychiatry</Title>
<ISOAbbreviation>J Clin Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.</ArticleTitle>
<Pagination>
<MedlinePgn>873-881</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.4088/JCP.16m11329</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">16m11329</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P < .001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment.</AbstractText>
<AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov identifier: NCT02508493.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>McIntyre</LastName>
<ForeName>Roger S</ForeName>
<Initials>RS</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry and Pharmacology, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, Brain and Cognition Discovery Foundation, 399 Bathurst St, Toronto, ON, Canada M5T 2S8. Roger.McIntyre@uhn.ca.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Brain and Cognition Discovery Foundation (BCDF), Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Psychiatry, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Department of Pharmacology, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Institute of Medical Science, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Best</LastName>
<ForeName>Michael W</ForeName>
<Initials>MW</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychology, Queen's University, Kingston, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bowie</LastName>
<ForeName>Christopher R</ForeName>
<Initials>CR</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychology, Queen's University, Kingston, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Centre for Addiction and Mental Health, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Carmona</LastName>
<ForeName>Nicole E</ForeName>
<Initials>NE</Initials>
<AffiliationInfo>
<Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cha</LastName>
<ForeName>Danielle S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo>
<Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Faculty of Medicine, University of Queensland, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Yena</ForeName>
<Initials>Y</Initials>
<AffiliationInfo>
<Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Institute of Medical Science, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Subramaniapillai</LastName>
<ForeName>Mehala</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mansur</LastName>
<ForeName>Rodrigo B</ForeName>
<Initials>RB</Initials>
<AffiliationInfo>
<Affiliation>Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Barry</LastName>
<ForeName>Harry</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Stoneylane Clinic Drogheda, Co Louth, Ireland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Baune</LastName>
<ForeName>Bernhard T</ForeName>
<Initials>BT</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry, University of Adelaide, Adelaide, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Culpepper</LastName>
<ForeName>Larry</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Department of Family Medicine, Boston University, Boston, Massachusetts, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Fossati</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle, ICM, Social and Affective Neuroscience (SAN) Team, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Greer</LastName>
<ForeName>Tracy L</ForeName>
<Initials>TL</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Harmer</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>University Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Klag</LastName>
<ForeName>Esther</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Private practice, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lam</LastName>
<ForeName>Raymond W</ForeName>
<Initials>RW</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wittchen</LastName>
<ForeName>Hans-Ulrich</ForeName>
<Initials>HU</Initials>
<AffiliationInfo>
<Affiliation>Institute of Clinical Psychology and Psychotherapy and Centre of Clinical Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Harrison</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Alzheimer Center, VU Medical Center, Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Metis Cognition Ltd, Warminster, United Kingdom.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>IoPPN, King's College, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
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<DataBankName>ClinicalTrials.gov</DataBankName>
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<AccessionNumber>NCT02508493</AccessionNumber>
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<PublicationType UI="D016428">Journal Article</PublicationType>
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<Country>United States</Country>
<MedlineTA>J Clin Psychiatry</MedlineTA>
<NlmUniqueID>7801243</NlmUniqueID>
<ISSNLinking>0160-6689</ISSNLinking>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D003072" MajorTopicYN="N">Cognition Disorders</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D003865" MajorTopicYN="N">Depressive Disorder, Major</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
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<MeshHeading>
<DescriptorName UI="D003936" MajorTopicYN="Y">Diagnosis, Computer-Assisted</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D008403" MajorTopicYN="Y">Mass Screening</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
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<MeshHeading>
<DescriptorName UI="D011594" MajorTopicYN="N">Psychometrics</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
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<DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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<PubMedPubDate PubStatus="received">
<Year>2016</Year>
<Month>11</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2017</Year>
<Month>06</Month>
<Day>09</Day>
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