Week 96 results of the randomized, multicentre Maraviroc Switch (MARCH) study.
Identifieur interne : 004B14 ( Ncbi/Merge ); précédent : 004B13; suivant : 004B15Week 96 results of the randomized, multicentre Maraviroc Switch (MARCH) study.
Auteurs : S L Pett [Australie] ; J. Amin [Australie] ; A. Horban [Pologne] ; J. Andrade-Villanueva [Mexique] ; M. Losso [Argentine] ; N. Porteiro [Argentine] ; J S Madero [Mexique] ; W. Belloso [Argentine] ; E. Tu [Australie] ; D. Silk [Australie] ; A. Kelleher [Australie] ; R. Harrigan [Canada] ; A. Clark [Royaume-Uni] ; W. Sugiura [Japon] ; M. Wolff [Chili] ; J. Gill [Canada] ; J. Gatell [Espagne] ; A. Clarke [Royaume-Uni] ; K. Ruxrungtham ; T. Prazuck [France] ; R. Kaiser [Allemagne] ; I. Woolley [Australie] ; J. Alberto Arnaiz [Espagne] ; D. Cooper [Australie] ; J K Rockstroh [Allemagne] ; P. Mallon [Irlande (pays)] ; S. Emery [Australie]Source :
- HIV medicine [ 1468-1293 ] ; 2017.
Abstract
The Maraviroc Switch (MARCH) study week 48 data demonstrated that maraviroc, a chemokine receptor-5 (CCR5) inhibitor, was a safe and effective switch for the ritonavir-boosted protease inhibitor (PI/r) component of a two nucleos(t)ide reverse transcriptase inhibitor [N(t)RTI] plus PI/r-based antiretroviral regimen in patients with R5-tropic virus. Here we report the durability of this finding.
DOI: 10.1111/hiv.12532
PubMed: 28703491
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Belloso</name><affiliation wicri:level="1"><nlm:affiliation>Fundación IBIS CICAL, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación IBIS CICAL, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Tu, E" sort="Tu, E" uniqKey="Tu E" first="E" last="Tu">E. Tu</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Silk, D" sort="Silk, D" uniqKey="Silk D" first="D" last="Silk">D. Silk</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Kelleher, A" sort="Kelleher, A" uniqKey="Kelleher A" first="A" last="Kelleher">A. Kelleher</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Harrigan, R" sort="Harrigan, R" uniqKey="Harrigan R" first="R" last="Harrigan">R. Harrigan</name><affiliation wicri:level="1"><nlm:affiliation>BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>BC Centre for Excellence in HIV/AIDS, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A" last="Clark">A. Clark</name><affiliation wicri:level="3"><nlm:affiliation>ViiV Healthcare Ltd, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>ViiV Healthcare Ltd, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sugiura, W" sort="Sugiura, W" uniqKey="Sugiura W" first="W" last="Sugiura">W. Sugiura</name><affiliation wicri:level="1"><nlm:affiliation>Nagoya Medical Centre, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya Medical Centre, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Wolff, M" sort="Wolff, M" uniqKey="Wolff M" first="M" last="Wolff">M. Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Fundacion Arriaran, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Fundacion Arriaran, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Gill, J" sort="Gill, J" uniqKey="Gill J" first="J" last="Gill">J. Gill</name><affiliation wicri:level="1"><nlm:affiliation>Southern Alberta Clinic, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Southern Alberta Clinic, Calgary, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Gatell, J" sort="Gatell, J" uniqKey="Gatell J" first="J" last="Gatell">J. Gatell</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A" last="Clarke">A. Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton & Sussex University Hospitals NHS Trust, Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Ruxrungtham, K" sort="Ruxrungtham, K" uniqKey="Ruxrungtham K" first="K" last="Ruxrungtham">K. Ruxrungtham</name><affiliation><nlm:affiliation>HIV-NAT, Thai Red Cross AIDS Research Center.</nlm:affiliation><wicri:noCountry code="subField">Thai Red Cross AIDS Research Center</wicri:noCountry></affiliation></author><author><name sortKey="Prazuck, T" sort="Prazuck, T" uniqKey="Prazuck T" first="T" last="Prazuck">T. Prazuck</name><affiliation wicri:level="3"><nlm:affiliation>Orleans Hospital (CHR Orleans La Source), Orleans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Orleans Hospital (CHR Orleans La Source), Orleans</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Kaiser, R" sort="Kaiser, R" uniqKey="Kaiser R" first="R" last="Kaiser">R. Kaiser</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Woolley, I" sort="Woolley, I" uniqKey="Woolley I" first="I" last="Woolley">I. Woolley</name><affiliation wicri:level="1"><nlm:affiliation>Monash Medical Centre and Monash University, Melbourne, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Medical Centre and Monash University, Melbourne, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Alberto Arnaiz, J" sort="Alberto Arnaiz, J" uniqKey="Alberto Arnaiz J" first="J" last="Alberto Arnaiz">J. Alberto Arnaiz</name><affiliation wicri:level="3"><nlm:affiliation>Fundacion Clinic Spain CTU, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundacion Clinic Spain CTU, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cooper, D" sort="Cooper, D" uniqKey="Cooper D" first="D" last="Cooper">D. Cooper</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Rockstroh, J K" sort="Rockstroh, J K" uniqKey="Rockstroh J" first="J K" last="Rockstroh">J K Rockstroh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine I, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine I, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Mallon, P" sort="Mallon, P" uniqKey="Mallon P" first="P" last="Mallon">P. Mallon</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine, University College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Emery, S" sort="Emery, S" uniqKey="Emery S" first="S" last="Emery">S. Emery</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28703491</idno><idno type="pmid">28703491</idno><idno type="doi">10.1111/hiv.12532</idno><idno type="wicri:Area/PubMed/Corpus">000876</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000876</idno><idno type="wicri:Area/PubMed/Curation">000873</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000873</idno><idno type="wicri:Area/PubMed/Checkpoint">000873</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000873</idno><idno type="wicri:Area/Ncbi/Merge">004B14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Week 96 results of the randomized, multicentre Maraviroc Switch (MARCH) study.</title><author><name sortKey="Pett, S L" sort="Pett, S L" uniqKey="Pett S" first="S L" last="Pett">S L Pett</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Amin, J" sort="Amin, J" uniqKey="Amin J" first="J" last="Amin">J. Amin</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Horban, A" sort="Horban, A" uniqKey="Horban A" first="A" last="Horban">A. Horban</name><affiliation wicri:level="1"><nlm:affiliation>Wojewodzki Szpital Zakazny Centre for AIDS therapy and Diagnosis, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Wojewodzki Szpital Zakazny Centre for AIDS therapy and Diagnosis, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Andrade Villanueva, J" sort="Andrade Villanueva, J" uniqKey="Andrade Villanueva J" first="J" last="Andrade-Villanueva">J. Andrade-Villanueva</name><affiliation wicri:level="1"><nlm:affiliation>Hospital Civil de Guadalajara "Fray Antonio Alcalde", Jalisco, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Hospital Civil de Guadalajara "Fray Antonio Alcalde", Jalisco</wicri:regionArea><wicri:noRegion>Jalisco</wicri:noRegion></affiliation></author><author><name sortKey="Losso, M" sort="Losso, M" uniqKey="Losso M" first="M" last="Losso">M. Losso</name><affiliation wicri:level="1"><nlm:affiliation>Hospital General de Agudos J M Ramos Mejia, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Hospital General de Agudos J M Ramos Mejia, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Porteiro, N" sort="Porteiro, N" uniqKey="Porteiro N" first="N" last="Porteiro">N. Porteiro</name><affiliation wicri:level="1"><nlm:affiliation>Fundación IDEAA, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación IDEAA, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Madero, J S" sort="Madero, J S" uniqKey="Madero J" first="J S" last="Madero">J S Madero</name><affiliation wicri:level="1"><nlm:affiliation>Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran, Tlalpan, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran, Tlalpan</wicri:regionArea><wicri:noRegion>Tlalpan</wicri:noRegion></affiliation></author><author><name sortKey="Belloso, W" sort="Belloso, W" uniqKey="Belloso W" first="W" last="Belloso">W. Belloso</name><affiliation wicri:level="1"><nlm:affiliation>Fundación IBIS CICAL, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Fundación IBIS CICAL, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Tu, E" sort="Tu, E" uniqKey="Tu E" first="E" last="Tu">E. Tu</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Silk, D" sort="Silk, D" uniqKey="Silk D" first="D" last="Silk">D. Silk</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Kelleher, A" sort="Kelleher, A" uniqKey="Kelleher A" first="A" last="Kelleher">A. Kelleher</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Harrigan, R" sort="Harrigan, R" uniqKey="Harrigan R" first="R" last="Harrigan">R. Harrigan</name><affiliation wicri:level="1"><nlm:affiliation>BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>BC Centre for Excellence in HIV/AIDS, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A" last="Clark">A. Clark</name><affiliation wicri:level="3"><nlm:affiliation>ViiV Healthcare Ltd, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>ViiV Healthcare Ltd, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sugiura, W" sort="Sugiura, W" uniqKey="Sugiura W" first="W" last="Sugiura">W. Sugiura</name><affiliation wicri:level="1"><nlm:affiliation>Nagoya Medical Centre, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya Medical Centre, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Wolff, M" sort="Wolff, M" uniqKey="Wolff M" first="M" last="Wolff">M. Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Fundacion Arriaran, Santiago, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Fundacion Arriaran, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Gill, J" sort="Gill, J" uniqKey="Gill J" first="J" last="Gill">J. Gill</name><affiliation wicri:level="1"><nlm:affiliation>Southern Alberta Clinic, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Southern Alberta Clinic, Calgary, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Gatell, J" sort="Gatell, J" uniqKey="Gatell J" first="J" last="Gatell">J. Gatell</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Clinic de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinic de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Clarke, A" sort="Clarke, A" uniqKey="Clarke A" first="A" last="Clarke">A. Clarke</name><affiliation wicri:level="1"><nlm:affiliation>Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton & Sussex University Hospitals NHS Trust, Brighton</wicri:regionArea><wicri:noRegion>Brighton</wicri:noRegion></affiliation></author><author><name sortKey="Ruxrungtham, K" sort="Ruxrungtham, K" uniqKey="Ruxrungtham K" first="K" last="Ruxrungtham">K. Ruxrungtham</name><affiliation><nlm:affiliation>HIV-NAT, Thai Red Cross AIDS Research Center.</nlm:affiliation><wicri:noCountry code="subField">Thai Red Cross AIDS Research Center</wicri:noCountry></affiliation></author><author><name sortKey="Prazuck, T" sort="Prazuck, T" uniqKey="Prazuck T" first="T" last="Prazuck">T. Prazuck</name><affiliation wicri:level="3"><nlm:affiliation>Orleans Hospital (CHR Orleans La Source), Orleans, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Orleans Hospital (CHR Orleans La Source), Orleans</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Kaiser, R" sort="Kaiser, R" uniqKey="Kaiser R" first="R" last="Kaiser">R. Kaiser</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Woolley, I" sort="Woolley, I" uniqKey="Woolley I" first="I" last="Woolley">I. Woolley</name><affiliation wicri:level="1"><nlm:affiliation>Monash Medical Centre and Monash University, Melbourne, Vic, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Medical Centre and Monash University, Melbourne, Vic</wicri:regionArea><wicri:noRegion>Vic</wicri:noRegion></affiliation></author><author><name sortKey="Alberto Arnaiz, J" sort="Alberto Arnaiz, J" uniqKey="Alberto Arnaiz J" first="J" last="Alberto Arnaiz">J. Alberto Arnaiz</name><affiliation wicri:level="3"><nlm:affiliation>Fundacion Clinic Spain CTU, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundacion Clinic Spain CTU, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cooper, D" sort="Cooper, D" uniqKey="Cooper D" first="D" last="Cooper">D. Cooper</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Rockstroh, J K" sort="Rockstroh, J K" uniqKey="Rockstroh J" first="J K" last="Rockstroh">J K Rockstroh</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine I, University Hospital Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine I, University Hospital Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Mallon, P" sort="Mallon, P" uniqKey="Mallon P" first="P" last="Mallon">P. Mallon</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University College Dublin, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>School of Medicine, University College Dublin, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Emery, S" sort="Emery, S" uniqKey="Emery S" first="S" last="Emery">S. Emery</name><affiliation wicri:level="1"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The Kirby Institute, UNSW Australia, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">HIV medicine</title><idno type="eISSN">1468-1293</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Maraviroc Switch (MARCH) study week 48 data demonstrated that maraviroc, a chemokine receptor-5 (CCR5) inhibitor, was a safe and effective switch for the ritonavir-boosted protease inhibitor (PI/r) component of a two nucleos(t)ide reverse transcriptase inhibitor [N(t)RTI] plus PI/r-based antiretroviral regimen in patients with R5-tropic virus. Here we report the durability of this finding.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">28703491</PMID><DateCreated><Year>2017</Year><Month>07</Month><Day>13</Day></DateCreated><DateRevised><Year>2017</Year><Month>07</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-1293</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2017</Year><Month>Jul</Month><Day>13</Day></PubDate></JournalIssue><Title>HIV medicine</Title><ISOAbbreviation>HIV Med.</ISOAbbreviation></Journal><ArticleTitle>Week 96 results of the randomized, multicentre Maraviroc Switch (MARCH) study.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/hiv.12532</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The Maraviroc Switch (MARCH) study week 48 data demonstrated that maraviroc, a chemokine receptor-5 (CCR5) inhibitor, was a safe and effective switch for the ritonavir-boosted protease inhibitor (PI/r) component of a two nucleos(t)ide reverse transcriptase inhibitor [N(t)RTI] plus PI/r-based antiretroviral regimen in patients with R5-tropic virus. Here we report the durability of this finding.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">MARCH, an international, multicentre, randomized, 96-week open-label switch study, enrolled HIV-1-infected adults with R5-tropic virus who were stable (> 24 weeks) and virologically suppressed [plasma viral load (pVL) < 50 HIV-1 RNA copies/mL]. Participants were randomized to continue their current PI/r-based regimen (PI/r) or to switch to MVC plus two N(t)RTIs (MVC) (1:2 randomization). The primary endpoint was the difference in the proportion with pVL < 200 copies/mL at 96 weeks. The switch arm was defined as noninferior if the lower limit of the 95% confidence interval (CI) for the difference was < -12% in the intention-to-treat (ITT) population. Safety endpoints (the difference in the mean change from baseline or a comparison of proportions) were analysed as key secondary endpoints.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Eighty-two (PI/r) and 156 (MVC) participants were randomized and included in the ITT analysis; 71 (87%) and 130 (83%) were in follow-up and on therapy at week 96. At week 96, 89.0% and 90.4% in the PI/r and MVC arms, respectively, had pVL < 50 copies/mL (95% CI -6.6, 10.2). Moreover, in those switching away from PI/r, there were significant reductions in mean total cholesterol (differences 0.31 mmol/L; P = 0.02) and triglycerides (difference 0.44 mmol/L; P < 0.001). Changes in CD4 T-cell count, renal function, and serious and nonserious adverse events were similar in the two arms.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">MVC as a switch for a PI/r is safe and effective at maintaining virological suppression while having significant lipid benefits over 96 weeks.</AbstractText><CopyrightInformation>© 2017 British HIV Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pett</LastName><ForeName>S L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institutes of Clinical Trials and Methodology, University College London, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Research Group, Infection and Population Health, Institute for Global Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horban</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wojewodzki Szpital Zakazny Centre for AIDS therapy and Diagnosis, Warsaw, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrade-Villanueva</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Civil de Guadalajara "Fray Antonio Alcalde", Jalisco, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Losso</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Hospital General de Agudos J M Ramos Mejia, Buenos Aires, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Fundación IBIS CICAL, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porteiro</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Fundación IDEAA, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madero</LastName><ForeName>J S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Instituto Nacional de Ciencias Medicas y Nutriciòn Salvador Zubiran, Tlalpan, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belloso</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Fundación IBIS CICAL, Buenos Aires, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silk</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelleher</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>St Vincent's Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrigan</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>BC Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>ViiV Healthcare Ltd, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sugiura</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Nagoya Medical Centre, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolff</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Fundacion Arriaran, Santiago, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gill</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Southern Alberta Clinic, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gatell</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hospital Clinic de Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarke</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruxrungtham</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>HIV-NAT, Thai Red Cross AIDS Research Center.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chulalongkorn University, Bangkok, Thailand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prazuck</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Orleans Hospital (CHR Orleans La Source), Orleans, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaiser</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institut für Virologie, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woolley</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Monash Medical Centre and Monash University, Melbourne, Vic, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alberto Arnaiz</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fundacion Clinic Spain CTU, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>St Vincent's Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rockstroh</LastName><ForeName>J K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Medicine I, University Hospital Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mallon</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>School of Medicine, University College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Emery</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Kirby Institute, UNSW Australia, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, The University of Queensland, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>MARCH study group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>HIV Med</MedlineTA><NlmUniqueID>100897392</NlmUniqueID><ISSNLinking>1464-2662</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">HIV-1</Keyword><Keyword MajorTopicYN="N">maraviroc</Keyword><Keyword MajorTopicYN="N">protease inhibitor</Keyword><Keyword MajorTopicYN="N">switch</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Amin</LastName><ForeName>Janaki</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Belloso</LastName><ForeName>Waldo</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clark</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Clarke</LastName><ForeName>Amanda</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cooper</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Emery</LastName><ForeName>Sean</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fisher</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gatell</LastName><ForeName>Jose</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gill</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Horban</LastName><ForeName>Andrejz</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kaiser</LastName><ForeName>Rolf</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kelleher</LastName><ForeName>Anthony</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Losso</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Madero</LastName><ForeName>Juan Sierra</ForeName><Initials>JS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pett</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prazuck</LastName><ForeName>Thierry</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rockstroh</LastName><ForeName>Juergen</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruxrungtham</LastName><ForeName>Kiat</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stellbrink</LastName><ForeName>Jurgen</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sugiura</LastName><ForeName>Wataru</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wolff</LastName><ForeName>Marcelo J</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Woolley</LastName><ForeName>Ian</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Merlin</LastName><ForeName>Kate</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yeung</LastName><ForeName>Julie</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fsadni</LastName><ForeName>Bertha</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marks</LastName><ForeName>Kat</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Kazuo</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rismanto</LastName><ForeName>Nick</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Salomon</LastName><ForeName>Horacio</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rubio</LastName><ForeName>Andrea E</ForeName><Initials>AE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chibo</LastName><ForeName>Doris</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Birch</LastName><ForeName>Chris</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Harrigan</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Swenson</LastName><ForeName>Luke</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chan</LastName><ForeName>Dennison</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Berg</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator 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ValidYN="Y"><LastName>Avila</LastName><ForeName>Santiago</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sirivichayakul</LastName><ForeName>Sunee</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Naphassanant</LastName><ForeName>May</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ubolyam</LastName><ForeName>Sasiwimol</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kaye</LastName><ForeName>Steve</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Land</LastName><ForeName>Sally</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Walker</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Haubrich</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>DeJesus</LastName><ForeName>Edwin</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Silk</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Berthon-Jones</LastName><ForeName>Nisha</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Espinosa</LastName><ForeName>Natalie</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Courtney-Vega</LastName><ForeName>Kymme</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Absar</LastName><ForeName>Noorul</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Haskelberg</LastName><ForeName>Hila</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robson</LastName><ForeName>Rose</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Donaldson</LastName><ForeName>Anna</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guelman</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gambardella</LastName><ForeName>Luciana</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Valdovinos</LastName><ForeName>Mariana</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arnaiz</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beleta</LastName><ForeName>Helena</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramos</LastName><ForeName>Nuria</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Targa</LastName><ForeName>Marta</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Späth</LastName><ForeName>Brigitta</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boesecke</LastName><ForeName>Christoph</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Engelhardt</LastName><ForeName>Angelika</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perry</LastName><ForeName>Nicky</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beckthold</LastName><ForeName>Brenda</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Drummond</LastName><ForeName>Fraser</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lefevre</LastName><ForeName>Eric</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Corr</LastName><ForeName>Sharon</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grant</LastName><ForeName>Carol</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lupo</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Peroni</LastName><ForeName>Luciana</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sanchez</LastName><ForeName>Marisa</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>De Paz Sierra</LastName><ForeName>Mariana</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Viloria</LastName><ForeName>Guillermo</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parlante</LastName><ForeName>Angel</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bissio</LastName><ForeName>Emiliano</ForeName><Initials>E</Initials></Investigator><Investigator 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