Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis.
Identifieur interne : 000873 ( PubMed/Checkpoint ); précédent : 000872; suivant : 000874Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis.
Auteurs : Faizan Khan [Canada] ; Alvi Rahman [Canada] ; Marc Carrier [Canada] ; Clive Kearon [Canada] ; Sam Schulman [Canada] ; Francis Couturaud [France] ; Paolo Prandoni [Italie] ; Sabine Eichinger [Autriche] ; Cecilia Becattini [Italie] ; Giancarlo Agnelli [Italie] ; Harry R. Büller [Pays-Bas] ; Timothy A. Brighton [Australie] ; Gualtiero Palareti [Italie] ; Laurent Pinede [France] ; Elham Sabri [Canada] ; Brian Hutton [Canada] ; George A. Wells [Canada] ; Marc A. Rodger [Canada]Source :
- BMJ open [ 2044-6055 ] ; 2017.
Abstract
For patients with a first unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is a crucial clinical dilemma which has yet to be resolved. The decision to stop anticoagulant therapy (AT) after the initial 3-6 months or to continue AT indefinitely, is primarily governed by the long-term risk of recurrence when treatment is discontinued. This risk however, is not well established, hindering decision making.
DOI: 10.1136/bmjopen-2017-016950
PubMed: 28939565
Affiliations:
- Australie, Autriche, Canada, France, Italie, Pays-Bas
- Auvergne-Rhône-Alpes, Hollande-Septentrionale, Nouvelle-Galles du Sud, Ontario, Rhône-Alpes, Région Bretagne, Vienne (Autriche)
- Amsterdam, Brest, Hamilton (Ontario), Lyon, Sydney, Vienne (Autriche)
- Université McMaster
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of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Carrier, Marc" sort="Carrier, Marc" uniqKey="Carrier M" first="Marc" last="Carrier">Marc Carrier</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kearon, Clive" sort="Kearon, Clive" uniqKey="Kearon C" first="Clive" last="Kearon">Clive Kearon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName 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Medicine and Chest Diseases, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departmentof Internal Medicine and Chest Diseases, Brest University Hospital, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Prandoni, Paolo" sort="Prandoni, Paolo" uniqKey="Prandoni P" first="Paolo" last="Prandoni">Paolo Prandoni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, Vascular Medicine Unit, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cardiovascular Sciences, Vascular Medicine Unit, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Eichinger, Sabine" sort="Eichinger, Sabine" uniqKey="Eichinger S" first="Sabine" last="Eichinger">Sabine Eichinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine I, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Becattini, Cecilia" sort="Becattini, Cecilia" uniqKey="Becattini C" first="Cecilia" last="Becattini">Cecilia Becattini</name><affiliation wicri:level="1"><nlm:affiliation>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Agnelli, Giancarlo" sort="Agnelli, Giancarlo" uniqKey="Agnelli G" first="Giancarlo" last="Agnelli">Giancarlo Agnelli</name><affiliation wicri:level="1"><nlm:affiliation>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Buller, Harry R" sort="Buller, Harry R" uniqKey="Buller H" first="Harry R" last="Büller">Harry R. Büller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Brighton, Timothy A" sort="Brighton, Timothy A" uniqKey="Brighton T" first="Timothy A" last="Brighton">Timothy A. 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wicri:step="PubMed">000581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis.</title><author><name sortKey="Khan, Faizan" sort="Khan, Faizan" uniqKey="Khan F" first="Faizan" last="Khan">Faizan Khan</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Alvi" sort="Rahman, Alvi" uniqKey="Rahman A" first="Alvi" last="Rahman">Alvi Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Carrier, Marc" sort="Carrier, Marc" uniqKey="Carrier M" first="Marc" last="Carrier">Marc Carrier</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Kearon, Clive" sort="Kearon, Clive" uniqKey="Kearon C" first="Clive" last="Kearon">Clive Kearon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Schulman, Sam" sort="Schulman, Sam" uniqKey="Schulman S" first="Sam" last="Schulman">Sam Schulman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Couturaud, Francis" sort="Couturaud, Francis" uniqKey="Couturaud F" first="Francis" last="Couturaud">Francis Couturaud</name><affiliation wicri:level="3"><nlm:affiliation>Departmentof Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departmentof Internal Medicine and Chest Diseases, Brest University Hospital, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Prandoni, Paolo" sort="Prandoni, Paolo" uniqKey="Prandoni P" first="Paolo" last="Prandoni">Paolo Prandoni</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, Vascular Medicine Unit, University of Padua, Padua, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cardiovascular Sciences, Vascular Medicine Unit, University of Padua, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Eichinger, Sabine" sort="Eichinger, Sabine" uniqKey="Eichinger S" first="Sabine" last="Eichinger">Sabine Eichinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medicine I, Medical University of Vienna, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Becattini, Cecilia" sort="Becattini, Cecilia" uniqKey="Becattini C" first="Cecilia" last="Becattini">Cecilia Becattini</name><affiliation wicri:level="1"><nlm:affiliation>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Agnelli, Giancarlo" sort="Agnelli, Giancarlo" uniqKey="Agnelli G" first="Giancarlo" last="Agnelli">Giancarlo Agnelli</name><affiliation wicri:level="1"><nlm:affiliation>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Buller, Harry R" sort="Buller, Harry R" uniqKey="Buller H" first="Harry R" last="Büller">Harry R. Büller</name><affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Brighton, Timothy A" sort="Brighton, Timothy A" uniqKey="Brighton T" first="Timothy A" last="Brighton">Timothy A. Brighton</name><affiliation wicri:level="3"><nlm:affiliation>Department of Haematology, Prince of Wales Hospital, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology, Prince of Wales Hospital, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Palareti, Gualtiero" sort="Palareti, Gualtiero" uniqKey="Palareti G" first="Gualtiero" last="Palareti">Gualtiero Palareti</name><affiliation wicri:level="1"><nlm:affiliation>University of Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Pinede, Laurent" sort="Pinede, Laurent" uniqKey="Pinede L" first="Laurent" last="Pinede">Laurent Pinede</name><affiliation wicri:level="3"><nlm:affiliation>Department of Internal Medicine, Infirmerie Protestante, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Internal Medicine, Infirmerie Protestante, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Sabri, Elham" sort="Sabri, Elham" uniqKey="Sabri E" first="Elham" last="Sabri">Elham Sabri</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Hutton, Brian" sort="Hutton, Brian" uniqKey="Hutton B" first="Brian" last="Hutton">Brian Hutton</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Wells, George A" sort="Wells, George A" uniqKey="Wells G" first="George A" last="Wells">George A. Wells</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rodger, Marc A" sort="Rodger, Marc A" uniqKey="Rodger M" first="Marc A" last="Rodger">Marc A. Rodger</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, University of Ottawa, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For patients with a first unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is a crucial clinical dilemma which has yet to be resolved. The decision to stop anticoagulant therapy (AT) after the initial 3-6 months or to continue AT indefinitely, is primarily governed by the long-term risk of recurrence when treatment is discontinued. This risk however, is not well established, hindering decision making.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28939565</PMID><DateCreated><Year>2017</Year><Month>09</Month><Day>23</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>11</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>Sep</Month><Day>21</Day></PubDate></JournalIssue><Title>BMJ open</Title><ISOAbbreviation>BMJ Open</ISOAbbreviation></Journal><ArticleTitle>Long-term risk of recurrence after discontinuing anticoagulants for a first unprovoked venous thromboembolism: protocol for a systematic review and meta-analysis.</ArticleTitle><Pagination><MedlinePgn>16950</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2017-016950</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">For patients with a first unprovoked venous thromboembolism (VTE), the optimal duration of anticoagulation is a crucial clinical dilemma which has yet to be resolved. The decision to stop anticoagulant therapy (AT) after the initial 3-6 months or to continue AT indefinitely, is primarily governed by the long-term risk of recurrence when treatment is discontinued. This risk however, is not well established, hindering decision making.</AbstractText><AbstractText Label="METHODS AND ANALYSIS" NlmCategory="UNASSIGNED">We will conduct a systematic review and a meta-analysis of studies involving patients diagnosed with a first, symptomatic unprovoked VTE or VTE provoked by minor transient risk factors, who have completed at least 3 months of initial AT; and who were followed-up for standardised time intervals of 1, 2, 5, 10 and 20 years (±3 months) after stopping AT. We will search (from inception to January 2017) MEDLINE, Embase and the Cochrane library for randomised controlled trials and prospective observational studies. Two reviewers will conduct all screening and data collection independently. The primary outcome of the rate of recurrent VTE at the standardised time intervals will be calculated for each study from the total number of recurrent events and the corresponding number of patient-years of follow-up. We will use a random-effects model to pool study results and report a weighted estimate of the absolute rate of recurrent VTE (events per 100 patient-years) over standardised time intervals of 1, 2, 5, 10 and 20 years after discontinuing anticoagulants.</AbstractText><AbstractText Label="ETHICS AND DISSEMINATION" NlmCategory="UNASSIGNED">Ethical approval is not applicable for this study. Findings from this study will be disseminated through peer-reviewed journal publication as well as relevant national and international conference presentations.</AbstractText><AbstractText Label="PROSPERO REGISTRATION NUMBER" NlmCategory="UNASSIGNED">CRD42017056309.</AbstractText><CopyrightInformation>© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khan</LastName><ForeName>Faizan</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>Alvi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrier</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ottawa Blood Disease Centre, The Ottawa Hospital, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kearon</LastName><ForeName>Clive</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulman</LastName><ForeName>Sam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Couturaud</LastName><ForeName>Francis</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Departmentof Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prandoni</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular Sciences, Vascular Medicine Unit, University of Padua, Padua, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eichinger</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine I, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becattini</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agnelli</LastName><ForeName>Giancarlo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Internal and Cardiovascular Medicine, Stroke Unit, University of Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Büller</LastName><ForeName>Harry R</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brighton</LastName><ForeName>Timothy A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Department of Haematology, Prince of Wales Hospital, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palareti</LastName><ForeName>Gualtiero</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>University of Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinede</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Infirmerie Protestante, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabri</LastName><ForeName>Elham</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutton</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wells</LastName><ForeName>George A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodger</LastName><ForeName>Marc A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ottawa Blood Disease Centre, The Ottawa Hospital, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>MARVELOUS Collaborators</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate 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):2402-2409</RefSource><PMID Version="1">27696701</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ. 2011 Oct 18;343:d5928</RefSource><PMID Version="1">22008217</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 2014 Mar 20;123(12):1794-801</RefSource><PMID Version="1">24497538</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Circulation. 2010 Apr 13;121(14):1630-6</RefSource><PMID Version="1">20351233</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Thromb Haemost. 2010 Oct;8(10):2313-5</RefSource><PMID Version="1">20738761</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2009 Jul 21;6(7):e1000097</RefSource><PMID Version="1">19621072</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">anticaogulants</Keyword><Keyword MajorTopicYN="N">recurrence</Keyword><Keyword MajorTopicYN="N">venous thrombosis</Keyword></KeywordList><CoiStatement>Competing interests: MC reports receiving research support form Leo Pharma and BMS, and honoraria from Pfizer, Bayer, BMS, and Sanofi, outside the submitted work. SS reports receiving honoraria from Boehringer Ingelheim, Bayer HealthCare, Daiichi Sankyo and Sanofi, and research support from Boehringer Ingelheim, Baxter and Octapharma, outside the submitted work. FC reports having received research grant support from Pfizer, honoraria for board memberships or symposia from Bayer and AstraZeneca, and travel support from Bayer, Daiichi Sankyo, Leo Pharma, Intermune, and Actelion, outside the submitted work. PP reports receiving consultancy and lectures fees from Bayer Pharma, Sanofi, Daiichi-Sankyo and Pfizer, outside the submitted work. CB reports receiving lectures fees from Bayer HealthCare, Bristol Meyer Squibb and Boehringer Ingelheim, outside the submitted work. GA reports personal fees from Bristol-Myers-Squibb, Pfizer, Bayer Healthcare, Boehringer Ingelheim, and Daiichi Sankyo, outside the submitted work. HRB reports receiving research support and consultancy fees from Sanofi-aventis, Bayer HealthCare, Bristol-Myers Squibb, Daiichi-Sankyo, GlaxoSmithKline, Pfizer, Roche, Isis, Thrombogenics, and Boehringer Ingelheim, outside the submitted work. TAB reports receiving personal fees from Bayer, Bayer Australia, Novo Nordisk, and Glaxo Smith Klein, outside the submitted work. GP reports Advisory Board for Alfa-Wassermann, Daiichi-Sankyo, Pfizer and Roche, and speaker fees from Werfen, outside the submitted work. BH reports receiving honoraria from Cornerstone Research Group for provision of methodologic advice related to systematic reviews and meta-analysis. MAR reports receiving research support from Biomerieux, outside of the submitted work. All other authors (FK, AR, CK, SE, LP, ES and GAW) declare that they have no relevant competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28939565</ArticleId><ArticleId IdType="pii">bmjopen-2017-016950</ArticleId><ArticleId IdType="doi">10.1136/bmjopen-2017-016950</ArticleId><ArticleId IdType="pmc">PMC5623531</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Canada</li><li>France</li><li>Italie</li><li>Pays-Bas</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Hollande-Septentrionale</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Rhône-Alpes</li><li>Région Bretagne</li><li>Vienne (Autriche)</li></region><settlement><li>Amsterdam</li><li>Brest</li><li>Hamilton (Ontario)</li><li>Lyon</li><li>Sydney</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université McMaster</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Khan, Faizan" sort="Khan, Faizan" uniqKey="Khan F" first="Faizan" last="Khan">Faizan Khan</name></noRegion><name sortKey="Carrier, Marc" sort="Carrier, Marc" uniqKey="Carrier M" first="Marc" last="Carrier">Marc Carrier</name><name sortKey="Hutton, Brian" sort="Hutton, Brian" uniqKey="Hutton B" first="Brian" last="Hutton">Brian Hutton</name><name sortKey="Kearon, Clive" sort="Kearon, Clive" uniqKey="Kearon C" first="Clive" last="Kearon">Clive Kearon</name><name sortKey="Rahman, Alvi" sort="Rahman, Alvi" uniqKey="Rahman A" first="Alvi" last="Rahman">Alvi Rahman</name><name sortKey="Rodger, Marc A" sort="Rodger, Marc A" uniqKey="Rodger M" first="Marc A" last="Rodger">Marc A. Rodger</name><name sortKey="Sabri, Elham" sort="Sabri, Elham" uniqKey="Sabri E" first="Elham" last="Sabri">Elham Sabri</name><name sortKey="Schulman, Sam" sort="Schulman, Sam" uniqKey="Schulman S" first="Sam" last="Schulman">Sam Schulman</name><name sortKey="Wells, George A" sort="Wells, George A" uniqKey="Wells G" first="George A" last="Wells">George A. Wells</name></country><country name="France"><region name="Région Bretagne"><name sortKey="Couturaud, Francis" sort="Couturaud, Francis" uniqKey="Couturaud F" first="Francis" last="Couturaud">Francis Couturaud</name></region><name sortKey="Pinede, Laurent" sort="Pinede, Laurent" uniqKey="Pinede L" first="Laurent" last="Pinede">Laurent Pinede</name></country><country name="Italie"><noRegion><name sortKey="Prandoni, Paolo" sort="Prandoni, Paolo" uniqKey="Prandoni P" first="Paolo" last="Prandoni">Paolo Prandoni</name></noRegion><name sortKey="Agnelli, Giancarlo" sort="Agnelli, Giancarlo" uniqKey="Agnelli G" first="Giancarlo" last="Agnelli">Giancarlo Agnelli</name><name sortKey="Becattini, Cecilia" sort="Becattini, Cecilia" uniqKey="Becattini C" first="Cecilia" last="Becattini">Cecilia Becattini</name><name sortKey="Palareti, Gualtiero" sort="Palareti, Gualtiero" uniqKey="Palareti G" first="Gualtiero" last="Palareti">Gualtiero Palareti</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Eichinger, Sabine" sort="Eichinger, Sabine" uniqKey="Eichinger S" first="Sabine" last="Eichinger">Sabine Eichinger</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Buller, Harry R" sort="Buller, Harry R" uniqKey="Buller H" first="Harry R" last="Büller">Harry R. Büller</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Brighton, Timothy A" sort="Brighton, Timothy A" uniqKey="Brighton T" first="Timothy A" last="Brighton">Timothy A. Brighton</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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