AustralieFrV1, Ncbi, Merge, bibRecord, 004574

Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL

Identifieur interne : 004574 ( Ncbi/Merge ); précédent : 004573; suivant : 004575

Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL

Auteurs : Paul M. Barr [États-Unis] ; Jennifer R. Brown [États-Unis] ; Peter Hillmen [Royaume-Uni] ; Susan O'Brien [États-Unis] ; Jacqueline C. Barrientos [États-Unis] ; Nishitha M. Reddy [États-Unis] ; Steven Coutre [États-Unis] ; Stephen P. Mulligan [Australie] ; Ulrich Jaeger [Autriche] ; Richard R. Furman [États-Unis] ; Florence Cymbalista [France] ; Marco Montillo [Italie] ; Claire Dearden [Royaume-Uni] ; Tadeusz Robak [Pologne] ; Carol Moreno [Espagne] ; John M. Pagel [États-Unis] ; Jan A. Burger [États-Unis] ; Samuel Suzuki [États-Unis] ; Juthamas Sukbuntherng [États-Unis] ; George Cole [États-Unis] ; Danelle F. James [États-Unis] ; John C. Byrd [États-Unis]

Source :

Blood [ 0006-4971 ] ; 2017.

RBID : PMC:5437732

Descripteurs français

KwdFr :
- Antinéoplasiques (administration et posologie), Antinéoplasiques (usage thérapeutique), Femelle, Humains, Inhibiteurs de protéines kinases (administration et posologie), Inhibiteurs de protéines kinases (usage thérapeutique), Leucémie chronique lymphocytaire à cellules B (génétique), Leucémie chronique lymphocytaire à cellules B (traitement médicamenteux), Mutation, Mâle, Observance thérapeutique, Protein-tyrosine kinases (antagonistes et inhibiteurs), Protéine p53 suppresseur de tumeur (génétique), Pyrazoles (administration et posologie), Pyrazoles (usage thérapeutique), Pyrimidines (administration et posologie), Pyrimidines (usage thérapeutique), Relation dose-effet des médicaments, Survie sans rechute.
MESH :
- administration et posologie : Antinéoplasiques, Inhibiteurs de protéines kinases, Pyrazoles, Pyrimidines.
- antagonistes et inhibiteurs : Protein-tyrosine kinases.
- génétique : Leucémie chronique lymphocytaire à cellules B, Protéine p53 suppresseur de tumeur.
- traitement médicamenteux : Leucémie chronique lymphocytaire à cellules B.
- usage thérapeutique : Antinéoplasiques, Inhibiteurs de protéines kinases, Pyrazoles, Pyrimidines.
- Femelle, Humains, Mutation, Mâle, Observance thérapeutique, Relation dose-effet des médicaments, Survie sans rechute.

English descriptors

KwdEn :
- Antineoplastic Agents (administration & dosage), Antineoplastic Agents (therapeutic use), Disease-Free Survival, Dose-Response Relationship, Drug, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy), Leukemia, Lymphocytic, Chronic, B-Cell (genetics), Male, Mutation, Patient Compliance, Protein Kinase Inhibitors (administration & dosage), Protein Kinase Inhibitors (therapeutic use), Protein-Tyrosine Kinases (antagonists & inhibitors), Pyrazoles (administration & dosage), Pyrazoles (therapeutic use), Pyrimidines (administration & dosage), Pyrimidines (therapeutic use), Tumor Suppressor Protein p53 (genetics).
MESH :
- chemical , administration & dosage : Antineoplastic Agents, Protein Kinase Inhibitors, Pyrazoles, Pyrimidines.
- chemical , antagonists & inhibitors : Protein-Tyrosine Kinases.
- chemical , genetics : Tumor Suppressor Protein p53.
- chemical , therapeutic use : Antineoplastic Agents, Protein Kinase Inhibitors, Pyrazoles, Pyrimidines.
- drug therapy : Leukemia, Lymphocytic, Chronic, B-Cell.
- genetics : Leukemia, Lymphocytic, Chronic, B-Cell.
- Disease-Free Survival, Dose-Response Relationship, Drug, Female, Humans, Male, Mutation, Patient Compliance.

Abstract

Key Points

Higher ibrutinib DI is associated with improved PFS, independent of del17p or TP53 mutation.

Ibrutinib hold for >1 week, often needed to manage adverse events, is associated with increased PFS events.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437732

DOI: 10.1182/blood-2016-12-737346
PubMed: 28373262
PubMed Central: 5437732

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: 001810
to stream Pmc, to step Curation: 001670
to stream Pmc, to step Checkpoint: 000253
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to stream PubMed, to step Curation: 000C26
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Links to Exploration step

PMC:5437732

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL</title>
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<author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:aff id="aff14">Department of Hematology, Medical University of Lodz, Lodz, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
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</author>
<author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name>
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<country xml:lang="fr">Espagne</country>
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</author>
<author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M." last="Pagel">John M. Pagel</name>
<affiliation wicri:level="2"><nlm:aff id="aff16">Swedish Cancer Institute, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
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<wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea>
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</author>
<author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A." last="Burger">Jan A. Burger</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
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<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
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<author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
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<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
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</author>
<author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F." last="James">Danelle F. James</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
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</author>
<author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C." last="Byrd">John C. Byrd</name>
<affiliation wicri:level="2"><nlm:aff id="aff18">The Ohio State University Medical Center, The Ohio State University, Columbus, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea>
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</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017">2017</date>
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<term>Disease-Free Survival</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy)</term>
<term>Leukemia, Lymphocytic, Chronic, B-Cell (genetics)</term>
<term>Male</term>
<term>Mutation</term>
<term>Patient Compliance</term>
<term>Protein Kinase Inhibitors (administration & dosage)</term>
<term>Protein Kinase Inhibitors (therapeutic use)</term>
<term>Protein-Tyrosine Kinases (antagonists & inhibitors)</term>
<term>Pyrazoles (administration & dosage)</term>
<term>Pyrazoles (therapeutic use)</term>
<term>Pyrimidines (administration & dosage)</term>
<term>Pyrimidines (therapeutic use)</term>
<term>Tumor Suppressor Protein p53 (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques (administration et posologie)</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Inhibiteurs de protéines kinases (administration et posologie)</term>
<term>Inhibiteurs de protéines kinases (usage thérapeutique)</term>
<term>Leucémie chronique lymphocytaire à cellules B (génétique)</term>
<term>Leucémie chronique lymphocytaire à cellules B (traitement médicamenteux)</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Observance thérapeutique</term>
<term>Protein-tyrosine kinases (antagonistes et inhibiteurs)</term>
<term>Protéine p53 suppresseur de tumeur (génétique)</term>
<term>Pyrazoles (administration et posologie)</term>
<term>Pyrazoles (usage thérapeutique)</term>
<term>Pyrimidines (administration et posologie)</term>
<term>Pyrimidines (usage thérapeutique)</term>
<term>Relation dose-effet des médicaments</term>
<term>Survie sans rechute</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
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<term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
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<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protein-tyrosine kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Leukemia, Lymphocytic, Chronic, B-Cell</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Leukemia, Lymphocytic, Chronic, B-Cell</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Leucémie chronique lymphocytaire à cellules B</term>
<term>Protéine p53 suppresseur de tumeur</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Leucémie chronique lymphocytaire à cellules B</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Disease-Free Survival</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mutation</term>
<term>Patient Compliance</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Observance thérapeutique</term>
<term>Relation dose-effet des médicaments</term>
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<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Higher ibrutinib DI is associated with improved PFS, independent of del17p or <italic>TP53</italic>
 mutation.</p>
</list-item>
<list-item><p>Ibrutinib hold for >1 week, often needed to manage adverse events, is associated with increased PFS events.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
<double pmid="28373262"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL</title>
<author><name sortKey="Barr, Paul M" sort="Barr, Paul M" uniqKey="Barr P" first="Paul M." last="Barr">Paul M. Barr</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Wilmot Cancer Institute, University of Rochester, Rochester, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Wilmot Cancer Institute, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brown, Jennifer R" sort="Brown, Jennifer R" uniqKey="Brown J" first="Jennifer R." last="Brown">Jennifer R. Brown</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C." last="Barrientos">Jacqueline C. Barrientos</name>
<affiliation wicri:level="2"><nlm:aff id="aff5">Hofstra Northwell School of Medicine, Hempstead, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Hofstra Northwell School of Medicine, Hempstead</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reddy, Nishitha M" sort="Reddy, Nishitha M" uniqKey="Reddy N" first="Nishitha M." last="Reddy">Nishitha M. Reddy</name>
<affiliation wicri:level="2"><nlm:aff id="aff6">Vanderbilt-Ingram Cancer Center, Nashville, TN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Coutre, Steven" sort="Coutre, Steven" uniqKey="Coutre S" first="Steven" last="Coutre">Steven Coutre</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Cancer Center, Stanford University School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mulligan, Stephen P" sort="Mulligan, Stephen P" uniqKey="Mulligan S" first="Stephen P." last="Mulligan">Stephen P. Mulligan</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Royal North Shore Hospital, Sydney, NSW, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name>
<affiliation wicri:level="3"><nlm:aff id="aff9">Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria;</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R." last="Furman">Richard R. Furman</name>
<affiliation wicri:level="2"><nlm:aff id="aff10">Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York Presbyterian Hospital, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name>
<affiliation wicri:level="3"><nlm:aff id="aff11">Hôpital Avicenne, Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Avicenne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name>
<affiliation wicri:level="3"><nlm:aff id="aff12">Niguarda Ca’ Granda Hospital, Milan, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Niguarda Ca’ Granda Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name>
<affiliation wicri:level="3"><nlm:aff id="aff13">Royal Marsden Hospital, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:aff id="aff14">Department of Hematology, Medical University of Lodz, Lodz, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de la Santa Creu Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M." last="Pagel">John M. Pagel</name>
<affiliation wicri:level="2"><nlm:aff id="aff16">Swedish Cancer Institute, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A." last="Burger">Jan A. Burger</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
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</affiliation>
</author>
<author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F." last="James">Danelle F. James</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C." last="Byrd">John C. Byrd</name>
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<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea>
</affiliation>
</author>
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<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28373262</idno>
<idno type="pmc">5437732</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437732</idno>
<idno type="RBID">PMC:5437732</idno>
<idno type="doi">10.1182/blood-2016-12-737346</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">001810</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL</title>
<author><name sortKey="Barr, Paul M" sort="Barr, Paul M" uniqKey="Barr P" first="Paul M." last="Barr">Paul M. Barr</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Wilmot Cancer Institute, University of Rochester, Rochester, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Wilmot Cancer Institute, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brown, Jennifer R" sort="Brown, Jennifer R" uniqKey="Brown J" first="Jennifer R." last="Brown">Jennifer R. Brown</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C." last="Barrientos">Jacqueline C. Barrientos</name>
<affiliation wicri:level="2"><nlm:aff id="aff5">Hofstra Northwell School of Medicine, Hempstead, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Hofstra Northwell School of Medicine, Hempstead</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reddy, Nishitha M" sort="Reddy, Nishitha M" uniqKey="Reddy N" first="Nishitha M." last="Reddy">Nishitha M. Reddy</name>
<affiliation wicri:level="2"><nlm:aff id="aff6">Vanderbilt-Ingram Cancer Center, Nashville, TN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Coutre, Steven" sort="Coutre, Steven" uniqKey="Coutre S" first="Steven" last="Coutre">Steven Coutre</name>
<affiliation wicri:level="2"><nlm:aff id="aff7">Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Cancer Center, Stanford University School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mulligan, Stephen P" sort="Mulligan, Stephen P" uniqKey="Mulligan S" first="Stephen P." last="Mulligan">Stephen P. Mulligan</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Royal North Shore Hospital, Sydney, NSW, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name>
<affiliation wicri:level="3"><nlm:aff id="aff9">Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria;</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R." last="Furman">Richard R. Furman</name>
<affiliation wicri:level="2"><nlm:aff id="aff10">Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York Presbyterian Hospital, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name>
<affiliation wicri:level="3"><nlm:aff id="aff11">Hôpital Avicenne, Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Avicenne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name>
<affiliation wicri:level="3"><nlm:aff id="aff12">Niguarda Ca’ Granda Hospital, Milan, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Niguarda Ca’ Granda Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name>
<affiliation wicri:level="3"><nlm:aff id="aff13">Royal Marsden Hospital, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:aff id="aff14">Department of Hematology, Medical University of Lodz, Lodz, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name>
<affiliation wicri:level="3"><nlm:aff id="aff15">Hospital de la Santa Creu Sant Pau, Barcelona, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de la Santa Creu Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M." last="Pagel">John M. Pagel</name>
<affiliation wicri:level="2"><nlm:aff id="aff16">Swedish Cancer Institute, Seattle, WA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A." last="Burger">Jan A. Burger</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F." last="James">Danelle F. James</name>
<affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C." last="Byrd">John C. Byrd</name>
<affiliation wicri:level="2"><nlm:aff id="aff18">The Ohio State University Medical Center, The Ohio State University, Columbus, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Key Points</title>
<p><list list-type="bullet"><list-item><p>Higher ibrutinib DI is associated with improved PFS, independent of del17p or <italic>TP53</italic>
 mutation.</p>
</list-item>
<list-item><p>Ibrutinib hold for >1 week, often needed to manage adverse events, is associated with increased PFS events.</p>
</list-item>
</list>
</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL.</title>
<author><name sortKey="Barr, Paul M" sort="Barr, Paul M" uniqKey="Barr P" first="Paul M" last="Barr">Paul M. Barr</name>
<affiliation wicri:level="2"><nlm:affiliation>Wilmot Cancer Institute, University of Rochester, Rochester, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Wilmot Cancer Institute, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brown, Jennifer R" sort="Brown, Jennifer R" uniqKey="Brown J" first="Jennifer R" last="Brown">Jennifer R. Brown</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name>
<affiliation wicri:level="1"><nlm:affiliation>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C" last="Barrientos">Jacqueline C. Barrientos</name>
<affiliation wicri:level="2"><nlm:affiliation>Hofstra Northwell School of Medicine, Hempstead, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Hofstra Northwell School of Medicine, Hempstead</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reddy, Nishitha M" sort="Reddy, Nishitha M" uniqKey="Reddy N" first="Nishitha M" last="Reddy">Nishitha M. Reddy</name>
<affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Coutre, Steven" sort="Coutre, Steven" uniqKey="Coutre S" first="Steven" last="Coutre">Steven Coutre</name>
<affiliation wicri:level="2"><nlm:affiliation>Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Cancer Center, Stanford University School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mulligan, Stephen P" sort="Mulligan, Stephen P" uniqKey="Mulligan S" first="Stephen P" last="Mulligan">Stephen P. Mulligan</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal North Shore Hospital, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R" last="Furman">Richard R. Furman</name>
<affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York Presbyterian Hospital, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Avicenne, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Avicenne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name>
<affiliation wicri:level="3"><nlm:affiliation>Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Niguarda Ca' Granda Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name>
<affiliation wicri:level="3"><nlm:affiliation>Royal Marsden Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Medical University of Lodz, Lodz, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital de la Santa Creu Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de la Santa Creu Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M" last="Pagel">John M. Pagel</name>
<affiliation wicri:level="2"><nlm:affiliation>Swedish Cancer Institute, Seattle, WA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A" last="Burger">Jan A. Burger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F" last="James">Danelle F. James</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C" last="Byrd">John C. Byrd</name>
<affiliation wicri:level="2"><nlm:affiliation>The Ohio State University Medical Center, The Ohio State University, Columbus, OH.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28373262</idno>
<idno type="pmid">28373262</idno>
<idno type="doi">10.1182/blood-2016-12-737346</idno>
<idno type="wicri:Area/PubMed/Corpus">000C29</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C29</idno>
<idno type="wicri:Area/PubMed/Curation">000C26</idno>
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<idno type="wicri:Area/PubMed/Checkpoint">000C26</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL.</title>
<author><name sortKey="Barr, Paul M" sort="Barr, Paul M" uniqKey="Barr P" first="Paul M" last="Barr">Paul M. Barr</name>
<affiliation wicri:level="2"><nlm:affiliation>Wilmot Cancer Institute, University of Rochester, Rochester, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Wilmot Cancer Institute, University of Rochester, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brown, Jennifer R" sort="Brown, Jennifer R" uniqKey="Brown J" first="Jennifer R" last="Brown">Jennifer R. Brown</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name>
<affiliation wicri:level="1"><nlm:affiliation>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C" last="Barrientos">Jacqueline C. Barrientos</name>
<affiliation wicri:level="2"><nlm:affiliation>Hofstra Northwell School of Medicine, Hempstead, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Hofstra Northwell School of Medicine, Hempstead</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reddy, Nishitha M" sort="Reddy, Nishitha M" uniqKey="Reddy N" first="Nishitha M" last="Reddy">Nishitha M. Reddy</name>
<affiliation wicri:level="2"><nlm:affiliation>Vanderbilt-Ingram Cancer Center, Nashville, TN.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Coutre, Steven" sort="Coutre, Steven" uniqKey="Coutre S" first="Steven" last="Coutre">Steven Coutre</name>
<affiliation wicri:level="2"><nlm:affiliation>Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford Cancer Center, Stanford University School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mulligan, Stephen P" sort="Mulligan, Stephen P" uniqKey="Mulligan S" first="Stephen P" last="Mulligan">Stephen P. Mulligan</name>
<affiliation wicri:level="1"><nlm:affiliation>Royal North Shore Hospital, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R" last="Furman">Richard R. Furman</name>
<affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York Presbyterian Hospital, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Avicenne, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Avicenne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name>
<affiliation wicri:level="3"><nlm:affiliation>Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Niguarda Ca' Granda Hospital, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name>
<affiliation wicri:level="3"><nlm:affiliation>Royal Marsden Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Hematology, Medical University of Lodz, Lodz, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospital de la Santa Creu Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de la Santa Creu Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M" last="Pagel">John M. Pagel</name>
<affiliation wicri:level="2"><nlm:affiliation>Swedish Cancer Institute, Seattle, WA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A" last="Burger">Jan A. Burger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F" last="James">Danelle F. James</name>
<affiliation wicri:level="2"><nlm:affiliation>Pharmacyclics LLC, AbbVie, Sunnyvale, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C" last="Byrd">John C. Byrd</name>
<affiliation wicri:level="2"><nlm:affiliation>The Ohio State University Medical Center, The Ohio State University, Columbus, OH.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (administration & dosage)</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Disease-Free Survival</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Leukemia, Lymphocytic, Chronic, B-Cell (drug therapy)</term>
<term>Leukemia, Lymphocytic, Chronic, B-Cell (genetics)</term>
<term>Male</term>
<term>Mutation</term>
<term>Patient Compliance</term>
<term>Protein Kinase Inhibitors (administration & dosage)</term>
<term>Protein Kinase Inhibitors (therapeutic use)</term>
<term>Protein-Tyrosine Kinases (antagonists & inhibitors)</term>
<term>Pyrazoles (administration & dosage)</term>
<term>Pyrazoles (therapeutic use)</term>
<term>Pyrimidines (administration & dosage)</term>
<term>Pyrimidines (therapeutic use)</term>
<term>Tumor Suppressor Protein p53 (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques (administration et posologie)</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Inhibiteurs de protéines kinases (administration et posologie)</term>
<term>Inhibiteurs de protéines kinases (usage thérapeutique)</term>
<term>Leucémie chronique lymphocytaire à cellules B (génétique)</term>
<term>Leucémie chronique lymphocytaire à cellules B (traitement médicamenteux)</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Observance thérapeutique</term>
<term>Protein-tyrosine kinases (antagonistes et inhibiteurs)</term>
<term>Protéine p53 suppresseur de tumeur (génétique)</term>
<term>Pyrazoles (administration et posologie)</term>
<term>Pyrazoles (usage thérapeutique)</term>
<term>Pyrimidines (administration et posologie)</term>
<term>Pyrimidines (usage thérapeutique)</term>
<term>Relation dose-effet des médicaments</term>
<term>Survie sans rechute</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Protein-Tyrosine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Tumor Suppressor Protein p53</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Protein Kinase Inhibitors</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protein-tyrosine kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Leukemia, Lymphocytic, Chronic, B-Cell</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Leukemia, Lymphocytic, Chronic, B-Cell</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Leucémie chronique lymphocytaire à cellules B</term>
<term>Protéine p53 suppresseur de tumeur</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Leucémie chronique lymphocytaire à cellules B</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Inhibiteurs de protéines kinases</term>
<term>Pyrazoles</term>
<term>Pyrimidines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Disease-Free Survival</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Mutation</term>
<term>Patient Compliance</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Humains</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Observance thérapeutique</term>
<term>Relation dose-effet des médicaments</term>
<term>Survie sans rechute</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Ibrutinib, an oral inhibitor of Bruton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that was maintained at 24 hours. It is unknown if intermittent interruption of ibrutinib therapy contributes to altered clinical outcomes. We therefore evaluated the effect of ibrutinib dose adherence on patient outcomes in the phase 3 RESONATE trial. The overall mean dose intensity (DI) was 95% with median treatment duration of ∼9 months. Pharmacokinetic assessment of ibrutinib exposure at 420-mg dose suggested similar exposure regardless of patient weight or age. As assessed by independent review committee, patients with higher DI experienced longer median progression-free survival (PFS) compared with those with lower DI regardless of del17p and/or TP53 status. Of 79 patients requiring a drug hold, treatment was restarted at the original dose in 73 (92%) patients. Mean duration of a missed-dose event was 18.7 days (range, 8-56). Patients missing ≥8 consecutive days of ibrutinib had a shorter median PFS vs those missing <8 days (10.9 months vs not reached). These results support sustained adherence to once-daily ibrutinib dosing at 420 mg as clinically feasible to achieve optimal outcomes in patients with previously treated CLL. The trial was registered at www.clinicaltrials.gov as #NCT01578707.</div>
</front>
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL

Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL

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