Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL
Identifieur interne : 000253 ( Pmc/Checkpoint ); précédent : 000252; suivant : 000254Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL
Auteurs : Paul M. Barr [États-Unis] ; Jennifer R. Brown [États-Unis] ; Peter Hillmen [Royaume-Uni] ; Susan O'Brien [États-Unis] ; Jacqueline C. Barrientos [États-Unis] ; Nishitha M. Reddy [États-Unis] ; Steven Coutre [États-Unis] ; Stephen P. Mulligan [Australie] ; Ulrich Jaeger [Autriche] ; Richard R. Furman [États-Unis] ; Florence Cymbalista [France] ; Marco Montillo [Italie] ; Claire Dearden [Royaume-Uni] ; Tadeusz Robak [Pologne] ; Carol Moreno [Espagne] ; John M. Pagel [États-Unis] ; Jan A. Burger [États-Unis] ; Samuel Suzuki [États-Unis] ; Juthamas Sukbuntherng [États-Unis] ; George Cole [États-Unis] ; Danelle F. James [États-Unis] ; John C. Byrd [États-Unis]Source :
- Blood [ 0006-4971 ] ; 2017.
Abstract
Higher ibrutinib DI is associated with improved PFS, independent of del17p or Ibrutinib hold for >1 week, often needed to manage adverse events, is associated with increased PFS events.
Url:
DOI: 10.1182/blood-2016-12-737346
PubMed: 28373262
PubMed Central: 5437732
Affiliations:
- Australie, Autriche, Espagne, France, Italie, Pologne, Royaume-Uni, États-Unis
- Angleterre, Californie, Catalogne, Grand Londres, Lombardie, Massachusetts, Ohio, Tennessee, Texas, Vienne (Autriche), Washington (État), État de New York, Île-de-France
- Barcelone, Londres, Milan, Paris, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:5437732Le document en format XML
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Brown</name><affiliation wicri:level="2"><nlm:aff id="aff2">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name><affiliation wicri:level="1"><nlm:aff id="aff3">The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C." last="Barrientos">Jacqueline C. 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Mulligan</name><affiliation wicri:level="1"><nlm:aff id="aff8">Royal North Shore Hospital, Sydney, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal North Shore Hospital, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name><affiliation wicri:level="3"><nlm:aff id="aff9">Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R." last="Furman">Richard R. Furman</name><affiliation wicri:level="2"><nlm:aff id="aff10">Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Weill Cornell Medical College, New York Presbyterian Hospital, New York</wicri:cityArea></affiliation></author><author><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name><affiliation wicri:level="3"><nlm:aff id="aff11">Hôpital Avicenne, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Avicenne, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name><affiliation wicri:level="3"><nlm:aff id="aff12">Niguarda Ca’ Granda Hospital, Milan, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Niguarda Ca’ Granda Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name><affiliation wicri:level="3"><nlm:aff id="aff13">Royal Marsden Hospital, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Hematology, Medical University of Lodz, Lodz, Poland;</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name><affiliation wicri:level="3"><nlm:aff id="aff15">Hospital de la Santa Creu Sant Pau, Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital de la Santa Creu Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M." last="Pagel">John M. Pagel</name><affiliation wicri:level="2"><nlm:aff id="aff16">Swedish Cancer Institute, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A." last="Burger">Jan A. Burger</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F." last="James">Danelle F. James</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C." last="Byrd">John C. Byrd</name><affiliation wicri:level="2"><nlm:aff id="aff18">The Ohio State University Medical Center, The Ohio State University, Columbus, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28373262</idno><idno type="pmc">5437732</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437732</idno><idno type="RBID">PMC:5437732</idno><idno type="doi">10.1182/blood-2016-12-737346</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001810</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001810</idno><idno type="wicri:Area/Pmc/Curation">001670</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001670</idno><idno type="wicri:Area/Pmc/Checkpoint">000253</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000253</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL</title><author><name sortKey="Barr, Paul M" sort="Barr, Paul M" uniqKey="Barr P" first="Paul M." last="Barr">Paul M. Barr</name><affiliation wicri:level="2"><nlm:aff id="aff1">Wilmot Cancer Institute, University of Rochester, Rochester, NY;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Wilmot Cancer Institute, University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Brown, Jennifer R" sort="Brown, Jennifer R" uniqKey="Brown J" first="Jennifer R." last="Brown">Jennifer R. Brown</name><affiliation wicri:level="2"><nlm:aff id="aff2">Dana-Farber Cancer Institute, Boston, MA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name><affiliation wicri:level="1"><nlm:aff id="aff3">The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C." last="Barrientos">Jacqueline C. Barrientos</name><affiliation wicri:level="2"><nlm:aff id="aff5">Hofstra Northwell School of Medicine, Hempstead, NY;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Hofstra Northwell School of Medicine, Hempstead</wicri:cityArea></affiliation></author><author><name sortKey="Reddy, Nishitha M" sort="Reddy, Nishitha M" uniqKey="Reddy N" first="Nishitha M." last="Reddy">Nishitha M. Reddy</name><affiliation wicri:level="2"><nlm:aff id="aff6">Vanderbilt-Ingram Cancer Center, Nashville, TN;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt-Ingram Cancer Center, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Coutre, Steven" sort="Coutre, Steven" uniqKey="Coutre S" first="Steven" last="Coutre">Steven Coutre</name><affiliation wicri:level="2"><nlm:aff id="aff7">Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford Cancer Center, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Mulligan, Stephen P" sort="Mulligan, Stephen P" uniqKey="Mulligan S" first="Stephen P." last="Mulligan">Stephen P. Mulligan</name><affiliation wicri:level="1"><nlm:aff id="aff8">Royal North Shore Hospital, Sydney, NSW, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal North Shore Hospital, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name><affiliation wicri:level="3"><nlm:aff id="aff9">Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria;</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R." last="Furman">Richard R. Furman</name><affiliation wicri:level="2"><nlm:aff id="aff10">Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Weill Cornell Medical College, New York Presbyterian Hospital, New York</wicri:cityArea></affiliation></author><author><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name><affiliation wicri:level="3"><nlm:aff id="aff11">Hôpital Avicenne, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Avicenne, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name><affiliation wicri:level="3"><nlm:aff id="aff12">Niguarda Ca’ Granda Hospital, Milan, Italy;</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Niguarda Ca’ Granda Hospital, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name><affiliation wicri:level="3"><nlm:aff id="aff13">Royal Marsden Hospital, London, United Kingdom;</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Royal Marsden Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name><affiliation wicri:level="1"><nlm:aff id="aff14">Department of Hematology, Medical University of Lodz, Lodz, Poland;</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea><wicri:noRegion>Lodz</wicri:noRegion></affiliation></author><author><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name><affiliation wicri:level="3"><nlm:aff id="aff15">Hospital de la Santa Creu Sant Pau, Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital de la Santa Creu Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M." last="Pagel">John M. Pagel</name><affiliation wicri:level="2"><nlm:aff id="aff16">Swedish Cancer Institute, Seattle, WA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Swedish Cancer Institute, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A." last="Burger">Jan A. Burger</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F." last="James">Danelle F. James</name><affiliation wicri:level="2"><nlm:aff id="aff17">Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Pharmacyclics LLC, AbbVie, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C." last="Byrd">John C. Byrd</name><affiliation wicri:level="2"><nlm:aff id="aff18">The Ohio State University Medical Center, The Ohio State University, Columbus, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>The Ohio State University Medical Center, The Ohio State University, Columbus</wicri:cityArea></affiliation></author></analytic><series><title level="j">Blood</title><idno type="ISSN">0006-4971</idno><idno type="eISSN">1528-0020</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Higher ibrutinib DI is associated with improved PFS, independent of del17p or <italic>TP53</italic> mutation.</p></list-item><list-item><p>Ibrutinib hold for >1 week, often needed to manage adverse events, is associated with increased PFS events.</p></list-item></list></p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Blood</journal-id><journal-id journal-id-type="iso-abbrev">Blood</journal-id><journal-id journal-id-type="hwp">bloodjournal</journal-id><journal-id journal-id-type="pmc">blood</journal-id><journal-id journal-id-type="publisher-id">Blood</journal-id><journal-title-group><journal-title>Blood</journal-title></journal-title-group><issn pub-type="ppub">0006-4971</issn><issn pub-type="epub">1528-0020</issn><publisher><publisher-name>American Society of Hematology</publisher-name><publisher-loc>Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28373262</article-id><article-id pub-id-type="pmc">5437732</article-id><article-id pub-id-type="publisher-id">2016/737346</article-id><article-id pub-id-type="doi">10.1182/blood-2016-12-737346</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>29</subject><subject>8</subject><subject>39</subject></subj-group><subj-group subj-group-type="heading"><subject>Clinical Trials and Observations</subject></subj-group></article-categories><title-group><article-title>Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-9733-401X</contrib-id><name><surname>Barr</surname><given-names>Paul M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Jennifer R.</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hillmen</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>O'Brien</surname><given-names>Susan</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Barrientos</surname><given-names>Jacqueline C.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Reddy</surname><given-names>Nishitha M.</given-names></name><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Coutre</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Mulligan</surname><given-names>Stephen P.</given-names></name><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><name><surname>Jaeger</surname><given-names>Ulrich</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Furman</surname><given-names>Richard R.</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib contrib-type="author"><name><surname>Cymbalista</surname><given-names>Florence</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Montillo</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib contrib-type="author"><name><surname>Dearden</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib contrib-type="author"><name><surname>Robak</surname><given-names>Tadeusz</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib contrib-type="author"><name><surname>Moreno</surname><given-names>Carol</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib contrib-type="author"><name><surname>Pagel</surname><given-names>John M.</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib contrib-type="author"><name><surname>Burger</surname><given-names>Jan A.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Suzuki</surname><given-names>Samuel</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Sukbuntherng</surname><given-names>Juthamas</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Cole</surname><given-names>George</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>James</surname><given-names>Danelle F.</given-names></name><xref ref-type="aff" rid="aff17">17</xref></contrib><contrib contrib-type="author"><name><surname>Byrd</surname><given-names>John C.</given-names></name><xref ref-type="aff" rid="aff18">18</xref></contrib><aff id="aff1"><label>1</label>Wilmot Cancer Institute, University of Rochester, Rochester, NY;</aff><aff id="aff2"><label>2</label>Dana-Farber Cancer Institute, Boston, MA;</aff><aff id="aff3"><label>3</label>The Leeds Teaching Hospitals, St. James Institute of Oncology, Leeds, United Kingdom;</aff><aff id="aff4"><label>4</label>Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</aff><aff id="aff5"><label>5</label>Hofstra Northwell School of Medicine, Hempstead, NY;</aff><aff id="aff6"><label>6</label>Vanderbilt-Ingram Cancer Center, Nashville, TN;</aff><aff id="aff7"><label>7</label>Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA;</aff><aff id="aff8"><label>8</label>Royal North Shore Hospital, Sydney, NSW, Australia;</aff><aff id="aff9"><label>9</label>Division of Hematology, Department of Medicine I, Medical University of Vienna, Vienna, Austria;</aff><aff id="aff10"><label>10</label>Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY;</aff><aff id="aff11"><label>11</label>Hôpital Avicenne, Paris, France;</aff><aff id="aff12"><label>12</label>Niguarda Ca’ Granda Hospital, Milan, Italy;</aff><aff id="aff13"><label>13</label>Royal Marsden Hospital, London, United Kingdom;</aff><aff id="aff14"><label>14</label>Department of Hematology, Medical University of Lodz, Lodz, Poland;</aff><aff id="aff15"><label>15</label>Hospital de la Santa Creu Sant Pau, Barcelona, Spain;</aff><aff id="aff16"><label>16</label>Swedish Cancer Institute, Seattle, WA;</aff><aff id="aff17"><label>17</label>Pharmacyclics LLC, AbbVie, Sunnyvale, CA;</aff><aff id="aff18"><label>18</label>The Ohio State University Medical Center, The Ohio State University, Columbus, OH</aff></contrib-group><pub-date pub-type="ppub"><day>11</day><month>5</month><year>2017</year></pub-date><pub-date pub-type="epreprint"><day>03</day><month>4</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>5</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>129</volume><issue>19</issue><fpage>2612</fpage><lpage>2615</lpage><history><date date-type="received"><day>19</day><month>12</month><year>2016</year></date><date date-type="accepted"><day>20</day><month>3</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 by The American Society of Hematology</copyright-statement><copyright-year>2017</copyright-year></permissions><self-uri xlink:title="pdf" xlink:href="blood737346.pdf"></self-uri><abstract abstract-type="executive-summary"><title>Key Points</title><p><list list-type="bullet"><list-item><p>Higher ibrutinib DI is associated with improved PFS, independent of del17p or <italic>TP53</italic> mutation.</p></list-item><list-item><p>Ibrutinib hold for >1 week, often needed to manage adverse events, is associated with increased PFS events.</p></list-item></list></p></abstract><abstract><p>Ibrutinib, an oral inhibitor of Bruton’s tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) that was maintained at 24 hours. It is unknown if intermittent interruption of ibrutinib therapy contributes to altered clinical outcomes. We therefore evaluated the effect of ibrutinib dose adherence on patient outcomes in the phase 3 RESONATE trial. The overall mean dose intensity (DI) was 95% with median treatment duration of ∼9 months. Pharmacokinetic assessment of ibrutinib exposure at 420-mg dose suggested similar exposure regardless of patient weight or age. As assessed by independent review committee, patients with higher DI experienced longer median progression-free survival (PFS) compared with those with lower DI regardless of del17p and/or <italic>TP53</italic> status. Of 79 patients requiring a drug hold, treatment was restarted at the original dose in 73 (92%) patients. Mean duration of a missed-dose event was 18.7 days (range, 8-56). Patients missing ≥8 consecutive days of ibrutinib had a shorter median PFS vs those missing <8 days (10.9 months vs not reached). These results support sustained adherence to once-daily ibrutinib dosing at 420 mg as clinically feasible to achieve optimal outcomes in patients with previously treated CLL. The trial was registered at <ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</ext-link> as #NCT01578707.</p></abstract><counts><page-count count="4"></page-count></counts><custom-meta-group><custom-meta><meta-name>access</meta-name><meta-value>free</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Catalogne</li><li>Grand Londres</li><li>Lombardie</li><li>Massachusetts</li><li>Ohio</li><li>Tennessee</li><li>Texas</li><li>Vienne (Autriche)</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Londres</li><li>Milan</li><li>Paris</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Barr, Paul M" sort="Barr, Paul M" uniqKey="Barr P" first="Paul M." last="Barr">Paul M. Barr</name></region><name sortKey="Barrientos, Jacqueline C" sort="Barrientos, Jacqueline C" uniqKey="Barrientos J" first="Jacqueline C." last="Barrientos">Jacqueline C. Barrientos</name><name sortKey="Brown, Jennifer R" sort="Brown, Jennifer R" uniqKey="Brown J" first="Jennifer R." last="Brown">Jennifer R. Brown</name><name sortKey="Burger, Jan A" sort="Burger, Jan A" uniqKey="Burger J" first="Jan A." last="Burger">Jan A. Burger</name><name sortKey="Byrd, John C" sort="Byrd, John C" uniqKey="Byrd J" first="John C." last="Byrd">John C. Byrd</name><name sortKey="Cole, George" sort="Cole, George" uniqKey="Cole G" first="George" last="Cole">George Cole</name><name sortKey="Coutre, Steven" sort="Coutre, Steven" uniqKey="Coutre S" first="Steven" last="Coutre">Steven Coutre</name><name sortKey="Furman, Richard R" sort="Furman, Richard R" uniqKey="Furman R" first="Richard R." last="Furman">Richard R. Furman</name><name sortKey="James, Danelle F" sort="James, Danelle F" uniqKey="James D" first="Danelle F." last="James">Danelle F. James</name><name sortKey="O Brien, Susan" sort="O Brien, Susan" uniqKey="O Brien S" first="Susan" last="O'Brien">Susan O'Brien</name><name sortKey="Pagel, John M" sort="Pagel, John M" uniqKey="Pagel J" first="John M." last="Pagel">John M. Pagel</name><name sortKey="Reddy, Nishitha M" sort="Reddy, Nishitha M" uniqKey="Reddy N" first="Nishitha M." last="Reddy">Nishitha M. Reddy</name><name sortKey="Sukbuntherng, Juthamas" sort="Sukbuntherng, Juthamas" uniqKey="Sukbuntherng J" first="Juthamas" last="Sukbuntherng">Juthamas Sukbuntherng</name><name sortKey="Suzuki, Samuel" sort="Suzuki, Samuel" uniqKey="Suzuki S" first="Samuel" last="Suzuki">Samuel Suzuki</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Hillmen, Peter" sort="Hillmen, Peter" uniqKey="Hillmen P" first="Peter" last="Hillmen">Peter Hillmen</name></noRegion><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name></country><country name="Australie"><noRegion><name sortKey="Mulligan, Stephen P" sort="Mulligan, Stephen P" uniqKey="Mulligan S" first="Stephen P." last="Mulligan">Stephen P. Mulligan</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Jaeger, Ulrich" sort="Jaeger, Ulrich" uniqKey="Jaeger U" first="Ulrich" last="Jaeger">Ulrich Jaeger</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Cymbalista, Florence" sort="Cymbalista, Florence" uniqKey="Cymbalista F" first="Florence" last="Cymbalista">Florence Cymbalista</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="Montillo, Marco" sort="Montillo, Marco" uniqKey="Montillo M" first="Marco" last="Montillo">Marco Montillo</name></region></country><country name="Pologne"><noRegion><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Moreno, Carol" sort="Moreno, Carol" uniqKey="Moreno C" first="Carol" last="Moreno">Carol Moreno</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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