Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice
Identifieur interne : 003F43 ( Ncbi/Merge ); précédent : 003F42; suivant : 003F44Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice
Auteurs : Michelle Chonwerawong ; Patrick Avé [France] ; Michel Huerre [France] ; Richard L. FerreroSource :
- Gut Pathogens [ 1757-4749 ] ; 2016.
Abstract
Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic
At 7 months post-infection with
The work shows that in mice on a BALB/c background, IFN-γ is not required for bacterial clearance, antibody responses, nor gastric inflammation. Conversely, IFN-γ appears to play a role in the development of gastric lymphoid follicles, which are precursor lesions to mucosa-associated lymphoid tissue (MALT) lymphoma. This study highlights the importance of mouse host background on the susceptibility to
Url:
DOI: 10.1186/s13099-016-0142-0
PubMed: 27895717
PubMed Central: 5117576
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in <italic>Helicobacter</italic>
-infected BALB/c mice</title>
<author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name>
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<series><title level="j">Gut Pathogens</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic <italic>Helicobacter</italic>
infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in <italic>Helicobacter</italic>
-induced inflammation in BALB/c mice which have Th2-polarised immune responses.</p>
</sec>
<sec><title>Results</title>
<p>At 7 months post-infection with <italic>Helicobacter felis,</italic>
IFN-γ deficiency in BALB/c mice had no significant effect on <italic>H. felis</italic>
colonisation levels in the gastric mucosa, nor on humoral responses, or gastritis severity. <italic>Ifng</italic>
<sup>−/−</sup>
animals with chronic <italic>H. felis</italic>
infection did, however, develop significantly fewer lymphoid follicle lesions, as well as increased IL-4 splenocyte responses, when compared with infected <italic>Ifng</italic>
<sup>+/+</sup>
mice (P = 0.015 and P = 0.0004, respectively).</p>
</sec>
<sec><title>Conclusions</title>
<p>The work shows that in mice on a BALB/c background, IFN-γ is not required for bacterial clearance, antibody responses, nor gastric inflammation. Conversely, IFN-γ appears to play a role in the development of gastric lymphoid follicles, which are precursor lesions to mucosa-associated lymphoid tissue (MALT) lymphoma. This study highlights the importance of mouse host background on the susceptibility to <italic>Helicobacter</italic>
-induced pathologies.</p>
</sec>
</div>
</front>
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-infected BALB/c mice</title>
<author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name>
<affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff5">Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L." last="Ferrero">Richard L. Ferrero</name>
<affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff3">Department of Microbiology, Monash University, Clayton, VIC Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC Australia</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">27895717</idno>
<idno type="pmc">5117576</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117576</idno>
<idno type="RBID">PMC:5117576</idno>
<idno type="doi">10.1186/s13099-016-0142-0</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in <italic>Helicobacter</italic>
-infected BALB/c mice</title>
<author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name>
<affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff5">Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L." last="Ferrero">Richard L. Ferrero</name>
<affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff3">Department of Microbiology, Monash University, Clayton, VIC Australia</nlm:aff>
<wicri:noCountry code="subfield">VIC Australia</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Gut Pathogens</title>
<idno type="eISSN">1757-4749</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic <italic>Helicobacter</italic>
infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in <italic>Helicobacter</italic>
-induced inflammation in BALB/c mice which have Th2-polarised immune responses.</p>
</sec>
<sec><title>Results</title>
<p>At 7 months post-infection with <italic>Helicobacter felis,</italic>
IFN-γ deficiency in BALB/c mice had no significant effect on <italic>H. felis</italic>
colonisation levels in the gastric mucosa, nor on humoral responses, or gastritis severity. <italic>Ifng</italic>
<sup>−/−</sup>
animals with chronic <italic>H. felis</italic>
infection did, however, develop significantly fewer lymphoid follicle lesions, as well as increased IL-4 splenocyte responses, when compared with infected <italic>Ifng</italic>
<sup>+/+</sup>
mice (P = 0.015 and P = 0.0004, respectively).</p>
</sec>
<sec><title>Conclusions</title>
<p>The work shows that in mice on a BALB/c background, IFN-γ is not required for bacterial clearance, antibody responses, nor gastric inflammation. Conversely, IFN-γ appears to play a role in the development of gastric lymphoid follicles, which are precursor lesions to mucosa-associated lymphoid tissue (MALT) lymphoma. This study highlights the importance of mouse host background on the susceptibility to <italic>Helicobacter</italic>
-induced pathologies.</p>
</sec>
</div>
</front>
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<author><name sortKey="Stilgenbauer, S" uniqKey="Stilgenbauer S">S Stilgenbauer</name>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice.</title>
<author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name>
<affiliation><nlm:affiliation>Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia.</nlm:affiliation>
<wicri:noCountry code="subField">VIC 3123 Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Département de Pathologie, Institut Curie, 26 Rue d'Ulm, 75248 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Département de Pathologie, Institut Curie, 26 Rue d'Ulm, 75248 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L" last="Ferrero">Richard L. Ferrero</name>
<affiliation><nlm:affiliation>Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia ; Department of Microbiology, Monash University, Clayton, VIC Australia.</nlm:affiliation>
<wicri:noCountry code="subField">VIC Australia</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27895717</idno>
<idno type="pmid">27895717</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice.</title>
<author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name>
<affiliation><nlm:affiliation>Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia.</nlm:affiliation>
<wicri:noCountry code="subField">VIC 3123 Australia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name>
<affiliation wicri:level="3"><nlm:affiliation>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Département de Pathologie, Institut Curie, 26 Rue d'Ulm, 75248 Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Recherche et d'Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France ; Département de Pathologie, Institut Curie, 26 Rue d'Ulm, 75248 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L" last="Ferrero">Richard L. Ferrero</name>
<affiliation><nlm:affiliation>Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia ; Department of Microbiology, Monash University, Clayton, VIC Australia.</nlm:affiliation>
<wicri:noCountry code="subField">VIC Australia</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Gut pathogens</title>
<idno type="ISSN">1757-4749</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic Helicobacter infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in Helicobacter-induced inflammation in BALB/c mice which have Th2-polarised immune responses.</div>
</front>
</TEI>
</pubmed>
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