Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice
Identifieur interne : 000834 ( Pmc/Checkpoint ); précédent : 000833; suivant : 000835Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in Helicobacter-infected BALB/c mice
Auteurs : Michelle Chonwerawong ; Patrick Avé [France] ; Michel Huerre [France] ; Richard L. FerreroSource :
- Gut Pathogens [ 1757-4749 ] ; 2016.
Abstract
Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic
At 7 months post-infection with
The work shows that in mice on a BALB/c background, IFN-γ is not required for bacterial clearance, antibody responses, nor gastric inflammation. Conversely, IFN-γ appears to play a role in the development of gastric lymphoid follicles, which are precursor lesions to mucosa-associated lymphoid tissue (MALT) lymphoma. This study highlights the importance of mouse host background on the susceptibility to
Url:
DOI: 10.1186/s13099-016-0142-0
PubMed: 27895717
PubMed Central: 5117576
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in <italic>Helicobacter</italic>-infected BALB/c mice</title><author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name><affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff5">Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L." last="Ferrero">Richard L. Ferrero</name><affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Microbiology, Monash University, Clayton, VIC Australia</nlm:aff><wicri:noCountry code="subfield">VIC Australia</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27895717</idno><idno type="pmc">5117576</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117576</idno><idno type="RBID">PMC:5117576</idno><idno type="doi">10.1186/s13099-016-0142-0</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000D23</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D23</idno><idno type="wicri:Area/Pmc/Curation">000B84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B84</idno><idno type="wicri:Area/Pmc/Checkpoint">000834</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000834</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in <italic>Helicobacter</italic>-infected BALB/c mice</title><author><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name><affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff5">Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L." last="Ferrero">Richard L. Ferrero</name><affiliation><nlm:aff id="Aff1">Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</nlm:aff><wicri:noCountry code="subfield">VIC 3123 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3">Department of Microbiology, Monash University, Clayton, VIC Australia</nlm:aff><wicri:noCountry code="subfield">VIC Australia</wicri:noCountry></affiliation></author></analytic><series><title level="j">Gut Pathogens</title><idno type="eISSN">1757-4749</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic <italic>Helicobacter</italic> infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in <italic>Helicobacter</italic>-induced inflammation in BALB/c mice which have Th2-polarised immune responses.</p></sec><sec><title>Results</title><p>At 7 months post-infection with <italic>Helicobacter felis,</italic> IFN-γ deficiency in BALB/c mice had no significant effect on <italic>H. felis</italic> colonisation levels in the gastric mucosa, nor on humoral responses, or gastritis severity. <italic>Ifng</italic><sup>−/−</sup> animals with chronic <italic>H. felis</italic> infection did, however, develop significantly fewer lymphoid follicle lesions, as well as increased IL-4 splenocyte responses, when compared with infected <italic>Ifng</italic><sup>+/+</sup> mice (P = 0.015 and P = 0.0004, respectively).</p></sec><sec><title>Conclusions</title><p>The work shows that in mice on a BALB/c background, IFN-γ is not required for bacterial clearance, antibody responses, nor gastric inflammation. Conversely, IFN-γ appears to play a role in the development of gastric lymphoid follicles, which are precursor lesions to mucosa-associated lymphoid tissue (MALT) lymphoma. This study highlights the importance of mouse host background on the susceptibility to <italic>Helicobacter</italic>-induced pathologies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Correa, P" uniqKey="Correa P">P Correa</name></author><author><name sortKey="Houghton, J" uniqKey="Houghton J">J Houghton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karttunen, R" uniqKey="Karttunen R">R Karttunen</name></author><author><name sortKey="Karttunen, T" uniqKey="Karttunen T">T Karttunen</name></author><author><name sortKey="Ekre, Hp" uniqKey="Ekre H">HP Ekre</name></author><author><name sortKey="Macdonald, Tt" uniqKey="Macdonald T">TT MacDonald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammadi, M" uniqKey="Mohammadi M">M Mohammadi</name></author><author><name sortKey="Czinn, S" uniqKey="Czinn S">S Czinn</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Gut Pathog</journal-id><journal-id journal-id-type="iso-abbrev">Gut Pathog</journal-id><journal-title-group><journal-title>Gut Pathogens</journal-title></journal-title-group><issn pub-type="epub">1757-4749</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27895717</article-id><article-id pub-id-type="pmc">5117576</article-id><article-id pub-id-type="publisher-id">142</article-id><article-id pub-id-type="doi">10.1186/s13099-016-0142-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Interferon-γ promotes gastric lymphoid follicle formation but not gastritis in <italic>Helicobacter</italic>-infected BALB/c mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chonwerawong</surname><given-names>Michelle</given-names></name><address><email>Michelle.Chonwerawong@Hudson.org.au</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Avé</surname><given-names>Patrick</given-names></name><address><email>patrick.ave@pasteur.fr</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Huerre</surname><given-names>Michel</given-names></name><address><email>michel.huerre@curie.fr</email></address><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff5">5</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0001-6817-6211</contrib-id><name><surname>Ferrero</surname><given-names>Richard L.</given-names></name><address><phone>+61 03 8572 2728</phone><email>Richard.Ferrero@Hudson.org.au</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label>Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, VIC 3123 Australia</aff><aff id="Aff2"><label>2</label>Unité de Recherche et d’Expertise Histotechnologie et Pathologie, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</aff><aff id="Aff3"><label>3</label>Department of Microbiology, Monash University, Clayton, VIC Australia</aff><aff id="Aff4"><label>4</label>Unité de Histopathologie Humaine et Modèles Animaux, Institut Pasteur, 25-28 Rue du Dr Roux, 75724 Paris, France</aff><aff id="Aff5"><label>5</label>Département de Pathologie, Institut Curie, 26 Rue d’Ulm, 75248 Paris, France</aff></contrib-group><pub-date pub-type="epub"><day>21</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>21</day><month>11</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>8</volume><elocation-id>61</elocation-id><history><date date-type="received"><day>7</day><month>10</month><year>2016</year></date><date date-type="accepted"><day>14</day><month>11</month><year>2016</year></date></history><permissions><copyright-statement>© The Author(s) 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic <italic>Helicobacter</italic> infection. This finding is largely based on studies performed using mice that have polarised Th1 responses i.e. C57BL/6 animals. The current work aims to investigate the role of IFN-γ in <italic>Helicobacter</italic>-induced inflammation in BALB/c mice which have Th2-polarised immune responses.</p></sec><sec><title>Results</title><p>At 7 months post-infection with <italic>Helicobacter felis,</italic> IFN-γ deficiency in BALB/c mice had no significant effect on <italic>H. felis</italic> colonisation levels in the gastric mucosa, nor on humoral responses, or gastritis severity. <italic>Ifng</italic><sup>−/−</sup> animals with chronic <italic>H. felis</italic> infection did, however, develop significantly fewer lymphoid follicle lesions, as well as increased IL-4 splenocyte responses, when compared with infected <italic>Ifng</italic><sup>+/+</sup> mice (P = 0.015 and P = 0.0004, respectively).</p></sec><sec><title>Conclusions</title><p>The work shows that in mice on a BALB/c background, IFN-γ is not required for bacterial clearance, antibody responses, nor gastric inflammation. Conversely, IFN-γ appears to play a role in the development of gastric lymphoid follicles, which are precursor lesions to mucosa-associated lymphoid tissue (MALT) lymphoma. This study highlights the importance of mouse host background on the susceptibility to <italic>Helicobacter</italic>-induced pathologies.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd><italic>Helicobacter</italic></kwd><kwd>Interferon-gamma</kwd><kwd>Lymphoid follicle</kwd><kwd>Mucosa-associated lymphoid tissue</kwd><kwd>MALT lymphoma</kwd><kwd>BALB/c</kwd><kwd>T helper response</kwd><kwd>Gastric inflammation</kwd></kwd-group><funding-group><award-group><funding-source><institution>National health and Medical Research Council of Australia</institution></funding-source><award-id>APP1107930</award-id><award-id>APP1079904</award-id><principal-award-recipient><name><surname>Ferrero</surname><given-names>Richard L.</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution>Institut Pasteur</institution></funding-source><award-id>PTR38</award-id><principal-award-recipient><name><surname>Ferrero</surname><given-names>Richard L.</given-names></name></principal-award-recipient></award-group><award-group><funding-source><institution>Victorian Government’s Operational Infrastructure Support Program</institution></funding-source></award-group></funding-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Chonwerawong, Michelle" sort="Chonwerawong, Michelle" uniqKey="Chonwerawong M" first="Michelle" last="Chonwerawong">Michelle Chonwerawong</name><name sortKey="Ferrero, Richard L" sort="Ferrero, Richard L" uniqKey="Ferrero R" first="Richard L." last="Ferrero">Richard L. Ferrero</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name></region><name sortKey="Ave, Patrick" sort="Ave, Patrick" uniqKey="Ave P" first="Patrick" last="Avé">Patrick Avé</name><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name><name sortKey="Huerre, Michel" sort="Huerre, Michel" uniqKey="Huerre M" first="Michel" last="Huerre">Michel Huerre</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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