The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus
Identifieur interne : 003A28 ( Ncbi/Merge ); précédent : 003A27; suivant : 003A29The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus
Auteurs : Andrew Richard Armstrong [France, Australie] ; Susan Elizabeth Herrmann ; Olivier Chassany [France] ; Christophe Lalanne [France] ; Mariliza Henrique Da Silva [Brésil] ; Eliana Galano [Brésil] ; Patrizia M. Carrieri [France] ; Vincent Estellon [France] ; Philippe Sogni [France] ; Martin Duracinsky [France]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Australie, Brésil, Coopération internationale, Enquêtes et questionnaires (normes), Fatigue, Femelle, France, Hepacivirus (physiologie), Humains, Hépatite C (), Hépatite C (psychologie), Indicateurs d'état de santé, Mâle, Projets pilotes, Psychométrie (), Psychométrie (normes), Qualité de vie (psychologie).
- MESH :
- normes : Enquêtes et questionnaires, Psychométrie.
- physiologie : Hepacivirus.
- psychologie : Hépatite C, Qualité de vie.
- Adulte, Adulte d'âge moyen, Australie, Brésil, Coopération internationale, Fatigue, Femelle, France, Humains, Hépatite C, Indicateurs d'état de santé, Mâle, Projets pilotes, Psychométrie.
English descriptors
- KwdEn :
- Adult, Australia, Brazil, Fatigue, Female, France, Health Status Indicators, Hepacivirus (physiology), Hepatitis C (psychology), Hepatitis C (therapy), Humans, International Cooperation, Male, Middle Aged, Pilot Projects, Psychometrics (methods), Psychometrics (standards), Quality of Life (psychology), Surveys and Questionnaires (standards).
- MESH :
- methods : Psychometrics.
- physiology : Hepacivirus.
- psychology : Hepatitis C, Quality of Life.
- standards : Psychometrics, Surveys and Questionnaires.
- therapy : Hepatitis C.
- Adult, Australia, Brazil, Fatigue, Female, France, Health Status Indicators, Humans, International Cooperation, Male, Middle Aged, Pilot Projects.
Abstract
Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects which further impair HRQL. New treatments appear potent, effective and tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people with hepatitis C are largely non-specific and will be needed in the new treatment era. Therefore, we developed a conceptually valid multidimensional model of HCV-specific quality of life and pilot survey instrument, the Patient Reported Outcome Quality of Life survey for HCV (PROQOL-HCV).
HCV patients from France (
Fifteen content dimensions were derived from the qualitative analysis, refined and fitted to four domains: (1) Physical Health included: fatigue, pain, sleep, sexual impairment and physical activity; (2) Mental Health: psychological distress, psychosocial impact, and cognition; (3) Social Health: support, stigma, social activity, substance use; (4) Treatment: management, side effects, and fear of treatment failure. The impact of some dimensions extended beyond their primary domain including: physical activity, cognition, sleep, sexual impairment, and the three treatment dimensions. A bank of 300 items was constructed to reflect patient reports and, following expert review, reduced to a 72-item pilot questionnaire.
We present a conceptually valid multidimensional model of HCV-specific quality of life and the pilot survey instrument, PROQOL-HCV. The model is widely inclusive of the experience of hepatitis C and the first to include the treatment dimension.
Url:
DOI: 10.1186/s12879-016-1771-0
PubMed: 27553866
PubMed Central: 4994204
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Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Australian Institute of Family Studies, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute of Family Studies, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Herrmann, Susan Elizabeth" sort="Herrmann, Susan Elizabeth" uniqKey="Herrmann S" first="Susan Elizabeth" last="Herrmann">Susan Elizabeth Herrmann</name><affiliation><nlm:aff id="Aff3">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia Australia</nlm:aff><wicri:noCountry code="subfield">Western Australia Australia</wicri:noCountry></affiliation></author><author><name sortKey="Chassany, Olivier" sort="Chassany, Olivier" uniqKey="Chassany O" first="Olivier" last="Chassany">Olivier Chassany</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lalanne, Christophe" sort="Lalanne, Christophe" uniqKey="Lalanne C" first="Christophe" last="Lalanne">Christophe Lalanne</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Da Silva, Mariliza Henrique" sort="Da Silva, Mariliza Henrique" uniqKey="Da Silva M" first="Mariliza Henrique" last="Da Silva">Mariliza Henrique Da Silva</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Galano, Eliana" sort="Galano, Eliana" uniqKey="Galano E" first="Eliana" last="Galano">Eliana Galano</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Carrieri, Patrizia M" sort="Carrieri, Patrizia M" uniqKey="Carrieri P" first="Patrizia M." last="Carrieri">Patrizia M. Carrieri</name><affiliation wicri:level="3"><nlm:aff id="Aff6">U912 (SE4S), INSERM, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>U912 (SE4S), INSERM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Estellon, Vincent" sort="Estellon, Vincent" uniqKey="Estellon V" first="Vincent" last="Estellon">Vincent Estellon</name><affiliation wicri:level="4"><nlm:aff id="Aff7">Université Paris Descartes, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sogni, Philippe" sort="Sogni, Philippe" uniqKey="Sogni P" first="Philippe" last="Sogni">Philippe Sogni</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Service d’Hépatologie, Hopital Cochin, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Hépatologie, Hopital Cochin, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duracinsky, Martin" sort="Duracinsky, Martin" uniqKey="Duracinsky M" first="Martin" last="Duracinsky">Martin Duracinsky</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9">Service de Médecine Interne et d’Immunologie Clinique, Hopital Bicetre, AP-HP, Kremlin-Bicetre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne et d’Immunologie Clinique, Hopital Bicetre, AP-HP, Kremlin-Bicetre</wicri:regionArea><wicri:noRegion>Kremlin-Bicetre</wicri:noRegion><wicri:noRegion>Kremlin-Bicetre</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Australia</term><term>Brazil</term><term>Fatigue</term><term>Female</term><term>France</term><term>Health Status Indicators</term><term>Hepacivirus (physiology)</term><term>Hepatitis C (psychology)</term><term>Hepatitis C (therapy)</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Psychometrics (methods)</term><term>Psychometrics (standards)</term><term>Quality of Life (psychology)</term><term>Surveys and Questionnaires (standards)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Australie</term><term>Brésil</term><term>Coopération internationale</term><term>Enquêtes et questionnaires (normes)</term><term>Fatigue</term><term>Femelle</term><term>France</term><term>Hepacivirus (physiologie)</term><term>Humains</term><term>Hépatite C ()</term><term>Hépatite C (psychologie)</term><term>Indicateurs d'état de santé</term><term>Mâle</term><term>Projets pilotes</term><term>Psychométrie ()</term><term>Psychométrie (normes)</term><term>Qualité de vie (psychologie)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychometrics</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Enquêtes et questionnaires</term><term>Psychométrie</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Hépatite C</term><term>Qualité de vie</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Hepatitis C</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Psychometrics</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Australia</term><term>Brazil</term><term>Fatigue</term><term>Female</term><term>France</term><term>Health Status Indicators</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Australie</term><term>Brésil</term><term>Coopération internationale</term><term>Fatigue</term><term>Femelle</term><term>France</term><term>Humains</term><term>Hépatite C</term><term>Indicateurs d'état de santé</term><term>Mâle</term><term>Projets pilotes</term><term>Psychométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects which further impair HRQL. New treatments appear potent, effective and tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people with hepatitis C are largely non-specific and will be needed in the new treatment era. Therefore, we developed a conceptually valid multidimensional model of HCV-specific quality of life and pilot survey instrument, the Patient Reported Outcome Quality of Life survey for HCV (PROQOL-HCV).</p></sec><sec><title>Methods</title><p>HCV patients from France (<italic>n</italic> = 30), Brazil (<italic>n</italic> = 20) and Australia (<italic>n</italic> = 20) were interviewed to investigate HCV-HRQL issues raised in the scientific literature and by treatment specialists. Interviews were recorded, transcribed and translated into English and French.</p></sec><sec><title>Results</title><p>Fifteen content dimensions were derived from the qualitative analysis, refined and fitted to four domains: (1) Physical Health included: fatigue, pain, sleep, sexual impairment and physical activity; (2) Mental Health: psychological distress, psychosocial impact, and cognition; (3) Social Health: support, stigma, social activity, substance use; (4) Treatment: management, side effects, and fear of treatment failure. The impact of some dimensions extended beyond their primary domain including: physical activity, cognition, sleep, sexual impairment, and the three treatment dimensions. A bank of 300 items was constructed to reflect patient reports and, following expert review, reduced to a 72-item pilot questionnaire.</p></sec><sec><title>Conclusion</title><p>We present a conceptually valid multidimensional model of HCV-specific quality of life and the pilot survey instrument, PROQOL-HCV. The model is widely inclusive of the experience of hepatitis C and the first to include the treatment dimension.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thomas, Dl" uniqKey="Thomas D">DL Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dolan, K" uniqKey="Dolan K">K Dolan</name></author><author><name sortKey="Teutsch, S" uniqKey="Teutsch S">S Teutsch</name></author><author><name sortKey="Scheuer, N" uniqKey="Scheuer N">N Scheuer</name></author><author><name sortKey="Levy, M" uniqKey="Levy M">M Levy</name></author><author><name sortKey="Rawlinson, W" uniqKey="Rawlinson W">W Rawlinson</name></author><author><name sortKey="Kaldor, J" uniqKey="Kaldor J">J Kaldor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rauch, A" uniqKey="Rauch A">A Rauch</name></author><author><name sortKey="Rickenbach, M" uniqKey="Rickenbach M">M Rickenbach</name></author><author><name sortKey="Weber, R" uniqKey="Weber R">R Weber</name></author><author><name sortKey="Hirschel, B" uniqKey="Hirschel B">B Hirschel</name></author><author><name sortKey="Tarr, Pe" uniqKey="Tarr P">PE Tarr</name></author><author><name sortKey="Bucher, Hc" uniqKey="Bucher H">HC Bucher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Henry, L" uniqKey="Henry L">L Henry</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dore, Gj" uniqKey="Dore G">GJ Dore</name></author><author><name sortKey="Lawitz, E" uniqKey="Lawitz E">E Lawitz</name></author><author><name sortKey="Hezode, C" uniqKey="Hezode C">C Hezode</name></author><author><name sortKey="Shafran, Sd" uniqKey="Shafran S">SD Shafran</name></author><author><name sortKey="Ramji, A" uniqKey="Ramji A">A Ramji</name></author><author><name sortKey="Tatum, Ha" uniqKey="Tatum H">HA Tatum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Dl" uniqKey="Thomas D">DL Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dore, Gj" uniqKey="Dore G">GJ Dore</name></author><author><name sortKey="Ward, J" uniqKey="Ward J">J Ward</name></author><author><name sortKey="Thursz, M" uniqKey="Thursz M">M Thursz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith Palmer, J" uniqKey="Smith Palmer J">J Smith-Palmer</name></author><author><name sortKey="Cerri, K" uniqKey="Cerri K">K Cerri</name></author><author><name sortKey="Valentine, W" uniqKey="Valentine W">W Valentine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kleinman, L" uniqKey="Kleinman L">L Kleinman</name></author><author><name sortKey="Mannix, S" uniqKey="Mannix S">S Mannix</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Kummer, S" uniqKey="Kummer S">S Kummer</name></author><author><name sortKey="L Talien, G" uniqKey="L Talien G">G L’Italien</name></author><author><name sortKey="Revicki, D" uniqKey="Revicki D">D Revicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danoff, A" uniqKey="Danoff A">A Danoff</name></author><author><name sortKey="Khan, O" uniqKey="Khan O">O Khan</name></author><author><name sortKey="Wan, Dw" uniqKey="Wan D">DW Wan</name></author><author><name sortKey="Hurst, L" uniqKey="Hurst L">L Hurst</name></author><author><name sortKey="Cohen, D" uniqKey="Cohen D">D Cohen</name></author><author><name sortKey="Tenner, Ct" uniqKey="Tenner C">CT Tenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Ga" uniqKey="Moore G">GA Moore</name></author><author><name sortKey="Hawley, Da" uniqKey="Hawley D">DA Hawley</name></author><author><name sortKey="Bradley, P" uniqKey="Bradley P">P Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillis, J" uniqKey="Gillis J">J Gillis</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Rourke, S" uniqKey="Rourke S">S Rourke</name></author><author><name sortKey="Rueda, S" uniqKey="Rueda S">S Rueda</name></author><author><name sortKey="O Rien, K" uniqKey="O Rien K">K O’Brien</name></author><author><name sortKey="Collins, E" uniqKey="Collins E">E Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinder, M" uniqKey="Kinder M">M Kinder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janke, Ea" uniqKey="Janke E">EA Janke</name></author><author><name sortKey="Mcgraw, S" uniqKey="Mcgraw S">S McGraw</name></author><author><name sortKey="Garcia Tsao, G" uniqKey="Garcia Tsao G">G Garcia-Tsao</name></author><author><name sortKey="Fraenkel, L" uniqKey="Fraenkel L">L Fraenkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Kallman, J" uniqKey="Kallman J">J Kallman</name></author><author><name sortKey="Kincaid, J" uniqKey="Kincaid J">J Kincaid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Rt" uniqKey="Anderson R">RT Anderson</name></author><author><name sortKey="Baran, Rw" uniqKey="Baran R">RW Baran</name></author><author><name sortKey="Dietz, B" uniqKey="Dietz B">B Dietz</name></author><author><name sortKey="Kallwitz, E" uniqKey="Kallwitz E">E Kallwitz</name></author><author><name sortKey="Erickson, P" uniqKey="Erickson P">P Erickson</name></author><author><name sortKey="Revicki, Da" uniqKey="Revicki D">DA Revicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Rt" uniqKey="Anderson R">RT Anderson</name></author><author><name sortKey="Baran, Rw" uniqKey="Baran R">RW Baran</name></author><author><name sortKey="Erickson, P" uniqKey="Erickson P">P Erickson</name></author><author><name sortKey="Revicki, Da" uniqKey="Revicki D">DA Revicki</name></author><author><name sortKey="Dietz, B" uniqKey="Dietz B">B Dietz</name></author><author><name sortKey="Gooch, K" uniqKey="Gooch K">K Gooch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bayliss, Ms" uniqKey="Bayliss M">MS Bayliss</name></author><author><name sortKey="Gandek, B" uniqKey="Gandek B">B Gandek</name></author><author><name sortKey="Bungay, Km" uniqKey="Bungay K">KM Bungay</name></author><author><name sortKey="Sugano, D" uniqKey="Sugano D">D Sugano</name></author><author><name sortKey="Hsu, Ma" uniqKey="Hsu M">MA Hsu</name></author><author><name sortKey="Ware, Je" uniqKey="Ware J">JE Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Zm" uniqKey="Younossi Z">ZM Younossi</name></author><author><name sortKey="Guyatt, G" uniqKey="Guyatt G">G Guyatt</name></author><author><name sortKey="Kiwi, M" uniqKey="Kiwi M">M Kiwi</name></author><author><name sortKey="Boparai, N" uniqKey="Boparai N">N Boparai</name></author><author><name sortKey="King, D" uniqKey="King D">D King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralnek, Im" uniqKey="Gralnek I">IM Gralnek</name></author><author><name sortKey="Hays, Rd" uniqKey="Hays R">RD Hays</name></author><author><name sortKey="Kilbourne, A" uniqKey="Kilbourne A">A Kilbourne</name></author><author><name sortKey="Rosen, Hr" uniqKey="Rosen H">HR Rosen</name></author><author><name sortKey="Keeffe, Eb" uniqKey="Keeffe E">EB Keeffe</name></author><author><name sortKey="Artinian, L" uniqKey="Artinian L">L Artinian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Plas, Sm" uniqKey="Van Der Plas S">SM van der Plas</name></author><author><name sortKey="Hansen, Be" uniqKey="Hansen B">BE Hansen</name></author><author><name sortKey="Boer, Jbd" uniqKey="Boer J">JBD Boer</name></author><author><name sortKey="Stijnen, T" uniqKey="Stijnen T">T Stijnen</name></author><author><name sortKey="Passchier, J" uniqKey="Passchier J">J Passchier</name></author><author><name sortKey="Man, Rad" uniqKey="Man R">RAD Man</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Glaser, B" uniqKey="Glaser B">B Glaser</name></author><author><name sortKey="Strauss, A" uniqKey="Strauss A">A Strauss</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lalanne, C" uniqKey="Lalanne C">C Lalanne</name></author><author><name sortKey="Chassany, O" uniqKey="Chassany O">O Chassany</name></author><author><name sortKey="Carrieri, P" uniqKey="Carrieri P">P Carrieri</name></author><author><name sortKey="Marcellin, F" uniqKey="Marcellin F">F Marcellin</name></author><author><name sortKey="Armstrong, Ar" uniqKey="Armstrong A">AR Armstrong</name></author><author><name sortKey="Lert, F" uniqKey="Lert F">F Lert</name></author><author><name sortKey="Spire, B" uniqKey="Spire B">B Spire</name></author><author><name sortKey="Dray Spira, R" uniqKey="Dray Spira R">R Dray-Spira</name></author><author><name sortKey="Duracinsky, M" uniqKey="Duracinsky M">M Duracinsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Henry, L" uniqKey="Henry L">L Henry</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="27553866"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus</title><author><name sortKey="Armstrong, Andrew Richard" sort="Armstrong, Andrew Richard" uniqKey="Armstrong A" first="Andrew Richard" last="Armstrong">Andrew Richard Armstrong</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Australian Institute of Family Studies, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute of Family Studies, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Herrmann, Susan Elizabeth" sort="Herrmann, Susan Elizabeth" uniqKey="Herrmann S" first="Susan Elizabeth" last="Herrmann">Susan Elizabeth Herrmann</name><affiliation><nlm:aff id="Aff3">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia Australia</nlm:aff><wicri:noCountry code="subfield">Western Australia Australia</wicri:noCountry></affiliation></author><author><name sortKey="Chassany, Olivier" sort="Chassany, Olivier" uniqKey="Chassany O" first="Olivier" last="Chassany">Olivier Chassany</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lalanne, Christophe" sort="Lalanne, Christophe" uniqKey="Lalanne C" first="Christophe" last="Lalanne">Christophe Lalanne</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Da Silva, Mariliza Henrique" sort="Da Silva, Mariliza Henrique" uniqKey="Da Silva M" first="Mariliza Henrique" last="Da Silva">Mariliza Henrique Da Silva</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Galano, Eliana" sort="Galano, Eliana" uniqKey="Galano E" first="Eliana" last="Galano">Eliana Galano</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Carrieri, Patrizia M" sort="Carrieri, Patrizia M" uniqKey="Carrieri P" first="Patrizia M." last="Carrieri">Patrizia M. Carrieri</name><affiliation wicri:level="3"><nlm:aff id="Aff6">U912 (SE4S), INSERM, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>U912 (SE4S), INSERM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Estellon, Vincent" sort="Estellon, Vincent" uniqKey="Estellon V" first="Vincent" last="Estellon">Vincent Estellon</name><affiliation wicri:level="4"><nlm:aff id="Aff7">Université Paris Descartes, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sogni, Philippe" sort="Sogni, Philippe" uniqKey="Sogni P" first="Philippe" last="Sogni">Philippe Sogni</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Service d’Hépatologie, Hopital Cochin, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Hépatologie, Hopital Cochin, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duracinsky, Martin" sort="Duracinsky, Martin" uniqKey="Duracinsky M" first="Martin" last="Duracinsky">Martin Duracinsky</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9">Service de Médecine Interne et d’Immunologie Clinique, Hopital Bicetre, AP-HP, Kremlin-Bicetre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne et d’Immunologie Clinique, Hopital Bicetre, AP-HP, Kremlin-Bicetre</wicri:regionArea><wicri:noRegion>Kremlin-Bicetre</wicri:noRegion><wicri:noRegion>Kremlin-Bicetre</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27553866</idno><idno type="pmc">4994204</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994204</idno><idno type="RBID">PMC:4994204</idno><idno type="doi">10.1186/s12879-016-1771-0</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000A98</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A98</idno><idno type="wicri:Area/Pmc/Curation">000A75</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A75</idno><idno type="wicri:Area/Pmc/Checkpoint">000558</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000558</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus</title><author><name sortKey="Armstrong, Andrew Richard" sort="Armstrong, Andrew Richard" uniqKey="Armstrong A" first="Andrew Richard" last="Armstrong">Andrew Richard Armstrong</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff2">Australian Institute of Family Studies, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Institute of Family Studies, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Herrmann, Susan Elizabeth" sort="Herrmann, Susan Elizabeth" uniqKey="Herrmann S" first="Susan Elizabeth" last="Herrmann">Susan Elizabeth Herrmann</name><affiliation><nlm:aff id="Aff3">Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia Australia</nlm:aff><wicri:noCountry code="subfield">Western Australia Australia</wicri:noCountry></affiliation></author><author><name sortKey="Chassany, Olivier" sort="Chassany, Olivier" uniqKey="Chassany O" first="Olivier" last="Chassany">Olivier Chassany</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lalanne, Christophe" sort="Lalanne, Christophe" uniqKey="Lalanne C" first="Christophe" last="Lalanne">Christophe Lalanne</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Da Silva, Mariliza Henrique" sort="Da Silva, Mariliza Henrique" uniqKey="Da Silva M" first="Mariliza Henrique" last="Da Silva">Mariliza Henrique Da Silva</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Galano, Eliana" sort="Galano, Eliana" uniqKey="Galano E" first="Eliana" last="Galano">Eliana Galano</name><affiliation wicri:level="3"><nlm:aff id="Aff5">Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Carrieri, Patrizia M" sort="Carrieri, Patrizia M" uniqKey="Carrieri P" first="Patrizia M." last="Carrieri">Patrizia M. Carrieri</name><affiliation wicri:level="3"><nlm:aff id="Aff6">U912 (SE4S), INSERM, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>U912 (SE4S), INSERM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Estellon, Vincent" sort="Estellon, Vincent" uniqKey="Estellon V" first="Vincent" last="Estellon">Vincent Estellon</name><affiliation wicri:level="4"><nlm:aff id="Aff7">Université Paris Descartes, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sogni, Philippe" sort="Sogni, Philippe" uniqKey="Sogni P" first="Philippe" last="Sogni">Philippe Sogni</name><affiliation wicri:level="3"><nlm:aff id="Aff8">Service d’Hépatologie, Hopital Cochin, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service d’Hépatologie, Hopital Cochin, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duracinsky, Martin" sort="Duracinsky, Martin" uniqKey="Duracinsky M" first="Martin" last="Duracinsky">Martin Duracinsky</name><affiliation wicri:level="3"><nlm:aff id="Aff1">EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff4">URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>URC-ECO, Hopital Hotel-Dieu, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9">Service de Médecine Interne et d’Immunologie Clinique, Hopital Bicetre, AP-HP, Kremlin-Bicetre, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Médecine Interne et d’Immunologie Clinique, Hopital Bicetre, AP-HP, Kremlin-Bicetre</wicri:regionArea><wicri:noRegion>Kremlin-Bicetre</wicri:noRegion><wicri:noRegion>Kremlin-Bicetre</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects which further impair HRQL. New treatments appear potent, effective and tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people with hepatitis C are largely non-specific and will be needed in the new treatment era. Therefore, we developed a conceptually valid multidimensional model of HCV-specific quality of life and pilot survey instrument, the Patient Reported Outcome Quality of Life survey for HCV (PROQOL-HCV).</p></sec><sec><title>Methods</title><p>HCV patients from France (<italic>n</italic> = 30), Brazil (<italic>n</italic> = 20) and Australia (<italic>n</italic> = 20) were interviewed to investigate HCV-HRQL issues raised in the scientific literature and by treatment specialists. Interviews were recorded, transcribed and translated into English and French.</p></sec><sec><title>Results</title><p>Fifteen content dimensions were derived from the qualitative analysis, refined and fitted to four domains: (1) Physical Health included: fatigue, pain, sleep, sexual impairment and physical activity; (2) Mental Health: psychological distress, psychosocial impact, and cognition; (3) Social Health: support, stigma, social activity, substance use; (4) Treatment: management, side effects, and fear of treatment failure. The impact of some dimensions extended beyond their primary domain including: physical activity, cognition, sleep, sexual impairment, and the three treatment dimensions. A bank of 300 items was constructed to reflect patient reports and, following expert review, reduced to a 72-item pilot questionnaire.</p></sec><sec><title>Conclusion</title><p>We present a conceptually valid multidimensional model of HCV-specific quality of life and the pilot survey instrument, PROQOL-HCV. The model is widely inclusive of the experience of hepatitis C and the first to include the treatment dimension.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thomas, Dl" uniqKey="Thomas D">DL Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dolan, K" uniqKey="Dolan K">K Dolan</name></author><author><name sortKey="Teutsch, S" uniqKey="Teutsch S">S Teutsch</name></author><author><name sortKey="Scheuer, N" uniqKey="Scheuer N">N Scheuer</name></author><author><name sortKey="Levy, M" uniqKey="Levy M">M Levy</name></author><author><name sortKey="Rawlinson, W" uniqKey="Rawlinson W">W Rawlinson</name></author><author><name sortKey="Kaldor, J" uniqKey="Kaldor J">J Kaldor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rauch, A" uniqKey="Rauch A">A Rauch</name></author><author><name sortKey="Rickenbach, M" uniqKey="Rickenbach M">M Rickenbach</name></author><author><name sortKey="Weber, R" uniqKey="Weber R">R Weber</name></author><author><name sortKey="Hirschel, B" uniqKey="Hirschel B">B Hirschel</name></author><author><name sortKey="Tarr, Pe" uniqKey="Tarr P">PE Tarr</name></author><author><name sortKey="Bucher, Hc" uniqKey="Bucher H">HC Bucher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Henry, L" uniqKey="Henry L">L Henry</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dore, Gj" uniqKey="Dore G">GJ Dore</name></author><author><name sortKey="Lawitz, E" uniqKey="Lawitz E">E Lawitz</name></author><author><name sortKey="Hezode, C" uniqKey="Hezode C">C Hezode</name></author><author><name sortKey="Shafran, Sd" uniqKey="Shafran S">SD Shafran</name></author><author><name sortKey="Ramji, A" uniqKey="Ramji A">A Ramji</name></author><author><name sortKey="Tatum, Ha" uniqKey="Tatum H">HA Tatum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Dl" uniqKey="Thomas D">DL Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dore, Gj" uniqKey="Dore G">GJ Dore</name></author><author><name sortKey="Ward, J" uniqKey="Ward J">J Ward</name></author><author><name sortKey="Thursz, M" uniqKey="Thursz M">M Thursz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith Palmer, J" uniqKey="Smith Palmer J">J Smith-Palmer</name></author><author><name sortKey="Cerri, K" uniqKey="Cerri K">K Cerri</name></author><author><name sortKey="Valentine, W" uniqKey="Valentine W">W Valentine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kleinman, L" uniqKey="Kleinman L">L Kleinman</name></author><author><name sortKey="Mannix, S" uniqKey="Mannix S">S Mannix</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Kummer, S" uniqKey="Kummer S">S Kummer</name></author><author><name sortKey="L Talien, G" uniqKey="L Talien G">G L’Italien</name></author><author><name sortKey="Revicki, D" uniqKey="Revicki D">D Revicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danoff, A" uniqKey="Danoff A">A Danoff</name></author><author><name sortKey="Khan, O" uniqKey="Khan O">O Khan</name></author><author><name sortKey="Wan, Dw" uniqKey="Wan D">DW Wan</name></author><author><name sortKey="Hurst, L" uniqKey="Hurst L">L Hurst</name></author><author><name sortKey="Cohen, D" uniqKey="Cohen D">D Cohen</name></author><author><name sortKey="Tenner, Ct" uniqKey="Tenner C">CT Tenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Ga" uniqKey="Moore G">GA Moore</name></author><author><name sortKey="Hawley, Da" uniqKey="Hawley D">DA Hawley</name></author><author><name sortKey="Bradley, P" uniqKey="Bradley P">P Bradley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gillis, J" uniqKey="Gillis J">J Gillis</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C Cooper</name></author><author><name sortKey="Rourke, S" uniqKey="Rourke S">S Rourke</name></author><author><name sortKey="Rueda, S" uniqKey="Rueda S">S Rueda</name></author><author><name sortKey="O Rien, K" uniqKey="O Rien K">K O’Brien</name></author><author><name sortKey="Collins, E" uniqKey="Collins E">E Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kinder, M" uniqKey="Kinder M">M Kinder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janke, Ea" uniqKey="Janke E">EA Janke</name></author><author><name sortKey="Mcgraw, S" uniqKey="Mcgraw S">S McGraw</name></author><author><name sortKey="Garcia Tsao, G" uniqKey="Garcia Tsao G">G Garcia-Tsao</name></author><author><name sortKey="Fraenkel, L" uniqKey="Fraenkel L">L Fraenkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Kallman, J" uniqKey="Kallman J">J Kallman</name></author><author><name sortKey="Kincaid, J" uniqKey="Kincaid J">J Kincaid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Rt" uniqKey="Anderson R">RT Anderson</name></author><author><name sortKey="Baran, Rw" uniqKey="Baran R">RW Baran</name></author><author><name sortKey="Dietz, B" uniqKey="Dietz B">B Dietz</name></author><author><name sortKey="Kallwitz, E" uniqKey="Kallwitz E">E Kallwitz</name></author><author><name sortKey="Erickson, P" uniqKey="Erickson P">P Erickson</name></author><author><name sortKey="Revicki, Da" uniqKey="Revicki D">DA Revicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Rt" uniqKey="Anderson R">RT Anderson</name></author><author><name sortKey="Baran, Rw" uniqKey="Baran R">RW Baran</name></author><author><name sortKey="Erickson, P" uniqKey="Erickson P">P Erickson</name></author><author><name sortKey="Revicki, Da" uniqKey="Revicki D">DA Revicki</name></author><author><name sortKey="Dietz, B" uniqKey="Dietz B">B Dietz</name></author><author><name sortKey="Gooch, K" uniqKey="Gooch K">K Gooch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bayliss, Ms" uniqKey="Bayliss M">MS Bayliss</name></author><author><name sortKey="Gandek, B" uniqKey="Gandek B">B Gandek</name></author><author><name sortKey="Bungay, Km" uniqKey="Bungay K">KM Bungay</name></author><author><name sortKey="Sugano, D" uniqKey="Sugano D">D Sugano</name></author><author><name sortKey="Hsu, Ma" uniqKey="Hsu M">MA Hsu</name></author><author><name sortKey="Ware, Je" uniqKey="Ware J">JE Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Zm" uniqKey="Younossi Z">ZM Younossi</name></author><author><name sortKey="Guyatt, G" uniqKey="Guyatt G">G Guyatt</name></author><author><name sortKey="Kiwi, M" uniqKey="Kiwi M">M Kiwi</name></author><author><name sortKey="Boparai, N" uniqKey="Boparai N">N Boparai</name></author><author><name sortKey="King, D" uniqKey="King D">D King</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralnek, Im" uniqKey="Gralnek I">IM Gralnek</name></author><author><name sortKey="Hays, Rd" uniqKey="Hays R">RD Hays</name></author><author><name sortKey="Kilbourne, A" uniqKey="Kilbourne A">A Kilbourne</name></author><author><name sortKey="Rosen, Hr" uniqKey="Rosen H">HR Rosen</name></author><author><name sortKey="Keeffe, Eb" uniqKey="Keeffe E">EB Keeffe</name></author><author><name sortKey="Artinian, L" uniqKey="Artinian L">L Artinian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Plas, Sm" uniqKey="Van Der Plas S">SM van der Plas</name></author><author><name sortKey="Hansen, Be" uniqKey="Hansen B">BE Hansen</name></author><author><name sortKey="Boer, Jbd" uniqKey="Boer J">JBD Boer</name></author><author><name sortKey="Stijnen, T" uniqKey="Stijnen T">T Stijnen</name></author><author><name sortKey="Passchier, J" uniqKey="Passchier J">J Passchier</name></author><author><name sortKey="Man, Rad" uniqKey="Man R">RAD Man</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Glaser, B" uniqKey="Glaser B">B Glaser</name></author><author><name sortKey="Strauss, A" uniqKey="Strauss A">A Strauss</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lalanne, C" uniqKey="Lalanne C">C Lalanne</name></author><author><name sortKey="Chassany, O" uniqKey="Chassany O">O Chassany</name></author><author><name sortKey="Carrieri, P" uniqKey="Carrieri P">P Carrieri</name></author><author><name sortKey="Marcellin, F" uniqKey="Marcellin F">F Marcellin</name></author><author><name sortKey="Armstrong, Ar" uniqKey="Armstrong A">AR Armstrong</name></author><author><name sortKey="Lert, F" uniqKey="Lert F">F Lert</name></author><author><name sortKey="Spire, B" uniqKey="Spire B">B Spire</name></author><author><name sortKey="Dray Spira, R" uniqKey="Dray Spira R">R Dray-Spira</name></author><author><name sortKey="Duracinsky, M" uniqKey="Duracinsky M">M Duracinsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z" uniqKey="Younossi Z">Z Younossi</name></author><author><name sortKey="Henry, L" uniqKey="Henry L">L Henry</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus.</title><author><name sortKey="Armstrong, Andrew Richard" sort="Armstrong, Andrew Richard" uniqKey="Armstrong A" first="Andrew Richard" last="Armstrong">Andrew Richard Armstrong</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France. Andrew74.psy@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Herrmann, Susan Elizabeth" sort="Herrmann, Susan Elizabeth" uniqKey="Herrmann S" first="Susan Elizabeth" last="Herrmann">Susan Elizabeth Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Chassany, Olivier" sort="Chassany, Olivier" uniqKey="Chassany O" first="Olivier" last="Chassany">Olivier Chassany</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lalanne, Christophe" sort="Lalanne, Christophe" uniqKey="Lalanne C" first="Christophe" last="Lalanne">Christophe Lalanne</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Da Silva, Mariliza Henrique" sort="Da Silva, Mariliza Henrique" uniqKey="Da Silva M" first="Mariliza Henrique" last="Da Silva">Mariliza Henrique Da Silva</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Galano, Eliana" sort="Galano, Eliana" uniqKey="Galano E" first="Eliana" last="Galano">Eliana Galano</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Carrieri, Patrizia M" sort="Carrieri, Patrizia M" uniqKey="Carrieri P" first="Patrizia M" last="Carrieri">Patrizia M. Carrieri</name><affiliation wicri:level="3"><nlm:affiliation>U912 (SE4S), INSERM, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>U912 (SE4S), INSERM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Estellon, Vincent" sort="Estellon, Vincent" uniqKey="Estellon V" first="Vincent" last="Estellon">Vincent Estellon</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sogni, Philippe" sort="Sogni, Philippe" uniqKey="Sogni P" first="Philippe" last="Sogni">Philippe Sogni</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hépatologie, Hopital Cochin, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépatologie, Hopital Cochin, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duracinsky, Martin" sort="Duracinsky, Martin" uniqKey="Duracinsky M" first="Martin" last="Duracinsky">Martin Duracinsky</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27553866</idno><idno type="pmid">27553866</idno><idno type="doi">10.1186/s12879-016-1771-0</idno><idno type="wicri:Area/PubMed/Corpus">001A15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A15</idno><idno type="wicri:Area/PubMed/Curation">001991</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001991</idno><idno type="wicri:Area/PubMed/Checkpoint">001991</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The International development of PROQOL-HCV: An instrument to assess the health-related quality of life of patients treated for Hepatitis C virus.</title><author><name sortKey="Armstrong, Andrew Richard" sort="Armstrong, Andrew Richard" uniqKey="Armstrong A" first="Andrew Richard" last="Armstrong">Andrew Richard Armstrong</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France. Andrew74.psy@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Herrmann, Susan Elizabeth" sort="Herrmann, Susan Elizabeth" uniqKey="Herrmann S" first="Susan Elizabeth" last="Herrmann">Susan Elizabeth Herrmann</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia</wicri:regionArea><wicri:noRegion>Western Australia</wicri:noRegion></affiliation></author><author><name sortKey="Chassany, Olivier" sort="Chassany, Olivier" uniqKey="Chassany O" first="Olivier" last="Chassany">Olivier Chassany</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lalanne, Christophe" sort="Lalanne, Christophe" uniqKey="Lalanne C" first="Christophe" last="Lalanne">Christophe Lalanne</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Da Silva, Mariliza Henrique" sort="Da Silva, Mariliza Henrique" uniqKey="Da Silva M" first="Mariliza Henrique" last="Da Silva">Mariliza Henrique Da Silva</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Galano, Eliana" sort="Galano, Eliana" uniqKey="Galano E" first="Eliana" last="Galano">Eliana Galano</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro de Referência e Treinamento DST/Aids, Rue santa Cruz, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Carrieri, Patrizia M" sort="Carrieri, Patrizia M" uniqKey="Carrieri P" first="Patrizia M" last="Carrieri">Patrizia M. Carrieri</name><affiliation wicri:level="3"><nlm:affiliation>U912 (SE4S), INSERM, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>U912 (SE4S), INSERM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Estellon, Vincent" sort="Estellon, Vincent" uniqKey="Estellon V" first="Vincent" last="Estellon">Vincent Estellon</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Sogni, Philippe" sort="Sogni, Philippe" uniqKey="Sogni P" first="Philippe" last="Sogni">Philippe Sogni</name><affiliation wicri:level="3"><nlm:affiliation>Service d'Hépatologie, Hopital Cochin, AP-HP, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépatologie, Hopital Cochin, AP-HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Duracinsky, Martin" sort="Duracinsky, Martin" uniqKey="Duracinsky M" first="Martin" last="Duracinsky">Martin Duracinsky</name><affiliation wicri:level="3"><nlm:affiliation>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EA 7334 REMES, Patient-Centered Outcomes Research, University Paris-Diderot, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">BMC infectious diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Australia</term><term>Brazil</term><term>Fatigue</term><term>Female</term><term>France</term><term>Health Status Indicators</term><term>Hepacivirus (physiology)</term><term>Hepatitis C (psychology)</term><term>Hepatitis C (therapy)</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Psychometrics (methods)</term><term>Psychometrics (standards)</term><term>Quality of Life (psychology)</term><term>Surveys and Questionnaires (standards)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Australie</term><term>Brésil</term><term>Coopération internationale</term><term>Enquêtes et questionnaires (normes)</term><term>Fatigue</term><term>Femelle</term><term>France</term><term>Hepacivirus (physiologie)</term><term>Humains</term><term>Hépatite C ()</term><term>Hépatite C (psychologie)</term><term>Indicateurs d'état de santé</term><term>Mâle</term><term>Projets pilotes</term><term>Psychométrie ()</term><term>Psychométrie (normes)</term><term>Qualité de vie (psychologie)</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Psychometrics</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Enquêtes et questionnaires</term><term>Psychométrie</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hepacivirus</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Hépatite C</term><term>Qualité de vie</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Hepatitis C</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Psychometrics</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hepatitis C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Australia</term><term>Brazil</term><term>Fatigue</term><term>Female</term><term>France</term><term>Health Status Indicators</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Australie</term><term>Brésil</term><term>Coopération internationale</term><term>Fatigue</term><term>Femelle</term><term>France</term><term>Humains</term><term>Hépatite C</term><term>Indicateurs d'état de santé</term><term>Mâle</term><term>Projets pilotes</term><term>Psychométrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatitis C virus (HCV) compromises Health-related Quality of Life (HRQL) with detriments to Physical, Mental and Social health domains. Treatment with interferon and ribavirin is associated with side effects which further impair HRQL. New treatments appear potent, effective and tolerable. However, Patient Reported Outcomes instruments that capture the impact on HRQL for people with hepatitis C are largely non-specific and will be needed in the new treatment era. Therefore, we developed a conceptually valid multidimensional model of HCV-specific quality of life and pilot survey instrument, the Patient Reported Outcome Quality of Life survey for HCV (PROQOL-HCV).</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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