Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future
Identifieur interne : 003983 ( Ncbi/Merge ); précédent : 003982; suivant : 003984Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future
Auteurs : Winnie De Bruijn [Pays-Bas] ; Cristina Ibá Ez [Espagne] ; Pia Frisk [Suède] ; Hanne Bak Pedersen [Danemark] ; Ali Alkan [Turquie] ; Patricia Vella Bonanno [Malte] ; Ljiljana S. Brki I [Croatie] ; Anna Bucsics [Autriche] ; Guillaume Dedet [France] ; Jaran Eriksen [Suède] ; Joseph O. Fadare [Nigeria] ; Jurij Fürst [Slovénie] ; Gisselle Gallego [Australie, Suède] ; Isabella P. God I [Brésil] ; Augusto A. Guerra Júnior [Brésil] ; Hakk Gürsöz [Turquie] ; Saira Jan [États-Unis] ; Jan Jones [Royaume-Uni] ; Roberta Joppi [Italie] ; Saim Kerman [Turquie] ; Ott Laius [Estonie] ; Newman Madzikwa [Zimbabwe] ; Einar Magnússon [Islande] ; Mojca Maticic [Slovénie] ; Vanda Markovic-Pekovic [Bosnie-Herzégovine] ; Amos Massele [Botswana] ; Olayinka Ogunleye [Nigeria] ; Aisling O'Leary [Irlande (pays)] ; Jutta Piessnegger [Autriche] ; Catherine Sermet [France] ; Steven Simoens [Belgique] ; Celda Tiroyakgosi [Botswana] ; Ilse Truter [Afrique du Sud] ; Magnus Thyberg [Suède] ; Kristina Tomekova [Slovaquie] ; Magdalena Wladysiuk [Pologne] ; Sotiris Vandoros [Royaume-Uni] ; Elif H. Vural [Turquie] ; Corinne Zara [Espagne] ; Brian Godman [Suède, Royaume-Uni]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2016.
Abstract
Url:
DOI: 10.3389/fphar.2016.00197
PubMed: 27516740
PubMed Central: 4964878
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Pharmaceutical Sciences, Utrecht University</institution><country>Utrecht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Public Health Services Committee, Stockholm County Council</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe</institution><country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Independent Pharmaceutical Consultant</institution><country>Mellieha, Malta</country></nlm:aff><country xml:lang="fr">Malte</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S." last="Brki I">Ljiljana S. 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Madzikwa</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Ministry of Health and Child Care</institution><country>Harrare, Zimbabwe</country></nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Health Services, Ministry of Health</institution><country>Reykjavík, Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Faculty of Medicine, University of Banja Luka</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Ministry of Health and Social Welfare</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Department of Clinical Pharmacology, School of Medicine, University of Botswana</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching Hospital</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Pharmacology and Therapeutics, Lagos State University College of Medicine</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>National Centre for Pharmacoeconomics</institution><country>Dublin, Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Hauptverband der Österreichischen Sozialversicherungsträger</institution><country>Wien, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>IRDES</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven</institution><country>Leuven, Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Ministry of Health, Nelson Mandela Drive</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University</institution><country>Port Elizabeth, South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Faculty of Management, Comenius University</institution><country>Bratislava, Slovakia</country></nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>HTA Consulting</institution><country>Cracow, Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>School of Management and Business, King's College London</institution><country>London, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H." last="Vural">Elif H. Vural</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27516740</idno><idno type="pmc">4964878</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964878</idno><idno type="RBID">PMC:4964878</idno><idno type="doi">10.3389/fphar.2016.00197</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000536</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000536</idno><idno type="wicri:Area/Pmc/Curation">000536</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000536</idno><idno type="wicri:Area/Pmc/Checkpoint">000826</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000826</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001C18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C18</idno><idno type="wicri:Area/PubMed/Curation">001B94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B94</idno><idno type="wicri:Area/PubMed/Checkpoint">001B94</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B94</idno><idno type="wicri:Area/Ncbi/Merge">003983</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Pharmaceutical Sciences, Utrecht University</institution><country>Utrecht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Public Health Services Committee, Stockholm County Council</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe</institution><country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Independent Pharmaceutical Consultant</institution><country>Mellieha, Malta</country></nlm:aff><country xml:lang="fr">Malte</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S." last="Brki I">Ljiljana S. Brki I</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Croatian Health Insurance Fund</institution><country>Zagreb, Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Finance, University of Vienna</institution><country>Vienna, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Ministry of Health</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O." last="Fadare">Joseph O. Fadare</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Pharmacology, Ekiti State University</institution><country>Ado-Ekiti, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Health Insurance Institute</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>School of Medicine, The University of Notre Dame Australia</institution><country>Darlinghurst, NSW, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Pharmacology and Clinical Neuroscience, Umea University</institution><country>Umea, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P." last="God I">Isabella P. God I</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Social Pharmacy, SUS Collaborating Centre – Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A." last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Social Pharmacy, SUS Collaborating Centre – Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Clinical Pharmacy, Rutgers State University of New Jersey</institution><country>Piscataway, NJ, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Horizon Blue Cross Blue Shield of New Jersey</institution><country>Newark, NJ, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Scottish Medicines Consortium</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona</institution><country>Verona, Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>State Agency of Medicines</institution><country>Tartu, Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Ministry of Health and Child Care</institution><country>Harrare, Zimbabwe</country></nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Health Services, Ministry of Health</institution><country>Reykjavík, Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Faculty of Medicine, University of Banja Luka</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Ministry of Health and Social Welfare</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Department of Clinical Pharmacology, School of Medicine, University of Botswana</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching Hospital</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Pharmacology and Therapeutics, Lagos State University College of Medicine</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>National Centre for Pharmacoeconomics</institution><country>Dublin, Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Hauptverband der Österreichischen Sozialversicherungsträger</institution><country>Wien, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>IRDES</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven</institution><country>Leuven, Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Ministry of Health, Nelson Mandela Drive</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University</institution><country>Port Elizabeth, South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Faculty of Management, Comenius University</institution><country>Bratislava, Slovakia</country></nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>HTA Consulting</institution><country>Cracow, Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>School of Management and Business, King's College London</institution><country>London, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H." last="Vural">Elif H. Vural</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens.</p><p><bold>Objective:</bold> Assess the uptake of BCV and TVR across Europe from a health authority perspective to offer future guidance on dealing with new high cost medicines.</p><p><bold>Methods:</bold> Cross-sectional descriptive study of medicines to treat HCV (pegIFN, ribavirin, BCV and TVR) among European countries from 2008 to 2013. Utilization measured in defined daily doses (DDDs)/1000 patients/quarter (DIQs) and expenditure in Euros/DDD. Health authority activities to influence treatments categorized using the 4E methodology (Education, Engineering, Economics and Enforcement).</p><p><bold>Results:</bold> Similar uptake of BCV and TVR among European countries and regions, ranging from 0.5 DIQ in Denmark, Netherlands and Slovenia to 1.5 DIQ in Tayside and Catalonia in 2013. However, different utilization of the new PIs vs. ribavirin indicates differences in dual vs. triple therapy, which is down to factors including physician preference and genotypes. Reimbursed prices for BCV and TVR were comparable across countries.</p><p><bold>Conclusion:</bold> There was reasonable consistency in the utilization of BCV and TVR among European countries in comparison with other high priced medicines. This may reflect the social demand to limit the transmission of HCV. However, the situation is changing with new curative medicines for HCV genotype 1 (GT1) with potentially an appreciable budget impact. These concerns have resulted in different prices across countries, with their impact on budgets and patient outcomes monitored in the future to provide additional guidance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adamski, J" uniqKey="Adamski J">J. Adamski</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Ofierska Sujkowska, G" uniqKey="Ofierska Sujkowska G">G. Ofierska-Sujkowska</name></author><author><name sortKey="Osi Ska, B" uniqKey="Osi Ska B">B. Osiñska</name></author><author><name sortKey="Herholz, H" uniqKey="Herholz H">H. Herholz</name></author><author><name sortKey="Wendykowska, K" uniqKey="Wendykowska K">K. Wendykowska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrieux Meyer, I" uniqKey="Andrieux Meyer I">I. Andrieux-Meyer</name></author><author><name sortKey="Cohn, J" uniqKey="Cohn J">J. Cohn</name></author><author><name sortKey="De Araujo, E S A" uniqKey="De Araujo E">E. S. A. de Araújo</name></author><author><name sortKey="Hamid, S S" uniqKey="Hamid S">S. S. Hamid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atun, R" uniqKey="Atun R">R. Atun</name></author><author><name sortKey="Ayd N, S" uniqKey="Ayd N S">S. Aydın</name></author><author><name sortKey="Chakraborty, S" uniqKey="Chakraborty S">S. Chakraborty</name></author><author><name sortKey="Sumer, S" uniqKey="Sumer S">S. Sümer</name></author><author><name sortKey="Aran, M" uniqKey="Aran M">M. Aran</name></author><author><name sortKey="Gurol, I" uniqKey="Gurol I">I. Gürol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aygen, B" uniqKey="Aygen B">B. Aygen</name></author><author><name sortKey="Y Ld Z, O" uniqKey="Y Ld Z O">O. Yıldız</name></author><author><name sortKey="Akhan, S" uniqKey="Akhan S">S. Akhan</name></author><author><name sortKey="Celen, M K" uniqKey="Celen M">M. K. Çelen</name></author><author><name sortKey="Ural, O" uniqKey="Ural O">O. Ural</name></author><author><name sortKey="Koruk, S T" uniqKey="Koruk S">S. T. Koruk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barua, S" uniqKey="Barua S">S. Barua</name></author><author><name sortKey="Greenwald, R" uniqKey="Greenwald R">R. Greenwald</name></author><author><name sortKey="Grebely, J" uniqKey="Grebely J">J. Grebely</name></author><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Swan, T" uniqKey="Swan T">T. Swan</name></author><author><name sortKey="Taylor, L E" uniqKey="Taylor L">L. E. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorkhem Bergman, L" uniqKey="Bjorkhem Bergman L">L. Björkhem-Bergman</name></author><author><name sortKey="Andersen Karlsson, E" uniqKey="Andersen Karlsson E">E. Andersén-Karlsson</name></author><author><name sortKey="Laing, R" uniqKey="Laing R">R. Laing</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Melien, O" uniqKey="Melien O">O. Melien</name></author><author><name sortKey="Jirlow, M" uniqKey="Jirlow M">M. Jirlow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, T" uniqKey="Brennan T">T. Brennan</name></author><author><name sortKey="Shrank, W" uniqKey="Shrank W">W. Shrank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brincat, A A" uniqKey="Brincat A">A. A. Brincat</name></author><author><name sortKey="Deguara, M" uniqKey="Deguara M">M. Deguara</name></author><author><name sortKey="Taliana, K" uniqKey="Taliana K">K. Taliana</name></author><author><name sortKey="Rogers, M" uniqKey="Rogers M">M. Rogers</name></author><author><name sortKey="Pocock, J" uniqKey="Pocock J">J. Pocock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cacace, M" uniqKey="Cacace M">M. Cacace</name></author><author><name sortKey="Ettelt, S" uniqKey="Ettelt S">S. Ettelt</name></author><author><name sortKey="Mays, N" uniqKey="Mays N">N. Mays</name></author><author><name sortKey="Nolte, E" uniqKey="Nolte E">E. Nolte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campbell, S M" uniqKey="Campbell S">S. M. Campbell</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Furst, J" uniqKey="Furst J">J. Fürst</name></author><author><name sortKey="Gustafsson, L L" uniqKey="Gustafsson L">L. L. Gustafsson</name></author><author><name sortKey="Macbride Stewart, S" uniqKey="Macbride Stewart S">S. MacBride-Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canary, L" uniqKey="Canary L">L. Canary</name></author><author><name sortKey="Klevens, R" uniqKey="Klevens R">R. Klevens</name></author><author><name sortKey="Holmberg, S" uniqKey="Holmberg S">S. Holmberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cebolla, B" uniqKey="Cebolla B">B. Cebolla</name></author><author><name sortKey="Bjornberg, A" uniqKey="Bjornberg A">A. Björnberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, E Y" uniqKey="Chen E">E. Y. Chen</name></author><author><name sortKey="Sclair, S N" uniqKey="Sclair S">S. N. Sclair</name></author><author><name sortKey="Czul, F" uniqKey="Czul F">F. Czul</name></author><author><name sortKey="Apica, B" uniqKey="Apica B">B. Apica</name></author><author><name sortKey="Dubin, P" uniqKey="Dubin P">P. Dubin</name></author><author><name sortKey="Martin, P" uniqKey="Martin P">P. Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Childs Kean, L M" uniqKey="Childs Kean L">L. M. Childs-Kean</name></author><author><name sortKey="Hand, E O" uniqKey="Hand E">E. O. Hand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, R" uniqKey="Chou R">R. Chou</name></author><author><name sortKey="Hartung, D" uniqKey="Hartung D">D. Hartung</name></author><author><name sortKey="Rahman, B" uniqKey="Rahman B">B. Rahman</name></author><author><name sortKey="Wasson, N" uniqKey="Wasson N">N. Wasson</name></author><author><name sortKey="Cottrell, E B" uniqKey="Cottrell E">E. B. Cottrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christensen, P B" uniqKey="Christensen P">P. B. Christensen</name></author><author><name sortKey="Clausen, M R" uniqKey="Clausen M">M. R. Clausen</name></author><author><name sortKey="Krarup, H" uniqKey="Krarup H">H. Krarup</name></author><author><name sortKey="Laursen, A L" uniqKey="Laursen A">A. L. Laursen</name></author><author><name sortKey="Schlichting, P" uniqKey="Schlichting P">P. Schlichting</name></author><author><name sortKey="Weis, N" uniqKey="Weis N">N. Weis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Civaner, M" uniqKey="Civaner M">M. Civaner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, J P" uniqKey="Cohen J">J. P. Cohen</name></author><author><name sortKey="Felix, A" uniqKey="Felix A">A. Felix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coma, A" uniqKey="Coma A">A. Coma</name></author><author><name sortKey="Zara, C" uniqKey="Zara C">C. Zara</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Agusti, A" uniqKey="Agusti A">A. Agustí</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogène</name></author><author><name sortKey="Wettermark, B" uniqKey="Wettermark B">B. Wettermark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornberg, M" uniqKey="Cornberg M">M. Cornberg</name></author><author><name sortKey="Razavi, H A" uniqKey="Razavi H">H. A. Razavi</name></author><author><name sortKey="Alberti, A" uniqKey="Alberti A">A. Alberti</name></author><author><name sortKey="Bernasconi, E" uniqKey="Bernasconi E">E. Bernasconi</name></author><author><name sortKey="Buti, M" uniqKey="Buti M">M. Buti</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cure, S" uniqKey="Cure S">S. Cure</name></author><author><name sortKey="Guerra, I" uniqKey="Guerra I">I. Guerra</name></author><author><name sortKey="Camma, C" uniqKey="Camma C">C. Cammà</name></author><author><name sortKey="Craxi, A" uniqKey="Craxi A">A. Craxì</name></author><author><name sortKey="Carosi, G" uniqKey="Carosi G">G. Carosi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deuffic Burban, S" uniqKey="Deuffic Burban S">S. Deuffic-Burban</name></author><author><name sortKey="Deltenre, P" uniqKey="Deltenre P">P. Deltenre</name></author><author><name sortKey="Buti, M" uniqKey="Buti M">M. Buti</name></author><author><name sortKey="Stroffolini, T" uniqKey="Stroffolini T">T. Stroffolini</name></author><author><name sortKey="Parkes, J" uniqKey="Parkes J">J. Parkes</name></author><author><name sortKey="Muhlberger, N" uniqKey="Muhlberger N">N. Mühlberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Ward, J" uniqKey="Ward J">J. Ward</name></author><author><name sortKey="Thursz, M" uniqKey="Thursz M">M. Thursz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ferrario, A" uniqKey="Ferrario A">A. Ferrario</name></author><author><name sortKey="Kanavos, P" uniqKey="Kanavos P">P. Kanavos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fojo, T" uniqKey="Fojo T">T. Fojo</name></author><author><name sortKey="Grady, C" uniqKey="Grady C">C. Grady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author><author><name sortKey="Swan, T" uniqKey="Swan T">T. Swan</name></author><author><name sortKey="Beyer, P" uniqKey="Beyer P">P. Beyer</name></author><author><name sortKey="Hirnschall, G" uniqKey="Hirnschall G">G. Hirnschall</name></author><author><name sortKey="Easterbrook, P" uniqKey="Easterbrook P">P. Easterbrook</name></author><author><name sortKey="Wiktor, S" uniqKey="Wiktor S">S. Wiktor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, I" uniqKey="Fraser I">I. Fraser</name></author><author><name sortKey="Burger, J" uniqKey="Burger J">J. Burger</name></author><author><name sortKey="Lubbe, M" uniqKey="Lubbe M">M. Lubbe</name></author><author><name sortKey="Dranitsaris, G" uniqKey="Dranitsaris G">G. Dranitsaris</name></author><author><name sortKey="Sonderup, M" uniqKey="Sonderup M">M. Sonderup</name></author><author><name sortKey="Stander, T" uniqKey="Stander T">T. Stander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garuoliene, K" uniqKey="Garuoliene K">K. Garuoliene</name></author><author><name sortKey="Alonderis, T" uniqKey="Alonderis T">T. Alonderis</name></author><author><name sortKey="Marcinkevic, M" uniqKey="Marcinkevic M">M. Marcinkevic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garuoliene, K" uniqKey="Garuoliene K">K. Garuoliene</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Gulbinovie, J" uniqKey="Gulbinovie J">J. Gulbinoviè</name></author><author><name sortKey="Wettermark, B" uniqKey="Wettermark B">B. Wettermark</name></author><author><name sortKey="Haycox, A" uniqKey="Haycox A">A. Haycox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghinea, N" uniqKey="Ghinea N">N. Ghinea</name></author><author><name sortKey="Kerridge, I" uniqKey="Kerridge I">I. Kerridge</name></author><author><name sortKey="Lipworth, W" uniqKey="Lipworth W">W. Lipworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Finlayson, A E" uniqKey="Finlayson A">A. E. Finlayson</name></author><author><name sortKey="Campbell, S" uniqKey="Campbell S">S. Campbell</name></author><author><name sortKey="Kwon, H Y" uniqKey="Kwon H">H.-Y. Kwon</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="De Bruyn, K" uniqKey="De Bruyn K">K. De Bruyn</name></author><author><name sortKey="Miranda, J" uniqKey="Miranda J">J. Miranda</name></author><author><name sortKey="Raschi, E" uniqKey="Raschi E">E. Raschi</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Barbui, C" uniqKey="Barbui C">C. Barbui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Malmstrom, R E" uniqKey="Malmstrom R">R. E. Malmström</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Gray, A" uniqKey="Gray A">A. Gray</name></author><author><name sortKey="Jayathissa, S" uniqKey="Jayathissa S">S. Jayathissa</name></author><author><name sortKey="Timoney, A" uniqKey="Timoney A">A. Timoney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Malmstrom, R E" uniqKey="Malmstrom R">R. E. Malmström</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Jayathissa, S" uniqKey="Jayathissa S">S. Jayathissa</name></author><author><name sortKey="Mctaggart, S" uniqKey="Mctaggart S">S. McTaggart</name></author><author><name sortKey="Cars, T" uniqKey="Cars T">T. Cars</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Petzold, M" uniqKey="Petzold M">M. Petzold</name></author><author><name sortKey="Bennett, K" uniqKey="Bennett K">K. Bennett</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Bucsics, A" uniqKey="Bucsics A">A. Bucsics</name></author><author><name sortKey="Finlayson, A E" uniqKey="Finlayson A">A. E. Finlayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Shrank, W" uniqKey="Shrank W">W. Shrank</name></author><author><name sortKey="Andersen, M" uniqKey="Andersen M">M. Andersen</name></author><author><name sortKey="Berg, C" uniqKey="Berg C">C. Berg</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Burkhardt, T" uniqKey="Burkhardt T">T. Burkhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Shrank, W" uniqKey="Shrank W">W. Shrank</name></author><author><name sortKey="Andersen, M" uniqKey="Andersen M">M. Andersen</name></author><author><name sortKey="Berg, C" uniqKey="Berg C">C. Berg</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Burkhardt, T" uniqKey="Burkhardt T">T. Burkhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gower, E" uniqKey="Gower E">E. Gower</name></author><author><name sortKey="Estes, C C" uniqKey="Estes C">C. C. Estes</name></author><author><name sortKey="Hindman, S" uniqKey="Hindman S">S. Hindman</name></author><author><name sortKey="Razavi Shearer, K" uniqKey="Razavi Shearer K">K. Razavi-Shearer</name></author><author><name sortKey="Razavi, H" uniqKey="Razavi H">H. Razavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hatzakis, A" uniqKey="Hatzakis A">A. Hatzakis</name></author><author><name sortKey="Wait, S" uniqKey="Wait S">S. Wait</name></author><author><name sortKey="Bruix, J" uniqKey="Bruix J">J. Bruix</name></author><author><name sortKey="Buti, M" uniqKey="Buti M">M. Buti</name></author><author><name sortKey="Carballo, M" uniqKey="Carballo M">M. Carballo</name></author><author><name sortKey="Cavaleri, M" uniqKey="Cavaleri M">M. Cavaleri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hesse, U" uniqKey="Hesse U">U. Hesse</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Petzold, M" uniqKey="Petzold M">M. Petzold</name></author><author><name sortKey="Martin, A" uniqKey="Martin A">A. Martin</name></author><author><name sortKey="Malmstrom, R" uniqKey="Malmstrom R">R. Malmström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hezode, C" uniqKey="Hezode C">C. Hézode</name></author><author><name sortKey="Fontaine, H" uniqKey="Fontaine H">H. Fontaine</name></author><author><name sortKey="Dorival, C" uniqKey="Dorival C">C. Dorival</name></author><author><name sortKey="Larrey, D" uniqKey="Larrey D">D. Larrey</name></author><author><name sortKey="Zoulim, F" uniqKey="Zoulim F">F. Zoulim</name></author><author><name sortKey="Canva, V" uniqKey="Canva V">V. Canva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hezode, C" uniqKey="Hezode C">C. Hézode</name></author><author><name sortKey="Fontaine, H" uniqKey="Fontaine H">H. Fontaine</name></author><author><name sortKey="Dorival, C" uniqKey="Dorival C">C. Dorival</name></author><author><name sortKey="Zoulim, F" uniqKey="Zoulim F">F. Zoulim</name></author><author><name sortKey="Larrey, D" uniqKey="Larrey D">D. Larrey</name></author><author><name sortKey="Canva, V" uniqKey="Canva V">V. Canva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hill, A" uniqKey="Hill A">A. Hill</name></author><author><name sortKey="Khoo, S" uniqKey="Khoo S">S. Khoo</name></author><author><name sortKey="Fortunak, J" uniqKey="Fortunak J">J. Fortunak</name></author><author><name sortKey="Simmons, B" uniqKey="Simmons B">B. Simmons</name></author><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoebert, J M" uniqKey="Hoebert J">J. M. Hoebert</name></author><author><name sortKey="Mantel Teeuwisse, A K" uniqKey="Mantel Teeuwisse A">A. K. Mantel-Teeuwisse</name></author><author><name sortKey="Van Dijk, L" uniqKey="Van Dijk L">L. van Dijk</name></author><author><name sortKey="Bijlsma, J W J" uniqKey="Bijlsma J">J. W. J. Bijlsma</name></author><author><name sortKey="Leufkens, H G M" uniqKey="Leufkens H">H. G. M. Leufkens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, W P" uniqKey="Hofmann W">W. P. Hofmann</name></author><author><name sortKey="Sarrazin, C" uniqKey="Sarrazin C">C. Sarrazin</name></author><author><name sortKey="Zeuzem, S" uniqKey="Zeuzem S">S. Zeuzem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hope, V D" uniqKey="Hope V">V. D. Hope</name></author><author><name sortKey="Eramova, I" uniqKey="Eramova I">I. Eramova</name></author><author><name sortKey="Capurro, D" uniqKey="Capurro D">D. Capurro</name></author><author><name sortKey="Donoghoe, M C" uniqKey="Donoghoe M">M. C. Donoghoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes Wilson, W" uniqKey="Hughes Wilson W">W. Hughes-Wilson</name></author><author><name sortKey="Palma, A" uniqKey="Palma A">A. Palma</name></author><author><name sortKey="Schuurman, A" uniqKey="Schuurman A">A. Schuurman</name></author><author><name sortKey="Simoens, S" uniqKey="Simoens S">S. Simoens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyengar, S" uniqKey="Iyengar S">S. Iyengar</name></author><author><name sortKey="Tay Teo, K" uniqKey="Tay Teo K">K. Tay-Teo</name></author><author><name sortKey="Vogler, S" uniqKey="Vogler S">S. Vogler</name></author><author><name sortKey="Beyer, P" uniqKey="Beyer P">P. Beyer</name></author><author><name sortKey="Wiktor, S" uniqKey="Wiktor S">S. Wiktor</name></author><author><name sortKey="De Joncheere, K" uniqKey="De Joncheere K">K. de Joncheere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonsson, B" uniqKey="Jonsson B">B. Jönsson</name></author><author><name sortKey="Ramsey, S" uniqKey="Ramsey S">S. Ramsey</name></author><author><name sortKey="Wilking, N" uniqKey="Wilking N">N. Wilking</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kantarjian, H M" uniqKey="Kantarjian H">H. M. Kantarjian</name></author><author><name sortKey="Fojo, T" uniqKey="Fojo T">T. Fojo</name></author><author><name sortKey="Mathisen, M" uniqKey="Mathisen M">M. Mathisen</name></author><author><name sortKey="Zwelling, L A" uniqKey="Zwelling L">L. A. Zwelling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohli, A" uniqKey="Kohli A">A. Kohli</name></author><author><name sortKey="Shaffer, A" uniqKey="Shaffer A">A. Shaffer</name></author><author><name sortKey="Sherman, A" uniqKey="Sherman A">A. Sherman</name></author><author><name sortKey="Kottilil, S" uniqKey="Kottilil S">S. Kottilil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lagging, M" uniqKey="Lagging M">M. Lagging</name></author><author><name sortKey="Duberg, A S" uniqKey="Duberg A">A.-S. Duberg</name></author><author><name sortKey="Wejst L, R" uniqKey="Wejst L R">R. Wejstål</name></author><author><name sortKey="Weiland, O" uniqKey="Weiland O">O. Weiland</name></author><author><name sortKey="Lindh, M" uniqKey="Lindh M">M. Lindh</name></author><author><name sortKey="Aleman, S" uniqKey="Aleman S">S. Aleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemoine, M" uniqKey="Lemoine M">M. Lemoine</name></author><author><name sortKey="Asia, E" uniqKey="Asia E">E. Asia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leroy, V" uniqKey="Leroy V">V. Leroy</name></author><author><name sortKey="Serfaty, L" uniqKey="Serfaty L">L. Serfaty</name></author><author><name sortKey="Bourliere, M" uniqKey="Bourliere M">M. Bourlière</name></author><author><name sortKey="Bronowicki, J P" uniqKey="Bronowicki J">J.-P. Bronowicki</name></author><author><name sortKey="Delasalle, P" uniqKey="Delasalle P">P. Delasalle</name></author><author><name sortKey="Pariente, A" uniqKey="Pariente A">A. Pariente</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo Re, V" uniqKey="Lo Re V">V. Lo Re</name></author><author><name sortKey="Teal, V" uniqKey="Teal V">V. Teal</name></author><author><name sortKey="Localio, A" uniqKey="Localio A">A. Localio</name></author><author><name sortKey="Amorosa, V" uniqKey="Amorosa V">V. Amorosa</name></author><author><name sortKey="Kaplan, D" uniqKey="Kaplan D">D. Kaplan</name></author><author><name sortKey="Gross, R" uniqKey="Gross R">R. Gross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lozano, R" uniqKey="Lozano R">R. Lozano</name></author><author><name sortKey="Naghavi, M" uniqKey="Naghavi M">M. Naghavi</name></author><author><name sortKey="Foreman, K" uniqKey="Foreman K">K. Foreman</name></author><author><name sortKey="Lim, S" uniqKey="Lim S">S. Lim</name></author><author><name sortKey="Shibuya, K" uniqKey="Shibuya K">K. Shibuya</name></author><author><name sortKey="Aboyans, V" uniqKey="Aboyans V">V. Aboyans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malmstrom, R E" uniqKey="Malmstrom R">R. E. Malmström</name></author><author><name sortKey="Godman, B B" uniqKey="Godman B">B. B. Godman</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Baumg Rtel, C" uniqKey="Baumg Rtel C">C. Baumgärtel</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manns, M P" uniqKey="Manns M">M. P. Manns</name></author><author><name sortKey="Pockros, P J" uniqKey="Pockros P">P. J. Pockros</name></author><author><name sortKey="Norkrans, G" uniqKey="Norkrans G">G. Norkrans</name></author><author><name sortKey="Smith, C I" uniqKey="Smith C">C. I. Smith</name></author><author><name sortKey="Morgan, T R" uniqKey="Morgan T">T. R. Morgan</name></author><author><name sortKey="H Ussinger, D" uniqKey="H Ussinger D">D. Häussinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manzano Robleda, M C" uniqKey="Manzano Robleda M">M. C. Manzano-Robleda</name></author><author><name sortKey="Ornelas Arroyo, V" uniqKey="Ornelas Arroyo V">V. Ornelas-arroyo</name></author><author><name sortKey="Barrientos Gutierrez, T" uniqKey="Barrientos Gutierrez T">T. Barrientos-gutiérrez</name></author><author><name sortKey="Mendez Sanchez, N" uniqKey="Mendez Sanchez N">N. Méndez-sánchez</name></author><author><name sortKey="Uribe, M" uniqKey="Uribe M">M. Uribe</name></author><author><name sortKey="Chavez Tapia, N C" uniqKey="Chavez Tapia N">N. C. Chávez-tapia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathurin, P" uniqKey="Mathurin P">P. Mathurin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maticic, M" uniqKey="Maticic M">M. Maticic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgowan, C E" uniqKey="Mcgowan C">C. E. McGowan</name></author><author><name sortKey="Monis, A" uniqKey="Monis A">A. Monis</name></author><author><name sortKey="Bacon, B R" uniqKey="Bacon B">B. R. Bacon</name></author><author><name sortKey="Mallolas, J" uniqKey="Mallolas J">J. Mallolas</name></author><author><name sortKey="Goncales, F L" uniqKey="Goncales F">F. L. Goncales</name></author><author><name sortKey="Goulis, I" uniqKey="Goulis I">I. Goulis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mchutchison, J G" uniqKey="Mchutchison J">J. G. McHutchison</name></author><author><name sortKey="Manns, M" uniqKey="Manns M">M. Manns</name></author><author><name sortKey="Patel, K" uniqKey="Patel K">K. Patel</name></author><author><name sortKey="Poynard, T" uniqKey="Poynard T">T. Poynard</name></author><author><name sortKey="Lindsay, K L" uniqKey="Lindsay K">K. L. Lindsay</name></author><author><name sortKey="Trepo, C" uniqKey="Trepo C">C. Trepo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mchutchison, J" uniqKey="Mchutchison J">J. McHutchison</name></author><author><name sortKey="Stuart, C" uniqKey="Stuart C">C. Stuart</name></author><author><name sortKey="Schiff, E" uniqKey="Schiff E">E. Schiff</name></author><author><name sortKey="Shiffman, M" uniqKey="Shiffman M">M. Shiffman</name></author><author><name sortKey="Lee, W" uniqKey="Lee W">W. Lee</name></author><author><name sortKey="Rustgi, V" uniqKey="Rustgi V">V. Rustgi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messina, J P" uniqKey="Messina J">J. P. Messina</name></author><author><name sortKey="Humphreys, I" uniqKey="Humphreys I">I. Humphreys</name></author><author><name sortKey="Flaxman, A" uniqKey="Flaxman A">A. Flaxman</name></author><author><name sortKey="Brown, A" uniqKey="Brown A">A. Brown</name></author><author><name sortKey="Cooke, G S" uniqKey="Cooke G">G. S. Cooke</name></author><author><name sortKey="Pybus, O G" uniqKey="Pybus O">O. G. Pybus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messori, A" uniqKey="Messori A">A. Messori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messori, A" uniqKey="Messori A">A. Messori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohd Hanafiah, K" uniqKey="Mohd Hanafiah K">K. Mohd Hanafiah</name></author><author><name sortKey="Groeger, J" uniqKey="Groeger J">J. Groeger</name></author><author><name sortKey="Flaxman, A D" uniqKey="Flaxman A">A. D. Flaxman</name></author><author><name sortKey="Wiersma, S T" uniqKey="Wiersma S">S. T. Wiersma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montazerhodjat, V" uniqKey="Montazerhodjat V">V. Montazerhodjat</name></author><author><name sortKey="Weinstock, D M" uniqKey="Weinstock D">D. M. Weinstock</name></author><author><name sortKey="Lo, A W" uniqKey="Lo A">A. W. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moon, J C" uniqKey="Moon J">J. C. Moon</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Petzold, M" uniqKey="Petzold M">M. Petzold</name></author><author><name sortKey="Alvarez Madrazo, S" uniqKey="Alvarez Madrazo S">S. Alvarez-Madrazo</name></author><author><name sortKey="Bennett, K" uniqKey="Bennett K">K. Bennett</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nolte, E" uniqKey="Nolte E">E. Nolte</name></author><author><name sortKey="Corbett, J" uniqKey="Corbett J">J. Corbett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norton, A" uniqKey="Norton A">A. Norton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orlent, H" uniqKey="Orlent H">H. Orlent</name></author><author><name sortKey="Deltenre, P" uniqKey="Deltenre P">P. Deltenre</name></author><author><name sortKey="Francque, S" uniqKey="Francque S">S. Francque</name></author><author><name sortKey="Laleman, W" uniqKey="Laleman W">W. Laleman</name></author><author><name sortKey="Moreno, C" uniqKey="Moreno C">C. Moreno</name></author><author><name sortKey="Bourgeois, S" uniqKey="Bourgeois S">S. Bourgeois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papastergiou, V" uniqKey="Papastergiou V">V. Papastergiou</name></author><author><name sortKey="Karatapanis, S" uniqKey="Karatapanis S">S. Karatapanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phelan, M" uniqKey="Phelan M">M. Phelan</name></author><author><name sortKey="Cook, C" uniqKey="Cook C">C. Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poynard, T" uniqKey="Poynard T">T. Poynard</name></author><author><name sortKey="Marcellin, P" uniqKey="Marcellin P">P. Marcellin</name></author><author><name sortKey="Lee, S S" uniqKey="Lee S">S. S. Lee</name></author><author><name sortKey="Niederau, C" uniqKey="Niederau C">C. Niederau</name></author><author><name sortKey="Minuk, G S" uniqKey="Minuk G">G. S. Minuk</name></author><author><name sortKey="Ideo, G" uniqKey="Ideo G">G. Ideo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Putrik, P" uniqKey="Putrik P">P. Putrik</name></author><author><name sortKey="Ramiro, S" uniqKey="Ramiro S">S. Ramiro</name></author><author><name sortKey="Kvien, T K" uniqKey="Kvien T">T. K. Kvien</name></author><author><name sortKey="Sokka, T" uniqKey="Sokka T">T. Sokka</name></author><author><name sortKey="Pavlova, M" uniqKey="Pavlova M">M. Pavlova</name></author><author><name sortKey="Uhlig, T" uniqKey="Uhlig T">T. Uhlig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramachandran, P" uniqKey="Ramachandran P">P. Ramachandran</name></author><author><name sortKey="Fraser, A" uniqKey="Fraser A">A. Fraser</name></author><author><name sortKey="Agarwal, K" uniqKey="Agarwal K">K. Agarwal</name></author><author><name sortKey="Austin, A" uniqKey="Austin A">A. Austin</name></author><author><name sortKey="Brown, A" uniqKey="Brown A">A. Brown</name></author><author><name sortKey="Foster, G R" uniqKey="Foster G">G. R. Foster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rein, D" uniqKey="Rein D">D. Rein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schalm, S W" uniqKey="Schalm S">S. W. Schalm</name></author><author><name sortKey="Hansen, B E" uniqKey="Hansen B">B. E. Hansen</name></author><author><name sortKey="Chemello, L" uniqKey="Chemello L">L. Chemello</name></author><author><name sortKey="Bellobuono, A" uniqKey="Bellobuono A">A. Bellobuono</name></author><author><name sortKey="Brouwer, J T" uniqKey="Brouwer J">J. T. Brouwer</name></author><author><name sortKey="Weiland, O" uniqKey="Weiland O">O. Weiland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Senior, M" uniqKey="Senior M">M. Senior</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simoens, S" uniqKey="Simoens S">S. Simoens</name></author><author><name sortKey="Picavet, E" uniqKey="Picavet E">E. Picavet</name></author><author><name sortKey="Dooms, M" uniqKey="Dooms M">M. Dooms</name></author><author><name sortKey="Cassiman, D" uniqKey="Cassiman D">D. Cassiman</name></author><author><name sortKey="Morel, T" uniqKey="Morel T">T. Morel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thein, H H" uniqKey="Thein H">H.-H. Thein</name></author><author><name sortKey="Yi, Q" uniqKey="Yi Q">Q. Yi</name></author><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Krahn, M D" uniqKey="Krahn M">M. D. Krahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trooskin, S B" uniqKey="Trooskin S">S. B. Trooskin</name></author><author><name sortKey="Reynolds, H" uniqKey="Reynolds H">H. Reynolds</name></author><author><name sortKey="Kostman, J R" uniqKey="Kostman J">J. R. Kostman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Ven, N" uniqKey="Van De Ven N">N. van de Ven</name></author><author><name sortKey="Fortunak, J" uniqKey="Fortunak J">J. Fortunak</name></author><author><name sortKey="Simmons, B" uniqKey="Simmons B">B. Simmons</name></author><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author><author><name sortKey="Cooke, G S" uniqKey="Cooke G">G. S. Cooke</name></author><author><name sortKey="Khoo, S" uniqKey="Khoo S">S. Khoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vogler, S" uniqKey="Vogler S">S. Vogler</name></author><author><name sortKey="Zimmermann, N" uniqKey="Zimmermann N">N. Zimmermann</name></author><author><name sortKey="Habl, C" uniqKey="Habl C">C. Habl</name></author><author><name sortKey="Mazag, J" uniqKey="Mazag J">J. Mazag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voneina, L" uniqKey="Voneina L">L. Vonèina</name></author><author><name sortKey="Strizrep, T" uniqKey="Strizrep T">T. Strizrep</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Campbell, S" uniqKey="Campbell S">S. Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wedemeyer, H" uniqKey="Wedemeyer H">H. Wedemeyer</name></author><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Ward, J W" uniqKey="Ward J">J. W. Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westbrook, R H" uniqKey="Westbrook R">R. H. Westbrook</name></author><author><name sortKey="Dusheiko, G" uniqKey="Dusheiko G">G. Dusheiko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wettermark, B" uniqKey="Wettermark B">B. Wettermark</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Jacobsson, B" uniqKey="Jacobsson B">B. Jacobsson</name></author><author><name sortKey="Haaijer Ruskamp, F M" uniqKey="Haaijer Ruskamp F">F. M. Haaijer-Ruskamp</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yehia, B R" uniqKey="Yehia B">B. R. Yehia</name></author><author><name sortKey="Schranz, A J" uniqKey="Schranz A">A. J. Schranz</name></author><author><name sortKey="Umscheid, C A" uniqKey="Umscheid C">C. A. Umscheid</name></author><author><name sortKey="Lo Re, V" uniqKey="Lo Re V">V. Lo Re</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z M" uniqKey="Younossi Z">Z. M. Younossi</name></author><author><name sortKey="Park, H" uniqKey="Park H">H. Park</name></author><author><name sortKey="Saab, S" uniqKey="Saab S">S. Saab</name></author><author><name sortKey="Ahmed, A" uniqKey="Ahmed A">A. Ahmed</name></author><author><name sortKey="Dieterich, D" uniqKey="Dieterich D">D. Dieterich</name></author><author><name sortKey="Gordon, S C" uniqKey="Gordon S">S. C. Gordon</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="27516740"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Pharmaceutical Sciences, Utrecht University</institution><country>Utrecht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Public Health Services Committee, Stockholm County Council</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe</institution><country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Independent Pharmaceutical Consultant</institution><country>Mellieha, Malta</country></nlm:aff><country xml:lang="fr">Malte</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S." last="Brki I">Ljiljana S. Brki I</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Croatian Health Insurance Fund</institution><country>Zagreb, Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Finance, University of Vienna</institution><country>Vienna, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Ministry of Health</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O." last="Fadare">Joseph O. Fadare</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Pharmacology, Ekiti State University</institution><country>Ado-Ekiti, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Health Insurance Institute</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>School of Medicine, The University of Notre Dame Australia</institution><country>Darlinghurst, NSW, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Pharmacology and Clinical Neuroscience, Umea University</institution><country>Umea, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P." last="God I">Isabella P. God I</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Social Pharmacy, SUS Collaborating Centre – Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A." last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Social Pharmacy, SUS Collaborating Centre – Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Clinical Pharmacy, Rutgers State University of New Jersey</institution><country>Piscataway, NJ, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Horizon Blue Cross Blue Shield of New Jersey</institution><country>Newark, NJ, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Scottish Medicines Consortium</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona</institution><country>Verona, Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>State Agency of Medicines</institution><country>Tartu, Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Ministry of Health and Child Care</institution><country>Harrare, Zimbabwe</country></nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Health Services, Ministry of Health</institution><country>Reykjavík, Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Faculty of Medicine, University of Banja Luka</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Ministry of Health and Social Welfare</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Department of Clinical Pharmacology, School of Medicine, University of Botswana</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching Hospital</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Pharmacology and Therapeutics, Lagos State University College of Medicine</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>National Centre for Pharmacoeconomics</institution><country>Dublin, Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Hauptverband der Österreichischen Sozialversicherungsträger</institution><country>Wien, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>IRDES</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven</institution><country>Leuven, Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Ministry of Health, Nelson Mandela Drive</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University</institution><country>Port Elizabeth, South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Faculty of Management, Comenius University</institution><country>Bratislava, Slovakia</country></nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>HTA Consulting</institution><country>Cracow, Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>School of Management and Business, King's College London</institution><country>London, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H." last="Vural">Elif H. Vural</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27516740</idno><idno type="pmc">4964878</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964878</idno><idno type="RBID">PMC:4964878</idno><idno type="doi">10.3389/fphar.2016.00197</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000536</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000536</idno><idno type="wicri:Area/Pmc/Curation">000536</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000536</idno><idno type="wicri:Area/Pmc/Checkpoint">000826</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000826</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Pharmaceutical Sciences, Utrecht University</institution><country>Utrecht, Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Public Health Services Committee, Stockholm County Council</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe</institution><country>Copenhagen, Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Independent Pharmaceutical Consultant</institution><country>Mellieha, Malta</country></nlm:aff><country xml:lang="fr">Malte</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S." last="Brki I">Ljiljana S. Brki I</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Croatian Health Insurance Fund</institution><country>Zagreb, Croatia</country></nlm:aff><country xml:lang="fr">Croatie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Finance, University of Vienna</institution><country>Vienna, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Ministry of Health</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O." last="Fadare">Joseph O. Fadare</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Pharmacology, Ekiti State University</institution><country>Ado-Ekiti, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Health Insurance Institute</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>School of Medicine, The University of Notre Dame Australia</institution><country>Darlinghurst, NSW, Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Pharmacology and Clinical Neuroscience, Umea University</institution><country>Umea, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P." last="God I">Isabella P. God I</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Social Pharmacy, SUS Collaborating Centre – Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A." last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Social Pharmacy, SUS Collaborating Centre – Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas Gerais</institution><country>Belo Horizonte, Brazil</country></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Clinical Pharmacy, Rutgers State University of New Jersey</institution><country>Piscataway, NJ, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Horizon Blue Cross Blue Shield of New Jersey</institution><country>Newark, NJ, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Scottish Medicines Consortium</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona</institution><country>Verona, Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>State Agency of Medicines</institution><country>Tartu, Estonia</country></nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Ministry of Health and Child Care</institution><country>Harrare, Zimbabwe</country></nlm:aff><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Health Services, Ministry of Health</institution><country>Reykjavík, Iceland</country></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana</institution><country>Ljubljana, Slovenia</country></nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Faculty of Medicine, University of Banja Luka</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Ministry of Health and Social Welfare</institution><country>Banja Luka, Bosnia and Herzegovina</country></nlm:aff><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Department of Clinical Pharmacology, School of Medicine, University of Botswana</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching Hospital</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Department of Pharmacology and Therapeutics, Lagos State University College of Medicine</institution><country>Lagos, Nigeria</country></nlm:aff><country xml:lang="fr">Nigeria</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>National Centre for Pharmacoeconomics</institution><country>Dublin, Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>Hauptverband der Österreichischen Sozialversicherungsträger</institution><country>Wien, Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>IRDES</institution><country>Paris, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven</institution><country>Leuven, Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Ministry of Health, Nelson Mandela Drive</institution><country>Gaborone, Botswana</country></nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University</institution><country>Port Elizabeth, South Africa</country></nlm:aff><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Faculty of Management, Comenius University</institution><country>Bratislava, Slovakia</country></nlm:aff><country xml:lang="fr">Slovaquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>HTA Consulting</institution><country>Cracow, Poland</country></nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>School of Management and Business, King's College London</institution><country>London, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H." last="Vural">Elif H. Vural</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Turkish Medicines and Medical Devices Agency, Ministry of Health</institution><country>Ankara, Turkey</country></nlm:aff><country xml:lang="fr">Turquie</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Catalan Health Service - Servei Català de la Salut</institution><country>Barcelona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge</institution><country>Stockholm, Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde</institution><country>Glasgow, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>, Santa Cruz</wicri:regionArea><wicri:noRegion>Santa Cruz</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens.</p><p><bold>Objective:</bold> Assess the uptake of BCV and TVR across Europe from a health authority perspective to offer future guidance on dealing with new high cost medicines.</p><p><bold>Methods:</bold> Cross-sectional descriptive study of medicines to treat HCV (pegIFN, ribavirin, BCV and TVR) among European countries from 2008 to 2013. Utilization measured in defined daily doses (DDDs)/1000 patients/quarter (DIQs) and expenditure in Euros/DDD. Health authority activities to influence treatments categorized using the 4E methodology (Education, Engineering, Economics and Enforcement).</p><p><bold>Results:</bold> Similar uptake of BCV and TVR among European countries and regions, ranging from 0.5 DIQ in Denmark, Netherlands and Slovenia to 1.5 DIQ in Tayside and Catalonia in 2013. However, different utilization of the new PIs vs. ribavirin indicates differences in dual vs. triple therapy, which is down to factors including physician preference and genotypes. Reimbursed prices for BCV and TVR were comparable across countries.</p><p><bold>Conclusion:</bold> There was reasonable consistency in the utilization of BCV and TVR among European countries in comparison with other high priced medicines. This may reflect the social demand to limit the transmission of HCV. However, the situation is changing with new curative medicines for HCV genotype 1 (GT1) with potentially an appreciable budget impact. These concerns have resulted in different prices across countries, with their impact on budgets and patient outcomes monitored in the future to provide additional guidance.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adamski, J" uniqKey="Adamski J">J. Adamski</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Ofierska Sujkowska, G" uniqKey="Ofierska Sujkowska G">G. Ofierska-Sujkowska</name></author><author><name sortKey="Osi Ska, B" uniqKey="Osi Ska B">B. Osiñska</name></author><author><name sortKey="Herholz, H" uniqKey="Herholz H">H. Herholz</name></author><author><name sortKey="Wendykowska, K" uniqKey="Wendykowska K">K. Wendykowska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andrieux Meyer, I" uniqKey="Andrieux Meyer I">I. Andrieux-Meyer</name></author><author><name sortKey="Cohn, J" uniqKey="Cohn J">J. Cohn</name></author><author><name sortKey="De Araujo, E S A" uniqKey="De Araujo E">E. S. A. de Araújo</name></author><author><name sortKey="Hamid, S S" uniqKey="Hamid S">S. S. Hamid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atun, R" uniqKey="Atun R">R. Atun</name></author><author><name sortKey="Ayd N, S" uniqKey="Ayd N S">S. Aydın</name></author><author><name sortKey="Chakraborty, S" uniqKey="Chakraborty S">S. Chakraborty</name></author><author><name sortKey="Sumer, S" uniqKey="Sumer S">S. Sümer</name></author><author><name sortKey="Aran, M" uniqKey="Aran M">M. Aran</name></author><author><name sortKey="Gurol, I" uniqKey="Gurol I">I. Gürol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aygen, B" uniqKey="Aygen B">B. Aygen</name></author><author><name sortKey="Y Ld Z, O" uniqKey="Y Ld Z O">O. Yıldız</name></author><author><name sortKey="Akhan, S" uniqKey="Akhan S">S. Akhan</name></author><author><name sortKey="Celen, M K" uniqKey="Celen M">M. K. Çelen</name></author><author><name sortKey="Ural, O" uniqKey="Ural O">O. Ural</name></author><author><name sortKey="Koruk, S T" uniqKey="Koruk S">S. T. Koruk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barua, S" uniqKey="Barua S">S. Barua</name></author><author><name sortKey="Greenwald, R" uniqKey="Greenwald R">R. Greenwald</name></author><author><name sortKey="Grebely, J" uniqKey="Grebely J">J. Grebely</name></author><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Swan, T" uniqKey="Swan T">T. Swan</name></author><author><name sortKey="Taylor, L E" uniqKey="Taylor L">L. E. Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorkhem Bergman, L" uniqKey="Bjorkhem Bergman L">L. Björkhem-Bergman</name></author><author><name sortKey="Andersen Karlsson, E" uniqKey="Andersen Karlsson E">E. Andersén-Karlsson</name></author><author><name sortKey="Laing, R" uniqKey="Laing R">R. Laing</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Melien, O" uniqKey="Melien O">O. Melien</name></author><author><name sortKey="Jirlow, M" uniqKey="Jirlow M">M. Jirlow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brennan, T" uniqKey="Brennan T">T. Brennan</name></author><author><name sortKey="Shrank, W" uniqKey="Shrank W">W. Shrank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brincat, A A" uniqKey="Brincat A">A. A. Brincat</name></author><author><name sortKey="Deguara, M" uniqKey="Deguara M">M. Deguara</name></author><author><name sortKey="Taliana, K" uniqKey="Taliana K">K. Taliana</name></author><author><name sortKey="Rogers, M" uniqKey="Rogers M">M. Rogers</name></author><author><name sortKey="Pocock, J" uniqKey="Pocock J">J. Pocock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cacace, M" uniqKey="Cacace M">M. Cacace</name></author><author><name sortKey="Ettelt, S" uniqKey="Ettelt S">S. Ettelt</name></author><author><name sortKey="Mays, N" uniqKey="Mays N">N. Mays</name></author><author><name sortKey="Nolte, E" uniqKey="Nolte E">E. Nolte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campbell, S M" uniqKey="Campbell S">S. M. Campbell</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Furst, J" uniqKey="Furst J">J. Fürst</name></author><author><name sortKey="Gustafsson, L L" uniqKey="Gustafsson L">L. L. Gustafsson</name></author><author><name sortKey="Macbride Stewart, S" uniqKey="Macbride Stewart S">S. MacBride-Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canary, L" uniqKey="Canary L">L. Canary</name></author><author><name sortKey="Klevens, R" uniqKey="Klevens R">R. Klevens</name></author><author><name sortKey="Holmberg, S" uniqKey="Holmberg S">S. Holmberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cebolla, B" uniqKey="Cebolla B">B. Cebolla</name></author><author><name sortKey="Bjornberg, A" uniqKey="Bjornberg A">A. Björnberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, E Y" uniqKey="Chen E">E. Y. Chen</name></author><author><name sortKey="Sclair, S N" uniqKey="Sclair S">S. N. Sclair</name></author><author><name sortKey="Czul, F" uniqKey="Czul F">F. Czul</name></author><author><name sortKey="Apica, B" uniqKey="Apica B">B. Apica</name></author><author><name sortKey="Dubin, P" uniqKey="Dubin P">P. Dubin</name></author><author><name sortKey="Martin, P" uniqKey="Martin P">P. Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Childs Kean, L M" uniqKey="Childs Kean L">L. M. Childs-Kean</name></author><author><name sortKey="Hand, E O" uniqKey="Hand E">E. O. Hand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, R" uniqKey="Chou R">R. Chou</name></author><author><name sortKey="Hartung, D" uniqKey="Hartung D">D. Hartung</name></author><author><name sortKey="Rahman, B" uniqKey="Rahman B">B. Rahman</name></author><author><name sortKey="Wasson, N" uniqKey="Wasson N">N. Wasson</name></author><author><name sortKey="Cottrell, E B" uniqKey="Cottrell E">E. B. Cottrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christensen, P B" uniqKey="Christensen P">P. B. Christensen</name></author><author><name sortKey="Clausen, M R" uniqKey="Clausen M">M. R. Clausen</name></author><author><name sortKey="Krarup, H" uniqKey="Krarup H">H. Krarup</name></author><author><name sortKey="Laursen, A L" uniqKey="Laursen A">A. L. Laursen</name></author><author><name sortKey="Schlichting, P" uniqKey="Schlichting P">P. Schlichting</name></author><author><name sortKey="Weis, N" uniqKey="Weis N">N. Weis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Civaner, M" uniqKey="Civaner M">M. Civaner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, J P" uniqKey="Cohen J">J. P. Cohen</name></author><author><name sortKey="Felix, A" uniqKey="Felix A">A. Felix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coma, A" uniqKey="Coma A">A. Coma</name></author><author><name sortKey="Zara, C" uniqKey="Zara C">C. Zara</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Agusti, A" uniqKey="Agusti A">A. Agustí</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogène</name></author><author><name sortKey="Wettermark, B" uniqKey="Wettermark B">B. Wettermark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cornberg, M" uniqKey="Cornberg M">M. Cornberg</name></author><author><name sortKey="Razavi, H A" uniqKey="Razavi H">H. A. Razavi</name></author><author><name sortKey="Alberti, A" uniqKey="Alberti A">A. Alberti</name></author><author><name sortKey="Bernasconi, E" uniqKey="Bernasconi E">E. Bernasconi</name></author><author><name sortKey="Buti, M" uniqKey="Buti M">M. Buti</name></author><author><name sortKey="Cooper, C" uniqKey="Cooper C">C. Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cure, S" uniqKey="Cure S">S. Cure</name></author><author><name sortKey="Guerra, I" uniqKey="Guerra I">I. Guerra</name></author><author><name sortKey="Camma, C" uniqKey="Camma C">C. Cammà</name></author><author><name sortKey="Craxi, A" uniqKey="Craxi A">A. Craxì</name></author><author><name sortKey="Carosi, G" uniqKey="Carosi G">G. Carosi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deuffic Burban, S" uniqKey="Deuffic Burban S">S. Deuffic-Burban</name></author><author><name sortKey="Deltenre, P" uniqKey="Deltenre P">P. Deltenre</name></author><author><name sortKey="Buti, M" uniqKey="Buti M">M. Buti</name></author><author><name sortKey="Stroffolini, T" uniqKey="Stroffolini T">T. Stroffolini</name></author><author><name sortKey="Parkes, J" uniqKey="Parkes J">J. Parkes</name></author><author><name sortKey="Muhlberger, N" uniqKey="Muhlberger N">N. Mühlberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Ward, J" uniqKey="Ward J">J. Ward</name></author><author><name sortKey="Thursz, M" uniqKey="Thursz M">M. Thursz</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ferrario, A" uniqKey="Ferrario A">A. Ferrario</name></author><author><name sortKey="Kanavos, P" uniqKey="Kanavos P">P. Kanavos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fojo, T" uniqKey="Fojo T">T. Fojo</name></author><author><name sortKey="Grady, C" uniqKey="Grady C">C. Grady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author><author><name sortKey="Swan, T" uniqKey="Swan T">T. Swan</name></author><author><name sortKey="Beyer, P" uniqKey="Beyer P">P. Beyer</name></author><author><name sortKey="Hirnschall, G" uniqKey="Hirnschall G">G. Hirnschall</name></author><author><name sortKey="Easterbrook, P" uniqKey="Easterbrook P">P. Easterbrook</name></author><author><name sortKey="Wiktor, S" uniqKey="Wiktor S">S. Wiktor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fraser, I" uniqKey="Fraser I">I. Fraser</name></author><author><name sortKey="Burger, J" uniqKey="Burger J">J. Burger</name></author><author><name sortKey="Lubbe, M" uniqKey="Lubbe M">M. Lubbe</name></author><author><name sortKey="Dranitsaris, G" uniqKey="Dranitsaris G">G. Dranitsaris</name></author><author><name sortKey="Sonderup, M" uniqKey="Sonderup M">M. Sonderup</name></author><author><name sortKey="Stander, T" uniqKey="Stander T">T. Stander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garuoliene, K" uniqKey="Garuoliene K">K. Garuoliene</name></author><author><name sortKey="Alonderis, T" uniqKey="Alonderis T">T. Alonderis</name></author><author><name sortKey="Marcinkevic, M" uniqKey="Marcinkevic M">M. Marcinkevic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garuoliene, K" uniqKey="Garuoliene K">K. Garuoliene</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Gulbinovie, J" uniqKey="Gulbinovie J">J. Gulbinoviè</name></author><author><name sortKey="Wettermark, B" uniqKey="Wettermark B">B. Wettermark</name></author><author><name sortKey="Haycox, A" uniqKey="Haycox A">A. Haycox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghinea, N" uniqKey="Ghinea N">N. Ghinea</name></author><author><name sortKey="Kerridge, I" uniqKey="Kerridge I">I. Kerridge</name></author><author><name sortKey="Lipworth, W" uniqKey="Lipworth W">W. Lipworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Finlayson, A E" uniqKey="Finlayson A">A. E. Finlayson</name></author><author><name sortKey="Campbell, S" uniqKey="Campbell S">S. Campbell</name></author><author><name sortKey="Kwon, H Y" uniqKey="Kwon H">H.-Y. Kwon</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="De Bruyn, K" uniqKey="De Bruyn K">K. De Bruyn</name></author><author><name sortKey="Miranda, J" uniqKey="Miranda J">J. Miranda</name></author><author><name sortKey="Raschi, E" uniqKey="Raschi E">E. Raschi</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Barbui, C" uniqKey="Barbui C">C. Barbui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Malmstrom, R E" uniqKey="Malmstrom R">R. E. Malmström</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Gray, A" uniqKey="Gray A">A. Gray</name></author><author><name sortKey="Jayathissa, S" uniqKey="Jayathissa S">S. Jayathissa</name></author><author><name sortKey="Timoney, A" uniqKey="Timoney A">A. Timoney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Malmstrom, R E" uniqKey="Malmstrom R">R. E. Malmström</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Jayathissa, S" uniqKey="Jayathissa S">S. Jayathissa</name></author><author><name sortKey="Mctaggart, S" uniqKey="Mctaggart S">S. McTaggart</name></author><author><name sortKey="Cars, T" uniqKey="Cars T">T. Cars</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Petzold, M" uniqKey="Petzold M">M. Petzold</name></author><author><name sortKey="Bennett, K" uniqKey="Bennett K">K. Bennett</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Bucsics, A" uniqKey="Bucsics A">A. Bucsics</name></author><author><name sortKey="Finlayson, A E" uniqKey="Finlayson A">A. E. Finlayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Shrank, W" uniqKey="Shrank W">W. Shrank</name></author><author><name sortKey="Andersen, M" uniqKey="Andersen M">M. Andersen</name></author><author><name sortKey="Berg, C" uniqKey="Berg C">C. Berg</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Burkhardt, T" uniqKey="Burkhardt T">T. Burkhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Shrank, W" uniqKey="Shrank W">W. Shrank</name></author><author><name sortKey="Andersen, M" uniqKey="Andersen M">M. Andersen</name></author><author><name sortKey="Berg, C" uniqKey="Berg C">C. Berg</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Burkhardt, T" uniqKey="Burkhardt T">T. Burkhardt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gower, E" uniqKey="Gower E">E. Gower</name></author><author><name sortKey="Estes, C C" uniqKey="Estes C">C. C. Estes</name></author><author><name sortKey="Hindman, S" uniqKey="Hindman S">S. Hindman</name></author><author><name sortKey="Razavi Shearer, K" uniqKey="Razavi Shearer K">K. Razavi-Shearer</name></author><author><name sortKey="Razavi, H" uniqKey="Razavi H">H. Razavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hatzakis, A" uniqKey="Hatzakis A">A. Hatzakis</name></author><author><name sortKey="Wait, S" uniqKey="Wait S">S. Wait</name></author><author><name sortKey="Bruix, J" uniqKey="Bruix J">J. Bruix</name></author><author><name sortKey="Buti, M" uniqKey="Buti M">M. Buti</name></author><author><name sortKey="Carballo, M" uniqKey="Carballo M">M. Carballo</name></author><author><name sortKey="Cavaleri, M" uniqKey="Cavaleri M">M. Cavaleri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hesse, U" uniqKey="Hesse U">U. Hesse</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Petzold, M" uniqKey="Petzold M">M. Petzold</name></author><author><name sortKey="Martin, A" uniqKey="Martin A">A. Martin</name></author><author><name sortKey="Malmstrom, R" uniqKey="Malmstrom R">R. Malmström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hezode, C" uniqKey="Hezode C">C. Hézode</name></author><author><name sortKey="Fontaine, H" uniqKey="Fontaine H">H. Fontaine</name></author><author><name sortKey="Dorival, C" uniqKey="Dorival C">C. Dorival</name></author><author><name sortKey="Larrey, D" uniqKey="Larrey D">D. Larrey</name></author><author><name sortKey="Zoulim, F" uniqKey="Zoulim F">F. Zoulim</name></author><author><name sortKey="Canva, V" uniqKey="Canva V">V. Canva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hezode, C" uniqKey="Hezode C">C. Hézode</name></author><author><name sortKey="Fontaine, H" uniqKey="Fontaine H">H. Fontaine</name></author><author><name sortKey="Dorival, C" uniqKey="Dorival C">C. Dorival</name></author><author><name sortKey="Zoulim, F" uniqKey="Zoulim F">F. Zoulim</name></author><author><name sortKey="Larrey, D" uniqKey="Larrey D">D. Larrey</name></author><author><name sortKey="Canva, V" uniqKey="Canva V">V. Canva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hill, A" uniqKey="Hill A">A. Hill</name></author><author><name sortKey="Khoo, S" uniqKey="Khoo S">S. Khoo</name></author><author><name sortKey="Fortunak, J" uniqKey="Fortunak J">J. Fortunak</name></author><author><name sortKey="Simmons, B" uniqKey="Simmons B">B. Simmons</name></author><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoebert, J M" uniqKey="Hoebert J">J. M. Hoebert</name></author><author><name sortKey="Mantel Teeuwisse, A K" uniqKey="Mantel Teeuwisse A">A. K. Mantel-Teeuwisse</name></author><author><name sortKey="Van Dijk, L" uniqKey="Van Dijk L">L. van Dijk</name></author><author><name sortKey="Bijlsma, J W J" uniqKey="Bijlsma J">J. W. J. Bijlsma</name></author><author><name sortKey="Leufkens, H G M" uniqKey="Leufkens H">H. G. M. Leufkens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, W P" uniqKey="Hofmann W">W. P. Hofmann</name></author><author><name sortKey="Sarrazin, C" uniqKey="Sarrazin C">C. Sarrazin</name></author><author><name sortKey="Zeuzem, S" uniqKey="Zeuzem S">S. Zeuzem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hope, V D" uniqKey="Hope V">V. D. Hope</name></author><author><name sortKey="Eramova, I" uniqKey="Eramova I">I. Eramova</name></author><author><name sortKey="Capurro, D" uniqKey="Capurro D">D. Capurro</name></author><author><name sortKey="Donoghoe, M C" uniqKey="Donoghoe M">M. C. Donoghoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes Wilson, W" uniqKey="Hughes Wilson W">W. Hughes-Wilson</name></author><author><name sortKey="Palma, A" uniqKey="Palma A">A. Palma</name></author><author><name sortKey="Schuurman, A" uniqKey="Schuurman A">A. Schuurman</name></author><author><name sortKey="Simoens, S" uniqKey="Simoens S">S. Simoens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iyengar, S" uniqKey="Iyengar S">S. Iyengar</name></author><author><name sortKey="Tay Teo, K" uniqKey="Tay Teo K">K. Tay-Teo</name></author><author><name sortKey="Vogler, S" uniqKey="Vogler S">S. Vogler</name></author><author><name sortKey="Beyer, P" uniqKey="Beyer P">P. Beyer</name></author><author><name sortKey="Wiktor, S" uniqKey="Wiktor S">S. Wiktor</name></author><author><name sortKey="De Joncheere, K" uniqKey="De Joncheere K">K. de Joncheere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonsson, B" uniqKey="Jonsson B">B. Jönsson</name></author><author><name sortKey="Ramsey, S" uniqKey="Ramsey S">S. Ramsey</name></author><author><name sortKey="Wilking, N" uniqKey="Wilking N">N. Wilking</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kantarjian, H M" uniqKey="Kantarjian H">H. M. Kantarjian</name></author><author><name sortKey="Fojo, T" uniqKey="Fojo T">T. Fojo</name></author><author><name sortKey="Mathisen, M" uniqKey="Mathisen M">M. Mathisen</name></author><author><name sortKey="Zwelling, L A" uniqKey="Zwelling L">L. A. Zwelling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohli, A" uniqKey="Kohli A">A. Kohli</name></author><author><name sortKey="Shaffer, A" uniqKey="Shaffer A">A. Shaffer</name></author><author><name sortKey="Sherman, A" uniqKey="Sherman A">A. Sherman</name></author><author><name sortKey="Kottilil, S" uniqKey="Kottilil S">S. Kottilil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lagging, M" uniqKey="Lagging M">M. Lagging</name></author><author><name sortKey="Duberg, A S" uniqKey="Duberg A">A.-S. Duberg</name></author><author><name sortKey="Wejst L, R" uniqKey="Wejst L R">R. Wejstål</name></author><author><name sortKey="Weiland, O" uniqKey="Weiland O">O. Weiland</name></author><author><name sortKey="Lindh, M" uniqKey="Lindh M">M. Lindh</name></author><author><name sortKey="Aleman, S" uniqKey="Aleman S">S. Aleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lemoine, M" uniqKey="Lemoine M">M. Lemoine</name></author><author><name sortKey="Asia, E" uniqKey="Asia E">E. Asia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leroy, V" uniqKey="Leroy V">V. Leroy</name></author><author><name sortKey="Serfaty, L" uniqKey="Serfaty L">L. Serfaty</name></author><author><name sortKey="Bourliere, M" uniqKey="Bourliere M">M. Bourlière</name></author><author><name sortKey="Bronowicki, J P" uniqKey="Bronowicki J">J.-P. Bronowicki</name></author><author><name sortKey="Delasalle, P" uniqKey="Delasalle P">P. Delasalle</name></author><author><name sortKey="Pariente, A" uniqKey="Pariente A">A. Pariente</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo Re, V" uniqKey="Lo Re V">V. Lo Re</name></author><author><name sortKey="Teal, V" uniqKey="Teal V">V. Teal</name></author><author><name sortKey="Localio, A" uniqKey="Localio A">A. Localio</name></author><author><name sortKey="Amorosa, V" uniqKey="Amorosa V">V. Amorosa</name></author><author><name sortKey="Kaplan, D" uniqKey="Kaplan D">D. Kaplan</name></author><author><name sortKey="Gross, R" uniqKey="Gross R">R. Gross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lozano, R" uniqKey="Lozano R">R. Lozano</name></author><author><name sortKey="Naghavi, M" uniqKey="Naghavi M">M. Naghavi</name></author><author><name sortKey="Foreman, K" uniqKey="Foreman K">K. Foreman</name></author><author><name sortKey="Lim, S" uniqKey="Lim S">S. Lim</name></author><author><name sortKey="Shibuya, K" uniqKey="Shibuya K">K. Shibuya</name></author><author><name sortKey="Aboyans, V" uniqKey="Aboyans V">V. Aboyans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malmstrom, R E" uniqKey="Malmstrom R">R. E. Malmström</name></author><author><name sortKey="Godman, B B" uniqKey="Godman B">B. B. Godman</name></author><author><name sortKey="Diogene, E" uniqKey="Diogene E">E. Diogene</name></author><author><name sortKey="Baumg Rtel, C" uniqKey="Baumg Rtel C">C. Baumgärtel</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manns, M P" uniqKey="Manns M">M. P. Manns</name></author><author><name sortKey="Pockros, P J" uniqKey="Pockros P">P. J. Pockros</name></author><author><name sortKey="Norkrans, G" uniqKey="Norkrans G">G. Norkrans</name></author><author><name sortKey="Smith, C I" uniqKey="Smith C">C. I. Smith</name></author><author><name sortKey="Morgan, T R" uniqKey="Morgan T">T. R. Morgan</name></author><author><name sortKey="H Ussinger, D" uniqKey="H Ussinger D">D. Häussinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manzano Robleda, M C" uniqKey="Manzano Robleda M">M. C. Manzano-Robleda</name></author><author><name sortKey="Ornelas Arroyo, V" uniqKey="Ornelas Arroyo V">V. Ornelas-arroyo</name></author><author><name sortKey="Barrientos Gutierrez, T" uniqKey="Barrientos Gutierrez T">T. Barrientos-gutiérrez</name></author><author><name sortKey="Mendez Sanchez, N" uniqKey="Mendez Sanchez N">N. Méndez-sánchez</name></author><author><name sortKey="Uribe, M" uniqKey="Uribe M">M. Uribe</name></author><author><name sortKey="Chavez Tapia, N C" uniqKey="Chavez Tapia N">N. C. Chávez-tapia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathurin, P" uniqKey="Mathurin P">P. Mathurin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maticic, M" uniqKey="Maticic M">M. Maticic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgowan, C E" uniqKey="Mcgowan C">C. E. McGowan</name></author><author><name sortKey="Monis, A" uniqKey="Monis A">A. Monis</name></author><author><name sortKey="Bacon, B R" uniqKey="Bacon B">B. R. Bacon</name></author><author><name sortKey="Mallolas, J" uniqKey="Mallolas J">J. Mallolas</name></author><author><name sortKey="Goncales, F L" uniqKey="Goncales F">F. L. Goncales</name></author><author><name sortKey="Goulis, I" uniqKey="Goulis I">I. Goulis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mchutchison, J G" uniqKey="Mchutchison J">J. G. McHutchison</name></author><author><name sortKey="Manns, M" uniqKey="Manns M">M. Manns</name></author><author><name sortKey="Patel, K" uniqKey="Patel K">K. Patel</name></author><author><name sortKey="Poynard, T" uniqKey="Poynard T">T. Poynard</name></author><author><name sortKey="Lindsay, K L" uniqKey="Lindsay K">K. L. Lindsay</name></author><author><name sortKey="Trepo, C" uniqKey="Trepo C">C. Trepo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mchutchison, J" uniqKey="Mchutchison J">J. McHutchison</name></author><author><name sortKey="Stuart, C" uniqKey="Stuart C">C. Stuart</name></author><author><name sortKey="Schiff, E" uniqKey="Schiff E">E. Schiff</name></author><author><name sortKey="Shiffman, M" uniqKey="Shiffman M">M. Shiffman</name></author><author><name sortKey="Lee, W" uniqKey="Lee W">W. Lee</name></author><author><name sortKey="Rustgi, V" uniqKey="Rustgi V">V. Rustgi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messina, J P" uniqKey="Messina J">J. P. Messina</name></author><author><name sortKey="Humphreys, I" uniqKey="Humphreys I">I. Humphreys</name></author><author><name sortKey="Flaxman, A" uniqKey="Flaxman A">A. Flaxman</name></author><author><name sortKey="Brown, A" uniqKey="Brown A">A. Brown</name></author><author><name sortKey="Cooke, G S" uniqKey="Cooke G">G. S. Cooke</name></author><author><name sortKey="Pybus, O G" uniqKey="Pybus O">O. G. Pybus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messori, A" uniqKey="Messori A">A. Messori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Messori, A" uniqKey="Messori A">A. Messori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohd Hanafiah, K" uniqKey="Mohd Hanafiah K">K. Mohd Hanafiah</name></author><author><name sortKey="Groeger, J" uniqKey="Groeger J">J. Groeger</name></author><author><name sortKey="Flaxman, A D" uniqKey="Flaxman A">A. D. Flaxman</name></author><author><name sortKey="Wiersma, S T" uniqKey="Wiersma S">S. T. Wiersma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montazerhodjat, V" uniqKey="Montazerhodjat V">V. Montazerhodjat</name></author><author><name sortKey="Weinstock, D M" uniqKey="Weinstock D">D. M. Weinstock</name></author><author><name sortKey="Lo, A W" uniqKey="Lo A">A. W. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moon, J C" uniqKey="Moon J">J. C. Moon</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Petzold, M" uniqKey="Petzold M">M. Petzold</name></author><author><name sortKey="Alvarez Madrazo, S" uniqKey="Alvarez Madrazo S">S. Alvarez-Madrazo</name></author><author><name sortKey="Bennett, K" uniqKey="Bennett K">K. Bennett</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nolte, E" uniqKey="Nolte E">E. Nolte</name></author><author><name sortKey="Corbett, J" uniqKey="Corbett J">J. Corbett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norton, A" uniqKey="Norton A">A. Norton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orlent, H" uniqKey="Orlent H">H. Orlent</name></author><author><name sortKey="Deltenre, P" uniqKey="Deltenre P">P. Deltenre</name></author><author><name sortKey="Francque, S" uniqKey="Francque S">S. Francque</name></author><author><name sortKey="Laleman, W" uniqKey="Laleman W">W. Laleman</name></author><author><name sortKey="Moreno, C" uniqKey="Moreno C">C. Moreno</name></author><author><name sortKey="Bourgeois, S" uniqKey="Bourgeois S">S. Bourgeois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papastergiou, V" uniqKey="Papastergiou V">V. Papastergiou</name></author><author><name sortKey="Karatapanis, S" uniqKey="Karatapanis S">S. Karatapanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phelan, M" uniqKey="Phelan M">M. Phelan</name></author><author><name sortKey="Cook, C" uniqKey="Cook C">C. Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poynard, T" uniqKey="Poynard T">T. Poynard</name></author><author><name sortKey="Marcellin, P" uniqKey="Marcellin P">P. Marcellin</name></author><author><name sortKey="Lee, S S" uniqKey="Lee S">S. S. Lee</name></author><author><name sortKey="Niederau, C" uniqKey="Niederau C">C. Niederau</name></author><author><name sortKey="Minuk, G S" uniqKey="Minuk G">G. S. Minuk</name></author><author><name sortKey="Ideo, G" uniqKey="Ideo G">G. Ideo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Putrik, P" uniqKey="Putrik P">P. Putrik</name></author><author><name sortKey="Ramiro, S" uniqKey="Ramiro S">S. Ramiro</name></author><author><name sortKey="Kvien, T K" uniqKey="Kvien T">T. K. Kvien</name></author><author><name sortKey="Sokka, T" uniqKey="Sokka T">T. Sokka</name></author><author><name sortKey="Pavlova, M" uniqKey="Pavlova M">M. Pavlova</name></author><author><name sortKey="Uhlig, T" uniqKey="Uhlig T">T. Uhlig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramachandran, P" uniqKey="Ramachandran P">P. Ramachandran</name></author><author><name sortKey="Fraser, A" uniqKey="Fraser A">A. Fraser</name></author><author><name sortKey="Agarwal, K" uniqKey="Agarwal K">K. Agarwal</name></author><author><name sortKey="Austin, A" uniqKey="Austin A">A. Austin</name></author><author><name sortKey="Brown, A" uniqKey="Brown A">A. Brown</name></author><author><name sortKey="Foster, G R" uniqKey="Foster G">G. R. Foster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rein, D" uniqKey="Rein D">D. Rein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schalm, S W" uniqKey="Schalm S">S. W. Schalm</name></author><author><name sortKey="Hansen, B E" uniqKey="Hansen B">B. E. Hansen</name></author><author><name sortKey="Chemello, L" uniqKey="Chemello L">L. Chemello</name></author><author><name sortKey="Bellobuono, A" uniqKey="Bellobuono A">A. Bellobuono</name></author><author><name sortKey="Brouwer, J T" uniqKey="Brouwer J">J. T. Brouwer</name></author><author><name sortKey="Weiland, O" uniqKey="Weiland O">O. Weiland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Senior, M" uniqKey="Senior M">M. Senior</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simoens, S" uniqKey="Simoens S">S. Simoens</name></author><author><name sortKey="Picavet, E" uniqKey="Picavet E">E. Picavet</name></author><author><name sortKey="Dooms, M" uniqKey="Dooms M">M. Dooms</name></author><author><name sortKey="Cassiman, D" uniqKey="Cassiman D">D. Cassiman</name></author><author><name sortKey="Morel, T" uniqKey="Morel T">T. Morel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thein, H H" uniqKey="Thein H">H.-H. Thein</name></author><author><name sortKey="Yi, Q" uniqKey="Yi Q">Q. Yi</name></author><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Krahn, M D" uniqKey="Krahn M">M. D. Krahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trooskin, S B" uniqKey="Trooskin S">S. B. Trooskin</name></author><author><name sortKey="Reynolds, H" uniqKey="Reynolds H">H. Reynolds</name></author><author><name sortKey="Kostman, J R" uniqKey="Kostman J">J. R. Kostman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Ven, N" uniqKey="Van De Ven N">N. van de Ven</name></author><author><name sortKey="Fortunak, J" uniqKey="Fortunak J">J. Fortunak</name></author><author><name sortKey="Simmons, B" uniqKey="Simmons B">B. Simmons</name></author><author><name sortKey="Ford, N" uniqKey="Ford N">N. Ford</name></author><author><name sortKey="Cooke, G S" uniqKey="Cooke G">G. S. Cooke</name></author><author><name sortKey="Khoo, S" uniqKey="Khoo S">S. Khoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vogler, S" uniqKey="Vogler S">S. Vogler</name></author><author><name sortKey="Zimmermann, N" uniqKey="Zimmermann N">N. Zimmermann</name></author><author><name sortKey="Habl, C" uniqKey="Habl C">C. Habl</name></author><author><name sortKey="Mazag, J" uniqKey="Mazag J">J. Mazag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voneina, L" uniqKey="Voneina L">L. Vonèina</name></author><author><name sortKey="Strizrep, T" uniqKey="Strizrep T">T. Strizrep</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Bennie, M" uniqKey="Bennie M">M. Bennie</name></author><author><name sortKey="Bishop, I" uniqKey="Bishop I">I. Bishop</name></author><author><name sortKey="Campbell, S" uniqKey="Campbell S">S. Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wedemeyer, H" uniqKey="Wedemeyer H">H. Wedemeyer</name></author><author><name sortKey="Dore, G J" uniqKey="Dore G">G. J. Dore</name></author><author><name sortKey="Ward, J W" uniqKey="Ward J">J. W. Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westbrook, R H" uniqKey="Westbrook R">R. H. Westbrook</name></author><author><name sortKey="Dusheiko, G" uniqKey="Dusheiko G">G. Dusheiko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wettermark, B" uniqKey="Wettermark B">B. Wettermark</name></author><author><name sortKey="Godman, B" uniqKey="Godman B">B. Godman</name></author><author><name sortKey="Jacobsson, B" uniqKey="Jacobsson B">B. Jacobsson</name></author><author><name sortKey="Haaijer Ruskamp, F M" uniqKey="Haaijer Ruskamp F">F. M. Haaijer-Ruskamp</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yehia, B R" uniqKey="Yehia B">B. R. Yehia</name></author><author><name sortKey="Schranz, A J" uniqKey="Schranz A">A. J. Schranz</name></author><author><name sortKey="Umscheid, C A" uniqKey="Umscheid C">C. A. Umscheid</name></author><author><name sortKey="Lo Re, V" uniqKey="Lo Re V">V. Lo Re</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Younossi, Z M" uniqKey="Younossi Z">Z. M. Younossi</name></author><author><name sortKey="Park, H" uniqKey="Park H">H. Park</name></author><author><name sortKey="Saab, S" uniqKey="Saab S">S. Saab</name></author><author><name sortKey="Ahmed, A" uniqKey="Ahmed A">A. Ahmed</name></author><author><name sortKey="Dieterich, D" uniqKey="Dieterich D">D. Dieterich</name></author><author><name sortKey="Gordon, S C" uniqKey="Gordon S">S. C. Gordon</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, Utrecht University Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pharmaceutical Sciences, Utrecht University Utrecht</wicri:regionArea><wicri:noRegion>Utrecht University Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation wicri:level="1"><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Health Service - Servei Català de la Salut Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Services Committee, Stockholm County Council Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Public Health Services Committee, Stockholm County Council Stockholm</wicri:regionArea><wicri:noRegion>Stockholm County Council Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation wicri:level="1"><nlm:affiliation>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen</wicri:regionArea><wicri:noRegion>WHO Regional Office for Europe Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation wicri:level="1"><nlm:affiliation>Independent Pharmaceutical Consultant Mellieha, Malta.</nlm:affiliation><country xml:lang="fr">Malte</country><wicri:regionArea>Independent Pharmaceutical Consultant Mellieha</wicri:regionArea></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S" last="Brki I">Ljiljana S. Brki I</name><affiliation wicri:level="1"><nlm:affiliation>Croatian Health Insurance Fund Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Health Insurance Fund Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation wicri:level="1"><nlm:affiliation>Department of Finance, University of Vienna Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Finance, University of Vienna Vienna</wicri:regionArea><wicri:noRegion>University of Vienna Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ministry of Health Paris</wicri:regionArea></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm</wicri:regionArea><wicri:noRegion>Karolinska University Hospital Huddinge Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O" last="Fadare">Joseph O. Fadare</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Ekiti State University Ado-Ekiti, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacology, Ekiti State University Ado-Ekiti</wicri:regionArea><wicri:noRegion>Ekiti State University Ado-Ekiti</wicri:noRegion></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation wicri:level="1"><nlm:affiliation>Health Insurance Institute Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Health Insurance Institute Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea</wicri:regionArea><wicri:noRegion>Umea UniversityUmea</wicri:noRegion></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P" last="God I">Isabella P. God I</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte</wicri:regionArea><wicri:noRegion>Federal University of Minas GeraisBelo Horizonte</wicri:noRegion></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A" last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte</wicri:regionArea><wicri:noRegion>Federal University of Minas GeraisBelo Horizonte</wicri:noRegion></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation wicri:level="1"><nlm:affiliation>Scottish Medicines Consortium Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Scottish Medicines Consortium Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation wicri:level="1"><nlm:affiliation>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona</wicri:regionArea><wicri:noRegion>Azienda Sanitaria Locale of Verona Verona</wicri:noRegion></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation wicri:level="1"><nlm:affiliation>State Agency of Medicines Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>State Agency of Medicines Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health and Child Care Harrare, Zimbabwe.</nlm:affiliation><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Ministry of Health and Child Care Harrare</wicri:regionArea></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Services, Ministry of Health Reykjavík, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Health Services, Ministry of Health Reykjavík</wicri:regionArea><wicri:noRegion>Ministry of Health Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation wicri:level="1"><nlm:affiliation>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana</wicri:regionArea><wicri:noRegion>University Medical Centre Ljubljana Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka, Bosnia and Herzegovina.</nlm:affiliation><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka</wicri:regionArea><wicri:noRegion>Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka</wicri:noRegion></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone, Botswana.</nlm:affiliation><country xml:lang="fr">Botswana</country><wicri:regionArea>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone</wicri:regionArea><wicri:noRegion>University of Botswana Gaborone</wicri:noRegion></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos</wicri:regionArea><wicri:noRegion>Lagos State University College of MedicineLagos</wicri:noRegion></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation wicri:level="1"><nlm:affiliation>National Centre for Pharmacoeconomics Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National Centre for Pharmacoeconomics Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation wicri:level="1"><nlm:affiliation>Hauptverband der Österreichischen Sozialversicherungsträger Wien, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Hauptverband der Österreichischen Sozialversicherungsträger Wien</wicri:regionArea></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation wicri:level="1"><nlm:affiliation>IRDES Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IRDES Paris</wicri:regionArea></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven</wicri:regionArea><wicri:noRegion>KU Leuven Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health, Nelson Mandela Drive Gaborone, Botswana.</nlm:affiliation><country xml:lang="fr">Botswana</country><wicri:regionArea>Ministry of Health, Nelson Mandela Drive Gaborone</wicri:regionArea><wicri:noRegion>Nelson Mandela Drive Gaborone</wicri:noRegion></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation wicri:level="1"><nlm:affiliation>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth</wicri:regionArea><wicri:noRegion>Nelson Mandela Metropolitan University Port Elizabeth</wicri:noRegion></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation wicri:level="1"><nlm:affiliation>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm</wicri:regionArea><wicri:noRegion>Hälso-och Sjukvårdsförvaltningen Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Management, Comenius University Bratislava, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Faculty of Management, Comenius University Bratislava</wicri:regionArea><wicri:noRegion>Comenius University Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation wicri:level="1"><nlm:affiliation>HTA Consulting Cracow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>HTA Consulting Cracow</wicri:regionArea></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation wicri:level="1"><nlm:affiliation>School of Management and Business, King's College London London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Management and Business, King's College London London</wicri:regionArea><wicri:noRegion>King's College London London</wicri:noRegion></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H" last="Vural">Elif H. Vural</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation wicri:level="1"><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Health Service - Servei Català de la Salut Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow</wicri:regionArea><wicri:noRegion>University of StrathclydeGlasgow</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27516740</idno><idno type="pmid">27516740</idno><idno type="doi">10.3389/fphar.2016.00197</idno><idno type="wicri:Area/PubMed/Corpus">001C18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C18</idno><idno type="wicri:Area/PubMed/Curation">001B94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B94</idno><idno type="wicri:Area/PubMed/Checkpoint">001B94</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical Sciences, Utrecht University Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pharmaceutical Sciences, Utrecht University Utrecht</wicri:regionArea><wicri:noRegion>Utrecht University Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation wicri:level="1"><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Health Service - Servei Català de la Salut Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Services Committee, Stockholm County Council Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Public Health Services Committee, Stockholm County Council Stockholm</wicri:regionArea><wicri:noRegion>Stockholm County Council Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation wicri:level="1"><nlm:affiliation>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen</wicri:regionArea><wicri:noRegion>WHO Regional Office for Europe Copenhagen</wicri:noRegion></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation wicri:level="1"><nlm:affiliation>Independent Pharmaceutical Consultant Mellieha, Malta.</nlm:affiliation><country xml:lang="fr">Malte</country><wicri:regionArea>Independent Pharmaceutical Consultant Mellieha</wicri:regionArea></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S" last="Brki I">Ljiljana S. Brki I</name><affiliation wicri:level="1"><nlm:affiliation>Croatian Health Insurance Fund Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>Croatian Health Insurance Fund Zagreb</wicri:regionArea></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation wicri:level="1"><nlm:affiliation>Department of Finance, University of Vienna Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Finance, University of Vienna Vienna</wicri:regionArea><wicri:noRegion>University of Vienna Vienna</wicri:noRegion></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Ministry of Health Paris</wicri:regionArea></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm</wicri:regionArea><wicri:noRegion>Karolinska University Hospital Huddinge Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O" last="Fadare">Joseph O. Fadare</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Ekiti State University Ado-Ekiti, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacology, Ekiti State University Ado-Ekiti</wicri:regionArea><wicri:noRegion>Ekiti State University Ado-Ekiti</wicri:noRegion></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation wicri:level="1"><nlm:affiliation>Health Insurance Institute Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Health Insurance Institute Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea</wicri:regionArea><wicri:noRegion>Umea UniversityUmea</wicri:noRegion></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P" last="God I">Isabella P. God I</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte</wicri:regionArea><wicri:noRegion>Federal University of Minas GeraisBelo Horizonte</wicri:noRegion></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A" last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte</wicri:regionArea><wicri:noRegion>Federal University of Minas GeraisBelo Horizonte</wicri:noRegion></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation wicri:level="2"><nlm:affiliation>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation wicri:level="1"><nlm:affiliation>Scottish Medicines Consortium Glasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Scottish Medicines Consortium Glasgow</wicri:regionArea></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation wicri:level="1"><nlm:affiliation>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona</wicri:regionArea><wicri:noRegion>Azienda Sanitaria Locale of Verona Verona</wicri:noRegion></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation wicri:level="1"><nlm:affiliation>State Agency of Medicines Tartu, Estonia.</nlm:affiliation><country xml:lang="fr">Estonie</country><wicri:regionArea>State Agency of Medicines Tartu</wicri:regionArea></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health and Child Care Harrare, Zimbabwe.</nlm:affiliation><country xml:lang="fr">Zimbabwe</country><wicri:regionArea>Ministry of Health and Child Care Harrare</wicri:regionArea></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Services, Ministry of Health Reykjavík, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>Department of Health Services, Ministry of Health Reykjavík</wicri:regionArea><wicri:noRegion>Ministry of Health Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation wicri:level="1"><nlm:affiliation>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana</wicri:regionArea><wicri:noRegion>University Medical Centre Ljubljana Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka, Bosnia and Herzegovina.</nlm:affiliation><country xml:lang="fr">Bosnie-Herzégovine</country><wicri:regionArea>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka</wicri:regionArea><wicri:noRegion>Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka</wicri:noRegion></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone, Botswana.</nlm:affiliation><country xml:lang="fr">Botswana</country><wicri:regionArea>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone</wicri:regionArea><wicri:noRegion>University of Botswana Gaborone</wicri:noRegion></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos</wicri:regionArea><wicri:noRegion>Lagos State University College of MedicineLagos</wicri:noRegion></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation wicri:level="1"><nlm:affiliation>National Centre for Pharmacoeconomics Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>National Centre for Pharmacoeconomics Dublin</wicri:regionArea></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation wicri:level="1"><nlm:affiliation>Hauptverband der Österreichischen Sozialversicherungsträger Wien, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Hauptverband der Österreichischen Sozialversicherungsträger Wien</wicri:regionArea></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation wicri:level="1"><nlm:affiliation>IRDES Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IRDES Paris</wicri:regionArea></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven</wicri:regionArea><wicri:noRegion>KU Leuven Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation wicri:level="1"><nlm:affiliation>Ministry of Health, Nelson Mandela Drive Gaborone, Botswana.</nlm:affiliation><country xml:lang="fr">Botswana</country><wicri:regionArea>Ministry of Health, Nelson Mandela Drive Gaborone</wicri:regionArea><wicri:noRegion>Nelson Mandela Drive Gaborone</wicri:noRegion></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation wicri:level="1"><nlm:affiliation>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth</wicri:regionArea><wicri:noRegion>Nelson Mandela Metropolitan University Port Elizabeth</wicri:noRegion></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation wicri:level="1"><nlm:affiliation>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm</wicri:regionArea><wicri:noRegion>Hälso-och Sjukvårdsförvaltningen Stockholm</wicri:noRegion></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Management, Comenius University Bratislava, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Faculty of Management, Comenius University Bratislava</wicri:regionArea><wicri:noRegion>Comenius University Bratislava</wicri:noRegion></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation wicri:level="1"><nlm:affiliation>HTA Consulting Cracow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>HTA Consulting Cracow</wicri:regionArea></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation wicri:level="1"><nlm:affiliation>School of Management and Business, King's College London London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Management and Business, King's College London London</wicri:regionArea><wicri:noRegion>King's College London London</wicri:noRegion></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H" last="Vural">Elif H. Vural</name><affiliation wicri:level="1"><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara</wicri:regionArea><wicri:noRegion>Ministry of Health Ankara</wicri:noRegion></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation wicri:level="1"><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Catalan Health Service - Servei Català de la Salut Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow</wicri:regionArea><wicri:noRegion>University of StrathclydeGlasgow</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in pharmacology</title><idno type="ISSN">1663-9812</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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