Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.
Identifieur interne : 001C18 ( PubMed/Corpus ); précédent : 001C17; suivant : 001C19Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.
Auteurs : Winnie De Bruijn ; Cristina Ibá Ez ; Pia Frisk ; Hanne Bak Pedersen ; Ali Alkan ; Patricia Vella Bonanno ; Ljiljana S. Brki I ; Anna Bucsics ; Guillaume Dedet ; Jaran Eriksen ; Joseph O. Fadare ; Jurij Fürst ; Gisselle Gallego ; Isabella P. God I ; Augusto A. Guerra Júnior ; Hakk Gürsöz ; Saira Jan ; Jan Jones ; Roberta Joppi ; Saim Kerman ; Ott Laius ; Newman Madzikwa ; Einar Magnússon ; Mojca Maticic ; Vanda Markovic-Pekovic ; Amos Massele ; Olayinka Ogunleye ; Aisling O'Leary ; Jutta Piessnegger ; Catherine Sermet ; Steven Simoens ; Celda Tiroyakgosi ; Ilse Truter ; Magnus Thyberg ; Kristina Tomekova ; Magdalena Wladysiuk ; Sotiris Vandoros ; Elif H. Vural ; Corinne Zara ; Brian GodmanSource :
- Frontiers in pharmacology [ 1663-9812 ] ; 2016.
Abstract
Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens.
DOI: 10.3389/fphar.2016.00197
PubMed: 27516740
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, Utrecht University Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation><nlm:affiliation>Public Health Services Committee, Stockholm County Council Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation><nlm:affiliation>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation><nlm:affiliation>Independent Pharmaceutical Consultant Mellieha, Malta.</nlm:affiliation></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S" last="Brki I">Ljiljana S. Brki I</name><affiliation><nlm:affiliation>Croatian Health Insurance Fund Zagreb, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation><nlm:affiliation>Department of Finance, University of Vienna Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation><nlm:affiliation>Ministry of Health Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O" last="Fadare">Joseph O. Fadare</name><affiliation><nlm:affiliation>Department of Pharmacology, Ekiti State University Ado-Ekiti, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation><nlm:affiliation>Health Insurance Institute Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation><nlm:affiliation>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P" last="God I">Isabella P. God I</name><affiliation><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A" last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation><nlm:affiliation>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation><nlm:affiliation>Scottish Medicines Consortium Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation><nlm:affiliation>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation><nlm:affiliation>State Agency of Medicines Tartu, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation><nlm:affiliation>Ministry of Health and Child Care Harrare, Zimbabwe.</nlm:affiliation></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation><nlm:affiliation>Department of Health Services, Ministry of Health Reykjavík, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation><nlm:affiliation>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka, Bosnia and Herzegovina.</nlm:affiliation></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone, Botswana.</nlm:affiliation></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation><nlm:affiliation>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation><nlm:affiliation>National Centre for Pharmacoeconomics Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation><nlm:affiliation>Hauptverband der Österreichischen Sozialversicherungsträger Wien, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation><nlm:affiliation>IRDES Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation><nlm:affiliation>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation><nlm:affiliation>Ministry of Health, Nelson Mandela Drive Gaborone, Botswana.</nlm:affiliation></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation><nlm:affiliation>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation><nlm:affiliation>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation><nlm:affiliation>Faculty of Management, Comenius University Bratislava, Slovakia.</nlm:affiliation></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation><nlm:affiliation>HTA Consulting Cracow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation><nlm:affiliation>School of Management and Business, King's College London London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H" last="Vural">Elif H. Vural</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27516740</idno><idno type="pmid">27516740</idno><idno type="doi">10.3389/fphar.2016.00197</idno><idno type="wicri:Area/PubMed/Corpus">001C18</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C18</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.</title><author><name sortKey="De Bruijn, Winnie" sort="De Bruijn, Winnie" uniqKey="De Bruijn W" first="Winnie" last="De Bruijn">Winnie De Bruijn</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, Utrecht University Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Iba Ez, Cristina" sort="Iba Ez, Cristina" uniqKey="Iba Ez C" first="Cristina" last="Ibá Ez">Cristina Ibá Ez</name><affiliation><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Frisk, Pia" sort="Frisk, Pia" uniqKey="Frisk P" first="Pia" last="Frisk">Pia Frisk</name><affiliation><nlm:affiliation>Public Health Services Committee, Stockholm County Council Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Bak Pedersen, Hanne" sort="Bak Pedersen, Hanne" uniqKey="Bak Pedersen H" first="Hanne" last="Bak Pedersen">Hanne Bak Pedersen</name><affiliation><nlm:affiliation>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Alkan, Ali" sort="Alkan, Ali" uniqKey="Alkan A" first="Ali" last="Alkan">Ali Alkan</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Vella Bonanno, Patricia" sort="Vella Bonanno, Patricia" uniqKey="Vella Bonanno P" first="Patricia" last="Vella Bonanno">Patricia Vella Bonanno</name><affiliation><nlm:affiliation>Independent Pharmaceutical Consultant Mellieha, Malta.</nlm:affiliation></affiliation></author><author><name sortKey="Brki I, Ljiljana S" sort="Brki I, Ljiljana S" uniqKey="Brki I L" first="Ljiljana S" last="Brki I">Ljiljana S. Brki I</name><affiliation><nlm:affiliation>Croatian Health Insurance Fund Zagreb, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Bucsics, Anna" sort="Bucsics, Anna" uniqKey="Bucsics A" first="Anna" last="Bucsics">Anna Bucsics</name><affiliation><nlm:affiliation>Department of Finance, University of Vienna Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Dedet, Guillaume" sort="Dedet, Guillaume" uniqKey="Dedet G" first="Guillaume" last="Dedet">Guillaume Dedet</name><affiliation><nlm:affiliation>Ministry of Health Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksen, Jaran" sort="Eriksen, Jaran" uniqKey="Eriksen J" first="Jaran" last="Eriksen">Jaran Eriksen</name><affiliation><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Fadare, Joseph O" sort="Fadare, Joseph O" uniqKey="Fadare J" first="Joseph O" last="Fadare">Joseph O. Fadare</name><affiliation><nlm:affiliation>Department of Pharmacology, Ekiti State University Ado-Ekiti, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="Furst, Jurij" sort="Furst, Jurij" uniqKey="Furst J" first="Jurij" last="Fürst">Jurij Fürst</name><affiliation><nlm:affiliation>Health Insurance Institute Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Gallego, Gisselle" sort="Gallego, Gisselle" uniqKey="Gallego G" first="Gisselle" last="Gallego">Gisselle Gallego</name><affiliation><nlm:affiliation>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="God I, Isabella P" sort="God I, Isabella P" uniqKey="God I I" first="Isabella P" last="God I">Isabella P. God I</name><affiliation><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Guerra Junior, Augusto A" sort="Guerra Junior, Augusto A" uniqKey="Guerra Junior A" first="Augusto A" last="Guerra Júnior">Augusto A. Guerra Júnior</name><affiliation><nlm:affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Gursoz, Hakk" sort="Gursoz, Hakk" uniqKey="Gursoz H" first="Hakk" last="Gürsöz">Hakk Gürsöz</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Jan, Saira" sort="Jan, Saira" uniqKey="Jan S" first="Saira" last="Jan">Saira Jan</name><affiliation><nlm:affiliation>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Jan" sort="Jones, Jan" uniqKey="Jones J" first="Jan" last="Jones">Jan Jones</name><affiliation><nlm:affiliation>Scottish Medicines Consortium Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Joppi, Roberta" sort="Joppi, Roberta" uniqKey="Joppi R" first="Roberta" last="Joppi">Roberta Joppi</name><affiliation><nlm:affiliation>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kerman, Saim" sort="Kerman, Saim" uniqKey="Kerman S" first="Saim" last="Kerman">Saim Kerman</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Laius, Ott" sort="Laius, Ott" uniqKey="Laius O" first="Ott" last="Laius">Ott Laius</name><affiliation><nlm:affiliation>State Agency of Medicines Tartu, Estonia.</nlm:affiliation></affiliation></author><author><name sortKey="Madzikwa, Newman" sort="Madzikwa, Newman" uniqKey="Madzikwa N" first="Newman" last="Madzikwa">Newman Madzikwa</name><affiliation><nlm:affiliation>Ministry of Health and Child Care Harrare, Zimbabwe.</nlm:affiliation></affiliation></author><author><name sortKey="Magnusson, Einar" sort="Magnusson, Einar" uniqKey="Magnusson E" first="Einar" last="Magnússon">Einar Magnússon</name><affiliation><nlm:affiliation>Department of Health Services, Ministry of Health Reykjavík, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Maticic, Mojca" sort="Maticic, Mojca" uniqKey="Maticic M" first="Mojca" last="Maticic">Mojca Maticic</name><affiliation><nlm:affiliation>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Markovic Pekovic, Vanda" sort="Markovic Pekovic, Vanda" uniqKey="Markovic Pekovic V" first="Vanda" last="Markovic-Pekovic">Vanda Markovic-Pekovic</name><affiliation><nlm:affiliation>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka, Bosnia and Herzegovina.</nlm:affiliation></affiliation></author><author><name sortKey="Massele, Amos" sort="Massele, Amos" uniqKey="Massele A" first="Amos" last="Massele">Amos Massele</name><affiliation><nlm:affiliation>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone, Botswana.</nlm:affiliation></affiliation></author><author><name sortKey="Ogunleye, Olayinka" sort="Ogunleye, Olayinka" uniqKey="Ogunleye O" first="Olayinka" last="Ogunleye">Olayinka Ogunleye</name><affiliation><nlm:affiliation>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos, Nigeria.</nlm:affiliation></affiliation></author><author><name sortKey="O Leary, Aisling" sort="O Leary, Aisling" uniqKey="O Leary A" first="Aisling" last="O'Leary">Aisling O'Leary</name><affiliation><nlm:affiliation>National Centre for Pharmacoeconomics Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Piessnegger, Jutta" sort="Piessnegger, Jutta" uniqKey="Piessnegger J" first="Jutta" last="Piessnegger">Jutta Piessnegger</name><affiliation><nlm:affiliation>Hauptverband der Österreichischen Sozialversicherungsträger Wien, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Sermet, Catherine" sort="Sermet, Catherine" uniqKey="Sermet C" first="Catherine" last="Sermet">Catherine Sermet</name><affiliation><nlm:affiliation>IRDES Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Simoens, Steven" sort="Simoens, Steven" uniqKey="Simoens S" first="Steven" last="Simoens">Steven Simoens</name><affiliation><nlm:affiliation>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Tiroyakgosi, Celda" sort="Tiroyakgosi, Celda" uniqKey="Tiroyakgosi C" first="Celda" last="Tiroyakgosi">Celda Tiroyakgosi</name><affiliation><nlm:affiliation>Ministry of Health, Nelson Mandela Drive Gaborone, Botswana.</nlm:affiliation></affiliation></author><author><name sortKey="Truter, Ilse" sort="Truter, Ilse" uniqKey="Truter I" first="Ilse" last="Truter">Ilse Truter</name><affiliation><nlm:affiliation>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Thyberg, Magnus" sort="Thyberg, Magnus" uniqKey="Thyberg M" first="Magnus" last="Thyberg">Magnus Thyberg</name><affiliation><nlm:affiliation>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tomekova, Kristina" sort="Tomekova, Kristina" uniqKey="Tomekova K" first="Kristina" last="Tomekova">Kristina Tomekova</name><affiliation><nlm:affiliation>Faculty of Management, Comenius University Bratislava, Slovakia.</nlm:affiliation></affiliation></author><author><name sortKey="Wladysiuk, Magdalena" sort="Wladysiuk, Magdalena" uniqKey="Wladysiuk M" first="Magdalena" last="Wladysiuk">Magdalena Wladysiuk</name><affiliation><nlm:affiliation>HTA Consulting Cracow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Vandoros, Sotiris" sort="Vandoros, Sotiris" uniqKey="Vandoros S" first="Sotiris" last="Vandoros">Sotiris Vandoros</name><affiliation><nlm:affiliation>School of Management and Business, King's College London London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vural, Elif H" sort="Vural, Elif H" uniqKey="Vural E" first="Elif H" last="Vural">Elif H. Vural</name><affiliation><nlm:affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</nlm:affiliation></affiliation></author><author><name sortKey="Zara, Corinne" sort="Zara, Corinne" uniqKey="Zara C" first="Corinne" last="Zara">Corinne Zara</name><affiliation><nlm:affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Godman, Brian" sort="Godman, Brian" uniqKey="Godman B" first="Brian" last="Godman">Brian Godman</name><affiliation><nlm:affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of StrathclydeGlasgow, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in pharmacology</title><idno type="ISSN">1663-9812</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27516740</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>08</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1663-9812</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Frontiers in pharmacology</Title><ISOAbbreviation>Front Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Introduction and Utilization of High Priced HCV Medicines across Europe; Implications for the Future.</ArticleTitle><Pagination><MedlinePgn>197</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fphar.2016.00197</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Assess the uptake of BCV and TVR across Europe from a health authority perspective to offer future guidance on dealing with new high cost medicines.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Cross-sectional descriptive study of medicines to treat HCV (pegIFN, ribavirin, BCV and TVR) among European countries from 2008 to 2013. Utilization measured in defined daily doses (DDDs)/1000 patients/quarter (DIQs) and expenditure in Euros/DDD. Health authority activities to influence treatments categorized using the 4E methodology (Education, Engineering, Economics and Enforcement).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Similar uptake of BCV and TVR among European countries and regions, ranging from 0.5 DIQ in Denmark, Netherlands and Slovenia to 1.5 DIQ in Tayside and Catalonia in 2013. However, different utilization of the new PIs vs. ribavirin indicates differences in dual vs. triple therapy, which is down to factors including physician preference and genotypes. Reimbursed prices for BCV and TVR were comparable across countries.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">There was reasonable consistency in the utilization of BCV and TVR among European countries in comparison with other high priced medicines. This may reflect the social demand to limit the transmission of HCV. However, the situation is changing with new curative medicines for HCV genotype 1 (GT1) with potentially an appreciable budget impact. These concerns have resulted in different prices across countries, with their impact on budgets and patient outcomes monitored in the future to provide additional guidance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Bruijn</LastName><ForeName>Winnie</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Utrecht University Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ibáñez</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frisk</LastName><ForeName>Pia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Public Health Services Committee, Stockholm County Council Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bak Pedersen</LastName><ForeName>Hanne</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Health Technologies and Pharmaceuticals, Division of Health Systems and Public Health, WHO Regional Office for Europe Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alkan</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vella Bonanno</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Independent Pharmaceutical Consultant Mellieha, Malta.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brkičić</LastName><ForeName>Ljiljana S</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>Croatian Health Insurance Fund Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bucsics</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Finance, University of Vienna Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dedet</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Ministry of Health Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksen</LastName><ForeName>Jaran</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fadare</LastName><ForeName>Joseph O</ForeName><Initials>JO</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Ekiti State University Ado-Ekiti, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fürst</LastName><ForeName>Jurij</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Health Insurance Institute Ljubljana, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallego</LastName><ForeName>Gisselle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>School of Medicine, The University of Notre Dame AustraliaDarlinghurst, NSW, Australia; Department of Pharmacology and Clinical Neuroscience, Umea UniversityUmea, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godói</LastName><ForeName>Isabella P</ForeName><Initials>IP</Initials><AffiliationInfo><Affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guerra Júnior</LastName><ForeName>Augusto A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>School of Pharmacy, Graduate Program in Medicines and Pharmaceutical Assistance, Federal University of Minas GeraisBelo Horizonte, Brazil; Department of Social Pharmacy, SUS Collaborating Centre - Health Technology Assessment and Excellence in Health, College of Pharmacy, Federal University of Minas GeraisBelo Horizonte, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gürsöz</LastName><ForeName>Hakkı</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jan</LastName><ForeName>Saira</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Clinical Pharmacy, Rutgers State University of New JerseyPiscataway, NJ, USA; Horizon Blue Cross Blue Shield of New JerseyNewark, NJ, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Jan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Scottish Medicines Consortium Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joppi</LastName><ForeName>Roberta</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Pharmaceutical Drug Department, Azienda Sanitaria Locale of Verona Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerman</LastName><ForeName>Saim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laius</LastName><ForeName>Ott</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>State Agency of Medicines Tartu, Estonia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madzikwa</LastName><ForeName>Newman</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Ministry of Health and Child Care Harrare, Zimbabwe.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Magnússon</LastName><ForeName>Einar</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Health Services, Ministry of Health Reykjavík, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maticic</LastName><ForeName>Mojca</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinic for Infectious Diseases and Febrile Illnesses, University Medical Centre Ljubljana Ljubljana, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Markovic-Pekovic</LastName><ForeName>Vanda</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, University of Banja LukaBanja Luka, Bosnia and Herzegovina; Ministry of Health and Social WelfareBanja Luka, Bosnia and Herzegovina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Massele</LastName><ForeName>Amos</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Pharmacology, School of Medicine, University of Botswana Gaborone, Botswana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogunleye</LastName><ForeName>Olayinka</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Clinical Pharmacology Unit, Department of Medicine, Lagos State University Teaching HospitalLagos, Nigeria; Department of Pharmacology and Therapeutics, Lagos State University College of MedicineLagos, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Leary</LastName><ForeName>Aisling</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>National Centre for Pharmacoeconomics Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piessnegger</LastName><ForeName>Jutta</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hauptverband der Österreichischen Sozialversicherungsträger Wien, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sermet</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>IRDES Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simoens</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical and Pharmacological Sciences, KU Leuven Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tiroyakgosi</LastName><ForeName>Celda</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Ministry of Health, Nelson Mandela Drive Gaborone, Botswana.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Truter</LastName><ForeName>Ilse</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Drug Utilisation Research Unit, Faculty of Health Sciences, Nelson Mandela Metropolitan University Port Elizabeth, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thyberg</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Stockholms Läns Landsting, Hälso-och Sjukvårdsförvaltningen Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomekova</LastName><ForeName>Kristina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Management, Comenius University Bratislava, Slovakia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wladysiuk</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>HTA Consulting Cracow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vandoros</LastName><ForeName>Sotiris</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Management and Business, King's College London London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vural</LastName><ForeName>Elif H</ForeName><Initials>EH</Initials><AffiliationInfo><Affiliation>Turkish Medicines and Medical Devices Agency, Ministry of Health Ankara, Turkey.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zara</LastName><ForeName>Corinne</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Catalan Health Service - Servei Català de la Salut Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godman</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital HuddingeStockholm, Sweden; Strathclyde 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Version="1">25086286</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hepatology. 2013 Apr;57(4):1333-42</RefSource><PMID Version="1">23172780</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4964878</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Hepatitis C</Keyword><Keyword MajorTopicYN="N">boceprevir</Keyword><Keyword MajorTopicYN="N">cross national drug utilization study</Keyword><Keyword MajorTopicYN="N">demand-side measures</Keyword><Keyword MajorTopicYN="N">introduction new medicines</Keyword><Keyword MajorTopicYN="N">sofosbuvir</Keyword><Keyword MajorTopicYN="N">telaprevir</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>04</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>21</Day></PubMedPubDate><PubMedPubDate 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