Identification of early breast cancer patient cohorts who may benefit from lapatinib therapy.
Identifieur interne : 003075 ( Ncbi/Merge ); précédent : 003074; suivant : 003076Identification of early breast cancer patient cohorts who may benefit from lapatinib therapy.
Auteurs : Kathrin Strasser-Weippl [Autriche] ; Nora Horick [États-Unis] ; Ian E. Smith [Royaume-Uni] ; Joyce O'Shaughnessy [États-Unis] ; Bent Ejlertsen [Danemark] ; Frances Boyle [Australie] ; Aman U. Buzdar [États-Unis] ; Pierre Fumoleau [France] ; William Gradishar [États-Unis] ; Miguel Martin [Espagne] ; Beverly Moy [États-Unis] ; Martine Piccart-Gebhart [Belgique] ; Kathleen I. Pritchard [Canada] ; Deborah Lindquist [États-Unis] ; Erica Rappold [États-Unis] ; Dianne M. Finkelstein [États-Unis] ; Paul E. Goss [États-Unis]Source :
- European journal of cancer (Oxford, England : 1990) [ 1879-0852 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antinéoplasiques (effets indésirables), Antinéoplasiques (usage thérapeutique), Estimation de Kaplan-Meier, Facteurs temps, Femelle, Humains, Inhibiteurs de protéines kinases (effets indésirables), Inhibiteurs de protéines kinases (usage thérapeutique), Modèles de hasards proportionnels, Médecine individualisée, Quinazolines (effets indésirables), Quinazolines (usage thérapeutique), Récepteur ErbB-2 (antagonistes et inhibiteurs), Récepteur ErbB-2 (génétique), Récepteur ErbB-2 (métabolisme), Récidive tumorale locale, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Sélection de patients, Technique FISH, Traitement médicamenteux adjuvant, Transduction du signal (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (enzymologie), Tumeurs du sein (génétique), Tumeurs du sein (mortalité), Tumeurs du sein (traitement médicamenteux).
- MESH :
- anatomopathologie : Tumeurs du sein.
- antagonistes et inhibiteurs : Récepteur ErbB-2.
- effets indésirables : Antinéoplasiques, Inhibiteurs de protéines kinases, Quinazolines.
- enzymologie : Tumeurs du sein.
- génétique : Récepteur ErbB-2, Tumeurs du sein.
- mortalité : Tumeurs du sein.
- métabolisme : Récepteur ErbB-2.
- traitement médicamenteux : Tumeurs du sein.
- usage thérapeutique : Antinéoplasiques, Inhibiteurs de protéines kinases, Quinazolines.
- Adulte, Adulte d'âge moyen, Estimation de Kaplan-Meier, Facteurs temps, Femelle, Humains, Modèles de hasards proportionnels, Médecine individualisée, Récidive tumorale locale, Résultat thérapeutique, Stade de la tumeur, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Sélection de patients, Technique FISH, Traitement médicamenteux adjuvant, Transduction du signal.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents (adverse effects), Antineoplastic Agents (therapeutic use), Breast Neoplasms (drug therapy), Breast Neoplasms (enzymology), Breast Neoplasms (genetics), Breast Neoplasms (mortality), Breast Neoplasms (pathology), Chemotherapy, Adjuvant, Disease-Free Survival, Female, Humans, In Situ Hybridization, Fluorescence, Kaplan-Meier Estimate, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Patient Selection, Precision Medicine, Proportional Hazards Models, Protein Kinase Inhibitors (adverse effects), Protein Kinase Inhibitors (therapeutic use), Quinazolines (adverse effects), Quinazolines (therapeutic use), Receptor, ErbB-2 (antagonists & inhibitors), Receptor, ErbB-2 (genetics), Receptor, ErbB-2 (metabolism), Signal Transduction (drug effects), Time Factors, Treatment Outcome.
- MESH :
- chemical , adverse effects : Antineoplastic Agents, Protein Kinase Inhibitors, Quinazolines.
- chemical , antagonists & inhibitors : Receptor, ErbB-2.
- chemical , genetics : Receptor, ErbB-2.
- chemical , metabolism : Receptor, ErbB-2.
- chemical , therapeutic use : Antineoplastic Agents, Protein Kinase Inhibitors, Quinazolines.
- drug effects : Signal Transduction.
- drug therapy : Breast Neoplasms.
- enzymology : Breast Neoplasms.
- genetics : Breast Neoplasms.
- mortality : Breast Neoplasms.
- pathology : Breast Neoplasms.
- Adult, Aged, Aged, 80 and over, Chemotherapy, Adjuvant, Disease-Free Survival, Female, Humans, In Situ Hybridization, Fluorescence, Kaplan-Meier Estimate, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Patient Selection, Precision Medicine, Proportional Hazards Models, Time Factors, Treatment Outcome.
Abstract
In resource-constrained environments many patients with human epidermal growth factor receptor 2 (HER2)+ early breast cancer are currently not offered adjuvant anti-HER2 therapy. For patients who might be able to receive the tyrosine kinase inhibitor (TKI) lapatinib (e.g. after patent expiration), it is important to identify subgroups of patients for whom anti-HER2 TKI therapy could be beneficial. To do this, we used data from 2489 patients with centrally confirmed HER2+ disease enrolled in the adjuvant Tykerb Evaluation After Chemotherapy (TEACH) trial, investigating the effect of lapatinib in patients with HER2+ early breast cancer not treated with trastuzumab. We performed subgroup analyses and number-needed-to-treat (NNT) calculations using patient and tumour associated predictors. Hormone receptor negative (HR-) patients on lapatinib had a significantly prolonged disease-free survival (DFS) compared to HR- patients on placebo (hazard ratio 0.64, P=0.003). For patients with HR- disease, starting treatment with lapatinib ≤1 year from diagnosis improved DFS by 12.1% [2.1-22.1] at 2 years and 15.7% [4.1-27.2] at 5 years. Depending on lymph node status and time since diagnosis the NNT for recurrence (at 5 years) was between 5.9 (node positive patients <1 year from diagnosis) and 15.9. These numbers are in range with numbers reported for up-front adjuvant trastuzumab for HR unselected patients (e.g. 15.6 for DFS at 4 years in HERA). In a subgroup analysis of the adjuvant TEACH trial, we show that anti-HER2 monotherapy with a TKI is beneficial as adjuvant therapy in a subgroup of patients. NNT in HER2+ HR- patients are in range with those reported from up-front adjuvant trastuzumab trials.
DOI: 10.1016/j.ejca.2015.12.024
PubMed: 26829011
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pubmed:26829011Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of early breast cancer patient cohorts who may benefit from lapatinib therapy.</title>
<author><name sortKey="Strasser Weippl, Kathrin" sort="Strasser Weippl, Kathrin" uniqKey="Strasser Weippl K" first="Kathrin" last="Strasser-Weippl">Kathrin Strasser-Weippl</name>
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<author><name sortKey="Horick, Nora" sort="Horick, Nora" uniqKey="Horick N" first="Nora" last="Horick">Nora Horick</name>
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<author><name sortKey="Smith, Ian E" sort="Smith, Ian E" uniqKey="Smith I" first="Ian E" last="Smith">Ian E. Smith</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="O Shaughnessy, Joyce" sort="O Shaughnessy, Joyce" uniqKey="O Shaughnessy J" first="Joyce" last="O'Shaughnessy">Joyce O'Shaughnessy</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Rigshospitalet, DBCG Secretariat, Copenhagen, Denmark. Electronic address: ejlertsen@dadlnet.dk.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Rigshospitalet, DBCG Secretariat, Copenhagen</wicri:regionArea>
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<author><name sortKey="Boyle, Frances" sort="Boyle, Frances" uniqKey="Boyle F" first="Frances" last="Boyle">Frances Boyle</name>
<affiliation wicri:level="1"><nlm:affiliation>Mater Hospital, North Sydney, NSW, Australia. Electronic address: franb@bigpond.net.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<author><name sortKey="Buzdar, Aman U" sort="Buzdar, Aman U" uniqKey="Buzdar A" first="Aman U" last="Buzdar">Aman U. Buzdar</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea>
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<author><name sortKey="Fumoleau, Pierre" sort="Fumoleau, Pierre" uniqKey="Fumoleau P" first="Pierre" last="Fumoleau">Pierre Fumoleau</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Centre GF Leclerc, Dijon</wicri:regionArea>
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<author><name sortKey="Gradishar, William" sort="Gradishar, William" uniqKey="Gradishar W" first="William" last="Gradishar">William Gradishar</name>
<affiliation wicri:level="2"><nlm:affiliation>Northwestern University, Chicago, IL, USA. Electronic address: WGradishar@nmff.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Northwestern University, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
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<author><name sortKey="Martin, Miguel" sort="Martin, Miguel" uniqKey="Martin M" first="Miguel" last="Martin">Miguel Martin</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Universitario Gregorio Marañón, Universidad Complutense, Madrid</wicri:regionArea>
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<author><name sortKey="Moy, Beverly" sort="Moy, Beverly" uniqKey="Moy B" first="Beverly" last="Moy">Beverly Moy</name>
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<author><name sortKey="Piccart Gebhart, Martine" sort="Piccart Gebhart, Martine" uniqKey="Piccart Gebhart M" first="Martine" last="Piccart-Gebhart">Martine Piccart-Gebhart</name>
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<country xml:lang="fr">Belgique</country>
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<front><div type="abstract" xml:lang="en">In resource-constrained environments many patients with human epidermal growth factor receptor 2 (HER2)+ early breast cancer are currently not offered adjuvant anti-HER2 therapy. For patients who might be able to receive the tyrosine kinase inhibitor (TKI) lapatinib (e.g. after patent expiration), it is important to identify subgroups of patients for whom anti-HER2 TKI therapy could be beneficial. To do this, we used data from 2489 patients with centrally confirmed HER2+ disease enrolled in the adjuvant Tykerb Evaluation After Chemotherapy (TEACH) trial, investigating the effect of lapatinib in patients with HER2+ early breast cancer not treated with trastuzumab. We performed subgroup analyses and number-needed-to-treat (NNT) calculations using patient and tumour associated predictors. Hormone receptor negative (HR-) patients on lapatinib had a significantly prolonged disease-free survival (DFS) compared to HR- patients on placebo (hazard ratio 0.64, P=0.003). For patients with HR- disease, starting treatment with lapatinib ≤1 year from diagnosis improved DFS by 12.1% [2.1-22.1] at 2 years and 15.7% [4.1-27.2] at 5 years. Depending on lymph node status and time since diagnosis the NNT for recurrence (at 5 years) was between 5.9 (node positive patients <1 year from diagnosis) and 15.9. These numbers are in range with numbers reported for up-front adjuvant trastuzumab for HR unselected patients (e.g. 15.6 for DFS at 4 years in HERA). In a subgroup analysis of the adjuvant TEACH trial, we show that anti-HER2 monotherapy with a TKI is beneficial as adjuvant therapy in a subgroup of patients. NNT in HER2+ HR- patients are in range with those reported from up-front adjuvant trastuzumab trials.</div>
</front>
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<DateCreated><Year>2016</Year>
<Month>02</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>07</Month>
<Day>12</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>02</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0852</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>56</Volume>
<PubDate><Year>2016</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>European journal of cancer (Oxford, England : 1990)</Title>
<ISOAbbreviation>Eur. J. Cancer</ISOAbbreviation>
</Journal>
<ArticleTitle>Identification of early breast cancer patient cohorts who may benefit from lapatinib therapy.</ArticleTitle>
<Pagination><MedlinePgn>85-92</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ejca.2015.12.024</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0959-8049(15)01180-6</ELocationID>
<Abstract><AbstractText>In resource-constrained environments many patients with human epidermal growth factor receptor 2 (HER2)+ early breast cancer are currently not offered adjuvant anti-HER2 therapy. For patients who might be able to receive the tyrosine kinase inhibitor (TKI) lapatinib (e.g. after patent expiration), it is important to identify subgroups of patients for whom anti-HER2 TKI therapy could be beneficial. To do this, we used data from 2489 patients with centrally confirmed HER2+ disease enrolled in the adjuvant Tykerb Evaluation After Chemotherapy (TEACH) trial, investigating the effect of lapatinib in patients with HER2+ early breast cancer not treated with trastuzumab. We performed subgroup analyses and number-needed-to-treat (NNT) calculations using patient and tumour associated predictors. Hormone receptor negative (HR-) patients on lapatinib had a significantly prolonged disease-free survival (DFS) compared to HR- patients on placebo (hazard ratio 0.64, P=0.003). For patients with HR- disease, starting treatment with lapatinib ≤1 year from diagnosis improved DFS by 12.1% [2.1-22.1] at 2 years and 15.7% [4.1-27.2] at 5 years. Depending on lymph node status and time since diagnosis the NNT for recurrence (at 5 years) was between 5.9 (node positive patients <1 year from diagnosis) and 15.9. These numbers are in range with numbers reported for up-front adjuvant trastuzumab for HR unselected patients (e.g. 15.6 for DFS at 4 years in HERA). In a subgroup analysis of the adjuvant TEACH trial, we show that anti-HER2 monotherapy with a TKI is beneficial as adjuvant therapy in a subgroup of patients. NNT in HER2+ HR- patients are in range with those reported from up-front adjuvant trastuzumab trials.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Strasser-Weippl</LastName>
<ForeName>Kathrin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Center for Oncology and Hematology, Wilhelminen Hospital, Vienna, Austria. Electronic address: kathrin.strasserweippl@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Horick</LastName>
<ForeName>Nora</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Massachusetts General Hospital Biostatistics Center, Boston, MA, USA. Electronic address: nhorick@partners.org.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Ian E</ForeName>
<Initials>IE</Initials>
<AffiliationInfo><Affiliation>Royal Marsden Hospital, London, UK. Electronic address: ian.smith@rmh.nhs.uk.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Joyce</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Baylor Sammons Cancer Center, Texas Oncology, US Oncology, Dallas, TX, USA. Electronic address: Joyce.OShaughnessy@usoncology.com.</Affiliation>
</AffiliationInfo>
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<ForeName>Bent</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Rigshospitalet, DBCG Secretariat, Copenhagen, Denmark. Electronic address: ejlertsen@dadlnet.dk.</Affiliation>
</AffiliationInfo>
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<ForeName>Frances</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Mater Hospital, North Sydney, NSW, Australia. Electronic address: franb@bigpond.net.au.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Buzdar</LastName>
<ForeName>Aman U</ForeName>
<Initials>AU</Initials>
<AffiliationInfo><Affiliation>University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: abuzdar@mdanderson.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fumoleau</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre GF Leclerc, Dijon, France. Electronic address: pfumoleau@cgfl.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gradishar</LastName>
<ForeName>William</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Northwestern University, Chicago, IL, USA. Electronic address: WGradishar@nmff.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martin</LastName>
<ForeName>Miguel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Hospital Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain. Electronic address: mmartin@geicam.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Moy</LastName>
<ForeName>Beverly</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Massachusetts General Hospital, Boston, MA, USA. Electronic address: bmoy@partners.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piccart-Gebhart</LastName>
<ForeName>Martine</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium. Electronic address: martine.piccart@bordet.be.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pritchard</LastName>
<ForeName>Kathleen I</ForeName>
<Initials>KI</Initials>
<AffiliationInfo><Affiliation>Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada. Electronic address: kathy.pritchard@sunnybrook.ca.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lindquist</LastName>
<ForeName>Deborah</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Arizona Oncology, US Oncology, Sedona, AZ, USA. Electronic address: deborah.lindquist@usoncology.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rappold</LastName>
<ForeName>Erica</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>GlaxoSmithKline, Collegeville, PA, USA. Electronic address: mprcer@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Finkelstein</LastName>
<ForeName>Dianne M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>Massachusetts General Hospital Biostatistics Center, Boston, MA, USA. Electronic address: dfinkelstein@partners.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goss</LastName>
<ForeName>Paul E</ForeName>
<Initials>PE</Initials>
<AffiliationInfo><Affiliation>Massachusetts General Hospital, Boston, MA, USA. Electronic address: pgoss@partners.org.</Affiliation>
</AffiliationInfo>
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<Month>01</Month>
<Day>30</Day>
</ArticleDate>
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<Keyword MajorTopicYN="N">Early breast cancer</Keyword>
<Keyword MajorTopicYN="N">Hormone receptor</Keyword>
<Keyword MajorTopicYN="N">Lapatinib</Keyword>
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<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
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<PubMedPubDate PubStatus="medline"><Year>2016</Year>
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<ArticleId IdType="doi">10.1016/j.ejca.2015.12.024</ArticleId>
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<li>Communauté de Madrid</li>
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<li>Illinois</li>
<li>Massachusetts</li>
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<country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Fumoleau, Pierre" sort="Fumoleau, Pierre" uniqKey="Fumoleau P" first="Pierre" last="Fumoleau">Pierre Fumoleau</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Pritchard, Kathleen I" sort="Pritchard, Kathleen I" uniqKey="Pritchard K" first="Kathleen I" last="Pritchard">Kathleen I. Pritchard</name>
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