AustralieFrV1, Ncbi, Merge, bibRecord, 002E83

The myofibroblast, a key cell in normal and pathological tissue repair.

Identifieur interne : 002E83 ( Ncbi/Merge ); précédent : 002E82; suivant : 002E84

The myofibroblast, a key cell in normal and pathological tissue repair.

Auteurs : Ian A. Darby [Australie] ; Noraina Zakuan [Australie] ; Fabrice Billet [France] ; Alexis Desmoulière [France]

Source :

Cellular and molecular life sciences : CMLS [ 1420-9071 ] ; 2016.

RBID : pubmed:26681260

Descripteurs français

KwdFr :
- Animaux, Cicatrice (anatomopathologie), Cicatrice (métabolisme), Cicatrisation de plaie, Humains, Myofibroblastes (anatomopathologie), Myofibroblastes (cytologie), Myofibroblastes (métabolisme), Tumeurs (anatomopathologie), Tumeurs (métabolisme).
MESH :
- anatomopathologie : Cicatrice, Myofibroblastes, Tumeurs.
- cytologie : Myofibroblastes.
- métabolisme : Cicatrice, Myofibroblastes, Tumeurs.
- Animaux, Cicatrisation de plaie, Humains.

English descriptors

KwdEn :
- Animals, Cicatrix (metabolism), Cicatrix (pathology), Humans, Myofibroblasts (cytology), Myofibroblasts (metabolism), Myofibroblasts (pathology), Neoplasms (metabolism), Neoplasms (pathology), Wound Healing.
MESH :
- cytology : Myofibroblasts.
- metabolism : Cicatrix, Myofibroblasts, Neoplasms.
- pathology : Cicatrix, Myofibroblasts, Neoplasms.
- Animals, Humans, Wound Healing.

Abstract

Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particularly in the skin where they were first described. During normal tissue repair, they appear transiently and are then lost via apoptosis. However, the chronic presence and continued activity of myofibroblasts characterize many fibrotic pathologies, in the skin and internal organs including the liver, kidney and lung. More recently, it has become clear that myofibroblasts also play a role in many types of cancer as stromal or cancer-associated myofibroblast. The fact that myofibroblasts are now known to be key players in many pathologies makes understanding their functions, origin and the regulation of their differentiation important to enable them to be regulated in normal physiology and targeted in fibrosis, scarring and cancer.

DOI: 10.1007/s00018-015-2110-0
PubMed: 26681260

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002152
to stream PubMed, to step Curation: 002126
to stream PubMed, to step Checkpoint: 002126

Links to Exploration step

pubmed:26681260

Le document en format XML

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<term>Myofibroblasts (metabolism)</term>
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<front><div type="abstract" xml:lang="en">Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particularly in the skin where they were first described. During normal tissue repair, they appear transiently and are then lost via apoptosis. However, the chronic presence and continued activity of myofibroblasts characterize many fibrotic pathologies, in the skin and internal organs including the liver, kidney and lung. More recently, it has become clear that myofibroblasts also play a role in many types of cancer as stromal or cancer-associated myofibroblast. The fact that myofibroblasts are now known to be key players in many pathologies makes understanding their functions, origin and the regulation of their differentiation important to enable them to be regulated in normal physiology and targeted in fibrosis, scarring and cancer.</div>
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Serveur d'exploration sur les relations entre la France et l'Australie

The myofibroblast, a key cell in normal and pathological tissue repair.

The myofibroblast, a key cell in normal and pathological tissue repair.

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