Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery
Identifieur interne : 002192 ( Ncbi/Merge ); précédent : 002191; suivant : 002193Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery
Auteurs : Innocent J. Macha ; Sophie Cazalbou ; Besim Ben-Nissan ; Kate L. Harvey ; Bruce MilthorpeSource :
- Marine Drugs [ 1660-3397 ] ; 2015.
Descripteurs français
- KwdFr :
- Antibactériens (administration et posologie), Céramiques (), Gentamicine (administration et posologie), Hydroxyapatites (), Microscopie électronique à balayage, Phosphates de calcium (), Phosphates de calcium (administration et posologie), Polymères (), Polymères (administration et posologie), Résistance à la traction, Staphylococcus aureus (), Systèmes de délivrance de médicaments (), Tests de sensibilité microbienne.
- MESH :
- administration et posologie : Antibactériens, Gentamicine, Phosphates de calcium, Polymères.
- Céramiques, Hydroxyapatites, Microscopie électronique à balayage, Phosphates de calcium, Polymères, Résistance à la traction, Staphylococcus aureus, Systèmes de délivrance de médicaments, Tests de sensibilité microbienne.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (administration & dosage), Calcium Phosphates (administration & dosage), Calcium Phosphates (chemistry), Ceramics (chemistry), Drug Delivery Systems (methods), Gentamicins (administration & dosage), Hydroxyapatites (chemistry), Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Polymers (administration & dosage), Polymers (chemistry), Staphylococcus aureus (drug effects), Tensile Strength.
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Calcium Phosphates, Gentamicins, Polymers.
- chemical , chemistry : Calcium Phosphates, Hydroxyapatites, Polymers.
- chemistry : Ceramics.
- drug effects : Staphylococcus aureus.
- methods : Drug Delivery Systems.
- Microbial Sensitivity Tests, Microscopy, Electron, Scanning, Tensile Strength.
Abstract
Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against
Url:
DOI: 10.3390/md13010666
PubMed: 25608725
PubMed Central: 4306957
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PMC:4306957Le document en format XML
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Macha</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation><nlm:aff id="af2-marinedrugs-13-00666">CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></nlm:aff></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L." last="Harvey">Kate L. 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Macha</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation><nlm:aff id="af2-marinedrugs-13-00666">CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></nlm:aff></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L." last="Harvey">Kate L. Harvey</name><affiliation><nlm:aff id="af3-marinedrugs-13-00666">The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Kate.l.harvey@student.uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation><nlm:aff id="af4-marinedrugs-13-00666">Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Bruce.Milthorpe@uts.edu.au</email></nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (administration & dosage)</term><term>Calcium Phosphates (administration & dosage)</term><term>Calcium Phosphates (chemistry)</term><term>Ceramics (chemistry)</term><term>Drug Delivery Systems (methods)</term><term>Gentamicins (administration & dosage)</term><term>Hydroxyapatites (chemistry)</term><term>Microbial Sensitivity Tests</term><term>Microscopy, Electron, Scanning</term><term>Polymers (administration & dosage)</term><term>Polymers (chemistry)</term><term>Staphylococcus aureus (drug effects)</term><term>Tensile Strength</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antibactériens (administration et posologie)</term><term>Céramiques ()</term><term>Gentamicine (administration et posologie)</term><term>Hydroxyapatites ()</term><term>Microscopie électronique à balayage</term><term>Phosphates de calcium ()</term><term>Phosphates de calcium (administration et posologie)</term><term>Polymères ()</term><term>Polymères (administration et posologie)</term><term>Résistance à la traction</term><term>Staphylococcus aureus ()</term><term>Systèmes de délivrance de médicaments ()</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Calcium Phosphates</term><term>Gentamicins</term><term>Polymers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Phosphates</term><term>Hydroxyapatites</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Gentamicine</term><term>Phosphates de calcium</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Ceramics</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Delivery Systems</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term><term>Microscopy, Electron, Scanning</term><term>Tensile Strength</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Céramiques</term><term>Hydroxyapatites</term><term>Microscopie électronique à balayage</term><term>Phosphates de calcium</term><term>Polymères</term><term>Résistance à la traction</term><term>Staphylococcus aureus</term><term>Systèmes de délivrance de médicaments</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca<sup>2+</sup> for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against <italic>Staphylococcus aureus</italic> (<italic>S. aureus</italic>) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by <italic>S. aureus</italic> in surgery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ginebra, M P" uniqKey="Ginebra M">M.P. Ginebra</name></author><author><name sortKey="Traykova, T" uniqKey="Traykova T">T. Traykova</name></author><author><name sortKey="Planell, J A" uniqKey="Planell J">J.A. Planell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Habibe, A F" uniqKey="Habibe A">A.F. Habibe</name></author><author><name sortKey="Maeda, L D" uniqKey="Maeda L">L.D. 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Newton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="25608725"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery</title><author><name sortKey="Macha, Innocent J" sort="Macha, Innocent J" uniqKey="Macha I" first="Innocent J." last="Macha">Innocent J. Macha</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation><nlm:aff id="af2-marinedrugs-13-00666">CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></nlm:aff></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L." last="Harvey">Kate L. Harvey</name><affiliation><nlm:aff id="af3-marinedrugs-13-00666">The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Kate.l.harvey@student.uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation><nlm:aff id="af4-marinedrugs-13-00666">Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Bruce.Milthorpe@uts.edu.au</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25608725</idno><idno type="pmc">4306957</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306957</idno><idno type="RBID">PMC:4306957</idno><idno type="doi">10.3390/md13010666</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002744</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002744</idno><idno type="wicri:Area/Pmc/Curation">002594</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002594</idno><idno type="wicri:Area/Pmc/Checkpoint">000E70</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery</title><author><name sortKey="Macha, Innocent J" sort="Macha, Innocent J" uniqKey="Macha I" first="Innocent J." last="Macha">Innocent J. Macha</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation><nlm:aff id="af2-marinedrugs-13-00666">CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></nlm:aff></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L." last="Harvey">Kate L. Harvey</name><affiliation><nlm:aff id="af3-marinedrugs-13-00666">The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Kate.l.harvey@student.uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation><nlm:aff id="af4-marinedrugs-13-00666">Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Bruce.Milthorpe@uts.edu.au</email></nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca<sup>2+</sup> for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against <italic>Staphylococcus aureus</italic> (<italic>S. aureus</italic>) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by <italic>S. aureus</italic> in surgery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ginebra, M P" uniqKey="Ginebra M">M.P. Ginebra</name></author><author><name sortKey="Traykova, T" uniqKey="Traykova T">T. Traykova</name></author><author><name sortKey="Planell, J A" uniqKey="Planell J">J.A. Planell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Habibe, A F" uniqKey="Habibe A">A.F. Habibe</name></author><author><name sortKey="Maeda, L D" uniqKey="Maeda L">L.D. Maeda</name></author><author><name sortKey="Souza, R C" uniqKey="Souza R">R.C. Souza</name></author><author><name sortKey="Barboza, M J R" uniqKey="Barboza M">M.J.R. Barboza</name></author><author><name sortKey="Daguano, J K M F" uniqKey="Daguano J">J.K.M.F. Daguano</name></author><author><name sortKey="Rogero, S O" uniqKey="Rogero S">S.O. Rogero</name></author><author><name sortKey="Santos, C" uniqKey="Santos C">C. Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sivakumar, M" uniqKey="Sivakumar M">M. Sivakumar</name></author><author><name sortKey="Rao, K P" uniqKey="Rao K">K.P. Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Nissan, B" uniqKey="Ben Nissan B">B. Ben-Nissan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baro, M" uniqKey="Baro M">M. Baro</name></author><author><name sortKey="Sanchez, E" uniqKey="Sanchez E">E. Sánchez</name></author><author><name sortKey="Delgado, A" uniqKey="Delgado A">A. Delgado</name></author><author><name sortKey="Perera, A" uniqKey="Perera A">A. Perera</name></author><author><name sortKey="Evora, C" uniqKey="Evora C">C. Evora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, J" uniqKey="Chou J">J. Chou</name></author><author><name sortKey="Ben Nissan, B" uniqKey="Ben Nissan B">B. Ben-Nissan</name></author><author><name sortKey="Green, D W" uniqKey="Green D">D.W. Green</name></author><author><name sortKey="Valenzuela, S M" uniqKey="Valenzuela S">S.M. Valenzuela</name></author><author><name sortKey="Kohan, L" uniqKey="Kohan L">L. Kohan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aviv, M" uniqKey="Aviv M">M. Aviv</name></author><author><name sortKey="Berdicevsky, I" uniqKey="Berdicevsky I">I. Berdicevsky</name></author><author><name sortKey="Zilberman, M" uniqKey="Zilberman M">M. 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Milthorpe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammadi, G" uniqKey="Mohammadi G">G. Mohammadi</name></author><author><name sortKey="Barzegar Jalali, M" uniqKey="Barzegar Jalali M">M. Barzegar-Jalali</name></author><author><name sortKey="Valizadeh, H" uniqKey="Valizadeh H">H. Valizadeh</name></author><author><name sortKey="Nazemiyeh, H" uniqKey="Nazemiyeh H">H. Nazemiyeh</name></author><author><name sortKey="Barzegar Jalali, A" uniqKey="Barzegar Jalali A">A. Barzegar-Jalali</name></author><author><name sortKey="Siahi Shadbad, M R" uniqKey="Siahi Shadbad M">M.R. Siahi Shadbad</name></author><author><name sortKey="Adibkia, K" uniqKey="Adibkia K">K. Adibkia</name></author><author><name sortKey="Zare, M" uniqKey="Zare M">M. Zare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liechty, W B" uniqKey="Liechty W">W.B. Liechty</name></author><author><name sortKey="Kryscio, D R" uniqKey="Kryscio D">D.R. Kryscio</name></author><author><name sortKey="Slaughter, B V" uniqKey="Slaughter B">B.V. Slaughter</name></author><author><name sortKey="Peppas, N A" uniqKey="Peppas N">N.A. Peppas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costa, P" uniqKey="Costa P">P. Costa</name></author><author><name sortKey="Sousa Lobo, J M" uniqKey="Sousa Lobo J">J.M. Sousa Lobo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ford Versypt, A N" uniqKey="Ford Versypt A">A.N. Ford Versypt</name></author><author><name sortKey="Pack, D W" uniqKey="Pack D">D.W. Pack</name></author><author><name sortKey="Braatz, R D" uniqKey="Braatz R">R.D. Braatz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buzarovska, A" uniqKey="Buzarovska A">A. Buzarovska</name></author><author><name sortKey="Grozdanov, A" uniqKey="Grozdanov A">A. Grozdanov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, C L" uniqKey="Nelson C">C.L. Nelson</name></author><author><name sortKey="Mclaren, S G" uniqKey="Mclaren S">S.G. McLaren</name></author><author><name sortKey="Skinner, R A" uniqKey="Skinner R">R.A. Skinner</name></author><author><name sortKey="Smeltzer, M S" uniqKey="Smeltzer M">M.S. Smeltzer</name></author><author><name sortKey="Thomas, J R" uniqKey="Thomas J">J.R. Thomas</name></author><author><name sortKey="Olsen, K M" uniqKey="Olsen K">K.M. Olsen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chou, J" uniqKey="Chou J">J. Chou</name></author><author><name sortKey="Valenzuela, S" uniqKey="Valenzuela S">S. Valenzuela</name></author><author><name sortKey="Green, D W" uniqKey="Green D">D.W. Green</name></author><author><name sortKey="Kohan, L" uniqKey="Kohan L">L. Kohan</name></author><author><name sortKey="Milthorpe, B" uniqKey="Milthorpe B">B. Milthorpe</name></author><author><name sortKey="Otsuka, M" uniqKey="Otsuka M">M. Otsuka</name></author><author><name sortKey="Ben Nissan, B" uniqKey="Ben Nissan B">B. Ben-Nissan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hogan, J" uniqKey="Hogan J">J. Hogan</name></author><author><name sortKey="Shue, P I" uniqKey="Shue P">P.I. Shue</name></author><author><name sortKey="Podczeck, F" uniqKey="Podczeck F">F. Podczeck</name></author><author><name sortKey="Newton, J M" uniqKey="Newton J">J.M. Newton</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery.</title><author><name sortKey="Macha, Innocent J" sort="Macha, Innocent J" uniqKey="Macha I" first="Innocent J" last="Macha">Innocent J. Macha</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. innocent.macha@uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007</wicri:regionArea><wicri:noRegion>Ultimo NSW 2007</wicri:noRegion></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation wicri:level="1"><nlm:affiliation>CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France. sophie.cazalbou@univ-tlse3.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse</wicri:regionArea><wicri:noRegion>31030 Toulouse</wicri:noRegion><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region></placeName></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. Besim.Ben-Nissan@uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007</wicri:regionArea><wicri:noRegion>Ultimo NSW 2007</wicri:noRegion></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L" last="Harvey">Kate L. Harvey</name><affiliation wicri:level="1"><nlm:affiliation>The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia. Kate.l.harvey@student.uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007</wicri:regionArea><wicri:noRegion>Broadway NSW 2007</wicri:noRegion></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia. Bruce.Milthorpe@uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Science, University of Technology Sydney, Broadway NSW 2007</wicri:regionArea><wicri:noRegion>Broadway NSW 2007</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25608725</idno><idno type="pmid">25608725</idno><idno type="doi">10.3390/md13010666</idno><idno type="wicri:Area/PubMed/Corpus">003171</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003171</idno><idno type="wicri:Area/PubMed/Curation">003061</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003061</idno><idno type="wicri:Area/PubMed/Checkpoint">003061</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003061</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Marine structure derived calcium phosphate-polymer biocomposites for local antibiotic delivery.</title><author><name sortKey="Macha, Innocent J" sort="Macha, Innocent J" uniqKey="Macha I" first="Innocent J" last="Macha">Innocent J. Macha</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. innocent.macha@uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007</wicri:regionArea><wicri:noRegion>Ultimo NSW 2007</wicri:noRegion></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation wicri:level="1"><nlm:affiliation>CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France. sophie.cazalbou@univ-tlse3.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse</wicri:regionArea><wicri:noRegion>31030 Toulouse</wicri:noRegion><placeName><settlement type="city">Toulouse</settlement><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Midi-Pyrénées</region></placeName></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation wicri:level="1"><nlm:affiliation>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia. Besim.Ben-Nissan@uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007</wicri:regionArea><wicri:noRegion>Ultimo NSW 2007</wicri:noRegion></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L" last="Harvey">Kate L. Harvey</name><affiliation wicri:level="1"><nlm:affiliation>The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia. Kate.l.harvey@student.uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007</wicri:regionArea><wicri:noRegion>Broadway NSW 2007</wicri:noRegion></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia. Bruce.Milthorpe@uts.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Faculty of Science, University of Technology Sydney, Broadway NSW 2007</wicri:regionArea><wicri:noRegion>Broadway NSW 2007</wicri:noRegion></affiliation></author></analytic><series><title level="j">Marine drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (administration & dosage)</term><term>Calcium Phosphates (administration & dosage)</term><term>Calcium Phosphates (chemistry)</term><term>Ceramics (chemistry)</term><term>Drug Delivery Systems (methods)</term><term>Gentamicins (administration & dosage)</term><term>Hydroxyapatites (chemistry)</term><term>Microbial Sensitivity Tests</term><term>Microscopy, Electron, Scanning</term><term>Polymers (administration & dosage)</term><term>Polymers (chemistry)</term><term>Staphylococcus aureus (drug effects)</term><term>Tensile Strength</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antibactériens (administration et posologie)</term><term>Céramiques ()</term><term>Gentamicine (administration et posologie)</term><term>Hydroxyapatites ()</term><term>Microscopie électronique à balayage</term><term>Phosphates de calcium ()</term><term>Phosphates de calcium (administration et posologie)</term><term>Polymères ()</term><term>Polymères (administration et posologie)</term><term>Résistance à la traction</term><term>Staphylococcus aureus ()</term><term>Systèmes de délivrance de médicaments ()</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Calcium Phosphates</term><term>Gentamicins</term><term>Polymers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium Phosphates</term><term>Hydroxyapatites</term><term>Polymers</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Gentamicine</term><term>Phosphates de calcium</term><term>Polymères</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Ceramics</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Delivery Systems</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term><term>Microscopy, Electron, Scanning</term><term>Tensile Strength</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Céramiques</term><term>Hydroxyapatites</term><term>Microscopie électronique à balayage</term><term>Phosphates de calcium</term><term>Polymères</term><term>Résistance à la traction</term><term>Staphylococcus aureus</term><term>Systèmes de délivrance de médicaments</term><term>Tests de sensibilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against Staphylococcus aureus (S. aureus) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by S. aureus in surgery.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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