Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery
Identifieur interne : 002594 ( Pmc/Curation ); précédent : 002593; suivant : 002595Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery
Auteurs : Innocent J. Macha ; Sophie Cazalbou ; Besim Ben-Nissan ; Kate L. Harvey ; Bruce MilthorpeSource :
- Marine Drugs [ 1660-3397 ] ; 2015.
Abstract
Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca2+ for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against
Url:
DOI: 10.3390/md13010666
PubMed: 25608725
PubMed Central: 4306957
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery</title><author><name sortKey="Macha, Innocent J" sort="Macha, Innocent J" uniqKey="Macha I" first="Innocent J." last="Macha">Innocent J. Macha</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation><nlm:aff id="af2-marinedrugs-13-00666">CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></nlm:aff></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L." last="Harvey">Kate L. Harvey</name><affiliation><nlm:aff id="af3-marinedrugs-13-00666">The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Kate.l.harvey@student.uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation><nlm:aff id="af4-marinedrugs-13-00666">Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Bruce.Milthorpe@uts.edu.au</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25608725</idno><idno type="pmc">4306957</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306957</idno><idno type="RBID">PMC:4306957</idno><idno type="doi">10.3390/md13010666</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002744</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002744</idno><idno type="wicri:Area/Pmc/Curation">002594</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002594</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery</title><author><name sortKey="Macha, Innocent J" sort="Macha, Innocent J" uniqKey="Macha I" first="Innocent J." last="Macha">Innocent J. Macha</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Cazalbou, Sophie" sort="Cazalbou, Sophie" uniqKey="Cazalbou S" first="Sophie" last="Cazalbou">Sophie Cazalbou</name><affiliation><nlm:aff id="af2-marinedrugs-13-00666">CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></nlm:aff></affiliation></author><author><name sortKey="Ben Nissan, Besim" sort="Ben Nissan, Besim" uniqKey="Ben Nissan B" first="Besim" last="Ben-Nissan">Besim Ben-Nissan</name><affiliation><nlm:aff id="af1-marinedrugs-13-00666">School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Harvey, Kate L" sort="Harvey, Kate L" uniqKey="Harvey K" first="Kate L." last="Harvey">Kate L. Harvey</name><affiliation><nlm:aff id="af3-marinedrugs-13-00666">The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Kate.l.harvey@student.uts.edu.au</email></nlm:aff></affiliation></author><author><name sortKey="Milthorpe, Bruce" sort="Milthorpe, Bruce" uniqKey="Milthorpe B" first="Bruce" last="Milthorpe">Bruce Milthorpe</name><affiliation><nlm:aff id="af4-marinedrugs-13-00666">Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Bruce.Milthorpe@uts.edu.au</email></nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca<sup>2+</sup> for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against <italic>Staphylococcus aureus</italic> (<italic>S. aureus</italic>) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by <italic>S. aureus</italic> in surgery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ginebra, M P" uniqKey="Ginebra M">M.P. Ginebra</name></author><author><name sortKey="Traykova, T" uniqKey="Traykova T">T. Traykova</name></author><author><name sortKey="Planell, J A" uniqKey="Planell J">J.A. Planell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Habibe, A F" uniqKey="Habibe A">A.F. Habibe</name></author><author><name sortKey="Maeda, L D" uniqKey="Maeda L">L.D. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id><journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id><journal-id journal-id-type="publisher-id">marinedrugs</journal-id><journal-title-group><journal-title>Marine Drugs</journal-title></journal-title-group><issn pub-type="epub">1660-3397</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25608725</article-id><article-id pub-id-type="pmc">4306957</article-id><article-id pub-id-type="doi">10.3390/md13010666</article-id><article-id pub-id-type="publisher-id">marinedrugs-13-00666</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Marine Structure Derived Calcium Phosphate–Polymer Biocomposites for Local Antibiotic Delivery</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Macha</surname><given-names>Innocent J.</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-13-00666">1</xref></contrib><contrib contrib-type="author"><name><surname>Cazalbou</surname><given-names>Sophie</given-names></name><xref ref-type="aff" rid="af2-marinedrugs-13-00666">2</xref></contrib><contrib contrib-type="author"><name><surname>Ben-Nissan</surname><given-names>Besim</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-13-00666">1</xref><xref rid="c1-marinedrugs-13-00666" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Harvey</surname><given-names>Kate L.</given-names></name><xref ref-type="aff" rid="af3-marinedrugs-13-00666">3</xref></contrib><contrib contrib-type="author"><name><surname>Milthorpe</surname><given-names>Bruce</given-names></name><xref ref-type="aff" rid="af4-marinedrugs-13-00666">4</xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Zjawiony</surname><given-names>Jordan K.</given-names></name><role>Academic Editor</role></contrib></contrib-group><aff id="af1-marinedrugs-13-00666"><label>1</label>School of Chemistry and Forensic Science, University of Technology Sydney, Ultimo NSW 2007, Australia; E-Mail:<email>innocent.macha@uts.edu.au</email></aff><aff id="af2-marinedrugs-13-00666"><label>2</label>CIRIMAT Carnot Institute, CNRS-INPT-UPS, University of Toulouse, 31030 Toulouse, France; E-Mail:<email>sophie.cazalbou@univ-tlse3.fr</email></aff><aff id="af3-marinedrugs-13-00666"><label>3</label>The ithree Institute, Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Kate.l.harvey@student.uts.edu.au</email></aff><aff id="af4-marinedrugs-13-00666"><label>4</label>Faculty of Science, University of Technology Sydney, Broadway NSW 2007, Australia; E-Mail:<email>Bruce.Milthorpe@uts.edu.au</email></aff><author-notes><corresp id="c1-marinedrugs-13-00666"><label>*</label>Author to whom correspondence should be addressed; E-Mail: <email>Besim.Ben-Nissan@uts.edu.au</email>; Tel.: +61-2-9514-1784.</corresp></author-notes><pub-date pub-type="epub"><day>20</day><month>1</month><year>2015</year></pub-date><pub-date pub-type="collection"><month>1</month><year>2015</year></pub-date><volume>13</volume><issue>1</issue><fpage>666</fpage><lpage>680</lpage><history><date date-type="received"><day>13</day><month>11</month><year>2014</year></date><date date-type="accepted"><day>12</day><month>1</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2015</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><abstract><p>Hydrothermally converted coralline hydroxyapatite (HAp) particles loaded with medically active substances were used to develop polylactic acid (PLA) thin film composites for slow drug delivery systems. The effects of HAp particles within PLA matrix on the gentamicin (GM) release and release kinetics were studied. The gentamicin release kinetics seemed to follow Power law Korsmeyer Peppas model with mainly diffusional process with a number of different drug transport mechanisms. Statistical analysis shows very significant difference on the release of gentamicin between GM containing PLA (PLAGM) and GM containing HAp microspheres within PLA matrix (PLAHApGM) devices, which PLAHApGM displays lower release rates. The use of HAp particles improved drug stabilization and higher drug encapsulation efficiency of the carrier. HAp is also the source of Ca<sup>2+</sup> for the regeneration and repair of diseased bone tissue. The release profiles, exhibited a steady state release rate with significant antimicrobial activity against <italic>Staphylococcus aureus</italic> (<italic>S. aureus</italic>) (SH1000) even at high concentration of bacteria. The devices also indicated significant ability to control the growth of bacterial even after four weeks of drug release. Clinical release profiles can be easily tuned from drug-HAp physicochemical interactions and degradation kinetics of polymer matrix. The developed systems could be applied to prevent microbial adhesion to medical implant surfaces and to treat infections mainly caused by <italic>S. aureus</italic> in surgery.</p></abstract><kwd-group><kwd>drug release</kwd><kwd>thin film composites</kwd><kwd>coral</kwd><kwd>hydroxyapatite</kwd><kwd>microbial adhesion</kwd><kwd><italic>S. aureus</italic></kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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