Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study.
Identifieur interne : 002087 ( Ncbi/Merge ); précédent : 002086; suivant : 002088Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study.
Auteurs : Karin R Dholm [Suède] ; Hisatomi Arima [Australie] ; Richard I. Lindley [Australie] ; Jiguang Wang [République populaire de Chine] ; Christophe Tzourio [France] ; Thompson Robinson [Royaume-Uni] ; Emma Heeley [Australie] ; Craig S. Anderson [Australie] ; John Chalmers [Australie]Source :
- Age and ageing [ 1468-2834 ] ; 2015.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (), Accident vasculaire cérébral (mortalité), Accident vasculaire cérébral (épidémiologie), Adulte, Adulte d'âge moyen, Facteurs de l'âge, Femelle, Humains, Hémorragie cérébrale (), Hémorragie cérébrale (mortalité), Hémorragie cérébrale (épidémiologie), Jeune adulte, Mâle, Personnes handicapées (), Qualité de vie, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- mortalité : Accident vasculaire cérébral, Hémorragie cérébrale.
- épidémiologie : Accident vasculaire cérébral, Hémorragie cérébrale.
- Accident vasculaire cérébral, Adulte, Adulte d'âge moyen, Facteurs de l'âge, Femelle, Humains, Hémorragie cérébrale, Jeune adulte, Mâle, Personnes handicapées, Qualité de vie, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Cerebral Hemorrhage (epidemiology), Cerebral Hemorrhage (mortality), Cerebral Hemorrhage (therapy), Disabled Persons (statistics & numerical data), Female, Humans, Male, Middle Aged, Quality of Life, Stroke (epidemiology), Stroke (mortality), Stroke (therapy), Treatment Outcome, Young Adult.
- MESH :
- epidemiology : Cerebral Hemorrhage, Stroke.
- mortality : Cerebral Hemorrhage, Stroke.
- statistics & numerical data : Disabled Persons.
- therapy : Cerebral Hemorrhage, Stroke.
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Quality of Life, Treatment Outcome, Young Adult.
Abstract
Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study.
DOI: 10.1093/ageing/afu198
PubMed: 25497513
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pubmed:25497513Le document en format XML
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Anderson</name><affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="1"><nlm:affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">Age and ageing</title><idno type="eISSN">1468-2834</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Cerebral Hemorrhage (epidemiology)</term><term>Cerebral Hemorrhage (mortality)</term><term>Cerebral Hemorrhage (therapy)</term><term>Disabled Persons (statistics & numerical data)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Stroke (epidemiology)</term><term>Stroke (mortality)</term><term>Stroke (therapy)</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral ()</term><term>Accident vasculaire cérébral (mortalité)</term><term>Accident vasculaire cérébral (épidémiologie)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale ()</term><term>Hémorragie cérébrale (mortalité)</term><term>Hémorragie cérébrale (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Personnes handicapées ()</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cerebral Hemorrhage</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cerebral Hemorrhage</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Disabled Persons</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cerebral Hemorrhage</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale</term><term>Jeune adulte</term><term>Mâle</term><term>Personnes handicapées</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25497513</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>28</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>08</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-2834</ISSN><JournalIssue CitedMedium="Internet"><Volume>44</Volume><Issue>3</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Age and ageing</Title><ISOAbbreviation>Age Ageing</ISOAbbreviation></Journal><ArticleTitle>Older age is a strong predictor for poor outcome in intracerebral haemorrhage: the INTERACT2 study.</ArticleTitle><Pagination><MedlinePgn>422-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/ageing/afu198</ELocationID><Abstract><AbstractText Label="BACKGROUND AND PURPOSE" NlmCategory="OBJECTIVE">Global ageing contributes greatly to the burden of stroke. We investigated the influence of age on the baseline profile and on outcomes in acute intracerebral haemorrhage (ICH) among participants of the INTERACT2 study.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">INTERACT2 was an international, randomised controlled trial in 2839 patients with spontaneous ICH within 6 h of onset and elevated systolic blood pressure (SBP; 150-220 mmHg) who were allocated to receive intensive (target SBP <140 mmHg within 1 h) or guideline-recommended (target SBP <180 mmHg) blood pressure lowering treatment. Stroke severity was assessed with the National Institutes of Health Stroke Scale. Poor outcome was defined as death or major disability ('dependency', modified Rankin Scale scores 3-6) at 90 days. Health-related quality of life (HRQoL) was assessed with the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. Associations between age and outcomes were analysed in multivariable logistic regression models.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Stroke severity increased in categories of older age (P-trend 0.002). Stroke patients over 75 years old were four times more likely to die or be disabled at 90 days than those <52 years when other confounders were accounted for (odds ratio 4.36, 95% confidence interval 3.12-6.08). Older age was also associated with decreasing HRQoL, across mobility, self-care, usual activities and depression (all P-trend <0.001), and pain or discomfort (P-trend 0.022).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In the INTERACT2 cohort, older people had more severe ICH and worse outcomes (death, major disability and HRQoL). These data will help guide clinicians manage older people with haemorrhagic stroke.</AbstractText><AbstractText Label="CLINICAL TRIAL REGISTRATION" NlmCategory="BACKGROUND">http://www.clinicaltrials.gov (NCT00716079).</AbstractText><CopyrightInformation>© The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rådholm</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Community Medicine, Primary Care, Department of Medicine and Health Sciences, Faculty of Health Sciences, Department of Local Care West, Linköping University, County Council of Östergötland, Linköping, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arima</LastName><ForeName>Hisatomi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindley</LastName><ForeName>Richard I</ForeName><Initials>RI</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jiguang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM U897, Bordeaux, France University of Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Thompson</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heeley</LastName><ForeName>Emma</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Craig S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chalmers</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The George Institute for Global Health, University of Sydney and Royal Prince Alfred Hospital, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>INTERACT2 Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00716079</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>12</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Age Ageing</MedlineTA><NlmUniqueID>0375655</NlmUniqueID><ISSNLinking>0002-0729</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002543" MajorTopicYN="N">Cerebral Hemorrhage</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006233" MajorTopicYN="N">Disabled Persons</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ageing</Keyword><Keyword MajorTopicYN="N">death</Keyword><Keyword MajorTopicYN="N">dependency</Keyword><Keyword MajorTopicYN="N">intracerebral haemorrhage</Keyword><Keyword MajorTopicYN="N">quality of life</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25497513</ArticleId><ArticleId IdType="pii">afu198</ArticleId><ArticleId IdType="doi">10.1093/ageing/afu198</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suède</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><country name="Suède"><noRegion><name sortKey="R Dholm, Karin" sort="R Dholm, Karin" uniqKey="R Dholm K" first="Karin" last="R Dholm">Karin R Dholm</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></noRegion><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S" last="Anderson">Craig S. Anderson</name><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name><name sortKey="Lindley, Richard I" sort="Lindley, Richard I" uniqKey="Lindley R" first="Richard I" last="Lindley">Richard I. Lindley</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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