Very low levels of atherogenic lipoproteins and risk of cardiovascular events; a meta-analysis of statin trials
Identifieur interne : 001C80 ( Ncbi/Merge ); précédent : 001C79; suivant : 001C81Very low levels of atherogenic lipoproteins and risk of cardiovascular events; a meta-analysis of statin trials
Auteurs : S. Matthijs Boekholdt [Pays-Bas] ; G. Kees Hovingh [Pays-Bas] ; Samia Mora [États-Unis] ; Benoit J. Arsenault [Pays-Bas] ; Pierre Amarenco [France] ; Terje R. Pedersen [Norvège] ; John C. Larosa ; David D. Waters [États-Unis] ; David A. Demicco [États-Unis] ; R. John Simes [Australie] ; Antony C. Keech [Australie] ; David Colquhoun [Australie] ; Graham A. Hitman [Royaume-Uni] ; D. John Betteridge [Royaume-Uni] ; Michael B. Clearfield ; John R. Downs [États-Unis] ; Helen M. Colhoun [Royaume-Uni] ; Antonio M. Gotto [États-Unis] ; Paul M. Ridker [États-Unis] ; Scott M. Grundy [États-Unis] ; John J. P. Kastelein [Pays-Bas]Source :
- Journal of the American College of Cardiology [ 0735-1097 ] ; 2014.
Descripteurs français
- KwdFr :
- Athérosclérose (sang), Athérosclérose (traitement médicamenteux), Athérosclérose (épidémiologie), Essais contrôlés randomisés comme sujet, Facteurs de risque, Humains, Incidence, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique), Lipoprotéines (), Lipoprotéines (sang), Maladies cardiovasculaires (), Maladies cardiovasculaires (sang), Maladies cardiovasculaires (traitement médicamenteux), Marqueurs biologiques (sang), Santé mondiale.
- MESH :
- sang : Athérosclérose, Lipoprotéines, Maladies cardiovasculaires, Marqueurs biologiques.
- traitement médicamenteux : Athérosclérose, Maladies cardiovasculaires.
- usage thérapeutique : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- épidémiologie : Athérosclérose.
- Essais contrôlés randomisés comme sujet, Facteurs de risque, Humains, Incidence, Lipoprotéines, Maladies cardiovasculaires, Santé mondiale.
English descriptors
- KwdEn :
- Atherosclerosis (blood), Atherosclerosis (drug therapy), Atherosclerosis (epidemiology), Biomarkers (blood), Cardiovascular Diseases (blood), Cardiovascular Diseases (drug therapy), Cardiovascular Diseases (prevention & control), Global Health, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Incidence, Lipoproteins (blood), Lipoproteins (drug effects), Randomized Controlled Trials as Topic, Risk Factors.
- MESH :
- chemical , blood : Biomarkers, Lipoproteins.
- blood : Atherosclerosis, Cardiovascular Diseases.
- chemical , drug effects : Lipoproteins.
- drug therapy : Atherosclerosis, Cardiovascular Diseases.
- epidemiology : Atherosclerosis.
- prevention & control : Cardiovascular Diseases.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- Global Health, Humans, Incidence, Randomized Controlled Trials as Topic, Risk Factors.
Abstract
To evaluate (1) the inter-individual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) or apolipoprotein B (apoB) levels achieved with statin therapy, (2) the proportion of patients not reaching guideline-recommended lipid levels on high-dose statin therapy, and (3) the association between very low levels of atherogenic lipoproteins achieved with statin therapy and CVD risk.
Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease (CVD) risk is not well documented.
Meta-analysis of individual patient data from 8 randomized controlled statin trials in which conventional lipids and apolipoproteins were determined in all study participants at baseline and at 1-year follow-up.
Among 38,153 patients allocated to statin therapy, a total of 6,286 major cardiovascular events occurred in 5,387 study participants during follow-up. There was large inter-individual variability in the reductions of LDL-C, non-HDL-C and apoB achieved with a fixed statin dose. Over 40% of trial participants assigned to high-dose statin therapy did not reach an LDL-C target below 70 mg/dL. Compared to patients who achieved an LDL-C > 175 mg/dL, those who reached an LDL-C 75-100 mg/dL, 50-75 mg/dL and < 50 mg/dL had adjusted hazard ratios for major cardiovascular events of 0.56 (95%CI 0.46-0.67), 0.51 (95%CI 0.42-0,62) and 0.44 (95%CI 0.35-0.55), respectively. Similar associations were observed for non-HDL-C and apoB.
The reduction of LDL-C, non-HDL-C and apoB levels achieved with statin therapy displays large inter-individual variation. Among trial participants treated with high-dose statin therapy, over 40% do not reach an LDL-C target <70 mg/dL. Patients who achieve very low LDL-C levels have a lower risk of major cardiovascular events than those achieving moderately low levels.
Url:
DOI: 10.1016/j.jacc.2014.02.615
PubMed: 25082583
PubMed Central: 4443441
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PMC:4443441Le document en format XML
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Keech, Antony C" sort="Keech, Antony C" uniqKey="Keech A" first="Antony C." last="Keech">Antony C. Keech</name>
<affiliation wicri:level="4"><nlm:aff id="A9">NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Colquhoun, David" sort="Colquhoun, David" uniqKey="Colquhoun D" first="David" last="Colquhoun">David Colquhoun</name>
<affiliation wicri:level="1"><nlm:aff id="A10">The Wesley Hospital, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Wesley Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A." last="Hitman">Graham A. Hitman</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D. John" last="Betteridge">D. John Betteridge</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Endocrinology and Diabetes, University College Hospital, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B." last="Clearfield">Michael B. Clearfield</name>
<affiliation><nlm:aff id="A13">Touro University, Mare Island, California; Department of Medicine</nlm:aff>
<wicri:noCountry code="subfield">California; Department of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R." last="Downs">John R. Downs</name>
<affiliation wicri:level="2"><nlm:aff id="A14">University of Texas Health Science Center, San Antonio, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>University of Texas Health Science Center, San Antonio</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">VERDICT, South Texas Veterans Health Care System, San Antonio, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>VERDICT, South Texas Veterans Health Care System, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M." last="Colhoun">Helen M. Colhoun</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Medical Research Institute, University of Dundee, Dundee, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Institute, University of Dundee, Dundee</wicri:regionArea>
<wicri:noRegion>Dundee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M." last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Weill Cornell Medical College, New York, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grundy, Scott M" sort="Grundy, Scott M" uniqKey="Grundy S" first="Scott M." last="Grundy">Scott M. Grundy</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American College of Cardiology</title>
<idno type="ISSN">0735-1097</idno>
<idno type="eISSN">1558-3597</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (drug therapy)</term>
<term>Atherosclerosis (epidemiology)</term>
<term>Biomarkers (blood)</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (drug therapy)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Global Health</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term>
<term>Incidence</term>
<term>Lipoproteins (blood)</term>
<term>Lipoproteins (drug effects)</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Athérosclérose (sang)</term>
<term>Athérosclérose (traitement médicamenteux)</term>
<term>Athérosclérose (épidémiologie)</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Incidence</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term>
<term>Lipoprotéines ()</term>
<term>Lipoprotéines (sang)</term>
<term>Maladies cardiovasculaires ()</term>
<term>Maladies cardiovasculaires (sang)</term>
<term>Maladies cardiovasculaires (traitement médicamenteux)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Santé mondiale</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Lipoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Lipoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Athérosclérose</term>
<term>Lipoprotéines</term>
<term>Maladies cardiovasculaires</term>
<term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Athérosclérose</term>
<term>Maladies cardiovasculaires</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Athérosclérose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Global Health</term>
<term>Humans</term>
<term>Incidence</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Incidence</term>
<term>Lipoprotéines</term>
<term>Maladies cardiovasculaires</term>
<term>Santé mondiale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">To evaluate (1) the inter-individual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) or apolipoprotein B (apoB) levels achieved with statin therapy, (2) the proportion of patients not reaching guideline-recommended lipid levels on high-dose statin therapy, and (3) the association between very low levels of atherogenic lipoproteins achieved with statin therapy and CVD risk.</p>
</sec>
<sec id="S2"><title>Background</title>
<p id="P2">Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease (CVD) risk is not well documented.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Meta-analysis of individual patient data from 8 randomized controlled statin trials in which conventional lipids and apolipoproteins were determined in all study participants at baseline and at 1-year follow-up.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Among 38,153 patients allocated to statin therapy, a total of 6,286 major cardiovascular events occurred in 5,387 study participants during follow-up. There was large inter-individual variability in the reductions of LDL-C, non-HDL-C and apoB achieved with a fixed statin dose. Over 40% of trial participants assigned to high-dose statin therapy did not reach an LDL-C target below 70 mg/dL. Compared to patients who achieved an LDL-C > 175 mg/dL, those who reached an LDL-C 75-100 mg/dL, 50-75 mg/dL and < 50 mg/dL had adjusted hazard ratios for major cardiovascular events of 0.56 (95%CI 0.46-0.67), 0.51 (95%CI 0.42-0,62) and 0.44 (95%CI 0.35-0.55), respectively. Similar associations were observed for non-HDL-C and apoB.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">The reduction of LDL-C, non-HDL-C and apoB levels achieved with statin therapy displays large inter-individual variation. Among trial participants treated with high-dose statin therapy, over 40% do not reach an LDL-C target <70 mg/dL. Patients who achieve very low LDL-C levels have a lower risk of major cardiovascular events than those achieving moderately low levels.</p>
</sec>
</div>
</front>
</TEI>
<double pmid="25082583"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Very low levels of atherogenic lipoproteins and risk of cardiovascular events; a meta-analysis of statin trials</title>
<author><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S. Matthijs" last="Boekholdt">S. Matthijs Boekholdt</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G. Kees" last="Hovingh">G. Kees Hovingh</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arsenault, Benoit J" sort="Arsenault, Benoit J" uniqKey="Arsenault B" first="Benoit J." last="Arsenault">Benoit J. Arsenault</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Stroke Center, Bichat University Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R." last="Pedersen">Terje R. Pedersen</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo</wicri:regionArea>
<wicri:noRegion>Ulleval and University of Oslo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larosa, John C" sort="Larosa, John C" uniqKey="Larosa J" first="John C." last="Larosa">John C. Larosa</name>
<affiliation><nlm:aff id="A6">State University of New York Health Science Center, Brooklyn, New York (JCL)</nlm:aff>
<wicri:noCountry code="subfield">New York (JCL)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D." last="Waters">David D. Waters</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demicco, David A" sort="Demicco, David A" uniqKey="Demicco D" first="David A." last="Demicco">David A. Demicco</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Global Pharmaceuticals Pfizer, New York, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Global Pharmaceuticals Pfizer, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R. John" last="Simes">R. John Simes</name>
<affiliation wicri:level="4"><nlm:aff id="A9">NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Keech, Antony C" sort="Keech, Antony C" uniqKey="Keech A" first="Antony C." last="Keech">Antony C. Keech</name>
<affiliation wicri:level="4"><nlm:aff id="A9">NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Colquhoun, David" sort="Colquhoun, David" uniqKey="Colquhoun D" first="David" last="Colquhoun">David Colquhoun</name>
<affiliation wicri:level="1"><nlm:aff id="A10">The Wesley Hospital, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Wesley Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A." last="Hitman">Graham A. Hitman</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D. John" last="Betteridge">D. John Betteridge</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Endocrinology and Diabetes, University College Hospital, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B." last="Clearfield">Michael B. Clearfield</name>
<affiliation><nlm:aff id="A13">Touro University, Mare Island, California; Department of Medicine</nlm:aff>
<wicri:noCountry code="subfield">California; Department of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R." last="Downs">John R. Downs</name>
<affiliation wicri:level="2"><nlm:aff id="A14">University of Texas Health Science Center, San Antonio, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>University of Texas Health Science Center, San Antonio</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">VERDICT, South Texas Veterans Health Care System, San Antonio, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>VERDICT, South Texas Veterans Health Care System, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M." last="Colhoun">Helen M. Colhoun</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Medical Research Institute, University of Dundee, Dundee, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Institute, University of Dundee, Dundee</wicri:regionArea>
<wicri:noRegion>Dundee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M." last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Weill Cornell Medical College, New York, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grundy, Scott M" sort="Grundy, Scott M" uniqKey="Grundy S" first="Scott M." last="Grundy">Scott M. Grundy</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
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<idno type="doi">10.1016/j.jacc.2014.02.615</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">002020</idno>
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<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001266</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Very low levels of atherogenic lipoproteins and risk of cardiovascular events; a meta-analysis of statin trials</title>
<author><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S. Matthijs" last="Boekholdt">S. Matthijs Boekholdt</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G. Kees" last="Hovingh">G. Kees Hovingh</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arsenault, Benoit J" sort="Arsenault, Benoit J" uniqKey="Arsenault B" first="Benoit J." last="Arsenault">Benoit J. Arsenault</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Stroke Center, Bichat University Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R." last="Pedersen">Terje R. Pedersen</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo</wicri:regionArea>
<wicri:noRegion>Ulleval and University of Oslo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larosa, John C" sort="Larosa, John C" uniqKey="Larosa J" first="John C." last="Larosa">John C. Larosa</name>
<affiliation><nlm:aff id="A6">State University of New York Health Science Center, Brooklyn, New York (JCL)</nlm:aff>
<wicri:noCountry code="subfield">New York (JCL)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D." last="Waters">David D. Waters</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demicco, David A" sort="Demicco, David A" uniqKey="Demicco D" first="David A." last="Demicco">David A. Demicco</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Global Pharmaceuticals Pfizer, New York, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Global Pharmaceuticals Pfizer, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R. John" last="Simes">R. John Simes</name>
<affiliation wicri:level="4"><nlm:aff id="A9">NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Keech, Antony C" sort="Keech, Antony C" uniqKey="Keech A" first="Antony C." last="Keech">Antony C. Keech</name>
<affiliation wicri:level="4"><nlm:aff id="A9">NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Colquhoun, David" sort="Colquhoun, David" uniqKey="Colquhoun D" first="David" last="Colquhoun">David Colquhoun</name>
<affiliation wicri:level="1"><nlm:aff id="A10">The Wesley Hospital, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Wesley Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A." last="Hitman">Graham A. Hitman</name>
<affiliation wicri:level="4"><nlm:aff id="A11">Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D. John" last="Betteridge">D. John Betteridge</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Endocrinology and Diabetes, University College Hospital, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B." last="Clearfield">Michael B. Clearfield</name>
<affiliation><nlm:aff id="A13">Touro University, Mare Island, California; Department of Medicine</nlm:aff>
<wicri:noCountry code="subfield">California; Department of Medicine</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R." last="Downs">John R. Downs</name>
<affiliation wicri:level="2"><nlm:aff id="A14">University of Texas Health Science Center, San Antonio, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>University of Texas Health Science Center, San Antonio</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">VERDICT, South Texas Veterans Health Care System, San Antonio, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>VERDICT, South Texas Veterans Health Care System, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M." last="Colhoun">Helen M. Colhoun</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Medical Research Institute, University of Dundee, Dundee, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Institute, University of Dundee, Dundee</wicri:regionArea>
<wicri:noRegion>Dundee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M." last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Weill Cornell Medical College, New York, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, Massachusetts</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grundy, Scott M" sort="Grundy, Scott M" uniqKey="Grundy S" first="Scott M." last="Grundy">Scott M. Grundy</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J. P." last="Kastelein">John J. P. Kastelein</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American College of Cardiology</title>
<idno type="ISSN">0735-1097</idno>
<idno type="eISSN">1558-3597</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">To evaluate (1) the inter-individual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) or apolipoprotein B (apoB) levels achieved with statin therapy, (2) the proportion of patients not reaching guideline-recommended lipid levels on high-dose statin therapy, and (3) the association between very low levels of atherogenic lipoproteins achieved with statin therapy and CVD risk.</p>
</sec>
<sec id="S2"><title>Background</title>
<p id="P2">Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease (CVD) risk is not well documented.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Meta-analysis of individual patient data from 8 randomized controlled statin trials in which conventional lipids and apolipoproteins were determined in all study participants at baseline and at 1-year follow-up.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">Among 38,153 patients allocated to statin therapy, a total of 6,286 major cardiovascular events occurred in 5,387 study participants during follow-up. There was large inter-individual variability in the reductions of LDL-C, non-HDL-C and apoB achieved with a fixed statin dose. Over 40% of trial participants assigned to high-dose statin therapy did not reach an LDL-C target below 70 mg/dL. Compared to patients who achieved an LDL-C > 175 mg/dL, those who reached an LDL-C 75-100 mg/dL, 50-75 mg/dL and < 50 mg/dL had adjusted hazard ratios for major cardiovascular events of 0.56 (95%CI 0.46-0.67), 0.51 (95%CI 0.42-0,62) and 0.44 (95%CI 0.35-0.55), respectively. Similar associations were observed for non-HDL-C and apoB.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">The reduction of LDL-C, non-HDL-C and apoB levels achieved with statin therapy displays large inter-individual variation. Among trial participants treated with high-dose statin therapy, over 40% do not reach an LDL-C target <70 mg/dL. Patients who achieve very low LDL-C levels have a lower risk of major cardiovascular events than those achieving moderately low levels.</p>
</sec>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.</title>
<author><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S Matthijs" last="Boekholdt">S Matthijs Boekholdt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arsenault, Benoit J" sort="Arsenault, Benoit J" uniqKey="Arsenault B" first="Benoit J" last="Arsenault">Benoit J. Arsenault</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Stroke Center, Bichat University Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name>
<affiliation wicri:level="3"><nlm:affiliation>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Larosa, John C" sort="Larosa, John C" uniqKey="Larosa J" first="John C" last="Larosa">John C. Larosa</name>
<affiliation wicri:level="2"><nlm:affiliation>Health Science Center, State University of New York, Brooklyn, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Health Science Center, State University of New York, Brooklyn</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demicco, David A" sort="Demicco, David A" uniqKey="Demicco D" first="David A" last="Demicco">David A. Demicco</name>
<affiliation wicri:level="2"><nlm:affiliation>Global Pharmaceuticals, Pfizer Inc., New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Global Pharmaceuticals, Pfizer Inc., New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R John" last="Simes">R John Simes</name>
<affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Keech, Antony C" sort="Keech, Antony C" uniqKey="Keech A" first="Antony C" last="Keech">Antony C. Keech</name>
<affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Colquhoun, David" sort="Colquhoun, David" uniqKey="Colquhoun D" first="David" last="Colquhoun">David Colquhoun</name>
<affiliation wicri:level="1"><nlm:affiliation>The Wesley Hospital, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Wesley Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A" last="Hitman">Graham A. Hitman</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D John" last="Betteridge">D John Betteridge</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology and Diabetes, University College Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B" last="Clearfield">Michael B. Clearfield</name>
<affiliation wicri:level="2"><nlm:affiliation>Touro University, Mare Island, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Touro University, Mare Island</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; VERDICT, South Texas Veterans Health Care System, San Antonio, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; VERDICT, South Texas Veterans Health Care System, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M" last="Colhoun">Helen M. Colhoun</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Research Institute, University of Dundee, Dundee, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Institute, University of Dundee, Dundee</wicri:regionArea>
<wicri:noRegion>Dundee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grundy, Scott M" sort="Grundy, Scott M" uniqKey="Grundy S" first="Scott M" last="Grundy">Scott M. Grundy</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Human Nutrition, Southwestern Medical Center, University of Texas, Dallas, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Human Nutrition, Southwestern Medical Center, University of Texas, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: j.j.kastelein@amc.uva.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.</title>
<author><name sortKey="Boekholdt, S Matthijs" sort="Boekholdt, S Matthijs" uniqKey="Boekholdt S" first="S Matthijs" last="Boekholdt">S Matthijs Boekholdt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arsenault, Benoit J" sort="Arsenault, Benoit J" uniqKey="Arsenault B" first="Benoit J" last="Arsenault">Benoit J. Arsenault</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Stroke Center, Bichat University Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name>
<affiliation wicri:level="3"><nlm:affiliation>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Oslo, Norway.</nlm:affiliation>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Larosa, John C" sort="Larosa, John C" uniqKey="Larosa J" first="John C" last="Larosa">John C. Larosa</name>
<affiliation wicri:level="2"><nlm:affiliation>Health Science Center, State University of New York, Brooklyn, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Health Science Center, State University of New York, Brooklyn</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demicco, David A" sort="Demicco, David A" uniqKey="Demicco D" first="David A" last="Demicco">David A. Demicco</name>
<affiliation wicri:level="2"><nlm:affiliation>Global Pharmaceuticals, Pfizer Inc., New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Global Pharmaceuticals, Pfizer Inc., New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Simes, R John" sort="Simes, R John" uniqKey="Simes R" first="R John" last="Simes">R John Simes</name>
<affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Keech, Antony C" sort="Keech, Antony C" uniqKey="Keech A" first="Antony C" last="Keech">Antony C. Keech</name>
<affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Colquhoun, David" sort="Colquhoun, David" uniqKey="Colquhoun D" first="David" last="Colquhoun">David Colquhoun</name>
<affiliation wicri:level="1"><nlm:affiliation>The Wesley Hospital, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Wesley Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hitman, Graham A" sort="Hitman, Graham A" uniqKey="Hitman G" first="Graham A" last="Hitman">Graham A. Hitman</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Betteridge, D John" sort="Betteridge, D John" uniqKey="Betteridge D" first="D John" last="Betteridge">D John Betteridge</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Endocrinology and Diabetes, University College Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Endocrinology and Diabetes, University College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B" last="Clearfield">Michael B. Clearfield</name>
<affiliation wicri:level="2"><nlm:affiliation>Touro University, Mare Island, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Touro University, Mare Island</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; VERDICT, South Texas Veterans Health Care System, San Antonio, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; VERDICT, South Texas Veterans Health Care System, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M" last="Colhoun">Helen M. Colhoun</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Research Institute, University of Dundee, Dundee, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Institute, University of Dundee, Dundee</wicri:regionArea>
<wicri:noRegion>Dundee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, New York.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Grundy, Scott M" sort="Grundy, Scott M" uniqKey="Grundy S" first="Scott M" last="Grundy">Scott M. Grundy</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Human Nutrition, Southwestern Medical Center, University of Texas, Dallas, Texas.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Human Nutrition, Southwestern Medical Center, University of Texas, Dallas</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: j.j.kastelein@amc.uva.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American College of Cardiology</title>
<idno type="eISSN">1558-3597</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (drug therapy)</term>
<term>Atherosclerosis (epidemiology)</term>
<term>Biomarkers (blood)</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (drug therapy)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Global Health</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term>
<term>Incidence</term>
<term>Lipoproteins (blood)</term>
<term>Lipoproteins (drug effects)</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Athérosclérose (sang)</term>
<term>Athérosclérose (traitement médicamenteux)</term>
<term>Athérosclérose (épidémiologie)</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Incidence</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term>
<term>Lipoprotéines ()</term>
<term>Lipoprotéines (sang)</term>
<term>Maladies cardiovasculaires ()</term>
<term>Maladies cardiovasculaires (sang)</term>
<term>Maladies cardiovasculaires (traitement médicamenteux)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Santé mondiale</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
<term>Lipoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Lipoproteins</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Atherosclerosis</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Athérosclérose</term>
<term>Lipoprotéines</term>
<term>Maladies cardiovasculaires</term>
<term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Athérosclérose</term>
<term>Maladies cardiovasculaires</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Athérosclérose</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Global Health</term>
<term>Humans</term>
<term>Incidence</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Incidence</term>
<term>Lipoprotéines</term>
<term>Maladies cardiovasculaires</term>
<term>Santé mondiale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease risk is not well-documented.</div>
</front>
</TEI>
</pubmed>
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