AustralieFrV1, PubMed, Curation, bibRecord, 003420

Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.

Identifieur interne : 003420 ( PubMed/Curation ); précédent : 003419; suivant : 003421

Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.

Auteurs : S Matthijs Boekholdt [Pays-Bas] ; G Kees Hovingh [Pays-Bas] ; Samia Mora [États-Unis] ; Benoit J. Arsenault [Pays-Bas] ; Pierre Amarenco [France] ; Terje R. Pedersen [Norvège] ; John C. Larosa [États-Unis] ; David D. Waters [États-Unis] ; David A. Demicco [États-Unis] ; R John Simes [Australie] ; Antony C. Keech [Australie] ; David Colquhoun [Australie] ; Graham A. Hitman [Royaume-Uni] ; D John Betteridge [Royaume-Uni] ; Michael B. Clearfield [États-Unis] ; John R. Downs [États-Unis] ; Helen M. Colhoun [Royaume-Uni] ; Antonio M. Gotto [États-Unis] ; Paul M. Ridker [États-Unis] ; Scott M. Grundy [États-Unis] ; John J P. Kastelein [Pays-Bas]

Source :

Journal of the American College of Cardiology [ 1558-3597 ] ; 2014.

RBID : pubmed:25082583

Descripteurs français

KwdFr :
- Athérosclérose (sang), Athérosclérose (traitement médicamenteux), Athérosclérose (épidémiologie), Essais contrôlés randomisés comme sujet, Facteurs de risque, Humains, Incidence, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique), Lipoprotéines (), Lipoprotéines (sang), Maladies cardiovasculaires (), Maladies cardiovasculaires (sang), Maladies cardiovasculaires (traitement médicamenteux), Marqueurs biologiques (sang), Santé mondiale.
MESH :
- sang : Athérosclérose, Lipoprotéines, Maladies cardiovasculaires, Marqueurs biologiques.
- traitement médicamenteux : Athérosclérose, Maladies cardiovasculaires.
- usage thérapeutique : Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- épidémiologie : Athérosclérose.
- Essais contrôlés randomisés comme sujet, Facteurs de risque, Humains, Incidence, Lipoprotéines, Maladies cardiovasculaires, Santé mondiale.

English descriptors

KwdEn :
- Atherosclerosis (blood), Atherosclerosis (drug therapy), Atherosclerosis (epidemiology), Biomarkers (blood), Cardiovascular Diseases (blood), Cardiovascular Diseases (drug therapy), Cardiovascular Diseases (prevention & control), Global Health, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Incidence, Lipoproteins (blood), Lipoproteins (drug effects), Randomized Controlled Trials as Topic, Risk Factors.
MESH :
- chemical , blood : Biomarkers, Lipoproteins.
- blood : Atherosclerosis, Cardiovascular Diseases.
- chemical , drug effects : Lipoproteins.
- drug therapy : Atherosclerosis, Cardiovascular Diseases.
- epidemiology : Atherosclerosis.
- prevention & control : Cardiovascular Diseases.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- Global Health, Humans, Incidence, Randomized Controlled Trials as Topic, Risk Factors.

Abstract

Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease risk is not well-documented.

DOI: 10.1016/j.jacc.2014.02.615
PubMed: 25082583

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.</title>
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<author><name sortKey="Clearfield, Michael B" sort="Clearfield, Michael B" uniqKey="Clearfield M" first="Michael B" last="Clearfield">Michael B. Clearfield</name>
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<author><name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; VERDICT, South Texas Veterans Health Care System, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen M" sort="Colhoun, Helen M" uniqKey="Colhoun H" first="Helen M" last="Colhoun">Helen M. Colhoun</name>
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<country xml:lang="fr">Royaume-Uni</country>
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</affiliation>
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<author><name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name>
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</placeName>
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<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
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</affiliation>
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<author><name sortKey="Grundy, Scott M" sort="Grundy, Scott M" uniqKey="Grundy S" first="Scott M" last="Grundy">Scott M. Grundy</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Center for Human Nutrition, Southwestern Medical Center, University of Texas, Dallas</wicri:cityArea>
</affiliation>
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<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: j.j.kastelein@amc.uva.nl.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, Amsterdam</wicri:regionArea>
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<series><title level="j">Journal of the American College of Cardiology</title>
<idno type="eISSN">1558-3597</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (drug therapy)</term>
<term>Atherosclerosis (epidemiology)</term>
<term>Biomarkers (blood)</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (drug therapy)</term>
<term>Cardiovascular Diseases (prevention & control)</term>
<term>Global Health</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term>
<term>Incidence</term>
<term>Lipoproteins (blood)</term>
<term>Lipoproteins (drug effects)</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Athérosclérose (sang)</term>
<term>Athérosclérose (traitement médicamenteux)</term>
<term>Athérosclérose (épidémiologie)</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Incidence</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (usage thérapeutique)</term>
<term>Lipoprotéines ()</term>
<term>Lipoprotéines (sang)</term>
<term>Maladies cardiovasculaires ()</term>
<term>Maladies cardiovasculaires (sang)</term>
<term>Maladies cardiovasculaires (traitement médicamenteux)</term>
<term>Marqueurs biologiques (sang)</term>
<term>Santé mondiale</term>
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<term>Maladies cardiovasculaires</term>
<term>Marqueurs biologiques</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
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<term>Maladies cardiovasculaires</term>
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<term>Humans</term>
<term>Incidence</term>
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<term>Incidence</term>
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<front><div type="abstract" xml:lang="en">Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease risk is not well-documented.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25082583</PMID>
<DateCreated><Year>2014</Year>
<Month>08</Month>
<Day>01</Day>
</DateCreated>
<DateCompleted><Year>2014</Year>
<Month>10</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1558-3597</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>64</Volume>
<Issue>5</Issue>
<PubDate><Year>2014</Year>
<Month>Aug</Month>
<Day>05</Day>
</PubDate>
</JournalIssue>
<Title>Journal of the American College of Cardiology</Title>
<ISOAbbreviation>J. Am. Coll. Cardiol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.</ArticleTitle>
<Pagination><MedlinePgn>485-94</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jacc.2014.02.615</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S0735-1097(14)02704-1</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease risk is not well-documented.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The aim of this meta-analysis was to evaluate: 1) the interindividual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), or apolipoprotein B (apoB) levels achieved with statin therapy; 2) the proportion of patients not reaching guideline-recommended lipid levels on high-dose statin therapy; and 3) the association between very low levels of atherogenic lipoproteins achieved with statin therapy and cardiovascular disease risk.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This meta-analysis used individual patient data from 8 randomized controlled statin trials, in which conventional lipids and apolipoproteins were determined in all study participants at baseline and at 1-year follow-up.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 38,153 patients allocated to statin therapy, a total of 6,286 major cardiovascular events occurred in 5,387 study participants during follow-up. There was large interindividual variability in the reductions of LDL-C, non-HDL-C, and apoB achieved with a fixed statin dose. More than 40% of trial participants assigned to high-dose statin therapy did not reach an LDL-C target <70 mg/dl. Compared with patients who achieved an LDL-C >175 mg/dl, those who reached an LDL-C 75 to <100 mg/dl, 50 to <75 mg/dl, and <50 mg/dl had adjusted hazard ratios for major cardiovascular events of 0.56 (95% confidence interval [CI]: 0.46 to 0.67), 0.51 (95% CI: 0.42 to 0.62), and 0.44 (95% CI: 0.35 to 0.55), respectively. Similar associations were observed for non-HDL-C and apoB.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The reductions of LDL-C, non-HDL-C, and apoB levels achieved with statin therapy displayed large interindividual variation. Among trial participants treated with high-dose statin therapy, >40% did not reach an LDL-C target <70 mg/dl. Patients who achieve very low LDL-C levels have a lower risk for major cardiovascular events than do those achieving moderately low levels.</AbstractText>
<CopyrightInformation>Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boekholdt</LastName>
<ForeName>S Matthijs</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hovingh</LastName>
<ForeName>G Kees</ForeName>
<Initials>GK</Initials>
<AffiliationInfo><Affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mora</LastName>
<ForeName>Samia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Arsenault</LastName>
<ForeName>Benoit J</ForeName>
<Initials>BJ</Initials>
<AffiliationInfo><Affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Amarenco</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Neurology and Stroke Center, Bichat University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pedersen</LastName>
<ForeName>Terje R</ForeName>
<Initials>TR</Initials>
<AffiliationInfo><Affiliation>Center of Preventive Medicine, Oslo University Hospital, Ulleval and University of Oslo, Oslo, Norway.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>LaRosa</LastName>
<ForeName>John C</ForeName>
<Initials>JC</Initials>
<AffiliationInfo><Affiliation>Health Science Center, State University of New York, Brooklyn, New York.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Waters</LastName>
<ForeName>David D</ForeName>
<Initials>DD</Initials>
<AffiliationInfo><Affiliation>Division of Cardiology, San Francisco General Hospital and the University of California at San Francisco, San Francisco, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>DeMicco</LastName>
<ForeName>David A</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>Global Pharmaceuticals, Pfizer Inc., New York, New York.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Simes</LastName>
<ForeName>R John</ForeName>
<Initials>RJ</Initials>
<AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Keech</LastName>
<ForeName>Antony C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Colquhoun</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>The Wesley Hospital, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hitman</LastName>
<ForeName>Graham A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>Centre for Diabetes, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Betteridge</LastName>
<ForeName>D John</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology and Diabetes, University College Hospital, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Clearfield</LastName>
<ForeName>Michael B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Touro University, Mare Island, California.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Downs</LastName>
<ForeName>John R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, University of Texas Health Science Center, San Antonio, Texas; VERDICT, South Texas Veterans Health Care System, San Antonio, Texas.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Colhoun</LastName>
<ForeName>Helen M</ForeName>
<Initials>HM</Initials>
<AffiliationInfo><Affiliation>Medical Research Institute, University of Dundee, Dundee, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gotto</LastName>
<ForeName>Antonio M</ForeName>
<Initials>AM</Initials>
<Suffix>Jr</Suffix>
<AffiliationInfo><Affiliation>Weill Cornell Medical College, New York, New York.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ridker</LastName>
<ForeName>Paul M</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Grundy</LastName>
<ForeName>Scott M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Center for Human Nutrition, Southwestern Medical Center, University of Texas, Dallas, Texas.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kastelein</LastName>
<ForeName>John J P</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. Electronic address: j.j.kastelein@amc.uva.nl.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 HL117861</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
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<PublicationType UI="D017418">Meta-Analysis</PublicationType>
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<MedlineTA>J Am Coll Cardiol</MedlineTA>
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<ISSNLinking>0735-1097</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D050197" MajorTopicYN="Y">Atherosclerosis</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014943" MajorTopicYN="N">Global Health</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019161" MajorTopicYN="N">Hydroxymethylglutaryl-CoA Reductase Inhibitors</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008074" MajorTopicYN="N">Lipoproteins</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016032" MajorTopicYN="Y">Randomized Controlled Trials as Topic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">NIHMS690311</OtherID>
<OtherID Source="NLM">PMC4443441</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">LDL-cholesterol</Keyword>
<Keyword MajorTopicYN="N">apolipoprotein B</Keyword>
<Keyword MajorTopicYN="N">meta-analysis</Keyword>
<Keyword MajorTopicYN="N">non–HDL-cholesterol</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year>
<Month>11</Month>
<Day>03</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2014</Year>
<Month>01</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2014</Year>
<Month>02</Month>
<Day>17</Day>
</PubMedPubDate>
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<Month>8</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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   |texte=   Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.

Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.

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