AustralieFrV1, Ncbi, Merge, bibRecord, 001A55

Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

Identifieur interne : 001A55 ( Ncbi/Merge ); précédent : 001A54; suivant : 001A56

Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

Auteurs : Peter C. H. Feng [États-Unis] ; Sabine Delannoy [France] ; David W. Lacher [États-Unis] ; Luis Fernando Dos Santos [Brésil] ; Lothar Beutin [Allemagne] ; Patrick Fach [France] ; Marta Rivas [Argentine] ; Elizabeth L. Hartland [Australie] ; Adrienne W. Paton [Australie] ; Beatriz E. C. Guth [Brésil]

Source :

Applied and Environmental Microbiology [ 0099-2240 ] ; 2014.

RBID : PMC:4148811

Descripteurs français

KwdFr :
- Animaux, Bovins, Capra, Chiens, Données de séquences moléculaires, Escherichia coli producteur de Shiga-toxine (), Escherichia coli producteur de Shiga-toxine (génétique), Escherichia coli producteur de Shiga-toxine (isolement et purification), Escherichia coli producteur de Shiga-toxine (métabolisme), Facteurs de virulence (génétique), Fèces (microbiologie), Humains, Infections à Escherichia coli (microbiologie), Microbiologie alimentaire, Microbiologie de l'environnement, Phylogénie, Protéines Escherichia coli (génétique), Shiga-toxine (métabolisme), Variation génétique, Viande (microbiologie).
MESH :
- génétique : Escherichia coli producteur de Shiga-toxine, Facteurs de virulence, Protéines Escherichia coli.
- isolement et purification : Escherichia coli producteur de Shiga-toxine.
- microbiologie : Fèces, Infections à Escherichia coli, Viande.
- métabolisme : Escherichia coli producteur de Shiga-toxine, Shiga-toxine.
- Animaux, Bovins, Capra, Chiens, Données de séquences moléculaires, Escherichia coli producteur de Shiga-toxine, Humains, Microbiologie alimentaire, Microbiologie de l'environnement, Phylogénie, Variation génétique.

English descriptors

KwdEn :
- Animals, Cattle, Dogs, Environmental Microbiology, Escherichia coli Infections (microbiology), Escherichia coli Proteins (genetics), Feces (microbiology), Food Microbiology, Genetic Variation, Goats, Humans, Meat (microbiology), Molecular Sequence Data, Phylogeny, Shiga Toxin (metabolism), Shiga-Toxigenic Escherichia coli (classification), Shiga-Toxigenic Escherichia coli (genetics), Shiga-Toxigenic Escherichia coli (isolation & purification), Shiga-Toxigenic Escherichia coli (metabolism), Virulence Factors (genetics).
MESH :
- chemical , genetics : Escherichia coli Proteins, Virulence Factors.
- chemical , metabolism : Shiga Toxin.
- classification : Shiga-Toxigenic Escherichia coli.
- genetics : Shiga-Toxigenic Escherichia coli.
- isolation & purification : Shiga-Toxigenic Escherichia coli.
- metabolism : Shiga-Toxigenic Escherichia coli.
- microbiology : Escherichia coli Infections, Feces, Meat.
- Animals, Cattle, Dogs, Environmental Microbiology, Food Microbiology, Genetic Variation, Goats, Humans, Molecular Sequence Data, Phylogeny.

Abstract

Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148811

DOI: 10.1128/AEM.01182-14
PubMed: 24858089
PubMed Central: 4148811

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Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Shiga toxin-producing <named-content content-type="genus-species">Escherichia coli</named-content>
 strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.</p>
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 O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources</title>
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<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Microbiology, Food and Drug Administration, College Park, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Microbiology, Food and Drug Administration, College Park, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delannoy, Sabine" sort="Delannoy, Sabine" uniqKey="Delannoy S" first="Sabine" last="Delannoy">Sabine Delannoy</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacher, David W" sort="Lacher, David W" uniqKey="Lacher D" first="David W." last="Lacher">David W. Lacher</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos, Luis Fernando" sort="Dos Santos, Luis Fernando" uniqKey="Dos Santos L" first="Luis Fernando" last="Dos Santos">Luis Fernando Dos Santos</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beutin, Lothar" sort="Beutin, Lothar" uniqKey="Beutin L" first="Lothar" last="Beutin">Lothar Beutin</name>
<affiliation wicri:level="3"><nlm:aff id="aff5">National Reference Laboratory for<italic>Escherichia coli</italic>
, Federal Institute for Risk Assessment, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>, Federal Institute for Risk Assessment, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fach, Patrick" sort="Fach, Patrick" uniqKey="Fach P" first="Patrick" last="Fach">Patrick Fach</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivas, Marta" sort="Rivas, Marta" uniqKey="Rivas M" first="Marta" last="Rivas">Marta Rivas</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires</wicri:regionArea>
<wicri:noRegion>” Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L." last="Hartland">Elizabeth L. Hartland</name>
<affiliation wicri:level="3"><nlm:aff id="aff7">Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paton, Adrienne W" sort="Paton, Adrienne W" uniqKey="Paton A" first="Adrienne W." last="Paton">Adrienne W. Paton</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guth, Beatriz E C" sort="Guth, Beatriz E C" uniqKey="Guth B" first="Beatriz E. C." last="Guth">Beatriz E. C. Guth</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24858089</idno>
<idno type="pmc">4148811</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148811</idno>
<idno type="RBID">PMC:4148811</idno>
<idno type="doi">10.1128/AEM.01182-14</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001755</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001755</idno>
<idno type="wicri:Area/Pmc/Curation">001615</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001615</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001574</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001574</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic Diversity and Virulence Potential of Shiga Toxin-Producing <named-content content-type="genus-species">Escherichia coli</named-content>
 O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources</title>
<author><name sortKey="Feng, Peter C H" sort="Feng, Peter C H" uniqKey="Feng P" first="Peter C. H." last="Feng">Peter C. H. Feng</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Microbiology, Food and Drug Administration, College Park, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Microbiology, Food and Drug Administration, College Park, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delannoy, Sabine" sort="Delannoy, Sabine" uniqKey="Delannoy S" first="Sabine" last="Delannoy">Sabine Delannoy</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacher, David W" sort="Lacher, David W" uniqKey="Lacher D" first="David W." last="Lacher">David W. Lacher</name>
<affiliation wicri:level="2"><nlm:aff id="aff3">Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos, Luis Fernando" sort="Dos Santos, Luis Fernando" uniqKey="Dos Santos L" first="Luis Fernando" last="Dos Santos">Luis Fernando Dos Santos</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beutin, Lothar" sort="Beutin, Lothar" uniqKey="Beutin L" first="Lothar" last="Beutin">Lothar Beutin</name>
<affiliation wicri:level="3"><nlm:aff id="aff5">National Reference Laboratory for<italic>Escherichia coli</italic>
, Federal Institute for Risk Assessment, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>, Federal Institute for Risk Assessment, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fach, Patrick" sort="Fach, Patrick" uniqKey="Fach P" first="Patrick" last="Fach">Patrick Fach</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivas, Marta" sort="Rivas, Marta" uniqKey="Rivas M" first="Marta" last="Rivas">Marta Rivas</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS “Dr. Carlos G. Malbrán,” Buenos Aires</wicri:regionArea>
<wicri:noRegion>” Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L." last="Hartland">Elizabeth L. Hartland</name>
<affiliation wicri:level="3"><nlm:aff id="aff7">Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paton, Adrienne W" sort="Paton, Adrienne W" uniqKey="Paton A" first="Adrienne W." last="Paton">Adrienne W. Paton</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guth, Beatriz E C" sort="Guth, Beatriz E C" uniqKey="Guth B" first="Beatriz E. C." last="Guth">Beatriz E. C. Guth</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Applied and Environmental Microbiology</title>
<idno type="ISSN">0099-2240</idno>
<idno type="eISSN">1098-5336</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Shiga toxin-producing <named-content content-type="genus-species">Escherichia coli</named-content>
 strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.</p>
</div>
</front>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic diversity and virulence potential of shiga toxin-producing Escherichia coli O113:H21 strains isolated from clinical, environmental, and food sources.</title>
<author><name sortKey="Feng, Peter C H" sort="Feng, Peter C H" uniqKey="Feng P" first="Peter C H" last="Feng">Peter C H. Feng</name>
<affiliation><nlm:affiliation>Division of Microbiology, Food and Drug Administration, College Park, Maryland, USA peter.feng@fda.hhs.gov.</nlm:affiliation>
<wicri:noCountry code="subField">USA peter.feng@fda.hhs.gov.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Delannoy, Sabine" sort="Delannoy, Sabine" uniqKey="Delannoy S" first="Sabine" last="Delannoy">Sabine Delannoy</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacher, David W" sort="Lacher, David W" uniqKey="Lacher D" first="David W" last="Lacher">David W. Lacher</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos, Luis Fernando" sort="Dos Santos, Luis Fernando" uniqKey="Dos Santos L" first="Luis Fernando" last="Dos Santos">Luis Fernando Dos Santos</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beutin, Lothar" sort="Beutin, Lothar" uniqKey="Beutin L" first="Lothar" last="Beutin">Lothar Beutin</name>
<affiliation wicri:level="3"><nlm:affiliation>National Reference Laboratory for Escherichia coli, Federal Institute for Risk Assessment, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Reference Laboratory for Escherichia coli, Federal Institute for Risk Assessment, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fach, Patrick" sort="Fach, Patrick" uniqKey="Fach P" first="Patrick" last="Fach">Patrick Fach</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivas, Marta" sort="Rivas, Marta" uniqKey="Rivas M" first="Marta" last="Rivas">Marta Rivas</name>
<affiliation wicri:level="1"><nlm:affiliation>Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Buenos Aires, Argentina.</nlm:affiliation>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Buenos Aires</wicri:regionArea>
<wicri:noRegion>" Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L" last="Hartland">Elizabeth L. Hartland</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paton, Adrienne W" sort="Paton, Adrienne W" uniqKey="Paton A" first="Adrienne W" last="Paton">Adrienne W. Paton</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guth, Beatriz E C" sort="Guth, Beatriz E C" uniqKey="Guth B" first="Beatriz E C" last="Guth">Beatriz E C. Guth</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24858089</idno>
<idno type="pmid">24858089</idno>
<idno type="doi">10.1128/AEM.01182-14</idno>
<idno type="wicri:Area/PubMed/Corpus">003589</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003589</idno>
<idno type="wicri:Area/PubMed/Curation">003476</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003476</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003476</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003476</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic diversity and virulence potential of shiga toxin-producing Escherichia coli O113:H21 strains isolated from clinical, environmental, and food sources.</title>
<author><name sortKey="Feng, Peter C H" sort="Feng, Peter C H" uniqKey="Feng P" first="Peter C H" last="Feng">Peter C H. Feng</name>
<affiliation><nlm:affiliation>Division of Microbiology, Food and Drug Administration, College Park, Maryland, USA peter.feng@fda.hhs.gov.</nlm:affiliation>
<wicri:noCountry code="subField">USA peter.feng@fda.hhs.gov.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Delannoy, Sabine" sort="Delannoy, Sabine" uniqKey="Delannoy S" first="Sabine" last="Delannoy">Sabine Delannoy</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lacher, David W" sort="Lacher, David W" uniqKey="Lacher D" first="David W" last="Lacher">David W. Lacher</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Molecular Biology, Food and Drug Administration, Laurel, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos, Luis Fernando" sort="Dos Santos, Luis Fernando" uniqKey="Dos Santos L" first="Luis Fernando" last="Dos Santos">Luis Fernando Dos Santos</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beutin, Lothar" sort="Beutin, Lothar" uniqKey="Beutin L" first="Lothar" last="Beutin">Lothar Beutin</name>
<affiliation wicri:level="3"><nlm:affiliation>National Reference Laboratory for Escherichia coli, Federal Institute for Risk Assessment, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Reference Laboratory for Escherichia coli, Federal Institute for Risk Assessment, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fach, Patrick" sort="Fach, Patrick" uniqKey="Fach P" first="Patrick" last="Fach">Patrick Fach</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratory for Food Safety, French Agency for Food, Environmental, and Occupational Health and Safety, Maisons-Alfort</wicri:regionArea>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
<wicri:noRegion>Maisons-Alfort</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivas, Marta" sort="Rivas, Marta" uniqKey="Rivas M" first="Marta" last="Rivas">Marta Rivas</name>
<affiliation wicri:level="1"><nlm:affiliation>Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Buenos Aires, Argentina.</nlm:affiliation>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Servicio Fisiopatogenia, Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán," Buenos Aires</wicri:regionArea>
<wicri:noRegion>" Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartland, Elizabeth L" sort="Hartland, Elizabeth L" uniqKey="Hartland E" first="Elizabeth L" last="Hartland">Elizabeth L. Hartland</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paton, Adrienne W" sort="Paton, Adrienne W" uniqKey="Paton A" first="Adrienne W" last="Paton">Adrienne W. Paton</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guth, Beatriz E C" sort="Guth, Beatriz E C" uniqKey="Guth B" first="Beatriz E C" last="Guth">Beatriz E C. Guth</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo, Brazil.</nlm:affiliation>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Microbiology, Immunology and Parasitology, Universidade Federal de São Paulo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Applied and environmental microbiology</title>
<idno type="eISSN">1098-5336</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cattle</term>
<term>Dogs</term>
<term>Environmental Microbiology</term>
<term>Escherichia coli Infections (microbiology)</term>
<term>Escherichia coli Proteins (genetics)</term>
<term>Feces (microbiology)</term>
<term>Food Microbiology</term>
<term>Genetic Variation</term>
<term>Goats</term>
<term>Humans</term>
<term>Meat (microbiology)</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Shiga Toxin (metabolism)</term>
<term>Shiga-Toxigenic Escherichia coli (classification)</term>
<term>Shiga-Toxigenic Escherichia coli (genetics)</term>
<term>Shiga-Toxigenic Escherichia coli (isolation & purification)</term>
<term>Shiga-Toxigenic Escherichia coli (metabolism)</term>
<term>Virulence Factors (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Bovins</term>
<term>Capra</term>
<term>Chiens</term>
<term>Données de séquences moléculaires</term>
<term>Escherichia coli producteur de Shiga-toxine ()</term>
<term>Escherichia coli producteur de Shiga-toxine (génétique)</term>
<term>Escherichia coli producteur de Shiga-toxine (isolement et purification)</term>
<term>Escherichia coli producteur de Shiga-toxine (métabolisme)</term>
<term>Facteurs de virulence (génétique)</term>
<term>Fèces (microbiologie)</term>
<term>Humains</term>
<term>Infections à Escherichia coli (microbiologie)</term>
<term>Microbiologie alimentaire</term>
<term>Microbiologie de l'environnement</term>
<term>Phylogénie</term>
<term>Protéines Escherichia coli (génétique)</term>
<term>Shiga-toxine (métabolisme)</term>
<term>Variation génétique</term>
<term>Viande (microbiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Escherichia coli Proteins</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Shiga Toxin</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Shiga-Toxigenic Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Shiga-Toxigenic Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Escherichia coli producteur de Shiga-toxine</term>
<term>Facteurs de virulence</term>
<term>Protéines Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Shiga-Toxigenic Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Escherichia coli producteur de Shiga-toxine</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Shiga-Toxigenic Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Fèces</term>
<term>Infections à Escherichia coli</term>
<term>Viande</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Escherichia coli Infections</term>
<term>Feces</term>
<term>Meat</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Escherichia coli producteur de Shiga-toxine</term>
<term>Shiga-toxine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cattle</term>
<term>Dogs</term>
<term>Environmental Microbiology</term>
<term>Food Microbiology</term>
<term>Genetic Variation</term>
<term>Goats</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Bovins</term>
<term>Capra</term>
<term>Chiens</term>
<term>Données de séquences moléculaires</term>
<term>Escherichia coli producteur de Shiga-toxine</term>
<term>Humains</term>
<term>Microbiologie alimentaire</term>
<term>Microbiologie de l'environnement</term>
<term>Phylogénie</term>
<term>Variation génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains.</div>
</front>
</TEI>
</pubmed>
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Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources

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