Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect.
Identifieur interne : 001A54 ( Ncbi/Merge ); précédent : 001A53; suivant : 001A55Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect.
Auteurs : D M Johnstone [Australie] ; N. El Massri [Australie] ; C. Moro [France] ; S. Spana [Australie] ; X S Wang [Australie] ; N. Torres [France] ; C. Chabrol [France] ; X. De Jaeger [France] ; F. Reinhart [France] ; S. Purushothuman [Australie] ; A-L Benabid [France] ; J. Stone [Australie] ; J. Mitrofanis [Australie]Source :
- Neuroscience [ 1873-7544 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Astrocytes (métabolisme), Microglie (métabolisme), Modèles animaux de maladie humaine, Mâle, Neuroprotecteurs, Numération cellulaire, Pars compacta (métabolisme), Photothérapie, Souris, Souris de lignée BALB C, Syndromes parkinsoniens (), Syndromes parkinsoniens (métabolisme), Tyrosine 3-monooxygenase (métabolisme).
- MESH :
English descriptors
- KwdEn :
- Animals, Astrocytes (metabolism), Cell Count, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C, Microglia (metabolism), Neuroprotective Agents, Parkinsonian Disorders (metabolism), Parkinsonian Disorders (therapy), Pars Compacta (metabolism), Phototherapy, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical : Neuroprotective Agents.
- metabolism : Astrocytes, Microglia, Parkinsonian Disorders, Pars Compacta.
- therapy : Parkinsonian Disorders.
- Animals, Cell Count, Disease Models, Animal, Male, Mice, Mice, Inbred BALB C, Phototherapy.
Abstract
We have previously shown near infrared light (NIr), directed transcranially, mitigates the loss of dopaminergic cells in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice, a model of parkinsonism. These findings complement others suggesting NIr treatment protects against damage from various insults. However one puzzling feature of NIr treatment is that unilateral exposure can lead to a bilateral healing response, suggesting NIr may have 'indirect' protective effects. We investigated whether remote NIr treatment is neuroprotective by administering different MPTP doses (50-, 75-, 100-mg/kg) to mice and treating with 670-nm light directed specifically at either the head or body. Our results show that, despite no direct irradiation of the damaged tissue, remote NIr treatment produces a significant rescue of tyrosine hydroxylase-positive cells in the substantia nigra pars compacta at the milder MPTP dose of 50-mg/kg (∼30% increase vs sham-treated MPTP mice, p<0.05). However this protection did not appear as robust as that achieved by direct irradiation of the head (∼50% increase vs sham-treated MPTP mice, p<0.001). There was no quantifiable protective effect of NIr at higher MPTP doses, irrespective of the delivery mode. Astrocyte and microglia cell numbers in substantia nigra pars compacta were not influenced by either mode of NIr treatment. In summary, the findings suggest that treatment of a remote tissue with NIr is sufficient to induce protection of the brain, reminiscent of the 'abscopal effect' sometimes observed in radiation treatment of metastatic cancer. This discovery has implications for the clinical translation of light-based therapies, providing an improved mode of delivery over transcranial irradiation.
DOI: 10.1016/j.neuroscience.2014.05.023
PubMed: 24857852
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Electronic address: Daniel.Johnstone@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="El Massri, N" sort="El Massri, N" uniqKey="El Massri N" first="N" last="El Massri">N. El Massri</name><affiliation wicri:level="4"><nlm:affiliation>Discipline of Anatomy & Histology, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Anatomy & Histology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Moro, C" sort="Moro, C" uniqKey="Moro C" first="C" last="Moro">C. Moro</name><affiliation wicri:level="3"><nlm:affiliation>CEA, LETI, 38054 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Spana, S" sort="Spana, S" uniqKey="Spana S" first="S" last="Spana">S. Spana</name><affiliation wicri:level="4"><nlm:affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Wang, X S" sort="Wang, X S" uniqKey="Wang X" first="X S" last="Wang">X S Wang</name><affiliation wicri:level="4"><nlm:affiliation>Bosch Mass Spectrometry Facility, Bosch Institute, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bosch Mass Spectrometry Facility, Bosch Institute, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Torres, N" sort="Torres, N" uniqKey="Torres N" first="N" last="Torres">N. Torres</name><affiliation wicri:level="3"><nlm:affiliation>CEA, LETI, 38054 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Chabrol, C" sort="Chabrol, C" uniqKey="Chabrol C" first="C" last="Chabrol">C. Chabrol</name><affiliation wicri:level="3"><nlm:affiliation>CEA, LETI, 38054 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="De Jaeger, X" sort="De Jaeger, X" uniqKey="De Jaeger X" first="X" last="De Jaeger">X. De Jaeger</name><affiliation wicri:level="3"><nlm:affiliation>CEA, LETI, 38054 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Reinhart, F" sort="Reinhart, F" uniqKey="Reinhart F" first="F" last="Reinhart">F. Reinhart</name><affiliation wicri:level="3"><nlm:affiliation>CEA, LETI, 38054 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Purushothuman, S" sort="Purushothuman, S" uniqKey="Purushothuman S" first="S" last="Purushothuman">S. Purushothuman</name><affiliation wicri:level="4"><nlm:affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A-L" last="Benabid">A-L Benabid</name><affiliation wicri:level="3"><nlm:affiliation>CEA, LETI, 38054 Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, 38054 Grenoble</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Stone, J" sort="Stone, J" uniqKey="Stone J" first="J" last="Stone">J. Stone</name><affiliation wicri:level="4"><nlm:affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Mitrofanis, J" sort="Mitrofanis, J" uniqKey="Mitrofanis J" first="J" last="Mitrofanis">J. Mitrofanis</name><affiliation wicri:level="4"><nlm:affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Anatomy & Histology, University of Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Bosch Institute, University of Sydney, Australia; Discipline of Anatomy & Histology, University of Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j">Neuroscience</title><idno type="eISSN">1873-7544</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Astrocytes (metabolism)</term><term>Cell Count</term><term>Disease Models, Animal</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microglia (metabolism)</term><term>Neuroprotective Agents</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (therapy)</term><term>Pars Compacta (metabolism)</term><term>Phototherapy</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Astrocytes (métabolisme)</term><term>Microglie (métabolisme)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Neuroprotecteurs</term><term>Numération cellulaire</term><term>Pars compacta (métabolisme)</term><term>Photothérapie</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndromes parkinsoniens ()</term><term>Syndromes parkinsoniens (métabolisme)</term><term>Tyrosine 3-monooxygenase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Astrocytes</term><term>Microglia</term><term>Parkinsonian Disorders</term><term>Pars Compacta</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Astrocytes</term><term>Microglie</term><term>Pars compacta</term><term>Syndromes parkinsoniens</term><term>Tyrosine 3-monooxygenase</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Count</term><term>Disease Models, Animal</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Phototherapy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Neuroprotecteurs</term><term>Numération cellulaire</term><term>Photothérapie</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndromes parkinsoniens</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have previously shown near infrared light (NIr), directed transcranially, mitigates the loss of dopaminergic cells in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice, a model of parkinsonism. These findings complement others suggesting NIr treatment protects against damage from various insults. However one puzzling feature of NIr treatment is that unilateral exposure can lead to a bilateral healing response, suggesting NIr may have 'indirect' protective effects. We investigated whether remote NIr treatment is neuroprotective by administering different MPTP doses (50-, 75-, 100-mg/kg) to mice and treating with 670-nm light directed specifically at either the head or body. Our results show that, despite no direct irradiation of the damaged tissue, remote NIr treatment produces a significant rescue of tyrosine hydroxylase-positive cells in the substantia nigra pars compacta at the milder MPTP dose of 50-mg/kg (∼30% increase vs sham-treated MPTP mice, p<0.05). However this protection did not appear as robust as that achieved by direct irradiation of the head (∼50% increase vs sham-treated MPTP mice, p<0.001). There was no quantifiable protective effect of NIr at higher MPTP doses, irrespective of the delivery mode. Astrocyte and microglia cell numbers in substantia nigra pars compacta were not influenced by either mode of NIr treatment. In summary, the findings suggest that treatment of a remote tissue with NIr is sufficient to induce protection of the brain, reminiscent of the 'abscopal effect' sometimes observed in radiation treatment of metastatic cancer. This discovery has implications for the clinical translation of light-based therapies, providing an improved mode of delivery over transcranial irradiation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24857852</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>14</Day></DateCreated><DateCompleted><Year>2015</Year><Month>10</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>07</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-7544</ISSN><JournalIssue CitedMedium="Internet"><Volume>274</Volume><PubDate><Year>2014</Year><Month>Aug</Month><Day>22</Day></PubDate></JournalIssue><Title>Neuroscience</Title><ISOAbbreviation>Neuroscience</ISOAbbreviation></Journal><ArticleTitle>Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism - an abscopal neuroprotective effect.</ArticleTitle><Pagination><MedlinePgn>93-101</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuroscience.2014.05.023</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0306-4522(14)00415-1</ELocationID><Abstract><AbstractText>We have previously shown near infrared light (NIr), directed transcranially, mitigates the loss of dopaminergic cells in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice, a model of parkinsonism. These findings complement others suggesting NIr treatment protects against damage from various insults. However one puzzling feature of NIr treatment is that unilateral exposure can lead to a bilateral healing response, suggesting NIr may have 'indirect' protective effects. We investigated whether remote NIr treatment is neuroprotective by administering different MPTP doses (50-, 75-, 100-mg/kg) to mice and treating with 670-nm light directed specifically at either the head or body. Our results show that, despite no direct irradiation of the damaged tissue, remote NIr treatment produces a significant rescue of tyrosine hydroxylase-positive cells in the substantia nigra pars compacta at the milder MPTP dose of 50-mg/kg (∼30% increase vs sham-treated MPTP mice, p<0.05). However this protection did not appear as robust as that achieved by direct irradiation of the head (∼50% increase vs sham-treated MPTP mice, p<0.001). There was no quantifiable protective effect of NIr at higher MPTP doses, irrespective of the delivery mode. Astrocyte and microglia cell numbers in substantia nigra pars compacta were not influenced by either mode of NIr treatment. In summary, the findings suggest that treatment of a remote tissue with NIr is sufficient to induce protection of the brain, reminiscent of the 'abscopal effect' sometimes observed in radiation treatment of metastatic cancer. This discovery has implications for the clinical translation of light-based therapies, providing an improved mode of delivery over transcranial irradiation.</AbstractText><CopyrightInformation>Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Johnstone</LastName><ForeName>D M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia. Electronic address: Daniel.Johnstone@sydney.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>el Massri</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Discipline of Anatomy & Histology, University of Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moro</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CEA, LETI, 38054 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spana</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>X S</ForeName><Initials>XS</Initials><AffiliationInfo><Affiliation>Bosch Mass Spectrometry Facility, Bosch Institute, University of Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>CEA, LETI, 38054 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabrol</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>CEA, LETI, 38054 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Jaeger</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>CEA, LETI, 38054 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reinhart</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>CEA, LETI, 38054 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purushothuman</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benabid</LastName><ForeName>A-L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>CEA, LETI, 38054 Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stone</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Physiology, University of Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitrofanis</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Bosch Institute, University of Sydney, Australia; Discipline of Anatomy & Histology, University of Sydney, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>05</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neuroscience</MedlineTA><NlmUniqueID>7605074</NlmUniqueID><ISSNLinking>0306-4522</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018696">Neuroprotective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.16.2</RegistryNumber><NameOfSubstance UI="D014446">Tyrosine 3-Monooxygenase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001253" MajorTopicYN="N">Astrocytes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002452" MajorTopicYN="N">Cell Count</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017628" MajorTopicYN="N">Microglia</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018696" MajorTopicYN="Y">Neuroprotective Agents</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D065842" MajorTopicYN="N">Pars Compacta</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010789" MajorTopicYN="Y">Phototherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014446" MajorTopicYN="N">Tyrosine 3-Monooxygenase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">MPTP</Keyword><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword><Keyword MajorTopicYN="N">mouse model</Keyword><Keyword MajorTopicYN="N">near infrared light</Keyword><Keyword MajorTopicYN="N">neuroprotection</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>04</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>05</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>05</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>10</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24857852</ArticleId><ArticleId IdType="pii">S0306-4522(14)00415-1</ArticleId><ArticleId IdType="doi">10.1016/j.neuroscience.2014.05.023</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Johnstone, D M" sort="Johnstone, D M" uniqKey="Johnstone D" first="D M" last="Johnstone">D M Johnstone</name></region><name sortKey="El Massri, N" sort="El Massri, N" uniqKey="El Massri N" first="N" last="El Massri">N. El Massri</name><name sortKey="Mitrofanis, J" sort="Mitrofanis, J" uniqKey="Mitrofanis J" first="J" last="Mitrofanis">J. Mitrofanis</name><name sortKey="Purushothuman, S" sort="Purushothuman, S" uniqKey="Purushothuman S" first="S" last="Purushothuman">S. Purushothuman</name><name sortKey="Spana, S" sort="Spana, S" uniqKey="Spana S" first="S" last="Spana">S. Spana</name><name sortKey="Stone, J" sort="Stone, J" uniqKey="Stone J" first="J" last="Stone">J. Stone</name><name sortKey="Wang, X S" sort="Wang, X S" uniqKey="Wang X" first="X S" last="Wang">X S Wang</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moro, C" sort="Moro, C" uniqKey="Moro C" first="C" last="Moro">C. Moro</name></region><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A-L" last="Benabid">A-L Benabid</name><name sortKey="Chabrol, C" sort="Chabrol, C" uniqKey="Chabrol C" first="C" last="Chabrol">C. Chabrol</name><name sortKey="De Jaeger, X" sort="De Jaeger, X" uniqKey="De Jaeger X" first="X" last="De Jaeger">X. De Jaeger</name><name sortKey="Reinhart, F" sort="Reinhart, F" uniqKey="Reinhart F" first="F" last="Reinhart">F. Reinhart</name><name sortKey="Torres, N" sort="Torres, N" uniqKey="Torres N" first="N" last="Torres">N. Torres</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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