DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
Identifieur interne : 000B99 ( Ncbi/Merge ); précédent : 000B98; suivant : 000C00DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice
Auteurs : Katrina L. Randall ; Stephanie S.-Y. Chan ; Cindy S. Ma ; Ivan Fung ; Yan Mei ; Mehmet Yabas ; Andy Tan ; Peter D. Arkwright ; Wafaa Al Suwairi ; Saul Oswaldo Lugo Reyes ; Marco A. Yamazaki-Nakashimada ; Maria De La Luz Garcia-Cruz ; Joanne M. Smart ; Capucine Picard ; Satoshi Okada ; Emmanuelle Jouanguy ; Jean-Laurent Casanova ; Teresa Lambe ; Richard J. Cornall ; Sarah Russell ; Jane Oliaro ; Stuart G. Tangye ; Edward M. Bertram ; Christopher C. GoodnowSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2011.
Abstract
As shown by analysis of mice and humans bearing DOCK8-inactivating mutations, DOCK8 plays a cell-autonomous role in survival of naive CD8 T cells, LFA-1 polarization toward the immune synapse, and CD8 T cell memory and recall responses following viral infection.
Url:
DOI: 10.1084/jem.20110345
PubMed: 22006977
PubMed Central: 3201196
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PMC:3201196Le document en format XML
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<author><name sortKey="Randall, Katrina L" sort="Randall, Katrina L" uniqKey="Randall K" first="Katrina L." last="Randall">Katrina L. Randall</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
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<affiliation><nlm:aff id="aff1"><institution>Australian National University Medical School, Australian National University, Canberra, Australian Capital Territory 0200, Australia</institution>
</nlm:aff>
</affiliation>
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<author><name sortKey="Chan, Stephanie S Y" sort="Chan, Stephanie S Y" uniqKey="Chan S" first="Stephanie S.-Y." last="Chan">Stephanie S.-Y. Chan</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
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<author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name>
<affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales 2052, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fung, Ivan" sort="Fung, Ivan" uniqKey="Fung I" first="Ivan" last="Fung">Ivan Fung</name>
<affiliation><nlm:aff id="aff4"><institution>Cancer Immunology Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5"><institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mei, Yan" sort="Mei, Yan" uniqKey="Mei Y" first="Yan" last="Mei">Yan Mei</name>
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</nlm:aff>
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<author><name sortKey="Yabas, Mehmet" sort="Yabas, Mehmet" uniqKey="Yabas M" first="Mehmet" last="Yabas">Mehmet Yabas</name>
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<author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name>
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<author><name sortKey="Al Suwairi, Wafaa" sort="Al Suwairi, Wafaa" uniqKey="Al Suwairi W" first="Wafaa" last="Al Suwairi">Wafaa Al Suwairi</name>
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<author><name sortKey="Lugo Reyes, Saul Oswaldo" sort="Lugo Reyes, Saul Oswaldo" uniqKey="Lugo Reyes S" first="Saul Oswaldo" last="Lugo Reyes">Saul Oswaldo Lugo Reyes</name>
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<author><name sortKey="Yamazaki Nakashimada, Marco A" sort="Yamazaki Nakashimada, Marco A" uniqKey="Yamazaki Nakashimada M" first="Marco A." last="Yamazaki-Nakashimada">Marco A. Yamazaki-Nakashimada</name>
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<author><name sortKey="De La Luz Garcia Cruz, Maria" sort="De La Luz Garcia Cruz, Maria" uniqKey="De La Luz Garcia Cruz M" first="Maria" last="De La Luz Garcia-Cruz">Maria De La Luz Garcia-Cruz</name>
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<author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name>
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<author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
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<affiliation><nlm:aff id="aff12"><institution>Necker Medicine Faculty, Sorbonne Paris Cité, Paris Descartes University, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, National Institute of Health and Medical Research, U980, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
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<author><name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name>
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</nlm:aff>
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<author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
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</nlm:aff>
</affiliation>
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</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff14"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution>
</nlm:aff>
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<author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
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</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff14"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution>
</nlm:aff>
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<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
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</nlm:aff>
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<author><name sortKey="Cornall, Richard J" sort="Cornall, Richard J" uniqKey="Cornall R" first="Richard J." last="Cornall">Richard J. Cornall</name>
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</nlm:aff>
</affiliation>
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<author><name sortKey="Russell, Sarah" sort="Russell, Sarah" uniqKey="Russell S" first="Sarah" last="Russell">Sarah Russell</name>
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</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5"><institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff16"><institution>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia</institution>
</nlm:aff>
</affiliation>
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<author><name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<affiliation><nlm:aff id="aff4"><institution>Cancer Immunology Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5"><institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name>
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</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales 2052, Australia</institution>
</nlm:aff>
</affiliation>
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<author><name sortKey="Bertram, Edward M" sort="Bertram, Edward M" uniqKey="Bertram E" first="Edward M." last="Bertram">Edward M. Bertram</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
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<author><name sortKey="Goodnow, Christopher C" sort="Goodnow, Christopher C" uniqKey="Goodnow C" first="Christopher C." last="Goodnow">Christopher C. Goodnow</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice</title>
<author><name sortKey="Randall, Katrina L" sort="Randall, Katrina L" uniqKey="Randall K" first="Katrina L." last="Randall">Katrina L. Randall</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff1"><institution>Australian National University Medical School, Australian National University, Canberra, Australian Capital Territory 0200, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Stephanie S Y" sort="Chan, Stephanie S Y" uniqKey="Chan S" first="Stephanie S.-Y." last="Chan">Stephanie S.-Y. Chan</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name>
<affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales 2052, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fung, Ivan" sort="Fung, Ivan" uniqKey="Fung I" first="Ivan" last="Fung">Ivan Fung</name>
<affiliation><nlm:aff id="aff4"><institution>Cancer Immunology Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5"><institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mei, Yan" sort="Mei, Yan" uniqKey="Mei Y" first="Yan" last="Mei">Yan Mei</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yabas, Mehmet" sort="Yabas, Mehmet" uniqKey="Yabas M" first="Mehmet" last="Yabas">Mehmet Yabas</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tan, Andy" sort="Tan, Andy" uniqKey="Tan A" first="Andy" last="Tan">Andy Tan</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name>
<affiliation><nlm:aff id="aff6"><institution>Royal Manchester Children’s Hospital, The University of Manchester, Manchester M13 9WL, England, UK</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Al Suwairi, Wafaa" sort="Al Suwairi, Wafaa" uniqKey="Al Suwairi W" first="Wafaa" last="Al Suwairi">Wafaa Al Suwairi</name>
<affiliation><nlm:aff id="aff7"><institution>King Abdullah International Medical Research Center, King Abdul-Aziz Medical Center, Riyadh 11426, Saudi Arabia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lugo Reyes, Saul Oswaldo" sort="Lugo Reyes, Saul Oswaldo" uniqKey="Lugo Reyes S" first="Saul Oswaldo" last="Lugo Reyes">Saul Oswaldo Lugo Reyes</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff8"><institution>Immunodeficiencies Research Unit</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yamazaki Nakashimada, Marco A" sort="Yamazaki Nakashimada, Marco A" uniqKey="Yamazaki Nakashimada M" first="Marco A." last="Yamazaki-Nakashimada">Marco A. Yamazaki-Nakashimada</name>
<affiliation><nlm:aff id="aff8"><institution>Clinical Immunology Department, National Institute of Pediatrics, Mexico City 04530, Mexico</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De La Luz Garcia Cruz, Maria" sort="De La Luz Garcia Cruz, Maria" uniqKey="De La Luz Garcia Cruz M" first="Maria" last="De La Luz Garcia-Cruz">Maria De La Luz Garcia-Cruz</name>
<affiliation><nlm:aff id="aff9"><institution>Allergy and Clinical Immunology Department, National Institute of Respiratory Diseases, Mexico City 14080, Mexico</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name>
<affiliation><nlm:aff id="aff10"><institution>Allergy and Immunology Department, Royal Children’s Hospital, Parkville, Victoria 3052, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
<affiliation><nlm:aff id="aff11"><institution>Study Center of Primary Immunodeficiencies, Necker Hospital, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff12"><institution>Necker Medicine Faculty, Sorbonne Paris Cité, Paris Descartes University, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, National Institute of Health and Medical Research, U980, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name>
<affiliation><nlm:aff id="aff14"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
<affiliation><nlm:aff id="aff12"><institution>Necker Medicine Faculty, Sorbonne Paris Cité, Paris Descartes University, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, National Institute of Health and Medical Research, U980, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff14"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<affiliation><nlm:aff id="aff12"><institution>Necker Medicine Faculty, Sorbonne Paris Cité, Paris Descartes University, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff13"><institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, National Institute of Health and Medical Research, U980, 75015 Paris, France</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff14"><institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<affiliation><nlm:aff id="aff15"><institution>Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, England, UK</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cornall, Richard J" sort="Cornall, Richard J" uniqKey="Cornall R" first="Richard J." last="Cornall">Richard J. Cornall</name>
<affiliation><nlm:aff id="aff15"><institution>Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, England, UK</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Russell, Sarah" sort="Russell, Sarah" uniqKey="Russell S" first="Sarah" last="Russell">Sarah Russell</name>
<affiliation><nlm:aff id="aff4"><institution>Cancer Immunology Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5"><institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff16"><institution>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<affiliation><nlm:aff id="aff4"><institution>Cancer Immunology Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5"><institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name>
<affiliation><nlm:aff id="aff2"><institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia</institution>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales 2052, Australia</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bertram, Edward M" sort="Bertram, Edward M" uniqKey="Bertram E" first="Edward M." last="Bertram">Edward M. Bertram</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Goodnow, Christopher C" sort="Goodnow, Christopher C" uniqKey="Goodnow C" first="Christopher C." last="Goodnow">Christopher C. Goodnow</name>
<affiliation><nlm:aff wicri:cut=" and" id="aff1"><institution>Department of Immunology, The John Curtin School of Medical Research</institution>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Experimental Medicine</title>
<idno type="ISSN">0022-1007</idno>
<idno type="eISSN">1540-9538</idno>
<imprint><date when="2011">2011</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p>As shown by analysis of mice and humans bearing DOCK8-inactivating mutations, DOCK8 plays a cell-autonomous role in survival of naive CD8 T cells, LFA-1 polarization toward the immune synapse, and CD8 T cell memory and recall responses following viral infection.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Med</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Exp. Med</journal-id>
<journal-id journal-id-type="hwp">jem</journal-id>
<journal-title-group><journal-title>The Journal of Experimental Medicine</journal-title>
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<issn pub-type="ppub">0022-1007</issn>
<issn pub-type="epub">1540-9538</issn>
<publisher><publisher-name>The Rockefeller University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22006977</article-id>
<article-id pub-id-type="pmc">3201196</article-id>
<article-id pub-id-type="publisher-id">20110345</article-id>
<article-id pub-id-type="doi">10.1084/jem.20110345</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice</article-title>
<alt-title alt-title-type="short">DOCK8 deficiency cripples CD8 T cells</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Randall</surname>
<given-names>Katrina L.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff1">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chan</surname>
<given-names>Stephanie S.-Y.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ma</surname>
<given-names>Cindy S.</given-names>
</name>
<xref ref-type="aff" rid="aff2">3</xref>
<xref ref-type="aff" rid="aff3">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fung</surname>
<given-names>Ivan</given-names>
</name>
<xref ref-type="aff" rid="aff4">5</xref>
<xref ref-type="aff" rid="aff5">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mei</surname>
<given-names>Yan</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yabas</surname>
<given-names>Mehmet</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tan</surname>
<given-names>Andy</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arkwright</surname>
<given-names>Peter D.</given-names>
</name>
<xref ref-type="aff" rid="aff6">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Al Suwairi</surname>
<given-names>Wafaa</given-names>
</name>
<xref ref-type="aff" rid="aff7">8</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lugo Reyes</surname>
<given-names>Saul Oswaldo</given-names>
</name>
<xref ref-type="aff" rid="aff8">9</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yamazaki-Nakashimada</surname>
<given-names>Marco A.</given-names>
</name>
<xref ref-type="aff" rid="aff8">10</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de la Luz Garcia-Cruz</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="aff9">11</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smart</surname>
<given-names>Joanne M.</given-names>
</name>
<xref ref-type="aff" rid="aff10">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Picard</surname>
<given-names>Capucine</given-names>
</name>
<xref ref-type="aff" rid="aff11">13</xref>
<xref ref-type="aff" rid="aff12">14</xref>
<xref ref-type="aff" rid="aff13">15</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Okada</surname>
<given-names>Satoshi</given-names>
</name>
<xref ref-type="aff" rid="aff14">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jouanguy</surname>
<given-names>Emmanuelle</given-names>
</name>
<xref ref-type="aff" rid="aff12">14</xref>
<xref ref-type="aff" rid="aff13">15</xref>
<xref ref-type="aff" rid="aff14">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Casanova</surname>
<given-names>Jean-Laurent</given-names>
</name>
<xref ref-type="aff" rid="aff12">14</xref>
<xref ref-type="aff" rid="aff13">15</xref>
<xref ref-type="aff" rid="aff14">16</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lambe</surname>
<given-names>Teresa</given-names>
</name>
<xref ref-type="aff" rid="aff15">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cornall</surname>
<given-names>Richard J.</given-names>
</name>
<xref ref-type="aff" rid="aff15">17</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Russell</surname>
<given-names>Sarah</given-names>
</name>
<xref ref-type="aff" rid="aff4">5</xref>
<xref ref-type="aff" rid="aff5">6</xref>
<xref ref-type="aff" rid="aff16">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oliaro</surname>
<given-names>Jane</given-names>
</name>
<xref ref-type="aff" rid="aff4">5</xref>
<xref ref-type="aff" rid="aff5">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tangye</surname>
<given-names>Stuart G.</given-names>
</name>
<xref ref-type="aff" rid="aff2">3</xref>
<xref ref-type="aff" rid="aff3">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bertram</surname>
<given-names>Edward M.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Goodnow</surname>
<given-names>Christopher C.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<institution>Department of Immunology, The John Curtin School of Medical Research</institution>
and<label>2</label>
<institution>Australian National University Medical School, Australian National University, Canberra, Australian Capital Territory 0200, Australia</institution>
</aff>
<aff id="aff2"><label>3</label>
<institution>Immunology Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia</institution>
</aff>
<aff id="aff3"><label>4</label>
<institution>St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Kensington, New South Wales 2052, Australia</institution>
</aff>
<aff id="aff4"><label>5</label>
<institution>Cancer Immunology Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia</institution>
</aff>
<aff id="aff5"><label>6</label>
<institution>Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia</institution>
</aff>
<aff id="aff6"><label>7</label>
<institution>Royal Manchester Children’s Hospital, The University of Manchester, Manchester M13 9WL, England, UK</institution>
</aff>
<aff id="aff7"><label>8</label>
<institution>King Abdullah International Medical Research Center, King Abdul-Aziz Medical Center, Riyadh 11426, Saudi Arabia</institution>
</aff>
<aff id="aff8"><label>9</label>
<institution>Immunodeficiencies Research Unit</institution>
and<label>10</label>
<institution>Clinical Immunology Department, National Institute of Pediatrics, Mexico City 04530, Mexico</institution>
</aff>
<aff id="aff9"><label>11</label>
<institution>Allergy and Clinical Immunology Department, National Institute of Respiratory Diseases, Mexico City 14080, Mexico</institution>
</aff>
<aff id="aff10"><label>12</label>
<institution>Allergy and Immunology Department, Royal Children’s Hospital, Parkville, Victoria 3052, Australia</institution>
</aff>
<aff id="aff11"><label>13</label>
<institution>Study Center of Primary Immunodeficiencies, Necker Hospital, 75015 Paris, France</institution>
</aff>
<aff id="aff12"><label>14</label>
<institution>Necker Medicine Faculty, Sorbonne Paris Cité, Paris Descartes University, 75015 Paris, France</institution>
</aff>
<aff id="aff13"><label>15</label>
<institution>Laboratory of Human Genetics of Infectious Diseases, Necker Branch, National Institute of Health and Medical Research, U980, 75015 Paris, France</institution>
</aff>
<aff id="aff14"><label>16</label>
<institution>St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065</institution>
</aff>
<aff id="aff15"><label>17</label>
<institution>Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, England, UK</institution>
</aff>
<aff id="aff16"><label>18</label>
<institution>Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Victoria 3122, Australia</institution>
</aff>
<author-notes><corresp>CORRESPONDENCE Christopher C. Goodnow: <email>chris.goodnow@anu.edu.au</email>
</corresp>
<fn><p>K.L. Randall, S.S.-Y. Chan, C.S. Ma, and I. Fung contributed equally to this paper.</p>
</fn>
<fn><p>J. Oliaro, S.G. Tangye, E.M. Bertram, and C.C. Goodnow contributed equally to this paper.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>24</day>
<month>10</month>
<year>2011</year>
</pub-date>
<volume>208</volume>
<issue>11</issue>
<fpage>2305</fpage>
<lpage>2320</lpage>
<history><date date-type="received"><day>14</day>
<month>2</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>15</day>
<month>9</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© 2011 Randall et al.</copyright-statement>
<copyright-year>2011</copyright-year>
<license license-type="openaccess"><license-p>This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see <ext-link ext-link-type="uri" xlink:href="http://www.rupress.org/terms">http://www.rupress.org/terms</ext-link>
). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/">http://creativecommons.org/licenses/by-nc-sa/3.0/</ext-link>
).</license-p>
</license>
</permissions>
<self-uri xlink:role="icon" xlink:type="simple" xlink:href="JEM_20110345_thumb.gif"></self-uri>
<abstract abstract-type="precis"><p>As shown by analysis of mice and humans bearing DOCK8-inactivating mutations, DOCK8 plays a cell-autonomous role in survival of naive CD8 T cells, LFA-1 polarization toward the immune synapse, and CD8 T cell memory and recall responses following viral infection.</p>
</abstract>
<abstract><p>In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 T cells in both species, and in DOCK8-deficient humans, most CD8 T cells displayed an exhausted CD45RA<sup>+</sup>
CCR7<sup>−</sup>
phenotype. Analyses in mice revealed the CD8 T cell abnormalities to be cell autonomous and primarily postthymic. DOCK8 mutant naive CD8 T cells had a shorter lifespan and, upon encounter with antigen on dendritic cells, exhibited poor LFA-1 synaptic polarization and a delay in the first cell division. Although DOCK8 mutant T cells underwent near-normal primary clonal expansion after primary infection with recombinant influenza virus in vivo, they showed greatly reduced memory cell persistence and recall. These findings highlight a key role for DOCK8 in the survival and function of human and mouse CD8 T cells.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Al Suwairi, Wafaa" sort="Al Suwairi, Wafaa" uniqKey="Al Suwairi W" first="Wafaa" last="Al Suwairi">Wafaa Al Suwairi</name>
<name sortKey="Arkwright, Peter D" sort="Arkwright, Peter D" uniqKey="Arkwright P" first="Peter D." last="Arkwright">Peter D. Arkwright</name>
<name sortKey="Bertram, Edward M" sort="Bertram, Edward M" uniqKey="Bertram E" first="Edward M." last="Bertram">Edward M. Bertram</name>
<name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name>
<name sortKey="Chan, Stephanie S Y" sort="Chan, Stephanie S Y" uniqKey="Chan S" first="Stephanie S.-Y." last="Chan">Stephanie S.-Y. Chan</name>
<name sortKey="Cornall, Richard J" sort="Cornall, Richard J" uniqKey="Cornall R" first="Richard J." last="Cornall">Richard J. Cornall</name>
<name sortKey="De La Luz Garcia Cruz, Maria" sort="De La Luz Garcia Cruz, Maria" uniqKey="De La Luz Garcia Cruz M" first="Maria" last="De La Luz Garcia-Cruz">Maria De La Luz Garcia-Cruz</name>
<name sortKey="Fung, Ivan" sort="Fung, Ivan" uniqKey="Fung I" first="Ivan" last="Fung">Ivan Fung</name>
<name sortKey="Goodnow, Christopher C" sort="Goodnow, Christopher C" uniqKey="Goodnow C" first="Christopher C." last="Goodnow">Christopher C. Goodnow</name>
<name sortKey="Jouanguy, Emmanuelle" sort="Jouanguy, Emmanuelle" uniqKey="Jouanguy E" first="Emmanuelle" last="Jouanguy">Emmanuelle Jouanguy</name>
<name sortKey="Lambe, Teresa" sort="Lambe, Teresa" uniqKey="Lambe T" first="Teresa" last="Lambe">Teresa Lambe</name>
<name sortKey="Lugo Reyes, Saul Oswaldo" sort="Lugo Reyes, Saul Oswaldo" uniqKey="Lugo Reyes S" first="Saul Oswaldo" last="Lugo Reyes">Saul Oswaldo Lugo Reyes</name>
<name sortKey="Ma, Cindy S" sort="Ma, Cindy S" uniqKey="Ma C" first="Cindy S." last="Ma">Cindy S. Ma</name>
<name sortKey="Mei, Yan" sort="Mei, Yan" uniqKey="Mei Y" first="Yan" last="Mei">Yan Mei</name>
<name sortKey="Okada, Satoshi" sort="Okada, Satoshi" uniqKey="Okada S" first="Satoshi" last="Okada">Satoshi Okada</name>
<name sortKey="Oliaro, Jane" sort="Oliaro, Jane" uniqKey="Oliaro J" first="Jane" last="Oliaro">Jane Oliaro</name>
<name sortKey="Picard, Capucine" sort="Picard, Capucine" uniqKey="Picard C" first="Capucine" last="Picard">Capucine Picard</name>
<name sortKey="Randall, Katrina L" sort="Randall, Katrina L" uniqKey="Randall K" first="Katrina L." last="Randall">Katrina L. Randall</name>
<name sortKey="Russell, Sarah" sort="Russell, Sarah" uniqKey="Russell S" first="Sarah" last="Russell">Sarah Russell</name>
<name sortKey="Smart, Joanne M" sort="Smart, Joanne M" uniqKey="Smart J" first="Joanne M." last="Smart">Joanne M. Smart</name>
<name sortKey="Tan, Andy" sort="Tan, Andy" uniqKey="Tan A" first="Andy" last="Tan">Andy Tan</name>
<name sortKey="Tangye, Stuart G" sort="Tangye, Stuart G" uniqKey="Tangye S" first="Stuart G." last="Tangye">Stuart G. Tangye</name>
<name sortKey="Yabas, Mehmet" sort="Yabas, Mehmet" uniqKey="Yabas M" first="Mehmet" last="Yabas">Mehmet Yabas</name>
<name sortKey="Yamazaki Nakashimada, Marco A" sort="Yamazaki Nakashimada, Marco A" uniqKey="Yamazaki Nakashimada M" first="Marco A." last="Yamazaki-Nakashimada">Marco A. Yamazaki-Nakashimada</name>
</noCountry>
</tree>
</affiliations>
</record>
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