Bevacizumab with or after chemotherapy for platinum-resistant recurrent ovarian cancer: exploratory analyses of the AURELIA trial.
Identifieur interne : 004776 ( Ncbi/Curation ); précédent : 004775; suivant : 004777Bevacizumab with or after chemotherapy for platinum-resistant recurrent ovarian cancer: exploratory analyses of the AURELIA trial.
Auteurs : A. Bamias [Grèce] ; E. Gibbs [Australie] ; C. Khoon Lee [Australie] ; L. Davies [Australie] ; M. Dimopoulos [Grèce] ; F. Zagouri [Grèce] ; A-S Veillard [Australie] ; J. Kosse [Allemagne] ; A. Santaballa [Espagne] ; M R Mirza [Danemark] ; G. Tabaro [Italie] ; I. Vergote [Belgique] ; H. Bloemendal [Pays-Bas] ; M. Lykka [Grèce] ; A. Floquet ; V. Gebski [Australie] ; E. Pujade-Lauraine [France]Source :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.
Abstract
In the open-label randomized phase III AURELIA trial, adding bevacizumab to chemotherapy for platinum-resistant ovarian cancer (PROC) significantly improved progression-free survival and response rate versus chemotherapy alone, but not overall survival (OS). We explored the effect of bevacizumab use after disease progression (PD) in patients randomized to chemotherapy alone.
DOI: 10.1093/annonc/mdx228
PubMed: 28481967
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A. Floquet<affiliation><nlm:affiliation>GINECO and Medical Oncology and Genetics Department, Institut Bergonié, Bordeaux.</nlm:affiliation><wicri:noCountry code="subField">Bordeaux</wicri:noCountry></affiliation>Le document en format XML
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Bamias</name><affiliation wicri:level="3"><nlm:affiliation>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Gibbs, E" sort="Gibbs, E" uniqKey="Gibbs E" first="E" last="Gibbs">E. 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Khoon Lee</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Davies, L" sort="Davies, L" uniqKey="Davies L" first="L" last="Davies">L. Davies</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Dimopoulos, M" sort="Dimopoulos, M" uniqKey="Dimopoulos M" first="M" last="Dimopoulos">M. Dimopoulos</name><affiliation wicri:level="3"><nlm:affiliation>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Zagouri, F" sort="Zagouri, F" uniqKey="Zagouri F" first="F" last="Zagouri">F. Zagouri</name><affiliation wicri:level="3"><nlm:affiliation>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Veillard, A S" sort="Veillard, A S" uniqKey="Veillard A" first="A-S" last="Veillard">A-S Veillard</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kosse, J" sort="Kosse, J" uniqKey="Kosse J" first="J" last="Kosse">J. Kosse</name><affiliation wicri:level="1"><nlm:affiliation>AGO and Department of Gynaecology, Sana Klinikum Offenbach, Offenbach, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>AGO and Department of Gynaecology, Sana Klinikum Offenbach, Offenbach</wicri:regionArea><wicri:noRegion>Offenbach</wicri:noRegion><wicri:noRegion>Offenbach</wicri:noRegion><wicri:noRegion>Offenbach</wicri:noRegion></affiliation></author><author><name sortKey="Santaballa, A" sort="Santaballa, A" uniqKey="Santaballa A" first="A" last="Santaballa">A. Santaballa</name><affiliation wicri:level="1"><nlm:affiliation>GEICO and Medical Oncology Department, University Hospital and Polytechnic, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>GEICO and Medical Oncology Department, University Hospital and Polytechnic, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Mirza, M R" sort="Mirza, M R" uniqKey="Mirza M" first="M R" last="Mirza">M R Mirza</name><affiliation wicri:level="3"><nlm:affiliation>NSGO and Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>NSGO and Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Tabaro, G" sort="Tabaro, G" uniqKey="Tabaro G" first="G" last="Tabaro">G. Tabaro</name><affiliation wicri:level="1"><nlm:affiliation>MITO and USCC/Dir. Scientifica, Centro di Riferimento Oncologico, CRO-IRCCS, Aviano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>MITO and USCC/Dir. Scientifica, Centro di Riferimento Oncologico, CRO-IRCCS, Aviano</wicri:regionArea><wicri:noRegion>Aviano</wicri:noRegion></affiliation></author><author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name><affiliation wicri:level="1"><nlm:affiliation>BGOG and Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>BGOG and Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Bloemendal, H" sort="Bloemendal, H" uniqKey="Bloemendal H" first="H" last="Bloemendal">H. Bloemendal</name><affiliation wicri:level="1"><nlm:affiliation>DGOG and Department of Internal Medicine/Oncology, Meander Medical Center, Amersfoort, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>DGOG and Department of Internal Medicine/Oncology, Meander Medical Center, Amersfoort</wicri:regionArea><wicri:noRegion>Amersfoort</wicri:noRegion></affiliation></author><author><name sortKey="Lykka, M" sort="Lykka, M" uniqKey="Lykka M" first="M" last="Lykka">M. Lykka</name><affiliation wicri:level="3"><nlm:affiliation>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Floquet, A" sort="Floquet, A" uniqKey="Floquet A" first="A" last="Floquet">A. Floquet</name><affiliation><nlm:affiliation>GINECO and Medical Oncology and Genetics Department, Institut Bergonié, Bordeaux.</nlm:affiliation><wicri:noCountry code="subField">Bordeaux</wicri:noCountry></affiliation></author><author><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V" last="Gebski">V. Gebski</name><affiliation wicri:level="4"><nlm:affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Camperdown</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name><affiliation wicri:level="3"><nlm:affiliation>GINECO and Paris Descartes University, AP-HP Central Paris University Hospitals, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>GINECO and Paris Descartes University, AP-HP Central Paris University Hospitals, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the open-label randomized phase III AURELIA trial, adding bevacizumab to chemotherapy for platinum-resistant ovarian cancer (PROC) significantly improved progression-free survival and response rate versus chemotherapy alone, but not overall survival (OS). We explored the effect of bevacizumab use after disease progression (PD) in patients randomized to chemotherapy alone.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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