Bevacizumab with or after chemotherapy for platinum-resistant recurrent ovarian cancer: exploratory analyses of the AURELIA trial.
Identifieur interne : 000744 ( PubMed/Corpus ); précédent : 000743; suivant : 000745Bevacizumab with or after chemotherapy for platinum-resistant recurrent ovarian cancer: exploratory analyses of the AURELIA trial.
Auteurs : A. Bamias ; E. Gibbs ; C. Khoon Lee ; L. Davies ; M. Dimopoulos ; F. Zagouri ; A-S Veillard ; J. Kosse ; A. Santaballa ; M R Mirza ; G. Tabaro ; I. Vergote ; H. Bloemendal ; M. Lykka ; A. Floquet ; V. Gebski ; E. Pujade-LauraineSource :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.
Abstract
In the open-label randomized phase III AURELIA trial, adding bevacizumab to chemotherapy for platinum-resistant ovarian cancer (PROC) significantly improved progression-free survival and response rate versus chemotherapy alone, but not overall survival (OS). We explored the effect of bevacizumab use after disease progression (PD) in patients randomized to chemotherapy alone.
DOI: 10.1093/annonc/mdx228
PubMed: 28481967
Links to Exploration step
pubmed:28481967Le document en format XML
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<author><name sortKey="Mirza, M R" sort="Mirza, M R" uniqKey="Mirza M" first="M R" last="Mirza">M R Mirza</name>
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<author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name>
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<author><name sortKey="Bloemendal, H" sort="Bloemendal, H" uniqKey="Bloemendal H" first="H" last="Bloemendal">H. Bloemendal</name>
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<author><name sortKey="Lykka, M" sort="Lykka, M" uniqKey="Lykka M" first="M" last="Lykka">M. Lykka</name>
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<author><name sortKey="Floquet, A" sort="Floquet, A" uniqKey="Floquet A" first="A" last="Floquet">A. Floquet</name>
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<author><name sortKey="Gebski, V" sort="Gebski, V" uniqKey="Gebski V" first="V" last="Gebski">V. Gebski</name>
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<author><name sortKey="Pujade Lauraine, E" sort="Pujade Lauraine, E" uniqKey="Pujade Lauraine E" first="E" last="Pujade-Lauraine">E. Pujade-Lauraine</name>
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<author><name sortKey="Tabaro, G" sort="Tabaro, G" uniqKey="Tabaro G" first="G" last="Tabaro">G. Tabaro</name>
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<author><name sortKey="Vergote, I" sort="Vergote, I" uniqKey="Vergote I" first="I" last="Vergote">I. Vergote</name>
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<author><name sortKey="Bloemendal, H" sort="Bloemendal, H" uniqKey="Bloemendal H" first="H" last="Bloemendal">H. Bloemendal</name>
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<front><div type="abstract" xml:lang="en">In the open-label randomized phase III AURELIA trial, adding bevacizumab to chemotherapy for platinum-resistant ovarian cancer (PROC) significantly improved progression-free survival and response rate versus chemotherapy alone, but not overall survival (OS). We explored the effect of bevacizumab use after disease progression (PD) in patients randomized to chemotherapy alone.</div>
</front>
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<Issue>8</Issue>
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<Month>Aug</Month>
<Day>01</Day>
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<Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title>
<ISOAbbreviation>Ann. Oncol.</ISOAbbreviation>
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<ArticleTitle>Bevacizumab with or after chemotherapy for platinum-resistant recurrent ovarian cancer: exploratory analyses of the AURELIA trial.</ArticleTitle>
<Pagination><MedlinePgn>1842-1848</MedlinePgn>
</Pagination>
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<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">In the open-label randomized phase III AURELIA trial, adding bevacizumab to chemotherapy for platinum-resistant ovarian cancer (PROC) significantly improved progression-free survival and response rate versus chemotherapy alone, but not overall survival (OS). We explored the effect of bevacizumab use after disease progression (PD) in patients randomized to chemotherapy alone.</AbstractText>
<AbstractText Label="Patients and methods" NlmCategory="UNASSIGNED">In AURELIA, 361 women with PROC were randomized to chemotherapy alone or with bevacizumab. Patients initially randomized to chemotherapy were offered bevacizumab after PD. Post hoc analyses assessed efficacy and safety in three subgroups: chemotherapy alone, chemotherapy followed by bevacizumab after PD, and chemotherapy plus bevacizumab at randomization.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">Of the 182 patients randomized to chemotherapy alone, 72 (40%) received bevacizumab after PD and 110 (60%) never received bevacizumab. There were no significant differences in patient and disease characteristics between these subgroups at baseline or the time of PD. Compared with patients never receiving bevacizumab, the risk of death was significantly reduced in patients receiving bevacizumab either upfront with chemotherapy [hazard ratio (HR) = 0.68, 95% confidence interval (CI) 0.52-0.90] or after PD (HR = 0.60, 95% CI 0.43-0.86). The tolerability of bevacizumab was similar with administration upfront or after PD.</AbstractText>
<AbstractText Label="Conclusions" NlmCategory="UNASSIGNED">Post-PD bevacizumab use may have confounded OS results in AURELIA. In these exploratory analyses of non-randomized subgroups, bevacizumab use, either with chemotherapy or after PD on chemotherapy alone, improved OS compared with no bevacizumab. Combining bevacizumab with chemotherapy at first appearance of platinum resistance maximises the likelihood of patients receiving this active treatment for PROC. ClinicalTrials.gov: NCT00976911.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bamias</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>HECOG and Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Gibbs</LastName>
<ForeName>E</ForeName>
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<AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Khoon Lee</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Davies</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Dimopoulos</LastName>
<ForeName>M</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Zagouri</LastName>
<ForeName>F</ForeName>
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<Author ValidYN="Y"><LastName>Veillard</LastName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Kosse</LastName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Santaballa</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Mirza</LastName>
<ForeName>M R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>NSGO and Department of Oncology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tabaro</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Vergote</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>BGOG and Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, University Hospital Leuven, Leuven, Belgium.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Bloemendal</LastName>
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<ForeName>M</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Floquet</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>GINECO and Medical Oncology and Genetics Department, Institut Bergonié, Bordeaux.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gebski</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>NHMRC Clinical Trials Centre, University of Sydney, Camperdown, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pujade-Lauraine</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>GINECO and Paris Descartes University, AP-HP Central Paris University Hospitals, Paris, France.</Affiliation>
</AffiliationInfo>
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<Keyword MajorTopicYN="N">combination therapy</Keyword>
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