Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine
Identifieur interne : 003D02 ( Ncbi/Curation ); précédent : 003D01; suivant : 003D03Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine
Auteurs : Linda J. Fothergill ; Brid Callaghan ; Leni R. Rivera [Australie] ; Tinamarie Lieu ; Daniel P. Poole ; Hyun-Jung Cho ; David M. Bravo ; John B. Furness [Australie]Source :
- Nutrients [ 2072-6643 ] ; 2016.
Descripteurs français
- KwdFr :
- Acroléine (analogues et dérivés), Acroléine (pharmacologie), Aliments, Animaux, Antagonistes des récepteurs 5-HT3 de la sérotonine (pharmacologie), Calcium (métabolisme), Canaux cationiques TRP (), Canaux cationiques TRP (déficit), Canaux cationiques TRP (génétique), Cellules HEK293, Composés phytochimiques (pharmacologie), Côlon (physiologie), Duodénum (physiologie), Entérocytes (), Entérocytes (métabolisme), Expression des gènes, Humains, Isothiocyanates (pharmacologie), Monoterpènes (pharmacologie), Muqueuse intestinale (), Muqueuse intestinale (physiologie), Mâle, Phénomènes électrophysiologiques, Souris, Souris de lignée C57BL, Souris knockout, Transfection.
- MESH :
- analogues et dérivés : Acroléine.
- déficit : Canaux cationiques TRP.
- génétique : Canaux cationiques TRP.
- métabolisme : Calcium, Entérocytes.
- pharmacologie : Acroléine, Antagonistes des récepteurs 5-HT3 de la sérotonine, Composés phytochimiques, Isothiocyanates, Monoterpènes.
- physiologie : Côlon, Duodénum, Muqueuse intestinale.
- Aliments, Animaux, Canaux cationiques TRP, Cellules HEK293, Entérocytes, Expression des gènes, Humains, Muqueuse intestinale, Mâle, Phénomènes électrophysiologiques, Souris, Souris de lignée C57BL, Souris knockout, Transfection.
English descriptors
- KwdEn :
- Acrolein (analogs & derivatives), Acrolein (pharmacology), Animals, Calcium (metabolism), Colon (physiology), Duodenum (physiology), Electrophysiological Phenomena, Enterocytes (drug effects), Enterocytes (metabolism), Food, Gene Expression, HEK293 Cells, Humans, Intestinal Mucosa (chemistry), Intestinal Mucosa (physiology), Isothiocyanates (pharmacology), Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Monoterpenes (pharmacology), Phytochemicals (pharmacology), Serotonin 5-HT3 Receptor Antagonists (pharmacology), Transfection, Transient Receptor Potential Channels (deficiency), Transient Receptor Potential Channels (drug effects), Transient Receptor Potential Channels (genetics).
- MESH :
- chemical , analogs & derivatives : Acrolein.
- chemical , deficiency : Transient Receptor Potential Channels.
- chemical , drug effects : Transient Receptor Potential Channels.
- chemical , genetics : Transient Receptor Potential Channels.
- chemical , metabolism : Calcium.
- chemical , pharmacology : Acrolein, Isothiocyanates, Monoterpenes, Phytochemicals, Serotonin 5-HT3 Receptor Antagonists.
- chemistry : Intestinal Mucosa.
- drug effects : Enterocytes.
- metabolism : Enterocytes.
- physiology : Colon, Duodenum, Intestinal Mucosa.
- Animals, Electrophysiological Phenomena, Food, Gene Expression, HEK293 Cells, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Transfection.
Abstract
TRPA1 is a ligand-activated cation channel found in the intestine and other tissues. Components of food that stimulate TRPA1 receptors (phytonutrients) include allyl isothiocyanate, cinnamaldehyde and linalool, but these may also act at other receptors. Cells lining the intestinal mucosa are immunoreactive for TRPA1 and
Url:
DOI: 10.3390/nu8100623
PubMed: 27735854
PubMed Central: 5084011
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002819
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002669
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000986
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001722
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001699
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001699
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003D02
Links to Exploration step
PMC:5084011Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine</title>
<author><name sortKey="Fothergill, Linda J" sort="Fothergill, Linda J" uniqKey="Fothergill L" first="Linda J." last="Fothergill">Linda J. Fothergill</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Callaghan, Brid" sort="Callaghan, Brid" uniqKey="Callaghan B" first="Brid" last="Callaghan">Brid Callaghan</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rivera, Leni R" sort="Rivera, Leni R" uniqKey="Rivera L" first="Leni R." last="Rivera">Leni R. Rivera</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-nutrients-08-00623">Metabolic Research Unit, School of Medicine, Deakin University, Geelong VIC 3216, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Metabolic Research Unit, School of Medicine, Deakin University, Geelong VIC 3216</wicri:regionArea>
<wicri:noRegion>Geelong VIC 3216</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lieu, Tinamarie" sort="Lieu, Tinamarie" uniqKey="Lieu T" first="Tinamarie" last="Lieu">Tinamarie Lieu</name>
<affiliation><nlm:aff id="af3-nutrients-08-00623">Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia;<email>Tinamarie.lieu@monash.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Poole, Daniel P" sort="Poole, Daniel P" uniqKey="Poole D" first="Daniel P." last="Poole">Daniel P. Poole</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3-nutrients-08-00623">Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia;<email>Tinamarie.lieu@monash.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cho, Hyun Jung" sort="Cho, Hyun Jung" uniqKey="Cho H" first="Hyun-Jung" last="Cho">Hyun-Jung Cho</name>
<affiliation><nlm:aff id="af4-nutrients-08-00623">Biological Optical Microscopy Platform, University of Melbourne, Parkville VIC 3010, Australia;<email>hcho@unimelb.edu.au</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bravo, David M" sort="Bravo, David M" uniqKey="Bravo D" first="David M." last="Bravo">David M. Bravo</name>
<affiliation><nlm:aff id="af5-nutrients-08-00623">In Vivo Animal Nutrition & Health, Talhouët, Saint-Nolff 56250, France;<email>david.bravo@pancosma.ch</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Furness, John B" sort="Furness, John B" uniqKey="Furness J" first="John B." last="Furness">John B. Furness</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6-nutrients-08-00623">Florey Institute of Neuroscience and Mental Health, Parkville VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Florey Institute of Neuroscience and Mental Health, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27735854</idno>
<idno type="pmc">5084011</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084011</idno>
<idno type="RBID">PMC:5084011</idno>
<idno type="doi">10.3390/nu8100623</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">002819</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002819</idno>
<idno type="wicri:Area/Pmc/Curation">002669</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002669</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000986</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000986</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001722</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001722</idno>
<idno type="wicri:Area/PubMed/Curation">001699</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001699</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001699</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001699</idno>
<idno type="wicri:Area/Ncbi/Merge">003D02</idno>
<idno type="wicri:Area/Ncbi/Curation">003D02</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine</title>
<author><name sortKey="Fothergill, Linda J" sort="Fothergill, Linda J" uniqKey="Fothergill L" first="Linda J." last="Fothergill">Linda J. Fothergill</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Callaghan, Brid" sort="Callaghan, Brid" uniqKey="Callaghan B" first="Brid" last="Callaghan">Brid Callaghan</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rivera, Leni R" sort="Rivera, Leni R" uniqKey="Rivera L" first="Leni R." last="Rivera">Leni R. Rivera</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-nutrients-08-00623">Metabolic Research Unit, School of Medicine, Deakin University, Geelong VIC 3216, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Metabolic Research Unit, School of Medicine, Deakin University, Geelong VIC 3216</wicri:regionArea>
<wicri:noRegion>Geelong VIC 3216</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lieu, Tinamarie" sort="Lieu, Tinamarie" uniqKey="Lieu T" first="Tinamarie" last="Lieu">Tinamarie Lieu</name>
<affiliation><nlm:aff id="af3-nutrients-08-00623">Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia;<email>Tinamarie.lieu@monash.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Poole, Daniel P" sort="Poole, Daniel P" uniqKey="Poole D" first="Daniel P." last="Poole">Daniel P. Poole</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3-nutrients-08-00623">Monash Institute of Pharmaceutical Sciences, Monash University, Parkville VIC 3052, Australia;<email>Tinamarie.lieu@monash.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cho, Hyun Jung" sort="Cho, Hyun Jung" uniqKey="Cho H" first="Hyun-Jung" last="Cho">Hyun-Jung Cho</name>
<affiliation><nlm:aff id="af4-nutrients-08-00623">Biological Optical Microscopy Platform, University of Melbourne, Parkville VIC 3010, Australia;<email>hcho@unimelb.edu.au</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bravo, David M" sort="Bravo, David M" uniqKey="Bravo D" first="David M." last="Bravo">David M. Bravo</name>
<affiliation><nlm:aff id="af5-nutrients-08-00623">In Vivo Animal Nutrition & Health, Talhouët, Saint-Nolff 56250, France;<email>david.bravo@pancosma.ch</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Furness, John B" sort="Furness, John B" uniqKey="Furness J" first="John B." last="Furness">John B. Furness</name>
<affiliation><nlm:aff id="af1-nutrients-08-00623">Department of Anatomy & Neuroscience, University of Melbourne, Parkville VIC 3010, Australia;<email>b.callaghan@unimelb.edu.ac</email>
(B.C.);<email>leni.rivera@deakin.edu.au</email>
(L.R.R.);<email>Daniel.Poole@monash.edu</email>
(D.P.P.)</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6-nutrients-08-00623">Florey Institute of Neuroscience and Mental Health, Parkville VIC 3010, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Florey Institute of Neuroscience and Mental Health, Parkville VIC 3010</wicri:regionArea>
<wicri:noRegion>Parkville VIC 3010</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Nutrients</title>
<idno type="eISSN">2072-6643</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrolein (analogs & derivatives)</term>
<term>Acrolein (pharmacology)</term>
<term>Animals</term>
<term>Calcium (metabolism)</term>
<term>Colon (physiology)</term>
<term>Duodenum (physiology)</term>
<term>Electrophysiological Phenomena</term>
<term>Enterocytes (drug effects)</term>
<term>Enterocytes (metabolism)</term>
<term>Food</term>
<term>Gene Expression</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Intestinal Mucosa (chemistry)</term>
<term>Intestinal Mucosa (physiology)</term>
<term>Isothiocyanates (pharmacology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Monoterpenes (pharmacology)</term>
<term>Phytochemicals (pharmacology)</term>
<term>Serotonin 5-HT3 Receptor Antagonists (pharmacology)</term>
<term>Transfection</term>
<term>Transient Receptor Potential Channels (deficiency)</term>
<term>Transient Receptor Potential Channels (drug effects)</term>
<term>Transient Receptor Potential Channels (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acroléine (analogues et dérivés)</term>
<term>Acroléine (pharmacologie)</term>
<term>Aliments</term>
<term>Animaux</term>
<term>Antagonistes des récepteurs 5-HT3 de la sérotonine (pharmacologie)</term>
<term>Calcium (métabolisme)</term>
<term>Canaux cationiques TRP ()</term>
<term>Canaux cationiques TRP (déficit)</term>
<term>Canaux cationiques TRP (génétique)</term>
<term>Cellules HEK293</term>
<term>Composés phytochimiques (pharmacologie)</term>
<term>Côlon (physiologie)</term>
<term>Duodénum (physiologie)</term>
<term>Entérocytes ()</term>
<term>Entérocytes (métabolisme)</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Isothiocyanates (pharmacologie)</term>
<term>Monoterpènes (pharmacologie)</term>
<term>Muqueuse intestinale ()</term>
<term>Muqueuse intestinale (physiologie)</term>
<term>Mâle</term>
<term>Phénomènes électrophysiologiques</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Transfection</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Acrolein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Transient Receptor Potential Channels</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Transient Receptor Potential Channels</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Transient Receptor Potential Channels</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acrolein</term>
<term>Isothiocyanates</term>
<term>Monoterpenes</term>
<term>Phytochemicals</term>
<term>Serotonin 5-HT3 Receptor Antagonists</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acroléine</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Intestinal Mucosa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Enterocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Canaux cationiques TRP</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Canaux cationiques TRP</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Enterocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Calcium</term>
<term>Entérocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acroléine</term>
<term>Antagonistes des récepteurs 5-HT3 de la sérotonine</term>
<term>Composés phytochimiques</term>
<term>Isothiocyanates</term>
<term>Monoterpènes</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Côlon</term>
<term>Duodénum</term>
<term>Muqueuse intestinale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Colon</term>
<term>Duodenum</term>
<term>Intestinal Mucosa</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Electrophysiological Phenomena</term>
<term>Food</term>
<term>Gene Expression</term>
<term>HEK293 Cells</term>
<term>Humans</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Transfection</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Aliments</term>
<term>Animaux</term>
<term>Canaux cationiques TRP</term>
<term>Cellules HEK293</term>
<term>Entérocytes</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Muqueuse intestinale</term>
<term>Mâle</term>
<term>Phénomènes électrophysiologiques</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Transfection</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>TRPA1 is a ligand-activated cation channel found in the intestine and other tissues. Components of food that stimulate TRPA1 receptors (phytonutrients) include allyl isothiocyanate, cinnamaldehyde and linalool, but these may also act at other receptors. Cells lining the intestinal mucosa are immunoreactive for TRPA1 and <italic>Trpa1</italic>
mRNA occurs in mucosal extracts, suggesting that the TRPA1 receptor is the target for these agonists. However, in situ hybridisation reveals <italic>Trpa1</italic>
expression in 5-HT containing enteroendocrine cells, not enterocytes. TRPA1 agonists evoke mucosal secretion, which may be indirect (through release of 5-HT) or direct by activation of enterocytes. We investigated effects of the phytonutrients on transmucosal ion currents in mouse duodenum and colon, and the specificity of the phytonutrients in cells transfected with <italic>Trpa1</italic>
, and in <italic>Trpa1</italic>
-deficient mice. The phytonutrients increased currents in the duodenum with the relative potencies: allyl isothiocyanate (AITC) > cinnamaldehyde > linalool (0.1 to 300 μM). The rank order was similar in the colon, but linalool was ineffective. Responses to AITC were reduced by the TRPA1 antagonist HC-030031 (100 μM), and were greatly diminished in <italic>Trpa1</italic>
−/− duodenum and colon. Responses were not reduced by tetrodotoxin, 5-HT receptor antagonists, or atropine, but inhibition of prostaglandin synthesis reduced responses. Thus, functional TRPA1 channels are expressed by enterocytes of the duodenum and colon. Activation of enterocyte TRPA1 by food components has the potential to facilitate nutrient absorption.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rochfort, S" uniqKey="Rochfort S">S. Rochfort</name>
</author>
<author><name sortKey="Parker, A J" uniqKey="Parker A">A.J. Parker</name>
</author>
<author><name sortKey="Dunshea, F R" uniqKey="Dunshea F">F.R. Dunshea</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Windisch, W" uniqKey="Windisch W">W. Windisch</name>
</author>
<author><name sortKey="Schedle, K" uniqKey="Schedle K">K. Schedle</name>
</author>
<author><name sortKey="Plitzner, C" uniqKey="Plitzner C">C. Plitzner</name>
</author>
<author><name sortKey="Kroismayr, A" uniqKey="Kroismayr A">A. Kroismayr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Lange, C F M" uniqKey="De Lange C">C.F.M. De Lange</name>
</author>
<author><name sortKey="Pluske, J" uniqKey="Pluske J">J. Pluske</name>
</author>
<author><name sortKey="Gong, J" uniqKey="Gong J">J. Gong</name>
</author>
<author><name sortKey="Nyachoti, C M" uniqKey="Nyachoti C">C.M. Nyachoti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hashemi, S R" uniqKey="Hashemi S">S.R. Hashemi</name>
</author>
<author><name sortKey="Davoodi, H" uniqKey="Davoodi H">H. Davoodi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Michiels, J" uniqKey="Michiels J">J. Michiels</name>
</author>
<author><name sortKey="Missotten, J" uniqKey="Missotten J">J. Missotten</name>
</author>
<author><name sortKey="Van Hoorick, A" uniqKey="Van Hoorick A">A. Van Hoorick</name>
</author>
<author><name sortKey="Ovyn, A" uniqKey="Ovyn A">A. Ovyn</name>
</author>
<author><name sortKey="Fremaut, D" uniqKey="Fremaut D">D. Fremaut</name>
</author>
<author><name sortKey="De Smet, S" uniqKey="De Smet S">S. De Smet</name>
</author>
<author><name sortKey="Dierick, N" uniqKey="Dierick N">N. Dierick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bandell, M" uniqKey="Bandell M">M. Bandell</name>
</author>
<author><name sortKey="Story, G M" uniqKey="Story G">G.M. Story</name>
</author>
<author><name sortKey="Hwang, S W" uniqKey="Hwang S">S.W. Hwang</name>
</author>
<author><name sortKey="Viswanath, V" uniqKey="Viswanath V">V. Viswanath</name>
</author>
<author><name sortKey="Eid, S R" uniqKey="Eid S">S.R. Eid</name>
</author>
<author><name sortKey="Petrus, M J" uniqKey="Petrus M">M.J. Petrus</name>
</author>
<author><name sortKey="Earley, T J" uniqKey="Earley T">T.J. Earley</name>
</author>
<author><name sortKey="Patapoutian, A" uniqKey="Patapoutian A">A. Patapoutian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holzer, P" uniqKey="Holzer P">P. Holzer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riera, C E" uniqKey="Riera C">C.E. Riera</name>
</author>
<author><name sortKey="Menozzi Smarrito, C" uniqKey="Menozzi Smarrito C">C. Menozzi-Smarrito</name>
</author>
<author><name sortKey="Affolter, M" uniqKey="Affolter M">M. Affolter</name>
</author>
<author><name sortKey="Michlig, S" uniqKey="Michlig S">S. Michlig</name>
</author>
<author><name sortKey="Munari, C" uniqKey="Munari C">C. Munari</name>
</author>
<author><name sortKey="Robert, F" uniqKey="Robert F">F. Robert</name>
</author>
<author><name sortKey="Vogel, H" uniqKey="Vogel H">H. Vogel</name>
</author>
<author><name sortKey="Simon, S A" uniqKey="Simon S">S.A. Simon</name>
</author>
<author><name sortKey="Le Coutre, J" uniqKey="Le Coutre J">J. le Coutre</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Motter, A L" uniqKey="Motter A">A.L. Motter</name>
</author>
<author><name sortKey="Ahern, G P" uniqKey="Ahern G">G.P. Ahern</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandes, E S" uniqKey="Fernandes E">E.S. Fernandes</name>
</author>
<author><name sortKey="Fernandes, M A" uniqKey="Fernandes M">M.A. Fernandes</name>
</author>
<author><name sortKey="Keeble, J E" uniqKey="Keeble J">J.E. Keeble</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaji, I" uniqKey="Kaji I">I. Kaji</name>
</author>
<author><name sortKey="Yasuoka, Y" uniqKey="Yasuoka Y">Y. Yasuoka</name>
</author>
<author><name sortKey="Karaki, S I" uniqKey="Karaki S">S.I. Karaki</name>
</author>
<author><name sortKey="Kuwahara, A" uniqKey="Kuwahara A">A. Kuwahara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poole, D P" uniqKey="Poole D">D.P. Poole</name>
</author>
<author><name sortKey="Pelayo, J C" uniqKey="Pelayo J">J.C. Pelayo</name>
</author>
<author><name sortKey="Cattaruzza, F" uniqKey="Cattaruzza F">F. Cattaruzza</name>
</author>
<author><name sortKey="Kuo, Y M" uniqKey="Kuo Y">Y.M. Kuo</name>
</author>
<author><name sortKey="Gai, G" uniqKey="Gai G">G. Gai</name>
</author>
<author><name sortKey="Chiu, J V" uniqKey="Chiu J">J.V. Chiu</name>
</author>
<author><name sortKey="Bron, R" uniqKey="Bron R">R. Bron</name>
</author>
<author><name sortKey="Furness, J B" uniqKey="Furness J">J.B. Furness</name>
</author>
<author><name sortKey="Grady, E F" uniqKey="Grady E">E.F. Grady</name>
</author>
<author><name sortKey="Bunnett, N W" uniqKey="Bunnett N">N.W. Bunnett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cho, H J" uniqKey="Cho H">H.J. Cho</name>
</author>
<author><name sortKey="Callaghan, B" uniqKey="Callaghan B">B. Callaghan</name>
</author>
<author><name sortKey="Bron, R" uniqKey="Bron R">R. Bron</name>
</author>
<author><name sortKey="Bravo, D M" uniqKey="Bravo D">D.M. Bravo</name>
</author>
<author><name sortKey="Furness, J B" uniqKey="Furness J">J.B. Furness</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Purhonen, A K" uniqKey="Purhonen A">A.K. Purhonen</name>
</author>
<author><name sortKey="Louhivuori, L M" uniqKey="Louhivuori L">L.M. Louhivuori</name>
</author>
<author><name sortKey="Kiehne, K" uniqKey="Kiehne K">K. Kiehne</name>
</author>
<author><name sortKey="Akerman, K E O" uniqKey="Akerman K">K.E.O. Akerman</name>
</author>
<author><name sortKey="Herzig, K H" uniqKey="Herzig K">K.H. Herzig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nozawa, K" uniqKey="Nozawa K">K. Nozawa</name>
</author>
<author><name sortKey="Kawabata Shoda, E" uniqKey="Kawabata Shoda E">E. Kawabata-Shoda</name>
</author>
<author><name sortKey="Doihara, H" uniqKey="Doihara H">H. Doihara</name>
</author>
<author><name sortKey="Kojima, R" uniqKey="Kojima R">R. Kojima</name>
</author>
<author><name sortKey="Okada, H" uniqKey="Okada H">H. Okada</name>
</author>
<author><name sortKey="Mochizuki, S" uniqKey="Mochizuki S">S. Mochizuki</name>
</author>
<author><name sortKey="Sano, Y" uniqKey="Sano Y">Y. Sano</name>
</author>
<author><name sortKey="Inamura, K" uniqKey="Inamura K">K. Inamura</name>
</author>
<author><name sortKey="Matsushime, H" uniqKey="Matsushime H">H. Matsushime</name>
</author>
<author><name sortKey="Koizumi, T" uniqKey="Koizumi T">T. Koizumi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boudry, G" uniqKey="Boudry G">G. Boudry</name>
</author>
<author><name sortKey="Perrier, C" uniqKey="Perrier C">C. Perrier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Youn, H S" uniqKey="Youn H">H.S. Youn</name>
</author>
<author><name sortKey="Lee, J K" uniqKey="Lee J">J.K. Lee</name>
</author>
<author><name sortKey="Choi, Y J" uniqKey="Choi Y">Y.J. Choi</name>
</author>
<author><name sortKey="Saitoh, S I" uniqKey="Saitoh S">S.I. Saitoh</name>
</author>
<author><name sortKey="Miyake, K" uniqKey="Miyake K">K. Miyake</name>
</author>
<author><name sortKey="Hwang, D H" uniqKey="Hwang D">D.H. Hwang</name>
</author>
<author><name sortKey="Lee, J Y" uniqKey="Lee J">J.Y. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kwan, K Y" uniqKey="Kwan K">K.Y. Kwan</name>
</author>
<author><name sortKey="Allchorne, A J" uniqKey="Allchorne A">A.J. Allchorne</name>
</author>
<author><name sortKey="Vollrath, M A" uniqKey="Vollrath M">M.A. Vollrath</name>
</author>
<author><name sortKey="Christensen, A P" uniqKey="Christensen A">A.P. Christensen</name>
</author>
<author><name sortKey="Zhang, D S" uniqKey="Zhang D">D.S. Zhang</name>
</author>
<author><name sortKey="Woolf, C J" uniqKey="Woolf C">C.J. Woolf</name>
</author>
<author><name sortKey="Corey, D P" uniqKey="Corey D">D.P. Corey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poole, D P" uniqKey="Poole D">D.P. Poole</name>
</author>
<author><name sortKey="Amadesi, S" uniqKey="Amadesi S">S. Amadesi</name>
</author>
<author><name sortKey="Veldhuis, N A" uniqKey="Veldhuis N">N.A. Veldhuis</name>
</author>
<author><name sortKey="Abogadie, F C" uniqKey="Abogadie F">F.C. Abogadie</name>
</author>
<author><name sortKey="Lieu, T M" uniqKey="Lieu T">T.M. Lieu</name>
</author>
<author><name sortKey="Darby, W" uniqKey="Darby W">W. Darby</name>
</author>
<author><name sortKey="Liedtke, W" uniqKey="Liedtke W">W. Liedtke</name>
</author>
<author><name sortKey="Lew, M J" uniqKey="Lew M">M.J. Lew</name>
</author>
<author><name sortKey="Mcintyre, P" uniqKey="Mcintyre P">P. McIntyre</name>
</author>
<author><name sortKey="Bunnett, N W" uniqKey="Bunnett N">N.W. Bunnett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Callaghan, B" uniqKey="Callaghan B">B. Callaghan</name>
</author>
<author><name sortKey="Hunne, B" uniqKey="Hunne B">B. Hunne</name>
</author>
<author><name sortKey="Hirayama, H" uniqKey="Hirayama H">H. Hirayama</name>
</author>
<author><name sortKey="Sartor, D M" uniqKey="Sartor D">D.M. Sartor</name>
</author>
<author><name sortKey="Nguyen, T V" uniqKey="Nguyen T">T.V. Nguyen</name>
</author>
<author><name sortKey="Abogadie, F C" uniqKey="Abogadie F">F.C. Abogadie</name>
</author>
<author><name sortKey="Ferens, D" uniqKey="Ferens D">D. Ferens</name>
</author>
<author><name sortKey="Mcintyre, P" uniqKey="Mcintyre P">P. McIntyre</name>
</author>
<author><name sortKey="Ban, K" uniqKey="Ban K">K. Ban</name>
</author>
<author><name sortKey="Baell, J" uniqKey="Baell J">J. Baell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Field, M" uniqKey="Field M">M. Field</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clarke, L L" uniqKey="Clarke L">L.L. Clarke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cooke, H J" uniqKey="Cooke H">H.J. Cooke</name>
</author>
<author><name sortKey="Wang, Y Z" uniqKey="Wang Y">Y.Z. Wang</name>
</author>
<author><name sortKey="Frieling, T" uniqKey="Frieling T">T. Frieling</name>
</author>
<author><name sortKey="Wood, J D" uniqKey="Wood J">J.D. Wood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neal, K B" uniqKey="Neal K">K.B. Neal</name>
</author>
<author><name sortKey="Bornstein, J C" uniqKey="Bornstein J">J.C. Bornstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y Z" uniqKey="Wang Y">Y.Z. Wang</name>
</author>
<author><name sortKey="Cooke, H J" uniqKey="Cooke H">H.J. Cooke</name>
</author>
<author><name sortKey="Su, H C" uniqKey="Su H">H.C. Su</name>
</author>
<author><name sortKey="Fertel, R" uniqKey="Fertel R">R. Fertel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Christofi, F L" uniqKey="Christofi F">F.L. Christofi</name>
</author>
<author><name sortKey="Wunderlich, J" uniqKey="Wunderlich J">J. Wunderlich</name>
</author>
<author><name sortKey="Yu, J G" uniqKey="Yu J">J.G. Yu</name>
</author>
<author><name sortKey="Wang, Y Z" uniqKey="Wang Y">Y.Z. Wang</name>
</author>
<author><name sortKey="Xue, J" uniqKey="Xue J">J. Xue</name>
</author>
<author><name sortKey="Guzman, J" uniqKey="Guzman J">J. Guzman</name>
</author>
<author><name sortKey="Javed, N" uniqKey="Javed N">N. Javed</name>
</author>
<author><name sortKey="Cooke, H" uniqKey="Cooke H">H. Cooke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Staruschenko, A" uniqKey="Staruschenko A">A. Staruschenko</name>
</author>
<author><name sortKey="Jeske, N A" uniqKey="Jeske N">N.A. Jeske</name>
</author>
<author><name sortKey="Akopian, N C" uniqKey="Akopian N">N.C. Akopian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mace, O J" uniqKey="Mace O">O.J. Mace</name>
</author>
<author><name sortKey="Affleck, J" uniqKey="Affleck J">J. Affleck</name>
</author>
<author><name sortKey="Patel, N" uniqKey="Patel N">N. Patel</name>
</author>
<author><name sortKey="Kellett, G L" uniqKey="Kellett G">G.L. Kellett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mace, O J" uniqKey="Mace O">O.J. Mace</name>
</author>
<author><name sortKey="Morgan, E L" uniqKey="Morgan E">E.L. Morgan</name>
</author>
<author><name sortKey="Affleck, J A" uniqKey="Affleck J">J.A. Affleck</name>
</author>
<author><name sortKey="Lister, N" uniqKey="Lister N">N. Lister</name>
</author>
<author><name sortKey="Kellett, G L" uniqKey="Kellett G">G.L. Kellett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morgan, E L" uniqKey="Morgan E">E.L. Morgan</name>
</author>
<author><name sortKey="Mace, O J" uniqKey="Mace O">O.J. Mace</name>
</author>
<author><name sortKey="Affleck, J" uniqKey="Affleck J">J. Affleck</name>
</author>
<author><name sortKey="Kellett, G L" uniqKey="Kellett G">G.L. Kellett</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003D02 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 003D02 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:5084011 |texte= Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:27735854" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |