Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Identifieur interne : 003747 ( Ncbi/Curation ); précédent : 003746; suivant : 003748Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Auteurs : Liping Hou [États-Unis] ; Sarah E. Bergen [Suède] ; Nirmala Akula [États-Unis] ; Jie Song [Suède] ; Christina M. Hultman [Suède] ; Mikael Landén [Suède] ; Mazda Adli [Allemagne] ; Martin Alda [Canada] ; Raffaella Ardau [Italie] ; Bárbara Arias [Espagne] ; Jean-Michel Aubry [Suisse] ; Lena Backlund [Suède] ; Judith A. Badner [États-Unis] ; Thomas B. Barrett [États-Unis] ; Michael Bauer [Allemagne] ; Bernhard T. Baune [Australie] ; Frank Bellivier [France] ; Antonio Benabarre [Espagne] ; Susanne Bengesser [Autriche] ; Wade H. Berrettini [États-Unis] ; Abesh Kumar Bhattacharjee [États-Unis] ; Joanna M. Biernacka [États-Unis] ; Armin Birner [Autriche] ; Cinnamon S. Bloss [États-Unis] ; Clara Brichant-Petitjean [France] ; Elise T. Bui [États-Unis] ; William Byerley [États-Unis] ; Pablo Cervantes [Canada] ; Caterina Chillotti [Italie] ; Sven Cichon [Allemagne] ; Francesc Colom [Espagne] ; William Coryell [États-Unis] ; David W. Craig [États-Unis] ; Cristiana Cruceanu [Canada] ; Piotr M. Czerski [Pologne] ; Tony Davis [Australie] ; Alexandre Dayer [Suisse] ; Franziska Degenhardt [Allemagne] ; Maria Del Zompo [Italie] ; J Raymond Depaulo [États-Unis] ; Howard J. Edenberg [États-Unis] ; Bruno Étain [France] ; Peter Falkai [Allemagne] ; Tatiana Foroud [États-Unis] ; Andreas J. Forstner [Allemagne] ; Louise Frisén [Suède] ; Mark A. Frye [États-Unis] ; Janice M. Fullerton [Australie] ; Sébastien Gard [France] ; Julie S. Garnham [Canada] ; Elliot S. Gershon [États-Unis] ; Fernando S. Goes [États-Unis] ; Tiffany A. Greenwood [États-Unis] ; Maria Grigoroiu-Serbanescu [Roumanie] ; Joanna Hauser [Pologne] ; Urs Heilbronner [Allemagne] ; Stefanie Heilmann-Heimbach [Allemagne] ; Stefan Herms [Allemagne] ; Maria Hipolito [États-Unis] ; Shashi Hitturlingappa [Australie] ; Per Hoffmann [Allemagne] ; Andrea Hofmann [Allemagne] ; Stephane Jamain [France] ; Esther Jiménez [Espagne] ; Jean-Pierre Kahn [France] ; Layla Kassem [États-Unis] ; John R. Kelsoe [États-Unis] ; Sarah Kittel-Schneider [Allemagne] ; Sebastian Kliwicki [Pologne] ; Daniel L. Koller [États-Unis] ; Barbara König [Autriche] ; Nina Lackner [Autriche] ; Gonzalo Laje [États-Unis] ; Maren Lang [Allemagne] ; Catharina Lavebratt [Suède] ; William B. Lawson [États-Unis] ; Marion Leboyer [France] ; Susan G. Leckband [États-Unis] ; Chunyu Liu [États-Unis] ; Anna Maaser [Allemagne] ; Pamela B. Mahon [États-Unis] ; Wolfgang Maier [Allemagne] ; Mario Maj [Italie] ; Mirko Manchia [Italie] ; Lina Martinsson [Suède] ; Michael J. Mccarthy [États-Unis] ; Susan L. Mcelroy [États-Unis] ; Melvin G. Mcinnis [États-Unis] ; Rebecca Mckinney [États-Unis] ; Philip B. Mitchell [Australie] ; Marina Mitjans [Espagne] ; Francis M. Mondimore [États-Unis] ; Palmiero Monteleone [Italie] ; Thomas W. Mühleisen [Allemagne] ; Caroline M. Nievergelt [États-Unis] ; Markus M. Nöthen [Allemagne] ; Tomas Novák [République tchèque] ; John I. Nurnberger [États-Unis] ; Evaristus A. Nwulia [États-Unis] ; Urban Ösby [Suède] ; Andrea Pfennig [Allemagne] ; James B. Potash [États-Unis] ; Peter Propping [Allemagne] ; Andreas Reif [Allemagne] ; Eva Reininghaus [Autriche] ; John Rice ; Marcella Rietschel [Allemagne] ; Guy A. Rouleau [Canada] ; Janusz K. Rybakowski [Pologne] ; Martin Schalling [Suède] ; William A. Scheftner [États-Unis] ; Peter R. Schofield [Australie] ; Nicholas J. Schork [États-Unis] ; Thomas G. Schulze [États-Unis] ; Johannes Schumacher [Allemagne] ; Barbara W. Schweizer [États-Unis] ; Giovanni Severino [Italie] ; Tatyana Shekhtman [États-Unis] ; Paul D. Shilling [États-Unis] ; Christian Simhandl ; Claire M. Slaney [Canada] ; Erin N. Smith [États-Unis] ; Alessio Squassina [Italie] ; Thomas Stamm [Allemagne] ; Pavla Stopkova [République tchèque] ; Fabian Streit [Allemagne] ; Jana Strohmaier [Allemagne] ; Szabolcs Szelinger [États-Unis] ; Sarah K. Tighe [États-Unis] ; Alfonso Tortorella [Italie] ; Gustavo Turecki [Canada] ; Eduard Vieta [Espagne] ; Julia Volkert [Allemagne] ; Stephanie H. Witt [Allemagne] ; Adam Wright [Australie] ; Peter P. Zandi [États-Unis] ; Peng Zhang [États-Unis] ; Sebastian Zollner [États-Unis] ; Francis J. Mcmahon [Israël]Source :
- Human molecular genetics [ 1460-2083 ] ; 2016.
Abstract
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 × 10 (-) (9); odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P = 4.53 × 10 (-) (9); OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
DOI: 10.1093/hmg/ddw181
PubMed: 27329760
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John Rice<affiliation><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine in St. Louis.</nlm:affiliation>
<wicri:noCountry code="subField">Washington University School of Medicine in St</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria and.</nlm:affiliation>
<wicri:noCountry code="subField">Austria and</wicri:noCountry>
</affiliation>
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<author><name sortKey="Benabarre, Antonio" sort="Benabarre, Antonio" uniqKey="Benabarre A" first="Antonio" last="Benabarre">Antonio Benabarre</name>
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<author><name sortKey="Bengesser, Susanne" sort="Bengesser, Susanne" uniqKey="Bengesser S" first="Susanne" last="Bengesser">Susanne Bengesser</name>
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<author><name sortKey="Berrettini, Wade H" sort="Berrettini, Wade H" uniqKey="Berrettini W" first="Wade H" last="Berrettini">Wade H. Berrettini</name>
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<author><name sortKey="Bhattacharjee, Abesh Kumar" sort="Bhattacharjee, Abesh Kumar" uniqKey="Bhattacharjee A" first="Abesh Kumar" last="Bhattacharjee">Abesh Kumar Bhattacharjee</name>
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<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
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<author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M" last="Biernacka">Joanna M. Biernacka</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
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<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN</wicri:regionArea>
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<author><name sortKey="Birner, Armin" sort="Birner, Armin" uniqKey="Birner A" first="Armin" last="Birner">Armin Birner</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
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<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
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<author><name sortKey="Bloss, Cinnamon S" sort="Bloss, Cinnamon S" uniqKey="Bloss C" first="Cinnamon S" last="Bloss">Cinnamon S. Bloss</name>
<affiliation wicri:level="2"><nlm:affiliation>Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
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<wicri:regionArea>Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Brichant Petitjean, Clara" sort="Brichant Petitjean, Clara" uniqKey="Brichant Petitjean C" first="Clara" last="Brichant-Petitjean">Clara Brichant-Petitjean</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Bui, Elise T" sort="Bui, Elise T" uniqKey="Bui E" first="Elise T" last="Bui">Elise T. Bui</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
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<author><name sortKey="Byerley, William" sort="Byerley, William" uniqKey="Byerley W" first="William" last="Byerley">William Byerley</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California at San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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<author><name sortKey="Cervantes, Pablo" sort="Cervantes, Pablo" uniqKey="Cervantes P" first="Pablo" last="Cervantes">Pablo Cervantes</name>
<affiliation wicri:level="1"><nlm:affiliation>McGill University Health Centre, Mood Disorders Program, Montreal, QC, Canada.</nlm:affiliation>
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<wicri:regionArea>McGill University Health Centre, Mood Disorders Program, Montreal, QC</wicri:regionArea>
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<author><name sortKey="Chillotti, Caterina" sort="Chillotti, Caterina" uniqKey="Chillotti C" first="Caterina" last="Chillotti">Caterina Chillotti</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari</wicri:regionArea>
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</author>
<author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coryell, William" sort="Coryell, William" uniqKey="Coryell W" first="William" last="Coryell">William Coryell</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Iowa Hospitals and Clinics, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Hospitals and Clinics, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Craig, David W" sort="Craig, David W" uniqKey="Craig D" first="David W" last="Craig">David W. Craig</name>
<affiliation wicri:level="2"><nlm:affiliation>The Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name>
<affiliation wicri:level="3"><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name>
<affiliation wicri:level="1"><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davis, Tony" sort="Davis, Tony" uniqKey="Davis T" first="Tony" last="Davis">Tony Davis</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Psychiatry, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dayer, Alexandre" sort="Dayer, Alexandre" uniqKey="Dayer A" first="Alexandre" last="Dayer">Alexandre Dayer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Depaulo, J Raymond" sort="Depaulo, J Raymond" uniqKey="Depaulo J" first="J Raymond" last="Depaulo">J Raymond Depaulo</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edenberg, Howard J" sort="Edenberg, Howard J" uniqKey="Edenberg H" first="Howard J" last="Edenberg">Howard J. Edenberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Étain">Bruno Étain</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frisen, Louise" sort="Frisen, Louise" uniqKey="Frisen L" first="Louise" last="Frisén">Louise Frisén</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name>
<affiliation wicri:level="3"><nlm:affiliation>Psychiatric Genetics, Neuroscience Research Australia, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Psychiatric Genetics, Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gard, Sebastien" sort="Gard, Sebastien" uniqKey="Gard S" first="Sébastien" last="Gard">Sébastien Gard</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garnham, Julie S" sort="Garnham, Julie S" uniqKey="Garnham J" first="Julie S" last="Garnham">Julie S. Garnham</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gershon, Elliot S" sort="Gershon, Elliot S" uniqKey="Gershon E" first="Elliot S" last="Gershon">Elliot S. Gershon</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goes, Fernando S" sort="Goes, Fernando S" uniqKey="Goes F" first="Fernando S" last="Goes">Fernando S. Goes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Greenwood, Tiffany A" sort="Greenwood, Tiffany A" uniqKey="Greenwood T" first="Tiffany A" last="Greenwood">Tiffany A. Greenwood</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name>
<affiliation wicri:level="1"><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name>
<affiliation wicri:level="1"><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heilbronner, Urs" sort="Heilbronner, Urs" uniqKey="Heilbronner U" first="Urs" last="Heilbronner">Urs Heilbronner</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heilmann Heimbach, Stefanie" sort="Heilmann Heimbach, Stefanie" uniqKey="Heilmann Heimbach S" first="Stefanie" last="Heilmann-Heimbach">Stefanie Heilmann-Heimbach</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hipolito, Maria" sort="Hipolito, Maria" uniqKey="Hipolito M" first="Maria" last="Hipolito">Maria Hipolito</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hitturlingappa, Shashi" sort="Hitturlingappa, Shashi" uniqKey="Hitturlingappa S" first="Shashi" last="Hitturlingappa">Shashi Hitturlingappa</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Psychiatry, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stephane" last="Jamain">Stephane Jamain</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jimenez, Esther" sort="Jimenez, Esther" uniqKey="Jimenez E" first="Esther" last="Jiménez">Esther Jiménez</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name>
<affiliation wicri:level="4"><nlm:affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Kassem, Layla" sort="Kassem, Layla" uniqKey="Kassem L" first="Layla" last="Kassem">Layla Kassem</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kelsoe, John R" sort="Kelsoe, John R" uniqKey="Kelsoe J" first="John R" last="Kelsoe">John R. Kelsoe</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kliwicki, Sebastian" sort="Kliwicki, Sebastian" uniqKey="Kliwicki S" first="Sebastian" last="Kliwicki">Sebastian Kliwicki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koller, Daniel L" sort="Koller, Daniel L" uniqKey="Koller D" first="Daniel L" last="Koller">Daniel L. Koller</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Konig, Barbara" sort="Konig, Barbara" uniqKey="Konig B" first="Barbara" last="König">Barbara König</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen</wicri:regionArea>
<wicri:noRegion>Neunkirchen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lackner, Nina" sort="Lackner, Nina" uniqKey="Lackner N" first="Nina" last="Lackner">Nina Lackner</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laje, Gonzalo" sort="Laje, Gonzalo" uniqKey="Laje G" first="Gonzalo" last="Laje">Gonzalo Laje</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lang, Maren" sort="Lang, Maren" uniqKey="Lang M" first="Maren" last="Lang">Maren Lang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lavebratt, Catharina" sort="Lavebratt, Catharina" uniqKey="Lavebratt C" first="Catharina" last="Lavebratt">Catharina Lavebratt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lawson, William B" sort="Lawson, William B" uniqKey="Lawson W" first="William B" last="Lawson">William B. Lawson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leckband, Susan G" sort="Leckband, Susan G" uniqKey="Leckband S" first="Susan G" last="Leckband">Susan G. Leckband</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Illinois at Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
<settlement type="city">Chicago</settlement>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Maaser, Anna" sort="Maaser, Anna" uniqKey="Maaser A" first="Anna" last="Maaser">Anna Maaser</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mahon, Pamela B" sort="Mahon, Pamela B" uniqKey="Mahon P" first="Pamela B" last="Mahon">Pamela B. Mahon</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maj, Mario" sort="Maj, Mario" uniqKey="Maj M" first="Mario" last="Maj">Mario Maj</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, University of Naples SUN, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manchia, Mirko" sort="Manchia, Mirko" uniqKey="Manchia M" first="Mirko" last="Manchia">Mirko Manchia</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinsson, Lina" sort="Martinsson, Lina" uniqKey="Martinsson L" first="Lina" last="Martinsson">Lina Martinsson</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Michael J" sort="Mccarthy, Michael J" uniqKey="Mccarthy M" first="Michael J" last="Mccarthy">Michael J. Mccarthy</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcelroy, Susan L" sort="Mcelroy, Susan L" uniqKey="Mcelroy S" first="Susan L" last="Mcelroy">Susan L. Mcelroy</name>
<affiliation wicri:level="2"><nlm:affiliation>Lindner Center of HOPE, University of Cincinnati College of Medicine, Mason, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lindner Center of HOPE, University of Cincinnati College of Medicine, Mason, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcinnis, Melvin G" sort="Mcinnis, Melvin G" uniqKey="Mcinnis M" first="Melvin G" last="Mcinnis">Melvin G. Mcinnis</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mckinney, Rebecca" sort="Mckinney, Rebecca" uniqKey="Mckinney R" first="Rebecca" last="Mckinney">Rebecca Mckinney</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitjans, Marina" sort="Mitjans, Marina" uniqKey="Mitjans M" first="Marina" last="Mitjans">Marina Mitjans</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Mondimore, Francis M" sort="Mondimore, Francis M" uniqKey="Mondimore F" first="Francis M" last="Mondimore">Francis M. Mondimore</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monteleone, Palmiero" sort="Monteleone, Palmiero" uniqKey="Monteleone P" first="Palmiero" last="Monteleone">Palmiero Monteleone</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, University of Naples SUN, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W" last="Mühleisen">Thomas W. Mühleisen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nievergelt, Caroline M" sort="Nievergelt, Caroline M" uniqKey="Nievergelt C" first="Caroline M" last="Nievergelt">Caroline M. Nievergelt</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novak, Tomas" sort="Novak, Tomas" uniqKey="Novak T" first="Tomas" last="Novák">Tomas Novák</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Mental Health, Klecany</wicri:regionArea>
<wicri:noRegion>Klecany</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nurnberger, John I" sort="Nurnberger, John I" uniqKey="Nurnberger J" first="John I" last="Nurnberger">John I. Nurnberger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nwulia, Evaristus A" sort="Nwulia, Evaristus A" uniqKey="Nwulia E" first="Evaristus A" last="Nwulia">Evaristus A. Nwulia</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Ösby">Urban Ösby</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Potash, James B" sort="Potash, James B" uniqKey="Potash J" first="James B" last="Potash">James B. Potash</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reininghaus, Eva" sort="Reininghaus, Eva" uniqKey="Reininghaus E" first="Eva" last="Reininghaus">Eva Reininghaus</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rice, John" sort="Rice, John" uniqKey="Rice J" first="John" last="Rice">John Rice</name>
<affiliation><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine in St. Louis.</nlm:affiliation>
<wicri:noCountry code="subField">Washington University School of Medicine in St</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name>
<affiliation wicri:level="4"><nlm:affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Neurological Institute and Hospital, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Rybakowski, Janusz K" sort="Rybakowski, Janusz K" uniqKey="Rybakowski J" first="Janusz K" last="Rybakowski">Janusz K. Rybakowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheftner, William A" sort="Scheftner, William A" uniqKey="Scheftner W" first="William A" last="Scheftner">William A. Scheftner</name>
<affiliation wicri:level="2"><nlm:affiliation>Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<author><name sortKey="Schork, Nicholas J" sort="Schork, Nicholas J" uniqKey="Schork N" first="Nicholas J" last="Schork">Nicholas J. Schork</name>
<affiliation wicri:level="2"><nlm:affiliation>Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
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</author>
<author><name sortKey="Schweizer, Barbara W" sort="Schweizer, Barbara W" uniqKey="Schweizer B" first="Barbara W" last="Schweizer">Barbara W. Schweizer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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</affiliation>
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<author><name sortKey="Severino, Giovanni" sort="Severino, Giovanni" uniqKey="Severino G" first="Giovanni" last="Severino">Giovanni Severino</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
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</author>
<author><name sortKey="Shekhtman, Tatyana" sort="Shekhtman, Tatyana" uniqKey="Shekhtman T" first="Tatyana" last="Shekhtman">Tatyana Shekhtman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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</affiliation>
</author>
<author><name sortKey="Shilling, Paul D" sort="Shilling, Paul D" uniqKey="Shilling P" first="Paul D" last="Shilling">Paul D. Shilling</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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</affiliation>
</author>
<author><name sortKey="Simhandl, Christian" sort="Simhandl, Christian" uniqKey="Simhandl C" first="Christian" last="Simhandl">Christian Simhandl</name>
<affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria and.</nlm:affiliation>
<wicri:noCountry code="subField">Austria and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Slaney, Claire M" sort="Slaney, Claire M" uniqKey="Slaney C" first="Claire M" last="Slaney">Claire M. Slaney</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
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</author>
<author><name sortKey="Smith, Erin N" sort="Smith, Erin N" uniqKey="Smith E" first="Erin N" last="Smith">Erin N. Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Squassina, Alessio" sort="Squassina, Alessio" uniqKey="Squassina A" first="Alessio" last="Squassina">Alessio Squassina</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
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</author>
<author><name sortKey="Stamm, Thomas" sort="Stamm, Thomas" uniqKey="Stamm T" first="Thomas" last="Stamm">Thomas Stamm</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
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<author><name sortKey="Stopkova, Pavla" sort="Stopkova, Pavla" uniqKey="Stopkova P" first="Pavla" last="Stopkova">Pavla Stopkova</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Mental Health, Klecany</wicri:regionArea>
<wicri:noRegion>Klecany</wicri:noRegion>
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<author><name sortKey="Streit, Fabian" sort="Streit, Fabian" uniqKey="Streit F" first="Fabian" last="Streit">Fabian Streit</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
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</author>
<author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
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<author><name sortKey="Szelinger, Szabolcs" sort="Szelinger, Szabolcs" uniqKey="Szelinger S" first="Szabolcs" last="Szelinger">Szabolcs Szelinger</name>
<affiliation wicri:level="2"><nlm:affiliation>The Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
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</author>
<author><name sortKey="Tighe, Sarah K" sort="Tighe, Sarah K" uniqKey="Tighe S" first="Sarah K" last="Tighe">Sarah K. Tighe</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tortorella, Alfonso" sort="Tortorella, Alfonso" uniqKey="Tortorella A" first="Alfonso" last="Tortorella">Alfonso Tortorella</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, University of Naples SUN, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
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</author>
<author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
<affiliation wicri:level="3"><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Volkert, Julia" sort="Volkert, Julia" uniqKey="Volkert J" first="Julia" last="Volkert">Julia Volkert</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H" last="Witt">Stephanie H. Witt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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</affiliation>
</author>
<author><name sortKey="Zandi, Peter P" sort="Zandi, Peter P" uniqKey="Zandi P" first="Peter P" last="Zandi">Peter P. Zandi</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
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<author><name sortKey="Zollner, Sebastian" sort="Zollner, Sebastian" uniqKey="Zollner S" first="Sebastian" last="Zollner">Sebastian Zollner</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J" last="Mcmahon">Francis J. Mcmahon</name>
<affiliation wicri:level="1"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA, mcmahonf@mail.nih.gov.</nlm:affiliation>
<country wicri:rule="url">Israël</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.</title>
<author><name sortKey="Hou, Liping" sort="Hou, Liping" uniqKey="Hou L" first="Liping" last="Hou">Liping Hou</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bergen, Sarah E" sort="Bergen, Sarah E" uniqKey="Bergen S" first="Sarah E" last="Bergen">Sarah E. Bergen</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Akula, Nirmala" sort="Akula, Nirmala" uniqKey="Akula N" first="Nirmala" last="Akula">Nirmala Akula</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Song, Jie" sort="Song, Jie" uniqKey="Song J" first="Jie" last="Song">Jie Song</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hultman, Christina M" sort="Hultman, Christina M" uniqKey="Hultman C" first="Christina M" last="Hultman">Christina M. Hultman</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Gothenburg</wicri:regionArea>
<wicri:noRegion>Gothenburg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adli, Mazda" sort="Adli, Mazda" uniqKey="Adli M" first="Mazda" last="Adli">Mazda Adli</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ardau, Raffaella" sort="Ardau, Raffaella" uniqKey="Ardau R" first="Raffaella" last="Ardau">Raffaella Ardau</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arias, Barbara" sort="Arias, Barbara" uniqKey="Arias B" first="Bárbara" last="Arias">Bárbara Arias</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Aubry, Jean Michel" sort="Aubry, Jean Michel" uniqKey="Aubry J" first="Jean-Michel" last="Aubry">Jean-Michel Aubry</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Backlund, Lena" sort="Backlund, Lena" uniqKey="Backlund L" first="Lena" last="Backlund">Lena Backlund</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
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</affiliation>
</author>
<author><name sortKey="Badner, Judith A" sort="Badner, Judith A" uniqKey="Badner J" first="Judith A" last="Badner">Judith A. Badner</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barrett, Thomas B" sort="Barrett, Thomas B" uniqKey="Barrett T" first="Thomas B" last="Barrett">Thomas B. Barrett</name>
<affiliation wicri:level="2"><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, OR, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, OR</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baune, Bernhard T" sort="Baune, Bernhard T" uniqKey="Baune B" first="Bernhard T" last="Baune">Bernhard T. Baune</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Psychiatry, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM UMR-S 1144 - Université Paris Diderot. Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR-S 1144 - Université Paris Diderot. Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benabarre, Antonio" sort="Benabarre, Antonio" uniqKey="Benabarre A" first="Antonio" last="Benabarre">Antonio Benabarre</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bengesser, Susanne" sort="Bengesser, Susanne" uniqKey="Bengesser S" first="Susanne" last="Bengesser">Susanne Bengesser</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Berrettini, Wade H" sort="Berrettini, Wade H" uniqKey="Berrettini W" first="Wade H" last="Berrettini">Wade H. Berrettini</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhattacharjee, Abesh Kumar" sort="Bhattacharjee, Abesh Kumar" uniqKey="Bhattacharjee A" first="Abesh Kumar" last="Bhattacharjee">Abesh Kumar Bhattacharjee</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M" last="Biernacka">Joanna M. Biernacka</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Birner, Armin" sort="Birner, Armin" uniqKey="Birner A" first="Armin" last="Birner">Armin Birner</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bloss, Cinnamon S" sort="Bloss, Cinnamon S" uniqKey="Bloss C" first="Cinnamon S" last="Bloss">Cinnamon S. Bloss</name>
<affiliation wicri:level="2"><nlm:affiliation>Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brichant Petitjean, Clara" sort="Brichant Petitjean, Clara" uniqKey="Brichant Petitjean C" first="Clara" last="Brichant-Petitjean">Clara Brichant-Petitjean</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM UMR-S 1144 - Université Paris Diderot. Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR-S 1144 - Université Paris Diderot. Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bui, Elise T" sort="Bui, Elise T" uniqKey="Bui E" first="Elise T" last="Bui">Elise T. Bui</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Byerley, William" sort="Byerley, William" uniqKey="Byerley W" first="William" last="Byerley">William Byerley</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California at San Francisco, San Francisco, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cervantes, Pablo" sort="Cervantes, Pablo" uniqKey="Cervantes P" first="Pablo" last="Cervantes">Pablo Cervantes</name>
<affiliation wicri:level="1"><nlm:affiliation>McGill University Health Centre, Mood Disorders Program, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>McGill University Health Centre, Mood Disorders Program, Montreal, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chillotti, Caterina" sort="Chillotti, Caterina" uniqKey="Chillotti C" first="Caterina" last="Chillotti">Caterina Chillotti</name>
<affiliation wicri:level="1"><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coryell, William" sort="Coryell, William" uniqKey="Coryell W" first="William" last="Coryell">William Coryell</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Iowa Hospitals and Clinics, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa Hospitals and Clinics, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Craig, David W" sort="Craig, David W" uniqKey="Craig D" first="David W" last="Craig">David W. Craig</name>
<affiliation wicri:level="2"><nlm:affiliation>The Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name>
<affiliation wicri:level="3"><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name>
<affiliation wicri:level="1"><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davis, Tony" sort="Davis, Tony" uniqKey="Davis T" first="Tony" last="Davis">Tony Davis</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Psychiatry, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dayer, Alexandre" sort="Dayer, Alexandre" uniqKey="Dayer A" first="Alexandre" last="Dayer">Alexandre Dayer</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Mental Health and Psychiatry, Mood Disorders Unit, Geneva University Hospitals, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Depaulo, J Raymond" sort="Depaulo, J Raymond" uniqKey="Depaulo J" first="J Raymond" last="Depaulo">J Raymond Depaulo</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edenberg, Howard J" sort="Edenberg, Howard J" uniqKey="Edenberg H" first="Howard J" last="Edenberg">Howard J. Edenberg</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Étain">Bruno Étain</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Frisen, Louise" sort="Frisen, Louise" uniqKey="Frisen L" first="Louise" last="Frisén">Louise Frisén</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name>
<affiliation wicri:level="3"><nlm:affiliation>Psychiatric Genetics, Neuroscience Research Australia, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Psychiatric Genetics, Neuroscience Research Australia, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gard, Sebastien" sort="Gard, Sebastien" uniqKey="Gard S" first="Sébastien" last="Gard">Sébastien Gard</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Psychiatrie, Hôpital Charles Perrens, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garnham, Julie S" sort="Garnham, Julie S" uniqKey="Garnham J" first="Julie S" last="Garnham">Julie S. Garnham</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gershon, Elliot S" sort="Gershon, Elliot S" uniqKey="Gershon E" first="Elliot S" last="Gershon">Elliot S. Gershon</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goes, Fernando S" sort="Goes, Fernando S" uniqKey="Goes F" first="Fernando S" last="Goes">Fernando S. Goes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Greenwood, Tiffany A" sort="Greenwood, Tiffany A" uniqKey="Greenwood T" first="Tiffany A" last="Greenwood">Tiffany A. Greenwood</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name>
<affiliation wicri:level="1"><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name>
<affiliation wicri:level="1"><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Heilbronner, Urs" sort="Heilbronner, Urs" uniqKey="Heilbronner U" first="Urs" last="Heilbronner">Urs Heilbronner</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heilmann Heimbach, Stefanie" sort="Heilmann Heimbach, Stefanie" uniqKey="Heilmann Heimbach S" first="Stefanie" last="Heilmann-Heimbach">Stefanie Heilmann-Heimbach</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hipolito, Maria" sort="Hipolito, Maria" uniqKey="Hipolito M" first="Maria" last="Hipolito">Maria Hipolito</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hitturlingappa, Shashi" sort="Hitturlingappa, Shashi" uniqKey="Hitturlingappa S" first="Shashi" last="Hitturlingappa">Shashi Hitturlingappa</name>
<affiliation wicri:level="1"><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Discipline of Psychiatry, University of Adelaide, Adelaide</wicri:regionArea>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stephane" last="Jamain">Stephane Jamain</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jimenez, Esther" sort="Jimenez, Esther" uniqKey="Jimenez E" first="Esther" last="Jiménez">Esther Jiménez</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name>
<affiliation wicri:level="4"><nlm:affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy</wicri:regionArea>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Kassem, Layla" sort="Kassem, Layla" uniqKey="Kassem L" first="Layla" last="Kassem">Layla Kassem</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kelsoe, John R" sort="Kelsoe, John R" uniqKey="Kelsoe J" first="John R" last="Kelsoe">John R. Kelsoe</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kliwicki, Sebastian" sort="Kliwicki, Sebastian" uniqKey="Kliwicki S" first="Sebastian" last="Kliwicki">Sebastian Kliwicki</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koller, Daniel L" sort="Koller, Daniel L" uniqKey="Koller D" first="Daniel L" last="Koller">Daniel L. Koller</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Konig, Barbara" sort="Konig, Barbara" uniqKey="Konig B" first="Barbara" last="König">Barbara König</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapeuthic Medicine, Landesklinikum Neunkirchen, Neunkirchen</wicri:regionArea>
<wicri:noRegion>Neunkirchen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lackner, Nina" sort="Lackner, Nina" uniqKey="Lackner N" first="Nina" last="Lackner">Nina Lackner</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laje, Gonzalo" sort="Laje, Gonzalo" uniqKey="Laje G" first="Gonzalo" last="Laje">Gonzalo Laje</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lang, Maren" sort="Lang, Maren" uniqKey="Lang M" first="Maren" last="Lang">Maren Lang</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lavebratt, Catharina" sort="Lavebratt, Catharina" uniqKey="Lavebratt C" first="Catharina" last="Lavebratt">Catharina Lavebratt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lawson, William B" sort="Lawson, William B" uniqKey="Lawson W" first="William B" last="Lawson">William B. Lawson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U955, Psychiatrie translationnelle, Université Paris Est Créteil, Pôle de Psychiatrie et d'Addictologie, Hôpitaux Universitaires Henri Mondor, Créteil</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Créteil</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leckband, Susan G" sort="Leckband, Susan G" uniqKey="Leckband S" first="Susan G" last="Leckband">Susan G. Leckband</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Chunyu" sort="Liu, Chunyu" uniqKey="Liu C" first="Chunyu" last="Liu">Chunyu Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Illinois at Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
<settlement type="city">Chicago</settlement>
</placeName>
<orgName type="university">Université de l'Illinois à Chicago</orgName>
</affiliation>
</author>
<author><name sortKey="Maaser, Anna" sort="Maaser, Anna" uniqKey="Maaser A" first="Anna" last="Maaser">Anna Maaser</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mahon, Pamela B" sort="Mahon, Pamela B" uniqKey="Mahon P" first="Pamela B" last="Mahon">Pamela B. Mahon</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maj, Mario" sort="Maj, Mario" uniqKey="Maj M" first="Mario" last="Maj">Mario Maj</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, University of Naples SUN, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Manchia, Mirko" sort="Manchia, Mirko" uniqKey="Manchia M" first="Mirko" last="Manchia">Mirko Manchia</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinsson, Lina" sort="Martinsson, Lina" uniqKey="Martinsson L" first="Lina" last="Martinsson">Lina Martinsson</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Clinical Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Michael J" sort="Mccarthy, Michael J" uniqKey="Mccarthy M" first="Michael J" last="Mccarthy">Michael J. Mccarthy</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcelroy, Susan L" sort="Mcelroy, Susan L" uniqKey="Mcelroy S" first="Susan L" last="Mcelroy">Susan L. Mcelroy</name>
<affiliation wicri:level="2"><nlm:affiliation>Lindner Center of HOPE, University of Cincinnati College of Medicine, Mason, OH, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Lindner Center of HOPE, University of Cincinnati College of Medicine, Mason, OH</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcinnis, Melvin G" sort="Mcinnis, Melvin G" uniqKey="Mcinnis M" first="Melvin G" last="Mcinnis">Melvin G. Mcinnis</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mckinney, Rebecca" sort="Mckinney, Rebecca" uniqKey="Mckinney R" first="Rebecca" last="Mckinney">Rebecca Mckinney</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mitjans, Marina" sort="Mitjans, Marina" uniqKey="Mitjans M" first="Marina" last="Mitjans">Marina Mitjans</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Biologia Animal, Unitat d'Antropologia (Dp. Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
<settlement type="city">Barcelone</settlement>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Mondimore, Francis M" sort="Mondimore, Francis M" uniqKey="Mondimore F" first="Francis M" last="Mondimore">Francis M. Mondimore</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monteleone, Palmiero" sort="Monteleone, Palmiero" uniqKey="Monteleone P" first="Palmiero" last="Monteleone">Palmiero Monteleone</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, University of Naples SUN, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W" last="Mühleisen">Thomas W. Mühleisen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nievergelt, Caroline M" sort="Nievergelt, Caroline M" uniqKey="Nievergelt C" first="Caroline M" last="Nievergelt">Caroline M. Nievergelt</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Novak, Tomas" sort="Novak, Tomas" uniqKey="Novak T" first="Tomas" last="Novák">Tomas Novák</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Mental Health, Klecany</wicri:regionArea>
<wicri:noRegion>Klecany</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nurnberger, John I" sort="Nurnberger, John I" uniqKey="Nurnberger J" first="John I" last="Nurnberger">John I. Nurnberger</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nwulia, Evaristus A" sort="Nwulia, Evaristus A" uniqKey="Nwulia E" first="Evaristus A" last="Nwulia">Evaristus A. Nwulia</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Ösby">Urban Ösby</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden</wicri:regionArea>
<placeName><region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Dresde</region>
<settlement type="city">Dresde</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Potash, James B" sort="Potash, James B" uniqKey="Potash J" first="James B" last="Potash">James B. Potash</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reininghaus, Eva" sort="Reininghaus, Eva" uniqKey="Reininghaus E" first="Eva" last="Reininghaus">Eva Reininghaus</name>
<affiliation wicri:level="1"><nlm:affiliation>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Special Outpatient Center for Bipolar Affective Disorder, Medical University of Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rice, John" sort="Rice, John" uniqKey="Rice J" first="John" last="Rice">John Rice</name>
<affiliation><nlm:affiliation>Department of Psychiatry, Washington University School of Medicine in St. Louis.</nlm:affiliation>
<wicri:noCountry code="subField">Washington University School of Medicine in St</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name>
<affiliation wicri:level="4"><nlm:affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Montreal Neurological Institute and Hospital, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Rybakowski, Janusz K" sort="Rybakowski, Janusz K" uniqKey="Rybakowski J" first="Janusz K" last="Rybakowski">Janusz K. Rybakowski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan</wicri:regionArea>
<wicri:noRegion>Poznan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheftner, William A" sort="Scheftner, William A" uniqKey="Scheftner W" first="William A" last="Scheftner">William A. Scheftner</name>
<affiliation wicri:level="2"><nlm:affiliation>Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Medical Sciences, University of New South Wales, Sydney, NSW, 2052</wicri:regionArea>
<wicri:noRegion>2052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schork, Nicholas J" sort="Schork, Nicholas J" uniqKey="Schork N" first="Nicholas J" last="Schork">Nicholas J. Schork</name>
<affiliation wicri:level="2"><nlm:affiliation>Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name>
<affiliation wicri:level="2"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Human Genetics, University of Bonn, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Bonn</wicri:regionArea>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
<wicri:noRegion>University of Bonn</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schweizer, Barbara W" sort="Schweizer, Barbara W" uniqKey="Schweizer B" first="Barbara W" last="Schweizer">Barbara W. Schweizer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Severino, Giovanni" sort="Severino, Giovanni" uniqKey="Severino G" first="Giovanni" last="Severino">Giovanni Severino</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shekhtman, Tatyana" sort="Shekhtman, Tatyana" uniqKey="Shekhtman T" first="Tatyana" last="Shekhtman">Tatyana Shekhtman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shilling, Paul D" sort="Shilling, Paul D" uniqKey="Shilling P" first="Paul D" last="Shilling">Paul D. Shilling</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of California San Diego, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simhandl, Christian" sort="Simhandl, Christian" uniqKey="Simhandl C" first="Christian" last="Simhandl">Christian Simhandl</name>
<affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria and.</nlm:affiliation>
<wicri:noCountry code="subField">Austria and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Slaney, Claire M" sort="Slaney, Claire M" uniqKey="Slaney C" first="Claire M" last="Slaney">Claire M. Slaney</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Psychiatry, Dalhousie University, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Erin N" sort="Smith, Erin N" uniqKey="Smith E" first="Erin N" last="Smith">Erin N. Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Squassina, Alessio" sort="Squassina, Alessio" uniqKey="Squassina A" first="Alessio" last="Squassina">Alessio Squassina</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cagliari</wicri:regionArea>
<wicri:noRegion>Cagliari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stamm, Thomas" sort="Stamm, Thomas" uniqKey="Stamm T" first="Thomas" last="Stamm">Thomas Stamm</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stopkova, Pavla" sort="Stopkova, Pavla" uniqKey="Stopkova P" first="Pavla" last="Stopkova">Pavla Stopkova</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Mental Health, Klecany</wicri:regionArea>
<wicri:noRegion>Klecany</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Streit, Fabian" sort="Streit, Fabian" uniqKey="Streit F" first="Fabian" last="Streit">Fabian Streit</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Szelinger, Szabolcs" sort="Szelinger, Szabolcs" uniqKey="Szelinger S" first="Szabolcs" last="Szelinger">Szabolcs Szelinger</name>
<affiliation wicri:level="2"><nlm:affiliation>The Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tighe, Sarah K" sort="Tighe, Sarah K" uniqKey="Tighe S" first="Sarah K" last="Tighe">Sarah K. Tighe</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tortorella, Alfonso" sort="Tortorella, Alfonso" uniqKey="Tortorella A" first="Alfonso" last="Tortorella">Alfonso Tortorella</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, University of Naples SUN, Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
<affiliation wicri:level="3"><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Douglas Mental Health University Institute, McGill University, Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name>
<affiliation wicri:level="1"><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia</wicri:regionArea>
<wicri:noRegion>Catalonia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Volkert, Julia" sort="Volkert, Julia" uniqKey="Volkert J" first="Julia" last="Volkert">Julia Volkert</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H" last="Witt">Stephanie H. Witt</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name>
<affiliation wicri:level="3"><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zandi, Peter P" sort="Zandi, Peter P" uniqKey="Zandi P" first="Peter P" last="Zandi">Peter P. Zandi</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Peng" sort="Zhang, Peng" uniqKey="Zhang P" first="Peng" last="Zhang">Peng Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zollner, Sebastian" sort="Zollner, Sebastian" uniqKey="Zollner S" first="Sebastian" last="Zollner">Sebastian Zollner</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Michigan, Ann Arbor, MI</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J" last="Mcmahon">Francis J. Mcmahon</name>
<affiliation wicri:level="1"><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA, mcmahonf@mail.nih.gov.</nlm:affiliation>
<country wicri:rule="url">Israël</country>
<wicri:regionArea>Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA</wicri:regionArea>
<wicri:noRegion>USA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Human molecular genetics</title>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 × 10 (-) (9); odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P = 4.53 × 10 (-) (9); OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.</div>
</front>
</TEI>
</record>
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